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Ensembl genome database project

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database for subsequent analysis and display. Ensembl makes these data freely accessible to the world research community. All the data and code produced by the Ensembl project is available to download, and there is also a publicly accessible database server allowing remote access. In addition, the
29: 175:, whereby a team of scientists tries to locate genes using experimental data from scientific journals and public databases. However this is a slow, painstaking task. The alternative, known as automated annotation, is to use the power of computers to do the complex 289:. These are shown as data tracks, and individual tracks can be turned on and off, allowing the user to customise the display to suit their research interests. The interface also enables the user to zoom in to a region or move along the genome in either direction. 2894: 2162:
Ruffier, Magali; Kähäri, Andreas; Komorowska, Monika; Keenan, Stephen; Laird, Matthew; Longden, Ian; Proctor, Glenn; Searle, Steve; Staines, Daniel; Taylor, Kieron; Vullo, Alessandro; Yates, Andrew; Zerbino, Daniel; Flicek, Paul (January 2017).
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database, avoiding the need to download enormous datasets. The users could even choose to retrieve data from the MySQL with direct SQL queries, but this requires an extensive knowledge of the current database schema.
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Howe, Kevin L.; Contreras-Moreira, Bruno; De Silva, Nishadi; Maslen, Gareth; Akanni, Wasiu; Allen, James; Alvarez-Jarreta, Jorge; Barba, Matthieu; Bolser, Dan M.; Cambell, Lahcen; Carbajo, Manuel (8 January 2020).
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The annotated genomes include most fully sequenced vertebrates and selected model organisms. All of them are eukaryotes, there are no prokaryotes. As of 2022, there are 271 species registered, this includes:
308:) across a range of species. The graphics are complemented by tabular displays, and in many cases data can be exported directly from the page in a variety of standard file formats such as 354:
to be written to retrieve data of interest. The same API is used internally by the web interface to display the data. It is divided in sections like the core API, the compara API (for
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data), the variation API (for accessing SNPs, SNVs, CNVs..), and the functional genomics API (to access regulatory data). The Ensembl website provides extensive information on
191:, with the initial goals of automatically annotate the human genome, integrate this annotation with available biological data and make all this knowledge publicly available. 2803: 2742: 1526: 2637: 3142: 2821: 1449: 2212:
Hubbard, T. J. P.; Aken, B. L.; Ayling, S.; Ballester, B.; Beal, K.; Bragin, E.; Brent, S.; Chen, Y.; Clapham, P.; Clarke, L.; Coates, G. (January 2009).
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Central to the Ensembl concept is the ability to automatically generate graphical views of the alignment of genes and other genomic data against a
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All data part of the Ensembl project is open access and all software is open source, being freely available to the scientific community, under a
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As of 2020, Ensembl supported over 50 000 genomes across both Ensembl and Ensembl Genomes databases, adding some new innovative features such as
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Curwen, Val; Eyras, Eduardo; Andrews, T. Daniel; Clarke, Laura; Mongin, Emmanuel; Searle, Steven M. J.; Clamp, Michele (May 2004).
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Externally produced data can also be added to the display by uploading a suitable file in one of the supported formats, such as
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In the Ensembl project, sequence data are fed into the gene annotation system (a collection of software "pipelines" written in
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license. Currently, Ensembl database website is mirrored at four different locations worldwide to improve the service.
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server which can be used to download entire MySQL databases as well some selected data sets in other formats.
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International Conference on Computational Intelligence Methods for Bioinformatics and Biostatistics
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data-mining tool. It provides a web interface for downloading datasets using complex queries.
3235: 2994: 2607: 1575: 1409: 1357: 1223: 1055: 1029: 1025: 969: 895: 871: 775: 571: 257:, a new website designed to make genome annotation data available more quickly to users, and 3532: 3287: 3260: 3218: 2978: 1619: 1259: 1243: 1199: 1135: 1063: 579: 502: 462: 355: 188: 1773: 8: 3606: 3317: 2968: 2787: 2575: 1853: 1599: 1551: 1539: 1497: 1465: 1290: 1195: 1187: 1179: 1163: 1099: 1005: 997: 993: 727: 699: 587: 534: 466: 331: 187:. The Ensembl project was launched in 1999 in response to the imminent completion of the 152: 2515: 3522: 3024: 2928: 2731: 2304: 2271: 2246: 2213: 2189: 2164: 2053: 2028: 2004: 1979: 1903: 1878: 1681: 1543: 1461: 1457: 1453: 1421: 1377: 1345: 1337: 1207: 1159: 1131: 835: 751: 639: 530: 522: 351: 305: 2702:
Microsoft Research - University of Trento Centre for Computational and Systems Biology
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Stabenau A, McVicker G, Melsopp C, Proctor G, Clamp M, Birney E (February 2004).
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Ensembl website provides computer-generated visual displays of much of the data.
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Over time the project has expanded to include additional species (including key
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Graphics are generated using a suite of custom Perl modules based on
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Other displays show data at varying levels of resolution, from whole
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and regulatory features. Since April 2009, a sister project,
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African Society for Bioinformatics and Computational Biology
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Flicek P, Aken BL, Ballester B, et al. (January 2010).
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Flicek P, Amode MR, Barrell D, et al. (November 2010).
