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Envenomation

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skin of the target and the fang sheath, a soft tissue organ surrounding the fangs, is retracted. The fang sheath retraction initiates an increase in internal pressures. This pressure differential initiates venom flow in the venom delivery system. Larger snakes have been shown to administer larger quantities of venom during strikes when compared to smaller snakes. Snake envenomation events are usually classified as either predatory or defensive in nature.
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away until the venom induces death of the target. Snake venom has a scent that is easily recognized by the snake, allowing the snake to relocate its prey once it has run away and died. While not all snake species in every situation release their prey after envenomation, venom generally assists in prey relocation. Venomous snakes have also been shown to be aware of the relative size of prey. Juvenile
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were experimentally shown to have the ability to adapt the volume of venom they expelled based on prey size. Once experienced, the juvenile Rattlesnakes consistently expelled more venom when attacking larger mice. This ability allows the snake to inject a sufficient quantity of venom to dispatch the
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Defensive envenomation events result in much larger quantities of venom being expelled into the target. Defensive envenomation can occur with 8.5 times greater venom flow rates and 10 times greater venom mass than predatory strikes. The need to quickly neutralize a target during a defensive strikes
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Predatory strikes are quite different than defensive strikes. In predatory strikes, the snake strikes and envenomates the target, and then quickly releases the target. Releasing the target prevents retaliatory damage to the snake or its venom delivery system. Once released, the target animal runs
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can be broken into four stages; strike launch, fang erection, fang penetration, and fang withdrawal. Snakes have a venom gland connected to a duct and subsequent fangs. The fangs have hollow tubes with grooved sides that allow venom to flow within them. During snake bites, the fangs penetrate the
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that penetrate the prey's skin, whereupon muscles attached to the attacker's venom reservoir squirt venom deep within the victim's body tissue. For example, the fangs of venomous snakes are connected to a venom gland by means of a duct. Death may occur as a result of bites or stings. The rate of
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YOUNG, BRUCE A.; KARDONG, KENNETH V.; et al. (18 December 2006). "Ecological and Integrative Physiology: Mechanisms Controlling Venom Expulsion in the Western Diamondback Rattlesnake, Crotalus Atrox".
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Some venoms are applied externally, especially to sensitive tissues such as the eyes, but most venoms are administered by piercing the skin of the victim. Venom in the saliva of the
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is to be applied. Each year there are around 2 million cases of snake envenomation and up to 100,000 deaths worldwide. Various anti-venom treatments exist, typically consisting of
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prey while also conserving their venom supply for subsequent strikes. The economical use of venom is important as it is a metabolically expensive resource.
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GRAUDINS, A., M. J. LITTLE, S. S. PINEDA, P. G. HAINS, G. F. KING et al., 2012 Cloning and activity of a novel α-latrotoxin from red-back spider venom.
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In particular, snakebite envenoming is considered a neglected tropical disease resulting in >100,000 deaths and maiming >400,000 people per year.
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Gutiérrez, José María; Calvete, Juan J.; Habib, Abdulrazaq G.; Harrison, Robert A.; Williams, David J.; Warrell, David A. (2017-09-14).
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and some other reptiles enters prey through bites of grooved teeth. More commonly animals have specialized organs such as hollow teeth (
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Snakes administer venom to their target by piercing the target's skin with specialized organs known as
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envenoming is described as the likelihood of venom successfully entering a system upon bite or sting.
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HAYES, WILLIAM K.; HERBERT, SHELTON S.; REHLING, G. CURTIS; GENNARO, JOSEPH F.; et al.
278: 8: 635: 630: 603: 282: 474: 455: 377: 299: 266: 128: 547: 494: 475:"Journal of Experimental Biology: Venom Flow in Rattlesnakes: Mechanics and Metering" 413: 369: 361: 304: 244: 30: 608: 459: 486: 447: 405: 381: 351: 294: 286: 536:"Envenomations: An Overview of Clinical Toxinology for the Primary Care Physician" 233:"Envenomations: An Overview of Clinical Toxinology for the Primary Care Physician" 47: 593: 535: 232: 624: 365: 490: 551: 498: 451: 417: 373: 308: 248: 194: 113: 356: 339: 165: 78: 576: 267:"Diagnosis of snake envenomation using a simple phospholipase A2 assay" 211: 190: 182: 70: 35: 534:
WEINSTEIN, SCOTT A.; DART, RICHARD C.; et al. (15 October 2009).
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Maduwage, Kalana; O'Leary, Margaret A.; Isbister, Geoffrey K. (2014).
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WEINSTEIN, SCOTT A.; DART, RICHARD C.; et al. (15 October 2009).
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Diagnosing snake envenomation is a crucial step in determining which
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YOUNG, BRUCE A.; ZAHN, KRISTA; et al. (15 December 2001).
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is injected by the bite or sting of a venomous animal.
511: 189:. Certain snakes require certain treatments, such as 566: 429: 427: 136: 93:) employ venom for hunting and for self-defense. 622: 424: 533: 230: 132:Diagram of a snake's venom penetration system 394: 185:or antibody fragments, which neutralize the 100:A droplet of venom on the stinger of a wasp 172: 472: 355: 298: 260: 258: 160:explains these higher venom quantities. 127: 95: 434:HAYES, WILLIAM K.; et al. (1995). 623: 433: 398:Ecological and Integrative Physiology 255: 333: 331: 13: 14: 647: 562: 328: 53:Many kinds of animals, including 137:Mechanisms of snake envenomation 479:Journal of Experimental Biology 527: 505: 466: 388: 344:Nature Reviews Disease Primers 315: 224: 1: 217: 107: 7: 200: 59:northern short-tailed shrew 10: 652: 140: 16:Process of venom injection 570: 540:American Family Physician 237:American Family Physician 29: 24: 323:Biochemical Pharmacology 207:List of venomous animals 46:is the process by which 491:10.1242/jeb.204.24.4345 173:Diagnosis and treatment 452:10.1006/anbe.1995.0218 340:"Snakebite envenoming" 133: 101: 521:Biology of the Vipers 131: 99: 357:10.1038/nrdp.2017.63 283:2014NatSR...4E4827M 89:), and fish (e.g., 271:Scientific Reports 134: 102: 63:Blarina brevicauda 618: 617: 485:(24): 4345–4351. 410:10.1002/jez.a.341 291:10.1038/srep04827 41: 40: 19:Medical condition 643: 568: 567: 556: 555: 531: 525: 524: 518: 509: 503: 502: 470: 464: 463: 440:Animal Behaviour 431: 422: 421: 392: 386: 385: 359: 335: 326: 319: 313: 312: 302: 262: 253: 252: 228: 22: 21: 651: 650: 646: 645: 644: 642: 641: 640: 621: 620: 619: 614: 613: 579: 565: 560: 559: 532: 528: 516: 510: 506: 471: 467: 432: 425: 393: 389: 336: 329: 320: 316: 263: 256: 229: 225: 220: 203: 175: 145: 139: 110: 20: 17: 12: 11: 5: 649: 639: 638: 633: 616: 615: 612: 611: 596: 580: 575: 574: 572: 571:Classification 564: 563:External links 561: 558: 557: 546:(8): 793–802. 526: 504: 465: 423: 387: 327: 314: 254: 243:(8): 793–802. 222: 221: 219: 216: 215: 214: 209: 202: 199: 174: 171: 138: 135: 120:) and tubular 109: 106: 39: 38: 33: 27: 26: 18: 15: 9: 6: 4: 3: 2: 648: 637: 634: 632: 629: 628: 626: 610: 606: 605: 601: 597: 595: 591: 590: 586: 582: 581: 578: 573: 569: 553: 549: 545: 541: 537: 530: 522: 515: 508: 500: 496: 492: 488: 484: 480: 476: 469: 461: 457: 453: 449: 445: 441: 437: 430: 428: 419: 415: 411: 407: 403: 399: 391: 383: 379: 375: 371: 367: 363: 358: 353: 349: 345: 341: 334: 332: 324: 318: 310: 306: 301: 296: 292: 288: 284: 280: 276: 272: 268: 261: 259: 250: 246: 242: 238: 234: 227: 223: 213: 210: 208: 205: 204: 198: 196: 192: 188: 184: 180: 170: 167: 161: 157: 154: 150: 144: 130: 126: 123: 119: 115: 105: 98: 94: 92: 88: 84: 80: 76: 72: 68: 64: 60: 56: 51: 49: 45: 37: 34: 32: 28: 23: 598: 583: 543: 539: 529: 520: 507: 482: 478: 468: 443: 439: 404:(1): 18–27. 401: 397: 390: 350:(1): 17063. 347: 343: 325:83: 170–183. 317: 274: 270: 240: 236: 226: 195:coral snakes 176: 166:Rattlesnakes 162: 158: 146: 114:Gila monster 111: 103: 79:black widows 62: 52: 44:Envenomation 43: 42: 25:Envenomation 69:(e.g., the 57:(e.g., the 636:Toxicology 631:Physiology 625:Categories 218:References 212:Toxicology 191:pit vipers 183:antibodies 153:Snakebites 141:See also: 108:Mechanisms 91:stone fish 71:king cobra 36:Toxicology 446:: 33–40. 366:2056-676X 179:antivenom 143:Snakebite 31:Specialty 552:19835341 499:11815658 460:53160144 418:17094108 374:28905944 309:24777205 277:: 4827. 249:19835341 201:See also 122:stingers 67:reptiles 382:4916503 300:4003729 279:Bibcode 85:(e.g., 83:insects 77:(e.g., 75:spiders 55:mammals 550:  497:  458:  416:  380:  372:  364:  307:  297:  247:  594:Xxx.x 517:(PDF) 456:S2CID 378:S2CID 187:venom 149:fangs 118:fangs 87:wasps 48:venom 604:9-CM 548:PMID 495:PMID 414:PMID 402:307A 370:PMID 362:ISSN 305:PMID 245:PMID 193:and 609:xxx 600:ICD 585:ICD 487:doi 483:204 448:doi 406:doi 352:doi 295:PMC 287:doi 81:), 73:), 65:), 627:: 607:: 592:: 589:10 544:80 542:. 538:. 519:. 493:. 481:. 477:. 454:. 444:50 442:. 438:. 426:^ 412:. 400:. 376:. 368:. 360:. 346:. 342:. 330:^ 303:. 293:. 285:. 273:. 269:. 257:^ 241:80 239:. 235:. 151:. 61:, 602:- 587:- 577:D 554:. 523:. 501:. 489:: 462:. 450:: 420:. 408:: 384:. 354:: 348:3 311:. 289:: 281:: 275:4 251:.

Index

Specialty
Toxicology
venom
mammals
northern short-tailed shrew
reptiles
king cobra
spiders
black widows
insects
wasps
stone fish

Gila monster
fangs
stingers

Snakebite
fangs
Snakebites
Rattlesnakes
antivenom
antibodies
venom
pit vipers
coral snakes
List of venomous animals
Toxicology
"Envenomations: An Overview of Clinical Toxinology for the Primary Care Physician"
PMID

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