Bupropion - Knowledge

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Furthermore, systemic administration of bupropion increases selection of the higheffort, high reward option in a PR-choice task in rats (Randall, Lee, Podurgiel, et al. 2014). Bupropion is also effective at rescuing motivational impairments in rodents. Administration of bupropion can rescue deficits in effort-related decision-making induced by pre-treatment with tetrabenazine (Randall, Lee, Nunes, et al. 2014; Nunes, Randall, Hart, et al. 2013) and the proinflammatory cytokine interleukin-6 (Yohn, Arif, et al. 2016). Bupropion has been reported to improve symptoms of apathy in cases of acquired brain injury, major depression (Corcoran et al. 2004) and frontotemporal dementia (Lin et al. 2016). However, several larger placebo-controlled studies suggest only limited effects of bupropion. In a study of 40 patients with schizophrenia, bupropion was found to have no significant effect on apathy or negative symptoms as a whole (Yassini et al. 2014). Furthermore, in a recent RCT of bupropion in HD, apathy was not significantly affected by the drug (Gelderblom et al. 2017). It is not clear whether bupropion lacks clinical efficacy, or whether bupropion as a whole is not affective at treating motivational impairments, or simply not effective in the clinical populations tested.

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decreased efficacy of generic bupropion, which prompted it to ask ConsumerLab.com to test the products in question. The tests showed that "one of a few generic versions of Wellbutrin XL 300 mg, sold as Budeprion XL 300 mg, didn't perform the same as the brand-name pill in the lab." The FDA investigated these complaints and concluded that Budeprion XL is equivalent to Wellbutrin XL in regard to bioavailability of bupropion and its main active metabolite hydroxybupropion. The FDA also said that coincidental natural mood variation is the most likely explanation for the apparent worsening of depression after the switch from Wellbutrin XL to Budeprion XL. On 3 October 2012, however, the FDA reversed this opinion, announcing that "Budeprion XL 300 mg fails to demonstrate therapeutic equivalence to Wellbutrin XL 300 mg." The FDA did not test the bioequivalence of any of the other generic versions of Wellbutrin XL 300 mg, but requested that the four manufacturers submit data on this question to the FDA by March 2013. As of October 2013 the FDA has made determinations on the formulations from some manufacturers not being bioequivalent.

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Bupropion misuse is uncommon. There have been a number of anecdotal and case-study reports of bupropion abuse, but the bulk of evidence indicates that the subjective effects of bupropion when taken orally are markedly different from those of addictive stimulants such as cocaine or amphetamine. However, bupropion, by non-conventional routes of administration like injection or insufflation, has been reported to be misused in the United States and Canada, notably in prisons.

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transporter. Whereas, bupropion is a moderately effective antidepressant when taken alone, thought to act by preventing dopamine and noradrenaline reuptake . Studies in mice have shown that the antidepressant-like effects of bupropion are potentiated by σ-1R agonists, and inhibited by σ-1R antagonists . These findings suggest that the combination of a σ-1R agonist and the dopamine/ noradrenaline reuptake inhibitor will be more effective than either treatment alone.

27362: 42: 1165: 27390: 10649: 8654: 11222: 1712:. When bupropion was one of several kinds of pills taken in an overdose, fever, muscle rigidity, muscle damage, hypertension or hypotension, stupor, coma, and respiratory failure have been reported. While most people recover, some people have died, having had multiple uncontrolled seizures and myocardial infarction. 1803:, with hydroxybupropion responsible for most of the inhibition. Additionally, bupropion and its metabolites may decrease expression of CYP2D6 in the liver. The end effect is a significant slowing of the clearance of other drugs metabolized by this enzyme. For instance, bupropion has been found to increase 1263:

The bupropion treatment course lasts for seven to twelve weeks, with the patient halting the use of tobacco about ten days into the course. After the course, the effectiveness of bupropion for maintaining abstinence from smoking declines over time, from 37% of tobacco abstinence at 3 months to 20% at

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Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. Bupropion treatment is not associated with weight

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In 2009, the FDA issued a health advisory warning that the prescription of bupropion for smoking cessation has been associated with reports about unusual behavior changes, agitation and hostility. Some people, according to the advisory, have become depressed or have had their depression worsen, have

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formulation of alcohol-resistant bupropion called Wellbutrin SR, intended to be taken twice a day (as compared with three times a day for immediate-release Wellbutrin). In 2003, the FDA approved another sustained-release formulation called Wellbutrin XL, intended for once-daily dosing. Wellbutrin SR

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Papakostas GI, Stahl SM, Krishen A, Seifert CA, Tucker VL, Goodale EP, et al. (August 2008). "Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies".

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Following EMA's call for an industry-wide review of medicines for the possible presence of nitrosamines, GlaxoSmithKline paused batch release and distribution of bupropion 150 mg tablets in November 2022. In July 2023, EMA raised the acceptable daily intake of nitrosamines impurities, leading

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may develop. It is associated with higher doses of bupropion; many cases described are at higher than recommended doses. Concurrent antipsychotic medication appears to be protective. In most cases the psychotic symptoms are eliminated by reducing the dose, ceasing treatment or adding antipsychotic

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is a rare but serious adverse effect of bupropion. It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300–450 mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600 mg. For comparison, the

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AXS-05 is a combination of dextromethorphan and bupropion and has been shown to have a rapid (within one week) positive effect in patients with depression. Dextromethorphan, as described above as part of Nuedexta, is a σ-1R agonist, an NMDA antagonist, and has affinity for the serotonin reuptake

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and behavior in children and adolescents, and 1.5-fold increase in the 18–24 age group. For this analysis the FDA combined the results of 295 trials of 11 antidepressants in order to obtain statistically significant results. Considered in isolation, bupropion was not statistically different from

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and fatigue in depressed patients. Bupropion is effective in the treatment of anxious depression and, contrary to common belief, does not exacerbate anxiety in this context. The effectiveness of bupropion for anxious depression is equivalent to that of SSRIs in the case of depression with low or

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While bupropion demonstrates some potential for misuse, this potential is less than of other commonly used stimulants, being limited by features of its pharmacology. Case reports describe misuse of bupropion as producing a "high" similar to cocaine or amphetamine usage but with less intensity.

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at the originally recommended dosage (400–600 mg/day) caused the withdrawal of the drug in 1986. Subsequently, the risk of seizures was found to be highly dose-dependent, and bupropion was re-introduced to the market in 1989 with a lower maximum recommended daily dose of 450 mg/day.

1295:. Systematic reviews of bupropion for the treatment of ADHD in both adults and children note that bupropion may be effective for ADHD but warn that this conclusion has to be interpreted with caution, because clinical trials were of low quality due to small sizes and risk of bias. Similarly to 9371:

In vitro functional studies showed agonist activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol plasma concentration range and overlapped with the observed DAT/NET inhibitory potencies of

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In October 2007, two providers of consumer information on nutritional products and supplements, ConsumerLab.com and The People's Pharmacy, released the results of comparative tests of different brands of bupropion. The People's Pharmacy received multiple reports of increased side effects and

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Bupropion also acts as a dopamine reuptake inhibitor (Dwoskin et al. 2006), and has been used as a treatment for depression as well as a smoking cessation aid (Stahl et al. 2004). Bupropion has been shown to produce a dose-dependent increase in PR breakpoints (Bruijnzeel & Markou 2003).

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The metabolism of bupropion also seems to follow biphasic pharmacokinetics: the redistribution alpha phase with half-life of about 1 hour precedes the metabolism beta phase of about 12-30 hours. This might explain why abuse is unfeasible due to a short "high", as well as support the use of

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The metabolism of bupropion is highly species-dependent. As an example, oral bupropion results in hydroxybupropion levels that are 16-fold higher than those of bupropion itself in humans, whereas in rats, oral bupropion results in levels of bupropion that are 3.4-fold higher than those of

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had thoughts about suicide or dying, or have attempted suicide. This advisory was based on a review of anti-smoking products that identified 75 reports of "suicidal adverse events" for bupropion over ten years. Based on the results of follow-up trials this warning was removed in 2016.

1148:, in 1969. It was first approved for medical use in the United States in 1985. Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. In 2022, it was the 21st most commonly prescribed medication in the United States, with more than 25 3372:(EMA) recommended suspending a number of nationally approved medicines due to misrepresentation of bioequivalence study data by Micro Therapeutic Research Labs in India. The products recommended for suspension included several 300 mg modified-release bupropion tablets. 1355:

Bupropion, when used for treating long term weight gain over a period of 6 to 12 months, results in an average weight loss of 2.7 kg (5.9 lbs) over placebo. This is not much different from the weight loss produced by several other weight-loss medications such as

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The common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. Bupropion has the highest incidence of insomnia of all second-generation antidepressants, apart from

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trials in the meta-analysis. Unpublished trials are more likely to be negative in findings, and other meta-analyses have included unpublished trials. Evidence suggests that the effectiveness of bupropion for depression is similar to that of other antidepressants.

1594:, sometimes severe, is observed in some people taking bupropion, both with and without pre-existing hypertension. Safety of bupropion in people with cardiovascular conditions and its general cardiovascular safety profile remain unclear due to the lack of data. 1380:

Bupropion is not effective in the treatment of cocaine dependence, but it is showing promise in reducing drug use in treating amphetamine-type stimulant use and cravings. Based on studies indicating that bupropion lowers the level of the inflammatory mediator

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mg). The IR formulation is generally administered thrice daily, the SR formulation twice daily, and the XL formulation once daily. The only marketed form of bupropion hydrobromide is Aplenzin, an extended-release oral tablet taken once daily (174, 348,

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symptoms such as depressed mood, irritability, difficulty concentrating, and increased appetite. Initially, bupropion slows the weight gain that often occurs in the first weeks after quitting smoking. With time, however, this effect becomes negligible.

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Protti M, Mandrioli R, Marasca C, Cavalli A, Serretti A, Mercolini L (September 2020). "New-generation, non-SSRI antidepressants: Drug-drug interactions and therapeutic drug monitoring. Part 2: NaSSAs, NRIs, SNDRIs, MASSAs, NDRIs, and others".

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and fatigue. Bupropion, particularly the immediate release formulation, carries a higher risk of seizure than many other antidepressants, hence caution is recommended in patients with a history of seizure disorder. The medication is taken

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Damaj MI, Carroll FI, Eaton JB, Navarro HA, Blough BE, Mirza S, et al. (September 2004). "Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors".

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Cámara-Lemarroy CR, Guzmán-de la Garza FJ, Cordero-Pérez P, Alarcón-Galván G, Ibarra-Hernández JM, Muñoz-Espinosa LE, et al. (2013). "Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion".

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form in the United States and Canada. In 1997, bupropion was approved by the FDA for use as a smoking cessation aid under the name Zyban. In 2006, Wellbutrin XL was similarly approved as a treatment for seasonal affective disorder.

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Hesse LM, He P, Krishnaswamy S, Hao Q, Hogan K, von Moltke LL, et al. (April 2004). "Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes".

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receptor agonists and antagonists, respectively. However, no data on the binding or functional effects of bupropion at the human sigma receptors seem to be available. In any case, bupropion has been reported to bind to rodent

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for depression. One meta-analysis reported a large effect size. However, there were methodological limitations with this meta-analysis, including using a subset of only five trials for the effect size calculation, substantial

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The addition of bupropion to a prescribed SSRI is a common strategy when people do not respond to the SSRI, and it is supported by clinical trials; however, it appears to be inferior to the addition of atypical antipsychotic

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Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, et al. (February 2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis".

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Wilens TE, Hammerness PG, Biederman J, Kwon A, Spencer TJ, Clark S, et al. (February 2005). "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder".

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In 2012, the US Justice Department announced that GlaxoSmithKline had agreed to plead guilty and pay a $ 3 billion fine, in part for promoting the unapproved use of Wellbutrin for weight loss and sexual dysfunction.

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Grandi SM, Shimony A, Eisenberg MJ (December 2013). "Bupropion for smoking cessation in patients hospitalized with cardiovascular disease: a systematic review and meta-analysis of randomized controlled trials".

10739: 1327:. A range of studies indicate that bupropion not only produces fewer sexual side effects than other antidepressants but can actually help to alleviate sexual dysfunction including sexual dysfunction induced by 10973: 1756:. The expected result is the increase of bupropion and decrease of hydroxybupropion blood concentration. The reverse effect (decrease of bupropion and increase of hydroxybupropion) can be expected with CYP2B6 6128:"Primary Care-Relevant Interventions for Tobacco and Nicotine Use Prevention and Cessation in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force" 1278:

In children and adolescents, the use of bupropion for smoking cessation does not appear to offer any significant benefits. The evidence for its use to aid smoking cessation in pregnant women is insufficient.

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Akbar D, Rhee TG, Ceban F, Ho R, Teopiz KM, Cao B, et al. (October 2023). "Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials".

5304:"Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trials" 10875: 9223:

Ferris RM, Russell A, Tang FL, Topham PA (1991). "Labeling in vivo of sigma receptors in mouse brain with -(+)-SKF 10,047: Effects of phencyclidine, (+)- and (−)-N-allylnormetazocine, and other drugs".

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Majeed A, Xiong J, Teopiz KM, Ng J, Ho R, Rosenblat JD, et al. (March 2021). "Efficacy of dextromethorphan for the treatment of depression: a systematic review of preclinical and clinical trials".

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at therapeutic doses is thought to occupy greater than 50% of DAT sites. In accordance with its low DAT occupancy, no measurable dopamine release in the human brain was detected with bupropion (one 150

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Hart XM, Spangemacher M, Defert J, Uchida H, Gründer G (April 2024). "Update Lessons from PET Imaging Part II: A Systematic Critical Review on Therapeutic Plasma Concentrations of Antidepressants".

5604: 10899:"Products for which the marketing authorisations are recommended for suspension and marketing authorisation applications which do not satisfy the criteria for authorisation as adopted by the CHMP" 10626: 8318:

Kharasch ED, Neiner A, Kraus K, Blood J, Stevens A, Miller JP, et al. (November 2020). "Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults".

14481: 5170:"The comparative evidence basis for the efficacy of second-generation antidepressants in the treatment of depression in the US: A Bayesian meta-analysis of Food and Drug Administration reviews" 2799:, is also characterized by inhibition of norepinephrine and dopamine reuptake and nicotinic inhibition (see the chart on the right). Bupropion has no meaningful direct activity at a variety of 3062:

may differ by as much as 7.5 times (with a half-life of 15–25 hours). Based on this, some researchers have advocated monitoring of the blood level of bupropion and hydroxybupropion.

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stating that antidepressants may increase the risk of suicide in people younger than 25. This warning is based on a statistical analysis conducted by the FDA which found a 2-fold increase in

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Overall, six months after the therapy, bupropion increases the likelihood of quitting smoking by approximately 1.6 fold as compared to placebo. In this respect, bupropion is as effective as

1022:(SSRI) antidepressant. Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, it is not associated with weight gain and 16541: 10675: 5366:"Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis" 3054:

The metabolism of bupropion is highly variable: the effective doses of bupropion received by persons who ingest the same amount of the drug may differ by as much as 5.5 times (with a

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Bupropion raises blood pressure in some people. One study showed an average rise of 6 mm Hg in systolic blood pressure in 10% of patients. The prescribing information notes that

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Vyas R, Nesheiwat Z, Ruzieh M, Ammari Z, Al-Sarie M, Grubb B (August 2020). "Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience".

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in effect sizes between the selected trials—which led the authors to state that their findings in this area should be interpreted with "extreme caution"—and general lack of inclusion of

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Tafseer S, Gupta R, Ahmad R, Jain S, Bhatia MS, Gupta LK (January 2021). "Bupropion monotherapy alters neurotrophic and inflammatory markers in patients of major depressive disorder".

11080: 6326:"Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis" 5556:"Significant Treatment Effect of Bupropion in Patients With Bipolar Disorder but Similar Phase-Shifting Rate as Other Antidepressants: A Meta-Analysis Following the PRISMA Guidelines" 9310:

Simmler LD, Buchy D, Chaboz S, Hoener MC, Liechti ME (April 2016). "In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1".

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incidence of unprovoked seizure in the general population is 0.07–0.09%, and the risk of seizure for a variety of other antidepressants is generally 0–0.5% at the recommended doses.

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hydroxybupropion. The species-dependent metabolism of bupropion is thought to be involved in species differences in its pharmacodynamic effects. For example, bupropion produces

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Costa R, Oliveira NG, Dinis-Oliveira RJ (August 2019). "Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects".

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Costa R, Oliveira NG, Dinis-Oliveira RJ (August 2019). "Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects".

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Gursahani H, Jolas T, Martin M, Cotier S, Hughes S, Macfadden W, et al. (2023). "Preclinical Pharmacology of Solriamfetol: Potential Mechanisms for Wake Promotion".

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Kumar S, Kodela S, Detweiler JG, Kim KY, Detweiler MB (November–December 2011). "Bupropion-induced psychosis: folklore or a fact? A systematic review of the literature".

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Musso DL, Mehta NB, Soroko FE, Ferris RM, Hollingsworth EB, Kenney BT (1993). "Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion".

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and clopidogrel, both potent CYP2B6 inhibitors, have been found to considerably increase bupropion levels as well as decrease levels of its metabolite hydroxybupropion.

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Ketter TA, Jenkins JB, Schroeder DH, Pazzaglia PJ, Marangell LB, George MS, et al. (October 1995). "Carbamazepine but not valproate induces bupropion metabolism".

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gain; on the contrary, the majority of studies observed significant weight loss in bupropion-treated participants. Bupropion treatment also is not associated with the

10965: 2989:. As for the relative bioavailability of the formulations, XL formulation has lower bioavailability (68%) compared to SR formulation and immediate release bupropion. 24107: 23767: 16534: 16339: 3692: 9044:

Rau KS, Birdsall E, Hanson JE, Johnson-Davis KL, Carroll FI, Wilkins DG, et al. (November 2005). "Bupropion increases striatal vesicular monoamine transport".

6087:"Interventions for Tobacco Cessation in Adults, Including Pregnant Persons: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force" 27480: 21275: 9372:

solriamfetol in vitro. TAAR1 agonist activity was unique to solriamfetol; neither the WPA modafinil nor the DAT/NET inhibitor bupropion had TAAR1 agonist activity.

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Tatsumi M, Groshan K, Blakely RD, Richelson E (December 1997). "Pharmacological profile of antidepressants and related compounds at human monoamine transporters".

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than a dopamine reuptake inhibitor. Accordingly, the clinical effects of bupropion are more consistent with noradrenergic activity than with dopaminergic actions.

26124: 4499:"Morbidity and Mortality Associated With Medications Used in the Treatment of Depression: An Analysis of Cases Reported to U.S. Poison Control Centers, 2000–2014" 3687:[Collegiate Board Resolution No. 784 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). 1347:

of bupropion for sexual desire disorder in women reported that although data were limited, bupropion appeared to be dose-dependently effective for the condition.

17653: 14173: 11676: 9699:"A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice" 1708:. For significant overdoses, seizures have been reported in about a third of all cases; other serious effects include hallucinations, loss of consciousness, and 26119: 8873:

Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding".

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Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding".

27515: 20542: 16744: 16399: 14516: 10867: 4611:"Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants" 1854:

have also been reported. However, in a notable exception, bupropion does not seem to affect the concentrations of CYP2D6 substrates fluoxetine and paroxetine.

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Wander TJ, Nelson A, Okazaki H, Richelson E (December 1986). "Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro".

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Brimson JM, Brimson S, Chomchoei C, Tencomnao T (October 2020). "Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain".

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in the pharmacology of bupropion, and suggest that other actions may be responsible for its therapeutic effects. No data are available on occupancy of the

16527: 10408: 5415:"Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials" 9146:

Dhir A, Kulkarni SK (August 2008). "Possible involvement of sigma-1 receptors in the anti-immobility action of bupropion, a dopamine reuptake inhibitor".

8689:"BindingDB BDBM50048392 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::BUPROPION HYDROCHLORIDE::CHEMBL894::US9944618, Compound ID No. 176" 23278: 8027: 7237:

Lyonga Ngonge A, Nyange C, Ghali JK (February 2024). "Novel pharmacotherapeutic options for the treatment of postural orthostatic tachycardia syndrome".

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In April 2008, the FDA approved a formulation of bupropion as a hydrobromide salt instead of a hydrochloride salt, to be sold under the name Aplenzin by

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Baribeau D, Araki KF (May–June 2013). "Intravenous bupropion: a previously undocumented method of abuse of a commonly prescribed antidepressant agent".

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Spina E, Santoro V, D'Arrigo C (July 2008). "Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update".

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of bupropion in the treatment of depression and for other indications is unclear. However, it is thought to be related to the fact that bupropion is a

7778:"Antidepressants and suicidality in adults: statistical evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)" 359: 11284: 4041:(2000). "International nonproprietary names for pharmaceutical substances (INN) : proposed international nonproprietary names : list 83". 1826:

increased approximately 35-fold when it was administered to people being treated with 300 mg/day bupropion. When people on bupropion are given

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Lile JA, Nader MA (2003). "The abuse liability and therapeutic potential of drugs evaluated for cocaine addiction as predicted by animal models".

7522:"Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort" 6218:"Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents" 4649: 4543:"A Systematic Review and Meta-Analysis Considering the Risk for Congenital Heart Defects of Antidepressant Classes and Individual Antidepressants" 27299: 22421: 15596: 11643: 10998:

Naglich AC, Brown ES, Adinoff B (2019). "Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential".

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Naglich AC, Brown ES, Adinoff B (2019). "Systematic review of preclinical, clinical, and post-marketing evidence of bupropion misuse potential".

1393:, and other autoimmune conditions, but very little clinical evidence is available. Bupropion is not effective in treating chronic low back pain. 9854:

Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI (2014). "Bupropion and bupropion analogs as treatments for CNS disorders".

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Karimollah A, Hemmatpur A, Vahid T (August 2021). "Revisiting bupropion anti-inflammatory action: involvement of the TLR2/TLR4 and JAK2/STAT3".

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Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release

8234:

Feinberg SS (November 2004). "Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication".

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Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI (2014). "Bupropion and bupropion analogs as treatments for CNS disorders".

922: 24366: 22559: 19963: 17046: 12571: 10836: 2755: 1106: 291: 8017:"Highlight os Prescribing Information: CONTRAVE (naltrexone hydrochloride and bupropion hydrochloride) extended-release tablets, for oral use" 3414:

Brand names include Wellbutrin, Aplenzin, Budeprion, Buproban, Forfivo, Voxra, Zyban, Bupron, Bupisure, Bupep, Smoquite, Elontril, and Buxon.

23920: 23875: 23487: 22106: 22061: 21769: 18309: 16824: 13719: 7941:

Jefferson JW, Pradko JF, Muir KT (November 2005). "Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations".

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The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)

1214:: 15% of participants on bupropion experienced a major depressive episode vs. 27% of those on placebo. Bupropion also improves depression in 183: 10762:"The smoking cessation aids varenicline (marketed as Chantix) and bupropion (marketed as Zyban and generics) suicidal ideation and behavior" 10589: 7455: 6905:

Cao DN, Shi JJ, Hao W, Wu N, Li J (June 2016). "Advances and challenges in pharmacotherapeutics for amphetamine-type stimulants addiction".

6373:

Ng QX (March 2017). "A Systematic Review of the Use of Bupropion for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents".

3312:

plasma bupropion levels with bupropion IR 100 mg t.i.d. (3x/day), bupropion SR 150 mg b.i.d. (2x/day), and bupropion XL 300 mg q.d. (1x/day)

24471: 24386: 23812: 23049: 23024: 22599: 21363: 20117: 19948: 18771: 18053: 17484: 16794: 16461: 16003: 15998: 15279: 15274: 15093: 13505: 13417: 12458: 11709: 11077: 7174: 3376:

GlaxoSmithKline to announce that distribution of bupropion 150 mg tablets would resume "across the EU and Europe" by the end of 2023.

2862:(NET) by bupropion and its metabolites. However, due to the increased exposure of hydroxybupropion over bupropion itself, which has higher 936: 10813: 1291:(ADHD) is not an approved indication of bupropion, and it is not mentioned in the current (2019) guideline on the ADHD treatment from the 24843: 24476: 24401: 24351: 24022: 23757: 23735: 23710: 23700: 23545: 23029: 23019: 23009: 22544: 22529: 22519: 22417: 22162: 22137: 22091: 21698: 21438: 21358: 20697: 20102: 20068: 18716: 18635: 18244: 17963: 17646: 17179: 16619: 16614: 14166: 4814: 2767: 26154: 26149: 10934: 10530: 8803:

Cusack B, Nelson A, Richelson E (May 1994). "Binding of antidepressants to human brain receptors: focus on newer generation compounds".

8271:"Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial" 6652:"Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review" 4937: 3953: 25202: 25152: 24097: 24047: 23989: 23984: 22953: 22524: 22157: 22152: 21979: 21322: 20598: 19907: 18761: 18751: 18254: 16749: 15782: 2705:(1) Values are in nanomolar (nM) units. The smaller the value, the more avidly the drug binds to or affects the site. (2) Affinities (K 26169: 26144: 10362: 3026: 2970:

After oral administration, bupropion is rapidly and completely absorbed reaching the peak blood plasma concentration after 1.5 hours (

24888: 24883: 24878: 24873: 24863: 24858: 24853: 24848: 24838: 24828: 24818: 24798: 24788: 24783: 24778: 24593: 24533: 24311: 24306: 24301: 24296: 24077: 23890: 23660: 23039: 23034: 22456: 17918: 17913: 17908: 17026: 16969: 16934: 16909: 16814: 16639: 16634: 16379: 16120: 14511: 14506: 13997: 11460: 10534: 9520:

Yetkin D, Yılmaz İA, Ayaz F (September 2023). "Anti-inflammatory activity of bupropion through immunomodulation of the macrophages".

7420:"Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: a meta-analysis" 2788:

that are present in the blood plasma at comparable or much higher levels. In fact, bupropion could accurately be conceptualized as a

1432: 26164: 26159: 26139: 26134: 8467:

Bondarev ML, Bondareva TS, Young R, Glennon RA (August 2003). "Behavioral and biochemical investigations of bupropion metabolites".

3078:

effects in rodents, whereas oral bupropion at therapeutic doses seems to have much less or no potential for such effects in humans.

1665:(about 80% increase). The evidence is insufficient to determine whether bupropion is associated with suicides or suicidal behavior. 27470: 24758: 24753: 24703: 24326: 24321: 24316: 24207: 24202: 24082: 23787: 23685: 23680: 23665: 23600: 23595: 23342: 23234: 21013: 20397: 19554: 17051: 16504: 13413: 10599: 10336: 4349: 3654: 3304: 1288: 1235:

moderate anxiety, whereas SSRIs show a modest effectiveness advantage in terms of response rates for depression with high anxiety.

26767: 10310: 27292: 24723: 24613: 24603: 24598: 24291: 23782: 23271: 23194: 21025: 20409: 19566: 18164: 17324: 11504: 8741:

Richelson E, Nelson A (July 1984). "Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro".

3264: 1967: 1804: 1677: 9936:

Welch RM, Lai AA, Schroeder DH (March 1987). "Pharmacological significance of the species differences in bupropion metabolism".

6826: 4841:

Gautam M, Patel S, Zarkowski P (January 2022). "Practice patterns of bupropion co-prescription with antipsychotic medications".

3888: 3855: 3825: 3786: 25172: 24276: 24271: 23221: 23212: 17639: 14501: 14159: 12950: 1227: 1019: 10504: 7352: 6267:"Pharmacologic treatment of attention deficit hyperactivity disorder in adults: A systematic review and network meta-analysis" 25697: 23203: 13677: 12515: 11315: 11260: 10464: 10109: 9871: 9759: 8054:"Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers" 7865: 7322: 5989:"Diminishing benefit of smoking cessation medications during the first year: a meta-analysis of randomized controlled trials" 5042: 4931: 4800: 4698: 4079: 2901: 1784:. Indeed, carbamazepine decreases exposure to bupropion by 90% and increases exposure to hydroxybupropion by 94%. Ritonavir, 1612:

have been reported for bupropion. It is considered to be one of several antidepressants with greater risk of hepatotoxicity.

1153: 11239:Эфедрон (меткатинон) и его производные, за исключением производных, включенных в качестве самостоятельных позиций в перечень 4419:

Voican CS, Corruble E, Naveau S, Perlemuter G (April 2014). "Antidepressant-induced liver injury: a review for clinicians".

3463: 3328:(FDA) as an antidepressant on 30 December 1985, and marketed under the name Wellbutrin. However, a significant incidence of 19762: 12658: 10582: 9726: 8688: 4895: 3406:. In Australia, France, and the UK, smoking cessation is the only licensed use of bupropion, and no generics are marketed. 2866:

for the NET than the DAT, bupropion's overall pharmacological profile in humans may end up making it effectively more of a

2854:, though it is unknown if this effect is more pronounced than other DRIs. These findings raise questions about the role of 1657:

Bupropion prescribed for smoking cessation results in 25% increase of the risk of psychiatric side effects, in particular,

8372:"Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation" 3684: 2977:). Sustained release (SR) and extended release (XL) formulations have been designed to slow down absorption resulting in t 27460: 26909: 26682: 26539: 23225: 20973: 20846: 19500: 19360: 16488: 11742: 6793:"Drug Approval Package: Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets NDA #200063" 11419: 11402: 4542: 2678: 25069: 23264: 14854: 12564: 11610: 10150: 10133: 6460:

Serretti A, Chiesa A (June 2009). "Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis".

4224:

Dhillon S, Yang LP, Curran MP (2008). "Bupropion: a review of its use in the management of major depressive disorder".

3680: 1545: 1397: 7477:

Telang S, Walton C, Olten B, Bloch MH (August 2018). "Meta-analysis: Second generation antidepressants and headache".

27410: 27306: 25197: 25187: 25167: 20939: 20931: 20864: 20352: 20344: 19453: 19445: 19378: 16561: 12943: 9565:"Bupropion for interferon-alpha-induced depression in patients with hepatitis C viral infection: an open-label study" 2929: 2867: 2851: 2824: 2123: 2093: 1577: 1336: 981: 956: 234: 123: 113: 10776: 9389:"Peripheral inflammatory effects of different interventions for treatment-resistant depression: A systematic review" 7605:

Pisani F, Oteri G, Costa C, Di Raimondo G, Di Perri R (2002). "Effects of psychotropic drugs on seizure threshold".

6693:"The Role of Bupropion in the Treatment of Women with Sexual Desire Disorder: A Systematic Review and Meta-Analysis" 27485: 27313: 25707: 25525: 25192: 25177: 25162: 24945: 20927: 20340: 19441: 16550: 16303: 13694: 12532: 10271:

Perrine DM, Ross JT, Nervi SJ, Zimmerman RH (2000). "A Short, One-Pot Synthesis of Bupropion (Zyban, Wellbutrin)".

2763: 2656: 2630: 2600: 2570: 2540: 2510: 2484: 1676:

Although studies are lacking, a handful of case reports suggest that abrupt discontinuation of bupropion may cause

4994: 27495: 27330: 27239: 25820: 25520: 25470: 25182: 23367: 21094: 20989: 20935: 20423: 20348: 19637: 19516: 19449: 18513: 13363: 10557: 9261:"Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications" 6792: 4894:. United States National Library of Medicine – National Center for Biotechnology Information. 28 July 2018. 4297:

Steinert T, Fröscher W (July 2018). "Epileptic Seizures Under Antidepressive Drug Treatment: Systematic Review".

3918: 3309: 1757: 1118: 601: 331: 215: 10396: 5839:

Hajizadeh A, Howes S, Theodoulou A, Klemperer E, Hartmann-Boyce J, Livingstone-Banks J, et al. (May 2023).

1815:

by 5.1-fold, while decreasing the exposure to its main metabolite by 1.5-fold. As another example, the ratio of

27475: 27285: 26260: 26129: 26114: 26109: 25692: 23407: 23243: 16984: 16580: 16508: 1292: 8016: 5505:

Gartlehner G, Nussbaumer-Streit B, Gaynes BN, Forneris CA, Morgan LC, Greenblatt A, et al. (March 2019).

1556:(MAOIs). The label recommends that caution should be exercised when treating people with liver damage, severe 692: 27510: 26647: 26104: 26099: 25687: 25682: 25447: 24526: 21017: 20401: 19558: 15564: 14005: 12557: 11453: 11226: 10430: 3685:"RDC Nº 784 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" 2842:(PET) studies is approximately 20%, with a mean occupancy range of about 14 to 26%. For comparison, the NDRI 2759: 1110: 10697: 7724:

Herstowska M, Komorowska O, Cubała WJ, Jakuszkowiak-Wojten K, Gałuszko-Węgielnik M, Landowski J (May 2014).

3746: 3714: 1626:

Bupropion use by mothers in the first trimester of pregnancy is associated with 23% increase of the odds in

1210:

Over the autumn and winter months, bupropion prevents development of depression in those who have recurring

26061: 25064: 24501: 23185: 22381: 21707: 20993: 19520: 17610: 16484: 14201: 14182: 10809: 10735: 10732:"Public Health Advisory: FDA requires new boxed warnings for the smoking cessation drugs Chantix and Zyban" 10703: 10630: 10594: 10473: 10436: 10402: 7781: 6827:"Contrave Extended-Release – naltrexone hydrochloride and bupropion hydrochloride tablet, extended release" 6798: 5003: 3688: 3325: 2855: 2839: 1634: 1369: 1268: 743: 5616: 27430: 26827: 26534: 26041: 26036: 25081: 24192: 21673: 21086: 20977: 20622: 19973: 19504: 18766: 18472: 17968: 16674: 15848: 15124: 12115: 12048: 11276: 8716: 7070:"Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review" 5168:

Monden R, Roest AM, van Ravenzwaaij D, Wagenmakers EJ, Morey R, Wardenaar KJ, et al. (August 2018).

3988:"Chiral Plasma Pharmacokinetics and Urinary Excretion of Bupropion and Metabolites in Healthy Volunteers" 3626:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)" 2951: 2414: 2388: 1885: 1553: 1382: 1211: 831: 7785: 6036:

Livingstone-Banks J, Norris E, Hartmann-Boyce J, West R, Jarvis M, Chubb E, et al. (October 2019).

27500: 27450: 27415: 27380: 25672: 24550: 24542: 23054: 22629: 21892: 21468: 21060: 20717: 20122: 19611: 16998: 16724: 16594: 14843: 14355: 13955: 13421: 12696: 11878: 11786: 10868:"EMA recommends suspension of medicines due to unreliable studies from Micro Therapeutic Research Labs" 8665:. University of North Carolina at Chapel Hill and the United States National Institute of Mental Health 6505:"A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor" 4610: 3099: 2917: 2859: 2286: 2047: 1509: 1448: 1386: 1134: 5197: 3221:

There have been reported cases of false-positive urine amphetamine tests in persons taking bupropion.

1471:

salt. The available forms of bupropion hydrochloride include IR (instant-release) tablets (50, 75, 100

1303:

for ADHD, and several weeks of treatment are required for therapeutic effects. This is in contrast to

820: 27004: 25985: 25815: 24137: 23845: 13929: 13425: 12865: 11890: 10224:"Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay" 6324:

Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S, et al. (September 2018).

5944:

Mooney ME, Sofuoglu M (July 2006). "Bupropion for the treatment of nicotine withdrawal and craving".

5169: 5089: 4270:

Baldwin DS, Papakostas GI (2006). "Symptoms of fatigue and sleepiness in major depressive disorder".

4038: 3625: 3369: 3238: 2804: 1861:

threshold, and therefore can potentially interact with other medications that also lower it, such as

1697: 1007: 25012: 11055: 3578:"15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL" 2954:(TNFα). The catecholaminergic actions of bupropion may be involved in its immunomodulatory effects. 1492:

mg of bupropion hydrochloride). In addition to single-drug formulations, bupropion is formulated in

27425: 27341: 27234: 27008: 26891: 26787: 26777: 26677: 24519: 23076: 22643: 21935: 21721: 21513: 20152: 17584: 13517: 13488: 13288: 11446: 11401:

Emmanuel NP, Brawman-Mintzer O, Morton WA, Book SW, Johnson MR, Lorberbaum JP, et al. (2000).

10590:"Review of therapeutic equivalence: generic bupropion XL 300 mg and Wellbutrin XL 300 mg" 9811:

Preskorn SH (1991). "Should bupropion dosage be adjusted based upon therapeutic drug monitoring?".

9094:"Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders" 3005: 2808: 2770:. Pharmacological actions of bupropion, to a substantial degree, are due to its active metabolites 1912: 1866: 1264:

one year. It is unclear whether extending bupropion treatment helps to prevent relapse of smoking.

847: 11366:

Emmanuel NP, Lydiard RB, Ballenger JC (August 1991). "Treatment of social phobia with bupropion".

8551:"Bupropion Inhibits Serotonin Type 3AB Heteromeric Channels at Clinically Relevant Concentrations" 7119:

Urquhart DM, Hoving JL, Assendelft WW, Roland M, van Tulder MW (January 2008). Urquhart DM (ed.).

6167:

Claire R, Chamberlain C, Davey MA, Cooper SE, Berlin I, Leonardi-Bee J, et al. (March 2020).

27465: 26772: 26051: 26010: 25734: 25602: 25597: 25587: 25515: 25505: 25259: 25249: 25232: 25091: 22823: 22389: 22226: 21711: 21133: 20452: 20301: 19666: 18841: 18526: 18067: 16714: 16321: 14084: 13682: 13528: 12966: 12520: 6976:

Mikocka-Walus AA, Turnbull DA, Moulding NT, Wilson IG, Andrews JM, Holtmann GJ (September 2006).

6650:

Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, et al. (January 2017).

3435: 3423: 3337: 3091: 2921: 2863: 2800: 1627: 1130: 1122: 1099: 1003: 271: 137: 8600:"The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors" 5248:

Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018).

27058: 26847: 26817: 26211: 26179: 26088: 25727: 25495: 25132: 25041: 25033: 25025: 25017: 24346: 24147: 23855: 23397: 22852: 22819: 22461: 22377: 22222: 21779: 21703: 21649: 21212: 21149: 21125: 20892: 20514: 20476: 20444: 20419: 19767: 19682: 19658: 19406: 19195: 19050: 18857: 18853: 18833: 18534: 18518: 18146: 18083: 18063: 17752: 17003: 16500: 16496: 15903: 15179: 14609: 14562: 13154: 12805: 12355: 11826: 11050: 3954:"Zyban 150 mg prolonged release film-coated tablets – Summary of Product Characteristics (SPC)" 3075: 1424:. However, only limited benefits of bupropion in the treatment of apathy have been observed in 1417: 439: 16519: 10099: 8093:

Schmid Y, Rickli A, Schaffner A, Duthaler U, Grouzmann E, Hysek CM, et al. (April 2015).

4788: 27435: 27335: 26762: 26046: 25990: 25863: 25848: 25837: 25490: 25227: 25207: 23752: 23094: 22665: 22385: 21925: 21737: 21655: 21527: 21145: 21129: 20888: 20884: 20740: 20472: 20460: 20448: 20162: 19678: 19662: 19402: 19398: 18837: 18522: 17569: 17518: 17479: 15621: 15553: 15027: 14329: 11796: 5605:"Antidepressant-Associated Sexual Dysfunction: A Potentially Avoidable Therapeutic Challenge" 4921: 3185: 3095: 3045: 3022: 2782: 2337: 2070: 1948: 1830:, about 30% increase of exposure to both drugs is observed, with enhanced mood but decreased 1609: 1331:

antidepressants. There have also been small studies suggesting that bupropion or a bupropion/

1126: 800: 683: 499: 9611: 6769: 6752: 2947:. One such mechanism underlying these effects may be reduced levels of the pro-inflammatory 27455: 26687: 26367: 26226: 26221: 25878: 25868: 25858: 25722: 25510: 25462: 25407: 25397: 25147: 23575: 17564: 17429: 17409: 17249: 17194: 17109: 16899: 16492: 16364: 15893: 15437: 15169: 14599: 14578: 14190: 13258: 12581: 12475: 12390: 10374: 10309:. U.S. Food and Drug Administration Center for Drug Evaluation and Research. Archived from 10280: 8995:

Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, et al. (March 2010).

7520:

Kittle J, Lopes RD, Huang M, Marquess ML, Wilson MD, Ascher J, et al. (October 2017).

6278: 5315: 4609:

Eap CB, Gründer G, Baumann P, Ansermot N, Conca A, Corruble E, et al. (October 2021).

3055: 2831: 2792:

of these metabolites. Overall action of these metabolites, and particularly one enantiomer

2235: 2024: 1777: 1728:, drug interactions with CYP2B6 inhibitors are possible: this includes such medications as 1497: 1444: 1365: 1275:. Combining bupropion and nicotine replacement therapy does not improve the quitting rate. 1252: 752: 635: 512: 11175:

Stassinos GL, Klein-Schwartz W (2016). "Bupropion "Abuse" Reported to US Poison Centers".

8095:"Interactions between bupropion and 3,4-methylenedioxymethamphetamine in healthy subjects" 4793:

The American Psychiatric Association Publishing Textbook of Mood Disorders, Second Edition

8: 27505: 27445: 27420: 26732: 26529: 26275: 26078: 26025: 25677: 25592: 25582: 25530: 25500: 25436: 25323: 25254: 25244: 25127: 22827: 22393: 22333: 22021: 21637: 20858: 20838: 20456: 20366: 19372: 19352: 19199: 18849: 18530: 18075: 17579: 17464: 17449: 17384: 16979: 16178: 16023: 15888: 15616: 15473: 15299: 15164: 14819: 14594: 13538: 13324: 13203: 13175: 13005: 12594: 12301: 12241: 11097:

Phillips D (February 2012). "Wellbutrin®: misuse and abuse by incarcerated individuals".

8370:

Lukas RJ, Muresan AZ, Damaj MI, Blough BE, Huang X, Navarro HA, et al. (June 2010).

8269:

Kharasch ED, Neiner A, Kraus K, Blood J, Stevens A, Schweiger J, et al. (May 2019).

7726:"Severe skin complications in patients treated with antidepressants: a literature review" 7029:"Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD" 3234: 3038: 2971: 2775: 2751: 1936: 1889: 1785: 1620: 1454: 1218:, with the efficacy and risk of affective switch being similar to other antidepressants. 1186: 1032: 732: 626: 491: 278: 26999: 10802:"Safety Alerts for Human Medical Products – Chantix (varenicline) and Zyban (bupropion)" 10332: 10284: 6413:"An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adults" 6282: 6216:

Wolraich ML, Hagan JF, Allan C, Chan E, Davison D, Earls M, et al. (October 2019).