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Sainsbury Wellcome Centre for Neural Circuits and Behaviour
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Max Planck Institute of Molecular Cell Biology and Genetics
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Scientific project at the European Bioinformatics Institute
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International Nucleotide Sequence Database Collaboration
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Ensembl: Browsing chordate genomes on EBI Train OnLine
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sequences, or present other types of display such as
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In addition to its website, Ensembl provides a REST
2026: 2514:, database of protein sequences grouping together 1977: 3185:Wellcome Trust Centre for the History of Medicine 3649: 2749:US National Center for Biotechnology Information 3246:Coalition for Epidemic Preparedness Innovations 2834:International Society for Computational Biology 365:This software can be used to access the public 153:the University of California, Santa Cruz (UCSC) 2901:ISCB Africa ASBCB Conference on Bioinformatics 2105:"The Ensembl automatic gene annotation system" 334:, the standard Perl graphics display library. 296:down to text-based representations of DNA and 3083: 2848:Institute of Genomics and Integrative Biology 2463: 337: 167:, which code for approximately 20,000–25,000 2877:European Conference on Computational Biology 2912:Research in Computational Molecular Biology 1876: 163:The human genome consists of three billion 3090: 3076: 2889:International Conference on Bioinformatics 2470: 2456: 373:Large datasets can be retrieved using the 268: 3658:Genetic engineering in the United Kingdom 2883:Intelligent Systems for Molecular Biology 2352: 2303: 2245: 2188: 2138: 2120: 2078:"Medical definition of Genome Annotation" 2052: 2003: 1954: 1902: 1877:Yates A. D.; et al. (January 2020). 3678:Science and technology in Cambridgeshire 3618:Wellcome Trust Principal Research Fellow 2076:Davis, Charles Patrick (29 March 2021). 1870: 272: 3668:Medical databases in the United Kingdom 2871:Basel Computational Biology Conference‎ 1928: 132:. Ensembl is one of several well known 3650: 3143:WTC for Gene Regulation and Expression 2020: 1971: 1767: 1092:chicken (paternal White leghorn layer) 676:Upper Galilee mountains blind mole rat 3622:Wellcome Trust Senior Research Fellow 3071: 2828:International Society for Biocuration 2726:European Molecular Biology Laboratory 2451: 2329:"The Ensembl Core Software Libraries" 2075: 1931:"The Ensembl genome database project" 1816:---- Cloud-based mirror in Singapore 3587:Institutional Strategic Support Fund 3050: 2320: 1924: 1922: 1829:List of sequenced eukaryotic genomes 2854:Japanese Society for Bioinformatics 13: 3097: 2816:European Molecular Biology network 2477: 387: 14: 3714: 2906:Pacific Symposium on Biocomputing 2810:Australia Bioinformatics Resource 2777:Swiss Institute of Bioinformatics 2760:Netherlands Bioinformatics Centre 2720:European Bioinformatics Institute 2402: 1919: 118:European Bioinformatics Institute 70:European Bioinformatics Institute 3632: 3631: 3202: 3049: 3038: 3037: 2708:Database Center for Life Science 2696:Computational Biology Department 2584:Arabidopsis Information Resource 32: 27: 22:Ensembl genome database project. 3581:Collaborative Awards in Science 3293:Malawi Liverpool Wellcome Trust 2554:Specialised genomic databases: 2369: 116:is a scientific project at the 114:Ensembl genome database project 3584:Investigator Awards in Science 3190:Wellcome Research Laboratories 3155:WTC for Molecular Parasitology 3152:WTC for Mitochondrial Research 2755:Japanese Institute of Genetics 2262: 2205: 2155: 2096: 2069: 1929:Hubbard, T. (1 January 2002). 