728:
705:
1200:(brand name Cabenuva) for the treatment of HIV-1 infections in adults to replace a current antiretroviral regimen in those who are virologically suppressed on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either cabotegravir or rilpivirine. This is the first FDA-approved injectable, complete regimen for HIV-infected adults that is administered once a month. The label for rilpivirine tablets was revised to reflect the oral lead-in recommendations for use with
1116:
49:
40:
3185:
3173:
1908:
1863:
1076:
after about four to five hours. Taking the drug without food lowers its plasma levels by 40% as compared to taking it with food, which is considered to be clinically relevant. Therefore, patients are advised to take the medication together with a meal. After injection into the muscle, the substance
1111:
Elimination has only been studied for oral administration: Most of the drug is excreted via the faeces (85%), partly in unchanged form (25%), partly in form of its metabolites (60%). A minor amount is excreted via the urine (6%), almost exclusively as metabolites.
1763:
Molina JM, Cahn P, Grinsztejn B, Lazzarin A, Mills A, Saag M, et al. (July 2011). "Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial".
1035:. The most common side effects of the tablets are also depressive disorders (4.1%), headache (3.5%), insomnia (3.5%) and rashes (2.3%). All of these side effects occurred under combination therapies of rilpivirine with one or more other drugs against HIV.
1022:
The most common side effects of the injectable formulation are reactions at the injection site (in up to 84% of patients) such as pain and swelling, as well as headache (up to 12%) and fever or feeling hot (in 10%). Less common (under 10%) are
1189:, sold under the brand name Juluca, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It was approved for use in the United States in November 2017 and for use in the European Union in May 2018.
2570:
2544:
2462:
1258:
injection. It was approved for medical use in the
European Union in December 2020. The two medicines are the first antiretrovirals that come in a long-acting injectable formulation.
282:
999:. Such drugs can accelerate the breaking down of rilpivirine, substantially decreasing its plasma concentrations and potentially resulting in loss of effectiveness and possible
1168:, and was approved for use in the European Union with the brand name Eviplera in November 2011. This combination has been shown to have higher rates of virologic failure than
2564:
2754:
2759:
1956:"A Clinical Trial in Treatment naïve HIV-Subjects Patients Comparing TMC278 to Efavirenz in Combination With 2 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors"
1250:(EMA) adopted a positive opinion, recommending the granting of a marketing authorization for rilpivirine under the trade name Rekambys, intended for the treatment of
844:
as HCl: InChI=1S/C22H18N6.ClH/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19;/h3-9,11-13H,1-2H3,(H2,25,26,27,28);1H/b4-3+;
1840:
3205:
2705:
2177:
3144:
202:
791:
2341:
1885:
860:
2015:
130:
3220:
2711:
2769:
2689:
1536:
944:
2774:
1243:
901:
833:
InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
2064:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
1556:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
2722:
2123:
1492:"48-Week Primary Analysis of Trial TMC278-C204: TMC278 Demonstrates Potent and Sustained Efficacy in ART-naïve Patients. Oral abstract 144LB"
79:
2744:
2728:
805:
1014:
because the increased gastric pH causes decreased rilpivirine absorption from the gut, with similar consequences as with CYP3A4 inducers.
3097:
3092:
939:
for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/ml) with their current
1389:
2739:
1598:
1577:
2749:
1704:
1634:
1491:
1055:
1657:"Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison"
3016:
2660:
1149:
1007:
and thus reduce blood plasma concentrations of cabotegravir, further compromising the effectiveness of this combination therapy.
1926:"A Clinical Trial in Treatment naïve HIV-1 Patients Comparing TMC278 to Efavirenz in Combination With Tenofovir + Emtricitabine"
1301:
3115:
3006:
2764:
2101:
1165:
1041:
of the heart rhythm has been observed at very high doses, but is not clinically relevant at standard doses of the drug.
2779:
867:
147:
1722:
2335:
2116:
1169:
825:
3132:
2789:
2673:
2799:
2784:
2447:
2435:
1985:
1807:
390:
267:
111:
2679:
1963:
1933:
2109:
2090:
2023:
2019:
1991:
1891:
1846:
1813:
1708:
1251:
1193:
1161:
723:
524:
2044:
1414:
Stellbrink HJ (October 2007). "Antiviral drugs in the treatment of AIDS: what is in the pipeline ?".
625:
2884:
684:
617:
932:
of 100,000 copies/mL or less at therapy initiation. It has to be combined with other drugs against HIV.
3163:
1441:
Goebel F, Yakovlev A, Pozniak AL, Vinogradova E, Boogaerts G, Hoetelmans R, et al. (August 2006).
1239:
in April 2008, and was approved for use in the United States in May 2011 under the brand name
Edurant.
2049:
1641:
1605:
1584:
1541:
1365:
1331:
1247:
1236:
125:
1443:"Short-term antiviral activity of TMC278--a novel NNRTI--in treatment-naive HIV-1-infected subjects"
700:
2956:
2866:
2847:
2734:
2695:
1197:
1186:
940:
967:). Before using the injection, the tablets are given for about four weeks to assess tolerability.