5865: 5840: 5507:"Second-generation antidepressants for preventing seasonal affective disorder in adults" 5319: 4360: 4120:"Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant" 851: 25888: 25883: 24985: 24410: 23437: 23411: 23290: 23158: 22716: 22296: 21988: 21153: 20546: 20480: 19686: 17665: 17499: 17439: 17349: 17274: 17169: 17154: 17144: 16553: 16263: 14289: 13933: 13742: 13711: 13623: 13269: 13198: 13085: 12874: 12768: 12728: 12690: 12682: 12649: 12628: 11492: 11488: 11200: 11122: 11023: 10248: 10223: 10163: 9863: 9676: 9626: 9589: 9564: 9545: 9502: 9454: 9437: 9418: 9287: 9260: 9118: 9093: 9069: 9021: 8996: 8624: 8599: 8575: 8550: 8531: 8449: 8396: 8371: 8343: 8295: 8270: 8181: 8124: 7907: 7882: 7833: 7808: 7750: 7725: 7674: 7649: 7630: 7546: 7521: 7502: 7447: 7400: 7145: 7120: 7004: 6977: 6882: 6857: 6751:

Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR, et al. (April 2005).

6730: 6717: 6692: 6627: 6602: 6578: 6553: 6485: 6437: 6412: 6350: 6325: 6301: 6266: 6242: 6217: 6193: 6168: 6062: 6037: 6013: 5988: 5969: 5916: 5889: 5813: 5786: 5762: 5735: 5716: 5667: 5580: 5555: 5531: 5506: 5466:"Selective publication of antidepressant trials and its influence on apparent efficacy" 5441: 5414: 5390: 5365: 5338: 5303: 5274: 5249: 5210: 5143: 4866: 4759: 4734: 4690: 4641: 4570: 4472: 4322: 4249: 4196: 4171: 4144: 4119: 4012: 3987: 3602: 3577: 3553: 2820: 2816: 1549: 1324: 1145: 1071: 245: 12935: 12549: 10966:"Bupropion to be made available in the UK again from December 2023, says manufacturer" 10627:"Budeprion XL 300 mg not therapeutically equivalent to Wellbutrin XL 300 mg" 8851: 8480: 8212: 6708: 6554:"Women's sexual dysfunction associated with psychiatric disorders and their treatment" 6529: 6504: 6341: 6265:

Elliott J, Johnston A, Husereau D, Kelly SE, Eagles C, Charach A, et al. (2020).

6085:

Patnode CD, Henderson JT, Coppola EL, Melnikow J, Durbin S, Thomas RG (January 2021).

5265: 5131: 2019:(μM) in human cells, unless noted otherwise (Lesser values indicate greater potency.) 1688:

Bupropion is considered moderately dangerous in overdose. According to an analysis of

27490: 27091: 26640: 26216: 25963: 25953: 25923: 25853: 25545: 25288: 24960: 22945: 22835: 22337: 21582: 21141: 20957: 20808: 20468: 20378: 20370: 20254: 20076: 19674: 19524: 19312: 19153: 19099: 18733: 18458: 18450: 18185: 18091: 17889: 17873: 17726: 17589: 17309: 17189: 17069: 16254: 14992: 14699: 14274: 13882: 13597: 13075: 13070: 12844: 12811: 12759: 12704: 12677: 12492: 12394: 11913: 11424: 11383: 11379: 11348: 11311: 11256: 11192: 11157: 11114: 11015: 10896: 10865: 10253: 10204: 10155: 10105: 10023: 9988: 9953: 9915: 9877: 9867: 9820: 9793: 9789: 9755: 9718: 9680: 9668: 9630: 9594: 9549: 9537: 9506: 9494: 9459: 9422: 9410: 9362: 9327: 9292: 9241: 9201: 9163: 9159: 9123: 9061: 9057: 9026: 9012: 8977: 8926: 8890: 8855: 8820: 8785: 8781: 8750: 8629: 8615: 8580: 8523: 8484: 8441: 8401: 8347: 8335: 8300: 8251: 8216: 8185: 8173: 8116: 8075: 7993: 7989: 7958: 7912: 7861: 7838: 7755: 7706: 7679: 7622: 7618: 7587: 7551: 7494: 7439: 7404: 7392: 7289: 7254: 7219: 7215: 7150: 7101: 7050: 7009: 6958: 6922: 6887: 6774: 6734: 6722: 6673: 6632: 6583: 6534: 6477: 6442: 6390: 6355: 6306: 6247: 6198: 6149: 6108: 6067: 6018: 5961: 5921: 5890:"Effectiveness of smoking cessation therapies: a systematic review and meta-analysis" 5870: 5818: 5767: 5720: 5708: 5659: 5585: 5536: 5487: 5446: 5395: 5343: 5279: 5202: 5135: 4966:"United States Patent 3,819,706: Meta-chloro substituted α-butylamino-propiophenones" 4927: 4870: 4858: 4806: 4796: 4764: 4704: 4694: 4645: 4633: 4574: 4562: 4520: 4476: 4436: 4398: 4314: 4279: 4253: 4241: 4237: 4201: 4149: 4075: 4017: 3778: 3607: 3557: 3545: 3249: 3203: 3161: 3157: 2986: 2936: 2812: 1811:, a CYP2D6 substrate, by 5-fold. Bupropion has also been found to increase levels of 1650: 1565: 1533: 1457: 1340: 1011: 383: 371: 207: 26782: 17088: 17084: 17012: 11204: 11027: 10167: 9109: 9073: 8453: 8128: 7954: 7634: 7506: 7451: 5973: 5671: 5364:

Stone MB, Yaseen ZS, Miller BJ, Richardville K, Kalaria SN, Kirsch I (August 2022).

5147: 4326: 3779:"Zyban 150 mg prolonged release tablets – Summary of Product Characteristics (SmPC)" 27365: 27190: 27078: 25958: 25938: 25778: 25442: 25417: 25361: 25001: 23979: 23945: 23442: 23422: 23298: 21847: 21669: 21082: 20321: 20305: 20291: 20194: 20018: 19629: 17459: 17269: 17164: 17036: 16599: 16575: 16359: 16214: 15586: 14982: 14679: 14619: 14436: 14350: 13951: 13937: 13753: 13125: 13050: 12906: 12826: 12465: 12408: 12344: 12191: 11414: 11375: 11340: 11184: 11149: 11126: 11106: 11060: 11007: 10288: 10243: 10235: 10194: 10145: 10015: 9980: 9945: 9907: 9859: 9785: 9710: 9660: 9622: 9584: 9576: 9529: 9486: 9449: 9400: 9354: 9319: 9282: 9272: 9233: 9193: 9155: 9113: 9105: 9053: 9016: 9008: 8969: 8918: 8882: 8847: 8812: 8777: 8619: 8611: 8570: 8562: 8535: 8515: 8476: 8433: 8391: 8383: 8327: 8290: 8282: 8243: 8208: 8163: 8155: 8106: 8065: 7985: 7950: 7902: 7894: 7828: 7820: 7745: 7737: 7669: 7661: 7614: 7579: 7541: 7533: 7486: 7431: 7384: 7344: 7281: 7246: 7211: 7180: 7140: 7136: 7132: 7091: 7081: 7040: 6999: 6989: 6950: 6914: 6877: 6869: 6764: 6712: 6704: 6663: 6622: 6614: 6573: 6565: 6524: 6516: 6489: 6469: 6432: 6424: 6382: 6345: 6337: 6296: 6286: 6237: 6229: 6188: 6184: 6180: 6139: 6098: 6057: 6053: 6049: 6008: 6000: 5953: 5911: 5901: 5860: 5856: 5852: 5808: 5798: 5757: 5747: 5698: 5651: 5575: 5567: 5526: 5522: 5518: 5477: 5436: 5426: 5385: 5377: 5333: 5323: 5269: 5261: 5214: 5192: 5184: 5127: 5097: 4923:

Case Studies in Medical Toxicology: From the American College of Medical Toxicology

4850: 4754: 4750: 4746: 4686: 4625: 4554: 4515: 4510: 4498: 4468: 4432: 4428: 4390: 4306: 4233: 4191: 4183: 4139: 4131: 4050: 4007: 3999: 3597: 3589: 3537: 3324:) in 1969, and the US patent for it was granted in 1974. It was approved by the US 3207: 3192: 3173: 3059: 2944: 2940: 2877: 2771: 2462: 1816: 1721: 1709: 1537: 1528:

The drug label advises that bupropion should not be prescribed to individuals with

1493: 1464: 1215: 1203: 868: 483: 421: 314: 71: 11011: 10508: 9984: 9911: 9697:

Brustolim D, Ribeiro-dos-Santos R, Kast RE, Altschuler EL, Soares MB (June 2006).

9197: 7883:"Suicidal antidepressant overdoses: a comparative analysis by antidepressant type" 7388: 7318: 7250: 6503:

Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S (2004).

5034: 4854: 4629: 3541: 27394: 27218: 27180: 27175: 26842: 26697: 26554: 26397: 26318: 25565: 25550: 25457: 25432: 25357: 25292: 25137: 25049: 24236: 24017: 23925: 23525: 23515: 23106: 22181: 21660: 20790: 20325: 20313: 20273: 20218: 19869: 19422: 19251: 19113: 19002: 18688: 18389: 17685: 17114: 16329: 16204: 16146: 16134: 15802: 15441: 15073: 15007: 14421: 14309: 14284: 14092: 14080: 13892: 13745: 13334: 13309: 13304: 13264: 13140: 13135: 12997: 12404: 12398: 12211: 11585: 11344: 11188: 11153: 11110: 11084: 9714: 8973: 7435: 7045: 7028: 6918: 6668: 6651: 6473: 6291: 5431: 5328: 5064: 4356: 3455: 3321: 3242: 3071: 2997: 2982: 2843: 1541: 1409: 1312: 1300: 1256: 1015: 453: 429: 193: 26757: 26752: 26747: 20868: 19382: 17631: 17016: 17008: 14151: 12585: 11473: 10199: 10182: 10044: 9698: 6169:"Pharmacological interventions for promoting smoking cessation during pregnancy" 5571: 4887: 1226:

that may be produced by other antidepressants. Bupropion is more effective than

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Strawbridge R, Izurieta E, Day E, Tee H, Young K, Tong CC, et al. (2023).

7583: 6954: 6618: 4558: 4187: 3576:

Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, et al. (2005).

3154: 3143: 3066:

extended-release formulas to maintain a consistent concentration of bupropion.

2874: 2184: 1878: 1874: 1701: 1605: 1584: 1425: 1117:

are weak and clinical significance is contentious. Chemically, bupropion is an

1083: 1075: 1039: 294: 17020: 10935:"EMA advises companies on steps to take avoid nitrosamines in human medicines" 10239: 9949: 9664: 9405: 9388: 9358: 8886: 8437: 8052:

Todor I, Popa A, Neag M, Muntean D, Bocsan C, Buzoianu A, et al. (2016).

7824: 7665: 7490: 5703: 5686: 5188: 4810: 4118:

Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK (April 2016).

1615:

The prescribing information warns about bupropion triggering an angle-closure

1251:

Prescribed as an aid for smoking cessation, bupropion reduces the severity of

27404: 27249: 27170: 26837: 26832: 26737: 26604: 26599: 26514: 26423: 26402: 26376: 26334: 26199: 25943: 25798: 25647: 25570: 25308: 24930: 24915: 24261: 24037: 23807: 23560: 23520: 23080: 22937: 22868: 22698: 22659: 22647: 21939: 21887: 21837: 21521: 21517: 21480: 21463: 21318: 21295: 20590: 20530: 20156: 20134: 20092: 19993: 19787: 19740: 19476: 19145: 18725: 18446: 18181: 17865: 17764: 17738: 17662: 17574: 17404: 17374: 17314: 17264: 17259: 17149: 17119: 17065: 16894: 16709: 16644: 16414: 16198: 16194: 16164: 16130: 16104: 16094: 16049: 16013: 15873: 15817: 15656: 15518: 15498: 15481: 15459: 15380: 15375: 15325: 15289: 15149: 15088: 14814: 14334: 14319: 14279: 14015: 13852: 13824: 13643: 13474: 13319: 13160: 13035: 12923: 12831: 12801: 12416: 12363: 12151: 12023: 11998: 11993: 11933: 11908: 11064: 10667: 10653: 9856:

Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

9580: 9414: 9366: 9277: 9245: 7723: 7419: 6569: 5957: 5736:"Pharmacological Treatments for Patients with Treatment-Resistant Depression" 4683:

Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

4135: 3751: 3719: 3403: 3399: 3317: 3230: 3189: 1862: 1843: 1781: 1761: 1737: 1646: 1619:

attack. On the other hand, bupropion may decrease the risk of development of

1564:, and in children, adolescents and young adults due to the increased risk of 1461: 1413: 1344: 1199: 1190: 1178: 1141: 964:

InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

641: 396: 20: 23256: 14431: 14426: 9323: 8111: 8094: 7741: 7285: 6103: 6086: 5906: 5381: 4685:. Advances in Pharmacology. Vol. 69. Academic Press. pp. 177–216. 4003: 3986:

Masters AR, Gufford BT, Lu JB, Metzger IF, Jones DR, Desta Z (August 2016).

2850:

mg dose) in a PET study. Bupropion has also been shown to increase striatal

27259: 27244: 27195: 26964: 26633: 26594: 26509: 26387: 26342: 26290: 26231: 26189: 25928: 25575: 25353: 25348: 25298: 25279: 24955: 24451: 24436: 24416: 24391: 23827: 23720: 23570: 23462: 23457: 23377: 23352: 23124: 23110: 23084: 22979: 22969: 22880: 22860: 22813: 22754: 22651: 22564: 22549: 22534: 22481: 22465: 22361: 22286: 22253: 22071: 21953: 21867: 21715: 21547: 21383: 21378: 21338: 21290: 21244: 21228: 21078: 20872: 20672: 20522: 20382: 20317: 20224: 20210: 20182: 20170: 20112: 20063: 20053: 20023: 20003: 19978: 19923: 19894: 19884: 19839: 19807: 19795: 19791: 19775: 19720: 19386: 19306: 19156: 19029: 18827: 18811: 18745: 18561: 18540: 18507: 18462: 18324: 18269: 18169: 17893: 17810: 17756: 17746: 17489: 17419: 17414: 17329: 17139: 17129: 17080: 17061: 16859: 16779: 16769: 16349: 16244: 16234: 16059: 16054: 15898: 15868: 15756: 15626: 15504: 15416: 15385: 15340: 15335: 15330: 15174: 15144: 15032: 14941: 14901: 14804: 14724: 14614: 14604: 14416: 14411: 14396: 14391: 14370: 14075: 14001: 13969: 13829: 13816: 13513: 13469: 13339: 13284: 13279: 13165: 13100: 13030: 13015: 12992: 12974: 12617: 12461: 12449: 12359: 12266: 12196: 12186: 12038: 12028: 11928: 11923: 11846: 11841: 11821: 11806: 11760: 11522: 11486: 11428: 11352: 11196: 11161: 11118: 11019: 10257: 10159: 10019: 9992: 9919: 9881: 9797: 9722: 9672: 9634: 9598: 9541: 9498: 9463: 9331: 9296: 9205: 9167: 9127: 9065: 9030: 8981: 8930: 8922: 8894: 8633: 8584: 8566: 8527: 8519: 8488: 8445: 8405: 8339: 8304: 8255: 8220: 8177: 8120: 8079: 7962: 7916: 7842: 7759: 7710: 7697:"Naltrexone + bupropion (Mysimba). Too risky for only modest weight loss". 7683: 7626: 7591: 7555: 7498: 7443: 7396: 7293: 7258: 7223: 7154: 7105: 7054: 7013: 6994: 6962: 6926: 6891: 6778: 6726: 6677: 6636: 6587: 6538: 6481: 6446: 6394: 6359: 6310: 6251: 6233: 6202: 6153: 6144: 6127: 6112: 6071: 6022: 5965: 5925: 5874: 5822: 5771: 5712: 5663: 5589: 5540: 5491: 5464:

Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R (January 2008).

5450: 5413:

Turner EH, Cipriani A, Furukawa TA, Salanti G, de Vries YA (January 2022).

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combination may improve some measures of sexual function in women who have

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Selective serotonin reuptake inhibitors and serotonin receptor modulators:

11387: 10208: 10027: 9957: 9824: 9438:"Analgesic and anti-inflammatory activities of bupropion in animal models" 9237: 8859: 8824: 8789: 8754: 7997: 7086: 7069: 6386: 4310: 4172:"Clinicians' Views on Treatment-Resistant Depression: 2016 Survey Reports" 3290:

This diagram shows the synthesis of bupropion via 3'-chloro-propiophenone.

2962: 50: 33: 27208: 27185: 26857: 26614: 26579: 26549: 26479: 26474: 26449: 26347: 26250: 25903: 25893: 25873: 25827: 25808: 25788: 25767: 25555: 25540: 25475: 25427: 25367: 25338: 25318: 25284: 25212: 25006: 24940: 24486: 24466: 24456: 24421: 24381: 24281: 24212: 24177: 24172: 24162: 23994: 23930: 23885: 23880: 23715: 23675: 23590: 23580: 23555: 23472: 23427: 23392: 23070: 23062: 22973: 22965: 22961: 22941: 22929: 22920: 22900: 22888: 22872: 22856: 22694: 22624: 22569: 22539: 22485: 22473: 22357: 22353: 22282: 22203: 22036: 21943: 21920: 21915: 21904: 21862: 21842: 21817: 21802: 21764: 21578: 21543: 21492: 21484: 21458: 21408: 21398: 21348: 21342: 21334: 21330: 21305: 21260: 21252: 21232: 21220: 21207: 21202: 21171: 21029: 20953: 20775: 20729: 20707: 20657: 20647: 20637: 20606: 20566: 20562: 20554: 20534: 20518: 20509: 20413: 20362: 20258: 20190: 20174: 20146: 20138: 20084: 20072: 20043: 20038: 20028: 20008: 19943: 19938: 19927: 19919: 19915: 19859: 19855: 19847: 19831: 19827: 19815: 19811: 19799: 19783: 19748: 19730: 19570: 19488: 19480: 19298: 19294: 19189: 19185: 19091: 18970: 18954: 18893: 18845: 18823: 18819: 18815: 18803: 18795: 18729: 18669: 18665: 18604: 18585: 18503: 18495: 18437: 18407: 18374: 18360: 18249: 18238: 18209: 18154: 18150: 18008: 17998: 17938: 17869: 17856: 17851: 17831: 17806: 17784: 17768: 17722: 17713: 17708: 17594: 17559: 17539: 17454: 17444: 17399: 17379: 17299: 17229: 17219: 17209: 17204: 17174: 16964: 16959: 16949: 16939: 16884: 16849: 16839: 16834: 16829: 16819: 16759: 16734: 16729: 16649: 16419: 16409: 16354: 16325: 16275: 16219: 16172: 16154: 16089: 16069: 16018: 16008: 15983: 15943: 15938: 15883: 15853: 15832: 15822: 15812: 15772: 15711: 15691: 15681: 15661: 15641: 15601: 15591: 15538: 15467: 15449: 15421: 15406: 15365: 15345: 15294: 15284: 15259: 15219: 15214: 15159: 15129: 15108: 15098: 15083: 15048: 15012: 14977: 14906: 14896: 14886: 14881: 14829: 14809: 14799: 14774: 14754: 14684: 14659: 14634: 14629: 14624: 14589: 14584: 14542: 14537: 14486: 14294: 14098: 14055: 14050: 14020: 13965: 13917: 13877: 13791: 13786: 13766: 13761: 13633: 13569: 13564: 13494: 13484: 13479: 13464: 13453: 13448: 13378: 13349: 13344: 13274: 13244: 13213: 13188: 13150: 13105: 13065: 13055: 13025: 13020: 12918: 12672: 12622: 12379: 12276: 12141: 12076: 12071: 12061: 12018: 12003: 11988: 11978: 11948: 11938: 11811: 11781: 11776: 11722: 11699: 11694: 11666: 11623: 11600: 11590: 11532: 11438: 11255:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. 11078:

Antidepressant Wellbutrin becomes 'poor man's cocaine' on Toronto streets

9696: 8247: 7650:"A review of systemic medications that may modulate the risk of glaucoma" 6691:

Razali NA, Sidi H, Choy CL, Ross NA, Baharudin A, Das S (February 2022).

6520: 6035: 5655: 5504: 5482: 5465: 4735:"Bupropion for attention deficit hyperactivity disorder (ADHD) in adults" 4733:

Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C (October 2017).

4732: 4394: 3593: 3087: 2440: 1847: 1823: 1812: 1808: 1793: 1749: 1693: 1557: 1357: 1308: 1296: 1272: 1231: 1194: 1027: 201: 11331:

Schneier FR (March 2011). "Pharmacotherapy of social anxiety disorder".

10183:"Bupropion metabolites produce false-positive urine amphetamine results" 10072: 8168: 6126:

Selph S, Patnode C, Bailey SR, Pappas M, Stoner R, Chou R (April 2020).

5102: 2985:

of bupropion is unknown but is presumed to be low, at 5–20%, due to the

1792:

have been shown to decrease levels of bupropion and/or its metabolites.

1185:

for the treatment of depression. Some peer-reviewed studies suggest the

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Committee for Medicinal Products for Human Use (CHMP) (23 March 2017).

10866:

Committee for Medicinal Products for Human Use (CHMP) (24 March 2017).

10292: 9837:

Review of bupropion, S G Bryant, B G Guernsey, N B Ingrim, PMID 6140095

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mg/day) and its metabolites in the human brain as measured by several

1645:

The FDA requires all antidepressants, including bupropion, to carry a

1460:

in a number of different formulations. It is formulated mostly as the

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Pandhare A, Pappu AS, Wilms H, Blanton MP, Jansen M (February 2017).

8331: 8286: 6978:"Antidepressants and inflammatory bowel disease: a systematic review" 5167: 4541:

De Vries C, Gadzhanova S, Sykes MJ, Ward M, Roughead E (March 2021).

2993: 1851: 1789: 1773: 1705: 1669: 1390: 1332: 1304: 1095: 1087: 1047: 658: 563: 462: 187: 24: 11710: 11563: 10698:"Drug Approval Package: Aplenzin (Bupropion Hydrobromide) NDA 22108" 8070: 8053: 3252:

to give bupropion as the hydrochloride salt in 75–85% overall yield.

1834:

effects of MDMA. Interactions with other CYP2D6 substrates, such as

27116: 27106: 27101: 27096: 27053: 26989: 26984: 26959: 26939: 26924: 26919: 26822: 26569: 26415: 26255: 26236: 26066: 26056: 26000: 25995: 25933: 25803: 25793: 25783: 25560: 25452: 25377: 24925: 24441: 24396: 24286: 24246: 24241: 24157: 24004: 23865: 23497: 23492: 23482: 23144: 23140: 23118: 23114: 22925: 22904: 22769: 22690: 22673: 22367: 22345: 22329: 22278: 22199: 21929: 21822: 21743: 21693: 21683: 21574: 21539: 21535: 21503: 21310: 21264: 21157: 20969: 20945: 20898: 20771: 20594: 20582: 20484: 20358: 20309: 20296: 20250: 20186: 20178: 20107: 19899: 19879: 19863: 19725: 19690: 19496: 19464: 19412: 19342: 19278: 19274: 19149: 19141: 19095: 19087: 19025: 18983: 18979: 18975: 18889: 18786: 18756: 18721: 18673: 18661: 18600: 18442: 18422: 18417: 18370: 18234: 18224: 18205: 18115: 18105: 18095: 18028: 17948: 17928: 17903: 17881: 17861: 17841: 17802: 17548: 17474: 17289: 17279: 17099: 16854: 16844: 16804: 16799: 16789: 16754: 16704: 16699: 16604: 16443: 16394: 16384: 16283: 16229: 16190: 16168: 15958: 15948: 15741: 15534: 15477: 15463: 15234: 15224: 14926: 14911: 14876: 14734: 14729: 14719: 14689: 14491: 14248: 14065: 13980: 13959: 13943: 13925: 13902: 13862: 13771: 13653: 13574: 13299: 13239: 13145: 13110: 13095: 13060: 12911: 12896: 12836: 12789: 12749: 12744: 12612: 12607: 12136: 12092: 11816: 11801: 11644: 11277:"Autorisation – ZYBAN L.P. 150 mg, comprimé à libération prolongée" 10671: 10562: 9893: 9891: 7202:

Marin RS, Wilkosz PA (2005). "Disorders of diminished motivation".

6975: 2992:

Bupropion is metabolized in the body by a variety of pathways. The

2948: 1745: 1662: 1616: 1587:. It is also associated with about 20% increased risk of headache. 1529: 1361: 1114: 1091: 1059: 1018:

medication in the cases of "incomplete response" to the first-line

780: 772: 703: 229: 24511: 11394: 11218: 10397:"Drug Approval Package: Wellbutrin XL (Bupropion HCI) NDA #021515" 7176:

Novel approaches towards pharmacological enhancement of motivation

6323: 1385:, there have been suggestions that it might be useful in treating 921: 27086: 27048: 27030: 26994: 26954: 26934: 26914: 26656: 26609: 26574: 26504: 26265: 25667: 25632: 25313: 25237: 25222: 24868: 24833: 24823: 24813: 24808: 24803: 24793: 24087: 24067: 24062: 23969: 23905: 23670: 23645: 23640: 23635: 23630: 23625: 23620: 23565: 23382: 23347: 22915: 22809: 22764: 22655: 22514: 22509: 22504: 22499: 22425: 21910: 21774: 21733: 21498: 21423: 21176: 20985: 20832: 20750: 20058: 19988: 19958: 19512: 19347: 19336: 19270: 19177: 19040: 18791: 18487: 18299: 18289: 18279: 18038: 18033: 17923: 17544: 17524: 17104: 17075: 16929: 16924: 16919: 16914: 16904: 16808: 16694: 16629: 16624: 16249: 16079: 16032: 16028: 15978: 15973: 15928: 15918: 15878: 15807: 15686: 15355: 15308: 15304: 15254: 15249: 15204: 15194: 15154: 15078: 14997: 14759: 14749: 14739: 14709: 14654: 14476: 14471: 14466: 14461: 14456: 14451: 14446: 14406: 14304: 14223: 14120: 14088: 13867: 13834: 13433: 13222: 13040: 11958: 11400: 10652:

This article incorporates text from this source, which is in the

5838: 5301: 4791:. In Nemeroff CB, Schatzberg AF, Rasgon N, Strakowski SM (eds.). 3856:"Wellbutrin XL- bupropion hydrochloride tablet, extended release" 3329: 3127: 3018: 2925: 2884: 2789: 1858: 1658: 1597: 1182: 1079: 1063: 1043: 10097: 9888: 9183: 6603:"Evaluation and Management of Hypoactive Sexual Desire Disorder" 3229:

It is synthesized in two chemical steps starting from 3'-chloro-

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Tooltip Noradrenergic and specific serotonergic antidepressants

11505: 11420:

10.1002/1520-6394(2000)12:2<111::AID-DA9>3.0.CO;2-3

10134:"Amphetamine positive toxicology screen secondary to bupropion" 9849: 9847: 9845: 9843: 9179: 9177: 7975: 6084: 5987:

Rosen LJ, Galili T, Kott J, Goodman M, Freedman LS (May 2018).

5247: 4454: 4452: 4450: 3354: 3034: 3030: 3001: 2153: 1877:. The prescribing information recommends minimizing the use of 1800: 1725: 1405: 1401: 1067: 1051: 1026:, and it is more effective than SSRIs at improving symptoms of 811: 466: 10806:

Drug Safety Communication – Mental Health Side Effects Revised

10505:"Seasonal affective disorder drug Wellbutrin XL wins approval" 10151:

10.1002/1520-6394(2000)12:1<53::AID-DA8>3.0.CO;2-4

9853: 9751:

Goodman and Gilman's The Pharmacological Basis of Therapeutics

9043: 8955: 8953: 8951: 8949: 8837: 7417: 7118: 5791:

International Journal of Chronic Obstructive Pulmonary Disease

4789:"Other Antidepressants: Bupropion, Mirtazapine, and Trazodone" 4680: 4418: 1696:

are the two new generation antidepressants (that is excluding

41: 26559: 25717: 25637: 25607: 25157: 25107: 25102: 24975: 24903: 24728: 24693: 24633: 24618: 24032: 23959: 23610: 23312: 22784: 22779: 22026: 21947: 19648: 19601: 17983: 17504: 13663: 11873: 11359: 8466: 8144: 8092: 5640: 5412: 5363: 5116: 4379: 3826:"Wellbutrin SR – bupropion hydrochloride tablet, film coated" 3655:"TGA eBS – Product and Consumer Medicine Information Licence" 2902: 1323:

Bupropion is less likely than other antidepressants to cause

1164: 912: 791: 585: 568: 458: 80: 9840: 9174: 9048:. New Perspectives in Neurotransmitter Transporter Biology. 8959: 8767: 7026: 6649: 6509:

Primary Care Companion to the Journal of Clinical Psychiatry

6264: 6166: 5463: 4447: 3889:"Aplenzin – bupropion hydrobromide tablet, extended release" 3582:

Primary Care Companion to the Journal of Clinical Psychiatry

1315:, which have an immediate onset of effect in the condition. 836: 27136: 26071: 25702: 25657: 25622: 25122: 25112: 24908: 24733: 24718: 24708: 24698: 24688: 24683: 24643: 24638: 24628: 24623: 24608: 24588: 24009: 23502: 22413: 21021: 20820: 20816: 20812: 20405: 19562: 19324: 19320: 19316: 18284: 16333: 13120: 11743: 9897: 9382: 9380: 8994: 8946: 7604: 7230: 5065:"Bupropion Drug Usage Statistics, United States, 2013–2022" 4920:

Dye LR, Murphy C, Calello DP, Levine MD, Skolnik A (2017).

4540: 3527: 2013: 1884:

Caution should be observed when combining bupropion with a

1881:, since in rare cases bupropion reduces alcohol tolerance. 1827: 1819:(a drug that is mainly metabolized by CYP2D6) to its major 1328: 1282: 763: 98: 92: 16:

Medication mainly used for depression and smoking cessation

14855: 11611: 9344: 8831: 8796: 7418:

Alberti S, Chiesa A, Andrisano C, Serretti A (June 2015).

6858:"The search for medications to treat stimulant dependence" 5302:

Hengartner MP, Jakobsen JC, Sørensen A, Plöderl M (2020).

3820: 3818: 3816: 3814: 3812: 3810: 3808: 3806: 3804: 3188:

of 3.6. Pharmaceutically, bupropion is used mainly as the

1692:, adjusted for the number of prescriptions, bupropion and 101: 26544: 22773: 22349: 22211: 20981: 20923: 20336: 19508: 19437: 18741: 17885: 16562: 11305: 10270: 9931: 9929: 9386: 9338: 8597: 8099:

The Journal of Pharmacology and Experimental Therapeutics

7806: 7271: 6600: 5088: 4608: 4169: 4037: 3992:

The Journal of Pharmacology and Experimental Therapeutics

3633: 3422:

Bupropion has been studied limitedly in the treatment of

2891:

receptor activation. They are enhanced and inhibited by σ

77: 16304: 14140:

Drugs for erectile dysfunction and premature ejaculation

13741: 11365: 10363:"Bupropion helps people with schizophrenia quit smoking" 9964: 9563:

Chen WC, Lai HC, Su WP, Palani M, Su KP (January 2015).

9476: 9377: 9309: 8907: 8761: 8504: 8317: 8268: 8198: 7648:

Wu A, Khawaja AP, Pasquale LR, Stein JD (January 2020).

7519: 7236: 6125: 6038:"Relapse prevention interventions for smoking cessation" 5787:"The use of bupropion SR in cigarette smoking cessation" 4117: 2887:. Its antidepressant-like effects in rodents depend on σ 2679: 2658: 2636: 2610: 2580: 2550: 2520: 2490: 23368: 12965: 12579: 11174: 9303: 9222: 8369: 7265: 6502: 4458: 3985: 3848: 3801: 1633:

Bupropion has rarely been associated with instances of

1154:

World Health Organization's List of Essential Medicines

26625: 16985: 16581: 15846:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

15122:

Serotonin–norepinephrine–dopamine reuptake inhibitors:

10005: 9926: 9774: 9747: 9216: 8901: 7647: 7568: 7476: 7067: 6215: 5986: 5888:

Wu P, Wilson K, Dimoulas P, Mills EJ (December 2006).

5554:

Li DJ, Tseng PT, Chen YW, Wu CK, Lin PY (March 2016).

4919: 1475:

mg), SR (sustained-release) tablets (50, 100, 150, 200

27378: 24010: 23503: 15565: 10837:"Glaxo agrees to pay $ 3 billion in fraud settlement" 10221: 10181:

Nixon AL, Long WH, Puopolo PR, Flood JG (June 1995).

10180: 9754:(12th ed.). New York: McGraw-Hill Professional. 9650: 9087: 9085: 9083: 8802: 5887: 4170:

Arandjelovic K, Eyre HA, Lavretsky H (October 2016).

3883: 3881: 3233:. The alpha position adjacent to the ketone is first 1552:. It should be avoided in individuals who are taking 1479:

mg), and XL (extended-release) tablets (150, 300, 450

124: 114: 104: 14202: 11715:

Tooltip Serotonin antagonist and reuptake inhibitors

11568:

Tooltip Serotonin–norepinephrine reuptake inhibitors

10497: 10222:

Casey ER, Scott MG, Tang S, Mullins ME (June 2011).

10073:"Bupropion: Uses, Interactions, Mechanism of Action" 9741: 9258: 9141: 9139: 9137: 8734: 8711: 8709: 8051: 7807:

Henssler J, Heinz A, Brandt L, Bschor T (May 2019).

7027:

Thorkelson G, Bielefeldt K, Szigethy E (June 2016).

6410: 4840: 4074:(37th ed.). Pharmaceutical Press. p. 402. 3575: 3255: 95: 89: 86: 74: 27441:

Attention deficit hyperactivity disorder management

24193: 12049: 11649:

Tooltip Norepinephrine–dopamine reuptake inhibitors

10997: 9970: 7940: 7880: 7373: 7179:(Thesis). University of Cambridge. pp. 13–14. 6982:

Clinical Practice and Epidemiology in Mental Health

6753:"Meta-analysis: pharmacologic treatment of obesity" 6601:Clayton AH, Kingsberg SA, Goldstein I (June 2018). 3618: 3058:of 12–30 hours), while the effective doses of 1412:. Accordingly, the drug has been found to increase 691: 83: 14844: 12659: 10621: 10619: 10617: 10367:National Institute on Drug Abuse Research Findings 9435: 9080: 8866: 8026:. U.S. Food and Drug Administration. August 2020. 7345:"Bupropion/Dextromethorphan – Axsome Therapeutics" 7337: 6819: 6750: 6690: 6375:Journal of Child and Adolescent Psychopharmacology 5733: 3878: 3448: 3126:-butylcathinone. The clinically used bupropion is 2287: 1078:is notable. Rare but serious side effects include 24138: 23846: 17661: 14181: 11891: 11310:(69 ed.). London, UK: Pharmaceutical Press. 10091: 9935: 9858:. Adv Pharmacol. Vol. 69. pp. 177–216. 9134: 8706: 8645: 8643: 8058:Journal of Pharmacy & Pharmaceutical Sciences 8011: 8009: 8007: 7858:The Maudsley prescribing guidelines in psychiatry 7855: 7809:"Antidepressant Withdrawal and Rebound Phenomena" 7068:Eskeland S, Halvorsen JA, Tanum L (August 2017). 6411:Wilens TE, Morrison NR, Prince J (October 2011). 5834: 5832: 4782: 4780: 4778: 4269: 4223: 27402: 12114: 10993: 10991: 9692: 9690: 9646: 9644: 9519: 8500: 8498: 8419: 8417: 8415: 8365: 8363: 8361: 8359: 8357: 8140: 8138: 7936: 7934: 7932: 7930: 7928: 7926: 7195: 7121:"Antidepressants for non-specific low back pain" 6939: 4296: 4113: 4111: 2730: 1799:Bupropion and its metabolites are inhibitors of 671: 27300:GlaxoSmithKline Services Unlimited v Commission 12451: 11510:Tooltip Selective serotonin reuptake inhibitors 10614: 10131: 10104:. Medpharm Scientific Publishers. p. 173. 9562: 8740: 7881:White N, Litovitz T, Clancy C (December 2008). 7168: 7166: 7164: 6746: 6744: 6406: 6404: 5939: 5937: 5935: 5636: 5634: 5359: 5357: 5297: 5295: 5293: 5243: 5241: 5239: 5163: 5161: 5159: 5157: 4836: 4834: 4832: 4728: 4726: 4724: 4722: 4720: 4718: 4676: 4674: 4672: 4670: 4604: 4602: 4600: 4598: 4596: 4536: 4534: 4492: 4490: 4414: 4412: 4375: 4373: 4344: 4342: 4340: 4338: 4336: 4265: 4263: 4165: 4163: 4109: 4107: 4105: 4103: 4101: 4099: 4097: 4095: 4093: 4091: 3981: 3979: 3948: 3946: 3944: 3523: 3521: 3519: 3517: 3515: 3513: 3511: 3509: 3507: 3505: 3503: 3501: 3110:-butyl-β-keto-α-methylphenethylamine, 3-chloro- 2981:of 3 hours and 5 hours, respectively. Absolute 2734: 1098:may be associated with increased likelihood of 1042:of bupropion with the greatest difference from 634: 24148: 23856: 17480:Trimetaphan camsilate (trimethaphan camsylate) 11034: 11000:The American Journal of Drug and Alcohol Abuse 10356: 10354: 8640: 8548: 8004: 7321:. United States Food and Drug Administration. 6459: 5943: 5829: 4882: 4880: 4795:. American Psychiatric Pub. pp. 365–374. 4775: 3571: 3569: 3567: 3499: 3497: 3495: 3493: 3491: 3489: 3487: 3485: 3483: 3481: 2935:Bupropion has been found to have a mixture of 1901:Pharmacology of bupropion and its metabolites 27516:World Health Organization essential medicines 26641: 24527: 23286: 23272: 20069:Serotonin antagonists and reuptake inhibitors 17647: 17621:Acetylcholine metabolism/transport modulators 16535: 15770:Serotonin–norepinephrine reuptake inhibitors: 15554: 15046:Serotonin–norepinephrine reuptake inhibitors: 14874:Selective norepinephrine reuptake inhibitors: 14167: 13727: 12951: 12565: 11454: 11324: 11168: 11139: 10988: 10834: 10125: 9768: 9687: 9641: 9605: 9556: 9513: 9470: 9429: 9252: 9091: 8988: 8937: 8872: 8682: 8680: 8495: 8460: 8423: 8412: 8354: 8311: 8262: 8227: 8192: 8135: 8086: 7923: 7800: 5734:Ruberto VL, Jha MK, Murrough JW (June 2020). 5684: 5553: 2910:Tooltip half-maximal inhibitory concentration 2338: 1508:mg extended-release tablets) for obesity and 17616:Muscarinic acetylcholine receptor modulators 14960:Norepinephrine–dopamine reuptake inhibitors: 14191: 11403:"Bupropion-SR in treatment of social phobia" 10174: 10067: 10065: 9804: 9145: 7969: 7717: 7690: 7641: 7598: 7562: 7513: 7470: 7411: 7367: 7313: 7311: 7309: 7307: 7305: 7303: 7201: 7161: 7112: 7061: 7020: 6969: 6898: 6849: 6741: 6684: 6643: 6594: 6545: 6496: 6453: 6401: 6366: 6317: 6258: 6209: 6160: 6119: 6078: 5932: 5881: 5727: 5678: 5631: 5547: 5498: 5457: 5406: 5354: 5290: 5236: 5154: 5110: 4989: 4987: 4829: 4715: 4667: 4593: 4531: 4496: 4487: 4409: 4370: 4333: 4260: 4176:The American Journal of Geriatric Psychiatry 4160: 4088: 3976: 3941: 3146:on bupropion can be separated, they rapidly 3102:. It is also known structurally as 3-chloro- 2236: 1431:Bupropion has been used in the treatment of 233: 27481:Norepinephrine–dopamine reuptake inhibitors 12485: 12302: 12242: 11748:Tooltip Serotonin modulator and stimulators 10668:"FDA Approvals: Advair, Relistor, Aplenzin" 10351: 10101:Index Nominum: International Drug Directory 10039: 10037: 7775: 7125:The Cochrane Database of Systematic Reviews 6904: 6551: 6173:The Cochrane Database of Systematic Reviews 6042:The Cochrane Database of Systematic Reviews 5845:The Cochrane Database of Systematic Reviews 5511:The Cochrane Database of Systematic Reviews 4959: 4957: 4955: 4877: 4739:The Cochrane Database of Systematic Reviews 3681:Brazilian Health Regulatory Agency (Anvisa) 3564: 3478: 2420: 2394: 1193:report that bupropion has an at-most small 617:-Butylamino)-1-(3-chlorophenyl)propan-1-one 413:In general: ℞ (Prescription only) 26648: 26634: 24534: 24520: 23279: 23265: 17654: 17640: 16542: 16528: 14860:Tooltip Norepinephrine reuptake inhibitors 14174: 14160: 13734: 13720: 12958: 12944: 12875: 12769: 12729: 12629: 12572: 12558: 11616:Tooltip Norepinephrine reuptake inhibitors 11468: 11461: 11447: 10431:"Drug Approval Package: Zyban NDA# 020711" 8677: 8663:Psychoactive Drug Screening Program (PDSP) 5198:11370/842b1441-d0f3-4797-b95b-3a6a72262150 4915: 4913: 4786: 4618:The World Journal of Biological Psychiatry 4219: 4217: 4215: 4124:Therapeutic Advances in Psychopharmacology 2966:Principal pathways of bupropion metabolism 2756:norepinephrine–dopamine reuptake inhibitor 1107:norepinephrine–dopamine reuptake inhibitor 850: 731: 16567:Tooltip Nicotinic acetylcholine receptors 11418: 11211: 11054: 11040: 10963: 10558:"Report questions generic antidepressant" 10247: 10198: 10149: 10098:Schweizerischer Apotheker-Verein (2004). 10062: 9748:Brunton L, Chabner B, Knollman B (2010). 9588: 9453: 9404: 9286: 9276: 9117: 9020: 8623: 8574: 8395: 8294: 8167: 8110: 8069: 7906: 7849: 7832: 7749: 7673: 7545: 7300: 7144: 7095: 7085: 7044: 7003: 6993: 6881: 6862:Addiction Science & Clinical Practice 6768: 6716: 6667: 6626: 6577: 6528: 6436: 6349: 6300: 6290: 6241: 6192: 6143: 6102: 6061: 6012: 5980: 5915: 5905: 5864: 5812: 5802: 5761: 5751: 5702: 5579: 5530: 5481: 5440: 5430: 5389: 5337: 5327: 5273: 5196: 5101: 4984: 4758: 4514: 4195: 4143: 4054: 4011: 3771: 3601: 1433:postural orthostatic tachycardia syndrome 751: 17110:Candocuronium iodide (chandonium iodide) 16309:Tooltip Vesicular monoamine transporters 15584:Selective serotonin reuptake inhibitors: 12343: 11330: 11096: 10724: 10523: 10034: 9810: 9259:Pei Y, Asif-Malik A, Canales JJ (2016). 8233: 7172: 4952: 4350:"Wellbutrin XL® Prescribing Information" 4069: 4033: 4031: 3303: 3241:of the resulting alpha-bromoketone with 2961: 2684:Tooltip human Ether-à-go-go-Related Gene 1289:attention deficit hyperactivity disorder 1283:Attention deficit hyperactivity disorder 1163: 27293:Christopher v. SmithKline Beecham Corp. 23408:Dehydroepiandrosterone sulfate (DHEA-S) 23373:Tooltip Calcitonin gene-related peptide 10812:(FDA). 16 December 2016. Archived from 10665: 10555: 10360: 8649: 7319:"Drugs@FDA: FDA Approved Drug Products" 6855: 6770:10.7326/0003-4819-142-7-200504050-00012 5841:"Antidepressants for smoking cessation" 5602: 5082: 4910: 4212: 4072:Martindale: The Complete Drug Reference 3027:11β-hydroxysteroid dehydrogenase type 1 2768:norepinephrine–dopamine releasing agent 1678:antidepressant discontinuation syndrome 1287:In the United States, the treatment of 1228:selective serotonin reuptake inhibitors 846: 711: 206: 27403: 16990:Tooltip negative allosteric modulators 16586:Tooltip positive allosteric modulators 10549: 8320:Clinical Pharmacology and Therapeutics 8275:Clinical Pharmacology and Therapeutics 7978:Journal of Clinical Psychopharmacology 7771: 7769: 7424:Journal of Clinical Psychopharmacology 7355:from the original on 21 September 2021 6462:Journal of Clinical Psychopharmacology 5784: 4063: 3379: 3118:-butyl-β-ketoamphetamine, or 3-chloro- 1020:selective serotonin reuptake inhibitor 405: 377: 26768:Recherche et Industrie Thérapeutiques 26629: 24515: 23260: 17635: 16523: 15570:Tooltip Serotonin reuptake inhibitors 14155: 13715: 12939: 12553: 12438: 12342: 12113: 11872: 11485: 11442: 11250: 10945:from the original on 11 November 2023 10637:from the original on 13 December 2019 10307:"Wellbutrin entry in the Orange Book" 8717:"Bupropion – Biological Test Results" 7325:from the original on 16 November 2016 5224:from the original on 27 February 2022 5096:. Geneva: World Health Organization. 5015:from the original on 27 November 2020 4963: 4028: 3960:. GlaxoSmithKline UK. 1 August 2013. 3466:from the original on 24 December 2018 3281: 3276: 3044:and by yet unknown enzyme leading to 2011: 1961: 1318: 819: 799: 390: 224: 192: 158:-butyl-β-keto-α-methylphenethylamine; 21583:methylergometrine (methylergonovine) 20543:N-desalkylquetiapine (norquetiapine) 20379:methylergometrine (methylergonovine) 19525:methylergometrine (methylergonovine) 19154:methylergometrine (methylergonovine) 19100:methylergometrine (methylergonovine) 18459:methylergometrine (methylergonovine) 17890:methylergometrine (methylergonovine) 14207:Tooltip Dopamine reuptake inhibitors 11299: 11244: 10976:from the original on 11 October 2023 10915:from the original on 19 January 2021 10878:from the original on 26 October 2020 10835:Thomas K, Schmidt MS (2 July 2012). 10485:from the original on 1 November 2020 10445:from the original on 5 December 2019 10411:from the original on 5 December 2019 9999: 9729:from the original on 16 October 2023 9522:Naunyn-Schmiedeberg's Arch Pharmacol 9092:Sałaciak K, Pytka K (January 2022). 8549:Stuebler AG, Jansen M (March 2020). 8033:from the original on 19 October 2020 7856:Taylor D, Carol P, Shitij K (2012). 4972:from the original on 7 November 2017 3899:from the original on 26 October 2020 3661:from the original on 7 December 2016 3271: 3021:leading to 4'-hydroxybupropion. The 2713:nM at a variety of other sites (5-HT 1523: 1372:(FDA) for the treatment of obesity. 1246: 1152:million prescriptions. It is on the 313: 26683:GlaxoSmithKline Pharmaceuticals Ltd 26540:Lysergic acid 2,4-dimethylazetidide 24541: 24198:Tooltip 3,4,5-Trimethoxyamphetamine 20547:N-desmethylclozapine (norclozapine) 12054:Tooltip Tetracyclic antidepressants 10712:from the original on 15 August 2020 10507:. CNN. 14 June 2006. Archived from 8426:Cellular and Molecular Neurobiology 7766: 5045:from the original on 30 August 2024 4940:from the original on 29 August 2021 3929:from the original on 18 August 2022 3866:from the original on 9 January 2023 3789:from the original on 9 January 2023 3759:from the original on 9 January 2023 3727:from the original on 9 January 2023 3398:In Russia bupropion is banned as a 3384: 3195:but also to a lesser extent as the 2957: 2873:Bupropion has been claimed to be a 2210: 1532:or other conditions that lower the 1488:mg, equivalent to 150, 300, and 450 1467:but also to a lesser extent as the 779: 771: 662: 13: 15904:Didesmethylsibutramine (BTS-54505) 15180:Didesmethylsibutramine (BTS-54505) 14849:Tooltip Norepinephrine transporter 14610:Didesmethylsibutramine (BTS-54505) 11306:Joint Formulary Committee (2015). 11229:from the original on 20 April 2013 10738:(FDA). 1 July 2009. Archived from 10531:"Generic drug equality questioned" 10339:from the original on 6 August 2013 9864:10.1016/B978-0-12-420118-7.00005-6 9627:10.1016/j.transproceed.2013.04.010 8236:The Journal of Clinical Psychiatry 7813:Deutsches Ärzteblatt International 7730:Postepy Dermatologii I Alergologii 7572:The Canadian Journal of Cardiology 7351:. Springer Nature Switzerland AG. 6417:Expert Review of Neurotherapeutics 6372: 5946:Expert Review of Neurotherapeutics 5685:Naguy A, Badr BHM (October 2022). 5644:The Journal of Clinical Psychiatry 4691:10.1016/B978-0-12-420118-7.00005-6 4503:The American Journal of Psychiatry 4473:10.1016/j.genhosppsych.2011.07.001 4421:The American Journal of Psychiatry 4383:The Journal of Clinical Psychiatry 4272:The Journal of Clinical Psychiatry 3695:from the original on 3 August 2023 3402:, due to it being a derivative of 2825:muscarinic acetylcholine receptors 2292:Tooltip Norepinephrine transporter 1720:Since bupropion is metabolized to 1438: 1398:disorders of diminished motivation 1177:The evidence overall supports the 14: 27527: 27307:United States v. Glaxo Group Ltd. 24372:Chlorphenamine (chlorpheniramine) 24143:Tooltip N,N-Diisopropyltryptamine 23851:Tooltip N,N-Diisopropyltryptamine 17195:Dimethyltubocurarine (metocurine) 14422:Etybenzatropine (ethybenztropine) 12439: 11896:Tooltip Tricyclic antidepressants 11287:from the original on 9 April 2023 10847:from the original on 2 March 2017 10533:. 12 October 2007. Archived from 10335:. eMedExpert.com. 31 March 2008. 9436:Hajhashemi V, Khanjani P (2014). 7458:from the original on 8 March 2023 7173:Hailwood JM (27 September 2018). 6709:10.2174/1570159X20666220222145735 4898:from the original on 29 July 2018 4817:from the original on 8 March 2023 4581:from the original on 7 March 2023 4497:Nelson JC, Spyker DA (May 2017). 3964:from the original on 20 July 2017 2930:trace amine-associated receptor 1 2868:norepinephrine reuptake inhibitor 2764:nicotinic acetylcholine receptors 1668:In rare cases, bupropion-induced 1578:List of side effects of bupropion 1396:Bupropion has been used to treat 1337:hypoactive sexual desire disorder 1230:(SSRIs) at improving symptoms of 944:O=C(C(C)NC(C)(C)C)C1=CC=CC(Cl)=C1 340: 256: 27388: 27361: 27360: 27314:United States v. GlaxoSmithKline 16551:Nicotinic acetylcholine receptor 15894:Desmethylsibutramine (BTS-54354) 15170:Desmethylsibutramine (BTS-54354) 14600:Desmethylsibutramine (BTS-54354) 12832:Hydromorphone (extended-release) 11380:10.1097/00004714-199108000-00023 11308:British National Formulary (BNF) 11269: 11133: 11090: 11071: 10964:Lipanovic D (6 September 2023). 10957: 10927: 10890: 10859: 10828: 10794: 10754: 10690: 10678:from the original on 6 July 2022 10659: 10647: 10457: 10423: 10389: 10325: 10299: 10264: 10215: 9831: 9790:10.1097/00008571-200404000-00002 9160:10.1111/j.1472-8206.2008.00605.x 9058:10.1016/j.neuropharm.2005.05.004 9037: 9013:10.1016/j.neuroimage.2009.11.077 8616:10.1016/j.neuropharm.2016.09.021 8591: 8542: 8469:European Journal of Pharmacology 8045: 7990:10.1097/00004714-199510000-00004 7874: 7860:. West Sussex: Wiley-Blackwell. 7619:10.2165/00002018-200225020-00004 7377:Expert Opinion on Emerging Drugs 7216:10.1097/00001199-200507000-00009 6907:European Journal of Pharmacology 6837:from the original on 4 June 2020 6807:from the original on 4 June 2020 4238:10.2165/00003495-200868050-00011 3836:from the original on 4 June 2020 3715:"Wellbutrin Product information" 3456:"Bupropion Use During Pregnancy" 3263: 3150:under physiological conditions. 998:, and sold under the brand name 888: 885: 879: 70: 49: 40: 27471:Female sexual dysfunction drugs 27331:Drug Industry Documents Archive 25471:N,alpha-Diethylphenylethylamine 23235:Monoamine metabolism modulators 17575:Meclofenoxate (centrophenoxine) 16900:Suxethonium (succinyldicholine) 16895:Suxamethonium (succinylcholine) 16505:Monoamine metabolism modulators 10939:European Medicines Agency (EMA) 10132:Weintraub D, Linder MW (2000). 9110:10.1016/j.neubiorev.2021.10.037 8686: 7955:10.1016/j.clinthera.2005.11.011 6933: 6785: 6029: 5778: 5596: 5057: 5027: 4655:from the original on 5 May 2022 4290: 3958:electronic Medicines Compendium 3911: 3393: 3184:compound, with an experimental 2945:modulation of the immune system 2216:Bupropion binding and activity 1895: 1715: 1571: 1159: 969:Key:SNPPWIUOZRMYNY-UHFFFAOYSA-N 27286:Canada v. GlaxoSmithKline Inc. 24153:Tooltip N,N-Dipropyltryptamine 23861:Tooltip N,N-Dipropyltryptamine 23561:Pentoxyverine (carbetapentane) 11087:Global News 18 September 2013. 10775:(1): 1–4. 2009. Archived from 8376:Journal of Medicinal Chemistry 7705:(164): 229–233. October 2015. 7479:Journal of Affective Disorders 7137:10.1002/14651858.CD001703.pub3 6185:10.1002/14651858.CD010078.pub3 6054:10.1002/14651858.CD003999.pub6 5857:10.1002/14651858.CD000031.pub6 5523:10.1002/14651858.CD011268.pub3 5177:Journal of Affective Disorders 4751:10.1002/14651858.CD009504.pub2 4516:10.1176/appi.ajp.2016.16050523 4433:10.1176/appi.ajp.2013.13050709 3919:"Bupropion hydrochloride EPAR" 3739: 3707: 3673: 3647: 3409: 3278:3'-chloro-2-bromopropiophenone 3098:and the more general class of 2916:nM. In contrast to many other 2766:. Bupropion does not act as a 1690:US National Poison Data System 1640: 1350: 1293:American Academy of Pediatrics 891: 873: 366: 353: 1: 24502:Receptor/signaling modulators 23398:Dehydroepiandrosterone (DHEA) 23222:Monoamine reuptake inhibitors 23186:Receptor/signaling modulators 17611:Receptor/signaling modulators 17265:Hexamethonium (benzohexonium) 16485:Receptor/signaling modulators 15559:Tooltip Serotonin transporter 14183:Monoamine reuptake inhibitors 11253:Australian Medicines Handbook 11177:Journal of Addiction Medicine 11142:Journal of Addiction Medicine 11099:Journal of Addictions Nursing 11012:10.1080/00952990.2018.1545023 10556:Stenson J (12 October 2007). 10273:Journal of Chemical Education 10228:Journal of Medical Toxicology 9985:10.1080/00952990.2018.1545023 9912:10.1080/03602532.2019.1620763 9198:10.1080/14728222.2020.1805435 8852:10.1016/s0014-2999(97)01393-9 8481:10.1016/S0014-2999(03)02010-7 8213:10.1016/s0149-2918(08)80047-1 7887:Journal of Medical Toxicology 7389:10.1080/14728214.2021.1898588 7251:10.1080/14656566.2024.2319224 6342:10.1016/S2215-0366(18)30269-4 5266:10.1016/S0140-6736(17)32802-7 5132:10.1016/S0140-6736(09)60046-5 4995:"Wellbutrin approval package" 4855:10.1080/10550887.2022.2028531 4787:DeBattista C (16 June 2022). 4630:10.1080/15622975.2021.1878427 3542:10.1080/03602532.2019.1620763 3441: 2760:negative allosteric modulator 2343:Tooltip Serotonin transporter 1700:) that result in the highest 1453:Bupropion is available as an 1375: 1172: 1111:nicotinic receptor antagonist 362:(Other controlled substances) 55:1 : 1 mixture (racemate) 15399:Tetracyclic antidepressants: 14196:Tooltip Dopamine transporter 12116:Monoamine oxidase inhibitors 11345:10.1517/14656566.2011.534983 11189:10.1097/ADM.0000000000000249 11154:10.1097/ADM.0b013e3182824863 11111:10.3109/10884602.2011.647838 10810:Food and Drug Administration 10736:Food and Drug Administration 10704:Food and Drug Administration 10631:Food and Drug Administration 10595:Food and Drug Administration 10474:Food and Drug Administration 10437:Food and Drug Administration 10403:Food and Drug Administration 9715:10.1016/j.intimp.2005.12.007 8974:10.1097/FTD.0000000000001142 8782:10.1016/0014-2999(86)90596-0 7782:Food and Drug Administration 7436:10.1097/JCP.0000000000000329 7046:10.1097/MIB.0000000000000734 6919:10.1016/j.ejphar.2016.03.040 6799:Food and Drug Administration 6669:10.1016/j.mayocp.2016.09.018 6474:10.1097/JCP.0b013e3181a5233f 6292:10.1371/journal.pone.0240584 5432:10.1371/journal.pmed.1003886 5329:10.1371/journal.pone.0229381 5004:Food and Drug Administration 3336:In 1996, the FDA approved a 3326:Food and Drug Administration 3224: 3206:of bupropion exist, such as 3081: 3037:in the intestine leading to 2856:dopamine reuptake inhibition 2840:positron emission tomography 2241:Tooltip Dopamine transporter 1888:(MAOI), as it may result in 1554:monoamine oxidase inhibitors 1520:mg tablets) for depression. 1370:Food and Drug Administration 1368:has been approved by the US 1269:nicotine replacement therapy 7: 26535:Lysergic acid 2-butyl amide 23586:Racemethorphan (methorphan) 23055:Tetracyclic antidepressants 22630:Tetracyclic antidepressants 21893:Tetracyclic antidepressants 21469:Tetracyclic antidepressants 20718:Tetracyclic antidepressants 20123:Tetracyclic antidepressants 17345:Methorphan (racemethorphan) 16675:Bephenium hydroxynaphthoate 15849:3,3-Diphenylcyclobutanamine 15125:3,3-Diphenylcyclobutanamine 13956:conjugated equine estrogens 12837:Morphine (extended-release) 12310:Tooltip Monoamine oxidase B 12250:Tooltip Monoamine oxidase A 11879:tetracyclic antidepressants 9813:Psychopharmacology Bulletin 7033:Inflammatory Bowel Diseases 6757:Annals of Internal Medicine 5572:10.1097/MD.0000000000003165 4461:General Hospital Psychiatry 4359:. June 2006. Archived from 3747:"Zyban Product information" 3429: 3417: 3320:of Burroughs Wellcome (now 3130:, that is a mixture of two 3100:substituted phenethylamines 2952:tumor necrosis factor alpha 1886:monoamine oxidase inhibitor 1683: 1212:seasonal affective disorder 1135:substituted phenethylamines 1129:and more generally that of 1014:. It is also popular as an 10: 27532: 27461:Drugs developed by GSK plc 26545:Lysergic acid diethylamide 16725:Dimethylphenylpiperazinium 16489:Monoamine releasing agents 16047:Tricyclic antidepressants: 15323:Tricyclic antidepressants: 14392:Benzatropine (benztropine) 12880:Tooltip Adrenergic agonist 12774:Tooltip Adrenergic agonist 12734:Tooltip Adrenergic agonist 12634:Tooltip Adrenergic agonist 11787:Dextromethorphan/bupropion 10970:The Pharmaceutical Journal 9534:10.1007/s00210-023-02462-0 9491:10.1007/s10787-021-00829-4 8148:Medicinal Research Reviews 8024:Currax Pharmaceuticals LLC 7584:10.1016/j.cjca.2013.09.014 7074:Acta Dermato-Venereologica 6955:10.1007/s40263-023-01032-5 6619:10.1016/j.esxm.2018.01.004 6552:Basson R, Gilks T (2018). 5615:(1): 55–61. Archived from 5106:. WHO/MHP/HPS/EML/2023.02. 4559:10.1007/s40264-020-01027-x 4188:10.1016/j.jagp.2016.05.010 3691:(published 4 April 2023). 3316:Bupropion was invented by 3299: 2860:norepinephrine transporter 1575: 1510:dextromethorphan/bupropion 1449:Dextromethorphan/bupropion 1442: 1387:inflammatory bowel disease 1299:, bupropion has a delayed 1140:Bupropion was invented by 1113:. However, its effects on 863:Chemical and physical data 18: 27356: 27323: 27277: 27227: 27156: 27149: 27023: 26902: 26810: 26803: 26796: 26788:Smith, Kline & French 26723: 26707: 26670: 26663: 26437: 26198: 26087: 26024: 25836: 25766: 25090: 24549: 24495: 24221: 23944: 23297: 23176: 23133: 23077:Tricyclic antidepressants 22995:Metitepine (methiothepin) 22845: 22742: 22730: 22683: 22644:Tricyclic antidepressants 22575:Metitepine (methiothepin) 22449: 22322: 22310: 22259:Metitepine (methiothepin) 22241: 22192: 22180: 22125: 22014: 22002: 21972: 21752: 21630: 21618: 21600: 21562: 21514:Tricyclic antidepressants 21389:Metitepine (methiothepin) 21195: 20801: 20789: 20764: 20633:Metitepine (methiothepin) 20502: 20284: 20272: 20243: 20153:Tricyclic antidepressants 19984:Metitepine (methiothepin) 19708: 19262: 19250: 19238: 19217:Metitepine (methiothepin) 19209: 19124: 19112: 19080: 19072:Metitepine (methiothepin) 19064: 19013: 19001: 18963: 18935:Metitepine (methiothepin) 18867: 18699: 18687: 18654: 18626:Metitepine (methiothepin) 18549: 18400: 18388: 18353: 18275:Metitepine (methiothepin) 18139: 17696: 17684: 17672: 17603: 17517: 16978: 16574: 16560: 16477: 16433: 16302: 16113: 16042: 15841: 15765: 15579: 15552: 15430: 15394: 15318: 15117: 15041: 14955: 14869: 14842: 14525: 14379: 14343: 14267: 14216: 14189: 14131: 13990: 13916: 13843: 13815: 13752: 13672: 13606: 13588: 13552: 13527: 13504: 13412: 13362: 13232: 13174: 12991: 12982: 12866:Benzodiazepine dependence 12864: 12758: 12648: 12593: 12510: 12445: 12434: 12351: 12338: 12300: 12240: 12126: 12122: 12109: 12085: 12047: 11889: 11885: 11868: 11769: 11741: 11708: 11675: 11642: 11609: 11561: 11503: 11499: 11481: 11043:Current Neuropharmacology 10906:European Medicines Agency 10872:European Medicines Agency 10240:10.1007/s13181-010-0131-5 10200:10.1093/clinchem/41.6.955 9950:10.3109/00498258709043939 9665:10.1016/j.pbb.2020.173073 9406:10.1016/j.nsa.2022.101014 9359:10.1017/S1092852923001396 9226:Drug Development Research 8805:Psychopharmacology (Berl) 7825:10.3238/arztebl.2019.0355 7666:10.1038/s41433-019-0603-z 7491:10.1016/j.jad.2018.04.047 5704:10.1017/S1092852921000365 5687:"Bupropion-myth-busting!" 5189:10.1016/j.jad.2018.04.040 5090:World Health Organization 4964:Mehta NB (25 June 1974). 4039:World Health Organization 3923:European Medicines Agency 3370:European Medicines Agency 3239:nucleophilic displacement 3142:-bupropion. Although the 3017:and, to a lesser degree, 2701: 2183: 2152: 2122: 2092: 2069: 2046: 2023: 1991: 1966: 1947: 1935: 1923: 1911: 1908: 1905: 1867:tricyclic antidepressants 1698:tricyclic antidepressants 1661:(about 40% increase) and 1008:major depressive disorder 977: 952: 932: 910: 897: 867: 862: 830: 810: 790: 762: 742: 722: 702: 682: 657: 625: 597: 592: 562: 511: 473: 452: 438: 428: 420: 330: 325: 300: 285: 270: 244: 214: 200: 182: 168:-butyl-β-ketoamphetamine; 146: 142:Wellbutrin, Zyban, others 136: 65: 60: 48: 39: 27411:3-Chlorophenyl compounds 26778:S. E. Massengill Company 26678:GlaxoSmithKline Pakistan 25435:(Dextromethamphetamine, 23463:Fabomotizole (afobazole) 23438:Dimethyltryptamine (DMT) 22565:Latrepirdine (dimebolin) 22254:Latrepirdine (dimebolin) 21579:ergometrine (ergonovine) 21379:Latrepirdine (dimebolin) 20776:ergometrine (ergonovine) 19489:ergometrine (ergonovine) 19092:ergometrine (ergonovine) 18670:ergometrine (ergonovine) 18375:ergometrine (ergonovine) 17585:Phosphatidylethanolamine 15773:Atomoxetine (tomoxetine) 15049:Atomoxetine (tomoxetine) 12493:Rubidium chloride (RbCl) 11333:Expert Opin Pharmacother 11281:agence-prd.ansm.sante.fr 11065:10.2174/1570159033360566 10666:Waknine Y (8 May 2008). 10361:Whitten L (April 2006). 10333:"Bupropion (Wellbutrin)" 9581:10.4306/pi.2015.12.1.142 9278:10.3389/fnins.2016.00148 9186:Expert Opin Ther Targets 7239:Expert Opin Pharmacother 6856:Kampman KM (June 2008). 6570:10.1177/1745506518762664 5958:10.1586/14737175.6.7.965 4926:. Springer. p. 85. 4136:10.1177/2045125316629071 3341:and XL are available in 1635:Stevens–Johnson syndrome 1628:congenital heart defects 1131:substituted amphetamines 1100:congenital heart defects 1006:primarily used to treat 448:Threohydrobupropion: 42% 19:Not to be confused with 27486:Pro-motivational agents 26773:Reliant Pharmaceuticals 26655: 26089:Phenylalkylpyrrolidines 26011:Methylenedioxycathinone 25688:3,4-MDA (tenamfetamine) 24427:Mepyramine (pyrilamine) 24108:3-Methoxydextrallorphan 23768:3-Methoxydextrallorphan 23591:Racemorphan (morphanol) 22853:Atypical antipsychotics 22462:Atypical antipsychotics 21780:Atypical antipsychotics 21213:Atypical antipsychotics 20515:Atypical antipsychotics 19768:Atypical antipsychotics 18147:Atypical antipsychotics 17753:Atypical antipsychotics 17365:Morphanol (racemorphan) 17305:Laudexium (laudolissin) 16715:Desformylflustrabromine 16151:mepyramine (pyrilamine) 12356:Atypical antipsychotics 11083:26 October 2020 at the 10633:(FDA). 3 October 2012. 9973:Am J Drug Alcohol Abuse 9653:Pharmacol Biochem Behav 9399:. Elsevier BV: 101014. 9324:10.1124/jpet.115.229765 8887:10.1023/a:1006986824213 8438:10.1023/a:1006986824213 8112:10.1124/jpet.114.222356 7776:Levenson M, Holland C. 7742:10.5114/pdia.2014.40930 7699:Prescrire International 7286:10.1136/jim-2020-001272 6656:Mayo Clinic Proceedings 6104:10.1001/jama.2020.23541 5907:10.1186/1471-2458-6-300 5382:10.1136/bmj-2021-067606 4004:10.1124/jpet.116.232876 3689:Diário Oficial da União 3530:Drug Metabolism Reviews 3436:List of antidepressants 3424:social anxiety disorder 3283:bupropion hydrochloride 3273:3'-chloro-propiophenone 2834:(DAT) by bupropion (300 1962:Exposure and half-life 1428:in various conditions. 1364:. The combination drug 1094:. Bupropion use during 1004:atypical antidepressant 150:Amfebutamone; 3-Chloro- 27496:Sigma receptor ligands 25013:β-Methylphenethylamine 25007:α-Methylphenethylamine 24482:Tiospirone (BMY-13859) 24422:Gevotroline (WY-47384) 24347:18-Methoxycoronaridine 24334:Allosteric modulators: 24093:Panamesine (EMD-57455) 24043:Siramesine (Lu 28-179) 23980:Ditolylguanidine (DTG) 23743:Allosteric modulators: 23706:Panamesine (EMD-57455) 23651:BMY-14802 (BMS-181100) 23443:Ditolylguanidine (DTG) 23423:Dextromethorphan (DXM) 23095:Typical antipsychotics 22666:Typical antipsychotics 21926:Typical antipsychotics 21808:Bemesetron (MDL-72222) 21528:Typical antipsychotics 20741:Typical antipsychotics 20163:Typical antipsychotics 18854:5-(nonyloxy)tryptamine 16425:Vanoxerine (GBR-12909) 16272:pethidine (meperidine) 15527:pethidine (meperidine) 14315:Pethidine (meperidine) 11368:J Clin Psychopharmacol 10769:Drug Safety Newsletter 10138:Depression and Anxiety 10020:10.1002/chir.530050704 8923:10.1124/mol.104.001313 8567:10.1124/mol.119.118349 8555:Molecular Pharmacology 8520:10.1124/mol.104.001313 8508:Molecular Pharmacology 6995:10.1186/1745-0179-2-24 6330:The Lancet. Psychiatry 6234:10.1542/peds.2019-2528 6145:10.1001/jama.2020.3332 3313: 3180:g/mol. It is a highly 3096:substituted cathinones 2967: 2924:, bupropion is not an 2912:values of 580 to 2,100 1740:(active metabolite of 1710:abnormal heart rhythms 1169: 1127:substituted cathinones 550:Erythrohydrobupropion: 27476:Nicotinic antagonists 27336:GlaxoSmithKline Prize 26763:Human Genome Sciences 26204:(and close relatives) 25703:MDMA (midomafetamine) 25045:-Methylphenethylamine 25037:-Methylphenethylamine 25029:-Methylphenethylamine 25021:-Methylphenethylamine 23753:Methylphenylpiracetam 23328:Alazocine (SKF-10047) 23244:Monoamine neurotoxins 21022:MDMA (midomafetamine) 20406:MDMA (midomafetamine) 20009:Opiranserin (VVZ-149) 19563:MDMA (midomafetamine) 19269:25H/NB series (e.g., 17570:Glycerophosphocholine 16509:Monoamine neurotoxins 16075:Dosulepin (dothiepin) 15622:Didesmethylcitalopram 15351:Dosulepin (dothiepin) 15028:Serdexmethylphenidate 14330:Serdexmethylphenidate 13817:Melanocortin agonists 13553:Absorption inhibitors 11251:Rossi S, ed. (2013). 10941:. 26 September 2019. 10465:"FDA approval letter" 9238:10.1002/ddr.430240107 9148:Fundam Clin Pharmacol 9098:Neurosci Biobehav Rev 8201:Clinical Therapeutics 7943:Clinical Therapeutics 7784:(FDA). Archived from 7204:J Head Trauma Rehabil 7087:10.2340/00015555-2702 6387:10.1089/cap.2016.0124 5035:"The Top 300 of 2022" 4311:10.1055/s-0043-117962 3925:. 17 September 2018. 3307: 2987:first-pass metabolism 2965: 1857:Bupropion lowers the 1610:liver transplantation 1418:motivational deficits 1167: 500:Erythrohydrobupropion 446:Hydroxybupropion: 77% 27511:Tert-butyl compounds 26733:Allen & Hanburys 26688:Stiefel Laboratories 26368:N,N-Dimethyldopamine 26026:Phenylisobutylamines 25723:Naphthylaminopropane 25408:Isopropylamphetamine 25398:4-Hydroxyamphetamine 23576:Pregnenolone sulfate 23388:Cutamesine (SA-4503) 21716:bufotenidine (5-HTQ) 20839:5-Methoxytryptamines 19353:5-Methoxytryptamines 17565:Dimethylethanolamine 17430:Rapacuronium bromide 17410:Pipecuronium bromide 17250:Gantacurium chloride 17210:Dizocilpine (MK-801) 16795:MEM-63,908 (RG-3487) 16745:Ethoxysebacylcholine 16400:Methoxytetrabenazine 16365:Dihydrotetrabenazine 16179:Arylcyclohexylamines 15474:Arylcyclohexylamines 14625:Dizocilpine (MK-801) 14579:Chaenomeles speciosa 14280:Benocyclidine (BTCP) 12477:Hypericum perforatum 12345:Adjunctive therapies 10708:. 24 December 1999. 9479:Inflammopharmacology 9393:Neuroscience Applied 9312:J Pharmacol Exp Ther 8743:J Pharmacol Exp Ther 8248:10.4088/jcp.v65n1113 7788:on 27 September 2007 6564:: 1745506518762664. 6521:10.4088/PCC.v06n0403 5656:10.4088/JCP.v69n0812 5483:10.1056/NEJMsa065779 5260:(10128): 1357–1366. 5008:. 30 December 1985. 