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where the reactant is a nucleophile rather than an electrophile. The four possible electrophilic aliphatic substitution reaction mechanisms are
213:
105:
59:
72:, usually hydrogen, is replaced by an electrophile. The most important reactions of this type that take place are
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and a positively charged organic residue. The carbanion then quickly recombines with the electrophile. The S
38:, which is typically, but not always, aromatic. Aromatic substitution reactions are characteristic of
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compounds, an electrophile displaces a functional group. This reaction is similar to
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lectrophilic), which are also similar to the nucleophile counterparts
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compounds and are common ways of introducing functional groups into
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in which the old bond and the newly formed bond are both present.
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compounds can undergo electrophilic substitution as well.
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95:
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1 course of action the substrate first ionizes into a
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Electrophilic aliphatic substitution reactions are:
92:. It further consists of alkylation and acylation.
236:
237:
225:
214:Carbonyl alpha-substitution reactions
96:Electrophilic aliphatic substitution
20:Electrophilic substitution reactions
106:nucleophilic aliphatic substitution
60:Electrophilic aromatic substitution
54:Electrophilic aromatic substitution
13:
176:2 reaction mechanism has a single
14:
256:
100:In electrophilic substitution in
64:In electrophilic substitution in
1:
219:
203:Aliphatic diazonium coupling
7:
10:
261:
228:Advanced Organic Chemistry
68:, an atom appended to the
57:
210:insertion into C-H bonds
90:Friedel-Crafts reactions
245:Substitution reactions
230:(5th ed.). Wiley.
226:March, Jerry (1985).
198:Keto-enol tautomerism
78:aromatic halogenation
82:aromatic sulfonation
193:Ketone halogenation
74:aromatic nitration
66:aromatic compounds
24:chemical reactions
16:Chemical reaction
252:
231:
178:transition state
32:functional group
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88:and alkylating
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58:Main article:
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70:aromatic ring
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144:ubstitution
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46:rings. Some
30:displaces a
28:electrophile
26:in which an
19:
18:
188:Nitrosation
132:(back) and
220:References
164:. In the S
170:carbanion
124:(front),
102:aliphatic
86:acylation
48:aliphatic
239:Category
40:aromatic
36:compound
208:Carbene
44:benzene
34:in a
156:and
84:and
22:are
241::
116:,
80:,
76:,
174:E
166:E
162:2
160:N
158:S
154:1
152:N
150:S
146:E
142:S
140:(
138:i
136:E
134:S
130:2
128:E
126:S
122:2
120:E
118:S
114:1
112:E
110:S
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