797:
809:
383:. These channels are found predominantly in smaller sensory neurons in the dorsal root ganglion cells and are activated by higher pressures, two attributes that are characteristic of nociceptors. Also, the threshold of HT channels was lowered in the presence of PGE2 (a compound that sensitizes neurons to mechanical stimuli and mechanical hyperalgesia) which further supports a role for HT channels in the transduction of mechanical stimuli into nociceptive neuronal signals.
821:
29:
56:
370:
have been found in the posterior root ganglion neurons. The two channels are broadly classified as either high-threshold (HT) or low threshold (LT). As their names suggest, they have different thresholds as well as different sensitivities to pressure. These are cationic channels whose activity
371:
appears to be regulated by the proper functioning of the cytoskeleton and cytoskeleton associated proteins. The presence of these channels in the posterior root ganglion gives reason to believe that other sensory neurons may contain them as well.
650:
Sugawara, O.; Atsuta, Y.; Iwahara, T.; Muramoto, T.; Watakabe, M.; Takemitsu, Y. (1996). "The effects of mechanical compression and hypoxia on nerve root and dorsal root ganglia. An analysis of ectopic firing using an in vitro model".
351:
The nerve endings of dorsal root ganglion neurons have a variety of sensory receptors that are activated by mechanical, thermal, chemical, and noxious stimuli. In these sensory neurons, a group of
279:
The distal section of the axon may either be a bare nerve ending or encapsulated by a structure that helps relay specific information to nerve. Two examples where the nerve ending of the
359:
transduction have been identified. Compression of the dorsal root ganglion by a mechanical stimulus lowers the voltage threshold needed to evoke a response and causes
864:
445:(also known as sensory ganglionopathy): A heterogenous group of causes leading to nerves in the dorsal root ganglion being destroyed causing sensory symptoms.
141:
486:
Purves, Dale; Augustine, George J.; Fitzpatrick, David; Katz, Lawrence C.; LaMantia, Anthony-Samuel; McNamara, James O.; Williams, S. Mark (2001).
808:
837:
849:
117:
336:
892:
60:
A spinal nerve with its ventral and dorsal roots. The dorsal root ganglion is the "spinal ganglion", following the dorsal root.
694:
Syriatowicz, J. P.; Hu, D.; Walker, J. S.; Tracey, D. J. (1999). "Hyperalgesia due to nerve injury: Role of prostaglandins".
323:. Hence, the spinal ganglia can be regarded as gray matter of the spinal cord that became translocated to the periphery.
307:. The anterior and posterior spinal nerve roots join just beyond (lateral) to the location of the dorsal root ganglion.
1716:
820:
391:
The presynaptic regulation of the dorsal nerve ending discharge in the spinal cord can occur through certain types of
525:
1516:
1446:
737:
Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De
Koninck Y (June 2014).
1511:
1441:
1056:
796:
236:
type, meaning they have a cell body (soma) with two branches that act as a single axon, often referred to as a
1131:
432:
268:
136:
1126:
1114:
885:
516:
367:
1166:
1104:
739:"Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABA
1161:
488:"The Major Afferent Pathway for Mechanosensory Information: The Dorsal Column-Medial Lemniscus System"
1671:
1521:
1456:
1084:
209:
1451:
1177:
284:
100:
1150:
878:
304:
1618:
1145:
909:
538:
248:
233:
213:
148:
124:
112:
1711:
1476:
1466:
1401:
853:
843:
1601:
1498:
1428:
1254:
858:
442:
356:
205:
8:
1641:
1486:
1481:
1016:
949:
292:
194:
38:
539:"Nociceptors of dorsal root ganglion express proton-sensing G-protein-coupled receptors"
1676:
1646:
1577:
1546:
1536:
1531:
1526:
1471:
1247:
1157:
1011:
769:
738:
719:
676:
622:
613:
597:
569:
707:
1661:
1651:
1636:
1541:
1406:
1187:
1139:
944:
939:
774:
711:
668:
664:
627:
561:
521:
264:
723:
680:
573:
1628:
1591:
1586:
934:
764:
759:
754:
703:
660:
617:
609:
553:
412:
400:
360:
252:
1396:
1365:
1360:
1242:
1237:
1061:
105:
1686:
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1613:
1433:
1391:
1369:
1289:
1172:
996:
901:
511:
487:
404:
392:
557:
363:
to be fired. This firing may even persist after the removal of the stimulus.