4395:10.4088/jcp.v66n0215 4043:WHO Drug Information 3594:10.4088/pcc.v07n0305 3090:that belongs to the 2832:dopamine transporter 1805:area-under-the-curve 1608:leading to death or 1498:naltrexone/bupropion 1445:Naltrexone/bupropion 1366:naltrexone/bupropion 1121:that belongs to the 1105:Bupropion acts as a 1002:among others, is an 540:Threohydrobupropion: 281:(swallowed by mouth) 26530:Lysergic acid amide 26276:Ethylnorepinephrine 26079:Phenylisobutylamine 25531:Phenylpropanolamine 25466:-Norpseudoephedrine 25437:Levomethamphetamine 25324:Dimethylamphetamine 23726:Rimcazole (BW-234U) 22334:dihydroergocryptine 21018:MDA (tenamfetamine) 20402:MDA (tenamfetamine) 20367:dihydroergocryptine 19559:MDA (tenamfetamine) 17580:Phosphatidylcholine 17465:Threohydrobupropion 17450:Stercuronium iodide 17385:Pancuronium bromide 16024:Threohydrobupropion 15889:Desmethylsertraline 15617:Desmethylcitalopram 15300:Threohydrobupropion 15165:Desmethylsertraline 14820:Threohydrobupropion 14595:Desmethylsertraline 13325:Phenylpropanolamine 13204:Levopropylhexedrine 13176:Adrenergic agonists 13006:4-Methylamphetamine 12691:General anesthetics 12595:Nicotine dependence 11493:receptor modulators 11489:reuptake inhibitors 10816:on 20 December 2016 10782:on 11 February 2017 10478:. 6 December 2006. 10373:(5). Archived from 10313:on 25 February 2011 10285:2000JChEd..77.1479P 10193:(6 Pt 1): 955–956. 9703:Int Immunopharmacol 9569:Psychiatry Investig 8655:"Bupropion – PDSP K 7526:Clinical Cardiology 6697:Curr Neuropharmacol 6283:2020PLoSO..1540584E 5603:Clayton AH (2003). 5320:2020PLoSO..1529381H 4070:Sweetman S (2011). 3832:. 5 November 2019. 3380:Society and culture 2752:mechanism of action 2217: 1902: 1890:hypertensive crisis 1786:lopinavir/ritonavir 1630:in their children. 1621:open angle glaucoma 1187:quality of evidence 492:Threohydrobupropion 386:(Prescription only) 349:(Prescription only) 36: 27431:Anti-obesity drugs 27240:Silas M. Burroughs 26783:SmithKline Beecham 26748:Burroughs Wellcome 24986:Phenylethanolamine 23483:Igmesine (JO-1784) 23412:prasterone sulfate 23159:naphthylpiperazine 22930:2-Br-LSD (BOL-148) 22717:naphthylpiperazine 22695:2-Br-LSD (BOL-148) 22297:naphthylpiperazine 22204:2-Br-LSD (BOL-148) 21989:naphthylpiperazine 20865:α-Alkyltryptamines 19379:α-Alkyltryptamines 17663:Serotonin receptor 17500:Vecuronium bromide 17440:Rocuronium bromide 17350:Methyllycaconitine 17275:Hydroxynorketamine 17170:Dextropropoxyphene 17155:Dehydronorketamine 17145:Dacuronium bromide 16264:dextropropoxyphene 14290:Dexmethylphenidate 13934:methyltestosterone 13743:Sexual dysfunction 13699:Never to phase III 13624:Desiccated thyroid 13270:Dexmethylphenidate 12967:Antiobesity agents 12845:Opioid antagonists 12705:Opioid antagonists 12683:Hydrogen cyanamide 12650:Alcohol dependence 12537:Never to phase III 10841:The New York Times 10742:on 19 October 2010 10570:on 11 October 2013 10537:on 20 October 2012 10293:10.1021/ed077p1479 10187:Clinical Chemistry 8875:Cell Mol Neurobiol 8817:10.1007/BF02244985 7899:10.1007/BF03161207 7185:10.17863/CAM.40216 6874:10.1151/ascp084228 6429:10.1586/ern.11.137 5804:10.2147/copd.s1121 5753:10.3390/ph13060116 5609:Primary Psychiatry 4299:Pharmacopsychiatry 3314: 2968: 2351:47,000–>100,000 2215: 1900: 1550:alcohol withdrawal 1414:effort expenditure 1325:sexual dysfunction 1319:Sexual dysfunction 1181:of bupropion over 1170: 1146:Burroughs Wellcome 1072:excessive sweating 994:, formerly called 32: 27501:Smoking cessation 27451:CYP2D6 inhibitors 27416:5-HT3 antagonists 27376: 27375: 27273: 27272: 27145: 27144: 27019: 27018: 26719: 26718: 26623: 26622: 25964:N-Ethylpentedrone 25924:Dimethylcathinone 25546:Propylamphetamine 25289:Dextroamphetamine 24961:Methallylescaline 24509: 24508: 24344:Unknown/unsorted: 24105:Unknown/unsorted: 23840: 23765:Unknown/unsorted: 23428:Dextrorphan (DXO) 23254: 23253: 23247: 23238: 23229: 23216: 23207: 23198: 23189: 23172: 23171: 23168: 23167: 23138:Unknown/unsorted: 22946:dihydroergotamine 22726: 22725: 22688:Unknown/unsorted: 22338:dihydroergotamine 22306: 22305: 22276:Unknown/unsorted: 22176: 22175: 21998: 21997: 21977:Unknown/unsorted: 21646:ethanol (alcohol) 21596: 21595: 21592: 21591: 21567:Unknown/unsorted: 20958:dihydroergotamine 20785: 20784: 20769:Unknown/unsorted: 20371:dihydroergotamine 20268: 20267: 20255:dihydroergotamine 20248:Unknown/unsorted: 20077:hydroxynefazodone 19234: 19233: 19230: 19229: 19108: 19107: 19085:Unknown/unsorted: 18997: 18996: 18968:Unknown/unsorted: 18734:dihydroergotamine 18683: 18682: 18659:Unknown/unsorted: 18451:dihydroergotamine 18384: 18383: 18358:Unknown/unsorted: 18186:iodocyanopindolol 17874:dihydroergotamine 17727:hydroxynefazodone 17629: 17628: 17590:Phosphorylcholine 17528: 17513: 17512: 17310:Levacetylmethadol 17190:Dihydrochandonium 17070:sodium thiopental 16740:Ethanol (alcohol) 16517: 16516: 16512: 16298: 16297: 15573: 15548: 15547: 14993:Levophacetoperane 14863: 14838: 14837: 14700:Levophacetoperane 14275:4-Fluoropethidine 14210: 14149: 14148: 13938:anabolic steroids 13883:Nitrosoprodenafil 13754:Dopamine agonists 13746:pharmacotherapies 13709: 13708: 13598:2,4-Dinitrophenol 13531:receptor agonists 13426:glucagon agonists 13358: 13357: 13076:Dimethylcathinone 13071:Dextroamphetamine 12933: 12932: 12812:Levacetylmethadol 12760:Opioid dependence 12678:Calcium carbimide 12547: 12546: 12506: 12505: 12479:(St. John's Wort) 12430: 12429: 12395:lithium carbonate 12334: 12333: 12330: 12329: 12105: 12104: 12101: 12100: 11914:Amitriptylinoxide 11864: 11863: 11860: 11859: 11317:978-0-85711-156-2 11262:978-0-9805790-9-3 10441:. 8 August 2003. 10407:. 22 April 2005. 10111:978-3-88763-101-7 9873:978-0-12-420118-7 9761:978-0-07-162442-8 9192:(10): 1009–1028. 9046:Neuropharmacology 8604:Neuropharmacology 8388:10.1021/jm1003232 8382:(12): 4731–4748. 8242:(11): 1520–1524. 8160:10.1002/med.21671 7949:(11): 1685–1695. 7867:978-0-470-97969-3 7578:(12): 1704–1711. 7538:10.1002/clc.22744 6833:. 26 April 2019. 6703:(10): 1941–1955. 6423:(10): 1443–1465. 6138:(16): 1599–1608. 6005:10.1111/add.14134 5894:BMC Public Health 5785:Wilkes S (2008). 5126:(9665): 746–758. 4933:978-3-319-56449-4 4802:978-1-61537-331-4 4700:978-0-12-420118-7 4278:(Suppl 6): 9–15. 4081:978-0-85369-982-8 3785:. 21 April 2022. 3755:. 25 April 2012. 3723:. 25 April 2012. 3683:(31 March 2023). 3338:sustained-release 3297: 3296: 3250:hydrochloric acid 3248:and treated with 3162:molecular formula 3029:in the liver and 3015:-hydroxybupropion 2943:activity through 2937:anti-inflammatory 2830:The occupancy of 2797:-hydroxybupropion 2748: 2747: 2721:, β-adrenergic, D 2709:) were >10,000 2426:>10,000–81,000 2347:9,100–>100,000 2208: 2207: 1566:suicidal ideation 1534:seizure threshold 1524:Contraindications 1341:systematic review 1255:for nicotine and 1247:Smoking cessation 1012:smoking cessation 989: 988: 923:Interactive image 832:CompTox Dashboard 530:Hydroxybupropion: 409: 394: 381: 369: 357: 344: 260: 227: 27523: 27393: 27392: 27391: 27384: 27364: 27363: 27191:Patrick Vallance 27154: 27153: 26883:Wellbutrin/Zyban 26808: 26807: 26801: 26800: 26668: 26667: 26650: 26643: 26636: 26627: 26626: 26329: 26321: 26312: 26303: 26244: 26205: 25959:N-Ethylhexedrone 25939:Hydroxybupropion 25779:Chlorphentermine 25756: 25465: 25443:Methoxyphenamine 25418:Lisdexamfetamine 25362:Levofenfluramine 25002:Phenpromethamine 24536: 24529: 24522: 24513: 24512: 24199: 24195: 24154: 24150: 24144: 24140: 24013:(midomafetamine) 24012: 23862: 23858: 23852: 23848: 23838: 23506:(midomafetamine) 23505: 23374: 23370: 23281: 23274: 23267: 23258: 23257: 23241: 23232: 23226:releasing agents 23219: 23210: 23201: 23192: 23180: 22805:Serotonin (5-HT) 22740: 22739: 22373:Serotonin (5-HT) 22320: 22319: 22218:Serotonin (5-HT) 22190: 22189: 22097:Serotonin (5-HT) 22012: 22011: 21848:Hydroxybupropion 21689:Serotonin (5-HT) 21650:trichloroethanol 21628: 21627: 21616: 21615: 21121:Serotonin (5-HT) 20799: 20798: 20440:Serotonin (5-HT) 20322:levofenfluramine 20306:chlorphentermine 20292:4-Methylaminorex 20282: 20281: 20195:prochlorperazine 20019:Phenoxybenzamine 19989:MIN-117 (WF-516) 19644:Serotonin (5-HT) 19260: 19259: 19248: 19247: 19173:Serotonin (5-HT) 19122: 19121: 19036:Serotonin (5-HT) 19011: 19010: 18782:Serotonin (5-HT) 18697: 18696: 18483:Serotonin (5-HT) 18398: 18397: 18280:MIN-117 (WF-516) 18049:Serotonin (5-HT) 17694: 17693: 17682: 17681: 17656: 17649: 17642: 17633: 17632: 17522: 17460:Thiocolchicoside 17270:Hydroxybupropion 17165:Dextromethorphan 17037:Allopregnanolone 16991: 16987: 16890:Suberyldicholine 16600:6-Chloronicotine 16587: 16583: 16572: 16571: 16568: 16564: 16544: 16537: 16530: 16521: 16520: 16479: 16466:Antagonist-like: 16360:Deutetrabenazine 16310: 16306: 16250:MIN-117 (WF-516) 16215:Dextromethorphan 15587:6-Nitroquipazine 15577: 15576: 15571: 15567: 15562: 15560: 15556: 14983:Hydroxybupropion 14867: 14866: 14861: 14857: 14852: 14850: 14846: 14740:MIN-117 (WF-516) 14680:Hydroxybupropion 14620:Diphenylpyraline 14351:Diphenylprolinol 14214: 14213: 14208: 14204: 14199: 14197: 14193: 14176: 14169: 14162: 14153: 14152: 14081:Psychostimulants 13952:ethinylestradiol 13736: 13729: 13722: 13713: 13712: 13126:Lisdexamfetamine 13051:Chlorphentermine 12989: 12988: 12960: 12953: 12946: 12937: 12936: 12907:Chlordiazepoxide 12881: 12877: 12827:Dihydroetorphine 12775: 12771: 12735: 12731: 12661: 12635: 12631: 12574: 12567: 12560: 12551: 12550: 12487: 12453: 12436: 12435: 12409:triiodothyronine 12405:Thyroid hormones 12340: 12339: 12311: 12307: 12251: 12247: 12192:Phenoxypropazine 12124: 12123: 12111: 12110: 12055: 12051: 11897: 11893: 11887: 11886: 11870: 11869: 11749: 11745: 11716: 11712: 11683: 11679: 11650: 11646: 11617: 11613: 11569: 11565: 11511: 11507: 11501: 11500: 11483: 11482: 11463: 11456: 11449: 11440: 11439: 11433: 11432: 11422: 11398: 11392: 11391: 11363: 11357: 11356: 11328: 11322: 11321: 11303: 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Archived from 10586: 10580: 10579: 10577: 10575: 10566:. Archived from 10553: 10547: 10546: 10544: 10542: 10527: 10521: 10520: 10518: 10516: 10501: 10495: 10494: 10492: 10490: 10484: 10469: 10461: 10455: 10454: 10452: 10450: 10427: 10421: 10420: 10418: 10416: 10393: 10387: 10386: 10384: 10382: 10377:on 5 August 2007 10358: 10349: 10348: 10346: 10344: 10329: 10323: 10322: 10320: 10318: 10303: 10297: 10296: 10268: 10262: 10261: 10251: 10219: 10213: 10212: 10202: 10178: 10172: 10171: 10153: 10129: 10123: 10122: 10120: 10118: 10095: 10089: 10088: 10086: 10084: 10069: 10060: 10059: 10057: 10055: 10041: 10032: 10031: 10003: 9997: 9996: 9968: 9962: 9961: 9933: 9924: 9923: 9895: 9886: 9885: 9851: 9838: 9835: 9829: 9828: 9808: 9802: 9801: 9778:Pharmacogenetics 9772: 9766: 9765: 9745: 9739: 9738: 9736: 9734: 9694: 9685: 9684: 9648: 9639: 9638: 9609: 9603: 9602: 9592: 9560: 9554: 9553: 9528:(9): 2087–2093. 9517: 9511: 9510: 9485:(4): 1101–1109. 9474: 9468: 9467: 9457: 9433: 9427: 9426: 9408: 9384: 9375: 9374: 9342: 9336: 9335: 9307: 9301: 9300: 9290: 9280: 9256: 9250: 9249: 9220: 9214: 9213: 9181: 9172: 9171: 9143: 9132: 9131: 9121: 9089: 9078: 9077: 9041: 9035: 9034: 9024: 8992: 8986: 8985: 8957: 8944: 8941: 8935: 8934: 8905: 8899: 8898: 8870: 8864: 8863: 8846:(2–3): 249–258. 8835: 8829: 8828: 8800: 8794: 8793: 8776:(2–3): 115–121. 8765: 8759: 8758: 8738: 8732: 8731: 8729: 8727: 8713: 8704: 8703: 8701: 8699: 8684: 8675: 8674: 8672: 8670: 8647: 8638: 8637: 8627: 8595: 8589: 8588: 8578: 8546: 8540: 8539: 8502: 8493: 8492: 8464: 8458: 8457: 8421: 8410: 8409: 8399: 8367: 8352: 8351: 8332:10.1002/cpt.1888 8326:(5): 1036–1048. 8315: 8309: 8308: 8298: 8287:10.1002/cpt.1309 8281:(5): 1164–1174. 8266: 8260: 8259: 8231: 8225: 8224: 8207:(7): 1206–1227. 8196: 8190: 8189: 8171: 8154:(5): 1794–1832. 8142: 8133: 8132: 8114: 8090: 8084: 8083: 8073: 8049: 8043: 8042: 8040: 8038: 8032: 8021: 8013: 8002: 8001: 7973: 7967: 7966: 7938: 7921: 7920: 7910: 7878: 7872: 7871: 7853: 7847: 7846: 7836: 7804: 7798: 7797: 7795: 7793: 7773: 7764: 7763: 7753: 7721: 7715: 7714: 7694: 7688: 7687: 7677: 7645: 7639: 7638: 7602: 7596: 7595: 7566: 7560: 7559: 7549: 7517: 7511: 7510: 7474: 7468: 7467: 7465: 7463: 7415: 7409: 7408: 7371: 7365: 7364: 7362: 7360: 7341: 7335: 7334: 7332: 7330: 7315: 7298: 7297: 7280:(6): 1156–1158. 7269: 7263: 7262: 7234: 7228: 7227: 7199: 7193: 7192: 7170: 7159: 7158: 7148: 7116: 7110: 7109: 7099: 7089: 7065: 7059: 7058: 7048: 7039:(6): 1509–1522. 7024: 7018: 7017: 7007: 6997: 6973: 6967: 6966: 6937: 6931: 6930: 6902: 6896: 6895: 6885: 6853: 6847: 6846: 6844: 6842: 6823: 6817: 6816: 6814: 6812: 6789: 6783: 6782: 6772: 6748: 6739: 6738: 6720: 6688: 6682: 6681: 6671: 6647: 6641: 6640: 6630: 6598: 6592: 6591: 6581: 6549: 6543: 6542: 6532: 6500: 6494: 6493: 6457: 6451: 6450: 6440: 6408: 6399: 6398: 6370: 6364: 6363: 6353: 6321: 6315: 6314: 6304: 6294: 6277:(10): e0240584. 6262: 6256: 6255: 6245: 6228:(4): e20192528. 6213: 6207: 6206: 6196: 6164: 6158: 6157: 6147: 6123: 6117: 6116: 6106: 6082: 6076: 6075: 6065: 6033: 6027: 6026: 6016: 5984: 5978: 5977: 5941: 5930: 5929: 5919: 5909: 5885: 5879: 5878: 5868: 5836: 5827: 5826: 5816: 5806: 5782: 5776: 5775: 5765: 5755: 5731: 5725: 5724: 5706: 5682: 5676: 5675: 5650:(8): 1287–1292. 5638: 5629: 5628: 5626: 5624: 5600: 5594: 5593: 5583: 5551: 5545: 5544: 5534: 5502: 5496: 5495: 5485: 5461: 5455: 5454: 5444: 5434: 5410: 5404: 5403: 5393: 5361: 5352: 5351: 5341: 5331: 5299: 5288: 5287: 5277: 5245: 5234: 5233: 5231: 5229: 5223: 5200: 5174: 5165: 5152: 5151: 5114: 5108: 5107: 5105: 5086: 5080: 5079: 5077: 5075: 5061: 5055: 5054: 5052: 5050: 5031: 5025: 5024: 5022: 5020: 5014: 4999: 4991: 4982: 4981: 4979: 4977: 4961: 4950: 4949: 4947: 4945: 4917: 4908: 4907: 4905: 4903: 4884: 4875: 4874: 4838: 4827: 4826: 4824: 4822: 4784: 4773: 4772: 4762: 4745:(10): CD009504. 4730: 4713: 4712: 4678: 4665: 4664: 4662: 4660: 4654: 4615: 4606: 4591: 4590: 4588: 4586: 4538: 4529: 4528: 4518: 4494: 4485: 4484: 4456: 4445: 4444: 4416: 4407: 4406: 4377: 4368: 4367: 4366:on 17 July 2011. 4365: 4354: 4346: 4331: 4330: 4294: 4288: 4287: 4267: 4258: 4257: 4221: 4210: 4209: 4199: 4167: 4158: 4157: 4147: 4115: 4086: 4085: 4067: 4061: 4060: 4058: 4035: 4026: 4025: 4015: 3983: 3974: 3973: 3971: 3969: 3950: 3939: 3938: 3936: 3934: 3915: 3909: 3908: 3906: 3904: 3885: 3876: 3875: 3873: 3871: 3862:. 4 March 2022. 3852: 3846: 3845: 3843: 3841: 3822: 3799: 3798: 3796: 3794: 3775: 3769: 3768: 3766: 3764: 3743: 3737: 3736: 3734: 3732: 3711: 3705: 3704: 3702: 3700: 3677: 3671: 3670: 3668: 3666: 3651: 3645: 3644: 3642: 3640: 3630:nctr-crs.fda.gov 3622: 3616: 3615: 3605: 3573: 3562: 3561: 3525: 3476: 3475: 3473: 3471: 3452: 3385:Recreational use 3284: 3279: 3274: 3267: 3256: 3218:, among others. 3208:hydroxybupropion 3179: 3174:molecular weight 3086:Bupropion is an 3060:hydroxybupropion 3025:pathways are by 2996:pathways are by 2958:Pharmacokinetics 2941:pro-inflammatory 2915: 2911: 2907: 2849: 2837: 2772:hydroxybupropion 2736: 2732: 2712: 2685: 2681: 2660: 2638: 2612: 2582: 2552: 2522: 2492: 2448:6,600–>10,000 2422: 2396: 2349:1,000–>10,000 2344: 2340: 2293: 2289: 2242: 2238: 2218: 2214: 2211:Pharmacodynamics 1903: 1899: 1817:dextromethorphan 1722:hydroxybupropion 1651:suicidal thought 1538:anorexia nervosa 1519: 1515: 1507: 1503: 1491: 1487: 1482: 1478: 1474: 1271:but inferior to 1216:bipolar disorder 1151: 1144:, who worked at 985: 984: 925: 905: 893: 890: 887: 881: 875: 855: 854: 840: 838: 823: 803: 783: 775: 755: 735: 715: 695: 675: 665: 664: 638: 582: 578: 574: 557: 553: 547: 543: 537: 533: 527: 523: 516: 506: 498: 490: 484:Hydroxybupropion 482: 407: 404: 399: 392: 389: 379: 376: 368: 365: 355: 352: 342: 339: 317: 258: 255: 237: 226: 223: 210: 196: 128: 118: 111: 110: 107: 106: 103: 100: 97: 94: 91: 88: 85: 82: 79: 76: 53: 44: 37: 35: 31: 27531: 27530: 27526: 27525: 27524: 27522: 27521: 27520: 27426:Antidepressants 27401: 27400: 27399: 27389: 27387: 27379: 27377: 27372: 27352: 27319: 27269: 27223: 27219:Laurie Glimcher 27186:Manvinder Banga 27181:Roy M. Anderson 27176:Simon Dingemans 27158: 27141: 27015: 26898: 26792: 26725: 26715: 26703: 26698:ViiV Healthcare 26659: 26654: 26624: 26619: 26555:Methoxphenidine 26433: 26398:Normetanephrine 26327: 26319: 26310: 26301: 26242: 26203: 26202: 26194: 26083: 26074: 26020: 25981: 25832: 25823: 25811: 25762: 25754: 25730: 25578: 25566:Tranylcypromine 25551:Pseudoephedrine 25463: 25458:Norfenfluramine 25433:Methamphetamine 25358:Dexfenfluramine 25293:Levoamphetamine 25240: 25138:Bromo-DragonFLY 25086: 25072: 25050:Methylphenidate 24981: 24551:Phenethylamines 24545: 24543:Phenethylamines 24540: 24510: 24505: 24491: 24411:St. John's wort 24237:Ethylketazocine 24217: 24197: 24152: 24142: 24018:Methamphetamine 23949: 23940: 23926:Trifluoperazine 23860: 23850: 23526:Methylphenidate 23516:Methamphetamine 23372: 23302: 23293: 23285: 23255: 23250: 23164: 23129: 23107:chlorprothixene 22841: 22735: 22722: 22679: 22445: 22315: 22302: 22237: 22185: 22172: 22121: 22007: 21994: 21968: 21936:Volatiles/gases 21748: 21738:trichloroethane 21722:Volatiles/gases 21661:Phenylbiguanide 21623: 21612: 21605: 21588: 21558: 21191: 21061:Phenethylamines 20794: 20781: 20760: 20498: 20326:norfenfluramine 20314:dexfenfluramine 20277: 20264: 20239: 20219:trifluoperazine 19870:Chlorprothixene 19704: 19612:Phenethylamines 19423:Bromo-DragonFLY 19255: 19243: 19226: 19205: 19117: 19104: 19076: 19060: 19006: 18993: 18959: 18863: 18692: 18679: 18650: 18545: 18393: 18380: 18349: 18135: 17719:Antidepressants 17689: 17677: 17668: 17660: 17630: 17625: 17599: 17521: 17509: 17115:Chlorisondamine 16989: 16982: 16974: 16585: 16578: 16566: 16556: 16548: 16518: 16513: 16473: 16451:DAT modulators: 16429: 16330:methamphetamine 16308: 16294: 16205:Cyclobenzaprine 16147:diphenhydramine 16135:brompheniramine 16109: 16038: 15837: 15803:Levomilnacipran 15761: 15569: 15561: 15558: 15544: 15442:brompheniramine 15426: 15390: 15314: 15113: 15074:Levomilnacipran 15037: 15008:Methylphenidate 14951: 14859: 14851: 14848: 14834: 14521: 14375: 14339: 14310:Methylphenidate 14285:Desoxypipradrol 14263: 14206: 14198: 14195: 14185: 14180: 14150: 14145: 14127: 14093:methylphenidate 13986: 13912: 13893:Sulfoaildenafil 13845:PDE5 inhibitors 13839: 13811: 13748: 13740: 13710: 13705: 13704: 13689:Clinical trials 13668: 13602: 13584: 13548: 13530: 13523: 13500: 13424: 13408: 13365: 13354: 13335:Propylhexedrine 13310:Phendimetrazine 13305:Methylphenidate 13265:Dexfenfluramine 13228: 13170: 13141:Norfenfluramine 13136:Methamphetamine 12998:phenethylamines 12996: 12978: 12964: 12934: 12929: 12892:Benzodiazepines 12879: 12860: 12773: 12754: 12733: 12644: 12633: 12589: 12582:drug dependence 12578: 12548: 12543: 12542: 12527:Clinical trials 12502: 12441: 12426: 12422: 12414: 12399:lithium citrate 12347: 12326: 12309: 12306: 12296: 12249: 12246: 12236: 12212:Tranylcypromine 12118: 12097: 12081: 12053: 12043: 11895: 11881: 11856: 11765: 11747: 11737: 11714: 11704: 11681: 11671: 11648: 11638: 11615: 11605: 11586:Levomilnacipran 11567: 11557: 11509: 11495: 11477: 11470:Antidepressants 11467: 11437: 11436: 11407:Depress Anxiety 11399: 11395: 11364: 11360: 11329: 11325: 11318: 11304: 11300: 11290: 11288: 11275: 11274: 11270: 11263: 11249: 11245: 11232: 11230: 11217: 11216: 11212: 11173: 11169: 11138: 11134: 11095: 11091: 11085:Wayback Machine 11076: 11072: 11056:10.1.1.325.9635 11039: 11035: 10996: 10989: 10979: 10977: 10962: 10958: 10948: 10946: 10933: 10932: 10928: 10918: 10916: 10912: 10901: 10895: 10891: 10881: 10879: 10864: 10860: 10850: 10848: 10833: 10829: 10819: 10817: 10800: 10799: 10795: 10785: 10783: 10779: 10764: 10760: 10759: 10755: 10745: 10743: 10730: 10729: 10725: 10715: 10713: 10696: 10695: 10691: 10681: 10679: 10664: 10660: 10648: 10640: 10638: 10625: 10624: 10615: 10605: 10603: 10588: 10587: 10583: 10573: 10571: 10554: 10550: 10540: 10538: 10529: 10528: 10524: 10514: 10512: 10511:on 30 June 2007 10503: 10502: 10498: 10488: 10486: 10482: 10467: 10463: 10462: 10458: 10448: 10446: 10429: 10428: 10424: 10414: 10412: 10395: 10394: 10390: 10380: 10378: 10359: 10352: 10342: 10340: 10331: 10330: 10326: 10316: 10314: 10305: 10304: 10300: 10269: 10265: 10220: 10216: 10179: 10175: 10130: 10126: 10116: 10114: 10112: 10096: 10092: 10082: 10080: 10079:. 30 March 2009 10077:DrugBank Online 10071: 10070: 10063: 10053: 10051: 10043: 10042: 10035: 10004: 10000: 9969: 9965: 9934: 9927: 9896: 9889: 9874: 9852: 9841: 9836: 9832: 9809: 9805: 9773: 9769: 9762: 9746: 9742: 9732: 9730: 9695: 9688: 9649: 9642: 9615:Transplant Proc 9610: 9606: 9561: 9557: 9518: 9514: 9475: 9471: 9434: 9430: 9385: 9378: 9343: 9339: 9308: 9304: 9257: 9253: 9221: 9217: 9182: 9175: 9144: 9135: 9090: 9081: 9042: 9038: 8993: 8989: 8962:Ther Drug Monit 8958: 8947: 8942: 8938: 8906: 8902: 8871: 8867: 8840:Eur J Pharmacol 8836: 8832: 8801: 8797: 8770:Eur J Pharmacol 8766: 8762: 8739: 8735: 8725: 8723: 8715: 8714: 8707: 8697: 8695: 8685: 8678: 8668: 8666: 8658: 8648: 8641: 8610:(Pt A): 89–99. 8596: 8592: 8547: 8543: 8503: 8496: 8465: 8461: 8422: 8413: 8368: 8355: 8316: 8312: 8267: 8263: 8232: 8228: 8197: 8193: 8143: 8136: 8091: 8087: 8071:10.18433/J3H03R 8050: 8046: 8036: 8034: 8030: 8019: 8015: 8014: 8005: 7974: 7970: 7939: 7924: 7879: 7875: 7868: 7854: 7850: 7819:(20): 355–361. 7805: 7801: 7791: 7789: 7774: 7767: 7722: 7718: 7696: 7695: 7691: 7646: 7642: 7603: 7599: 7567: 7563: 7532:(10): 899–906. 7518: 7514: 7475: 7471: 7461: 7459: 7416: 7412: 7372: 7368: 7358: 7356: 7343: 7342: 7338: 7328: 7326: 7317: 7316: 7301: 7270: 7266: 7235: 7231: 7200: 7196: 7171: 7162: 7131:(1): CD001703. 7117: 7113: 7066: 7062: 7025: 7021: 6974: 6970: 6949:(10): 867–881. 6938: 6934: 6903: 6899: 6854: 6850: 6840: 6838: 6825: 6824: 6820: 6810: 6808: 6791: 6790: 6786: 6749: 6742: 6689: 6685: 6648: 6644: 6607:Sexual Medicine 6599: 6595: 6550: 6546: 6501: 6497: 6458: 6454: 6409: 6402: 6371: 6367: 6322: 6318: 6263: 6259: 6214: 6210: 6179:(3): CD010078. 6165: 6161: 6124: 6120: 6083: 6079: 6034: 6030: 5985: 5981: 5942: 5933: 5886: 5882: 5851:(5): CD000031. 5837: 5830: 5783: 5779: 5740:Pharmaceuticals 5732: 5728: 5683: 5679: 5639: 5632: 5622: 5620: 5601: 5597: 5552: 5548: 5517:(4): CD011268. 5503: 5499: 5462: 5458: 5425:(1): e1003886. 5411: 5407: 5362: 5355: 5314:(2): e0229381. 5300: 5291: 5246: 5237: 5227: 5225: 5221: 5172: 5166: 5155: 5115: 5111: 5087: 5083: 5073: 5071: 5063: 5062: 5058: 5048: 5046: 5033: 5032: 5028: 5018: 5016: 5012: 4997: 4993: 4992: 4985: 4975: 4973: 4962: 4953: 4943: 4941: 4934: 4918: 4911: 4901: 4899: 4886: 4885: 4878: 4839: 4830: 4820: 4818: 4803: 4785: 4776: 4731: 4716: 4701: 4679: 4668: 4658: 4656: 4652: 4613: 4607: 4594: 4584: 4582: 4539: 4532: 4495: 4488: 4457: 4448: 4417: 4410: 4378: 4371: 4363: 4357:GlaxoSmithKline 4352: 4348: 4347: 4334: 4295: 4291: 4268: 4261: 4222: 4213: 4182:(10): 913–917. 4168: 4161: 4116: 4089: 4082: 4068: 4064: 4036: 4029: 3984: 3977: 3967: 3965: 3952: 3951: 3942: 3932: 3930: 3917: 3916: 3912: 3902: 3900: 3895:. 2 June 2020. 3887: 3886: 3879: 3869: 3867: 3854: 3853: 3849: 3839: 3837: 3824: 3823: 3802: 3792: 3790: 3777: 3776: 3772: 3762: 3760: 3745: 3744: 3740: 3730: 3728: 3713: 3712: 3708: 3698: 3696: 3678: 3674: 3664: 3662: 3653: 3652: 3648: 3638: 3636: 3624: 3623: 3619: 3574: 3565: 3526: 3479: 3469: 3467: 3454: 3453: 3449: 3444: 3432: 3420: 3412: 3396: 3387: 3382: 3322:GlaxoSmithKline 3302: 3293: 3292: 3291: 3288: 3287: 3286: 3285: 3282: 3280: 3277: 3275: 3272: 3268: 3253: 3227: 3177: 3171: 3167: 3153:Bupropion is a 3144:optical isomers 3138:-bupropion and 3084: 3072:psychostimulant 3049:-hydrobupropion 3042:-hydrobupropion 2998:cytochrome P450 2983:bioavailability 2980: 2975: 2960: 2918:phenethylamines 2913: 2909: 2906: 2900:receptors with 2899: 2894: 2890: 2881: 2847: 2844:methylphenidate 2835: 2786:-hydrobupropion 2779:-hydrobupropion 2740: 2728: 2724: 2720: 2716: 2710: 2708: 2694: 2683: 2670: 2648: 2634: 2622: 2608: 2604: 2592: 2578: 2574: 2562: 2548: 2544: 2532: 2518: 2514: 2502: 2488: 2476: 2466: 2454: 2444: 2432: 2418: 2406: 2392: 2382: 2380: 2378: 2374: 2370: 2369: 2365: 2364: 2360: 2359: 2352: 2350: 2348: 2342: 2331: 2329: 2327: 2323: 2319: 2318: 2314: 2313: 2309: 2308: 2301: 2299: 2297: 2291: 2280: 2278: 2276: 2272: 2268: 2267: 2263: 2262: 2258: 2257: 2250: 2248: 2246: 2240: 2213: 2188: 2161: 2157: 2131: 2127: 2101: 2097: 2017: 1971: 1955: 1953: 1943: 1941: 1931: 1929: 1919: 1917: 1898: 1875:corticosteroids 1873:, and systemic 1718: 1686: 1643: 1580: 1574: 1542:bulimia nervosa 1526: 1517: 1513: 1505: 1501: 1489: 1485: 1480: 1476: 1472: 1451: 1441: 1439:Available forms 1426:clinical trials 1410:akinetic mutism 1378: 1353: 1321: 1313:methylphenidate 1301:onset of action 1285: 1249: 1175: 1162: 1149: 1040:adverse effects 1010:and to support 980: 978: 973: 970: 965: 960: 959: 948: 945: 940: 939: 928: 903: 884: 878: 858: 834: 826: 806: 786: 758: 738: 718: 698: 678: 661: 653: 645: 639: 621: 618: 605: 604: 584: 580: 576: 572: 555: 551: 549: 545: 541: 539: 535: 531: 529: 525: 521: 514: 504: 502: 496: 494: 488: 486: 480: 447: 445: 440:Protein binding 430:Bioavailability 422:Pharmacokinetic 416: 397: 321: 295:antidepressants 273: 266: 247: 240: 178:-butylcathinone 169: 159: 126: 122: 116: 112: 73: 69: 56: 28: 17: 12: 11: 5: 27529: 27519: 27518: 27513: 27508: 27503: 27498: 27493: 27488: 27483: 27478: 27473: 27468: 27466:Ergogenic aids 27463: 27458: 27453: 27448: 27443: 27438: 27433: 27428: 27423: 27418: 27413: 27398: 27397: 27374: 27373: 27371: 27370: 27357: 27354: 27353: 27351: 27350: 27345: 27338: 27333: 27327: 27325: 27321: 27320: 27318: 27317: 27310: 27303: 27296: 27289: 27281: 27279: 27275: 27274: 27271: 27270: 27268: 27267: 27262: 27257: 27255:Henry Wellcome 27252: 27247: 27242: 27237: 27235:Thomas Beecham 27231: 27229: 27225: 27224: 27222: 27221: 27216: 27211: 27206: 27203: 27201:Lynn Elsenhans 27198: 27193: 27188: 27183: 27178: 27173: 27168: 27166:Philip Hampton 27162: 27160: 27151: 27147: 27146: 27143: 27142: 27140: 27139: 27134: 27129: 27124: 27119: 27114: 27109: 27104: 27099: 27094: 27092:Goody's Powder 27089: 27084: 27081: 27076: 27071: 27066: 27061: 27056: 27051: 27046: 27041: 27036: 27033: 27027: 27025: 27021: 27020: 27017: 27016: 27014: 27013: 27002: 26997: 26992: 26987: 26982: 26977: 26972: 26967: 26962: 26957: 26952: 26947: 26942: 26937: 26932: 26927: 26922: 26917: 26912: 26906: 26904: 26900: 26899: 26897: 26896: 26885: 26880: 26875: 26870: 26865: 26860: 26855: 26850: 26845: 26840: 26835: 26830: 26825: 26820: 26814: 26812: 26805: 26798: 26794: 26793: 26791: 26790: 26785: 26780: 26775: 26770: 26765: 26760: 26758:Glaxo Wellcome 26755: 26750: 26745: 26740: 26735: 26729: 26727: 26721: 26720: 26717: 26716: 26711: 26709: 26705: 26704: 26702: 26701: 26695: 26690: 26685: 26680: 26674: 26672: 26665: 26661: 26660: 26653: 26652: 26645: 26638: 26630: 26621: 26620: 26618: 26617: 26612: 26607: 26602: 26597: 26592: 26589:Levosalbutamol 26582: 26577: 26572: 26567: 26562: 26557: 26552: 26547: 26542: 26537: 26532: 26527: 26522: 26517: 26512: 26507: 26502: 26497: 26492: 26487: 26482: 26477: 26472: 26470:Desvenlafaxine 26467: 26462: 26457: 26452: 26447: 26441: 26439: 26435: 26434: 26432: 26431: 26426: 26421: 26413: 26405: 26400: 26395: 26385: 26383:Norepinephrine 26380: 26370: 26365: 26360: 26355: 26350: 26345: 26340: 26332: 26324: 26322:-Phenylalanine 26316: 26307: 26298: 26293: 26288: 26283: 26278: 26273: 26268: 26263: 26258: 26253: 26248: 26239: 26234: 26229: 26224: 26219: 26214: 26208: 26206: 26200:Catecholamines 26196: 26195: 26193: 26192: 26187: 26182: 26177: 26172: 26167: 26162: 26157: 26152: 26147: 26142: 26137: 26132: 26127: 26122: 26117: 26112: 26107: 26102: 26093: 26091: 26085: 26084: 26082: 26081: 26069: 26064: 26059: 26054: 26049: 26044: 26039: 26030: 26028: 26022: 26021: 26019: 26018: 26013: 26008: 26003: 25998: 25993: 25988: 25976: 25971: 25966: 25961: 25956: 25951: 25946: 25941: 25936: 25931: 25926: 25921: 25916: 25911: 25906: 25901: 25896: 25891: 25886: 25881: 25876: 25871: 25866: 25861: 25856: 25851: 25842: 25840: 25834: 25833: 25831: 25830: 25818: 25806: 25801: 25796: 25791: 25786: 25781: 25772: 25770: 25764: 25763: 25761: 25760: 25747: 25742: 25737: 25725: 25720: 25715: 25713:Methamnetamine 25710: 25705: 25700: 25695: 25690: 25685: 25680: 25675: 25670: 25665: 25660: 25655: 25650: 25645: 25640: 25635: 25630: 25625: 25620: 25615: 25610: 25605: 25600: 25595: 25590: 25585: 25573: 25568: 25563: 25558: 25553: 25548: 25543: 25538: 25533: 25528: 25523: 25518: 25513: 25508: 25503: 25498: 25493: 25488: 25483: 25478: 25473: 25468: 25460: 25455: 25450: 25445: 25440: 25430: 25425: 25420: 25415: 25410: 25405: 25400: 25395: 25390: 25385: 25380: 25375: 25370: 25365: 25351: 25346: 25341: 25336: 25334:Etilamfetamine 25331: 25326: 25321: 25316: 25311: 25306: 25301: 25296: 25282: 25277: 25272: 25267: 25262: 25257: 25252: 25247: 25235: 25230: 25225: 25220: 25215: 25210: 25205: 25200: 25195: 25190: 25185: 25180: 25175: 25170: 25165: 25160: 25155: 25150: 25145: 25140: 25135: 25130: 25125: 25120: 25115: 25110: 25105: 25096: 25094: 25088: 25087: 25085: 25084: 25079: 25067: 25062: 25053: 25052: 25047: 25039: 25031: 25023: 25015: 25010: 25004: 24999: 24997:Phenethylamine 24994: 24979: 24978: 24973: 24968: 24963: 24958: 24953: 24948: 24943: 24938: 24933: 24928: 24923: 24918: 24912: 24911: 24906: 24901: 24896: 24891: 24886: 24881: 24876: 24871: 24866: 24861: 24856: 24851: 24846: 24841: 24836: 24831: 24826: 24821: 24816: 24811: 24806: 24801: 24796: 24791: 24786: 24781: 24776: 24771: 24766: 24761: 24756: 24751: 24746: 24741: 24736: 24731: 24726: 24721: 24716: 24711: 24706: 24701: 24696: 24691: 24686: 24681: 24676: 24671: 24666: 24661: 24656: 24651: 24646: 24641: 24636: 24631: 24626: 24621: 24616: 24611: 24606: 24601: 24596: 24591: 24585: 24584: 24579: 24574: 24569: 24564: 24555: 24553: 24547: 24546: 24539: 24538: 24531: 24524: 24516: 24507: 24506: 24496: 24493: 24492: 24490: 24489: 24484: 24479: 24474: 24469: 24464: 24459: 24454: 24449: 24444: 24439: 24434: 24429: 24424: 24419: 24414: 24404: 24399: 24394: 24389: 24384: 24379: 24377:Chlorpromazine 24374: 24369: 24364: 24359: 24354: 24349: 24340: 24339: 24330: 24329: 24324: 24319: 24314: 24309: 24304: 24299: 24294: 24289: 24284: 24279: 24274: 24265: 24264: 24259: 24254: 24249: 24244: 24239: 24234: 24225: 24223: 24219: 24218: 24216: 24215: 24210: 24205: 24200: 24190: 24185: 24180: 24175: 24170: 24165: 24160: 24155: 24145: 24135: 24130: 24125: 24120: 24115: 24110: 24101: 24100: 24095: 24090: 24085: 24080: 24075: 24070: 24065: 24060: 24051: 24050: 24045: 24040: 24035: 24030: 24025: 24020: 24015: 24007: 24002: 23997: 23992: 23987: 23982: 23977: 23972: 23967: 23962: 23953: 23951: 23947: 23942: 23941: 23939: 23938: 23933: 23928: 23923: 23918: 23913: 23908: 23903: 23898: 23893: 23888: 23883: 23878: 23873: 23868: 23863: 23853: 23843: 23835: 23830: 23825: 23820: 23818:Chlorpromazine 23815: 23810: 23805: 23800: 23795: 23790: 23785: 23780: 23775: 23770: 23761: 23760: 23755: 23739: 23738: 23733: 23728: 23723: 23718: 23713: 23708: 23703: 23698: 23693: 23688: 23683: 23678: 23673: 23671:E-52862 (S1RA) 23668: 23663: 23658: 23653: 23648: 23643: 23638: 23633: 23628: 23623: 23618: 23613: 23604: 23603: 23598: 23593: 23588: 23583: 23578: 23573: 23568: 23563: 23558: 23553: 23548: 23543: 23538: 23536:Neuropeptide Y 23533: 23528: 23523: 23518: 23513: 23508: 23500: 23495: 23490: 23485: 23480: 23475: 23470: 23465: 23460: 23455: 23450: 23445: 23440: 23435: 23430: 23425: 23420: 23418:Dextrallorphan 23415: 23405: 23395: 23390: 23385: 23380: 23375: 23365: 23360: 23355: 23350: 23345: 23340: 23335: 23330: 23325: 23320: 23315: 23306: 23304: 23300: 23295: 23294: 23288:Sigma receptor 23284: 23283: 23276: 23269: 23261: 23252: 23251: 23249: 23248: 23239: 23230: 23217: 23208: 23199: 23190: 23177: 23174: 23173: 23170: 23169: 23166: 23165: 23163: 23162: 23152: 23134: 23131: 23130: 23128: 23127: 23122: 23103:chlorpromazine 23099:acetophenazine 23092: 23074: 23052: 23047: 23042: 23037: 23032: 23027: 23022: 23017: 23012: 23007: 23002: 22997: 22992: 22987: 22982: 22977: 22923: 22918: 22913: 22908: 22846: 22843: 22842: 22840: 22839: 22817: 22807: 22802: 22797: 22792: 22787: 22782: 22777: 22767: 22762: 22757: 22752: 22743: 22737: 22733: 22728: 