966:Argentine black and white tegu 672:thirteen-lined ground squirrel 360:how to install and use the API 1: 3683:South Cambridgeshire District 2675:Rosalind (education platform) 2592:Zebrafish Information Network 2560:Saccharomyces Genome Database 1990:(Database issue): D800–D806. 1864: 1531:Periophthalmus magnuspinnatus 261:, a new website to access to 124:of our own species and other 3138:WTC for Cell-Matrix Research 3005:List of biological databases 2524:Protein Information Resource 2224:(Database issue): D690–697. 1834:List of biological databases 435:black-capped squirrel monkey 7: 3283:Genome Reference Consortium 3231:Cambridge Biomedical Campus 2498:European Nucleotide Archive 2039:(Database issue): D557–62. 1822: 1002:Goode's thornscrub tortoise 281:aligned to the human genome 10: 3719: 3164:WTC for Stem Cell Research 1088:chicken (maternal Broiler) 401: 338:Alternative access methods 158: 147:and browsers are found at 3629: 3571: 3480: 3445: 3391:Executive leadership team 3390: 3341: 3211: 3200: 3177: 3169:Wellcome Sanger Institute 3112: 3105: 3033: 2987: 2921: 2863: 2796: 2783:Wellcome Sanger Institute 2737:J. Craig Venter Institute 2683: 2661: 2600: 2485: 1694: 1438:horned golden-line barbel 415: 408: 95: 90: 78: 60: 55: 45: 40: 26: 3133:Science Learning Centres 2766:Philippine Genome Center 1758:Saccharomyces cerevisiae 1596:three-spined stickleback 1527:Paramormyrops kingsleyae 1124:eastern spot-billed duck 1084:chicken (Red junglefowl) 978:chinese softshell turtle 640:North American deermouse 495:golden snub-nosed monkey 3590:Science Strategic Award 3349:Eliza Manningham-Buller 3212:Projects and facilities 3120:Francis Crick Institute 3010:Molecular phylogenetics 2506:China National GeneBank 2181:10.1093/database/bax020 1844:Sequence profiling tool 1711:Drosophila melanogaster 1522:orbiculate cardinalfish 1350:blunt-snouted clingfish 1148:golden-collared manakin 1038:West African mud turtle 592:daurian ground squirrel 439:black snub-nosed monkey 269:Displaying genomic data 3572:Awards and fellowships 3323:Wellcome Genome Campus 3251:COSMIC cancer database 3148:WTC for Human Genetics 3106:Centres and institutes 2714:DNA Data Bank of Japan 2502:DNA Data Bank of Japan 2276:Nucleic Acids Research 2218:Nucleic Acids Research 1935:Nucleic Acids Research 1784:Official mirror sites 1738:Caenorhabditis elegans 1482:Makobe island chichlid 1256:white-throated sparrow 1236:spoon-billed sandpiper 982:common snapping turtle 974:central bearded dragon 792:lesser hedgehog tenrec 624:long-tailed chinchilla 620:lesser Egyptian jerboa 576:arctic ground squirrel 559:(Rodents + Lagomorphs) 282: 3703:Computational biology 3614:Wellcome Trust Centre 3611:Wellcome Image Awards 3236:Cancer Genome Project 2995:Computational biology 2510:Secondary databases: 2029:"Ensembl's 10th year" 1790:UK (Sanger Institute) 1576:Siamese fighting fish 1358:Burton's mouthbrooder 1224:rufous-capped babbler 1030:three-toed box turtle 1026:Pinta Island tortoise 970:blue-ringed sea krait 776:greater horseshoe bat 600:eurasian red squirrel 276: 136:for the retrieval of 3693:Biological databases 3288:Human Genome Project 3261:Diamond Light Source 3219:1000 Genomes Project 3159:WTC for Neuroimaging 2492:Sequence databases: 1806:US East (Amazon AWS) 1798:US West (Amazon AWS) 1620:yellowtail amberjack 1616:western mosquitofish 1540:pinecone soldierfish 1466:large yellow croaker 1260:yellow-billed amazon 1216:ring-necked pheasant 1200:northern spotted owl 1136:eurasian sparrowhawk 1064:blue-crowned manakin 1018:mainland tiger snake 503:greater bamboo lemur 356:comparative genomics 189:Human Genome Project 3607:Wellcome Book Prize 3599:Sir Henry Wellcome 3318:Wellcome Collection 2788:Whitehead Institute 2576:Rat Genome Database 2433:UCSC Genome Browser 1996:10.1093/nar/gkq1064 1947:10.1093/nar/30.1.38 1854:UCSC Genome Browser 1780: 1768:Open source/mirrors 1600:tiger tail seahorse 1552:red-bellied piranha 1498:Monterrey platyfish 1362:channel bull blenny 1196:New Caledonian crow 1188:medium ground finch 1180:little