1705:
1335:
1320:
1001:
129:
42:
598:"Mechanosensitive ion channels in cultured sensory neurons of neonatal rats"
259:
in the periphery, bypass the cell body, and continue to propagate along the
1581:
1503:
1416:
1297:
1227:
1006:
929:
778:
715:
631:
565:
339:
are expressed by DRG sensory neurons and might play a role in acid-induced
316:
190:
76:
672:
1596:
1411:
1315:
1273:
1205:
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1021:
959:
954:
924:
416:
380:
352:
340:
320:
221:
186:
462:
154:
1666:
1355:
1232:
1195:
814:
The formation of the spinal nerve from the posterior and anterior roots
212:, afferents refer to the axons that relay sensory information into the
71:
1681:
1215:
1066:
1039:
1031:
437:
1345:
1330:
1325:
1049:
1044:
971:
966:
182:
45:
1608:
1569:
1461:
870:
178:
28:
1268:
1223:
988:
34:
537:
Huang CW, Tzeng JN, Chen YJ, Tsai WF, Chen CC, Sun WH (2007).
485:
649:
217:
201:
88:
1307:
596:
Cho, H.; Shin, J.; Shin, C. Y.; Lee, S. Y.; Oh, U. (2002).
420:
374:
232:
The neurons comprising the dorsal root ganglion are of the
291:
of mechanosensory neurons sensitive to stroking only, and
55:
693:
736:
846: – Histology Learning System at Boston University
840:
at Human
Anatomy Online, SUNY Downstate Medical Center
255:
in posterior root ganglion neuron may initiate in the
37:(around stage of day 7) after incubation overnight in
403:
which are absent from these types of terminals. Thus
16:
Cluster of neurons in a dorsal root of a spinal nerve
520:, 4th ed., p.431–433. McGraw-Hill, New York (2000).
826:
Scheme showing structure of a typical spinal nerve.
315:The dorsal root ganglia develop in the embryo from
48:. Neurites growing out of the ganglion are visible.
536:
295:, which make neurons more sensitive to vibration.
1703:
379:High-threshold channels have a possible role in
595:
591:
589:
587:
585:
583:
193:. The cell bodies of sensory neurons known as
886:
645:
643:
641:
204:of dorsal root ganglion neurons are known as
346:
247:Unlike the majority of neurons found in the
33:A dorsal root ganglion (DRG) from a chicken
730:
580:
530:
893:
879:
638:
337:Proton-sensing G protein-coupled receptors
54:
27:
768:
758:
621:
197:are located in the dorsal root ganglia.
375:High-threshold mechanosensitive channels
1704:
386:
874:
788:
479:
303:The dorsal root ganglia lie in the
13:
900:
614:10.1523/JNEUROSCI.22-04-01238.2002
399:but not through the activation of
14:
1728:
831:
274:
94:ganglion sensorium nervi spinalis
819:
807:
795:
665:10.1097/00007632-199609150-00006
1057:Oligodendrocyte progenitor cell
760:10.1523/JNEUROSCI.0159-14.2014
687:
505:
455:
355:thought to be responsible for
331:
310:
1:
708:10.1016/S0306-4522(99)00365-6
449:
433:Anterior root of spinal nerve
368:mechanosensitive ion channels
283:is encapsulated as such are,
269:posterior horn of spinal cord
517:Principles of Neural Science
415:can presynaptically control
227:
7:
1167:Postganglionic nerve fibers
602:The Journal of Neuroscience
514:, Schwartz JH, Jessell TM.