22727: 22724: 22723: 22721: 22720: 22710: 22684: 22681: 22680: 22678: 22677: 22670:chlorpromazine 22663: 22641: 22627: 22622: 22617: 22612: 22607: 22602: 22597: 22592: 22587: 22582: 22577: 22572: 22567: 22562: 22557: 22552: 22547: 22542: 22537: 22532: 22527: 22522: 22517: 22512: 22507: 22502: 22497: 22459: 22450: 22447: 22446: 22444: 22443: 22438: 22433: 22375: 22370: 22365: 22323: 22317: 22313: 22308: 22307: 22304: 22303: 22301: 22300: 22290: 22272: 22271: 22266: 22261: 22256: 22251: 22242: 22239: 22238: 22236: 22235: 22233:Valerenic acid 22230: 22220: 22215: 22193: 22187: 22183: 22178: 22177: 22174: 22173: 22171: 22170: 22165: 22160: 22155: 22150: 22145: 22140: 22135: 22126: 22123: 22122: 22120: 22119: 22114: 22109: 22104: 22099: 22094: 22089: 22084: 22079: 22074: 22069: 22064: 22059: 22057:Metoclopramide 22054: 22049: 22044: 22039: 22034: 22029: 22024: 22015: 22009: 22005: 22000: 21999: 21996: 21995: 21993: 21992: 21982: 21973: 21970: 21969: 21967: 21966: 21961: 21956: 21951: 21933: 21923: 21918: 21913: 21908: 21890: 21885: 21880: 21875: 21870: 21865: 21860: 21855: 21850: 21845: 21840: 21835: 21830: 21825: 21820: 21815: 21810: 21805: 21800: 21795: 21777: 21772: 21767: 21762: 21753: 21750: 21749: 21747: 21746: 21741: 21719: 21701: 21696: 21691: 21686: 21681: 21663: 21658: 21653: 21631: 21625: 21621: 21613: 21607: 21603: 21598: 21597: 21594: 21593: 21590: 21589: 21587: 21586: 21572: 21563: 21560: 21559: 21557: 21556: 21551: 21532:chlorpromazine 21525: 21511: 21506: 21501: 21496: 21466: 21461: 21456: 21451: 21446: 21441: 21436: 21431: 21426: 21421: 21416: 21411: 21406: 21401: 21396: 21391: 21386: 21381: 21376: 21371: 21366: 21361: 21356: 21351: 21346: 21308: 21303: 21298: 21293: 21288: 21286:Cyproheptadine 21283: 21278: 21273: 21268: 21210: 21205: 21196: 21193: 21192: 21190: 21189: 21184: 21179: 21174: 21169: 21123: 21118: 21113: 21108: 21103: 21098: 21072: 21058: 21053: 21048: 21043: 21038: 21033: 21011: 21006: 21001: 20943: 20921: 20916: 20911: 20906: 20901: 20896: 20862: 20836: 20802: 20796: 20792: 20787: 20786: 20783: 20782: 20780: 20779: 20765: 20762: 20761: 20759: 20758: 20753: 20748: 20745:chlorpromazine 20738: 20733: 20715: 20710: 20705: 20700: 20695: 20690: 20685: 20680: 20675: 20670: 20665: 20660: 20655: 20650: 20645: 20640: 20635: 20630: 20625: 20620: 20615: 20610: 20580: 20575: 20573:Cyproheptadine 20570: 20512: 20503: 20500: 20499: 20497: 20496: 20442: 20437: 20432: 20427: 20417: 20395: 20390: 20356: 20334: 20329: 20299: 20294: 20285: 20279: 20275: 20270: 20269: 20266: 20265: 20263: 20262: 20244: 20241: 20240: 20238: 20237: 20232: 20227: 20222: 20167:chlorpromazine 20160: 20150: 20120: 20115: 20110: 20105: 20100: 20066: 20061: 20056: 20051: 20046: 20041: 20036: 20031: 20026: 20021: 20016: 20011: 20006: 20001: 19996: 19991: 19986: 19981: 19976: 19971: 19966: 19961: 19956: 19951: 19946: 19941: 19936: 19931: 19897: 19892: 19887: 19882: 19877: 19872: 19867: 19765: 19760: 19745:cyproheptadine 19741:Antihistamines 19738: 19733: 19728: 19723: 19718: 19709: 19706: 19705: 19703: 19702: 19656: 19651: 19646: 19641: 19623: 19609: 19607:SCHEMBL5334361 19604: 19599: 19594: 19589: 19584: 19579: 19574: 19552: 19547: 19542: 19537: 19532: 19462: 19457: 19435: 19430: 19425: 19420: 19415: 19410: 19376: 19350: 19345: 19340: 19310: 19263: 19257: 19253: 19245: 19241: 19236: 19235: 19232: 19231: 19228: 19227: 19225: 19224: 19219: 19210: 19207: 19206: 19204: 19203: 19193: 19175: 19170: 19165: 19160: 19139: 19134: 19125: 19119: 19115: 19110: 19109: 19106: 19105: 19103: 19102: 19081: 19078: 19077: 19075: 19074: 19065: 19062: 19061: 19059: 19058: 19048: 19038: 19033: 19023: 19014: 19008: 19004: 18999: 18998: 18995: 18994: 18992: 18991: 18973: 18964: 18961: 18960: 18958: 18957: 18952: 18947: 18942: 18937: 18932: 18927: 18922: 18917: 18912: 18907: 18902: 18897: 18887: 18882: 18877: 18868: 18865: 18864: 18862: 18861: 18831: 18789: 18784: 18779: 18774: 18769: 18764: 18759: 18754: 18749: 18719: 18714: 18709: 18700: 18694: 18690: 18685: 18684: 18681: 18680: 18678: 18677: 18655: 18652: 18651: 18649: 18648: 18643: 18638: 18633: 18628: 18623: 18618: 18613: 18608: 18598: 18593: 18559: 18550: 18547: 18546: 18544: 18543: 18538: 18516: 18511: 18485: 18480: 18475: 18470: 18440: 18435: 18430: 18425: 18420: 18415: 18410: 18401: 18395: 18391: 18386: 18385: 18382: 18381: 18379: 18378: 18368: 18363: 18354: 18351: 18350: 18348: 18347: 18342: 18337: 18332: 18327: 18322: 18317: 18312: 18307: 18302: 18297: 18292: 18287: 18282: 18277: 18272: 18267: 18262: 18257: 18252: 18247: 18242: 18232: 18227: 18222: 18217: 18167: 18162: 18140: 18137: 18136: 18134: 18133: 18128: 18123: 18118: 18113: 18108: 18103: 18061: 18056: 18051: 18046: 18041: 18036: 18031: 18026: 18021: 18016: 18011: 18006: 18001: 17996: 17991: 17986: 17981: 17976: 17971: 17966: 17961: 17956: 17951: 17946: 17941: 17936: 17931: 17926: 17921: 17916: 17911: 17906: 17901: 17859: 17854: 17849: 17844: 17839: 17834: 17829: 17824: 17819: 17814: 17788: 17750: 17716: 17711: 17706: 17697: 17691: 17687: 17679: 17675: 17670: 17669: 17659: 17658: 17651: 17644: 17636: 17627: 17626: 17624: 17623: 17618: 17613: 17608: 17604: 17601: 17600: 17598: 17597: 17592: 17587: 17582: 17577: 17572: 17567: 17562: 17557: 17552: 17542: 17537: 17531: 17529: 17515: 17514: 17511: 17510: 17508: 17507: 17502: 17497: 17492: 17487: 17482: 17477: 17472: 17467: 17462: 17457: 17452: 17447: 17442: 17437: 17432: 17427: 17422: 17417: 17412: 17407: 17402: 17397: 17392: 17387: 17382: 17377: 17372: 17367: 17362: 17357: 17352: 17347: 17342: 17337: 17332: 17327: 17322: 17317: 17312: 17307: 17302: 17297: 17295:Kynurenic acid 17292: 17287: 17282: 17277: 17272: 17267: 17262: 17257: 17252: 17247: 17242: 17237: 17232: 17227: 17222: 17217: 17212: 17207: 17202: 17197: 17192: 17187: 17182: 17177: 17172: 17167: 17162: 17157: 17152: 17147: 17142: 17137: 17132: 17127: 17122: 17117: 17112: 17107: 17102: 17097: 17092: 17089:κ-bungarotoxin 17085:α-bungarotoxin 17078: 17073: 17059: 17054: 17049: 17044: 17039: 17034: 17029: 17024: 17023:, many others) 17013:α-bungarotoxin 17006: 17001: 16995: 16993: 16976: 16975: 16973: 16972: 16967: 16962: 16957: 16952: 16947: 16945:Tribendimidine 16942: 16937: 16932: 16927: 16922: 16917: 16912: 16907: 16902: 16897: 16892: 16887: 16882: 16877: 16872: 16870:Sebacylcholine 16867: 16862: 16857: 16852: 16847: 16842: 16837: 16832: 16827: 16822: 16817: 16812: 16802: 16797: 16792: 16787: 16782: 16777: 16772: 16767: 16762: 16757: 16752: 16747: 16742: 16737: 16732: 16727: 16722: 16717: 16712: 16707: 16702: 16697: 16692: 16687: 16685:Butyrylcholine 16682: 16677: 16672: 16667: 16662: 16657: 16652: 16647: 16642: 16637: 16632: 16627: 16622: 16617: 16612: 16607: 16602: 16597: 16591: 16589: 16569: 16558: 16557: 16547: 16546: 16539: 16532: 16524: 16515: 16514: 16478: 16475: 16474: 16472: 16471: 16459: 16447: 16446: 16441:DAT enhancers: 16437: 16435: 16431: 16430: 16428: 16427: 16422: 16417: 16412: 16407: 16402: 16397: 16392: 16387: 16382: 16377: 16372: 16367: 16362: 16357: 16352: 16347: 16342: 16337: 16319: 16313: 16311: 16300: 16299: 16296: 16295: 16293: 16292: 16287: 16257: 16252: 16247: 16242: 16237: 16232: 16227: 16222: 16217: 16212: 16207: 16202: 16176: 16165:Antipsychotics 16162: 16159:tripelennamine 16143:dimenhydrinate 16139:chlorphenamine 16131:Antihistamines 16128: 16123: 16114: 16111: 16110: 16108: 16107: 16102: 16097: 16092: 16087: 16082: 16077: 16072: 16067: 16065:Cyanodothiepin 16062: 16057: 16052: 16043: 16040: 16039: 16037: 16036: 16026: 16021: 16016: 16011: 16006: 16001: 15996: 15991: 15986: 15981: 15976: 15971: 15966: 15961: 15956: 15951: 15946: 15941: 15936: 15931: 15926: 15921: 15916: 15911: 15906: 15901: 15896: 15891: 15886: 15881: 15876: 15871: 15866: 15861: 15856: 15851: 15842: 15839: 15838: 15836: 15835: 15830: 15825: 15820: 15815: 15810: 15805: 15800: 15795: 15790: 15788:Desvenlafaxine 15785: 15780: 15775: 15766: 15763: 15762: 15760: 15759: 15754: 15749: 15744: 15739: 15734: 15729: 15724: 15719: 15714: 15705: 15704: 15699: 15694: 15689: 15684: 15679: 15674: 15669: 15664: 15659: 15654: 15649: 15644: 15639: 15634: 15629: 15624: 15619: 15614: 15609: 15604: 15599: 15594: 15589: 15580: 15574: 15550: 15549: 15546: 15545: 15543: 15542: 15512: 15507: 15502: 15495: 15490: 15485: 15471: 15460:Antipsychotics 15457: 15454:tripelennamine 15446:chlorphenamine 15438:Antihistamines 15431: 15428: 15427: 15425: 15424: 15419: 15414: 15409: 15404: 15395: 15392: 15391: 15389: 15388: 15383: 15378: 15373: 15368: 15363: 15358: 15353: 15348: 15343: 15338: 15333: 15328: 15319: 15316: 15315: 15313: 15312: 15302: 15297: 15292: 15287: 15282: 15277: 15272: 15267: 15262: 15257: 15252: 15247: 15242: 15237: 15232: 15227: 15222: 15217: 15212: 15207: 15202: 15197: 15192: 15187: 15182: 15177: 15172: 15167: 15162: 15157: 15152: 15147: 15142: 15137: 15132: 15127: 15118: 15115: 15114: 15112: 15111: 15106: 15101: 15096: 15091: 15086: 15081: 15076: 15071: 15066: 15061: 15059:Desvenlafaxine 15056: 15051: 15042: 15039: 15038: 15036: 15035: 15030: 15025: 15020: 15015: 15010: 15005: 15000: 14995: 14990: 14985: 14980: 14975: 14970: 14965: 14956: 14953: 14952: 14950: 14949: 14944: 14939: 14934: 14929: 14924: 14919: 14914: 14909: 14904: 14899: 14894: 14889: 14884: 14879: 14870: 14864: 14840: 14839: 14836: 14835: 14833: 14832: 14827: 14825:Tripelennamine 14822: 14817: 14812: 14807: 14802: 14797: 14792: 14787: 14782: 14777: 14772: 14767: 14762: 14757: 14752: 14747: 14742: 14737: 14732: 14727: 14722: 14717: 14712: 14707: 14702: 14697: 14692: 14687: 14682: 14677: 14672: 14667: 14662: 14657: 14652: 14647: 14642: 14637: 14632: 14627: 14622: 14617: 14612: 14607: 14602: 14597: 14592: 14587: 14582: 14575: 14570: 14565: 14560: 14555: 14550: 14548:Amfonelic acid 14545: 14540: 14535: 14526: 14523: 14522: 14520: 14519: 14514: 14509: 14504: 14499: 14494: 14489: 14484: 14479: 14474: 14469: 14464: 14459: 14454: 14449: 14444: 14439: 14434: 14429: 14424: 14419: 14414: 14409: 14404: 14399: 14394: 14389: 14380: 14377: 14376: 14374: 14373: 14368: 14363: 14358: 14353: 14344: 14341: 14340: 14338: 14337: 14332: 14327: 14322: 14317: 14312: 14307: 14302: 14300:Ethylphenidate 14297: 14292: 14287: 14282: 14277: 14268: 14265: 14264: 14262: 14261: 14256: 14251: 14246: 14241: 14236: 14231: 14226: 14217: 14211: 14187: 14186: 14179: 14178: 14171: 14164: 14156: 14147: 14146: 14144: 14143: 14132: 14129: 14128: 14126: 14125: 14113: 14108: 14096: 14078: 14073: 14068: 14063: 14058: 14053: 14048: 14043: 14041:Cyproheptadine 14038: 14033: 14028: 14023: 14018: 14016:Alkyl nitrites 14013: 13994: 13992: 13988: 13987: 13985: 13984: 13977: 13963: 13941: 13922: 13920: 13914: 13913: 13911: 13910: 13905: 13900: 13895: 13890: 13885: 13880: 13875: 13870: 13865: 13860: 13855: 13849: 13847: 13841: 13840: 13838: 13837: 13832: 13827: 13821: 13819: 13813: 13812: 13810: 13809: 13804: 13799: 13794: 13789: 13784: 13779: 13774: 13769: 13764: 13758: 13756: 13750: 13749: 13739: 13738: 13731: 13724: 13716: 13707: 13706: 13703: 13702: 13701: 13700: 13697: 13686: 13680: 13674: 13673: 13670: 13669: 13667: 13666: 13661: 13656: 13651: 13646: 13641: 13636: 13631: 13626: 13621: 13616: 13610: 13608: 13604: 13603: 13601: 13600: 13594: 13592: 13586: 13585: 13583: 13582: 13577: 13572: 13567: 13562: 13556: 13554: 13550: 13549: 13547: 13546: 13541: 13535: 13533: 13525: 13524: 13522: 13521: 13510: 13508: 13502: 13501: 13499: 13498: 13492: 13482: 13477: 13472: 13467: 13462: 13456: 13451: 13446: 13441: 13436: 13430: 13428: 13410: 13409: 13407: 13406: 13401: 13396: 13391: 13386: 13381: 13376: 13370: 13368: 13360: 13359: 13356: 13355: 13353: 13352: 13347: 13342: 13337: 13332: 13327: 13322: 13317: 13315:Phenethylamine 13312: 13307: 13302: 13297: 13292: 13282: 13277: 13272: 13267: 13262: 13252: 13247: 13242: 13236: 13234: 13230: 13229: 13227: 13226: 13216: 13211: 13206: 13201: 13196: 13191: 13186: 13180: 13178: 13172: 13171: 13169: 13168: 13163: 13158: 13148: 13143: 13138: 13133: 13128: 13123: 13118: 13113: 13108: 13103: 13098: 13093: 13091:Etilamfetamine 13088: 13083: 13078: 13073: 13068: 13063: 13058: 13053: 13048: 13043: 13038: 13033: 13028: 13023: 13018: 13013: 13008: 13002: 13000: 12986: 12980: 12979: 12963: 12962: 12955: 12948: 12940: 12931: 12930: 12928: 12927: 12915: 12909: 12904: 12899: 12888: 12870: 12868: 12862: 12861: 12859: 12858: 12852: 12841: 12840: 12839: 12834: 12829: 12824: 12822:Dihydrocodeine 12819: 12814: 12809: 12792: 12787: 12781: 12764: 12762: 12756: 12755: 12753: 12752: 12747: 12742: 12725: 12720: 12719: 12718: 12713: 12701: 12700: 12699: 12687: 12686: 12685: 12680: 12675: 12670: 12654: 12652: 12646: 12645: 12643: 12642: 12625: 12620: 12615: 12610: 12605: 12599: 12597: 12591: 12590: 12577: 12576: 12569: 12562: 12554: 12545: 12544: 12541: 12540: 12539: 12538: 12535: 12524: 12518: 12512: 12511: 12508: 12507: 12504: 12503: 12501: 12500: 12495: 12490: 12481: 12473: 12456: 12450:Ademetionine ( 12446: 12443: 12442: 12432: 12431: 12428: 12427: 12425: 12424: 12420: 12412: 12402: 12388: 12383: 12352: 12349: 12348: 12336: 12335: 12332: 12331: 12328: 12327: 12325: 12324: 12315: 12313: 12304: 12298: 12297: 12295: 12294: 12289: 12284: 12279: 12274: 12269: 12264: 12255: 12253: 12244: 12238: 12237: 12235: 12234: 12225: 12224: 12215: 12214: 12209: 12204: 12199: 12194: 12189: 12184: 12179: 12174: 12169: 12164: 12159: 12154: 12149: 12144: 12139: 12130: 12128: 12120: 12119: 12107: 12106: 12103: 12102: 12099: 12098: 12096: 12095: 12089: 12087: 12083: 12082: 12080: 12079: 12074: 12069: 12064: 12058: 12056: 12045: 12044: 12042: 12041: 12036: 12031: 12026: 12021: 12016: 12011: 12006: 12001: 11996: 11991: 11986: 11981: 11976: 11971: 11969:Imipraminoxide 11966: 11961: 11956: 11951: 11946: 11941: 11936: 11931: 11926: 11921: 11916: 11911: 11906: 11900: 11898: 11883: 11882: 11866: 11865: 11862: 11861: 11858: 11857: 11855: 11854: 11849: 11844: 11839: 11834: 11829: 11824: 11819: 11814: 11809: 11804: 11799: 11794: 11789: 11784: 11779: 11773: 11771: 11767: 11766: 11764: 11763: 11758: 11752: 11750: 11739: 11738: 11736: 11735: 11730: 11725: 11719: 11717: 11706: 11705: 11703: 11702: 11697: 11692: 11686: 11684: 11673: 11672: 11670: 11669: 11664: 11659: 11653: 11651: 11640: 11639: 11637: 11636: 11631: 11626: 11620: 11618: 11607: 11606: 11604: 11603: 11598: 11593: 11588: 11583: 11578: 11576:Desvenlafaxine 11572: 11570: 11559: 11558: 11556: 11555: 11550: 11545: 11540: 11535: 11530: 11525: 11520: 11514: 11512: 11497: 11496: 11479: 11478: 11466: 11465: 11458: 11451: 11443: 11435: 11434: 11413:(2): 111–113. 11393: 11374:(4): 276–277. 11358: 11339:(4): 615–625. 11323: 11316: 11298: 11268: 11261: 11243: 11221:(in Russian). 11210: 11183:(5): 357–362. 11167: 11148:(3): 216–217. 11132: 11089: 11070: 11033: 11006:(4): 341–354. 10987: 10956: 10926: 10889: 10858: 10827: 10793: 10753: 10723: 10689: 10658: 10613: 10602:on 6 June 2011 10581: 10548: 10522: 10496: 10456: 10422: 10388: 10350: 10324: 10298: 10263: 10234:(2): 105–108. 10214: 10173: 10124: 10110: 10090: 10061: 10033: 10014:(7): 495–500. 9998: 9979:(4): 341–354. 9963: 9944:(3): 287–298. 9925: 9906:(3): 293–313. 9900:Drug Metab Rev 9887: 9872: 9839: 9830: 9819:(4): 637–643. 9803: 9784:(4): 225–238. 9767: 9760: 9740: 9686: 9640: 9604: 9555: 9512: 9469: 9428: 9376: 9337: 9318:(1): 134–144. 9302: 9265:Front Neurosci 9251: 9215: 9173: 9154:(4): 387–394. 9133: 9079: 9052:(6): 820–830. 9036: 9007:(1): 260–266. 8987: 8968:(2): 155–169. 8945: 8936: 8917:(3): 675–682. 8900: 8881:(4): 467–489. 8865: 8830: 8811:(4): 559–565. 8795: 8760: 8733: 8705: 8676: 8656: 8639: 8590: 8561:(3): 171–179. 8541: 8514:(3): 675–682. 8494: 8459: 8432:(4): 467–489. 8411: 8353: 8310: 8261: 8226: 8191: 8134: 8105:(1): 102–111. 8085: 8064:(2): 198–207. 8044: 8003: 7984:(5): 327–333. 7968: 7922: 7893:(4): 238–250. 7873: 7866: 7848: 7799: 7765: 7716: 7689: 7640: 7597: 7561: 7512: 7469: 7430:(3): 296–303. 7410: 7366: 7336: 7299: 7274:J Investig Med 7264: 7245:(2): 181–188. 7229: 7194: 7160: 7111: 7080:(8): 897–905. 7060: 7019: 6968: 6932: 6897: 6848: 6818: 6784: 6763:(7): 532–546. 6740: 6683: 6662:(1): 114–128. 6642: 6593: 6558:Women's Health 6544: 6515:(4): 159–166. 6495: 6468:(3): 259–266. 6452: 6400: 6381:(2): 112–116. 6365: 6336:(9): 727–738. 6316: 6257: 6208: 6159: 6118: 6097:(3): 280–298. 6077: 6028: 5999:(5): 805–816. 5979: 5952:(7): 965–981. 5931: 5880: 5828: 5777: 5726: 5697:(5): 545–546. 5677: 5630: 5619:on 4 June 2020 5595: 5546: 5497: 5456: 5405: 5353: 5289: 5235: 5153: 5109: 5081: 5056: 5026: 4983: 4951: 4932: 4909: 4876: 4849:(4): 481–488. 4828: 4801: 4774: 4714: 4699: 4666: 4624:(8): 561–628. 4592: 4553:(3): 291–312. 4530: 4509:(5): 438–450. 4486: 4467:(6): 612–617. 4446: 4427:(4): 404–415. 4408: 4389:(2): 253–259. 4369: 4332: 4305:(4): 121–135. 4289: 4259: 4232:(5): 653–689. 4211: 4159: 4087: 4080: 4062: 4027: 3998:(2): 230–238. 3975: 3940: 3910: 3877: 3847: 3800: 3770: 3738: 3706: 3672: 3646: 3617: 3588:(3): 106–113. 3563: 3536:(3): 293–313. 3477: 3446: 3445: 3443: 3440: 3439: 3438: 3431: 3428: 3419: 3416: 3411: 3408: 3395: 3392: 3386: 3383: 3381: 3378: 3355:Sanofi-Aventis 3308:Comparison of 3301: 3298: 3295: 3294: 3289: 3270: 3269: 3262: 3261: 3260: 3259: 3226: 3223: 3169: 3165: 3155:small-molecule 3083: 3080: 2978: 2973: 2959: 2956: 2904: 2897: 2892: 2888: 2879: 2746: 2745: 2738: 2726: 2722: 2718: 2714: 2706: 2699: 2698: 2695: 2692: 2689: 2686: 2675: 2674: 2671: 2668: 2665: 2662: 2653: 2652: 2649: 2646: 2643: 2640: 2632: 2627: 2626: 2623: 2620: 2617: 2614: 2606: 2602: 2597: 2596: 2593: 2590: 2587: 2584: 2576: 2572: 2567: 2566: 2563: 2560: 2557: 2554: 2546: 2542: 2537: 2536: 2533: 2530: 2527: 2524: 2516: 2512: 2507: 2506: 2503: 2500: 2497: 2494: 2486: 2481: 2480: 2477: 2474: 2471: 2468: 2464: 2459: 2458: 2455: 2452: 2449: 2446: 2442: 2437: 2436: 2433: 2430: 2427: 2424: 2416: 2411: 2410: 2407: 2404: 2401: 2398: 2390: 2385: 2384: 2375: 2372: 2367: 2362: 2357: 2354: 2345: 2334: 2333: 2324: 2321: 2316: 2311: 2306: 2303: 2294: 2283: 2282: 2273: 2270: 2265: 2260: 2255: 2252: 2243: 2232: 2231: 2228: 2225: 2222: 2212: 2209: 2206: 2205: 2202: 2199: 2196: 2193: 2190: 2186: 2181: 2180: 2177: 2174: 2171: 2168: 2165: 2159: 2155: 2150: 2149: 2146: 2143: 2140: 2137: 2134: 2129: 2125: 2120: 2119: 2116: 2113: 2110: 2107: 2104: 2099: 2095: 2090: 2089: 2086: 2083: 2080: 2077: 2074: 2067: 2066: 2063: 2060: 2057: 2054: 2051: 2044: 2043: 2040: 2037: 2034: 2031: 2028: 2021: 2020: 2015: 2009: 2008: 2005: 2002: 1999: 1996: 1993: 1989: 1988: 1985: 1982: 1979: 1976: 1973: 1964: 1963: 1959: 1958: 1946: 1934: 1922: 1910: 1907: 1897: 1894: 1863:antipsychotics 1778:St John's wort 1724:by the enzyme 1717: 1714: 1685: 1682: 1642: 1639: 1606:liver toxicity 1585:desvenlafaxine 1573: 1570: 1558:kidney disease 1546:benzodiazepine 1525: 1522: 1440: 1437: 1377: 1374: 1352: 1349: 1320: 1317: 1284: 1281: 1248: 1245: 1174: 1171: 1161: 1158: 1090:, and risk of 1084:liver toxicity 1076:blood pressure 987: 986: 975: 974: 972: 971: 968: 966: 963: 955: 954: 953: 950: 949: 947: 946: 943: 935: 934: 933: 930: 929: 927: 926: 918: 916: 908: 907: 901: 895: 894: 882: 876: 871: 865: 864: 860: 859: 857: 856: 843: 841: 828: 827: 825: 824: 816: 814: 808: 807: 805: 804: 796: 794: 788: 787: 785: 784: 776: 768: 766: 760: 759: 757: 756: 748: 746: 740: 739: 737: 736: 728: 726: 720: 719: 717: 716: 708: 706: 700: 699: 697: 696: 688: 686: 680: 679: 677: 676: 668: 666: 655: 654: 652: 651: 631: 629: 623: 622: 620: 619: 608: 600: 599: 598: 595: 594: 590: 589: 566: 560: 559: 518: 509: 508: 477: 471: 470: 456: 450: 449: 444:Bupropion: 84% 442: 436: 435: 432: 426: 425: 418: 417: 415: 414: 411: 402: 387: 374: 363: 350: 336: 334: 328: 327: 323: 322: 320: 319: 306: 304: 298: 297: 289: 283: 282: 276: 274:administration 268: 267: 265: 264: 262: 252: 250: 242: 241: 239: 238: 220: 218: 212: 211: 204: 198: 197: 190: 180: 179: 148: 144: 143: 140: 134: 133: 67: 63: 62: 58: 57: 54: 46: 45: 15: 9: 6: 4: 3: 2: 27528: 27517: 27514: 27512: 27509: 27507: 27504: 27502: 27499: 27497: 27494: 27492: 27489: 27487: 27484: 27482: 27479: 27477: 27474: 27472: 27469: 27467: 27464: 27462: 27459: 27457: 27454: 27452: 27449: 27447: 27444: 27442: 27439: 27437: 27434: 27432: 27429: 27427: 27424: 27422: 27419: 27417: 27414: 27412: 27409: 27408: 27406: 27396: 27386: 27385: 27382: 27369: 27368: 27359: 27358: 27355: 27349: 27346: 27344: 27343: 27339: 27337: 27334: 27332: 27329: 27328: 27326: 27322: 27316: 27315: 27311: 27309: 27308: 27304: 27302: 27301: 27297: 27295: 27294: 27290: 27288: 27287: 27283: 27282: 27280: 27276: 27266: 27263: 27261: 27258: 27256: 27253: 27251: 27250:John K. Smith 27248: 27246: 27243: 27241: 27238: 27236: 27233: 27232: 27230: 27226: 27220: 27217: 27215: 27212: 27210: 27207: 27205:Jesse Goodman 27204: 27202: 27199: 27197: 27194: 27192: 27189: 27187: 27184: 27182: 27179: 27177: 27174: 27172: 27171:Emma Walmsley 27169: 27167: 27164: 27163: 27161: 27155: 27152: 27148: 27138: 27135: 27133: 27130: 27128: 27125: 27123: 27120: 27118: 27115: 27113: 27110: 27108: 27105: 27103: 27100: 27098: 27095: 27093: 27090: 27088: 27085: 27082: 27080: 27077: 27075: 27072: 27070: 27067: 27065: 27062: 27060: 27057: 27055: 27052: 27050: 27047: 27045: 27042: 27040: 27037: 27034: 27032: 27029: 27028: 27026: 27022: 27012: 27011: 27006: 27003: 27001: 26998: 26996: 26993: 26991: 26988: 26986: 26983: 26981: 26978: 26976: 26973: 26971: 26968: 26966: 26963: 26961: 26958: 26956: 26953: 26951: 26948: 26946: 26943: 26941: 26938: 26936: 26933: 26931: 26928: 26926: 26923: 26921: 26918: 26916: 26913: 26911: 26908: 26907: 26905: 26901: 26895: 26894: 26889: 26886: 26884: 26881: 26879: 26876: 26874: 26871: 26869: 26866: 26864: 26863:Paxil/Seroxat 26861: 26859: 26856: 26854: 26851: 26849: 26846: 26844: 26841: 26839: 26836: 26834: 26831: 26829: 26826: 26824: 26821: 26819: 26816: 26815: 26813: 26809: 26806: 26802: 26799: 26795: 26789: 26786: 26784: 26781: 26779: 26776: 26774: 26771: 26769: 26766: 26764: 26761: 26759: 26756: 26754: 26751: 26749: 26746: 26744: 26741: 26739: 26738:Beecham Group 26736: 26734: 26731: 26730: 26728: 26724:Predecessors, 26722: 26714: 26710: 26706: 26699: 26696: 26694: 26691: 26689: 26686: 26684: 26681: 26679: 26676: 26675: 26673: 26669: 26666: 26662: 26658: 26651: 26646: 26644: 26639: 26637: 26632: 26631: 26628: 26616: 26613: 26611: 26608: 26606: 26605:Thiamphenicol 26603: 26601: 26600:Theodrenaline 26598: 26596: 26593: 26590: 26586: 26583: 26581: 26578: 26576: 26573: 26571: 26568: 26566: 26563: 26561: 26558: 26556: 26553: 26551: 26548: 26546: 26543: 26541: 26538: 26536: 26533: 26531: 26528: 26526: 26523: 26521: 26518: 26516: 26515:Fluorolintane 26513: 26511: 26508: 26506: 26503: 26501: 26498: 26496: 26493: 26491: 26488: 26486: 26483: 26481: 26478: 26476: 26473: 26471: 26468: 26466: 26463: 26461: 26458: 26456: 26453: 26451: 26448: 26446: 26443: 26442: 26440: 26438:Miscellaneous 26436: 26430: 26427: 26425: 26424:Phenylephrine 26422: 26420: 26418: 26414: 26412: 26410: 26406: 26404: 26403:Orciprenaline 26401: 26399: 26396: 26393: 26389: 26386: 26384: 26381: 26378: 26377:Levonordefrin 26374: 26371: 26369: 26366: 26364: 26361: 26359: 26356: 26354: 26351: 26349: 26346: 26344: 26341: 26339: 26337: 26333: 26331: 26325: 26323: 26317: 26314: 26308: 26305: 26299: 26297: 26294: 26292: 26289: 26287: 26284: 26282: 26279: 26277: 26274: 26272: 26269: 26267: 26264: 26262: 26259: 26257: 26254: 26252: 26249: 26246: 26240: 26238: 26235: 26233: 26230: 26228: 26225: 26223: 26220: 26218: 26215: 26213: 26210: 26209: 26207: 26201: 26197: 26191: 26188: 26186: 26183: 26181: 26178: 26176: 26173: 26171: 26168: 26166: 26163: 26161: 26158: 26156: 26153: 26151: 26148: 26146: 26143: 26141: 26138: 26136: 26133: 26131: 26128: 26126: 26123: 26121: 26118: 26116: 26113: 26111: 26108: 26106: 26103: 26101: 26098: 26095: 26094: 26092: 26090: 26086: 26080: 26077: 26073: 26070: 26068: 26065: 26063: 26060: 26058: 26055: 26053: 26050: 26048: 26045: 26043: 26040: 26038: 26035: 26032: 26031: 26029: 26027: 26023: 26017: 26014: 26012: 26009: 26007: 26004: 26002: 25999: 25997: 25994: 25992: 25989: 25987: 25984: 25980: 25977: 25975: 25972: 25970: 25967: 25965: 25962: 25960: 25957: 25955: 25952: 25950: 25947: 25945: 25944:Methcathinone 25942: 25940: 25937: 25935: 25932: 25930: 25927: 25925: 25922: 25920: 25917: 25915: 25912: 25910: 25907: 25905: 25902: 25900: 25897: 25895: 25892: 25890: 25887: 25885: 25882: 25880: 25877: 25875: 25872: 25870: 25867: 25865: 25862: 25860: 25857: 25855: 25852: 25850: 25847: 25844: 25843: 25841: 25839: 25835: 25829: 25826: 25822: 25819: 25817: 25814: 25810: 25807: 25805: 25802: 25800: 25799:Mephentermine 25797: 25795: 25792: 25790: 25787: 25785: 25782: 25780: 25777: 25774: 25773: 25771: 25769: 25765: 25758: 25751: 25748: 25746: 25743: 25741: 25738: 25736: 25733: 25729: 25726: 25724: 25721: 25719: 25716: 25714: 25711: 25709: 25706: 25704: 25701: 25699: 25696: 25694: 25691: 25689: 25686: 25684: 25681: 25679: 25676: 25674: 25671: 25669: 25666: 25664: 25661: 25659: 25656: 25654: 25651: 25649: 25648:6-Chloro-MDMA 25646: 25644: 25641: 25639: 25636: 25634: 25631: 25629: 25626: 25624: 25621: 25619: 25616: 25614: 25611: 25609: 25606: 25604: 25601: 25599: 25596: 25594: 25591: 25589: 25586: 25584: 25581: 25577: 25574: 25572: 25571:Xylopropamine 25569: 25567: 25564: 25562: 25559: 25557: 25554: 25552: 25549: 25547: 25544: 25542: 25539: 25537: 25534: 25532: 25529: 25527: 25524: 25522: 25519: 25517: 25514: 25512: 25509: 25507: 25504: 25502: 25499: 25497: 25494: 25492: 25489: 25487: 25484: 25482: 25479: 25477: 25474: 25472: 25469: 25467: 25461: 25459: 25456: 25454: 25451: 25449: 25446: 25444: 25441: 25438: 25434: 25431: 25429: 25426: 25424: 25421: 25419: 25416: 25414: 25411: 25409: 25406: 25404: 25401: 25399: 25396: 25394: 25391: 25389: 25386: 25384: 25381: 25379: 25376: 25374: 25371: 25369: 25366: 25363: 25359: 25355: 25352: 25350: 25347: 25345: 25342: 25340: 25337: 25335: 25332: 25330: 25327: 25325: 25322: 25320: 25317: 25315: 25312: 25310: 25309:Benzphetamine 25307: 25305: 25302: 25300: 25297: 25294: 25290: 25286: 25283: 25281: 25278: 25276: 25273: 25271: 25268: 25266: 25263: 25261: 25258: 25256: 25253: 25251: 25248: 25246: 25243: 25239: 25236: 25234: 25231: 25229: 25226: 25224: 25221: 25219: 25216: 25214: 25211: 25209: 25206: 25204: 25201: 25199: 25196: 25194: 25191: 25189: 25186: 25184: 25181: 25179: 25176: 25174: 25171: 25169: 25166: 25164: 25161: 25159: 25156: 25154: 25151: 25149: 25146: 25144: 25141: 25139: 25136: 25134: 25131: 25129: 25126: 25124: 25121: 25119: 25116: 25114: 25111: 25109: 25106: 25104: 25101: 25100:Psychedelics: 25098: 25097: 25095: 25093: 25089: 25083: 25080: 25078: 25075: 25071: 25068: 25066: 25063: 25061: 25058: 25055: 25054: 25051: 25048: 25046: 25044: 25040: 25038: 25036: 25032: 25030: 25028: 25024: 25022: 25020: 25016: 25014: 25011: 25009:(amphetamine) 25008: 25005: 25003: 25000: 24998: 24995: 24993: 24990: 24989: 24988: 24987: 24984: 24977: 24974: 24972: 24969: 24967: 24964: 24962: 24959: 24957: 24954: 24952: 24949: 24947: 24944: 24942: 24939: 24937: 24934: 24932: 24931:Isoproscaline 24929: 24927: 24924: 24922: 24919: 24917: 24916:Allylescaline 24914: 24913: 24910: 24907: 24905: 24902: 24900: 24897: 24895: 24892: 24890: 24887: 24885: 24882: 24880: 24877: 24875: 24872: 24870: 24867: 24865: 24862: 24860: 24857: 24855: 24852: 24850: 24847: 24845: 24842: 24840: 24837: 24835: 24832: 24830: 24827: 24825: 24822: 24820: 24817: 24815: 24812: 24810: 24807: 24805: 24802: 24800: 24797: 24795: 24792: 24790: 24787: 24785: 24782: 24780: 24777: 24775: 24772: 24770: 24767: 24765: 24762: 24760: 24757: 24755: 24752: 24750: 24747: 24745: 24742: 24740: 24737: 24735: 24732: 24730: 24727: 24725: 24722: 24720: 24717: 24715: 24712: 24710: 24707: 24705: 24702: 24700: 24697: 24695: 24692: 24690: 24687: 24685: 24682: 24680: 24677: 24675: 24672: 24670: 24667: 24665: 24662: 24660: 24657: 24655: 24652: 24650: 24647: 24645: 24642: 24640: 24637: 24635: 24632: 24630: 24627: 24625: 24622: 24620: 24617: 24615: 24612: 24610: 24607: 24605: 24602: 24600: 24597: 24595: 24592: 24590: 24587: 24586: 24583: 24580: 24578: 24575: 24573: 24570: 24568: 24565: 24563: 24560: 24559:Psychedelics: 24557: 24556: 24554: 24552: 24548: 24544: 24537: 24532: 24530: 24525: 24523: 24518: 24517: 24514: 24504: 24503: 24500: 24494: 24488: 24485: 24483: 24480: 24478: 24475: 24473: 24470: 24468: 24465: 24463: 24460: 24458: 24455: 24453: 24450: 24448: 24445: 24443: 24440: 24438: 24435: 24433: 24430: 24428: 24425: 24423: 24420: 24418: 24415: 24412: 24408: 24405: 24403: 24400: 24398: 24395: 24393: 24390: 24388: 24385: 24383: 24380: 24378: 24375: 24373: 24370: 24368: 24365: 24363: 24360: 24358: 24355: 24353: 24350: 24348: 24345: 24342: 24341: 24338: 24335: 24332: 24331: 24328: 24325: 24323: 24320: 24318: 24315: 24313: 24310: 24308: 24305: 24303: 24300: 24298: 24295: 24293: 24290: 24288: 24285: 24283: 24280: 24278: 24275: 24273: 24270: 24267: 24266: 24263: 24262:Tenocyclidine 24260: 24258: 24255: 24253: 24250: 24248: 24245: 24243: 24240: 24238: 24235: 24233: 24230: 24227: 24226: 24224: 24220: 24214: 24211: 24209: 24206: 24204: 24201: 24196: 24191: 24189: 24186: 24184: 24181: 24179: 24176: 24174: 24171: 24169: 24166: 24164: 24161: 24159: 24156: 24151: 24146: 24141: 24136: 24134: 24131: 24129: 24126: 24124: 24121: 24119: 24116: 24114: 24111: 24109: 24106: 24103: 24102: 24099: 24096: 24094: 24091: 24089: 24086: 24084: 24081: 24079: 24076: 24074: 24071: 24069: 24066: 24064: 24061: 24059: 24056: 24053: 24052: 24049: 24046: 24044: 24041: 24039: 24038:Phencyclidine 24036: 24034: 24031: 24029: 24026: 24024: 24021: 24019: 24016: 24014: 24008: 24006: 24003: 24001: 23998: 23996: 23993: 23991: 23988: 23986: 23983: 23981: 23978: 23976: 23973: 23971: 23968: 23966: 23963: 23961: 23958: 23955: 23954: 23952: 23950: 23943: 23937: 23934: 23932: 23929: 23927: 23924: 23922: 23919: 23917: 23914: 23912: 23909: 23907: 23904: 23902: 23899: 23897: 23894: 23892: 23889: 23887: 23884: 23882: 23879: 23877: 23874: 23872: 23869: 23867: 23864: 23859: 23854: 23849: 23844: 23842: 23836: 23834: 23831: 23829: 23826: 23824: 23821: 23819: 23816: 23814: 23811: 23809: 23808:Amitriptyline 23806: 23804: 23801: 23799: 23796: 23794: 23791: 23789: 23786: 23784: 23781: 23779: 23776: 23774: 23771: 23769: 23766: 23763: 23762: 23759: 23756: 23754: 23751: 23747: 23744: 23741: 23740: 23737: 23734: 23732: 23729: 23727: 23724: 23722: 23719: 23717: 23714: 23712: 23709: 23707: 23704: 23702: 23699: 23697: 23694: 23692: 23689: 23687: 23684: 23682: 23679: 23677: 23674: 23672: 23669: 23667: 23664: 23662: 23659: 23657: 23654: 23652: 23649: 23647: 23644: 23642: 23639: 23637: 23634: 23632: 23629: 23627: 23624: 23622: 23619: 23617: 23614: 23612: 23609: 23606: 23605: 23602: 23599: 23597: 23594: 23592: 23589: 23587: 23584: 23582: 23579: 23577: 23574: 23572: 23569: 23567: 23564: 23562: 23559: 23557: 23554: 23552: 23549: 23547: 23544: 23542: 23539: 23537: 23534: 23532: 23529: 23527: 23524: 23522: 23521:Methoxetamine 23519: 23517: 23514: 23512: 23509: 23507: 23501: 23499: 23496: 23494: 23491: 23489: 23486: 23484: 23481: 23479: 23476: 23474: 23471: 23469: 23466: 23464: 23461: 23459: 23456: 23454: 23451: 23449: 23446: 23444: 23441: 23439: 23436: 23434: 23431: 23429: 23426: 23424: 23421: 23419: 23416: 23413: 23409: 23406: 23403: 23399: 23396: 23394: 23391: 23389: 23386: 23384: 23381: 23379: 23376: 23371: 23366: 23364: 23361: 23359: 23356: 23354: 23351: 23349: 23346: 23344: 23341: 23339: 23336: 23334: 23331: 23329: 23326: 23324: 23321: 23319: 23316: 23314: 23311: 23308: 23307: 23305: 23303: 23296: 23292: 23289: 23282: 23277: 23275: 23270: 23268: 23263: 23262: 23259: 23246: 23245: 23240: 23237: 23236: 23231: 23228: 23227: 23223: 23218: 23215: 23214: 23213:Melatonergics 23209: 23206: 23205: 23204:Dopaminergics 23200: 23197: 23196: 23191: 23188: 23187: 23184: 23179: 23178: 23175: 23160: 23156: 23153: 23150: 23146: 23142: 23139: 23136: 23135: 23132: 23126: 23123: 23120: 23116: 23112: 23108: 23104: 23100: 23096: 23093: 23090: 23086: 23082: 23081:amitriptyline 23078: 23075: 23072: 23068: 23064: 23060: 23056: 23053: 23051: 23048: 23046: 23043: 23041: 23038: 23036: 23033: 23031: 23028: 23026: 23023: 23021: 23018: 23016: 23013: 23011: 