spotted kiwi 1164:helmeted guineafowl 998:saltwater crocodile 994:eastern brown snake 728:California sea lion 700:american black bear 588:damaraland mole rat 580:Brazilian guineapig 535:Ugandan red colobus 467:crab-eating macaque 398: 23: 3414:Peter Pereira Gray 3342:Board of governors 3025:Sequence alignment 2732:Flatiron Institute 2381:uswest.ensembl.org 2345:10.1101/gr.1857204 2288:10.1093/nar/gkz890 2230:10.1093/nar/gkn828 2122:10.1101/gr.1858004 2045:10.1093/nar/gkp972 1895:10.1093/nar/gkz966 1792:---- main website 1779: 1682:Ciona intestinalis 1658:Petromyzon marinus 1612:turquoise killfish 1446:indian glassy fish 1422:golden-line barbel 1338:bicolor damselfish 1291:Xenopus tropicalis 1208:oriental scops owl 1204:okarito brown kiwi 1160:great spotted kiwi 1132:eurasian eagle-owl 1100:colared flycatcher 986:common wall lizard 836:Siberian musk deer 523:pig-tailed macaque 396: 380:Last, there is an 304:of similar genes ( 283: 265:reference genome. 224:genetic variations 21: 3645: 3644: 3359:Tobias Bonhoeffer 3198: 3197: 3065: 3064: 3020:Sequence database 2534:Protein Data Bank 2528:Other databases: 2282:(D1): D689–D695. 2033:Nucleic Acids Res 1984:Nucleic Acids Res 1889:(D1): D682–D688. 1883:Nucleic Acids Res 1839:Sequence analysis 1820: 1819: 1814:Asia (Amazon AWS) 1765: 1764: 1716:Anopheles gambiae 1624:Takifugu rubripes 1568:sheepshead minnow 1458:javanese ricefish 1430:greater amberjack 1382:clown anemonefish 1286:Leisan spiny toad 1244:Swainson's thrush 1212:pink-footed goose 511:Ma's night monkey 463:Coquerel's sifaka 111: 110: 3710: 3673:Medical genetics 3663:Genome databases 3635: 3634: 3481:Other key people 3446:Former directors 3420:Chonnettia Jones 3354:Michael Ferguson 3328:Wellcome Library 3206: 3125:Gurdon Institute 3110: 3109: 3092: 3085: 3078: 3069: 3068: 3053: 3052: 3041: 3040: 3000:List of biobanks 2964:Stockholm format 2772:Scripps Research 2472: 2465: 2458: 2449: 2448: 2414: 2413: 2411:Official website 2397: 2396: 2394: 2392: 2387:on 6 August 2022 2383:. 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2160: 2156: 2109:Genome Research 2101: 2097: 2087: 2085: 2084:on 14 June 2021 2074: 2070: 2025: 2021: 1976: 1972: 1927: 1920: 1875: 1871: 1867: 1825: 1770: 1462:jewelled blenny 1454:japanese medaka 1370:chinese rmedaka 1366:channel catfish 1326:atlantic salmon 1144:golden pheasant 1120:eastern buzzard 1112:dark-eyed junco 1096:chilean tinamou 1060:bengalese finch 1056:African ostrich 990:desert tortoise 928:Tasmanian devil 724:chacoan peccary 608:ground squirrel 584:chinese hamster 572:american beaver 459:common marmoset 390: 388:Current species 340: 271: 228:Ensembl Genomes 208:model organisms 161: 134:genome browsers 130:model organisms 99: 74: 62:Research center 17: 12: 11: 5: 3716: 3706: 3705: 3700: 3698:Bioinformatics 3695: 3690: 3688:Wellcome Trust 3685: 3680: 3675: 3670: 3665: 3660: 3643: 3642: 3630: 3627: 3626: 3624: 3623: 3620: 3615: 3612: 3609: 3604: 3597: 3591: 3588: 3585: 3582: 3579: 3578:Capital Awards 3575: 3573: 3569: 3568: 3566: 3565: 3563:Henry Wellcome 3560: 3555: 3550: 3545: 3540: 3535: 3530: 3525: 3520: 3515: 3510: 3505: 3500: 3495: 3490: 3484: 3482: 3478: 3477: 3475: 3474: 3468: 3465:Michael Dexter 3462: 3456: 3453:Peter Williams 3449: 3447: 3443: 3442: 3440: 3439: 3436: 3433: 3430: 3427: 3424: 3421: 3418: 3417:Mark Henderson 3415: 3412: 3409: 3406: 3403: 3400: 3394: 3392: 3388: 3387: 3385: 3384: 3379: 3374: 3372:Bryan Grenfell 3369: 3364: 3361: 3356: 3351: 3345: 3343: 3339: 3338: 3336: 3335: 3330: 3325: 3320: 3315: 3310: 3305: 3300: 3295: 3290: 3285: 3280: 3275: 3270: 3263: 3258: 3253: 3248: 3243: 3238: 3233: 3228: 3221: 3215: 3213: 3209: 3208: 3201: 3199: 3196: 3195: 3193: 3192: 3187: 3181: 3179: 3175: 3174: 3172: 3171: 3166: 3161: 3156: 3153: 3150: 3145: 3140: 3135: 3130: 3127: 3122: 3116: 3114: 3107: 3103: 3102: 3099:Wellcome Trust 3095: 3094: 3087: 3080: 3072: 3063: 3062: 3060: 3059: 3047: 3034: 3031: 3030: 3028: 3027: 3022: 