645:
3120:
2716:
960:
184:
61:
17:
943:, and when the virus has not developed resistance to certain class of anti-HIV medicines called
2794:
905:
666:
335:
2902:
597:
589:
2991:
2804:
2684:
2554:
2153:
1393:
1360:
1176:
1011:
913:
513:
505:
1326:
424:
416:
3215:
2874:
2700:
2549:
2307:
2078:
1157:
1105:
909:
541:
533:
357:
2131:
1495:
8:
2809:
2668:
2540:
2458:
2257:
2136:
1841:"FDA Approves First Extended-Release, Injectable Drug Regimen for Adults Living with HIV"
1024:
407:
191:
1459:
1442:
727:
704:
1789:
1681:
1656:
1472:
158:
1777:
3210:
2951:
2614:
1781:
1705:"Approval of Complera: emtricitabine/rilpivirine/tenofovir DF fixed dose combination"
1686:
1464:
1423:
996:
656:
457:
308:
295:
103:
1476:
1080:
Independently of the mode of application, rilpivirine is almost completely bound to
449:
2976:
1793:
1773:
1676:
1668:
1519:
1454:
1217:
740:
327:
250:
239:
228:
215:
89:
3150:
1955:
1925:
1537:"First long-acting injectable antiretroviral therapy for HIV recommended approval"
3177:
3052:
3011:
2171:
1132:
1115:
1038:
1000:
345:
1275:
1108:
is approximately 45 hours for the tablets and 13 to 28 weeks for the injection.
3189:
3126:
2132:
1081:
976:
1752:(in German). Vienna: Österreichischer Apothekerverlag. Eviplera Filmtabletten.
1494:. 14th Conference on Retroviruses and Opportunistic Infections. Archived from
3199:
2892:
2642:
2477:
2363:
1912:
1867:
1224:
1153:
984:
716:
485:
195:
31:
2946:
2936:
2517:
2507:
2325:
2282:
2277:
2272:
2234:
2214:
2144:
1785:
1690:
1468:
1427:
1255:
1201:
1073:
936:
636:
245:
234:
223:
210:
3072:
3047:
2986:
2971:
2966:
2597:
2512:
2492:
2287:
2267:
2246:
2193:
2161:
1808:"Odefsey (emtricitabine, rilpivirine, and tenofovir alafenamide) Tablets"
1672:
1101:
97:
1172:
in people with baseline HIV viral loads greater than 100,000 copies/mm.
477:
3077:
3057:
3042:
3037:
3001:
2996:
2910:
2855:
2825:
2637:
2625:
2620:
2592:
2532:
2522:
2497:
2482:
2472:
2421:
2416:
2404:
2388:
2378:
2358:
2320:
2230:
2218:
2210:
1213:
1179:(TAF) was approved for use in the US in March 2016 with the brand name
1093:
1061:
992:
929:
928:
In the US, rilpivirine is approved for treatment-naive patients with a
889:
767:
496:
48:
3087:
3067:
3062:
3032:
2961:
2941:
2830:
2587:
2502:
2487:
2410:
2383:
2373:
2368:
2315:
2292:
2205:
1175:
A fixed-dose medication combining rilpivirine with emtricitabine and
1120:
1097:
988:
917:
435:
372:
83:
3082:
2467:
1276:"Edurant 25 mg tablets - Summary of Product Characteristics (SmPC)"
1028:
935:
In the
European Union, rilpivirine is approved in combination with
897:
569:
561:
468:
142:
790:
672:
2981:
2527:
2297:
1911:
This article incorporates text from this source, which is in the
1866:
This article incorporates text from this source, which is in the
1726:
1180:
1085:
893:
1440:
129:
2931:
2926:
1216:, a second-generation NNRTI approved in 2008, rilpivirine is a
1136:
1128:
1124:
1089:
1072:
When taken by mouth, rilpivirine reaches highest levels in the
1032:
1004:
980:
608:
350:
398:
4-{-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
39:
2241:
781:
580:
3184:
1762:
689:
2755:
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide
2200:
2188:
1986:"Drug Approval Package: Edurant (rilpivirine) NDA #202022#"
552:
2760:
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil
1056:
Reverse-transcriptase inhibitor § Mechanism of action
947:(NNRTIs) and integrase strand transfer inhibitors (INIs).
2225:
2140:
2706:
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide
1880:
1878:
1876:
1302:"Edurant- rilpivirine hydrochloride tablet, film coated"
1077:
reaches highest plasma levels after three to four days.
1489:
3161:
1873:
970:
975:
The drug is contraindicated for use with drugs that
1490:Pozniak A, Morales-Ramirez J, Mohap L, et al.
1886:"Cabenuva and Vocabria approved for HIV infection"
963:to be given once every month or every two months (
1227:, while the injection contains free rilpivirine.
