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Anthony Cashmore

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and Director of the Plant Science Institute there until his retirement in 2011. Since 2011, he has been a Professor emeritus at the University of Pennsylvania (Department of Biology). Cashmore has authored more than 100 refereed research papers and has served on the editorial boards of the
717:, an element that is commonly missing is awareness that individuals are responsible for neither their genetic inheritance nor their environment. Based on this observation, he therefore asked "where does this notion of free will come from?" and challenged the 684:
screening. This research was the foundation that led to the identification of CRY proteins in other plant species, bacteria, fungi, animals, and humans, as well as research that defined the pivotal role of these proteins in
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mutant. Ahmad and Cashmore called this blue light photoreceptor "cryptochrome", and it is now referred to as CRY1. Cashmore's research group identified a second member of the cryptochrome family (CRY2) using
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Cashmore showed that in contrast to the RuBisCO large subunit (which was known to be synthesized on chloroplast ribosomes), the small subunit of RuBisCO was produced as a soluble
3006: 413: 260: 2649: 918: 3196: 1577:"The degradation of DNA by hydrazine: A critical study of the suitability of the reaction for the quantitative determination of purine nucleotide sequences" 1744: 1032: 3223: 1994:"In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii" 321:, and then as an assistant professor, then Associate Professor. In 1986, Cashmore was appointed the Director of the Plant Science Institute at the 1024: 1147: 2135:"Cell-free synthesis of leaf protein: Identification of an apparent precursor of the small subunit of ribulose-1,5-bisphosphate carboxylase" 1623:"The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues" 440:
conditions undergoes degradation, Cashmore defined a quantitative technique for measuring purine nucleotides in DNA samples. Subsequently,
3299: 2491: 1313: 227:, Cashmore led the Plant Science Institute from the time of his appointment in 1986 until his retirement in 2011. He was elected to the 2426:
Timko, M; Kausch, A; Castresana, C; Fassler, J; Herrera-Estrella, L; Van den Broeck, G; Van Montagu, M; Schell, J; Cashmore, A (1985).
2317:"Light-inducible and chloroplast-associated expression of a chimaeric gene introduced into Nicotiana tabacum using a Ti plasmid vector" 951: 1382: 3284: 3016: 835:
Timko MP, Kaush AP, Castresana C, Fassler J, Herrera-Estrella L, Van den Broeck G, Van Montagu M, Schell J, and Cashmore AR (1985)
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of conserved residues occurred supporting one of the early models proposed for the three dimensional structure of transfer RNA.
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genetics" for the study of light regulation, in 1980 Cashmore, working with post-doctoral student Margaret Ahmad, identified
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Amita Sehgal, ed. (April 2004). "Chapter 8: Physiological and molecular characteristics of plant circadian clocks".
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nuclear RuBisCO small subunit gene. For these studies, Cashmore collaborated with scientists in the laboratory of
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Herrera-Estrella L, Van den Broeck G, Maenhaut R, Van Montagu M, Schell J, Timko M, and Cashmore A (1984)
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Einwich, Angelika; Dedek, Karin; Seth, Pranav Kumar; Laubinger, Sascha; Mouritsen, Henrik (25 Sep 2020).
2603: 1783: 1576: 2711: 1143:"Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2" 705:
In recent years, Cashmore turned his attention to the topic of human behavior, studying the concepts of
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Lee, G-H; Moon, H; Kim, H; Lee, GH; Kwon, W; Yoo, S; Myung, D; Yun, SH; Bao, Z; Hahn, SK (2020).
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Herrera-Estrella, L; Van den Broeck, G; Van Montagu, M; Schell, J; Timko, M; Cashmore, A (1984).
922:, Herrera-Estrella, Luis; Van Den Broeck, Guido & Van Montagu, Marc et al., " 291: 287: 1103:
Biologic Effects of Light 1998: Proceedings of a Symposium Basel, Switzerland November 1–3, 1998
545:. At New Zealand's DSIR Palmerston North, Cashmore studied the biosynthesis of RuBisCO, a multi- 3274: 2206:"Synthesis and transport of the small subunit of chloroplast ribulose bisphosphate carboxylase" 1496:"The structure of prostratin : A toxic tetracyclic diterpene ester from Pimelea Prostrata" 620:, functioning in either orientation and when fused to a normally non-light-regulated promoter. 577: 314: 267: 212:. These specialized proteins are critical for plant development and play an essential role in 154: 56: 2938: 2860:"The Lucretian swerve: The biological basis of human behavior and the criminal justice system" 1784:"Selective reaction of methoxyamine with cytosine bases in tyrosine transfer ribonucleic acid" 1472: 1211:"HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor" 3073: 3039: 2972: 1274: 931: 645: 581: 392: 209: 89: 2712:"Scientific Background Discoveries of Molecular Mechanisms Controlling the Circadian Rhythm" 895:
The Lucretian swerve: The biological basis of human behavior and the criminal justice system
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photonic healthcare devices, are based on the function of the cryptochrome photoreceptors.