3017: 3012: 3007: 3002: 2997: 2991: 2989: 2988:Related topics 2985: 2984: 2982: 2981: 2976: 2971: 2966: 2961: 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1801: 1794: 1793: 1786: 1785: 1769: 1766: 1763: 1762: 1754: 1752: 1750: 1748: 1742: 1741: 1734: 1732: 1730: 1724: 1723: 1707: 1705: 1703: 1698: 1692: 1691: 1688:Ciona savignyi 1678: 1676: 1674: 1666: 1665: 1655: 1653: 1651: 1643: 1642: 1580:spinny chromis 1572:shortfin molly 1494:Midas chichlid 1418:gilthead bream 1410:elephant shark 1378:climbing perch 1374:chinook salmon 1307: 1305: 1303: 1295: 1294: 1283: 1281: 1279: 1271: 1270: 1172:japanese quail 1168:indian peafowl 1152:gouldian finch 1108:common kestrel 1053: 1051: 1049: 1041: 1040: 1022:painted turtle 963: 961: 959: 951: 950: 945: 943: 935: 934: 913: 911: 903: 902: 893: 891: 883: 882: 869: 867: 859: 858: 844:Siberian tiger 696:american bison 689: 687: 684:Laurasiatheria 679: 678: 636:naked mole-rat 604:golden hamster 564:Algerian mouse 561: 552: 551: 546: 538: 537: 527:sooty mangabey 431:Angola colobus 428: 421: 414: 407: 389: 386: 339: 336: 270: 267: 160: 157: 109: 108: 97: 93: 92: 88: 87: 80: 76: 75: 73: 72: 66: 64: 58: 57: 53: 52: 47: 43: 42: 38: 37: 15: 9: 6: 4: 3: 2: 3715: 3704: 3701: 3699: 3696: 3694: 3691: 3689: 3686: 3684: 3681: 3679: 3676: 3674: 3671: 3669: 3666: 3664: 3661: 3659: 3656: 3655: 3653: 3640: 3639: 3628: 3621: 3619: 3616: 3613: 3610: 3608: 3605: 3602: 3598: 3596: 3592: 3589: 3586: 3583: 3580: 3577: 3576: 3574: 3570: 3564: 3561: 3559: 3556: 3554: 3551: 3549: 3546: 3544: 3541: 3539: 3536: 3534: 3531: 3529: 3528:Richard Hynes 3526: 3524: 3521: 3519: 3516: 3514: 3513:Oliver Franks 3511: 3509: 3506: 3504: 3501: 3499: 3496: 3494: 3491: 3489: 3488:Damon Buffini 3486: 3485: 3483: 3479: 3472: 3469: 3466: 3463: 3460: 3457: 3454: 3451: 3450: 3448: 3444: 3437: 3434: 3431: 3428: 3425: 3422: 3419: 3416: 3413: 3410: 3408:Simon Chaplin 3407: 3404: 3401: 3399: 3398:Jeremy Farrar 3396: 3395: 3393: 3389: 3383: 3380: 3378: 3377:Naguib Kheraj 3375: 3373: 3370: 3368: 3367:William Burns 3365: 3362: 3360: 3357: 3355: 3352: 3350: 3347: 3346: 3344: 3340: 3334: 3331: 3329: 3326: 3324: 3321: 3319: 3316: 3314: 3311: 3309: 3306: 3304: 3301: 3299: 3296: 3294: 3291: 3289: 3286: 3284: 3281: 3279: 3276: 3274: 3271: 3269: 3268: 3264: 3262: 3259: 3257: 3254: 3252: 3249: 3247: 3244: 3242: 3239: 3237: 3234: 3232: 3229: 3227: 3226: 3222: 3220: 3217: 3216: 3214: 3210: 3205: 3191: 3188: 3186: 3183: 3182: 3180: 3176: 3170: 3167: 3165: 3162: 3160: 3157: 3154: 3151: 3149: 3146: 3144: 3141: 3139: 3136: 3134: 3131: 3128: 3126: 3123: 3121: 3118: 3117: 3115: 3111: 3108: 3104: 3100: 3093: 3088: 3086: 3081: 3079: 3074: 3073: 3070: 3058: 3057: 3048: 3046: 3045: 3036: 3035: 3032: 3026: 3023: 3021: 3018: 3016: 3013: 3011: 3008: 3006: 3003: 3001: 2998: 2996: 2993: 2992: 2990: 2986: 2980: 2977: 2975: 2972: 2970: 2967: 2965: 2962: 2960: 2957: 2955: 2954:Pileup format 2952: 2950: 2947: 2945: 2942: 2940: 2937: 2935: 2932: 2930: 2927: 2926: 2924: 2920: 2913: 2910: 2907: 2904: 2902: 2899: 2896: 2893: 2890: 2887: 2884: 2881: 2878: 2875: 2872: 2869: 2868: 2866: 2862: 2855: 2852: 2849: 2846: 2841: 2838: 2837: 2835: 2832: 2829: 2826: 2823: 2820: 2817: 2814: 2811: 2808: 2805: 2802: 2801: 2799: 2797:Organizations 2795: 2789: 2786: 2784: 2781: 2778: 2775: 2773: 2770: 2767: 2764: 2761: 2758: 2756: 2753: 2750: 2747: 2744: 2741: 2738: 2735: 2733: 2730: 2727: 2724: 2721: 2718: 2715: 2712: 2709: 2706: 2703: 2700: 2697: 2694: 2692: 2689: 2688: 2686: 2682: 2676: 2673: 2671: 2667: 2666: 2664: 2660: 2654: 2651: 2649: 2646: 2644: 2641: 2639: 2636: 2634: 2631: 2629: 2626: 2624: 2621: 2619: 2616: 2614: 2611: 2609: 2606: 2605: 2603: 2599: 2593: 2589: 2585: 2581: 2577: 2573: 2569: 2565: 2561: 2557: 2553: 2551: 2550:Gene Ontology 2547: 2543: 2539: 2535: 2531: 2527: 2525: 2521: 2517: 2513: 2509: 2507: 2503: 2499: 2495: 2491: 2490: 2488: 2484: 2480: 2473: 2468: 2466: 2461: 2459: 2454: 2453: 2450: 2444: 2441: 2439: 2436: 2434: 2431: 2429: 2426: 2424: 2421: 2419: 2416: 2412: 2407: 2406: 2386: 2382: 2378: 2372: 2364: 2360: 2355: 2350: 2346: 2342: 2338: 2334: 2330: 2323: 2315: 2311: 2306: 2301: 2297: 2293: 2289: 2285: 2281: 2277: 2273: 2265: 2257: 2253: 2248: 2243: 2239: 2235: 2231: 2227: 2223: 2219: 2215: 2208: 2200: 2196: 2191: 2186: 2182: 2178: 2175:(1): bax020. 