1119:One of several metabolism pathways involving the
3197:
2712:Dolutegravir/emtricitabine/tenofovir alafenamide
1572:
1570:
1568:
1566:
1564:
1562:
1104:, and glucuronides of oxidized metabolites. The
456:
448:
3206:Non-nucleoside reverse transcriptase inhibitors
2770:Emtricitabine/rilpivirine/tenofovir alafenamide
2690:Bictegravir/emtricitabine/tenofovir alafenamide
1654:
1629:
1627:
1625:
1623:
1621:
1619:
1617:
1615:
1355:
1353:
1351:
1088:. It is metabolised mainly by the liver enzyme
1010:It is also contraindicated in combination with
945:non-nucleoside reverse transcriptase inhibitors
813:Cc1cc(cc(c1Nc2ccnc(n2)Nc3ccc(cc3)C#N)C)/C=C/C#N
423:
415:
2775:Emtricitabine/rilpivirine/tenofovir disoproxil
2261:(Integrase strand transfer inhibitors (INSTI))
1244:Committee for Medicinal Products for Human Use
902:non-nucleoside reverse transcriptase inhibitor
2723:Dolutegravir/lamivudine/tenofovir alafenamide
2117:
1655:Lade JM, Avery LB, Bumpus NN (October 2013).
1559:
1003:. Some of these drugs also induce the enzyme
955:The drug is available as tablets (brand name
2745:Efavirenz/emtricitabine/tenofovir disoproxil
2729:Dolutegravir/lamivudine/tenofovir disoproxil
1612:
1348:
644:
146:
1578:"Rekambys: EPAR – public assessment report"
1513:
1511:
1509:
1507:
1505:
1407:
2740:Doravirine/lamivudine/tenofovir disoproxil
2124:
2110:
1635:"Edurant: EPAR – public assessment report"
1413:
1164:(FDA) in August 2011 under the brand name
1143:
726:
703:
512:
504:
2750:Efavirenz/lamivudine/tenofovir disoproxil
1835:
1833:
1747:
1680:
1531:
1529:
1458:
1064:reverse transcriptase inhibitor (NNRTI).
540:
532:
3221:Drugs developed by Johnson & Johnson
3017:Zinc finger protein transcription factor
1502:
1114:
699:
484:
476:
102:
14:
3198:
1830:
1599:"Vocabria: EPAR – Product information"
1526:
1254:(HIV-1) infection in combination with
1152:medication combining rilpivirine with
1049:
717:
314:
289:
120:
2105:
1661:Antimicrobial Agents and Chemotherapy
1518:
665:
624:
616:
596:
588:
302:
137:
88:
2097:. U.S. National Library of Medicine.
2085:. U.S. National Library of Medicine.
1416:European Journal of Medical Research
671:
249:
238:
227:
214:
2765:Emtricitabine/tenofovir alafenamide
1460:10.1097/01.aids.0000242818.65215.bd
1252:human immunodeficiency virus type-1
1067:
916:compared with older NNRTIs such as
568:
560:
439:
24:
2780:Emtricitabine/tenofovir disoproxil
1017:
971:Contraindications and interactions
950:
25:
3232:
2071:
1170:emtricitabine/tenofovir/efavirenz
276:
169:
3183:
3171:
3153:. Formerly or rarely used agent.
2790:Lamivudine/nevirapine/zidovudine
2674:Abacavir/dolutegravir/lamivudine
2016:"FDA approves new HIV treatment"
1906:
1861:
1851:(Press release). 21 January 2021
1546:(Press release). 16 October 2020
1223:The tablets contain rilpivirine
757:
751:
47:
38:
2957:Epigallocatechin gallate (EGCG)
2800:Lamivudine/tenofovir disoproxil
2785:Lamivudine/nevirapine/stavudine
2045:"Rekambys: Pending EC decision"
2037:
2008:
1978:
1948:
1918:
1800:
1756:
1741:
1715:
1697:
1648:
1591:
1160:(TDF) was approved by the U.S.
1044:
923:
849:Key:KZVVGZKAVZUACK-BJILWQEISA-N
838:Key:YIBOMRUWOWDFLG-ONEGZZNKSA-N
2680:Abacavir/lamivudine/zidovudine
1483:
1434:
1382:
1319:
1294:
1268:
745:
13:
1:
1964:National Institutes of Health
1934:National Institutes of Health
1778:10.1016/S0140-6736(11)60936-7
1261:
880:, sold under the brand names
2020:Food and Drug Administration
1992:Food and Drug Administration
1892:Food and Drug Administration
1847:Food and Drug Administration
1814:Food and Drug Administration
1709:Food and Drug Administration
1207:
1194:Food and Drug Administration
1162:Food and Drug Administration
900:. It is a second-generation
896:, used for the treatment of
377:85% via faeces, 6% via urine
7:
2555:Tenofovir alafenamide (TAF)
2091:"Rilpivirine hydrochloride"
10:
3237:
2550:Tenofovir disoproxil (TDF)
1230:
1192:In January 2021, the U.S.
1053:
735:Chemical and physical data
3110:
3025:
2919:
2901:
2883:
2865:
2846:
2839:
2818:
2659:
2606:
2580:
2571:Discovery and development
2563:
2446:
2434:
2397:
2351:
2342:Discovery and development
2334:
2306:
2256:
2178:Discovery and development
2170:
2152:
2050:European Medicines Agency
1748:Haberfeld H, ed. (2021).