23008: 23006: 23003: 23001: 22998: 22996: 22993: 22991: 22988: 22986: 22983: 22981: 22978: 22975: 22971: 22967: 22963: 22959: 22955: 22951: 22947: 22943: 22939: 22938:bromocriptine 22935: 22931: 22927: 22924: 22922: 22919: 22917: 22914: 22912: 22909: 22906: 22902: 22898: 22894: 22890: 22886: 22882: 22878: 22874: 22870: 22869:brexpiprazole 22866: 22862: 22858: 22854: 22851: 22848: 22847: 22844: 22837: 22833: 22829: 22825: 22821: 22818: 22815: 22811: 22808: 22806: 22803: 22801: 22798: 22796: 22793: 22791: 22788: 22786: 22783: 22781: 22778: 22775: 22771: 22768: 22766: 22763: 22761: 22758: 22756: 22753: 22751: 22748: 22745: 22744: 22741: 22738: 22736: 22729: 22718: 22714: 22711: 22708: 22704: 22700: 22699:bromocriptine 22696: 22692: 22689: 22686: 22685: 22682: 22675: 22671: 22667: 22664: 22661: 22660:nortriptyline 22657: 22653: 22649: 22648:amitriptyline 22645: 22642: 22639: 22635: 22631: 22628: 22626: 22623: 22621: 22618: 22616: 22613: 22611: 22608: 22606: 22603: 22601: 22598: 22596: 22593: 22591: 22588: 22586: 22583: 22581: 22578: 22576: 22573: 22571: 22568: 22566: 22563: 22561: 22558: 22556: 22553: 22551: 22548: 22546: 22543: 22541: 22538: 22536: 22533: 22531: 22528: 22526: 22523: 22521: 22518: 22516: 22513: 22511: 22508: 22506: 22503: 22501: 22498: 22495: 22491: 22487: 22483: 22479: 22475: 22471: 22467: 22463: 22460: 22458: 22455: 22452: 22451: 22448: 22442: 22439: 22437: 22434: 22431: 22427: 22423: 22419: 22415: 22411: 22407: 22403: 22399: 22395: 22391: 22387: 22383: 22379: 22376: 22374: 22371: 22369: 22366: 22363: 22359: 22355: 22351: 22347: 22343: 22339: 22335: 22331: 22328: 22325: 22324: 22321: 22318: 22316: 22309: 22298: 22294: 22291: 22288: 22284: 22280: 22277: 22274: 22273: 22270: 22267: 22265: 22262: 22260: 22257: 22255: 22252: 22250: 22247: 22244: 22243: 22240: 22234: 22231: 22228: 22224: 22221: 22219: 22216: 22213: 22209: 22205: 22201: 22198: 22195: 22194: 22191: 22188: 22186: 22179: 22169: 22166: 22164: 22161: 22159: 22156: 22154: 22151: 22149: 22146: 22144: 22141: 22139: 22136: 22134: 22131: 22128: 22127: 22124: 22118: 22115: 22113: 22110: 22108: 22105: 22103: 22100: 22098: 22095: 22093: 22090: 22088: 22085: 22083: 22080: 22078: 22075: 22073: 22070: 22068: 22065: 22063: 22060: 22058: 22055: 22053: 22050: 22048: 22045: 22043: 22040: 22038: 22035: 22033: 22030: 22028: 22025: 22023: 22020: 22017: 22016: 22013: 22010: 22008: 22001: 21990: 21986: 21983: 21981: 21978: 21975: 21974: 21971: 21965: 21962: 21960: 21957: 21955: 21952: 21949: 21945: 21941: 21940:nitrous oxide 21937: 21934: 21931: 21927: 21924: 21922: 21919: 21917: 21914: 21912: 21909: 21906: 21902: 21898: 21894: 21891: 21889: 21888:Tedatioxetine 21886: 21884: 21881: 21879: 21876: 21874: 21871: 21869: 21866: 21864: 21861: 21859: 21856: 21854: 21851: 21849: 21846: 21844: 21841: 21839: 21838:Galanolactone 21836: 21834: 21831: 21829: 21826: 21824: 21821: 21819: 21816: 21814: 21811: 21809: 21806: 21804: 21801: 21799: 21796: 21793: 21789: 21785: 21781: 21778: 21776: 21773: 21771: 21768: 21766: 21763: 21761: 21758: 21755: 21754: 21751: 21745: 21742: 21739: 21735: 21731: 21727: 21723: 21720: 21717: 21713: 21709: 21705: 21702: 21700: 21697: 21695: 21692: 21690: 21687: 21685: 21682: 21679: 21675: 21671: 21667: 21664: 21662: 21659: 21657: 21654: 21651: 21647: 21643: 21639: 21636: 21633: 21632: 21629: 21626: 21624: 21617: 21614: 21611: 21606: 21599: 21584: 21580: 21576: 21573: 21571: 21568: 21565: 21564: 21561: 21555: 21552: 21549: 21545: 21541: 21537: 21533: 21529: 21526: 21523: 21522:nortriptyline 21519: 21518:amitriptyline 21515: 21512: 21510: 21507: 21505: 21502: 21500: 21497: 21494: 21490: 21486: 21482: 21481:esmirtazapine 21478: 21474: 21470: 21467: 21465: 21464:Tedatioxetine 21462: 21460: 21457: 21455: 21452: 21450: 21447: 21445: 21442: 21440: 21437: 21435: 21432: 21430: 21427: 21425: 21422: 21420: 21417: 21415: 21412: 21410: 21407: 21405: 21402: 21400: 21397: 21395: 21392: 21390: 21387: 21385: 21382: 21380: 21377: 21375: 21372: 21370: 21367: 21365: 21362: 21360: 21357: 21355: 21352: 21350: 21347: 21344: 21340: 21336: 21332: 21328: 21324: 21320: 21319:bromocriptine 21316: 21312: 21309: 21307: 21304: 21302: 21299: 21297: 21296:Desmetramadol 21294: 21292: 21289: 21287: 21284: 21282: 21279: 21277: 21274: 21272: 21269: 21266: 21262: 21258: 21254: 21250: 21246: 21242: 21238: 21234: 21230: 21226: 21222: 21218: 21214: 21211: 21209: 21206: 21204: 21201: 21198: 21197: 21194: 21188: 21185: 21183: 21180: 21178: 21175: 21173: 21170: 21167: 21163: 21159: 21155: 21151: 21147: 21143: 21139: 21135: 21131: 21127: 21124: 21122: 21119: 21117: 21114: 21112: 21109: 21107: 21104: 21102: 21099: 21096: 21092: 21088: 21084: 21080: 21076: 21073: 21070: 21066: 21062: 21059: 21057: 21054: 21052: 21049: 21047: 21044: 21042: 21039: 21037: 21034: 21031: 21027: 21023: 21019: 21015: 21012: 21010: 21007: 21005: 21002: 20999: 20995: 20991: 20987: 20983: 20979: 20975: 20971: 20967: 20963: 20959: 20955: 20951: 20947: 20944: 20941: 20937: 20933: 20929: 20925: 20922: 20920: 20917: 20915: 20912: 20910: 20907: 20905: 20902: 20900: 20897: 20894: 20890: 20886: 20882: 20878: 20874: 20870: 20866: 20863: 20860: 20856: 20852: 20848: 20844: 20840: 20837: 20834: 20830: 20826: 20822: 20818: 20814: 20810: 20807: 20804: 20803: 20800: 20797: 20795: 20788: 20777: 20773: 20770: 20767: 20766: 20763: 20757: 20754: 20752: 20749: 20746: 20742: 20739: 20737: 20734: 20731: 20727: 20723: 20719: 20716: 20714: 20711: 20709: 20706: 20704: 20701: 20699: 20696: 20694: 20691: 20689: 20686: 20684: 20681: 20679: 20676: 20674: 20671: 20669: 20666: 20664: 20661: 20659: 20656: 20654: 20651: 20649: 20646: 20644: 20641: 20639: 20636: 20634: 20631: 20629: 20626: 20624: 20621: 20619: 20616: 20614: 20611: 20608: 20604: 20600: 20596: 20592: 20591:bromocriptine 20588: 20584: 20581: 20579: 20576: 20574: 20571: 20568: 20564: 20560: 20556: 20552: 20548: 20544: 20540: 20536: 20532: 20531:brexpiprazole 20528: 20524: 20520: 20516: 20513: 20511: 20508: 20505: 20504: 20501: 20494: 20490: 20486: 20482: 20478: 20474: 20470: 20466: 20462: 20458: 20454: 20450: 20446: 20443: 20441: 20438: 20436: 20433: 20431: 20428: 20425: 20421: 20418: 20415: 20411: 20407: 20403: 20399: 20396: 20394: 20391: 20388: 20384: 20380: 20376: 20372: 20368: 20364: 20360: 20357: 20354: 20350: 20346: 20342: 20338: 20335: 20333: 20330: 20327: 20323: 20319: 20315: 20311: 20307: 20303: 20300: 20298: 20295: 20293: 20290: 20287: 20286: 20283: 20280: 20278: 20271: 20260: 20256: 20252: 20249: 20246: 20245: 20242: 20236: 20233: 20231: 20228: 20226: 20223: 20220: 20216: 20212: 20208: 20204: 20200: 20196: 20192: 20188: 20184: 20180: 20176: 20172: 20168: 20164: 20161: 20158: 20157:amitriptyline 20154: 20151: 20148: 20144: 20140: 20136: 20135:esmirtazapine 20132: 20128: 20124: 20121: 20119: 20116: 20114: 20111: 20109: 20106: 20104: 20101: 20098: 20094: 20093:triazoledione 20090: 20086: 20082: 20078: 20074: 20070: 20067: 20065: 20062: 20060: 20057: 20055: 20052: 20050: 20047: 20045: 20042: 20040: 20037: 20035: 20032: 20030: 20027: 20025: 20022: 20020: 20017: 20015: 20012: 20010: 20007: 20005: 20002: 20000: 19997: 19995: 19994:Naftidrofuryl 19992: 19990: 19987: 19985: 19982: 19980: 19977: 19975: 19972: 19970: 19967: 19965: 19962: 19960: 19957: 19955: 19952: 19950: 19947: 19945: 19942: 19940: 19937: 19935: 19932: 19929: 19925: 19921: 19917: 19913: 19909: 19905: 19901: 19898: 19896: 19893: 19891: 19888: 19886: 19883: 19881: 19878: 19876: 19873: 19871: 19868: 19865: 19861: 19857: 19853: 19849: 19845: 19841: 19837: 19833: 19829: 19825: 19821: 19817: 19813: 19809: 19805: 19801: 19797: 19793: 19789: 19788:brexpiprazole 19785: 19781: 19777: 19773: 19769: 19766: 19764: 19761: 19758: 19754: 19750: 19746: 19742: 19739: 19737: 19734: 19732: 19729: 19727: 19724: 19722: 19719: 19717: 19714: 19711: 19710: 19707: 19700: 19696: 19692: 19688: 19684: 19680: 19676: 19672: 19668: 19664: 19660: 19657: 19655: 19652: 19650: 19647: 19645: 19642: 19639: 19635: 19631: 19627: 19624: 19621: 19617: 19613: 19610: 19608: 19605: 19603: 19600: 19598: 19595: 19593: 19590: 19588: 19585: 19583: 19580: 19578: 19575: 19572: 19568: 19564: 19560: 19556: 19553: 19551: 19548: 19546: 19543: 19541: 19538: 19536: 19533: 19530: 19526: 19522: 19518: 19514: 19510: 19506: 19502: 19498: 19494: 19490: 19486: 19482: 19478: 19477:bromocriptine 19474: 19470: 19466: 19463: 19461: 19458: 19455: 19451: 19447: 19443: 19439: 19436: 19434: 19431: 19429: 19426: 19424: 19421: 19419: 19416: 19414: 19411: 19408: 19404: 19400: 19396: 19392: 19388: 19384: 19380: 19377: 19374: 19370: 19366: 19362: 19358: 19354: 19351: 19349: 19346: 19344: 19341: 19338: 19334: 19330: 19326: 19322: 19318: 19314: 19311: 19308: 19304: 19300: 19296: 19292: 19288: 19284: 19280: 19276: 19272: 19268: 19265: 19264: 19261: 19258: 19256: 19249: 19246: 19244: 19237: 19223: 19220: 19218: 19215: 19212: 19211: 19208: 19201: 19197: 19194: 19191: 19187: 19183: 19179: 19176: 19174: 19171: 19169: 19166: 19164: 19161: 19158: 19155: 19151: 19147: 19146:bromocriptine 19143: 19140: 19138: 19135: 19133: 19130: 19127: 19126: 19123: 19120: 19118: 19111: 19101: 19097: 19093: 19089: 19086: 19083: 19082: 19079: 19073: 19070: 19067: 19066: 19063: 19056: 19052: 19049: 19046: 19042: 19039: 19037: 19034: 19031: 19027: 19024: 19022: 19019: 19016: 19015: 19012: 19009: 19007: 19000: 18989: 18985: 18981: 18977: 18974: 18972: 18969: 18966: 18965: 18962: 18956: 18953: 18951: 18948: 18946: 18943: 18941: 18938: 18936: 18933: 18931: 18928: 18926: 18923: 18921: 18918: 18916: 18913: 18911: 18908: 18906: 18903: 18901: 18898: 18895: 18891: 18888: 18886: 18883: 18881: 18878: 18876: 18873: 18870: 18869: 18866: 18859: 18855: 18851: 18847: 18843: 18839: 18835: 18832: 18829: 18825: 18821: 18817: 18813: 18809: 18805: 18801: 18797: 18793: 18790: 18788: 18785: 18783: 18780: 18778: 18775: 18773: 18770: 18768: 18765: 18763: 18760: 18758: 18755: 18753: 18750: 18747: 18743: 18739: 18735: 18731: 18727: 18726:bromocriptine 18723: 18720: 18718: 18715: 18713: 18710: 18708: 18705: 18702: 18701: 18698: 18695: 18693: 18686: 18675: 18671: 18667: 18663: 18660: 18657: 18656: 18653: 18647: 18644: 18642: 18639: 18637: 18634: 18632: 18629: 18627: 18624: 18622: 18619: 18617: 18614: 18612: 18609: 18606: 18602: 18599: 18597: 18594: 18591: 18587: 18583: 18579: 18575: 18571: 18567: 18563: 18562:Beta blockers 18560: 18558: 18555: 18552: 18551: 18548: 18542: 18539: 18536: 18532: 18528: 18524: 18520: 18517: 18515: 18512: 18509: 18505: 18501: 18497: 18493: 18489: 18486: 18484: 18481: 18479: 18476: 18474: 18471: 18468: 18464: 18460: 18456: 18452: 18448: 18447:bromocriptine 18444: 18441: 18439: 18436: 18434: 18431: 18429: 18426: 18424: 18421: 18419: 18416: 18414: 18411: 18409: 18406: 18403: 18402: 18399: 18396: 18394: 18387: 18376: 18372: 18369: 18367: 18364: 18362: 18359: 18356: 18355: 18352: 18346: 18343: 18341: 18338: 18336: 18333: 18331: 18328: 18326: 18323: 18321: 18318: 18316: 18313: 18311: 18308: 18306: 18303: 18301: 18298: 18296: 18293: 18291: 18288: 18286: 18283: 18281: 18278: 18276: 18273: 18271: 18268: 18266: 18263: 18261: 18258: 18256: 18253: 18251: 18248: 18246: 18243: 18240: 18236: 18233: 18231: 18228: 18226: 18223: 18221: 18218: 18215: 18211: 18207: 18203: 18199: 18195: 18191: 18187: 18183: 18182:cyanopindolol 18179: 18175: 18171: 18170:Beta blockers 18168: 18166: 18163: 18160: 18156: 18152: 18148: 18145: 18142: 18141: 18138: 18132: 18129: 18127: 18124: 18122: 18119: 18117: 18114: 18112: 18109: 18107: 18104: 18101: 18097: 18093: 18089: 18085: 18081: 18077: 18073: 18069: 18065: 18062: 18060: 18057: 18055: 18052: 18050: 18047: 18045: 18042: 18040: 18037: 18035: 18032: 18030: 18027: 18025: 18022: 18020: 18017: 18015: 18012: 18010: 18007: 18005: 18002: 18000: 17997: 17995: 17992: 17990: 17987: 17985: 17982: 17980: 17977: 17975: 17972: 17970: 17967: 17965: 17962: 17960: 17957: 17955: 17952: 17950: 17947: 17945: 17942: 17940: 17937: 17935: 17932: 17930: 17927: 17925: 17922: 17920: 17917: 17915: 17912: 17910: 17907: 17905: 17902: 17899: 17895: 17891: 17887: 17883: 17879: 17875: 17871: 17867: 17866:bromocriptine 17863: 17860: 17858: 17855: 17853: 17850: 17848: 17845: 17843: 17840: 17838: 17835: 17833: 17830: 17828: 17825: 17823: 17820: 17818: 17815: 17812: 17808: 17804: 17800: 17796: 17792: 17789: 17786: 17782: 17778: 17774: 17770: 17766: 17765:brexpiprazole 17762: 17758: 17754: 17751: 17748: 17744: 17740: 17739:triazoledione 17736: 17732: 17728: 17724: 17720: 17717: 17715: 17712: 17710: 17707: 17705: 17702: 17699: 17698: 17695: 17692: 17690: 17683: 17680: 17678: 17671: 17667: 17664: 17657: 17652: 17650: 17645: 17643: 17638: 17637: 17634: 17622: 17619: 17617: 17614: 17612: 17609: 17606: 17605: 17602: 17596: 17593: 17591: 17588: 17586: 17583: 17581: 17578: 17576: 17573: 17571: 17568: 17566: 17563: 17561: 17558: 17556: 17553: 17550: 17546: 17543: 17541: 17538: 17536: 17533: 17532: 17530: 17526: 17520: 17516: 17506: 17503: 17501: 17498: 17496: 17493: 17491: 17488: 17486: 17483: 17481: 17478: 17476: 17473: 17471: 17468: 17466: 17463: 17461: 17458: 17456: 17453: 17451: 17448: 17446: 17443: 17441: 17438: 17436: 17433: 17431: 17428: 17426: 17423: 17421: 17418: 17416: 17413: 17411: 17408: 17406: 17405:Phencyclidine 17403: 17401: 17398: 17396: 17393: 17391: 17388: 17386: 17383: 17381: 17378: 17376: 17375:Nitrous oxide 17373: 17371: 17368: 17366: 17363: 17361: 17358: 17356: 17353: 17351: 17348: 17346: 17343: 17341: 17338: 17336: 17333: 17331: 17328: 17326: 17323: 17321: 17318: 17316: 17315:Levomethadone 17313: 17311: 17308: 17306: 17303: 17301: 17298: 17296: 17293: 17291: 17288: 17286: 17283: 17281: 17278: 17276: 17273: 17271: 17268: 17266: 17263: 17261: 17260:Hexafluronium 17258: 17256: 17253: 17251: 17248: 17246: 17243: 17241: 17238: 17236: 17233: 17231: 17228: 17226: 17223: 17221: 17218: 17216: 17213: 17211: 17208: 17206: 17203: 17201: 17198: 17196: 17193: 17191: 17188: 17186: 17183: 17181: 17178: 17176: 17173: 17171: 17168: 17166: 17163: 17161: 17158: 17156: 17153: 17151: 17150:Decamethonium 17148: 17146: 17143: 17141: 17138: 17136: 17133: 17131: 17128: 17126: 17123: 17121: 17120:Cisatracurium 17118: 17116: 17113: 17111: 17108: 17106: 17103: 17101: 17098: 17096: 17093: 17090: 17086: 17082: 17081:Bungarotoxins 17079: 17077: 17074: 17071: 17067: 17066:pentobarbital 17063: 17060: 17058: 17055: 17053: 17050: 17048: 17045: 17043: 17040: 17038: 17035: 17033: 17030: 17028: 17025: 17022: 17018: 17014: 17010: 17009:α-Neurotoxins 17007: 17005: 17002: 17000: 16997: 16996: 16994: 16988: 16981: 16977: 16971: 16968: 16966: 16963: 16961: 16958: 16956: 16953: 16951: 16948: 16946: 16943: 16941: 16938: 16936: 16933: 16931: 16928: 16926: 16923: 16921: 16918: 16916: 16913: 16911: 16908: 16906: 16903: 16901: 16898: 16896: 16893: 16891: 16888: 16886: 16883: 16881: 16878: 16876: 16873: 16871: 16868: 16866: 16863: 16861: 16858: 16856: 16853: 16851: 16848: 16846: 16843: 16841: 16838: 16836: 16833: 16831: 16828: 16826: 16823: 16821: 16818: 16816: 16813: 16810: 16806: 16803: 16801: 16798: 16796: 16793: 16791: 16788: 16786: 16783: 16781: 16778: 16776: 16773: 16771: 16768: 16766: 16763: 16761: 16758: 16756: 16753: 16751: 16748: 16746: 16743: 16741: 16738: 16736: 16733: 16731: 16728: 16726: 16723: 16721: 16718: 16716: 16713: 16711: 16710:Decamethonium 16708: 16706: 16703: 16701: 16698: 16696: 16693: 16691: 16688: 16686: 16683: 16681: 16678: 16676: 16673: 16671: 16668: 16666: 16663: 16661: 16658: 16656: 16653: 16651: 16648: 16646: 16645:Acetylcholine 16643: 16641: 16638: 16636: 16633: 16631: 16628: 16626: 16623: 16621: 16618: 16616: 16613: 16611: 16608: 16606: 16603: 16601: 16598: 16596: 16593: 16592: 16590: 16584: 16577: 16573: 16570: 16565: 16559: 16555: 16552: 16545: 16540: 16538: 16533: 16531: 16526: 16525: 16522: 16511: 16510: 16506: 16502: 16501:Serotonergics 16498: 16497:Dopaminergics 16494: 16490: 16486: 16483: 16476: 16470: 16467: 16463: 16460: 16458: 16455: 16454:Agonist-like: 16452: 16449: 16448: 16445: 16442: 16439: 16438: 16436: 16432: 16426: 16423: 16421: 16418: 16416: 16415:Tetrabenazine 16413: 16411: 16408: 16406: 16403: 16401: 16398: 16396: 16393: 16391: 16388: 16386: 16383: 16381: 16378: 16376: 16373: 16371: 16368: 16366: 16363: 16361: 16358: 16356: 16353: 16351: 16348: 16346: 16343: 16341: 16338: 16335: 16331: 16327: 16323: 16320: 16318: 16315: 16314: 16312: 16307: 16301: 16291: 16288: 16285: 16281: 16277: 16273: 16269: 16265: 16261: 16258: 16256: 16253: 16251: 16248: 16246: 16243: 16241: 16238: 16236: 16233: 16231: 16228: 16226: 16223: 16221: 16218: 16216: 16213: 16211: 16208: 16206: 16203: 16200: 16199:phencyclidine 16196: 16195:methoxetamine 16192: 16188: 16184: 16180: 16177: 16174: 16170: 16166: 16163: 16160: 16156: 16152: 16148: 16144: 16140: 16136: 16132: 16129: 16127: 16124: 16122: 16119: 16116: 16115: 16112: 16106: 16105:Protriptyline 16103: 16101: 16098: 16096: 16095:Nortriptyline 16093: 16091: 16088: 16086: 16083: 16081: 16078: 16076: 16073: 16071: 16068: 16066: 16063: 16061: 16058: 16056: 16053: 16051: 16050:Amitriptyline 16048: 16045: 16044: 16041: 16034: 16030: 16027: 16025: 16022: 16020: 16017: 16015: 16014:Tedatioxetine 16012: 16010: 16007: 16005: 16002: 16000: 15997: 15995: 15992: 15990: 15987: 15985: 15982: 15980: 15977: 15975: 15972: 15970: 15967: 15965: 15962: 15960: 15957: 15955: 15952: 15950: 15947: 15945: 15942: 15940: 15937: 15935: 15932: 15930: 15927: 15925: 15922: 15920: 15917: 15915: 15912: 15910: 15907: 15905: 15902: 15900: 15897: 15895: 15892: 15890: 15887: 15885: 15882: 15880: 15877: 15875: 15874:Centanafadine 15872: 15870: 15867: 15865: 15862: 15860: 15857: 15855: 15852: 15850: 15847: 15844: 15843: 15840: 15834: 15831: 15829: 15826: 15824: 15821: 15819: 15818:N-Methyl-PPPA 15816: 15814: 15811: 15809: 15806: 15804: 15801: 15799: 15796: 15794: 15791: 15789: 15786: 15784: 15781: 15779: 15776: 15774: 15771: 15768: 15767: 15764: 15758: 15755: 15753: 15750: 15748: 15745: 15743: 15740: 15738: 15735: 15733: 15730: 15728: 15725: 15723: 15720: 15718: 15715: 15713: 15710: 15707: 15706: 15703: 15700: 15698: 15695: 15693: 15690: 15688: 15685: 15683: 15680: 15678: 15675: 15673: 15670: 15668: 15665: 15663: 15660: 15658: 15657:Norfluoxetine 15655: 15653: 15650: 15648: 15645: 15643: 15640: 15638: 15635: 15633: 15630: 15628: 15625: 15623: 15620: 15618: 15615: 15613: 15610: 15608: 15605: 15603: 15600: 15598: 15597:Centpropazine 15595: 15593: 15590: 15588: 15585: 15582: 15581: 15578: 15575: 15568: 15557: 15551: 15540: 15536: 15532: 15528: 15524: 15520: 15519:desmetramadol 15516: 15513: 15511: 15508: 15506: 15503: 15501: 15500: 15499:Ginkgo biloba 15496: 15494: 15491: 15489: 15486: 15483: 15482:phencyclidine 15479: 15475: 15472: 15469: 15465: 15461: 15458: 15455: 15451: 15447: 15443: 15439: 15436: 15433: 15432: 15429: 15423: 15420: 15418: 15415: 15413: 15410: 15408: 15405: 15403: 15400: 15397: 15396: 15393: 15387: 15384: 15382: 15381:Protriptyline 15379: 15377: 15376:Nortriptyline 15374: 15372: 15369: 15367: 15364: 15362: 15359: 15357: 15354: 15352: 15349: 15347: 15344: 15342: 15339: 15337: 15334: 15332: 15329: 15327: 15326:Amitriptyline 15324: 15321: 15320: 15317: 15310: 15306: 15303: 15301: 15298: 15296: 15293: 15291: 15290:Tedatioxetine 15288: 15286: 15283: 15281: 15278: 15276: 15273: 15271: 15268: 15266: 15263: 15261: 15258: 15256: 15253: 15251: 15248: 15246: 15243: 15241: 15238: 15236: 15233: 15231: 15228: 15226: 15223: 15221: 15218: 15216: 15213: 15211: 15208: 15206: 15203: 15201: 15198: 15196: 15193: 15191: 15188: 15186: 15183: 15181: 15178: 15176: 15173: 15171: 15168: 15166: 15163: 15161: 15158: 15156: 15153: 15151: 15150:Centanafadine 15148: 15146: 15143: 15141: 15138: 15136: 15133: 15131: 15128: 15126: 15123: 15120: 15119: 15116: 15110: 15107: 15105: 15102: 15100: 15097: 15095: 15092: 15090: 15089:N-Methyl-PPPA 15087: 15085: 15082: 15080: 15077: 15075: 15072: 15070: 15067: 15065: 15062: 15060: 15057: 15055: 15052: 15050: 15047: 15044: 15043: 15040: 15034: 15031: 15029: 15026: 15024: 15021: 15019: 15016: 15014: 15011: 15009: 15006: 15004: 15001: 14999: 14996: 14994: 14991: 14989: 14986: 14984: 14981: 14979: 14976: 14974: 14971: 14969: 14966: 14964: 14961: 14958: 14957: 14954: 14948: 14945: 14943: 14940: 14938: 14935: 14933: 14930: 14928: 14925: 14923: 14920: 14918: 14915: 14913: 14910: 14908: 14905: 14903: 14900: 14898: 14895: 14893: 14890: 14888: 14885: 14883: 14880: 14878: 14875: 14872: 14871: 14868: 14865: 14858: 14847: 14841: 14831: 14828: 14826: 14823: 14821: 14818: 14816: 14815:Tedatioxetine 14813: 14811: 14808: 14806: 14803: 14801: 14798: 14796: 14793: 14791: 14788: 14786: 14783: 14781: 14778: 14776: 14773: 14771: 14768: 14766: 14763: 14761: 14758: 14756: 14753: 14751: 14748: 14746: 14743: 14741: 14738: 14736: 14733: 14731: 14728: 14726: 14723: 14721: 14718: 14716: 14713: 14711: 14708: 14706: 14703: 14701: 14698: 14696: 14693: 14691: 14688: 14686: 14683: 14681: 14678: 14676: 14673: 14671: 14668: 14666: 14663: 14661: 14658: 14656: 14653: 14651: 14648: 14646: 14643: 14641: 14638: 14636: 14633: 14631: 14628: 14626: 14623: 14621: 14618: 14616: 14613: 14611: 14608: 14606: 14603: 14601: 14598: 14596: 14593: 14591: 14588: 14586: 14583: 14581: 14580: 14576: 14574: 14571: 14569: 14566: 14564: 14561: 14559: 14556: 14554: 14551: 14549: 14546: 14544: 14541: 14539: 14536: 14534: 14531: 14528: 14527: 14524: 14518: 14515: 14513: 14510: 14508: 14505: 14503: 14500: 14498: 14495: 14493: 14490: 14488: 14485: 14483: 14480: 14478: 14475: 14473: 14470: 14468: 14465: 14463: 14460: 14458: 14455: 14453: 14450: 14448: 14445: 14443: 14440: 14438: 14437:Ioflupane (I) 14435: 14433: 14430: 14428: 14425: 14423: 14420: 14418: 14415: 14413: 14410: 14408: 14405: 14403: 14400: 14398: 14395: 14393: 14390: 14388: 14385: 14382: 14381: 14378: 14372: 14369: 14367: 14364: 14362: 14359: 14357: 14354: 14352: 14349: 14348:Pyrrolidines: 14346: 14345: 14342: 14336: 14335:Tenocyclidine 14333: 14331: 14328: 14326: 14323: 14321: 14320:Phencyclidine 14318: 14316: 14313: 14311: 14308: 14306: 14303: 14301: 14298: 14296: 14293: 14291: 14288: 14286: 14283: 14281: 14278: 14276: 14273: 14270: 14269: 14266: 14260: 14257: 14255: 14252: 14250: 14247: 14245: 14242: 14240: 14237: 14235: 14232: 14230: 14227: 14225: 14222: 14219: 14218: 14215: 14212: 14205: 14194: 14188: 14184: 14177: 14172: 14170: 14165: 14163: 14158: 14157: 14154: 14142: 14141: 14138: 14134: 14133: 14130: 14123: 14122: 14117: 14114: 14112: 14109: 14106: 14105: 14100: 14097: 14094: 14090: 14086: 14082: 14079: 14077: 14074: 14072: 14069: 14067: 14064: 14062: 14059: 14057: 14054: 14052: 14049: 14047: 14044: 14042: 14039: 14037: 14034: 14032: 14029: 14027: 14024: 14022: 14019: 14017: 14014: 14011: 14007: 14003: 13999: 13996: 13995: 13993: 13989: 13982: 13979:Mixed (e.g., 13978: 13975: 13971: 13967: 13964: 13961: 13957: 13953: 13949: 13945: 13942: 13939: 13935: 13931: 13927: 13924: 13923: 13921: 13919: 13915: 13909: 13906: 13904: 13901: 13899: 13896: 13894: 13891: 13889: 13886: 13884: 13881: 13879: 13876: 13874: 13871: 13869: 13866: 13864: 13861: 13859: 13856: 13854: 13853:Acetildenafil 13851: 13850: 13848: 13846: 13842: 13836: 13833: 13831: 13828: 13826: 13825:Bremelanotide 13823: 13822: 13820: 13818: 13814: 13808: 13805: 13803: 13800: 13798: 13795: 13793: 13790: 13788: 13785: 13783: 13780: 13778: 13775: 13773: 13770: 13768: 13765: 13763: 13760: 13759: 13757: 13755: 13751: 13747: 13744: 13737: 13732: 13730: 13725: 13723: 13718: 13717: 13714: 13698: 13696: 13693: 13692: 13690: 13687: 13684: 13681: 13679: 13676: 13675: 13671: 13665: 13662: 13660: 13657: 13655: 13652: 13650: 13647: 13645: 13644:Setmelanotide 13642: 13640: 13637: 13635: 13632: 13630: 13627: 13625: 13622: 13620: 13617: 13615: 13612: 13611: 13609: 13605: 13599: 13596: 13595: 13593: 13591: 13587: 13581: 13578: 13576: 13573: 13571: 13568: 13566: 13563: 13561: 13558: 13557: 13555: 13551: 13545: 13542: 13540: 13537: 13536: 13534: 13532: 13526: 13519: 13515: 13512: 13511: 13509: 13507: 13503: 13496: 13493: 13490: 13489:+cagrilintide 13486: 13483: 13481: 13478: 13476: 13475:Oxyntomodulin 13473: 13471: 13468: 13466: 13463: 13460: 13457: 13455: 13452: 13450: 13447: 13445: 13442: 13440: 13437: 13435: 13432: 13431: 13429: 13427: 13423: 13419: 13415: 13411: 13405: 13402: 13400: 13397: 13395: 13392: 13390: 13387: 13385: 13382: 13380: 13377: 13375: 13372: 13371: 13369: 13367: 13361: 13351: 13348: 13346: 13343: 13341: 13338: 13336: 13333: 13331: 13328: 13326: 13323: 13321: 13320:Phenmetrazine 13318: 13316: 13313: 13311: 13308: 13306: 13303: 13301: 13298: 13296: 13293: 13290: 13286: 13283: 13281: 13278: 13276: 13273: 13271: 13268: 13266: 13263: 13260: 13256: 13253: 13251: 13248: 13246: 13243: 13241: 13238: 13237: 13235: 13231: 13224: 13220: 13217: 13215: 13212: 13210: 13207: 13205: 13202: 13200: 13197: 13195: 13192: 13190: 13187: 13185: 13182: 13181: 13179: 13177: 13173: 13167: 13164: 13162: 13161:Xylopropamine 13159: 13156: 13152: 13149: 13147: 13144: 13142: 13139: 13137: 13134: 13132: 13129: 13127: 13124: 13122: 13119: 13117: 13114: 13112: 13109: 13107: 13104: 13102: 13099: 13097: 13094: 13092: 13089: 13087: 13084: 13082: 13079: 13077: 13074: 13072: 13069: 13067: 13064: 13062: 13059: 13057: 13054: 13052: 13049: 13047: 13044: 13042: 13039: 13037: 13036:Benzphetamine 13034: 13032: 13029: 13027: 13024: 13022: 13019: 13017: 13014: 13012: 13009: 13007: 13004: 13003: 13001: 12999: 12994: 12990: 12987: 12985: 12981: 12976: 12972: 12968: 12961: 12956: 12954: 12949: 12947: 12942: 12941: 12938: 12925: 12924:Phenobarbital 12921: 12920: 12916: 12913: 12910: 12908: 12905: 12903: 12900: 12898: 12894: 12893: 12889: 12886: 12882: 12878: 12872: 12871: 12869: 12867: 12863: 12856: 12853: 12851: 12847: 12846: 12842: 12838: 12835: 12833: 12830: 12828: 12825: 12823: 12820: 12818: 12815: 12813: 12810: 12807: 12803: 12802:Buprenorphine 12800: 12799: 12798: 12797: 12793: 12791: 12788: 12785: 12782: 12780: 12776: 12772: 12766: 12765: 12763: 12761: 12757: 12751: 12748: 12746: 12743: 12740: 12736: 12732: 12726: 12724: 12721: 12717: 12714: 12712: 12709: 12708: 12707: 12706: 12702: 12698: 12697:Nitrous oxide 12695: 12694: 12693: 12692: 12688: 12684: 12681: 12679: 12676: 12674: 12671: 12669: 12666: 12665: 12664: 12663: 12656: 12655: 12653: 12651: 12647: 12640: 12636: 12632: 12626: 12624: 12621: 12619: 12616: 12614: 12611: 12609: 12606: 12604: 12601: 12600: 12598: 12596: 12592: 12587: 12583: 12580:Treatment of 12575: 12570: 12568: 12563: 12561: 12556: 12555: 12552: 12536: 12534: 12531: 12530: 12528: 12525: 12522: 12519: 12517: 12514: 12513: 12509: 12499: 12496: 12494: 12491: 12489: 12482: 12480: 12478: 12474: 12471: 12467: 12463: 12462:neurosteroids 12460: 12457: 12455: 12448: 12447: 12444: 12440:Miscellaneous 12437: 12433: 12418: 12417:levothyroxine 12410: 12406: 12403: 12400: 12396: 12392: 12389: 12387: 12384: 12381: 12377: 12373: 12369: 12365: 12364:brexpiprazole 12361: 12357: 12354: 12353: 12350: 12346: 12341: 12337: 12323: 12320: 12319:Irreversible: 12317: 12316: 12314: 12308: 12299: 12293: 12290: 12288: 12285: 12283: 12280: 12278: 12275: 12273: 12270: 12268: 12265: 12263: 12260: 12257: 12256: 12254: 12248: 12239: 12233: 12230: 12227: 12226: 12223: 12220: 12217: 12216: 12213: 12210: 12208: 12205: 12203: 12200: 12198: 12195: 12193: 12190: 12188: 12185: 12183: 12180: 12178: 12175: 12173: 12170: 12168: 12165: 12163: 12160: 12158: 12155: 12153: 12152:Isocarboxazid 12150: 12148: 12145: 12143: 12140: 12138: 12135: 12134:Irreversible: 12132: 12131: 12129: 12127:Non-selective 12125: 12121: 12117: 12112: 12108: 12094: 12091: 12090: 12088: 12084: 12078: 12075: 12073: 12070: 12068: 12065: 12063: 12060: 12059: 12057: 12052: 12046: 12040: 12037: 12035: 12032: 12030: 12027: 12025: 12024:Protriptyline 12022: 12020: 12017: 12015: 12012: 12010: 12007: 12005: 12002: 12000: 11999:Nortriptyline 11997: 11995: 11994:Nitroxazepine 11992: 11990: 11987: 11985: 11982: 11980: 11977: 11975: 11972: 11970: 11967: 11965: 11962: 11960: 11957: 11955: 11952: 11950: 11947: 11945: 11942: 11940: 11937: 11935: 11934:Demexiptiline 11932: 11930: 11927: 11925: 11922: 11920: 11917: 11915: 11912: 11910: 11909:Amitriptyline 11907: 11905: 11902: 11901: 11899: 11894: 11888: 11884: 11880: 11876: 11871: 11867: 11853: 11850: 11848: 11845: 11843: 11840: 11838: 11835: 11833: 11830: 11828: 11825: 11823: 11820: 11818: 11815: 11813: 11810: 11808: 11805: 11803: 11800: 11798: 11795: 11793: 11790: 11788: 11785: 11783: 11780: 11778: 11775: 11774: 11772: 11768: 11762: 11759: 11757: 11754: 11753: 11751: 11746: 11740: 11734: 11731: 11729: 11726: 11724: 11721: 11720: 11718: 11713: 11707: 11701: 11698: 11696: 11693: 11691: 11688: 11687: 11685: 11680: 11674: 11668: 11665: 11663: 11660: 11658: 11655: 11654: 11652: 11647: 11641: 11635: 11632: 11630: 11627: 11625: 11622: 11621: 11619: 11614: 11608: 11602: 11599: 11597: 11594: 11592: 11589: 11587: 11584: 11582: 11579: 11577: 11574: 11573: 11571: 11566: 11560: 11554: 11551: 11549: 11546: 11544: 11541: 11539: 11536: 11534: 11531: 11529: 11526: 11524: 11521: 11519: 11516: 11515: 11513: 11508: 11502: 11498: 11494: 11490: 11484: 11480: 11475: 11471: 11464: 11459: 11457: 11452: 11450: 11445: 11444: 11441: 11430: 11426: 11421: 11416: 11412: 11408: 11404: 11397: 11389: 11385: 11381: 11377: 11373: 11369: 11362: 11354: 11350: 11346: 11342: 11338: 11334: 11327: 11319: 11313: 11309: 11302: 11286: 11282: 11278: 11272: 11264: 11258: 11254: 11247: 11240: 11228: 11224: 11220: 11214: 11206: 11202: 11198: 11194: 11190: 11186: 11182: 11178: 11171: 11163: 11159: 11155: 11151: 11147: 11143: 11136: 11128: 11124: 11120: 11116: 11112: 11108: 11104: 11100: 11093: 11086: 11082: 11079: 11074: 11066: 11062: 11057: 11052: 11048: 11044: 11037: 11029: 11025: 11021: 11017: 11013: 11009: 11005: 11001: 10994: 10992: 10975: 10971: 10967: 10960: 10944: 10940: 10936: 10930: 10911: 10907: 10900: 10893: 10877: 10873: 10869: 10862: 10846: 10842: 10838: 10831: 10815: 10811: 10807: 10803: 10797: 10778: 10774: 10770: 10763: 10757: 10741: 10737: 10733: 10727: 10711: 10707: 10705: 10699: 10693: 10677: 10673: 10669: 10662: 10655: 10654:public domain 10636: 10632: 10628: 10622: 10620: 10618: 10601: 10597: 10596: 10591: 10585: 10569: 10565: 10564: 10559: 10552: 10536: 10532: 10526: 10510: 10506: 10500: 10481: 10477: 10475: 10466: 10460: 10444: 10440: 10438: 10432: 10426: 10410: 10406: 10404: 10398: 10392: 10376: 10372: 10368: 10364: 10357: 10355: 10338: 10334: 10328: 10312: 10308: 10302: 10294: 10290: 10286: 10282: 10278: 10274: 10267: 10259: 10255: 10250: 10245: 10241: 10237: 10233: 10229: 10225: 10218: 10210: 10206: 10201: 10196: 10192: 10188: 10184: 10177: 10169: 10165: 10161: 10157: 10152: 10147: 10143: 10139: 10135: 10128: 10113: 10107: 10103: 10102: 10094: 10078: 10074: 10068: 10066: 10050: 10046: 10040: 10038: 10029: 10025: 10021: 10017: 10013: 10009: 10002: 9994: 9990: 9986: 9982: 9978: 9974: 9967: 9959: 9955: 9951: 9947: 9943: 9939: 9932: 9930: 9921: 9917: 9913: 9909: 9905: 9901: 9894: 9892: 9883: 9879: 9875: 9869: 9865: 9861: 9857: 9850: 9848: 9846: 9844: 9834: 9826: 9822: 9818: 9814: 9807: 9799: 9795: 9791: 9787: 9783: 9779: 9771: 9763: 9757: 9753: 9752: 9744: 9728: 9724: 9720: 9716: 9712: 9708: 9704: 9700: 9693: 9691: 9682: 9678: 9674: 9670: 9666: 9662: 9658: 9654: 9647: 9645: 9636: 9632: 9628: 9624: 9621:(6): 2502–5. 9620: 9616: 9608: 9600: 9596: 9591: 9586: 9582: 9578: 9574: 9570: 9566: 9559: 9551: 9547: 9543: 9539: 9535: 9531: 9527: 9523: 9516: 9508: 9504: 9500: 9496: 9492: 9488: 9484: 9480: 9473: 9465: 9461: 9456: 9451: 9447: 9443: 9442:Res Pharm Sci 9439: 9432: 9424: 9420: 9416: 9412: 9407: 9402: 9398: 9394: 9390: 9383: 9381: 9373: 9368: 9364: 9360: 9356: 9352: 9348: 9347:CNS Spectrums 9341: 9333: 9329: 9325: 9321: 9317: 9313: 9306: 9298: 9294: 9289: 9284: 9279: 9274: 9270: 9266: 9262: 9255: 9247: 9243: 9239: 9235: 9231: 9227: 9219: 9212: 9207: 9203: 9199: 9195: 9191: 9187: 9180: 9178: 9169: 9165: 9161: 9157: 9153: 9149: 9142: 9140: 9138: 9129: 9125: 9120: 9115: 9111: 9107: 9104:: 1114–1136. 