2174: 2170: 2166: 2158: 2150: 2146: 2141: 2136: 2132: 2128: 2123: 2118: 2114: 2110: 2106: 2099: 2083: 2079: 2072: 2064: 2060: 2055: 2050: 2046: 2042: 2038: 2034: 2030: 2023: 2015: 2011: 2006: 2001: 1997: 1993: 1989: 1985: 1981: 1974: 1966: 1962: 1957: 1952: 1948: 1944: 1940: 1936: 1932: 1925: 1923: 1914: 1910: 1905: 1900: 1896: 1892: 1888: 1884: 1880: 1873: 1869: 1860: 1857: 1855: 1852: 1850: 1847: 1845: 1842: 1840: 1837: 1835: 1832: 1830: 1827: 1826: 1815: 1812: 1811: 1807: 1804: 1803: 1799: 1796: 1795: 1791: 1788: 1787: 1783: 1782: 1777: 1775: 1760: 1759: 1755: 1753: 1751: 1749: 1747: 1744: 1743: 1740: 1739: 1735: 1733: 1731: 1729: 1726: 1725: 1721: 1720:Aedes aegypti 1717: 1713: 1712: 1708: 1706: 1704: 1702: 1699: 1697: 1696:Invertebrates 1693: 1690: 1689: 1684: 1683: 1679: 1677: 1675: 1673: 1672: 1668: 1667: 1663: 1659: 1656: 1654: 1652: 1650: 1649: 1645: 1644: 1641: 1637: 1633: 1629: 1625: 1621: 1617: 1613: 1609: 1605: 1601: 1597: 1593: 1589: 1585: 1581: 1577: 1573: 1569: 1565: 1564:sailfin molly 1561: 1557: 1553: 1549: 1548:rainbow trout 1545: 1541: 1537: 1533: 1532: 1528: 1523: 1519: 1515: 1514:ocean sunfish 1511: 1510:northern pike 1507: 1503: 1499: 1495: 1491: 1490:mexican tetra 1487: 1483: 1479: 1475: 1471: 1467: 1463: 1459: 1455: 1451: 1450:indian medaka 1447: 1443: 1439: 1435: 1431: 1427: 1423: 1419: 1415: 1414:european bass 1411: 1407: 1403: 1402:eastern happy 1399: 1395: 1391: 1387: 1383: 1379: 1375: 1371: 1367: 1363: 1359: 1355: 1351: 1347: 1343: 1339: 1335: 1331: 1330:ballan wrasse 1327: 1323: 1319: 1315: 1314:asian arowana 1311: 1308: 1306: 1304: 1302: 1301: 1297: 1296: 1293: 1292: 1287: 1284: 1282: 1280: 1278: 1277: 1273: 1272: 1269: 1265: 1261: 1257: 1253: 1249: 1245: 1241: 1237: 1233: 1229: 1225: 1221: 1217: 1213: 1209: 1205: 1201: 1197: 1193: 1189: 1185: 1181: 1177: 1173: 1169: 1165: 1161: 1157: 1153: 1149: 1145: 1141: 1137: 1133: 1129: 1125: 1121: 1117: 1113: 1109: 1105: 1104:common canary 1101: 1097: 1093: 1089: 1085: 1081: 1077: 1076:burrowing owl 1073: 1069: 1065: 1061: 1057: 1054: 1052: 1050: 1048: 1047: 1043: 1042: 1039: 1035: 1031: 1027: 1023: 1019: 1015: 1014:komodo dragon 1011: 1007: 1003: 999: 995: 991: 987: 983: 979: 975: 971: 967: 964: 962: 960: 958: 957: 953: 952: 949: 946: 944: 942: 941: 937: 936: 933: 929: 925: 921: 917: 916:Common wombat 914: 912: 910: 909: 905: 904: 901: 897: 894: 892: 890: 889: 885: 884: 881: 877: 873: 870: 868: 866: 865: 861: 860: 857: 853: 849: 845: 841: 837: 833: 829: 825: 821: 817: 813: 809: 805: 801: 797: 793: 789: 785: 781: 777: 773: 769: 765: 761: 757: 753: 749: 745: 741: 737: 733: 729: 725: 721: 717: 713: 709: 708:Arabian camel 705: 704:american mink 701: 697: 693: 690: 688: 686: 685: 681: 680: 677: 673: 669: 665: 661: 657: 653: 649: 645: 641: 637: 633: 629: 625: 621: 617: 613: 609: 605: 601: 597: 593: 589: 585: 581: 577: 573: 569: 568:alpine marmot 565: 562: 560: 558: 554: 553: 550: 547: 545: 544: 540: 539: 536: 532: 528: 524: 520: 516: 512: 508: 504: 500: 496: 492: 488: 484: 480: 476: 472: 468: 464: 460: 456: 452: 448: 444: 440: 436: 432: 429: 427: 426: 422: 420: 419: 413: 412: 406: 405: 400: 394: 385: 383: 378: 376: 371: 368: 363: 361: 357: 353: 349: 345: 335: 333: 328: 326: 322: 318: 313: 311: 307: 303: 299: 295: 290: 288: 280: 275: 266: 264: 260: 256: 255:Rapid Release 251: 249: 245: 241: 237: 233: 229: 225: 221: 217: 213: 209: 204: 201: 197: 192: 190: 186: 182: 178: 174: 170: 166: 156: 154: 150: 146: 141: 140:information. 