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Sachs further developed his research in the field of transplantation tolerance. In the 1980s Sachs had shown that mixed-chimerism can lead to transplant tolerance in small animal models; these findings were then confirmed in a large animal model during Sachs' tenure at
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Kawai, T; Cosimi, AB; Spitzer, TR; Tolkoff-Rubin, N; Suthanthiran, M; Saidman, SL; Shaffer, J; Preffer, FI; Ding, R; Sharma, V; Fishman, JA; Dey, B; Ko, DS; Hertl, M; Goes, NB; Wong, W; Williams, WW; Colvin, RB; Sykes, M; Sachs, DH (2008).
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in 1973. He was then appointed director of the
Transplantation Biology Section of the Immunology Branch at NCI in 1974, and Chief of the Immunology Branch in 1982.
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As a medical student, Sachs developed an interest in transplantation and joined the laboratory of Drs. Paul
Russell and Henry Winn at the
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Sykes, M (2015). "Introduction of David H. Sachs, MD, recipient of the 2014 Medawar Prize".
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developed the first clinical protocol for the induction of organ transplantation
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In 1991 Sachs returned to Boston, where he was appointed
Professor of Surgery at
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316:"HLA-mismatched renal transplantation without maintenance immunosuppression"
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David Sachs graduated summa cum laude in organic chemistry from
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243:. Based on these observations, Sachs and his colleagues at
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in 1963, and pursued a master's degree equivalent at the
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and for his seminal studies in the fields of transplant
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195:, where he graduated magna cum laude in 1968.
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219:, where his research led to the discovery of
80:First clinical protocol for the induction of
394:Members of the National Academy of Medicine
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215:. He remained in Bethesda and joined the
159:. He is best known for his discovery of
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138:Columbia University Medical Center
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191:in 1964. He then matriculated to
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245:Massachusetts General Hospital
228:Massachusetts General Hospital
205:Massachusetts General Hospital
152:(born January 10, 1942) is an
130:Massachusetts General Hospital
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384:Harvard Medical School alumni
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213:National Institutes of Health
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284:10.1097/TP.0000000000000594
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399:University of Paris alumni
217:National Cancer Institute
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82:transplantation tolerance
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389:Harvard College alumni
369:American immunologists
232:Harvard Medical School
193:Harvard Medical School
134:Harvard Medical School
58:Harvard Medical School
211:'s laboratory at the
16:American immunologist
332:10.1056/NEJMoa071074
251:in the early 2000s.
189:Fulbright Fellowship
185:University of Paris
169:xenotransplantation
120:Xenotransplantation
93:Thomas Starzl Prize
66:University of Paris
209:Christian Anfinsen
150:David Howard Sachs
23:David Howard Sachs
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107:Scientific career
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165:immune tolerance
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221:class II MHC
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161:MHC class II
157:immunologist
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126:Institutions
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77:MHC class II
46:New York, NY
379:1942 births
363:Categories
255:References
35:1942-01-10
249:tolerance
175:Education
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300:40237787
292:25651109
199:Research
154:American
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100:(2014)
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88:Awards
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234:. At
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288:PMID
230:and
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29:Born
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