345:
in 1998. The two genes were the first two components of the circadian clock or central oscillator mechanism in plants to be identified. Among many other studies of the regulation and function of CCA1, Tobin has determined that one method of clock regulation involves the phosphorylation of CCA1 by the
248:
As a student with
Winslow Briggs, Tobin had been introduced to the effects of phytochrome on flowering and to the work of Karl Hamner on circadian rhythms and flowering. Circadian rhythms in plants help them to coordinate with external light/dark cycles. Anticipating dawn, dusk, and seasonal day
311:
were low in darkness but could be rapidly and reversibly restored by light exposure. Tobin's group also demonstrated phytochrome regulation of LHCB proteins (also known as cab genes) in
Arabidopsis. By growing duckweed heterotrophically in the dark, and exposing it briefly to red and
1417:
Krahmer, Johanna; Hindle, Matthew; Perby, Laura K.; Mogensen, Helle K.; Nielsen, Tom H.; Halliday, Karen J.; Ooijen, Gerben van; Bihan, Thierry Le; Millar, Andrew J. (1 January 2022).
323:
In a series of experiments beginning in 1993, Tobin's lab described DNA-binding activity with an affinity for LHCB in plant cells. Using a DNA fragment, they screened the
Arabidopsis
765:
Thornber, J. Philip (2000). "Thirty Years of Fun with
Antenna Pigment-Proteins and Photochemical Reaction Centers: A Tribute to the People Who Have Influenced My Career".
237:, where she did postdoctoral work with Attila Klein, on the influence of light on the development of plants. In 1975 she was hired in the Biology Department at
1512:
217:, worked in his laboratory, and transferred to Harvard when Briggs took a professorship there. In 1968 she married Allan J. Tobin. They spent a year at the
1057:"The Functional Interplay between Protein Kinase CK2 and CCA1 Transcriptional Activity Is Essential for Clock Temperature Compensation in Arabidopsis"
249:
length allows plants to more effectively regulate both daily and seasonal activities, including the movement of leaves and petals, the opening of
221:
in Israel, where Elaine Tobin worked with plant geneticist Ezra Galun. After returning to North
America, she completed her Ph.D. in Biology at
1497:
580:"Constitutive Expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) Gene Disrupts Circadian Rhythms and Suppresses Its Own Expression"
1522:
494:"Expression of Light-Harvesting Chlorophyll a/b -Protein Genes Is Phytochrome-Regulated in Etiolated Arabidopsis thaliana Seedlings"
806:
American men & women of science: a biographical directory of today's leaders in physical, biological, and related sciences
1394:
1252:
813:
782:
238:
120:
100:
289:
124:
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in plants, in particular circadian oscillator proteins and the ways in which feedback loops are regulated through
1502:
242:
218:
1277:"Circadian Clock Associated1 Transcript Stability and the Entrainment of the Circadian Clock in Arabidopsis"
328:
146:
537:"A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene"
288:
photoreceptors, genes, and circadian rhythms. Tobin was able to isolate poly(A) RNA from duckweed, expose
142:. Tobin identified one of the first two components of the circadian clock in plants, the dawn expressed
187:'s presidential campaign. While in high school, she also participated in civil rights marches and heard
1419:"The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana"
1517:
213:
She was accepted into the
Biology Department at Stanford. She took classes in plant physiology with
1418:
463:
Tobin, E M; Silverthorne, J (1 June 1985). "Light
Regulation of Gene Expression in Higher Plants".
245:(NIH). She was able to obtain laboratory space previously used by retiring professor Karl Hamner.
241:(UCLA). Support was sparse, but she was able to get funding for basic research on plants from the
304:
1132:
994:
1492:
1167:"CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis"
623:"CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis"
327:, and cloned a protein with relevant binding activity, which they named CCA1. They showed that
203:
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188:
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316:
light, Tobin demonstrated the effects of phytochromes on plant growth and transcription in
276:
168:
155:
and that one type of regulation involves the phosphorylation of CCA1 by the protein kinase
151:
143:
116:
49:
724:
307:
of specific genes. Light-harvesting chlorophyll a/b-binding (LHCB) protein sequences from
8:
832:
234:
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638:
476:
419:
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1360:
1325:
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1083:
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967:
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609:
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493:
324:
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to study light regulation of gene expression in plants, examining interactions between
222:
184:
64:
1209:
1166:
711:
Tobin, Elaine (20 May 2022). "Adventures in Life and
Science, from Light to Rhythms".
665:
622:
596:
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561:
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403:
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601:
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480:
451:
433:
404:"Demonstration of transcriptional regulation of specific genes by phytochrome action"
390:
300:
179:. Munsey's interests included science, mathematics and basketball. She attended the
1034:
857:
613:
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1430:
1355:
1337:
1296:
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Yakir, Esther; Hilman, Dror; Hassidim, Miriam; Green, Rachel M. (5 November 2007).