139: 135: 131: 127: 123: 119: 115: 106: 98: 94: 89: 85: 81: 77: 71: 68: 67: 65: 63: 59: 54: 51: 48: 44: 39: 35: 30: 25: 19: 3636: 3601:Postdoctoral 3558:John Sulston 3553:David Stuart 3533:Anne Johnson 3471:Mark Walport 3435:James Thomas 3382:Fiona Powrie 3265: 3223: 3054: 3042: 2949:Nexus format 2944:NeXML format 2939:FASTQ format 2934:FASTA format 2922:File formats 2684:Institutions 2537: 2389:. Retrieved 2385:the original 2380: 2371: 2336: 2332: 2322: 2279: 2275: 2264: 2221: 2217: 2207: 2172: 2168: 2157: 2112: 2108: 2098: 2086:. Retrieved 2082:the original 2071: 2036: 2032: 2022: 1987: 1983: 1973: 1941:(1): 38–41. 1938: 1934: 1886: 1882: 1872: 1771: 1756: 1736: 1719: 1718:(mosquito), 1715: 1714:(fruitfly), 1709: 1686: 1680: 1669: 1657: 1648:Cyclostomata 1646: 1623: 1525: 1506:Nile tilapia 1406:electric eel 1346:blue tilapia 1342:blind barbel 1318:atlantic cod 1310:Amazon molly 1299: 1289: 1276:Lissamphibia 1274: 1192:muscovy duck 1140:golden eagle 1044: 1010:indian cobra 954: 938: 906: 886: 862: 856:yarkand deer 756:domestic yak 716:beluga whale 682: 668:steppe mouse 660:Ryukyu mouse 652:prairie vole 616:kangaroo rat 555: 541: 507:green monkey 423: 416: 409: 402: 391: 379: 372: 364: 341: 329: 314: 291: 284: 252: 205: 193: 162: 142: 113: 112: 83: 49: 18: 3548:David Steel 3543:Peter Rigby 3518:Roger Gibbs 3503:Harold Cook 3473:(2003–2013) 3467:(1998–2008) 3461:(1991–1998) 3455:(1965–1991) 3429:Kathy Poole 3426:Nick Moakes 3225:Big Picture 2929:CRAM format 2850:(CSIR-IGIB) 2423:Pre-Ensembl 1722:(mosquito) 1664:), hagfish 1662:sea lamprey 1636:zebra mbuna 1604:tongue sole 1584:spotted gar 1394:common carp 1390:coho salmon 1354:brown trout 1268:zebra finch 1006:green anole 908:Marsupialia 840:sperm whale 772:giant panda 732:Canada lynx 664:shrew mouse 483:mouse lemur 346:and a Perl 126:vertebrates 46:Description 3652:Categories 3603:Fellowship 3595:Fellowship 3538:Roy Porter 3523:Henry Dale 3508:Kay Davies 3438:Ed Whiting 3423:Tim Livett 3411:Alyson Fox 3402:Chris Bird 3363:Alan Brown 3313:UK Biobank 3015:Sequencing 2979:GTF format 2974:GFF format 2969:VCF format 2959:SAM format 2722:(EMBL-EBI) 2648:SOAP suite 2568:VectorBase 2530:BioNumbers 2516:Swiss-Prot 1865:References 1640:zigzag eel 1560:round goby 1536:pike-perch 1386:coelacanth 1248:swan goose 1228:silver-eye 1072:budgerigar 940:Monotremes 864:Afrotheria 816:polar bear 720:blue whale 549:tree shrew 543:Scandentia 455:chimpanzee 306:homologues 298:amino acid 294:karyotypes 263:SARS-CoV-2 173:annotation 165:base pairs 3432:Jim Smith 2842:(ISCB-SC) 2812:(EMBL-AR) 2745:(MPI-CBG) 2486:Databases 2296:1362-4962 2238:1362-4962 2131:1088-9051 1774:CC BY 4.0 1671:Tunicates 1632:zebrafish 1592:tetraodon 1588:swamp eel 1544:platyfish 1502:mummichog 1156:great tit 896:Armadillo 888:Xenarthra 612:guineapig 519:orangutan 220:zebrafish 145:databases 3638:Category 3333:WormBase 3278:Farmcare 3256:DECIPHER 3044:Category 2914:(RECOMB) 2864:Meetings 2818:(EMBnet) 2668:Server: 2643:SAMtools 2638:PANGOLIN 2601:Software 2580:PHI-base 2572:WormBase 2542:InterPro 2391:5 August 2363:15123588 2314:31598706 2256:19033362 2199:28365736 2169:Database 2149:15123590 2088:7 August 2063:19906699 2014:21045057 1965:11752248 1913:31691826 1823:See also 1556:reedfish 1474:lumpfish 1426:goldfish 1300:Teleosts 1068:blue tit 956:Reptilia 948:Platypus 872:Elephant 852:wild yak 808:microbat 780:hedgehog 513:, olive 451:capuchin 447:bushbaby 425:Primates 411:Mammalia 404:Chordata 397:Species 259:COVID-19 248:protists 244:bacteria 216:fruitfly 210:such as 143:Similar 103:.ensembl 3273:Ensembl 3113:Current 3056:Commons 2891:(InCoB) 2836:(ISCB) 2824:(INSDC) 2806:(ASBCB) 2710:(DBCLS) 2704:(COSBI) 2618:Clustal 2564:FlyBase 2538:Ensembl 2512:UniProt 2494:GenBank 2305:6943047 2247:2686571 2190:5467575 2054:2808936 2005:3013672 1904:7145704 1701:Insects 1184:mallard 1080:chicken 1034:tuatara 932:wallaby 924:opossum 848:vaquita 824:red fox 812:narwhal 804:megabat 800:meerkat 788:leopard 752:dolphin 531:tarsier 499:gorilla 479:macaque 375:BioMart 352:scripts 232:metazoa 181:protein 159:History 138:genomic 