1642:European Medicines Agency
1606:European Medicines Agency
1585:European Medicines Agency
1542:European Medicines Agency
1392:. Tibotec. Archived from
1366:European Medicines Agency
1332:European Medicines Agency
1248:European Medicines Agency
1237:phase III clinical trials
857:
821:
801:
779:
766:
739:
734:
715:
683:
655:
635:
607:
579:
551:
523:
495:
467:
434:
406:
386:
381:
371:
356:
344:
334:
326:
266:
261:
201:
183:
157:
110:
96:
78:
70:
60:
55:
46:
37:
2867:Transcription inhibitors
2819:Pharmacokinetic boosters
2735:Dolutegravir/rilpivirine
2696:Cabotegravir/rilpivirine
2336:Protease Inhibitors (PI)
1242:On 15 October 2020, the
1198:cabotegravir/rilpivirine
1187:Dolutegravir/rilpivirine
941:antiretroviral treatment
3151:initial regimen options
2717:Dolutegravir/lamivudine
2194:Enfuvirtide (ENF, T-20)
2172:Entry/fusion inhibitors
2095:Drug Information Portal
2083:Drug Information Portal
1711:(FDA). August 10, 2011.
1144:Fixed-dose combinations
961:intramuscular injection
959:) and as a long-acting
2992:Portmanteau inhibitors
2885:Translation inhibitors
2795:Lamivudine/raltegravir
2565:Non-nucleoside (NNRTI)
2523:Islatravir (EFdA, ISL)
2018:(Press release). U.S.
1523:. Accessed 2021-02-23.
1390:"TMC278 — A new NNRTI"
1140:
1012:proton pump inhibitors
367:injection: 13–28 weeks
3007:Synergistic enhancers
2805:Lamivudine/zidovudine
2685:Atazanavir/cobicistat
2661:Combined formulations
2498:Zidovudine (AZT, ZDV)
2436:Reverse-transcriptase
2308:Maturation inhibitors
2022:(FDA). Archived from
1177:tenofovir alafenamide
1118:
1060:Rilpivirine is a non-
1054:Further information:
2848:Uncoating inhibitors
2701:Darunavir/cobicistat
2541:Nucleotide analogues
2459:Nucleoside analogues
2258:Integrase inhibitors
2137:antiretroviral drugs
1673:10.1128/AAC.01401-13
1498:on October 19, 2007.
1235:Rilpivirine entered
1158:tenofovir disoproxil
1106:biological half-life
1025:depressive disorders
904:(NNRTI) with higher
2840:Experimental agents
2810:Lopinavir/ritonavir
2669:Abacavir/lamivudine
2643:Elsulfavirine (ESV)
2478:Emtricitabine (FTC)
2364:Fosamprenavir (FPV)
1084:(99.7%), mostly to
1050:Mechanism of action
914:side-effect profile
298:(Prescription only)
285:(Prescription only)
34:
3137:Never to phase III
2283:Elvitegravir (EVG)
2278:Dolutegravir (DTG)
2273:Cabotegravir (CAB)
1960:ClinicalTrials.gov
1936:. October 25, 2012
1930:ClinicalTrials.gov
1818:. 29 November 2016
1336:. 12 December 2011
1141:
30:
3159:
3158:
3106:
3105:
2952:Diarylpyrimidines
2655:
2654:
2651:
2650:
2631:Rilpivirine (RPV)
2615:diarylpyrimidines
2598:Delavirdine (DLV)
2493:Zalcitabine (ddC)
2450:nucleotide (NRTI)
2430:
2429:
2288:Raltegravir (RAL)
2268:Bictegravir (BIC)
2247:Fostemsavir (FTR)
2162:Lenacapavir (LEN)
2154:Capsid inhibitors
2054:. 16 October 2020
1896:. 27 January 2021
1772:(9787): 238–246.
1667:(10): 5067–5079.
1453:(13): 1721–1726.
1370:. 13 October 2020
1282:. 21 January 2020
979:the liver enzyme
875:
874:
792:Interactive image
685:CompTox Dashboard
365:tablets: 45 hours
318:
306:
293:
280:
173:
140:
123:
66:Edurant, Rekambys
16:(Redirected from
3228:
3188:
3187:
3176:
3175:
3174:
3167:
2977:Hydroxycarbamide
2844:
2843:
2638:Doravirine (DOR)
2626:Etravirine (ETR)
2621:Dapivirine (DPV)
2593:Nevirapine (NVP)
2578:
2577:
2483:Lamivudine (3TC)
2473:Didanosine (ddI)
2444:
2443:
2417:Tipranavir (TPV)
2405:Atazanavir (ATV)
2389:Saquinavir (SQV)
2379:Nelfinavir (NFV)
2359:Amprenavir (APV)
2349:
2348:
2231:Ibalizumab (IBA)
2126:
2119:
2112:
2103:
2102:
2098:
2086:
2065:
2063:
2061:
2059:
2041:
2035:
2034:
2032:
2031:
2012:
2006:
2005:
2003:
2001:
1996:. 20 August 2013
1982:
1976:
1975:
1973:
1971:
1952:
1946:
1945:
1943:
1941:
1922:
1916:
1910:
1909:
1905:
1903:
1901:
1882:
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1858:
1856:
1837:
1828:
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1804:
1798:
1797:
1760:
1754:
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1745:
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1719:
1713:
1712:
1701:
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1684:
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1639:
1631:
1610:
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1603:
1595:
1589:
1588:
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1574:
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1555:
1553:
1551:
1533:
1524:
1522:
1515:
1500:
1499:
1487:
1481:
1480:
1462:
1438:
1432:
1431:
1411:
1405:
1404:
1402:
1401:
1386:
1380:
1379:
1377:
1375:
1357:
1346:
1345:
1343:
1341:
1323:
1317:
1316:
1314:
1312:
1298:
1292:
1291:
1289:
1287:
1272:
1218:diarylpyrimidine
1096:include several
1068:Pharmacokinetics
871:
870:
863:
794:
774:
759:
753:
747:
730:
719:
708:
707:
693:
691:
675:
669:
648:
628:
620:
600:
592:
572:
564:
544:
536:
516:
508:
488:
480:
460:
452:
442:
441:
427:
419:
361:
316:
313:
304:
301:
291:
288:
278:
275:
253:
242:
231:
218:
171:
168:
150:
139:
136:
133:
122:
119:
106:
92:
51:
42:
35:
33:
29:
21:
3236:
3235:
3231:
3230:
3229:
3227:
3226:
3225:
3196:
3195:
3194:
3182:
3172:
3170:
3162:
3160:
3155:
3154:
3142:
3127:Clinical trials
3102:
3053:Dexelvucitabine
3021:
3012:Tre recombinase
2915:
2897:
2879:
2875:Tat antagonists
2861:
2835:
2814:
2647:
2602:
2588:Efavirenz (EFV)
2567:
2559:
2488:Stavudine (d4T)
2449:
2437:
2426:
2411:Darunavir (DRV)
2393:
2384:Ritonavir (RTV)
2374:Lopinavir (LPV)
2369:Indinavir (IDV)
2338:
2330:
2302:
2260:
2252:
2206:Maraviroc (MVC)
2174:
2166:
2148:
2133:Antiviral drugs
2130:
2089:
2077:
2074:
2069:
2068:
2057:
2055:
2043:
2042:
2038:
2029:
2027:
2014:
2013:
2009:
1999:
1997:
1984:
1983:
1979:
1969:
1967:
1954:
1953:
1949:
1939:
1937:
1924:
1923:
1919:
1907:
1899:
1897:
1884:
1883:
1874:
1862:
1854:
1852:
1839:
1838:
1831:
1821:
1819:
1806:
1805:
1801:
1761:
1757:
1746:
1742:
1732:
1730:
1721:
1720:
1716:
1703:
1702:
1698:
1653:
1649:
1637:
1633:
1632:
1613:
1601:
1597:
1596:
1592:
1580:
1576:
1575:
1560:
1549:
1547:
1535:
1534:
1527:
1516:
1503:
1488:
1484:
1439:
1435:
1412:
1408:
1399:
1397:
1388:
1387:
1383:
1373:
1371:
1361:"Rekambys EPAR"
1359:
1358:
1349:
1339:
1337:
1325:
1324:
1320:
1310:
1308:
1300:
1299:
1295:
1285:
1283:
1274:
1273:
1269:
1264:
1233:
1210:
1196:(FDA) approved
1146:
1133:glucuronidizing
1082:plasma proteins
1070:
1058:
1052:
1047:
1039:QT prolongation
1020:
1018:Adverse effects
973:
953:
951:Available forms
926:
892:, developed by
866:
864:
861:(what is this?)
858:
853:
850:
845:
842:
839:
834:
829:
828:
817:
814:
809:
808:
797:
772:
762:
756:
750:
711:
687:
679:
651:
631:
603:
575:
547:
519:
491:
463:
438:
430:
402:
399:
394:
393:
366:
359:
336:Protein binding
328:Pharmacokinetic
322:
257:
244:
233:
222:
220:
186:
179:
160:
153:
28:
23:
22:
15:
12:
11:
5:
3234:
3224:
3223:
3218:
3213:
3208:
3193:
3192:
3180:
3157:
3156:
3141:
3140:
3139:
3138:
3135:
3124:
3118:
3112:
3111:
3108:
3107:
3104:
3103:
3101:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3029:
3027:
3023:
3022:
3020:
3019:
3014:
3009:
3004:
2999:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2923:
2921:
2917:
2916:
2914:
2913:
2907:
2905:
2899:
2898:
2896:
2895:
2889:
2887:
2881:
2880:
2878:
2877:
2871:
2869:
2863:
2862:
2860:
2859:
2852:
2850:
2841:
2837:
2836:
2834:
2833:
2828:
2826:Cobicistat (c)
2822:
2820:
2816:
2815:
2813:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2726:
2720:
2714:
2709:
2703:
2698:
2693:
2687:
2682:
2677:
2671:
2665:
2663:
2657:
2656:
2653:
2652:
2649:
2648:
2646:
2645:
2640:
2635:
2634:
2633:
2628:
2623:
2610:
2608:
2604:
2603:
2601:
2600:
2595:
2590:
2584:
2582:
2575:
2561:
2560:
2558:
2557:
2552:
2536:
2535:
2530:
2525:
2520:
2515:
2510:
2505:
2500:
2495:
2490:
2485:
2480:
2475:
2470:
2468:Abacavir (ABC)
2454:
2452:
2448:Nucleoside and
2441:
2432:
2431:
2428:
2427:
2425:
2424:
2419:
2414:
2408:
2401:
2399:
2395:
2394:
2392:
2391:
2386:
2381:
2376:
2371:
2366:
2361:
2355:
2353:
2346:
2332:
2331:
2329:
2328:
2323:
2318:
2312:
2310:
2304:
2303:
2301:
2300:
2295:
2290:
2285:
2280:
2275:
2270:
2264:
2262:
2254:
2253:
2251:
2250:
2238:
2222:
2208:
2197:
2184:
2182:
2168:
2167:
2165:
2164:
2158:
2156:
2150:
2149:
2129:
2128:
2121:
2114:
2106:
2100:
2099:
2087:
2073:
2072:External links
2070:
2067:
2066:
2036:
2007:
1977:
1966:. May 14, 2012
1947:
1917:
1872:
1829:
1799:
1755:
1740:
1714:
1696:
1647:
1611:
1590:
1558:
1525:
1501:
1482:
1433:
1422:(9): 483–495.