426:
326:
298:
10:
1733:
1162:Preganglionic nerve fibers
1717:Peripheral nervous system
1672:Olfactory receptor neuron
1627:
1568:
1561:
1497:
1427:
1384:
1344:
1336:Neurofibril/neurofilament
1306:
1288:
1281:
1267:
1214:
1186:
1092:
1083:
1030:
987:
980:
917:
908:
844:Histology image: 04401loa
558:10.1016/j.mcn.2007.06.010
492:Neuroscience. 2nd edition
347:Mechanosensitive channels
210:peripheral nervous system
147:
135:
123:
111:
99:
87:
82:
70:
65:
53:
26:
21:
838:Anatomy figure: 02:04-09
305:intervertebral foramina
175:posterior root ganglion
1619:Neuromuscular junction
1482:III or Aδ or fast pain
366:Two distinct types of
249:central nervous system
214:central nervous system
149:Anatomical terminology
854:Ohio State University
285:Meissner's corpuscles
1637:Meissner's corpuscle
1602:Postsynaptic density
1499:Efferent nerve fiber
1487:IV or C or slow pain
1429:Afferent nerve fiber
1255:Satellite glial cell
443:Sensory neuronopathy
167:dorsal root ganglion
22:Dorsal root ganglion
1642:Merkel nerve ending
546:Mol. Cell. Neurosci
387:Presynaptic control
293:Pacinian corpuscles
287:, which render the
263:until reaching the
195:first-order neurons
1677:Photoreceptor cell
1647:Pacinian corpuscle
1578:Electrical synapse
1532:Lower motor neuron
1527:Upper motor neuron
1248:Internodal segment
1188:Connective tissues
1158:Autonomic ganglion
177:) is a cluster of
173:; also known as a
41:stained with anti-
1699:
1698:
1695:
1694:
1662:Free nerve ending
1629:Sensory receptors
1557:
1556:
1472:Ib or Golgi or Aα
1380:
1379:
1263:
1262:
1140:Ramus communicans
1079:
1078:
1075:
1074:
945:Commissural fiber
940:Association fiber
935:Projection fibers
861:at webanatomy.net
789:Additional images
659:(18): 2089–2094.
413:glycine receptors
401:glycine receptors
361:action potentials
265:synaptic terminal
163:
162:
158:
39:NGF growth medium
1724:
1592:Synaptic vesicle
1587:Chemical synapse
1566:
1565:
1286:
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1279:
1278:
1090:
1089:
985:
984:
915:
914:
895:
888:
881:
872:
871:
823:
811:
802:Medulla spinalis
799:
783:
782:
772:
762:
734:
728:
727:
691:
685:
684:
647:
636:
635:
625:
608:(4): 1238–1247.
593:
578:
577:
543:
534:
528:
509:
503:
502:
500:
498:
483:
477:
476:
474:
473:
459:
289:distal processes
261:proximal process
253:action potential
242:proximal process
155:edit on Wikidata
152:
58:
31:
19:
18:
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1700:
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1477:II or Aβ and Aγ
1432:
1423:
1376:
1366:Apical dendrite
1361:Dendritic spine
1340:
1302:
1272:
1259:
1243:Node of Ranvier
1238:Myelin incisure
1210:
1182:
1071:
1062:Oligodendrocyte
1045:Ependymal cells
1026:
976:
904:
899:
834:
827:
824:
815:
812:
803:
800:
791:
786:
753:(24): 8300–17.