122:genomes 96:Website 82:Yates, 56:Contact 50:Ensembl 41:Content 3298:MEROPS 3241:ChEMBL 3178:Former 2897:(CIBB) 2885:(ISMB) 2879:(ECCB) 2856:(JSBi) 2762:(NBIC) 2751:(NCBI) 2739:(JCVI) 2728:(EMBL) 2716:(DDBJ) 2670:ExPASy 2653:TopHat 2633:MUSCLE 2623:EMBOSS 2613:Bowtie 2588:GISAID 2548:, and 2520:TrEMBL 2361:  2354:479122 2351:  2312:  2302:  2294:  2254:  2244:  2236:  2197:  2187:  2147:  2140:479124 2137:  2129:  2061:  2051:  2012:  2002:  1963:  1953:  1911:  1901:  1859:ENCODE 1608:turbot 1442:huchen 1252:turkey 1176:kakapo 880:tenrec 768:ferret 760:donkey 692:Alpaca 656:rabbit 557:Glires 515:baboon 491:gibbon 487:gelada 443:bonobo 246:, and 236:plants 91:Access 86:(2020) 84:et al. 3267:eLife 2908:(PSB) 2830:(ISB) 2779:(SIB) 2768:(PGC) 2698:(CBD) 2662:Other 2628:HMMER 2608:BLAST 1956:99161 1746:Yeast 1728:Worms 1434:guppy 1046:Birds 920:koala 900:sloth 876:hyrax 832:shrew 828:sheep 784:horse 744:dingo 632:mouse 475:human 471:drill 367:MySQL 323:, or 310:FASTA 302:trees 277:Gene 240:fungi 212:mouse 200:MySQL 169:genes 3308:Rfam 3303:Pfam 2590:and 2556:BOLD 2546:KEGG 2522:and 2504:and 2438:NCBI 2418:Vega 2393:2022 2359:PMID 2310:PMID 2292:ISSN 2252:PMID 2234:ISSN 2195:PMID 2173:2017 2145:PMID 2127:ISSN 2090:2022 2059:PMID 2010:PMID 1961:PMID 1909:PMID 1628:fugu 1264:zebu 1220:ruff 1116:duck 796:lion 764:goat 648:pika 596:degu 279:SGCB 218:and 196:Perl 151:and 149:NCBI 128:and 105:.org 2349:PMC 2341:doi 2300:PMC 2284:doi 2242:PMC 2226:doi 2185:PMC 2177:doi 2135:PMC 2117:doi 2049:PMC 2041:doi 2000:PMC 1992:doi 1951:PMC 1943:doi 1899:PMC 1891:doi 1630:), 1128:emu 820:pig 814:, 748:dog 740:cow 736:cat 714:, 644:rat 382:FTP 348:API 344:API 325:PSL 321:BED 317:BAM 185:DNA 183:to 179:of 101:www 3654:: 2873:() 2586:, 2582:, 2578:, 2574:, 2570:, 2566:, 2562:, 2558:, 2544:, 2540:, 2536:, 2532:, 2518:, 2500:, 2496:, 2379:. 2357:. 2347:. 2337:14 2335:. 2331:. 2308:. 2298:. 2290:. 2280:48 2278:. 2274:. 2250:. 2240:. 2232:. 2222:37 2220:. 2216:. 2193:. 2183:. 2171:. 2167:. 2143:. 2133:. 2125:. 2113:14 2111:. 2107:. 2057:. 2047:. 2037:38 2035:. 2031:. 2008:. 1998:. 1988:39 1986:. 1982:. 1959:. 1949:. 1939:30 1937:. 1933:. 1921:^ 1907:. 1897:. 1887:48 1885:. 1881:. 1685:, 1638:, 1634:, 1622:, 1618:, 1614:, 1610:, 1606:, 1602:, 1598:, 1594:, 1590:, 1586:, 1582:, 1578:, 1574:, 1570:, 1566:, 1562:, 1558:, 1554:, 1550:, 1546:, 1542:, 1538:, 1534:, 1529:, 1524:, 1520:, 1516:, 1512:, 1508:, 1504:, 1500:, 1496:, 1492:, 1488:, 1484:, 1480:, 1476:, 1472:, 1468:, 1464:, 1460:, 1456:, 1452:, 1448:, 1444:, 1440:, 1436:, 1432:, 1428:, 1424:, 1420:, 1416:, 1412:, 1408:, 1404:, 1400:, 1396:, 1392:, 1388:, 1384:, 1380:, 1376:, 1372:, 1368:, 1364:, 1360:, 1356:, 1352:, 1348:, 1344:, 1340:, 1336:, 1332:, 1328:, 1324:, 1320:, 1316:, 1312:, 1288:, 1266:, 1262:, 1258:, 1254:, 1250:, 1246:, 1242:, 1238:, 1234:, 1230:, 1226:, 1222:, 1218:, 1214:, 1210:, 1206:, 1202:, 1198:, 1194:, 1190:, 1186:, 1182:, 1178:, 1174:, 1170:, 1166:, 1162:, 1158:, 1154:, 1150:, 1146:, 1142:, 1138:, 1134:, 1130:, 1126:, 1122:, 1118:, 1114:, 1110:, 1106:, 1102:, 1098:, 1094:, 1090:, 1086:, 1082:, 1078:, 1074:, 1070:, 1066:, 1062:, 1058:, 1036:, 1032:, 1028:, 1024:, 1020:, 1016:, 1012:, 1008:, 1004:, 1000:, 996:, 992:, 988:, 984:, 980:, 976:, 972:, 968:, 930:, 926:, 922:, 918:, 898:, 878:, 874:, 854:, 850:, 846:, 842:, 838:, 834:, 830:, 826:, 822:, 818:, 810:, 806:, 802:, 798:, 794:, 790:, 786:, 782:, 778:, 774:, 770:, 766:, 762:, 758:, 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Index



Research center
European Bioinformatics Institute
www.ensembl.org
European Bioinformatics Institute
genomes
vertebrates
model organisms
genome browsers
genomic
databases
NCBI
the University of California, Santa Cruz (UCSC)
base pairs
genes
annotation
pattern-matching
protein
DNA
Human Genome Project
Perl
MySQL
model organisms
mouse
fruitfly
zebrafish
genetic variations
Ensembl Genomes
metazoa

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