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191:
speak in
Louisville. She graduated from Seneca High School in Louisville in 1962.
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336:
195:
156:
139:
135:
74:
60:
1434:
149:. Her lab also showed that CCA1 was necessary for phytochrome response in
1171:
Proceedings of the
National Academy of Sciences of the United States of America
774:
627:
Proceedings of the National Academy of Sciences of the United States of America
535:
Wang, Z Y; Kenigsbuch, D; Sun, L; Harel, E; Ong, M S; Tobin, E M (April 1997).
341:
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in 1966, majoring in chemistry. After graduation, she spent a summer as an
1292:
605:
570:
509:
492:
Karlin-Neumann, George A.; Sun, Lin; Tobin, Elaine M. (1 December 1988).
285:
270:
131:
552:
335:. Reports on the activity of CCA1 and a closely related gene (LHY) from
376:
119:) is a professor of molecular, cell, and developmental biology at the
902:
303:
and Tobin demonstrated that photoreceptors in plants could affect the
258:
176:
887:"Molecular mechanisms at the core of the plant circadian oscillator"
313:
250:
1165:
Daniel, Xavier; Sugano, Shoji; Tobin, Elaine M. (2 March 2004).
621:
Daniel, Xavier; Sugano, Shoji; Tobin, Elaine M. (2 March 2004).
172:
1326:"My Path from Chemistry to Phytochrome and Circadian Rhythms"
1245:
Pigment of the Imagination: A History of Phytochrome Research
293:
1416:
993:
Salomé, Patrice A.; McClung, C. Robertson (October 2004).
1274:
123:(UCLA). Tobin is recognized as a Pioneer Member of the
534:
491:
402:
Silverthorne, Jane; Tobin, Elaine M. (February 1984).
808:(24th ed.). Detroit, Mich.: Thomson Gale. 2007.
171:
on December 23, 1944. Her family had immigrated from
769:. Vol. 3. World Scientific. pp. 325–346.
1386:Plant Growth and Development: A Molecular Approach
361:"Isolation and Translation of Plant Messenger RNA"
359:Tobin, Elaine M.; Klein, Attila O. (1 July 1975).
331:(CCA1) was necessary for phytochrome response in
1164:
620:
462:
401:
1479:
1055:Portolés, Sergi; Más, Paloma (4 November 2010).
885:Nohales, Maria A; Kay, Steve A (December 2016).
408:Proceedings of the National Academy of Sciences
349:Elaine M. Tobin retired from teaching in 2014.
225:in 1972. She later married J. Philip Thornber.
1513:University of California, Los Angeles faculty
992:
578:Wang, Zhi-Yong; Tobin, Elaine M (June 1998).
833:"Elaine Tobin – Molecular Biology Institute"
706:
704:
702:
700:
698:
696:
694:
692:
194:She earned her Bachelor of Arts degree from
1133:"A Winding Road to a Happy Academic Career"
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162:
884:
760:
758:
358:
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1341:
1300:
1208:
1190:
1082:
1072:
966:
956:
934:
932:
930:
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891:Nature Structural & Molecular Biology
880:
878:
689:
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577:
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445:
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764:
292:to x-ray film, and show that while some
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296:decreased in light, others increased.
202:, working as a community organizer in
1383:Fosket, Donald E. (2 December 2012).
1323:
1268:
1130:
983:
837:University of California, Los Angeles
725:10.1146/annurev-arplant-090921-091346
710:
239:University of California, Los Angeles
121:University of California, Los Angeles
101:University of California, Los Angeles
1498:Scientists from Louisville, Kentucky
1317:
1238:
1225:
862:American Society of Plant Biologists
800:
798:
796:
794:
352:
125:American Society of Plant Biologists
1423:Molecular & Cellular Proteomics
850:
822:
477:10.1146/annurev.pp.36.060185.003033
181:1960 Democratic National Convention
13:
1239:Sage, Linda C. (2 December 2012).
85:Allan J. Tobin, J. Philip Thornber
14:
1534:
791:
465:Annual Review of Plant Physiology
134:photoreceptors interact with the
1523:21st-century American biologists
995:"The Arabidopsis thaliana Clock"
941:"The Plant Circadian Oscillator"
1099:
1247:. Elsevier. pp. 480–515.
713:Annual Review of Plant Biology
299:In 1984, postdoctoral student
1:
999:Journal of Biological Rhythms
939:McClung, CR (12 March 2019).
682:
597:10.1016/s0092-8674(00)81464-6
243:National Institutes of Health
219:Weizmann Institute of Science
1074:10.1371/journal.pgen.1001201
767:Discoveries in Plant Biology
329:Circadian Clock Associated 1
7:
1435:10.1016/j.mcpro.2021.100172
339:were submitted together to
183:as a volunteer working for
10:
1539:
1330:Frontiers in Plant Science
775:10.1142/9789812813503_0017
167:Elaine Munsey was born in
1508:Harvard University alumni
1324:Tobin, Elaine M. (2016).