1406:
1381:
1347:
1327:"Edurant EPAR"
1318:
1293:
1266:
1265:
1263:
1260:
1246:(CHMP) of the
1232:
1229:
1209:
1206:
1145:
1142:
1069:
1066:
1051:
1048:
1046:
1043:
1019:
1016:
997:St John's wort
972:
969:
952:
949:
925:
922:
873:
872:
855:
854:
852:
851:
848:
846:
843:
840:
837:
835:
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824:
823:
822:
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795:
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760:
754:
748:
743:
737:
736:
732:
731:
721:
713:
712:
710:
709:
701:DTXSID10198189
696:
694:
681:
680:
678:
677:
661:
659:
653:
652:
650:
649:
641:
639:
633:
632:
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604:
602:
601:
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583:
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471:
465:
464:
462:
461:
453:
445:
443:
432:
431:
429:
428:
420:
412:
410:
404:
403:
401:
400:
397:
389:
388:
387:
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383:
379:
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375:
369:
368:
363:
354:
353:
348:
342:
341:
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331:
324:
323:
321:
320:
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299:
286:
272:
270:
264:
263:
259:
258:
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207:
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181:
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134:
116:
114:
108:
107:
100:
94:
93:
86:
76:
75:
72:
68:
67:
64:
58:
57:
53:
52:
44:
43:
26:
9:
6:
4:
3:
2:
3233:
3222:
3219:
3217:
3214:
3212:
3209:
3207:
3204:
3203:
3201:
3191:
3186:
3181:
3179:
3169:
3168:
3165:
3152:
3149:
3146:
3136:
3134:
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3130:
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3125:
3122:
3119:
3117:
3114:
3113:
3109:
3099:
3096:
3094:
3091:
3089:
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3084:
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3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3030:
3028:
3026:Failed agents
3024:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2925:
2924:
2922:
2918:
2912:
2909:
2908:
2906:
2904:
2900:
2894:
2893:Trichosanthin
2891:
2890:
2888:
2886:
2882:
2876:
2873:
2872:
2870:
2868:
2864:
2857:
2854:
2853:
2851:
2849:
2845:
2842:
2838:
2832:
2831:Ritonavir (r)
2829:
2827:
2824:
2823:
2821:
2817:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2730:
2727:
2724:
2721:
2718:
2715:
2713:
2710:
2707:
2704:
2702:
2699:
2697:
2694:
2691:
2688:
2686:
2683:
2681:
2678:
2675:
2672:
2670:
2667:
2666:
2664:
2662:
2658:
2644:
2641:
2639:
2636:
2632:
2629:
2627:
2624:
2622:
2619:
2618:
2617:
2616:
2612:
2611:
2609:
2605:
2599:
2596:
2594:
2591:
2589:
2586:
2585:
2583:
2579:
2576:
2574:
2572:
2566:
2562:
2556:
2553:
2551:
2548:
2546:
2542:
2538:
2537:
2534:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2509:
2506:
2504:
2501:
2499:
2496:
2494:
2491:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
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2456:
2455:
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2451:
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2412:
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2357:
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2354:
2350:
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2345:
2343:
2337:
2333:
2327:
2324:
2322:
2319:
2317:
2314:
2313:
2311:
2309:
2305:
2299:
2296:
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2279:
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2274:
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2259:
2255:
2248:
2244:
2243:
2239:
2236:
2232:
2228:
2227:
2223:
2220:
2216:
2212:
2209:
2207:
2203:
2202:
2198:
2195:
2191:
2190:
2186:
2185:
2183:
2181:
2179:
2173:
2169:
2163:
2160:
2159:
2157:
2155:
2151:
2146:
2142:
2139:used against
2138:
2134:
2127:
2122:
2120:
2115:
2113:
2108:
2107:
2104:
2096:
2092:
2088:
2084:
2080:
2079:"Rilpivirine"
2076:
2075:
2053:
2051:
2046:
2040:
2026:on 2017-01-18
2025:
2021:
2017:
2011:
1995:
1993:
1987:
1981:
1965:
1961:
1957:
1951:
1935:
1931:
1927:
1921:
1914:
1913:public domain
1895:
1893:
1887:
1881:
1879:
1877:
1869:
1868:public domain
1850:
1848:
1842:
1836:
1834:
1817:
1815:
1809:
1803:
1795:
1791:
1787:
1783:
1779:
1775:
1771:
1767:
1759:
1751:
1750:Austria-Codex
1744:
1728:
1724:
1718:
1710:
1706:
1700:
1692:
1688:
1683:
1678:
1674:
1670:
1666:
1662:
1658:
1651:
1644:. 2021-01-04.
