334:. In 1970, around one in 20 pregnant women were affected with the blood disease and approximately one in 1,000 babies died from the disease in England and Wales. By introducing anti-D prophylaxis, the number of deaths dropped to one by 1989. Tovey's data from the Yorkshire Regional Transfusion Centre reported the number of newborns affected by Rh disease was 267 in 1970, 103 in 1975, 84 in 1980, 52 in 1985, and 37 in 1989. The numbers of newborn deaths or stillbirths due to the disease was 66 in 1970, 14 in 1975, 7 in 1980, 2 in 1985 and 1 in 1989.
287:. Over the next three days a further eight cases of smallpox were detected among four hospitals in Bradford and a convalescent hospital outside the city. Tovey was subsequently put in charge of infection control at St Luke's and given the responsibility of liaising with the medical officers of health and the press. For the next three weeks he would be confined to the hospital under quarantine, while his wife was pregnant with their second child. The outbreak ended the following month following a system of
275:, Bradford, having moved with his wife Kay to Yorkshire. On 11 January he received two identical blood samples from two unrelated severely ill people from two different hospitals. After consulting a colleague and looking back through historical texts, he recognised the blood samples as compatible with that seen with smallpox, as reported by
195:. Over the subsequent three days a further eight cases of smallpox were detected and Tovey subsequently became in charge of infection control at St Luke's and given the responsibility of liaising with the medical officers of health and the press. He later attributed the successful containment of the outbreak to effective
317:
in Leeds. In 1966 he was appointed director of the
Yorkshire Region Transfusion Centre, where he remained until 1988, and from 1980 to 1988 he was chairman of the anti-D working party Department of Health and Social Security. It was from Seacroft that he introduced the administration of
303:
This ‘success’ was due primarily to the fact that a small group of regional and local doctors, nurses and administrators had the authority and drive to introduce immediate measures to tackle the outbreak, to set in motion exhaustive tracing of contacts, and to initiate ring local mass
33:
210:
From 1966 to 1988 he was director of the
Yorkshire Region Transfusion Centre, and from 1980 to 1988 he was chairman of the anti-D working party Department of Health and Social Security. His contributions led to the routine use of
872:
867:
223:
in the UK. His data from the
Yorkshire Regional Transfusion Centre showed that by introducing anti-D prophylaxis, the number of deaths in newborns due to
857:
730:
862:
713:
338:
461:"Oliver memorial lecture. Towards the conquest of Rh haemolytic disease: Britain's contribution and the role of serendipity"
361:"Suppression of early rhesus sensitization by passive anti-D immunoglobulin: suppression of early rhesus sensitization"
280:
192:
96:
681:
544:
272:
176:
139:
877:
283:. The index case was shortly found to be a nine-year old girl who had died earlier of suspected
319:
240:
212:
102:
701:
755:
244:
75:
852:
847:
8:
239:, where he lived with his parents above their grocery store. Following inspiration as a
818:
785:
642:
609:
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496:
476:
442:
409:
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106:
823:
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647:
629:
579:
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314:
248:
144:
500:
400:
813:
797:
637:
621:
559:
472:
437:
421:
372:
349:
Tovey died on 16 November 2015. He and his wife Kay had two sons and one daughter.
279:
in 1925. The cases became the first laboratory confirmed cases of smallpox in the
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196:
625:
425:
337:
He retired in his 60s and travelled to
Adelaide, Australia, where he worked at
184:
841:
809:
633:
571:
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384:
827:
651:
460:
360:
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200:
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220:
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110:
331:
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299:. In his account of the outbreak, published in 2004, he recalled:
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236:
873:
Fellows of the Royal
College of Obstetricians and Gynaecologists
313:
From St Luke's he took up a post as consultant haematologist at
32:
731:"Looking back: When Bradford sport was shut down by smallpox"
610:"The Bradford smallpox outbreak in 1962: a personal account"
255:, London. His training had been in all branches of general
247:
to study medicine and later took up an appointment as a
171:
FRCPath, FRCOG (1926 – 16 November 2015), was a
British
243:
cadet when in his teens, he gained admission to the
756:"Derrick Tovey | The History of Modern Biomedicine"
271:In January 1962, he was a fairly new consultant at
839:
674:The Last Days of Smallpox; Tragedy in Birmingham
175:who shortly after being appointed consultant at
95:Diagnosing first early cases of smallpox in the
414:British Medical Journal (Clinical Research Ed.)
359:Tovey, L. A.; Scott, J. S. (September 1980).
868:Fellows of the Royal College of Pathologists
667:
665:
663:
661:
708:. Palgrave Macmillan UK. pp. 315–318.
230:
695:
693:
672:Pallen, Mark (2018). "10. Bradford 1962".
538:
358:
31:
817:
786:"Forty years of anti-D immunoprophylaxis"
658:
641:
536:
534:
532:
530:
528:
526:
524:
522:
520:
518:
441:
227:dropped from 66 in 1970 to one by 1989.