742:
735:
731:
692:
688:
648:
639:
594:
581:
541:
535:
531:
510:
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396:
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234:pseudo-unipolar
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171:spinal ganglion
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17:
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5:
1730:
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1697:
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1687:Taste receptor
1684:
1679:
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1657:Muscle spindle
1654:
1652:Ruffini ending
1649:
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1625:
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1614:Ribbon synapse
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1479:
1474:
1469:
1459:
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1438:
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1434:Sensory neuron
1425:
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1422:
1421:
1420:
1419:
1409:
1404:
1402:Pseudounipolar
1399:
1394:
1388:
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1378:
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1372:
1370:Basal dendrite
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1323:
1321:Axon terminals
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1173:Nerve fascicle
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1148:
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1129:
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1107:
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1087:
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1080:
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962:
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927:
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902:Nervous tissue
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73:
69:
64:
57:
52:
47:
44:
43:neurofilament
40:
36:
30:
25:
20:
1712:Back anatomy
1582:Gap junction
1504:Motor neuron
1298:Axon hillock
1274:nerve fibers
1228:Schwann cell
1138:
1121:
1109:
1099:
1017:Medium spiny
930:White matter
918:Tissue Types
867:at uwlax.edu
750:
746:
732:
699:
696:Neuroscience
695:
689:
656:
652:
605:
601:
549:
545:
532:
515:
507:
495:. Retrieved
491:
481:
470:. Retrieved
466:
457:
390:
378:
365:
353:ion channels
350:
335:
317:neural crest
314:
302:
288:
280:
278:
260:
256:
246:
241:
237:
231:
199:
191:spinal nerve
174:
170:
166:
164:
118:A14.2.00.006
93:
77:Neural crest
1597:Active zone
1562:Termination
1412:Interneuron
1316:Telodendron
1224:Myelination
1206:Endoneurium
1201:Perineurium
1022:Interneuron
1012:Von Economo
960:Decussation
955:Nerve tract
925:Grey matter
747:J. Neurosci
467:Physiopedia
417:nociception
381:nociception
341:nociception
332:Nociception
321:neural tube
319:cells, not
311:Development
222:spinal cord
187:dorsal root
83:Identifiers
1706:Categories
1667:Nociceptor
1407:Multipolar
1356:Nissl body
1233:Neurilemma
1196:Epineurium
981:Cell Types
743:Receptors"
472:2021-05-15
463:"Ganglion"
450:References
216:(i.e. the
1682:Hair cell
1216:Neuroglia
1178:Funiculus
1067:Microglia
1040:Astrocyte
997:Pyramidal
950:Lemniscus
512:Kandel ER
438:Knee jerk
409:receptors
397:receptors
228:Structure
208:. In the
206:afferents
72:Precursor
1467:Ia or Aα
1397:Unipolar
1346:Dendrite
1331:Axolemma
1326:Axoplasm
1110:Ganglion
1050:Tanycyte
1002:Purkinje
989:Neuronal
972:Meninges
967:Neuropil
779:24920633
724:31565617
716:10579219
681:23961565
632:11850451
574:38351962
566:17720533
427:See also
411:but not
327:Function
299:Location
220:and the
183:ganglion
46:antibody
1609:Autapse
1570:Synapse
1417:Renshaw
1392:Bipolar
1269:Neurons
1122:Ventral
1093:General
1007:Granule
859:Diagram
770:6608243
673:8893432
623:6757581
267:in the
185:) in a
179:neurons
106:D005727
66:Details
1462:fibers
1100:Dorsal
777:
767:
722:
714:
679:
671:
630:
620:
572:
564:
524:
497:30 May
240:and a
35:embryo
1385:Types
1282:Parts
1151:White
1132:Ramus
1115:Ramus
1032:Glial
865:Photo
720:S2CID
677:S2CID
653:Spine
570:S2CID
542:(PDF)
251:, an
218:brain
202:axons
189:of a
153:[
89:Latin
1308:Axon
1290:Soma
1146:Gray
1127:Root
1105:Root
775:PMID
712:PMID
669:PMID
628:PMID
562:PMID
522:ISBN
499:2018
421:pain
419:and
405:GABA
393:GABA
200:The
169:(or
142:5888
130:6167
113:TA98
101:MeSH
1522:SVE
1517:GVE
1512:GSE
1457:SVA
1452:SSA
1447:GVA
1442:GSA
1085:PNS
910:CNS
852:at
765:PMC
755:doi
704:doi
661:doi
618:PMC
610:doi
554:doi
224:).
181:(a
137:FMA
125:TA2
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407:A
395:A
157:]
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