1643:
1636:
1630:
1628:
1626:
1624:
1622:
1620:
1618:
1616:
1608:. 2021-01-05.
1607:
1600:
1594:
1587:. 2021-02-22.
1586:
1579:
1573:
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1565:
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1538:
1532:
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1521:
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1510:
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1506:
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1486:
1478:
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1470:
1466:
1461:
1456:
1452:
1448:
1444:
1437:
1429:
1425:
1421:
1417:
1410:
1396:on 2008-12-20
1395:
1391:
1385:
1369:
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1356:
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1352:
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1333:
1328:
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1277:
1271:
1267:
1259:
1257:
1253:
1249:
1245:
1240:
1238:
1228:
1226:
1225:hydrochloride
1221:
1219:
1215:
1205:
1203:
1199:
1195:
1190:
1188:
1184:
1182:
1178:
1173:
1171:
1167:
1163:
1159:
1155:
1154:emtricitabine
1151:
1138:
1134:
1130:
1126:
1122:
1117:
1113:
1109:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1078:
1075:
1065:
1063:
1057:
1042:
1040:
1036:
1034:
1030:
1026:
1015:
1013:
1008:
1006:
1002:
998:
994:
990:
986:
985:carbamazepine
982:
978:
968:
966:
962:
958:
948:
946:
942:
938:
933:
931:
921:
919:
915:
911:
907:
903:
899:
895:
891:
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883:
879:
869:
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836:
831:
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827:
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811:
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800:
793:
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788:
786:
783:
778:
771:
769:
765:
744:
742:
738:
733:
729:
725:
722:
720:
718:ECHA InfoCard
714:
706:
702:
698:
697:
695:
686:
682:
674:
673:RCSB PDB
668:
663:
662:
660:
658:
654:
647:
643:
642:
640:
638:
634:
627:
626:ChEMBL1628504
623:as HCl:
622:
619:
615:
614:
612:
610:
606:
599:
595:as HCl:
594:
591:
587:
586:
584:
582:
578:
571:
567:as HCl:
566:
563:
559:
558:
556:
554:
550:
543:
539:as HCl:
538:
535:
531:
530:
528:
526:
522:
515:
511:as HCl:
510:
507:
503:
502:
500:
498:
494:
487:
483:as HCl:
482:
479:
475:
474:
472:
470:
466:
459:
455:as HCl:
454:
451:
447:
446:
444:
437:
433:
426:
422:as HCl:
421:
418:
414:
413:
411:
409:
405:
396:
395:
392:
385:
380:
376:
374:
370:
364:
362:
355:
352:
349:
347:
343:
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337:
333:
329:
325:
319: Rx-only
312:
310:
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297:
287:
284:
274:
273:
271:
269:
265:
260:
252:
247:
241:
236:
230:
225:
221:combinations:
217:
212:
209:
208:
206:
204:
200:
197:
196:intramuscular
193:
190:
188:
182:
176:
167:
166:
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162:
156:
149:
144:
135:
132:
127:
118:
117:
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109:
105:
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99:
95:
91:
87:
85:
81:
77:
73:
69:
65:
63:
59:
56:Clinical data
54:
50:
45:
41:
36:
27:HIV treatment
19:
3147:
2947:Cyanovirin-N
2937:Calanolide A
2630:
2613:
2607:2 generation
2581:1 generation
2568:
2539:
2518:Elvucitabine
2508:Apricitabine
2457:
2398:2 generation
2352:1 generation
2339:
2326:Fipravirimat
2240:
2235:Semzuvolimab
2224:
2215:Cenicriviroc
2199:
2187:
2175:
2094:
2082:
2056:. Retrieved
2048:
2039:
2028:. Retrieved
2024:the original
2010:
1998:. Retrieved
1989:
1980:
1968:. Retrieved
1959:
1950:
1938:. Retrieved
1929:
1920:
1898:. Retrieved
1889:
1853:. Retrieved
1844:
1820:. Retrieved
1811:
1802:
1769:
1765:
1758:
1749:
1743:
1733:September 1,
1731:. Retrieved
1729:. March 2011
1717:
1699:
1664:
1660:
1650:
1593:
1548:. Retrieved
1540:
1517:Rilpivirine
1496:the original
1485:
1450:
1446:
1436:
1419:
1415:
1409:
1398:. Retrieved