187:, England, recognised the first cases of
777:
699:
614:Journal of the Royal Society of Medicine
352:
59:16 November 2015 (aged 88–89)
690:
603:
601:
599:
597:
595:
593:
591:
589:
542:
332:Rh haemolytic disease in their newborns
840:
748:
728:
671:
515:
465:Transfusion Medicine (Oxford, England)
783:
706:Angel of Death: The Story of Smallpox
607:
458:
407:
281:1962 outbreak of smallpox in Bradford
101:Introducing routine use in the UK of
586:
858:Alumni of the University of Bristol
13:
543:Gulland, Anne (23 December 2015).
477:10.1111/j.1365-3148.1992.tb00142.x
377:10.1111/j.1423-0410.1980.tb01850.x
235:Derrick Tovey was born in 1926 in
193:Bradford smallpox outbreak of 1962
97:Bradford smallpox outbreak of 1962
14:
889:
408:Tovey, L. A. (15 October 1988).
784:Reali, Giorgio (January 2007).
729:Parker, Simon (13 April 2020).
339:Women's and Children's Hospital
308:
266:
722:
1:
508:
863:Medical doctors from Bristol
735:Bradford Telegraph and Argus
315:Seacroft Children’s Hospital
145:Seacroft Children’s Hospital
7:
608:Tovey, Derrick (May 2004).
10:
894:
626:10.1177/014107680409700512
459:Tovey, L. A. (June 1992).
426:10.1136/bmj.297.6654.977-a
169:Lucas Alfred Derrick Tovey
44:Lucas Alfred Derrick Tovey
700:Williams, Gareth (2010).
410:"Anti-D and miscarriages"
191:in the early days of the
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125:
118:
89:
81:
71:
63:
55:
39:
30:
23:
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231:Early life and education
552:British Medical Journal
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763:www.histmodbiomed.org
353:Selected publications
320:anti-D immunoglobulin
301:
245:University of Bristol
76:University of Bristol
878:English pathologists
802:10.2450/2007.0b18-06
702:"14. Lest we forget"
326:in mothers who are
324:RhD isoimmunization
241:St John's Ambulance
219:in mothers who are
217:RhD isoimmunization
109:in mothers who are
107:RhD isoimmunization
16:British pathologist
676:. pp. 29–32.
273:St Luke's Hospital
253:Middlesex Hospital
177:St Luke's Hospital
140:St Luke's Hospital
790:Blood Transfusion
715:978-0-230-29319-9
564:10.1136/bmj.h6953
420:(6654): 977–978.
249:blood transfusion
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341:for six months.
50:Bristol, England
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545:"Derrick Tovey"
541:
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289:contact tracing
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251:officer at the
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197:contact tracing
153:Sub-specialties
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26:
17:
12:
11:
5:
891:
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620:(5): 244–247.
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371:(3): 149–152.
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185:West Yorkshire
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90:Known for
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2:
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471:(2): 99–109.
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365:Vox Sanguinis
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330:, to prevent
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25:Derrick Tovey
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19:
793:
789:
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767:. Retrieved
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738:. Retrieved
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328:RhD negative
312:
309:Later career
304:vaccination.
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293:surveillance
270:
267:Early career
261:bacteriology
234:
221:RhD negative
209:
201:surveillance
168:
167:
134:Institutions
119:
111:RhD negative
18:
853:2015 deaths
848:1926 births
769:20 December
740:22 December
322:to prevent
297:vaccination
215:to prevent
205:vaccination
173:pathologist
157:Haematology
105:to prevent
85:Pathologist
64:Nationality
842:Categories
796:(1): 3–6.
509:References
277:Kano Ikeda
259:including
225:Rh disease
126:Profession
82:Occupation
810:1723-2007
634:0141-0768
580:220093569
572:1756-1833
558:: h6953.
485:0958-7578
434:0959-8138
385:0042-9007
257:pathology
129:Physician
72:Education
828:19204744
652:15121819
501:46351120
401:71239311
189:smallpox
181:Bradford
819:2535875
643:1079469
493:1339195
452:2847842
443:1834668
393:6782759
285:malaria
237:Bristol
67:British
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765:. 2003
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213:Anti-D
103:Anti-D
759:(PDF)
576:S2CID
548:(PDF)
497:S2CID
397:S2CID
345:Death
824:PMID
806:ISSN
771:2020
742:2020
710:ISBN
678:ISBN
648:PMID
630:ISSN
568:ISSN
489:PMID
481:ISSN
448:PMID
430:ISSN
389:PMID
381:ISSN
295:and
203:and
56:Died
47:1926
40:Born
814:PMC
798:doi
638:PMC
622:doi
560:doi
556:351
473:doi
438:PMC
422:doi
418:297
373:doi
207:.
179:in
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804:.
792:.
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761:.
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704:.
692:^
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588:^
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