9103: 9099: 9095: 9088: 9086: 9084: 9075: 9071: 9067: 9063: 9059: 9055: 9051: 9047: 9040: 9032: 9028: 9023: 9018: 9014: 9010: 9006: 9002: 8998: 8991: 8983: 8979: 8975: 8971: 8967: 8963: 8956: 8954: 8952: 8950: 8940: 8932: 8928: 8924: 8920: 8916: 8912: 8911:Mol Pharmacol 8904: 8896: 8892: 8888: 8884: 8880: 8876: 8869: 8861: 8857: 8853: 8849: 8845: 8841: 8834: 8826: 8822: 8818: 8814: 8810: 8806: 8799: 8791: 8787: 8783: 8779: 8775: 8771: 8764: 8756: 8752: 8749:(1): 94–102. 8748: 8744: 8737: 8722: 8718: 8712: 8710: 8694: 8690: 8683: 8681: 8664: 8660: 8653:, Driscol J. 8652: 8646: 8644: 8635: 8631: 8626: 8621: 8617: 8613: 8609: 8605: 8601: 8594: 8586: 8582: 8577: 8572: 8568: 8564: 8560: 8556: 8552: 8545: 8537: 8533: 8529: 8525: 8521: 8517: 8513: 8509: 8501: 8499: 8490: 8486: 8482: 8478: 8474: 8470: 8463: 8455: 8451: 8447: 8443: 8439: 8435: 8431: 8427: 8420: 8418: 8416: 8407: 8403: 8398: 8393: 8389: 8385: 8381: 8377: 8373: 8366: 8364: 8362: 8360: 8358: 8349: 8345: 8341: 8337: 8333: 8329: 8325: 8321: 8314: 8306: 8302: 8297: 8292: 8288: 8284: 8280: 8276: 8272: 8265: 8257: 8253: 8249: 8245: 8241: 8237: 8230: 8222: 8218: 8214: 8210: 8206: 8202: 8195: 8187: 8183: 8179: 8175: 8170: 8165: 8161: 8157: 8153: 8149: 8141: 8139: 8130: 8126: 8122: 8118: 8113: 8108: 8104: 8100: 8096: 8089: 8081: 8077: 8072: 8067: 8063: 8059: 8055: 8048: 8029: 8025: 8018: 8012: 8010: 8008: 7999: 7995: 7991: 7987: 7983: 7979: 7972: 7964: 7960: 7956: 7952: 7948: 7944: 7937: 7935: 7933: 7931: 7929: 7927: 7918: 7914: 7909: 7904: 7900: 7896: 7892: 7888: 7884: 7877: 7869: 7863: 7859: 7852: 7844: 7840: 7835: 7830: 7826: 7822: 7818: 7814: 7810: 7803: 7787: 7783: 7779: 7772: 7770: 7761: 7757: 7752: 7747: 7743: 7739: 7735: 7731: 7727: 7720: 7712: 7708: 7704: 7700: 7693: 7685: 7681: 7676: 7671: 7667: 7663: 7659: 7655: 7651: 7644: 7636: 7632: 7628: 7624: 7620: 7616: 7613:(2): 91–110. 7612: 7608: 7601: 7593: 7589: 7585: 7581: 7577: 7573: 7565: 7557: 7553: 7548: 7543: 7539: 7535: 7531: 7527: 7523: 7516: 7508: 7504: 7500: 7496: 7492: 7488: 7484: 7480: 7473: 7457: 7453: 7449: 7445: 7441: 7437: 7433: 7429: 7425: 7421: 7414: 7406: 7402: 7398: 7394: 7390: 7386: 7382: 7378: 7370: 7354: 7350: 7346: 7340: 7324: 7320: 7314: 7312: 7310: 7308: 7306: 7304: 7295: 7291: 7287: 7283: 7279: 7275: 7268: 7260: 7256: 7252: 7248: 7244: 7240: 7233: 7225: 7221: 7217: 7213: 7210:(4): 377–88. 7209: 7205: 7198: 7191: 7186: 7182: 7178: 7177: 7169: 7167: 7165: 7156: 7152: 7147: 7142: 7138: 7134: 7130: 7126: 7122: 7115: 7107: 7103: 7098: 7093: 7088: 7083: 7079: 7075: 7071: 7064: 7056: 7052: 7047: 7042: 7038: 7034: 7030: 7023: 7015: 7011: 7006: 7001: 6996: 6991: 6987: 6983: 6979: 6972: 6964: 6960: 6956: 6952: 6948: 6944: 6936: 6928: 6924: 6920: 6916: 6912: 6908: 6901: 6893: 6889: 6884: 6879: 6875: 6871: 6867: 6863: 6859: 6852: 6836: 6832: 6828: 6822: 6806: 6802: 6800: 6794: 6788: 6780: 6776: 6771: 6766: 6762: 6758: 6754: 6747: 6745: 6736: 6732: 6728: 6724: 6719: 6714: 6710: 6706: 6702: 6698: 6694: 6687: 6679: 6675: 6670: 6665: 6661: 6657: 6653: 6646: 6638: 6634: 6629: 6624: 6620: 6616: 6612: 6608: 6604: 6597: 6589: 6585: 6580: 6575: 6571: 6567: 6563: 6559: 6555: 6548: 6540: 6536: 6531: 6526: 6522: 6518: 6514: 6510: 6506: 6499: 6491: 6487: 6483: 6479: 6475: 6471: 6467: 6463: 6456: 6448: 6444: 6439: 6434: 6430: 6426: 6422: 6418: 6414: 6407: 6405: 6396: 6392: 6388: 6384: 6380: 6376: 6369: 6361: 6357: 6352: 6347: 6343: 6339: 6335: 6331: 6327: 6320: 6312: 6308: 6303: 6298: 6293: 6288: 6284: 6280: 6276: 6272: 6268: 6261: 6253: 6249: 6244: 6239: 6235: 6231: 6227: 6223: 6219: 6212: 6204: 6200: 6195: 6190: 6186: 6182: 6178: 6174: 6170: 6163: 6155: 6151: 6146: 6141: 6137: 6133: 6129: 6122: 6114: 6110: 6105: 6100: 6096: 6092: 6088: 6081: 6073: 6069: 6064: 6059: 6055: 6051: 6047: 6043: 6039: 6032: 6024: 6020: 6015: 6010: 6006: 6002: 5998: 5994: 5990: 5983: 5975: 5971: 5967: 5963: 5959: 5955: 5951: 5947: 5940: 5938: 5936: 5927: 5923: 5918: 5913: 5908: 5903: 5899: 5895: 5891: 5884: 5876: 5872: 5867: 5862: 5858: 5854: 5850: 5846: 5842: 5835: 5833: 5824: 5820: 5815: 5810: 5805: 5800: 5796: 5792: 5788: 5781: 5773: 5769: 5764: 5759: 5754: 5749: 5745: 5741: 5737: 5730: 5722: 5718: 5714: 5710: 5705: 5700: 5696: 5692: 5688: 5681: 5673: 5669: 5665: 5661: 5657: 5653: 5649: 5645: 5637: 5635: 5618: 5614: 5610: 5606: 5599: 5591: 5587: 5582: 5577: 5573: 5569: 5566:(13): e3165. 5565: 5561: 5557: 5550: 5542: 5538: 5533: 5528: 5524: 5520: 5516: 5512: 5508: 5501: 5493: 5489: 5484: 5479: 5476:(3): 252–60. 5475: 5471: 5467: 5460: 5452: 5448: 5443: 5438: 5433: 5428: 5424: 5420: 5416: 5409: 5401: 5397: 5392: 5387: 5383: 5379: 5375: 5371: 5367: 5360: 5358: 5349: 5345: 5340: 5335: 5330: 5325: 5321: 5317: 5313: 5309: 5305: 5298: 5296: 5294: 5285: 5281: 5276: 5271: 5267: 5263: 5259: 5255: 5251: 5244: 5242: 5240: 5220: 5216: 5212: 5208: 5204: 5199: 5194: 5190: 5186: 5182: 5178: 5171: 5164: 5162: 5160: 5158: 5149: 5145: 5141: 5137: 5133: 5129: 5125: 5121: 5113: 5104: 5099: 5095: 5091: 5085: 5070: 5066: 5060: 5044: 5040: 5036: 5030: 5011: 5007: 5005: 4996: 4990: 4988: 4971: 4967: 4960: 4958: 4956: 4939: 4935: 4929: 4925: 4924: 4916: 4914: 4897: 4893: 4889: 4883: 4881: 4872: 4868: 4864: 4860: 4856: 4852: 4848: 4844: 4837: 4835: 4833: 4816: 4812: 4808: 4804: 4798: 4794: 4790: 4783: 4781: 4779: 4770: 4766: 4761: 4756: 4752: 4748: 4744: 4740: 4736: 4729: 4727: 4725: 4723: 4721: 4719: 4710: 4706: 4702: 4696: 4692: 4688: 4684: 4677: 4675: 4673: 4671: 4651: 4647: 4643: 4639: 4635: 4631: 4627: 4623: 4619: 4612: 4605: 4603: 4601: 4599: 4597: 4580: 4576: 4572: 4568: 4564: 4560: 4556: 4552: 4548: 4544: 4537: 4535: 4526: 4522: 4517: 4512: 4508: 4504: 4500: 4493: 4491: 4482: 4478: 4474: 4470: 4466: 4462: 4455: 4453: 4451: 4442: 4438: 4434: 4430: 4426: 4422: 4415: 4413: 4404: 4400: 4396: 4392: 4388: 4384: 4376: 4374: 4362: 4358: 4351: 4345: 4343: 4341: 4339: 4337: 4328: 4324: 4320: 4316: 4312: 4308: 4304: 4300: 4293: 4285: 4281: 4277: 4273: 4266: 4264: 4255: 4251: 4247: 4243: 4239: 4235: 4231: 4227: 4220: 4218: 4216: 4207: 4203: 4198: 4193: 4189: 4185: 4181: 4177: 4173: 4166: 4164: 4155: 4151: 4146: 4141: 4137: 4133: 4130:(2): 99–144. 4129: 4125: 4121: 4114: 4112: 4110: 4108: 4106: 4104: 4102: 4100: 4098: 4096: 4094: 4092: 4083: 4077: 4073: 4066: 4057: 4052: 4048: 4044: 4040: 4034: 4032: 4023: 4019: 4014: 4009: 4005: 4001: 3997: 3993: 3989: 3982: 3980: 3963: 3959: 3955: 3949: 3947: 3945: 3928: 3924: 3920: 3914: 3898: 3894: 3890: 3884: 3882: 3865: 3861: 3857: 3851: 3835: 3831: 3827: 3821: 3819: 3817: 3815: 3813: 3811: 3809: 3807: 3805: 3788: 3784: 3780: 3774: 3758: 3754: 3753: 3752:Health Canada 3748: 3742: 3726: 3722: 3721: 3720:Health Canada 3716: 3710: 3694: 3690: 3686: 3682: 3676: 3660: 3656: 3650: 3635: 3631: 3627: 3621: 3613: 3609: 3604: 3599: 3595: 3591: 3587: 3583: 3579: 3572: 3570: 3568: 3559: 3555: 3551: 3547: 3543: 3539: 3535: 3531: 3524: 3522: 3520: 3518: 3516: 3514: 3512: 3510: 3508: 3506: 3504: 3502: 3500: 3498: 3496: 3494: 3492: 3490: 3488: 3486: 3484: 3482: 3465: 3461: 3457: 3451: 3447: 3437: 3434: 3433: 3427: 3425: 3415: 3407: 3405: 3404:methcathinone 3401: 3400:narcotic drug 3391: 3377: 3373: 3371: 3368:In 2017, the 3366: 3362: 3358: 3356: 3351: 3347: 3344: 3339: 3334: 3331: 3327: 3323: 3319: 3318:Nariman Mehta 3311: 3306: 3266: 3258: 3257: 3254: 3251: 3247: 3245: 3240: 3236: 3232: 3231:propiophenone 3222: 3219: 3217: 3213: 3209: 3205: 3200: 3198: 3194: 3191: 3190:hydrochloride 3187: 3183: 3175: 3163: 3159: 3156: 3151: 3149: 3145: 3141: 3137: 3133: 3129: 3125: 3121: 3117: 3113: 3109: 3105: 3101: 3097: 3093: 3089: 3079: 3077: 3073: 3067: 3063: 3061: 3057: 3052: 3050: 3048: 3043: 3041: 3036: 3032: 3028: 3024: 3020: 3016: 3014: 3009: 3008: 3003: 2999: 2995: 2990: 2988: 2984: 2976: 2964: 2955: 2953: 2950: 2946: 2942: 2938: 2933: 2931: 2927: 2923: 2919: 2908: 2886: 2883: 2876: 2871: 2869: 2865: 2861: 2857: 2853: 2845: 2841: 2833: 2828: 2826: 2822: 2818: 2814: 2810: 2806: 2802: 2798: 2796: 2791: 2787: 2785: 2780: 2778: 2773: 2769: 2765: 2761: 2757: 2753: 2744: 2704: 2700: 2696: 2690: 2688:34,000–69,000 2687: 2682: 2677: 2676: 2672: 2666: 2663: 2661: 2655: 2654: 2650: 2644: 2641: 2639: 2629: 2628: 2624: 2618: 2616:12,000–14,000 2615: 2613: 2599: 2598: 2594: 2588: 2585: 2583: 2569: 2568: 2564: 2558: 2555: 2553: 2539: 2538: 2534: 2528: 2525: 2523: 2509: 2508: 2504: 2498: 2495: 2493: 2483: 2482: 2478: 2472: 2469: 2467: 2461: 2460: 2456: 2450: 2447: 2445: 2439: 2438: 2434: 2428: 2425: 2423: 2413: 2412: 2408: 2402: 2399: 2397: 2387: 2386: 2376: 2355: 2346: 2341: 2336: 2335: 2325: 2304: 2295: 2290: 2285: 2284: 2274: 2253: 2244: 2239: 2234: 2233: 2229: 2226: 2223: 2220: 2219: 2203: 2200: 2197: 2194: 2191: 2189: 2182: 2178: 2175: 2172: 2169: 2166: 2163: 2151: 2147: 2144: 2141: 2138: 2135: 2132: 2121: 2117: 2114: 2111: 2108: 2105: 2102: 2091: 2087: 2084: 2081: 2078: 2075: 2072: 2068: 2064: 2061: 2058: 2055: 2052: 2049: 2045: 2041: 2038: 2035: 2032: 2029: 2026: 2022: 2018: 2010: 2006: 2003: 2000: 1997: 1994: 1990: 1986: 1983: 1980: 1977: 1974: 1972:to bupropion 1969: 1965: 1960: 1957: 1951: 1945: 1939: 1933: 1927: 1921: 1915: 1904: 1893: 1891: 1887: 1882: 1880: 1876: 1872: 1868: 1864: 1860: 1855: 1853: 1849: 1845: 1844:nortriptyline 1841: 1837: 1833: 1829: 1825: 1822: 1818: 1814: 1810: 1806: 1802: 1797: 1795: 1791: 1787: 1783: 1782:phenobarbital 1779: 1775: 1771: 1767: 1763: 1762:carbamazepine 1759: 1755: 1751: 1747: 1743: 1739: 1738:norfluoxetine 1735: 1731: 1727: 1723: 1713: 1711: 1707: 1703: 1699: 1695: 1691: 1681: 1679: 1674: 1671: 1666: 1664: 1660: 1655: 1652: 1648: 1647:boxed warning 1638: 1636: 1631: 1629: 1624: 1622: 1618: 1613: 1611: 1607: 1602: 1599: 1595: 1593: 1588: 1586: 1579: 1569: 1567: 1563: 1560:, and severe 1559: 1555: 1551: 1547: 1543: 1539: 1535: 1531: 1521: 1512:(Auvelity; 45 1511: 1499: 1495: 1470: 1466: 1463: 1462:hydrochloride 1459: 1456: 1450: 1446: 1436: 1434: 1429: 1427: 1423: 1422:animal models 1419: 1415: 1411: 1407: 1403: 1399: 1394: 1392: 1388: 1384: 1373: 1371: 1367: 1363: 1359: 1348: 1346: 1345:meta-analysis 1342: 1338: 1334: 1330: 1326: 1316: 1314: 1310: 1306: 1302: 1298: 1294: 1290: 1280: 1276: 1274: 1270: 1265: 1261: 1258: 1254: 1244: 1242: 1236: 1233: 1229: 1225: 1219: 1217: 1213: 1208: 1205: 1201: 1196: 1192: 1191:meta-analyses 1189:is low. Some 1188: 1184: 1180: 1179:effectiveness 1168:Wellbutrin XL 1166: 1157: 1155: 1147: 1143: 1142:Nariman Mehta 1138: 1136: 1132: 1128: 1124: 1120: 1116: 1112: 1109:(NDRI) and a 1108: 1103: 1101: 1097: 1093: 1089: 1085: 1081: 1077: 1073: 1069: 1065: 1061: 1057: 1053: 1049: 1045: 1041: 1036: 1034: 1029: 1025: 1021: 1017: 1013: 1009: 1005: 1001: 997: 993: 983: 976: 967: 962: 961: 958: 951: 942: 941: 938: 931: 924: 920: 919: 917: 914: 909: 902: 900: 896: 872: 870: 866: 861: 853: 849: 848:DTXSID7022706 845: 844: 842: 833: 829: 822: 818: 817: 815: 813: 809: 802: 798: 797: 795: 793: 789: 782: 778:as HCl: 777: 774: 770: 769: 767: 765: 761: 754: 750: 749: 747: 745: 741: 734: 730: 729: 727: 725: 721: 714: 710: 709: 707: 705: 701: 694: 690: 689: 687: 685: 681: 674: 670: 669: 667: 660: 656: 649: 643: 637: 633: 632: 630: 628: 624: 616: 612: 607: 606: 603: 596: 591: 587: 570: 567: 565: 561: 519: 517: 510: 501: 493: 485: 478: 476: 472: 468: 464: 460: 457: 455: 451: 443: 441: 437: 433: 431: 427: 423: 419: 412: 410: Rx-only 403: 400: 388: 385: 375: 373: 364: 361: 351: 348: 338: 337: 335: 333: 329: 324: 316: 311: 308: 307: 305: 303: 299: 296: 293: 290: 288: 284: 280: 277: 275: 269: 263: 254: 253: 251: 249: 243: 236: 231: 222: 221: 219: 217: 213: 209: 205: 203: 199: 195: 191: 189: 185: 181: 177: 173: 167: 163: 157: 153: 149: 145: 141: 139: 135: 131: 130: 121: 120: 109: 68: 66:Pronunciation 64: 61:Clinical data 59: 52: 47: 43: 38: 30: 26: 22: 21:Buprenorphine 27436:Aphrodisiacs 27366: 27342:Side Effects 27340: 27312: 27305: 27298: 27291: 27284: 27260:Andrew Witty 27245:Mahlon Kline 27196:Vivienne Cox 27009: 26965:H5N1 vaccine 26892: 26882: 26726:acquisitions 26664:Subsidiaries 26595:Solriamfetol 26510:Famprofazone 26416: 26408: 26394:-Octopamine) 26391: 26388:Norfenefrine 26343:Metanephrine 26335: 26291:Isoprenaline 26247:(Dextrodopa) 26232:Adrenochrome 26190:Pyrovalerone 26096: 26075: 26034:Entactogens: 26033: 25983:Entactogens: 25982: 25929:Ethcathinone 25913: 25845: 25824: 25813:Entactogens: 25812: 25775: 25768:Phentermines 25731: 25580:Entactogens: 25579: 25576:Zylofuramine 25354:Fenfluramine 25349:Fenethylline 25299:Amphetaminil 25280:Amfepentorex 25241: 25099: 25092:Amphetamines 25073: 25057:Entactogens: 25056: 25042: 25034: 25026: 25018: 24982: 24980: 24956:Metaescaline 24558: 24498: 24497: 24452:Promethazine 24437:Perphenazine 24417:Fluphenazine 24392:Clocapramine 24367:Carvotroline 24343: 24333: 24269:Antagonists: 24268: 24228: 24104: 24055:Antagonists: 24054: 23956: 23828:Clomipramine 23764: 23749: 23742: 23721:Progesterone 23608:Antagonists: 23607: 23571:Pregnenolone 23458:Escitalopram 23378:Cloperastine 23353:Blarcamesine 23309: 23242: 23233: 23220: 23211: 23202: 23193: 23182: 23181: 23137: 23125:Vortioxetine 23111:fluphenazine 23085:clomipramine 22980:JNJ-18038683 22970:methysergide 22881:fluperlapine 22861:aripiprazole 22850:Antagonists: 22849: 22814:frovatriptan 22746: 22687: 22652:clomipramine 22560:Landipirdine 22550:Idalopirdine 22535:Cerlapirdine 22482:fluperlapine 22466:aripiprazole 22454:Antagonists: 22453: 22362:methysergide 22326: 22287:methysergide 22275: 22246:Antagonists: 22245: 22196: 22130:Antagonists: 22129: 22072:Prucalopride 22018: 21976: 21954:Vortioxetine 21868:Palonosetron 21812: 21757:Antagonists: 21756: 21634: 21566: 21548:thioridazine 21384:Medifoxamine 21339:methysergide 21291:Deramciclane 21245:paliperidone 21229:fluperlapine 21200:Antagonists: 21199: 21079:aripiprazole 20962:ergine (LSA) 20805: 20768: 20673:Sarpogrelate 20523:aripiprazole 20507:Antagonists: 20506: 20383:methysergide 20318:fenfluramine 20302:Amphetamines 20288: 20247: 20225:Volinanserin 20211:thioridazine 20183:perphenazine 20171:fluphenazine 20113:Teniloxazine 20064:Sarpogrelate 20054:Roluperidone 20024:Pimavanserin 20004:Nelotanserin 19979:Medifoxamine 19964:Landipirdine 19924:methysergide 19895:Eplivanserin 19885:Deramciclane 19840:paliperidone 19808:fluperlapine 19796:clocapramine 19792:carpipramine 19776:aripiprazole 19721:5-MeO-NBpBrT 19713:Antagonists: 19712: 19485:ergine (LSA) 19307:2CBFly-NBOMe 19266: 19214:Antagonists: 19213: 19157:methysergide 19128: 19084: 19069:Antagonists: 19068: 19030:methysergide 19017: 18967: 18872:Antagonists: 18871: 18828:zolmitriptan 18812:frovatriptan 18746:methysergide 18703: 18658: 18554:Antagonists: 18553: 18541:Vortioxetine 18508:zolmitriptan 18463:methysergide 18404: 18357: 18325:Spiroxatrine 18144:Antagonists: 18143: 17894:methysergide 17811:tandospirone 17757:aripiprazole 17747:vortioxetine 17700: 17490:Tubocurarine 17420:Promegestone 17415:Progesterone 17330:Mecamylamine 17140:Cyclopropane 17130:Coronaridine 17094: 17062:Barbiturates 17047:Anatruxonium 17017:α-cobratoxin 16860:Sazetidine A 16780:JNJ-39393406 16770:Ispronicline 16481: 16480: 16465: 16453: 16450: 16440: 16350:Bietaserpine 16322:Amphetamines 16245:Mifepristone 16235:Medifoxamine 16117: 16060:Clomipramine 16055:Cianopramine 16046: 15899:Diclofensine 15869:Brasofensine 15845: 15769: 15757:Vortioxetine 15708: 15627:Escitalopram 15583: 15505:Indeloxazine 15497: 15434: 15417:Oxaprotiline 15398: 15386:Trimipramine 15341:Clomipramine 15336:Cianopramine 15331:Butriptyline 15322: 15175:Diclofensine 15145:Brasofensine 15121: 15045: 15033:Solriamfetol 14967: 14959: 14942:Teniloxazine 14902:Esreboxetine 14873: 14805:Solriamfetol 14725:Medifoxamine 14615:Dimethocaine 14605:Diclofensine 14577: 14572: 14529: 14417:Difluoropine 14412:Dichloropane 14397:Brasofensine 14383: 14371:Pyrovalerone 14347: 14272:Piperidines: 14271: 14221:Piperazines: 14220: 14136: 14135: 14119: 14102: 14085:amphetamines 14076:Phentolamine 14030: 14002:acecarbromal 13970:progesterone 13966:Progestogens 13930:testosterone 13918:Sex steroids 13830:Melanotan II 13518:+semaglutide 13514:Cagrilintide 13470:Orforglipron 13340:Pyrovalerone 13289:+phentermine 13285:Fenfluramine 13280:Fenbutrazate 13254: 13166:Zylofuramine 13101:Fenethylline 13031:Amphetaminil 13016:Amfepentorex 12993:Amphetamines 12919:Barbiturates 12917: 12890: 12873: 12843: 12794: 12767: 12727: 12703: 12689: 12657: 12627: 12618:Mecamylamine 12602: 12484:Oxitriptan ( 12476: 12360:aripiprazole 12318: 12267:Metralindole 12258: 12228: 12218: 12197:Pivhydrazine 12187:Pheniprazine 12133: 12039:Trimipramine 12029:Quinupramine 11929:Clomipramine 11924:Butriptyline 11847:Teniloxazine 11842:Tandospirone 11827:Metryptamine 11822:Medifoxamine 11807:Indeloxazine 11761:Vortioxetine 11661: 11523:Escitalopram 11410: 11406: 11396: 11371: 11367: 11361: 11336: 11332: 11326: 11307: 11301: 11289:. Retrieved 11280: 11271: 11252: 11246: 11238: 11231:. Retrieved 11213: 11180: 11176: 11170: 11145: 11141: 11135: 11105:(1): 65–69. 11102: 11098: 11092: 11073: 11046: 11042: 11036: 11003: 10999: 10978:. Retrieved 10969: 10959: 10947:. Retrieved 10938: 10929: 10917:. Retrieved 10905: 10892: 10880:. Retrieved 10871: 10861: 10849:. Retrieved 10840: 10830: 10818:. Retrieved 10814:the original 10805: 10796: 10784:. Retrieved 10777:the original 10772: 10768: 10756: 10744:. Retrieved 10740:the original 10726: 10714:. Retrieved 10701: 10692: 10680:. Retrieved 10661: 10639:. Retrieved 10604:. Retrieved 10600:the original 10593: 10584: 10572:. Retrieved 10568:the original 10561: 10551: 10539:. Retrieved 10535:the original 10525: 10513:. Retrieved 10509:the original 10499: 10487:. Retrieved 10471: 10459: 10447:. Retrieved 10434: 10425: 10413:. Retrieved 10400: 10391: 10379:. Retrieved 10375:the original 10370: 10366: 10341:. Retrieved 10327: 10315:. Retrieved 10311:the original 10301: 10279:(11): 1479. 10276: 10272: 10266: 10231: 10227: 10217: 10190: 10186: 10176: 10144:(1): 53–54. 10141: 10137: 10127: 10115:. Retrieved 10100: 10093: 10081:. Retrieved 10076: 10052:. Retrieved 10048: 10011: 10007: 10001: 9976: 9972: 9966: 9941: 9937: 9903: 9899: 9855: 9833: 9816: 9812: 9806: 9781: 9777: 9770: 9750: 9743: 9731:. Retrieved 9709:(6): 903–7. 9706: 9702: 9656: 9652: 9618: 9614: 9607: 9575:(1): 142–5. 9572: 9568: 9558: 9525: 9521: 9515: 9482: 9478: 9472: 9448:(4): 251–7. 9445: 9441: 9431: 9396: 9392: 9370: 9350: 9346: 9340: 9315: 9311: 9305: 9268: 9264: 9254: 9232:(1): 81–92. 9229: 9225: 9218: 9209: 9189: 9185: 9151: 9147: 9101: 9097: 9049: 9045: 9039: 9004: 9000: 8990: 8965: 8961: 8939: 8914: 8910: 8903: 8878: 8874: 8868: 8843: 8839: 8833: 8808: 8804: 8798: 8773: 8769: 8763: 8746: 8742: 8736: 8724:. Retrieved 8720: 8696:. Retrieved 8692: 8667:. Retrieved 8662: 8607: 8603: 8593: 8558: 8554: 8544: 8511: 8507: 8475:(1): 85–93. 8472: 8468: 8462: 8429: 8425: 8379: 8375: 8323: 8319: 8313: 8278: 8274: 8264: 8239: 8235: 8229: 8204: 8200: 8194: 8169:11585/762375 8151: 8147: 8102: 8098: 8088: 8061: 8057: 8047: 8035:. Retrieved 8023: 7981: 7977: 7971: 7946: 7942: 7890: 7886: 7876: 7857: 7851: 7816: 7812: 7802: 7790:. Retrieved 7786:the original 7736:(2): 92–97. 7733: 7729: 7719: 7702: 7698: 7692: 7660:(1): 12–28. 7657: 7653: 7643: 7610: 7606: 7600: 7575: 7571: 7564: 7529: 7525: 7515: 7482: 7478: 7472: 7460:. Retrieved 7427: 7423: 7413: 7383:(1): 63–74. 7380: 7376: 7369: 7359:20 September 7357:. Retrieved 7348: 7339: 7329:20 September 7327:. Retrieved 7277: 7273: 7267: 7242: 7238: 7232: 7207: 7203: 7197: 7188: 7175: 7128: 7124: 7114: 7077: 7073: 7063: 7036: 7032: 7022: 6985: 6981: 6971: 6946: 6942: 6935: 6910: 6906: 6900: 6868:(2): 28–35. 6865: 6861: 6851: 6839:. Retrieved 6830: 6821: 6809:. Retrieved 6796: 6787: 6760: 6756: 6700: 6696: 6686: 6659: 6655: 6645: 6613:(2): 59–74. 6610: 6606: 6596: 6561: 6557: 6547: 6512: 6508: 6498: 6465: 6461: 6455: 6420: 6416: 6378: 6374: 6368: 6333: 6329: 6319: 6274: 6270: 6260: 6225: 6221: 6211: 6176: 6172: 6162: 6135: 6131: 6121: 6094: 6090: 6080: 6045: 6041: 6031: 5996: 5992: 5982: 5949: 5945: 5897: 5893: 5883: 5848: 5844: 5797:(1): 45–53. 5794: 5790: 5780: 5743: 5739: 5729: 5694: 5690: 5680: 5647: 5643: 5621:. Retrieved 5617:the original 5612: 5608: 5598: 5563: 5559: 5549: 5514: 5510: 5500: 5473: 5470:N Engl J Med 5469: 5459: 5422: 5418: 5408: 5373: 5369: 5311: 5307: 5257: 5253: 5226:. Retrieved 5180: 5176: 5123: 5119: 5112: 5103:10665/371090 5093: 5084: 5072:. Retrieved 5068: 5059: 5047:. Retrieved 5038: 5029: 5017:. Retrieved 5001: 4974:. Retrieved 4942:. Retrieved 4922: 4900:. Retrieved 4891: 4846: 4843:J Addict Dis 4842: 4819:. Retrieved 4792: 4742: 4738: 4682: 4657:. Retrieved 4621: 4617: 4583:. Retrieved 4550: 4546: 4506: 4502: 4464: 4460: 4424: 4420: 4386: 4382: 4361:the original 4302: 4298: 4292: 4275: 4271: 4229: 4225: 4179: 4175: 4127: 4123: 4071: 4065: 4046: 4042: 3995: 3991: 3966:. Retrieved 3957: 3931:. Retrieved 3922: 3913: 3901:. Retrieved 3892: 3868:. Retrieved 3859: 3850: 3838:. Retrieved 3829: 3791:. Retrieved 3782: 3773: 3761:. Retrieved 3750: 3741: 3729:. Retrieved 3718: 3709: 3697:. Retrieved 3675: 3663:. Retrieved 3649: 3637:. Retrieved 3629: 3620: 3585: 3581: 3533: 3529: 3468:. Retrieved 3459: 3450: 3421: 3413: 3397: 3394:Legal status 3388: 3374: 3367: 3363: 3359: 3352: 3348: 3335: 3315: 3310:steady-state 3243: 3237:followed by 3228: 3220: 3202:A number of 3201: 3197:hydrobromide 3152: 3139: 3135: 3123: 3119: 3115: 3111: 3107: 3103: 3085: 3068: 3064: 3053: 3046: 3039: 3012: 3006: 2991: 2969: 2934: 2922:amphetamines 2872: 2829: 2809:β-adrenergic 2803:, including 2794: 2783: 2776: 2749: 2742: 2702: 2642:7,900–50,000 2496:7,600–28,000 2400:4,200–16,000 2296:3,640–52,000 1949: 1937: 1925: 1913: 1896:Pharmacology 1883: 1871:theophylline 1856: 1798: 1766:clotrimazole 1754:orphenadrine 1719: 1716:Interactions 1687: 1675: 1673:medication. 1667: 1656: 1644: 1632: 1625: 1614: 1603: 1596: 1592:hypertension 1589: 1581: 1572:Side effects 1562:hypertension 1527: 1500:(Contrave; 8 1494:combinations 1469:hydrobromide 1452: 1430: 1416:and improve 1395: 1379: 1354: 1322: 1286: 1277: 1266: 1262: 1250: 1241:aripiprazole 1237: 1220: 1209: 1176: 1160:Medical uses 1139: 1104: 1056:constipation 1037: 999: 996:amfebutamone 995: 991: 990: 979: 646:905818-69-1 640:31677-93-7 ( 614: 610: 513:Elimination 332:Legal status 326:Legal status 216:License data 175: 171: 165: 161: 155: 151: 29: 27456:Dermatoxins 27209:Judy Lewent 26615:Venlafaxine 26580:Pronethalol 26550:Methoxamine 26480:Dizocilpine 26475:Diphenidine 26450:Amidephrine 26411:-Octopamine 26348:Metaraminol 26315:(Droxidopa) 26261:Epinephrine 26251:Dimetofrine 26097:Stimulants: 26076:Stimulants: 25904:Brephedrone 25894:Amfepramone 25846:Stimulants: 25828:Cericlamine 25809:Phentermine 25789:Clortermine 25776:Stimulants: 25556:Sibutramine 25541:Prenylamine 25476:Oxifentorex 25428:Metaraminol 25368:Fenproporex 25339:Fencamfamin 25319:Clobenzorex 25285:Amphetamine 25242:Stimulants: 24983:Stimulants: 24941:Macromerine 24487:Venlafaxine 24467:Remoxipride 24457:Propranolol 24382:Cinnarizine 24282:Lamotrigine 24178:Pentazocine 24173:Noribogaine 24163:Nemonapride 23995:Haloperidol 23921:Spipethiane 23886:Noribogaine 23881:Nemonapride 23876:KCR-12-83.1 23716:Pentazocine 23676:Haloperidol 23581:Pridopidine 23556:Pentazocine 23473:Fluvoxamine 23393:Cyclazocine 23195:Adrenergics 23155:Piperazines 23071:mirtazapine 23063:maprotiline 22974:sergolexole 22966:metergoline 22962:mesulergine 22942:cabergoline 22921:EGIS-12,233 22901:ziprasidone 22889:risperidone 22873:clorotepine 22857:amisulpride 22820:Tryptamines 22713:Piperazines 22570:Masupirdine 22540:EGIS-12,233 22486:iloperidone 22474:clorotepine 22378:Tryptamines 22358:metergoline 22354:mesulergine 22293:Piperazines 22283:metergoline 22223:Tryptamines 22107:Usmarapride 22062:Minesapride 22037:Cinitapride 21985:Piperazines 21944:sevoflurane 21921:Tropisetron 21916:Tropanserin 21905:mirtazapine 21863:Ondansetron 21843:Granisetron 21818:Cilansetron 21803:Batanopride 21770:Arazasetron 21765:Anpirtoline 21704:Tryptamines 21666:Piperazines 21544:pipamperone 21493:mirtazapine 21485:maprotiline 21459:SDZ SER-082 21409:Propranolol 21399:Pirenperone 21349:Etoperidone 21343:sergolexole 21335:metergoline 21331:mesulergine 21306:Eltoprazine 21261:ziprasidone 21253:risperidone 21233:iloperidone 21221:clorotepine 21208:Agomelatine 21203:Adatanserin 21172:Vabicaserin 21126:Tryptamines 21075:Piperazines 20954:cabergoline 20730:mirtazapine 20708:SDZ SER-082 20658:Rauwolscine 20648:Propranolol 20638:Pirenperone 20607:mesulergine 20567:ziprasidone 20563:risperidone 20555:pipamperone 20535:cariprazine 20519:amisulpride 20510:Agomelatine 20445:Tryptamines 20420:Piperazines 20363:cabergoline 20259:nicergoline 20215:thiothixene 20191:pipamperone 20175:haloperidol 20147:mirtazapine 20139:maprotiline 20085:mepiprazole 20073:etoperidone 20044:Rauwolscine 20039:Pruvanserin 20029:Pirenperone 19944:Glemanserin 19939:Flibanserin 19928:sergolexole 19920:metergoline 19916:mesulergine 19860:ziprasidone 19856:zicronapine 19848:risperidone 19832:ocaperidone 19828:mosapramine 19816:iloperidone 19812:gevotroline 19800:clorotepine 19784:blonanserin 19749:hydroxyzine 19731:Adatanserin 19659:Tryptamines 19626:Piperazines 19481:cabergoline 19299:2CBCB-NBOMe 19295:25TFM-NBOMe 19196:Tryptamines 19190:sumatriptan 19186:naratriptan 19051:Tryptamines 18971:Acetryptine 18955:Ziprasidone 18894:metergoline 18834:Tryptamines 18824:sumatriptan 18820:rizatriptan 18816:naratriptan 18804:donitriptan 18796:almotriptan 18730:cabergoline 18666:cabergoline 18605:metergoline 18586:propranolol 18519:Tryptamines 18504:sumatriptan 18496:donitriptan 18438:Eltoprazine 18408:Anpirtoline 18361:Acetryptine 18310:SDZ 216-525 18250:Flopropione 18239:metergoline 18210:propranolol 18155:risperidone 18151:iloperidone 18064:Tryptamines 18009:Rauwolscine 17999:Pardoprunox 17939:Flibanserin 17870:cabergoline 17857:Enciprazine 17852:Eltoprazine 17832:Cannabidiol 17807:perospirone 17785:ziprasidone 17769:cariprazine 17723:etoperidone 17714:Amphetamine 17709:Adatanserin 17595:Pirisudanol 17560:Cyprodenate 17540:Adafenoxate 17455:Surugatoxin 17445:Sevoflurane 17400:Pentolinium 17380:Norketamine 17300:Laudanosine 17230:Erythravine 17220:Encenicline 17205:Dipyrandium 17175:Dextrorphan 17021:α-conotoxin 16980:Antagonists 16965:WAY-317,538 16960:Varenicline 16950:Tropisetron 16940:Tebanicline 16885:SSR-180,711 16850:Rivanicline 16840:Pozanicline 16835:PNU-282,987 16830:PNU-120,596 16825:PHA-709,829 16820:PHA-543,613 16760:Galantamine 16735:Epiboxidine 16730:Epibatidine 16650:Altinicline 16493:Adrenergics 16420:Valbenazine 16410:Rose bengal 16355:Deserpidine 16326:amphetamine 16276:levorphanol 16220:Dextrorphan 16173:ziprasidone 16155:pheniramine 16090:Lofepramine 16070:Desipramine 16019:Tesofensine 16009:Sibutramine 15984:Perafensine 15944:JNJ-7925476 15939:Indatraline 15884:Dasotraline 15854:Amifitadine 15833:Venlafaxine 15813:Milnacipran 15712:Etoperidone 15692:Seproxetine 15682:Pirandamine 15662:Omiloxetine 15642:Fluvoxamine 15602:Cericlamine 15592:Alaproclate 15539:levorphanol 15468:ziprasidone 15450:pheniramine 15422:Setiptiline 15407:Maprotiline 15366:Lofepramine 15346:Desipramine 15295:Tesofensine 15285:Sibutramine 15260:Perafensine 15220:JNJ-7925476 15215:Indatraline 15160:Dasotraline 15130:Amifitadine 15109:Venlafaxine 15084:Milnacipran 15013:Nomifensine 14978:Fencamfamin 14907:Lortalamine 14897:Edivoxetine 14887:Ciclazindol 14882:Alseroxylon 14830:Venlafaxine 14810:Tametraline 14800:Sibutramine 14775:Perafensine 14755:Nomifensine 14685:Indatraline 14660:Fencamfamin 14635:DOV-216,303 14630:DOV-102,677 14590:Dasotraline 14585:Ciclazindol 14543:Armodafinil 14538:Amifitadine 14487:Tesofensine 14295:Difemetorex 14099:Rauwolscine 14056:Mirtazapine 14051:Flibanserin 14021:Alprostadil 13878:Mirodenafil 13792:Quinagolide 13787:Pramipexole 13767:Cabergoline 13762:Apomorphine 13685:from market 13634:Metreleptin 13570:Mitratapide 13565:Dirlotapide 13495:Tirzepatide 13485:Semaglutide 13480:Retatrutide 13465:Liraglutide 13454:Ecnoglutide 13449:Danuglipron 13379:Ibipinabant 13366:antagonists 13364:Cannabinoid 13350:Tesofensine 13345:Sibutramine 13275:Difemetorex 13259:+naltrexone 13245:Atomoxetine 13214:Terbutaline 13189:Clenbuterol 13155:+topiramate 13151:Phentermine 13106:Fenproporex 13066:Clortermine 13056:Clobenzorex 13026:Amphetamine 13021:Amfepramone 12673:Acamprosate 12623:Varenicline 12523:from market 12466:brexanolone 12380:risperidone 12277:Moclobemide 12259:Reversible: 12219:Reversible: 12142:Iproclozide 12077:Setiptiline 12072:Mirtazapine 12062:Maprotiline 12019:Propizepine 12004:Noxiptiline 11989:Metapramine 11979:Lofepramine 11949:Dimetacrine 11939:Desipramine 11812:Flupentixol 11797:Etryptamine 11782:Amisulpride 11777:Agomelatine 11723:Etoperidone 11700:Setiptiline 11695:Mirtazapine 11667:Nomifensine 11624:Atomoxetine 11601:Venlafaxine 11591:Milnacipran 11533:Fluvoxamine 10919:26 November 10882:26 November 10851:26 February 10820:20 December 10786:16 December 10045:"Bupropion" 9938:Xenobiotica 7607:Drug Safety 7462:13 November 7349:AdisInsight 7097:10852/63759 6913:: 129–135. 5376:: e067606. 5228:13 December 5183:: 393–398. 