228:
115:(born December 23, 1944,
106:
96:
89:
81:
70:
56:
28:
21:
1011:10.1177/0748730404268112
163:Early life and education
16:American plant biologist
1343:10.3389/fpls.2016.00261
1192:10.1073/pnas.0400163101
648:10.1073/pnas.0400163101
1503:Oberlin College alumni
1131:Tobin, Elaine (2008).
958:10.3390/biology8010014
858:"ASPB Pioneer Members"
429:10.1073/pnas.81.4.1112
263:development of flowers
233:In 1973 Tobin went to
204:Wolfe County, Kentucky
189:Martin Luther King Jr.
1293:10.1104/pp.107.103812
1241:"32. Gene regulation"
274:(duckweed) and later
200:Appalachian Volunteer
510:10.1104/pp.88.4.1323
346:protein kinase CK2.
333:Arabidopsis thaliana
277:Arabidopsis thaliana
169:Louisville, Kentucky
152:Arabidopsis thaliana
144:transcription factor
117:Louisville, Kentucky
50:Louisville, Kentucky
1183:2004PNAS..101.3292D
639:2004PNAS..101.3292D
553:10.1105/tpc.9.4.491
420:1984PNAS...81.1112S
282:model plant systems
235:Brandeis University
210:'s War on Poverty.
113:Elaine Munsey Tobin
377:10.1104/pp.56.1.88
325:expression library
268:Tobin first used
223:Harvard University
185:Adlai Stevenson II
130:Tobin studies how
65:Harvard University
1396:978-0-12-407792-8
1254:978-0-323-13854-3
903:10.1038/nsmb.3327
897:(12): 1061–1069.
815:978-1-4144-3399-8
784:978-981-02-3882-7
353:Selected research
301:Jane Silverthorne
110:
109:
91:Scientific career
43:December 23, 1944
1530:
1518:Women biologists
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1471:
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1405:
1403:
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1281:Plant Physiology
1272:
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1263:
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1236:
1223:
1222:
1212:
1194:
1177:(9): 3292–3297.
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1137:
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1121:
1119:
1117:
1103:
1097:
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1076:
1067:(11): e1001201.
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752:
708:
678:
668:
650:
633:(9): 3292–3297.
617:
599:
590:(7): 1207–1217.
574:
564:
531:
521:
504:(4): 1323–1331.
498:Plant Physiology
488:
459:
449:
431:
414:(4): 1112–1116.
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365:Plant Physiology
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709:
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355:
337:George Coupland
231:
196:Oberlin College
165:
140:gene expression
136:circadian clock
75:Circadian clock
61:Oberlin College
52:
47:
44:
38:
36:
35:
34:
24:
23:Elaine M. Tobin
17:
12:
11:
5:
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1316:
1287:(3): 925–932.
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1123:
1111:Seneca Forever
1107:"Hall of Fame"
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1005:(5): 425–435.
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547:(4): 491–507.
541:The Plant Cell
532:
489:
471:(1): 569–593.
460:
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255:photosynthesis
230:
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215:Winslow Briggs
208:Lyndon Johnson
164:
161:
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71:Known for
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1493:Living people
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1429:(1): 100172.
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1061:PLOS Genetics
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305:transcription
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45:(age 79)
33:Elaine Munsey
31:
27:
20:
1464:. Retrieved
1426:
1422:
1412:
1400:. Retrieved
1389:. Elsevier.
1385:
1378:
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1258:. Retrieved
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1114:. Retrieved
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1038:. Retrieved
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371:(1): 88–92.
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129:
112:
111:
97:Institutions
90:
1488:1944 births
1146:(6): 11, 14
719:(1): 1–16.
309:Lemna gibba
286:phytochrome
280:(cress) as
271:Lemna gibba
259:stem growth
132:phytochrome
1482:Categories
683:References
261:, and the
82:Partner(s)
39:1944-12-23
1443:1535-9476
1352:1664-462X
1201:0027-8424
1140:ASPB News
1019:0748-7304
951:(1): 14.
749:246650996
733:1543-5008
657:0027-8424
485:0066-4294
438:0027-8424
290:slab gels
177:Lithuania
77:in plants
57:Education
1461:34740825
1370:27014288
1311:17873091
1219:14978263
1093:21079791
1035:19023414
1027:15534322
977:30870980
921:27922614
741:35130444
675:14978263
614:18992734
528:16666462
456:16593420
395:16659264
127:(ASPB).
1452:8733343
1361:4791383
1336:: 261.
1302:2048808
1179:Bibcode
1084:2973838
968:6466001
945:Biology
912:7750160
635:Bibcode
606:9657153
571:9144958
519:1055760
416:Bibcode
320:genes.
314:far-red
251:stomata
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