1394:the original
1384:
1372:. Retrieved
1364:
1338:. Retrieved
1330:
1321:
1309:. Retrieved
1305:
1296:
1284:. Retrieved
1279:
1270:
1256:cabotegravir
1241:
1234:
1222:
1211:
1202:cabotegravir
1191:
1185:
1174:
1147:
1110:
1102:glucuronides
1079:
1074:blood plasma
1071:
1059:
1045:Pharmacology
1037:
1021:
1009:
974:
964:
956:
954:
937:cabotegravir
934:
927:
924:Medical uses
912:and reduced
885:
881:
877:
876:
865:
859:
637:NIAID ChemDB
618:ChEMBL175691
486:DBSALT000152
358:Elimination
268:Legal status
262:Legal status
112:License data
3216:Pyrimidines
3148:recommended
3123:from market
3073:Lersivirine
3048:Capravirine
2987:Miltefosine
2972:Griffithsin
2967:Fosdevirine
2513:Censavudine
2143:(primarily
1094:Metabolites
878:Rilpivirine
775: g·mol
724:100.224.394
598:CHEBI:68602
590:CHEBI:68606
425:700361-47-3
417:500287-72-9
382:Identifiers
148:Rilpivirine
98:MedlinePlus
71:Other names
62:Trade names
32:Rilpivirine
3200:Categories
3078:Lodenosine
3058:Droxinavir
3043:Brecanavir
3038:Atevirdine
3002:Seliciclib
2997:Scytovirin
2911:Elipovimab
2856:TRIM5alpha
2533:Stampidine
2438:inhibitors
2422:TMC-310911
2321:BMS-955176
2219:Leronlimab
2211:Vicriviroc
2058:16 October
2030:2011-05-20
2000:23 January
1970:January 1,
1940:January 1,
1900:27 January
1855:21 January
1822:23 January
1723:"Eviplera"
1550:16 October
1400:2010-03-07
1262:References
1214:etravirine
1150:fixed-dose
1131:) and the
1100:products,
1062:nucleoside
1001:resistance
993:rifampicin
983:, such as
930:viral load
890:medication
780:3D model (
768:Molar mass
657:PDB ligand
542:212WAX8KDD
534:FI96A8X663
497:ChemSpider
408:CAS Number
391:IUPAC name
346:Metabolism
3133:Phase III
3121:Withdrawn
3098:Telinavir
3093:Palinavir
3088:Mozenavir
3068:Emivirine
3063:Lasinavir
3033:Aplaviroc
2962:Foscarnet
2942:Ceragenin
2503:Amdoxovir
2316:Bevirimat
2293:BI 224436
1520:Monograph
1374:4 January
1340:4 January
1311:4 January
1286:4 January
1208:Chemistry
1121:oxidizing
1098:oxidation
989:phenytoin
918:efavirenz
910:half-life
908:, longer
373:Excretion
360:half-life
185:Routes of
159:Pregnancy
90:Monograph
84:Drugs.com
3211:Nitriles
3178:Medicine
3083:Loviride
1786:21763936
1691:23917319
1477:26078073
1469:16931936
1428:17933730
1306:DailyMed
1220:(DAPY).
1166:Complera
1029:insomnia
965:Rekambys
898:HIV/AIDS
886:Rekambys
868:(verify)
469:DrugBank
458:11711114
203:ATC code
192:By mouth
174: B1
161:category
143:DailyMed
3190:Viruses
3164:Portals
2982:KP-1461
2528:Racivir
2298:MK-2048
1794:7313885
1727:Aidsmap
1707:. U.S.
1682:3811466
1231:History
1181:Odefsey
1135:enzyme
1123:enzyme
1086:albumin
957:Edurant
906:potency
894:Tibotec
888:, is a
882:Edurant
773:366.428
741:Formula
514:9885836
506:4953643
478:DB08864
450:6451164
436:PubChem
248: (
246:J05AR08
237: (
235:J05AR21
226: (
224:J05AR19
219:)
213: (
211:J05AG05
145::
128::
104:a611037
18:Edurant
3116:WHO-EM
2932:BIT225
2927:Abzyme
2858:(gene)
2545:NtRTIs
2440:(RTIs)
1792:
1784:
1766:Lancet
1689:
1679:
1475:
1467:
1426:
1137:UGT1A1
1129:CYP3A5
1125:CYP3A4
1090:CYP3A4
1033:rashes
1031:, and
1005:UGT1A1
995:, and
981:CYP3A4
977:induce
806:SMILES
646:169030
609:ChEMBL
570:D09958
562:D09720
351:CYP3A4
309:℞-only
307:
294:
281:
141:
131:by INN
124:
74:TMC278
2920:Other
2903:BNAbs
2463:NRTIs
2242:gp120
2052:(EMA)
1994:(FDA)
1990:U.S.
1894:(FDA)
1890:U.S.
1849:(FDA)
1845:U.S.
1816:(FDA)
1812:U.S.
1790:S2CID
1638:(PDF)
1602:(PDF)
1581:(PDF)
1544:(EMA)
1473:S2CID
1368:(EMA)
1334:(EMA)
1280:(emc)
1212:Like
1127:(and
826:InChI
782:JSmol
664:T27 (
581:ChEBI
340:99.7%
3145:DHHS
2201:CCR5
2189:gp41
2060:2020
2002:2021
1972:2014
1942:2014
1902:2021
1857:2021
1824:2021
1782:PMID
1735:2014
1687:PMID
1552:2020
1465:PMID
1447:AIDS
1424:PMID
1376:2021
1342:2021
1313:2021
1288:2021
1156:and
884:and
667:PDBe
553:KEGG
525:UNII
330:data
80:AHFS
2226:CD4
2145:J05
2141:HIV
1774:doi
1770:378
1677:PMC
1669:doi
1455:doi
690:EPA
440:CID
296:POM
251:WHO
240:WHO
229:WHO
216:WHO
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