4888:"Bupropion" 4547:Drug Safety 4056:10665/58135 3470:24 December 3410:Brand names 3246:-butylamine 3172:ClNO and a 3132:enantiomers 3088:aminoketone 3076:reinforcing 3004:leading to 3000:isoenzymes 2762:of several 2758:(NDRI) and 2302:1,400–1,900 2192:87 (mouse) 2012:Inhibition 1848:venlafaxine 1824:dextrorphan 1813:atomoxetine 1809:desipramine 1794:Ticlopidine 1750:clopidogrel 1694:venlafaxine 1641:Psychiatric 1358:sibutramine 1351:Weight gain 1309:amphetamine 1297:atomoxetine 1273:varenicline 1232:hypersomnia 1204:unpublished 1200:variability 1195:effect size 1119:aminoketone 1028:hypersomnia 906: g·mol 593:Identifiers 475:Metabolites 202:MedlinePlus 147:Other names 138:Trade names 27506:Stimulants 27446:Cathinones 27421:Anorectics 27405:Categories 27278:Litigation 27265:Chris Gent 27214:Urs Rohner 27122:Parodontax 26930:Engerix-B 26743:Block Drug 26585:Salbutamol 26520:Hexapradol 26500:Etafedrine 26495:Ephenidine 26490:Dopexamine 26485:Dobutamine 26465:Denopamine 26455:Arbutamine 26429:Synephrine 26363:Methyldopa 26358:Metirosine 26306:(Levodopa) 26296:Isoetarine 26281:Fenclonine 26271:Etilefrine 26185:Prolintane 26016:Mephedrone 25979:Radafaxine 25969:Pentedrone 25949:Methedrone 25909:Buphedrone 25899:Benzedrone 25838:Cathinones 25750:Selegiline 25740:Amiflamine 25536:Pholedrine 25486:Ortetamine 25481:Oxilofrine 25413:Lefetamine 25403:Iofetamine 25388:Furfenorex 25383:Formetorex 25373:Flucetorex 25304:Benfluorex 25275:Amfecloral 25270:Alfetamine 25143:D-Deprenyl 25060:Lophophine 24971:Psi-2C-T-4 24966:Proscaline 24936:Jimscaline 24472:SL 82.0715 24387:Cinuperone 24362:Caramiphen 24357:Butaclamol 24257:Tapentadol 24188:Safinamide 24168:Nepinalone 24133:Clemastine 24128:5-MeO-DiPT 24123:5-MeO-DALT 24000:Ifenprodil 23965:Arketamine 23916:Selegiline 23911:Safinamide 23871:Imipramine 23833:Clorgiline 23823:Clemastine 23813:Azidopamil 23803:5-MeO-DiPT 23798:5-MeO-DALT 23731:Sertraline 23531:Nepinalone 23478:Ifenprodil 23468:Fluoxetine 23433:Dimemorfan 23402:prasterone 23363:Citalopram 23358:Captodiame 23338:Arketamine 23333:Amantadine 23291:modulators 23089:imipramine 23050:SSR-181507 23025:SB-656104A 23000:Ritanserin 22990:LY-215,840 22985:Ketanserin 22958:LY-215,840 22950:ergotamine 22934:amesergide 22911:Butaclamol 22897:tiospirone 22893:sertindole 22885:olanzapine 22760:Bifeprunox 22703:lergotrile 22600:Ro 63-0563 22595:Ro 04-6790 22590:Ritanserin 22555:Ketanserin 22494:tiospirone 22490:olanzapine 22441:WAY-208466 22436:WAY-181187 22430:tryptamine 22410:EMD-386088 22342:ergotamine 22264:Ritanserin 22208:ergotamine 22112:Velusetrag 22082:Renzapride 21964:Zatosetron 21883:Ricasetron 21878:Renzapride 21873:Ramosetron 21853:Lerisetron 21833:Dolasetron 21792:quetiapine 21788:olanzapine 21730:isoflurane 21554:Xylamidine 21477:aptazapine 21414:Ritanserin 21394:Nefazodone 21369:Ketanserin 21364:Irindalone 21354:Fluoxetine 21327:LY-215,840 21315:amesergide 21301:Dotarizine 21281:Cinanserin 21271:Captodiame 21257:sertindole 21249:quetiapine 21241:olanzapine 21182:WAY-161503 21166:tryptamine 21162:psilocybin 21106:PNU-181731 21065:lophophine 21051:Oxaflozane 21009:Lorcaserin 21004:Flumexadol 20966:ergotamine 20847:5-MeO-DiPT 20663:Ritanserin 20628:Metadoxine 20613:Ketanserin 20587:amesergide 20559:quetiapine 20551:olanzapine 20493:tryptamine 20489:psilocybin 20393:Lorcaserin 20375:ergotamine 20230:Xylamidine 20199:setoperone 20131:aptazapine 20118:Temanogrel 20089:nefazodone 20081:lubazodone 20049:Ritanserin 20014:Pelanserin 19954:Ketanserin 19949:Irindalone 19934:Fananserin 19912:LY-215,840 19904:amesergide 19890:Dotarizine 19875:Cinanserin 19852:sertindole 19844:quetiapine 19836:olanzapine 19820:lurasidone 19772:amperozide 19736:Altanserin 19716:5-I-R91150 19699:tryptamine 19695:psilocybin 19616:lophophine 19597:PNU-181731 19582:Oxaflozane 19550:Lorcaserin 19545:Jimscaline 19535:Flumexadol 19493:ergotamine 19361:5-MeO-DiPT 19182:eletriptan 19163:Lasmiditan 19137:CP-122,288 19055:tryptamine 19045:eletriptan 18945:Ritanserin 18905:Ketanserin 18880:BRL-15,572 18808:eletriptan 18800:avitriptan 18777:PNU-142633 18772:PNU-109291 18738:ergotamine 18707:CP-122,288 18616:Isamoltane 18590:tertatolol 18582:penbutolol 18578:oxprenolol 18574:isamoltane 18566:alprenolol 18557:AR-A000002 18500:eletriptan 18492:avitriptan 18455:ergotamine 18428:CP-122,288 18413:CGS-12066A 18366:Carvedilol 18345:Xylamidine 18340:WAY-100635 18335:WAY-100135 18305:SB-649,915 18295:Robalzotan 18260:Isamoltane 18230:Dotarizine 18214:tertatolol 18198:penbutolol 18194:oxprenolol 18190:isamoltane 18174:alprenolol 18159:sertindole 18126:Xaliproden 18121:Vilazodone 18111:U-92,016-A 18100:psilocybin 18088:indorenate 18059:Sunepitron 18054:SSR-181507 18004:Piclozotan 17994:Oxaflozane 17989:Osemozotan 17954:Lesopitron 17944:Flumexadol 17934:Flesinoxan 17878:ergotamine 17817:Bay R 1531 17799:eptapirone 17791:Azapirones 17781:quetiapine 17777:lurasidone 17743:vilazodone 17731:nefazodone 17666:modulators 17555:Citicoline 17535:Acetyl-coA 17519:Precursors 17495:Vanoxerine 17485:Tropeinium 17470:Toxiferine 17435:Reboxetine 17425:Radafaxine 17370:Neramexane 17360:Mivacurium 17355:Metocurine 17320:Malouetine 17285:Isoflurane 17240:Fazadinium 17235:Esketamine 17215:Doxacurium 17200:Dioscorine 17160:Desflurane 17125:Coclaurine 17057:Atracurium 17042:Amantadine 17032:Alcuronium 16785:Levamisole 16775:Ivermectin 16720:Dianicline 16680:Butinoline 16665:Anatoxin-a 16554:modulators 16469:SoRI-20041 16462:SoRI-20040 16390:Ketanserin 16317:Amiodarone 16280:tapentadol 16240:Mesembrine 16210:Delucemine 16187:esketamine 16100:Pipofezine 16085:Imipramine 16004:SEP-228432 15999:SEP-228431 15969:Nefazodone 15954:Liafensine 15924:Fezolamine 15914:DOV-216303 15909:DOV-102677 15864:Bicifadine 15859:Ansofaxine 15798:Eclanamine 15793:Duloxetine 15778:Bicifadine 15752:Vilazodone 15722:Lubazodone 15717:Litoxetine 15702:Zimelidine 15697:Sertraline 15672:Paroxetine 15667:Panuramine 15637:Fluoxetine 15632:Femoxetine 15612:Dapoxetine 15607:Citalopram 15531:tapentadol 15510:Nefazodone 15493:Ephenidine 15488:Dopexamine 15371:Melitracen 15361:Imipramine 15280:SEP-228432 15275:SEP-228431 15245:Nefazodone 15230:Liafensine 15200:Fezolamine 15190:DOV-216303 15185:DOV-102677 15140:Bicifadine 15135:Ansofaxine 15094:Nafenodone 15069:Eclanamine 15064:Duloxetine 15023:Radafaxine 15003:Manifaxine 14988:Lefetamine 14963:Amineptine 14947:Viloxazine 14922:Reboxetine 14917:Nisoxetine 14795:Sertraline 14785:Radafaxine 14770:Oroxylin A 14715:Manifaxine 14705:Liafensine 14695:Lefetamine 14675:GYKI-52895 14665:Fezolamine 14650:Esketamine 14645:Ephenidine 14568:BTS 74,398 14558:Ansofaxine 14553:Amineptine 14432:FP-β-CPPIT 14427:FE-β-CPPIT 14366:Prolintane 14259:Vanoxerine 14254:Nefazodone 14071:Papaverine 14061:Moxisylyte 14046:Dapoxetine 14026:Amantadine 13974:progestins 13908:Vardenafil 13888:Sildenafil 13858:Aildenafil 13802:Rotigotine 13797:Ropinirole 13659:Zonisamide 13649:Topiramate 13639:Naltrexone 13619:Bimagrumab 13590:Uncouplers 13580:Simmondsin 13560:Cetilistat 13544:Lorcaserin 13444:Cotadutide 13439:Cinchonine 13404:Taranabant 13399:Surinabant 13394:Rosonabant 13389:Rimonabant 13295:Manifaxine 13250:Benfluorex 13209:Synephrine 13116:Furfenorex 13011:Amfecloral 12984:Stimulants 12971:Anorectics 12850:Naltrexone 12784:Lofexidine 12723:Topiramate 12711:Naltrexone 12668:Disulfiram 12498:Tryptophan 12470:zuranolone 12376:quetiapine 12372:olanzapine 12368:lurasidone 12322:Selegiline 12312:-selective 12292:Toloxatone 12287:Tetrindole 12282:Pirlindole 12262:Eprobemide 12252:-selective 12232:Bifemelane 12222:Caroxazone 12182:Phenelzine 12167:Mebanazine 12147:Iproniazid 12034:Tianeptine 12014:Pipofezine 11984:Melitracen 11964:Imipramine 11944:Dibenzepin 11904:Amineptine 11852:Tianeptine 11837:Pivagabine 11832:Oxaflozane 11792:Esketamine 11756:Vilazodone 11728:Nefazodone 11657:Amineptine 11634:Viloxazine 11629:Reboxetine 11581:Duloxetine 11553:Zimelidine 11548:Sertraline 11543:Paroxetine 11528:Fluoxetine 11518:Citalopram 10980:24 October 10949:24 October 10574:13 October 10541:13 October 10489:21 October 10449:4 December 10415:4 December 9733:25 October 9659:: 173073. 9353:(2): 222. 9001:NeuroImage 8037:1 December 6222:Pediatrics 5746:(6): 116. 5691:CNS Spectr 4811:1249799493 3968:22 October 3903:21 October 3639:22 October 3442:References 3235:brominated 3216:manifaxine 3212:radafaxine 3182:lipophilic 3074:-like and 2224:Value (nM) 2164:nicotinic 2133:nicotinic 2103:nicotinic 2007:22 h 2004:31 h 2001:15 h 1998:19 h 1995:11 h 1992:Half-life 1909:Bupropion 1840:imipramine 1836:metoprolol 1832:heart rate 1821:metabolite 1770:rifampicin 1742:fluoxetine 1734:sertraline 1730:paroxetine 1576:See also: 1536:, such as 1496:including 1443:See also: 1376:Other uses 1307:, such as 1305:stimulants 1257:withdrawal 1224:sleepiness 1173:Depression 1024:sleepiness 1000:Wellbutrin 911:3D model ( 899:Molar mass 801:CHEBI:3219 753:01ZG3TPX31 724:ChemSpider 684:IUPHAR/BPS 636:34911-55-2 627:CAS Number 602:IUPAC name 583:unchanged) 520:Bupropion: 463:intestines 454:Metabolism 287:Drug class 27348:Study 329 27159:Directors 27157:Board of 27132:Sensodyne 27112:Nicorette 27069:Emergen-C 27064:ChapStick 27044:BC Powder 27039:Aquafresh 26980:Pandemrix 26950:Hepatyrix 26848:Flixonase 26828:Augmentin 26565:PARGY-LAD 26460:Cafedrine 26419:-Tyramine 26373:Nordefrin 26353:Metaterol 26338:-Tyramine 26330:-Tyrosine 26286:Ibopamine 26175:Naphyrone 26006:Methylone 25974:Pentylone 25919:Cathinone 25914:Bupropion 25757:-Deprenyl 25423:Mefenorex 25393:Gepefrine 25344:Fencamine 25329:Ephedrine 25265:Acridorex 24992:Hordenine 24951:Mescaline 24844:2C-T-22.5 24582:25N-NBOMe 24577:25I-NBOMe 24572:25D-NBOMe 24567:25C-NBOMe 24562:25B-NBOMe 24499:See also: 24477:SR-31747A 24462:Quinidine 24447:Proadifen 24432:Molindone 24407:Hypericin 24402:EMD-59983 24352:BMY-13980 24337:SKF-83959 24252:Naluzotan 24232:Berberine 24229:Agonists: 24183:RS-67,333 24118:4-MeO-PCP 24113:3-MeO-PCE 24028:Opipramol 24023:OPC-14523 23957:Agonists: 23896:RS-67,333 23841:-Deprenyl 23793:4-MeO-PCP 23773:3-MeO-PCP 23758:SOMCL-668 23750:Positive: 23746:Phenytoin 23736:SR-31742A 23711:PD-144418 23701:NPC-16377 23551:Opipramol 23546:OPC-14523 23541:Noscapine 23511:Memantine 23453:Eliprodil 23448:Donepezil 23323:5-MeO-DMT 23310:Agonists: 23183:See also: 23149:pergolide 23141:Ergolines 23067:mianserin 23059:amoxapine 23045:Spiperone 23030:SB-691673 23020:SB-656104 23015:SB-269970 23010:SB-258741 23005:SB-258719 22926:Ergolines 22877:clozapine 22865:asenapine 22836:N-Me-5-HT 22832:bufotenin 22800:Sarizotan 22795:RU-24,969 22770:Ergolines 22750:8-OH-DPAT 22747:Agonists: 22707:pergolide 22691:Ergolines 22638:mianserin 22634:amoxapine 22625:SB-742457 22620:SB-399885 22615:SB-357134 22610:SB-271046 22605:SB-258585 22585:PRX-07034 22545:GW-742457 22530:BVT-74316 22520:BGC20-760 22478:clozapine 22470:asenapine 22422:N-Me-5-HT 22418:LY-586713 22398:Bufotenin 22382:2-Me-5-HT 22330:Ergolines 22327:Agonists: 22279:Ergolines 22269:SB-699551 22249:Asenapine 22200:Ergolines 22197:Agonists: 22168:SB-204070 22163:SB-203186 22148:Piboserod 22138:GR-125487 22133:GR-113808 22117:Zacopride 22102:Tegaserod 22092:RS-67,506 22087:RS-67,333 22077:PRX-03140 22067:Mosapride 22052:Dazopride 22047:CJ-033466 22042:Cisapride 22032:Capeserod 22019:Agonists: 21959:Zacopride 21901:mianserin 21897:amoxapine 21858:Memantine 21828:Dazopride 21813:Bupropion 21798:Azasetron 21784:clozapine 21760:Alosetron 21726:halothane 21708:2-Me-5-HT 21699:SR-57227A 21678:quipazine 21635:Agonists: 21575:Ergolines 21570:Efavirenz 21509:Trazodone 21489:mianserin 21473:amoxapine 21454:SB-243213 21449:SB-242084 21444:SB-228357 21439:SB-221284 21434:SB-206553 21429:SB-200646 21419:RS-102221 21404:Pizotifen 21374:Ketotifen 21359:FR-260010 21311:Ergolines 21237:melperone 21225:clozapine 21217:asenapine 21138:bufotenin 21116:Ro60-0213 21111:Ro60-0175 21101:PNU-22394 21091:quipazine 21069:mescaline 21056:PHA-57378 21046:ORG-37684 21041:ORG-12962 20998:pergolide 20946:Ergolines 20919:Dimemebfe 20914:CP-809101 20909:Alstonine 20904:AL-38022A 20885:α-Me-5-HT 20881:5-MeO-αMT 20877:5-MeO-αET 20855:5-MeO-DPT 20851:5-MeO-DMT 20843:5-MeO-DET 20806:Agonists: 20772:Ergolines 20756:Yohimbine 20736:Trazodone 20726:mianserin 20722:amoxapine 20713:Tegaserod 20703:SB-228357 20698:SB-221284 20693:SB-215505 20688:SB-206553 20683:SB-204741 20678:SB-200646 20668:RS-127445 20653:PRX-08066 20643:Pizotifen 20618:LY-393558 20603:LY-272015 20583:Ergolines 20578:EGIS-7625 20539:clozapine 20527:asenapine 20465:bufotenin 20461:α-Me-5-HT 20435:Ro60-0175 20430:PNU-22394 20387:pergolide 20359:Ergolines 20332:BW-723C86 20289:Agonists: 20251:Ergolines 20235:Yohimbine 20207:spiramide 20203:spiperone 20143:mianserin 20127:amoxapine 20103:SR-46349B 20097:trazodone 20034:Pizotifen 19999:Nantenine 19969:LY-393558 19900:Ergolines 19824:melperone 19804:clozapine 19780:asenapine 19757:perlapine 19753:ketotifen 19671:bufotenin 19634:quipazine 19620:mescaline 19592:PNU-22394 19587:PHA-57378 19540:IHCH-7113 19529:pergolide 19465:Ergolines 19460:Efavirenz 19428:Dimemebfe 19418:AL-37350A 19399:α-Me-5-HT 19395:5-MeO-αMT 19391:5-MeO-αET 19369:5-MeO-DPT 19365:5-MeO-DMT 19357:5-MeO-DET 19303:25CN-NBOH 19291:25C-NBOMe 19287:25B-NBOMe 19283:25I-NBOMe 19267:Agonists: 19222:Mianserin 19168:LY-334370 19142:Ergolines 19132:BRL-54443 19129:Agonists: 19088:Ergolines 19026:Ergolines 19021:BRL-54443 19018:Agonists: 18988:pergolide 18976:Ergolines 18950:Yohimbine 18940:Mianserin 18930:LY-456220 18925:LY-456219 18920:LY-393558 18915:LY-367642 18910:LY-310762 18900:GR-127935 18890:Ergolines 18885:Elzasonan 18875:Alniditan 18722:Ergolines 18717:CP-286601 18712:CP-135807 18704:Agonists: 18662:Ergolines 18646:Yohimbine 18641:SB-236057 18636:SB-224289 18631:SB-216641 18621:LY-393558 18611:GR-127935 18601:Ergolines 18596:Elzasonan 18570:carteolol 18478:RU-24,969 18467:pergolide 18443:Ergolines 18433:CP-135807 18405:Agonists: 18371:Ergolines 18320:Spiramide 18315:Spiperone 18265:Lecozotan 18245:FCE-24379 18235:Ergolines 18220:BMY-7,378 18202:pindobind 18178:carteolol 18131:Yohimbine 18092:N-Me-5-HT 18080:bufotenin 18072:5-MeO-DMT 18044:Sarizotan 18024:RU-24,969 18019:Roxindole 18014:Repinotan 17979:Naluzotan 17964:LY-301317 17959:LY-293284 17898:pergolide 17862:Ergolines 17847:Ebalzotan 17837:Dimemebfe 17827:BMY-14802 17822:Befiradol 17795:buspirone 17773:clozapine 17761:asenapine 17735:trazodone 17704:8-OH-DPAT 17701:Agonists: 17395:Pentamine 17390:Pempidine 17340:Methadone 17335:Memantine 17255:Halothane 17245:Gallamine 17225:Enflurane 17180:Diadonium 17095:Bupropion 16880:SIB-1553A 16875:SIB-1508Y 16865:SB-206553 16690:Carbachol 16670:AR-R17779 16660:Anatabine 16655:Anabasine 16620:A-867,744 16615:A-582,941 16610:A-366,833 16482:See also: 16457:SoRI-9804 16405:Reserpine 16375:GBR-12935 16370:Efavirenz 16290:Roxindole 16268:methadone 16255:N-Me-5-HT 16225:Efavirenz 16183:3-MeO-PCP 16126:Amoxapine 15994:Pridefine 15964:Naphyrone 15828:Tofenacin 15747:Trazodone 15737:SB-649915 15732:Quipazine 15727:LY-393558 15652:Ifoxetine 15647:Indalpine 15523:methadone 15412:Mianserin 15402:Amoxapine 15270:Pridefine 15240:Naphyrone 15104:Tofenacin 15054:CP-39,332 14973:Fencamine 14968:Bupropion 14937:Tandamine 14932:Talsupram 14892:Daledalin 14790:Rimcazole 14780:Pridefine 14745:Modafinil 14670:Fluorenol 14640:Efavirenz 14573:Bupropion 14533:Adrafinil 14497:Tropoxane 14387:Altropane 14384:Tropanes: 14361:Naphyrone 14325:Pipradrol 14244:GBR-13098 14239:GBR-13069 14234:GBR-12935 14229:GBR-12783 14137:See also: 14116:Yohimbine 14111:Trazodone 14104:Rauvolfia 14036:Buspirone 14031:Bupropion 14010:vitamin E 14006:quebracho 13948:estradiol 13944:Estrogens 13926:Androgens 13898:Tadalafil 13873:Lodenafil 13807:Terguride 13782:Piribedil 13777:Pergolide 13695:Phase III 13683:Withdrawn 13629:Metformin 13614:Beloranib 13459:Exenatide 13384:Otenabant 13374:Drinabant 13330:Pipradrol 13255:Bupropion 13219:Yohimbine 13194:Ephedrine 13184:Albuterol 13131:Mefenorex 13081:Ephedrine 13046:Cathinone 12902:Lorazepam 12885:Clonidine 12855:Nalmefene 12817:Methadone 12806:+naloxone 12779:Clonidine 12739:Clonidine 12716:Nalmefene 12662:inhibitor 12639:Clonidine 12603:Bupropion 12533:Phase III 12521:Withdrawn 12386:Buspirone 12272:Minaprine 12207:Tedizolid 12202:Safrazine 12177:Octamoxin 12172:Nialamide 12162:Linezolid 12157:Isoniazid 12067:Mianserin 12009:Opipramol 11974:Iprindole 11954:Dosulepin 11919:Amoxapine 11875:Tricyclic 11733:Trazodone 11690:Mianserin 11662:Bupropion 11596:Tofenacin 11538:Indalpine 11487:Specific 11051:CiteSeerX 11049:: 21–46. 10515:19 August 10343:20 August 10317:18 August 10008:Chirality 9681:226292409 9550:257583439 9507:234883621 9423:253283525 9415:2772-4085 9367:1092-8529 9246:0272-4391 8726:19 August 8698:19 August 8693:BindingDB 8669:19 August 8659:Database" 8348:218563059 8186:215758102 7485:: 60–68. 7405:232141396 6943:CNS Drugs 6735:247057961 5993:Addiction 5721:233212535 5074:30 August 5049:30 August 4968:. USPTO. 4871:246238087 4821:27 August 4646:234472488 4575:229357583 4254:195687060 3870:9 January 3793:9 January 3763:9 January 3731:9 January 3665:9 January 3558:163167323 3460:Drugs.com 3225:Synthesis 3204:analogues 3176:of 239.74 3160:with the 3082:Chemistry 3056:half-life 3023:reductive 2994:oxidative 2932:(TAAR1). 2821:histamine 2817:serotonin 2801:receptors 2470:580–2,100 2300:443–3,240 2298:940–1,900 2251:550–2,170 2249:330–2,900 2247:372–2,780 2245:173–1,800 2115:14 (rat) 2085:67 (rat) 2082:inactive 2079:inactive 2076:inactive 2073:, uptake 2062:16 (rat) 2050:, uptake 2039:47 (rat) 2033:inactive 2027:, uptake 1956:bupropion 1944:bupropion 1932:bupropion 1920:bupropion 1852:nebivolol 1790:efavirenz 1774:ritonavir 1706:morbidity 1702:mortality 1670:psychosis 1654:placebo. 1604:Cases of 1391:psoriasis 1383:TNF-alpha 1333:trazodone 1096:pregnancy 1088:psychosis 1074:. Raised 1048:dry mouth 992:Bupropion 821:ChEMBL894 564:Excretion 515:half-life 469:, others) 272:Routes of 246:Pregnancy 235:Bupropion 194:Monograph 188:Drugs.com 170:3-Chloro- 160:3-Chloro- 129:-teh-moan 34:Bupropion 25:Buspirone 27491:Prodrugs 27395:Medicine 27367:Category 27117:NiQuitin 27107:Nicoderm 27102:Lucozade 27097:Horlicks 27079:Excedrin 27054:Caltrate 27000:Shingrix 26990:Rabavert 26985:Pediarix 26960:Infanrix 26940:FluLaval 26925:Cervarix 26920:Boostrix 26903:Vaccines 26878:Ventolin 26868:Serlipet 26858:Lamictal 26853:Hycamtin 26838:Beconase 26797:Products 26570:Phenibut 26256:Dopamine 26237:Ciladopa 26227:a-Me-TRA 26067:Eutylone 26057:Butylone 26001:Ethylone 25996:Butylone 25986:3,4-DMMC 25934:Eutylone 25884:4-MeMABP 25804:Pentorex 25794:Etolorex 25784:Cloforex 25561:Tiflorex 25453:Morforex 25378:Fludorex 25133:Beatrice 24926:Escaline 24442:Pimozide 24397:Dezocine 24287:Naloxone 24247:Metaphit 24242:Fourphit 24222:Unsorted 24158:Ibogaine 24098:SAS-0132 24048:UKH-1114 24005:Ketamine 23990:DKR-1051 23985:DKR-1005 23866:Ibogaine 23498:L-687384 23493:Ketamine 23145:lisuride 23119:pimozide 23115:loxapine 22954:LY-53857 22905:zotepine 22810:Triptans 22674:loxapine 22525:BVT-5182 22368:Hypidone 22346:lisuride 22158:RS-67532 22153:RS-39604 22143:L-Lysine 21980:LY-53857 21930:loxapine 21823:CSP-2503 21744:YM-31636 21694:SR-57227 21684:RS-56812 21638:Alcohols 21540:pimozide 21536:loxapine 21504:Tramadol 21323:LY-53857 21265:zotepine 21158:psilocin 20974:LA-SS-Az 20970:lisuride 20899:A-372159 20873:5-Fl-αMT 20869:5-Cl-αMT 20599:LY-53857 20595:lisuride 20485:psilocin 20310:cloforex 20297:Aminorex 20187:pimozide 20179:loxapine 20108:TGBA01AD 19908:LY-53857 19880:CSP-2503 19864:zotepine 19726:AC-90179 19691:psilocin 19501:LA-SS-Az 19497:lisuride 19413:AL-34662 19387:5-Fl-αMT 19383:5-Cl-αMT 19343:2C-B-FLY 19279:25I-NBOH 19275:25I-NBMD 19178:Triptans 19150:lysergol 19096:lysergol 19041:Triptans 18984:lysergol 18980:lisuride 18846:5-Et-DMT 18792:Triptans 18787:TGBA01AD 18762:L-772405 18757:L-694247 18752:GR-46611 18674:lisuride 18488:Triptans 18423:CP-94253 18418:CP-93129 18255:GR-46611 18225:CSP-2503 18206:pindolol 18116:Urapidil 18106:TGBA01AD 18096:psilocin 18029:S-14,506 17949:Hypidone 17929:F-15,599 17904:F-11,461 17882:lisuride 17842:Dopamine 17803:gepirone 17607:See also 17549:lecithin 17525:prodrugs 17475:Tramadol 17325:ME-18-MC 17290:Ketamine 17280:Ibogaine 17100:BW284C51 16855:RJR-2429 16845:Pyrantel 16805:Nicotine 16800:Morantel 16790:Lobeline 16755:EVP-6124 16750:EVP-4473 16705:Cytisine 16700:Cotinine 16605:A-84,543 16576:Agonists 16444:Luteolin 16395:Lobeline 16385:Ibogaine 16284:tramadol 16230:Hypidone 16191:ketamine 16169:loxapine 16029:Tropanes 15959:Mazindol 15949:JZ-IV-10 15783:CP-39332 15742:TGBA01AD 15535:tramadol 15478:ketamine 15464:loxapine 15305:Tropanes 15235:Mazindol 15225:JZ-IV-10 14927:Talopram 14912:Mazindol 14877:Amedalin 14735:Metaphit 14730:Mesocarb 14720:Mazindol 14690:Ketamine 14492:Troparil 14249:JJC8-088 14066:Oxytocin 13981:tibolone 13960:Premarin 13936:, other 13903:Udenafil 13863:Avanafil 13772:Lisuride 13654:ZGN-1061 13575:Orlistat 13422:and / or 13300:Mazindol 13240:Aminorex 13146:Pentorex 13111:Fludorex 13096:Etolorex 13061:Cloforex 12912:Oxazepam 12897:Diazepam 12790:Ibogaine 12750:Phenibut 12745:Baclofen 12613:Lobeline 12608:Cytisine 12459:GABAkine 12137:Benmoxin 12093:Tiazesim 11817:Ketamine 11802:Gepirone 11429:11091936 11353:21241211 11285:Archived 11233:28 April 11227:Archived 11205:24870292 11197:27504927 11162:23519045 11119:22468662 11081:Archived 11028:58587857 11020:30601027 10974:Archived 10943:Archived 10910:Archived 10876:Archived 10845:Archived 10710:Archived 10676:Archived 10672:Medscape 10641:23 March 10635:Archived 10606:19 April 10563:NBC News 10480:Archived 10443:Archived 10409:Archived 10337:Archived 10258:21191682 10168:43480769 10160:10999247 10117:4 August 10083:4 August 10054:4 August 9993:30601027 9920:31124380 9882:24484978 9798:15083067 9727:Archived 9723:16644475 9673:33186562 9635:23953570 9599:25670957 9542:36928557 9499:34218389 9464:25657796 9332:26791601 9297:27092049 9206:32746649 9168:18705749 9128:34736882 9074:26035635 9066:16005476 9031:19969097 8982:38287888 8931:15322260 8895:10379421 8634:27671323 8585:31871303 8528:15322260 8489:12909199 8454:19490821 8446:10379421 8406:20509659 8340:32386065 8305:30460996 8256:15554766 8221:18691982 8178:32285503 8129:14761997 8121:25655950 8080:27518170 8028:Archived 7963:16368442 7917:19031375 7843:31288917 7760:25097474 7711:26594724 7684:31595027 7635:25290793 7627:11888352 7592:24267809 7556:28605035 7507:19196303 7499:29715610 7456:Archived 7452:33102792 7444:25874915 7397:33682569 7353:Archived 7323:Archived 7294:32606041 7259:38465412 7224:16030444 7155:18253994 7106:28512664 7055:27167571 7014:16984660 6963:37792265 6927:27018393 6892:18497715 6835:Archived 6831:DailyMed 6805:Archived 6779:15809465 6727:35193485 6678:27916394 6637:29523488 6588:29649948 6539:15361919 6482:19440080 6447:21955201 6395:27813651 6360:30097390 6311:33085721 6271:PLOS ONE 6252:31570648 6203:32129504 6154:32343335 6113:33464342 6072:31684681 6023:29377409 5974:19195413 5966:16831112 5926:17156479 5875:37230961 5866:10207863 5823:18488428 5772:32512768 5713:33843549 5672:25267685 5664:18605812 5623:21 March 5590:27043678 5560:Medicine 5541:30883669 5492:18199864 5451:35045113 5419:PLOS Med 5400:35918097 5348:32101579 5308:PLOS ONE 5284:29477251 5219:Archived 5207:29677603 5148:35858125 5140:19185342 5092:(2023). 5069:ClinCalc 5043:Archived 5039:ClinCalc 5010:Archived 4970:Archived 4938:Archived 4896:Archived 4863:35068363 4815:Archived 4769:28965364 4709:24484978 4659:10 April 4650:Archived 4638:33977870 4579:Archived 4567:33354752 4525:28135844 4481:21872337 4441:24362450 4403:15705013 4327:22436728 4319:28850959 4284:16848671 4246:18370448 4206:27591914 4154:27141292 4022:27255113 3962:Archived 3927:Archived 3897:Archived 3893:DailyMed 3864:Archived 3860:DailyMed 3834:Archived 3830:DailyMed 3787:Archived 3757:Archived 3725:Archived 3699:3 August 3693:Archived 3659:Archived 3612:16027765 3550:31124380 3464:Archived 3430:See also 3418:Research 3330:seizures 3158:compound 3148:racemize 2949:cytokine 2882:receptor 2864:affinity 2813:dopamine 2657:α/β/δ/γ- 2230:Species 2204:no data 2201:no data 2198:no data 2179:no data 2176:no data 2148:no data 2145:no data 2118:no data 2088:no data 2065:no data 2042:no data 1970:relative 1760:such as 1758:inducers 1746:diazepam 1684:Overdose 1663:insomnia 1617:glaucoma 1530:epilepsy 1435:(POTS). 1362:orlistat 1115:dopamine 1092:overdose 1080:seizures 1060:insomnia 1033:by mouth 982:(verify) 704:DrugBank 360:Class C1 302:ATC code 261: B2 248:category 230:DailyMed 27087:Geritol 27083:Flonase 27059:Centrum 27049:Biotene 27031:Actifed 27005:Twinrix 26995:Rotarix 26955:Hiberix 26935:Fluarix 26915:Bexsero 26873:Tagamet 26833:Avandia 26804:Current 26671:Current 26610:UWA-101 26575:PRO-LAD 26505:ETH-LAD 26266:Epinine 26222:a-Me-DA 26145:4-MePPP 26140:4-MePHP 26135:4-MePBP 26047:Ariadne 25825:Others: 25735:3,4-DCA 25732:Others: 25683:2,3-MDA 25668:6-MAPDB 25633:5-MAPDB 25314:Cathine 25238:ZDCM-04 25223:Psi-DOM 25208:Ganesha 25074:Others: 24889:2C-T-33 24884:2C-T-32 24879:2C-T-31 24874:2C-T-30 24869:2C-T-28 24864:2C-T-27 24859:2C-T-25 24854:2C-T-24 24849:2C-T-23 24839:2C-T-22 24834:2C-T-21 24829:2C-T-20 24824:2C-T-19 24819:2C-T-18 24814:2C-T-17 24809:2C-T-16 24804:2C-T-15 24799:2C-T-14 24794:2C-T-13 24789:2C-T-12 24784:2C-T-11 24779:2C-T-10 24594:2C-B-AN 24312:UMB-116 24307:UMB-103 24302:UMB-101 24297:UMB-100 24088:MIN-101 24078:CT-1812 24068:BD-1067 24063:BD-1008 23970:BD-1047 23906:Saffron 23891:RHL-033 23661:Dup-734 23646:BD-1067 23641:BD-1063 23636:BD-1060 23631:BD-1047 23626:BD-1031 23621:BD-1008 23566:PRE-084 23383:Cocaine 23348:BD-1052 23157:(e.g., 23143:(e.g., 23097:(e.g., 23079:(e.g., 23057:(e.g., 23040:SLV-314 23035:SLV-313 22928:(e.g., 22916:DR-4485 22855:(e.g., 22822:(e.g., 22812:(e.g., 22772:(e.g., 22765:E-55888 22715:(e.g., 22693:(e.g., 22668:(e.g., 22656:doxepin 22646:(e.g., 22632:(e.g., 22515:AVN-397 22510:AVN-322 22505:AVN-211 22500:AVN-101 22464:(e.g., 22457:ABT-354 22426:ST-1936 22380:(e.g., 22332:(e.g., 22295:(e.g., 22281:(e.g., 22225:(e.g., 22202:(e.g., 21987:(e.g., 21938:(e.g., 21928:(e.g., 21911:Thujone 21895:(e.g., 21782:(e.g., 21775:AS-8112 21734:toluene 21724:(e.g., 21706:(e.g., 21668:(e.g., 21642:butanol 21640:(e.g., 21577:(e.g., 21530:(e.g., 21516:(e.g., 21499:TIK-301 21471:(e.g., 21424:S-14671 21313:(e.g., 21215:(e.g., 21177:WAY-629 21128:(e.g., 21077:(e.g., 21063:(e.g., 21016:(e.g., 20986:LSD-Pip 20948:(e.g., 20926:(e.g., 20867:(e.g., 20833:2C-T-21 20811:(e.g., 20774:(e.g., 20751:TIK-301 20743:(e.g., 20720:(e.g., 20585:(e.g., 20517:(e.g., 20447:(e.g., 20422:(e.g., 20400:(e.g., 20361:(e.g., 20339:(e.g., 20304:(e.g., 20253:(e.g., 20165:(e.g., 20155:(e.g., 20125:(e.g., 20071:(e.g., 20059:S-14671 19959:KML-010 19902:(e.g., 19770:(e.g., 19743:(e.g., 19661:(e.g., 19628:(e.g., 19614:(e.g., 19557:(e.g., 19513:LSD-Pip 19467:(e.g., 19440:(e.g., 19381:(e.g., 19348:2CB-Ind 19337:2C-T-21 19315:(e.g., 19271:25I-NBF 19198:(e.g., 19180:(e.g., 19144:(e.g., 19090:(e.g., 19053:(e.g., 19043:(e.g., 19028:(e.g., 18978:(e.g., 18892:(e.g., 18836:(e.g., 18794:(e.g., 18724:(e.g., 18664:(e.g., 18603:(e.g., 18564:(e.g., 18521:(e.g., 18490:(e.g., 18445:(e.g., 18373:(e.g., 18300:S-15535 18290:NAN-190 18237:(e.g., 18172:(e.g., 18149:(e.g., 18066:(e.g., 18039:S-15535 18034:S-14671 17974:MKC-242 17924:F-15063 17919:F-14679 17914:F-13714 17909:F-12826 17864:(e.g., 17793:(e.g., 17755:(e.g., 17721:(e.g., 17545:Choline 17105:BW-A444 17083:(e.g., 17076:BNC-210 17064:(e.g., 17027:ABT-126 17011:(e.g., 16970:XY-4083 16935:TC-6683 16930:TC-5619 16925:TC-5214 16920:TC-2216 16915:TC-1827 16910:TC-1734 16905:TC-1698 16815:NS-1738 16809:tobacco 16695:Choline 16640:ABT-894 16635:ABT-560 16630:ABT-418 16625:ABT-202 16380:GZ-793A 16324:(e.g., 16262:(e.g., 16260:Opioids 16181:(e.g., 16167:(e.g., 16133:(e.g., 16121:A-80426 16118:Others: 16080:Doxepin 16033:cocaine 16031:(e.g., 15979:NS-2359 15974:Nefopam 15929:HDMP-28 15919:EXP-561 15879:Cocaine 15808:McN5652 15687:RTI-353 15517:(e.g., 15515:Opioids 15476:(e.g., 15462:(e.g., 15440:(e.g., 15435:Others: 15356:Doxepin 15309:cocaine 15307:(e.g., 15255:NS-2359 15250:Nefopam 15205:HDMP-28 15195:EXP-561 15155:Cocaine 15079:McN5652 14998:LR-5182 14760:NS-2359 14750:Nefopam 14710:LR-5182 14655:EXP-561 14530:Others: 14482:RTI-336 14477:RTI-229 14472:RTI-177 14467:RTI-150 14462:RTI-126 14457:RTI-121 14452:RTI-113 14447:RTI-112 14407:Cocaine 14305:HDMP-28 14224:DBL-583 14121:Yohimbe 14089:cocaine 14083:(e.g., 13998:Afrodor 13968:(e.g., 13946:(e.g., 13928:(e.g., 13868:Icariin 13835:PL-6983 13434:AMG 133 13223:Yohimbe 13199:Ephedra 13086:Ephedra 13041:Cathine 12796:Opioids 12391:Lithium 11959:Doxepin 11491:and/or 11388:1918431 11291:9 April 11127:1310940 10808:. U.S. 10734:. U.S. 10629:. U.S. 10281:Bibcode 10249:3724447 10209:7768026 10049:PubChem 10028:8240925 9958:3107223 9825:1813908 9590:4310912 9455:4314873 9288:4820462 9271:: 148. 9119:8559442 9022:4135078 8860:9537821 8825:7855217 8790:3816971 8755:6086881 8721:PubChem 8687:Liu T. 8651:Roth BL 8625:5148637 8576:6978693 8536:1577336 8397:2895766 8296:6465131 7998:8830063 7908:3550116 7834:6637660 7780:. U.S. 7751:4112250 7675:7002596 7547:6490529 7146:7025781 7005:1599716 6883:2797110 6718:9886814 6628:5960024 6579:5900810 6490:1663570 6438:3229037 6351:6109107 6302:7577505 6279:Bibcode 6243:7067282 6194:7059898 6063:6816175 6014:5947828 5917:1764891 5900:: 300. 5814:2528204 5763:7345023 5581:4998539 5532:6422318 5442:8769343 5391:9344377 5339:7043778 5316:Bibcode 5275:5889788 5215:5011570 4902:29 July 4892:PubChem 4760:6485546 4197:5540329 4145:4837968 4013:4959100 3933:7 March 3603:1163271 3343:generic 3300:History 3128:racemic 3047:erythro 3019:CYP2C19 2928:of the 2926:agonist 2885:agonist 2790:prodrug 2784:erythro 2479:Rodent 1950:Erythro 1930:Hydroxy 1918:Hydroxy 1906: 1879:alcohol 1859:seizure 1659:anxiety 1598:Seizure 1400:, like 1253:craving 1183:placebo 1064:anxiety 1044:placebo 1038:Common 869:Formula 713:DB01156 659:PubChem 434:Unknown 401:Rx-only 398:WARNING 370:: 318:) 312: ( 310:N06AX12 232:: 208:a695033 119:-pee-on 27381:Portal 27150:People 27127:Ribena 27024:Former 26975:Menveo 26970:Kinrix 26945:Havrix 26910:Arexvy 26888:Zantac 26843:Boniva 26818:Advair 26811:Pharma 26713:Haleon 26708:Former 26693:Tesaro 26525:IP-LAD 26445:AL-LAD 26217:6-OHDA 25752:(also 25745:DiFMDA 25663:6-MAPB 25653:6-EAPB 25643:6-APDB 25628:5-MAPB 25618:5-EAPB 25613:5-APDB 25218:MMDA-2 25118:3C-MAL 25070:MDMPEA 24921:DESOXY 24899:2C-TFM 24894:2C-TFE 24774:2C-T-9 24769:2C-T-8 24764:2C-T-7 24759:2C-T-6 24754:2C-T-5 24749:2C-T-4 24744:2C-T-3 24739:2C-T-2 24714:2C-O-4 24704:2C-NH2 24679:2C-G-N 24674:2C-G-6 24669:2C-G-5 24664:2C-G-4 24659:2C-G-3 24654:2C-G-2 24649:2C-G-1 24327:YZ-185 24322:YZ-069 24317:YZ-011 24208:UMB-82 24203:UMB-23 24083:LR-172 24073:CM-156 24058:AC-927 23975:BD1063 23936:YKP10A 23901:RTI-55 23788:4-IPBS 23778:4C-T-2 23696:NE-100 23691:MS-377 23686:LR-172 23681:LR-132 23666:E-5842 23656:CM-156 23616:AC-927 23601:UMB-82 23596:UMB-23 23343:BD-737 23318:4-PPBP 22790:LP-211 22580:MS-245 22406:E-6837 22402:E-6801 21656:m-CPBG 21187:YM-348 21036:MK-212 20950:ALD-52 20829:2C-T-7 20825:2C-T-2 19654:TFMFly 19577:O-4310 19473:ALD-52 19469:1P-LSD 19433:DMBMPP 19333:2C-T-7 19329:2C-T-2 18330:UH-301 18270:Mefway 17135:Curare 17052:AQW051 16999:18-MAC 16955:UB-165 16765:GTS-21 16595:5-HIAA 16563:nAChRs 16434:Others 15989:PRC200 15934:HP-505 15677:PIM-35 15265:PRC200 15210:HP-505 15018:O-2172 14765:O-2172 14442:RTI-55 13991:Others 13678:WHO-EM 13607:Others 13529:5-HT2C 13506:DACRAs 12516:WHO-EM 12229:Mixed: 12086:Others 11770:Others 11678:NaSSAs 11427: 11386: 11351: 11314: 11259: 11223:Гарант 11203: 11195: 11160: 11125: 11117: 11053: 11026: 11018: 10746:3 July 10381:27 May 10256: 10246: 10207: 10166: 10158: 10108: 10026: 9991: 9956: 9918: 9880: 9870: 9823: 9796: 9758: 9721: 9679: 9671: 9633: 9597: 9587: 9548: 9540: 9505: 9497: 9462: 9452: 9421: 9413: 9365: 9330: 9295: 9285: 9244: 9204: 9166: 9126: 9116: 9072: 9064: 9029: 9019: 8980: 8929: 8893: 8858: 8823: 8788: 8753: 8632: 8622: 8583: 8573: 8534: 8526: 8487: 8452: 8444: 8404: 8394: 8346: 8338: 8303: 8293: 8254: 8219: 8184: 8176: 8127: 8119: 8078: 7996: 7961: 7915: 7905: 7864: 7841: 7831: 7792:13 May 7758: 7748: 7709: 7682: 7672: 7633: 7625: 7590: 7554: 7544: 7505: 7497: 7450: 7442: 7403: 7395: 7292: 7257: 7222: 7153: 7143: 7104: 7053: 7012: 7002: 6988:: 24. 6961: 6925: 6890: 6880: 6777: 6733: 6725: 6715: 6676: 6635: 6625: 6586: 6576: 6537: 6530:514842 6527: 6488: 6480: 6445: 6435: 6393: 6358: 6348: 6309: 6299: 6250: 6240: 6201: 6191: 6152: 6111: 6070: 6060: 6048:(10). 6021: 6011: 5972: 5964: 5924: 5914: 5873: 5863: 5821: 5811: 5770: 5760: 5719: 5711: 5670: 5662: 5588: 5578: 5539: 5529: 5490: 5449: 5439: 5398: 5388: 5346: 5336: 5282: 5272: 5254:Lancet 5213: 5205: 5146: 5138: 5120:Lancet 4976:2 June 4944:5 June 4930: 4869: 4861: 4809: 4799: 4767: 4757: 4707: 4697: 4644: 4636: 4585:17 May 4573: 4565: 4523: 4479: 4439: 4401: 4325: 4317: 4282: 4252: 4244: 4204: 4194: 4152: 4142: 4078: 4020: 4010: 3610: 3600: 3556: 3548: 3214:, and 3199:salt. 3178: 3035:AKR7A3 3031:AKR7A2 3010:- and 3002:CYP2B6 2914: 2848: 2836: 2823:, and 2781:, and 2737:, GABA 2717:, 5-HT 2711: 2703:Notes: 2697:Human 2673:Human 2651:Human 2625:Human 2595:Human 2586:12,000 2565:Human 2535:Human 2505:Human 2457:Human 2435:Human 2409:Human 2353:15,600 1850:, and 1801:CYP2D6 1788:, and 1780:, and 1752:, and 1726:CYP2B6 1518: 1516:mg/105 1514: 1506: 1502: 1490: 1486: 1481: 1477: 1473: 1458:tablet 1408:, and 1406:abulia 1402:apathy 1150: 1070:, and 1068:tremor 1052:nausea 1016:add-on 937:SMILES 904:239.74 812:ChEMBL 781:D00817 773:D07591 581: 577: 573: 556: 552: 546: 542: 536: 532: 526: 522: 507:Others 505: 497: 489: 481: 467:CYP2B6 395: 382: 372:℞-only 358: 345: 228: 132: 125:am-fa- 27324:Other 27228:Other 27035:Advil 26753:Glaxo 26700:(85%) 26560:MT-45 26313:-DOPS 26304:-DOPA 26245:-DOPA 26212:6-FNE 26155:MOPVP 26150:MOPPP 26125:MDPPP 26120:MDPBP 26115:α-PVP 26110:α-PPP 26105:α-PHP 26100:α-PBP 26042:4-MAB 26037:4-CAB 25991:3-MMC 25889:4-MPD 25879:4-MEC 25874:4-FMC 25869:4-EMC 25864:4-CMC 25859:4-BMC 25849:3-FMC 25821:MDMPH 25718:MMDMA 25698:MDHMA 25638:6-APB 25608:5-APB 25603:4-MTA 25598:4-MMA 25588:4-FMA 25260:3-FMA 25250:2-FMA 25203:DOTFM 25158:DMMDA 25153:DMCPA 25128:Aleph 25108:3C-BZ 25103:3C-AL 25082:DMPEA 25065:MDPEA 24976:TCB-2 24946:MEPEA 24904:2C-YN 24729:2C-SE 24724:2C-Ph 24694:2C-iP 24634:2C-EF 24619:2C-CP 24614:2C-CN 24604:2C-Bu 24599:2C-Bn 24292:SM-21 24033:PB-28 23960:3-PPP 23783:4-IBP 23611:3-PPP 23313:3-PPP 22785:LP-44 22780:LP-12 22755:AS-19 22027:BIMU8 21948:xenon 21095:TFMPP 20424:TFMPP 19649:TCB-2 19638:TFMPP 19602:RH-34 18514:TFMPP 18165:AV965 17984:NBUMP 17523:(and 17505:Xenon 17004:18-MC 16983:(and 16579:(and 16305:VMATs 14517:WF-33 14512:WF-31 14507:WF-23 14502:WF-11 13664:Water 13539:5-HTP 13414:GLP-1 13233:Other 12486:5-HTP 12050:TeCAs 11711:SARIs 11645:NDRIs 11564:SNRIs 11506:SSRIs 11201:S2CID 11123:S2CID 11024:S2CID 10913:(PDF) 10902:(PDF) 10780:(PDF) 10765:(PDF) 10716:5 May 10706:(FDA) 10702:U.S. 10682:9 May 10483:(PDF) 10476:(FDA) 10472:U.S. 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