461: 347: 279: 69: 2650:"Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1" 816:
Light-inducible and chloroplast-associated expression of a chimaeric gene introduced into
568:. The soluble precursor protein is subsequently processed and imported into chloroplasts. 8: 1500: 878:
Association of flavin adenine dinucleotide with the Arabidopsis blue light receptor CRY1.
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regulation across species and as the primary sensory molecule enabling light-dependent
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system. The article stimulated discussion and analysis by scientists in the fields of
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fragment. In a second study, this DNA fragment was shown to have the properties of an
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Lin C, Robertson D, Ahmad M, Raibekas A, Jorns M, Dutton P, and Cashmore A. (1995)
863: 839: 822: 752: 690: 597: 495: 256: 2291: 1918: 3224:"Geoscientist William Bonini, dedicated teacher and genial colleague, dies at 90" 3163: 2081: 1832: 1101: 686: 609: 585: 546: 542: 377: 369: 213: 2428:"Light regulation of plant gene expression by an upstream enhancer-like element" 971:
Chapter 8: Physiological and molecular characteristics of plant circadian clocks
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
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Light regulation of plant gene expression by an upstream enhancer-like element.
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Proceedings of the National Academy of Sciences of the United States of America
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and the criminal justice system, he was β€˜instantly converted to determinism’.
3263: 2496: 1318: 946:, Cashmore, Anthony Robert; Ahmad, Margaret & Lin, Chentao, " 710: 131: 2878: 2673: 2648:
Lin, C; Robertson, D; Raibekas, A; Jorns, M; Dutton, P; Cashmore, A (1995).
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factor(s) responsible for this effect. Interested in adopting the "power of
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Chimaeric gene coding for a transit peptide and a heterologous polypeptide
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
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plant cells, they demonstrated that in the pea plant, light-regulated
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encodes a protein with characteristics of a blue-light photoreceptor.
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New Zealand's Department of Scientific and Industrial Research (DSIR)
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New Zealand's Department of Scientific and Industrial Research (DSIR)
217: 73: 298:. In 1971 Cashmore moved to the United States, where he worked as a 1141:
Lin, C; Yang, H; Guo, H; Mockler, T; Chen, J; Cashmore, AR (1998).
993:), to parents Nancy and Norman Cashmore. He is married to American 986: 927: 739: 565: 488: 472: 351: 330: 252: 248: 240: 149: 1740:"Memoirs: Daniel McGillivray Brown. 3 February 1923β€”24 April 2012" 1272: 693:
in migratory birds. Today, light-based diagnostic and therapeutic
436:. Recognizing that hydrazine-treated DNA subsequently exposed to 756: 514: 549:(eight large and eight small subunits) protein located in plant 3151:
http://www.nasonline.org/member-directory/members/20002156.html
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to blue light. Elusive to discovery, scientists gave the name
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Exploring the Illusion of Free Will and Moral Responsibility
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Members of the United States National Academy of Sciences
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Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO)
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University of Pennsylvania Department of Biology faculty
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Hall, Jeffrey; Rosbach, Michael; Young, Michael (2017).
1879:"Detailed molecular model for transfer ribonucleic acid" 333:
Professor of Biology at the University of Pennsylvania.
2492:"Science: Darwin's plants give up their 'blue' secrets" 1314:"Science: Darwin's plants give up their 'blue' secrets" 948:
Blue light photoreceptors and methods of using the same
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employed the hydrazine degradation approach to develop
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Garry C. Whitelam; Karen J. Halliday (15 April 2008).
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that showed reduced sensitivity to blue light. Using
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and how selective chemical reagents could be used to
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Biographical Memoirs of Fellows of the Royal Society
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Michael F. Holick; Ernst G. Jung (6 December 2012).
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American Association for the Advancement of Science
2970: 2257: 1992:Dobberstein, B; Blobel, G; Cjua, NH (1 Mar 1977). 1782: 1780: 1493: 1276:Annual Plant Reviews, Light and Plant Development 1140: 3261: 3100:"About the PNAS Member Editor: Anthony Cashmore" 2709: 1620: 1574: 1536:"On the structure of prostratin: An X-ray study" 942: 487:to identify the reactive cytosine residues in a 2936: 3037: 2203: 1534:McCormick, IRN; Nixon, PE; Waters, TN (1976). 1348:Penn Arts & Sciences Department of Biology 952:The Trustees of the University of Pennsylvania 950:", published 1998-10-20, assigned to 926:", published 1998-03-17, assigned to 671:the gene and discovered that the mutants were 483:procedure that had recently been developed by 2964: 2793: 2133:Cashmore, A; Broadhurst, K; Gray, RE (1978). 1941:"The global mass and average rate of rubisco" 1473:"Plant Biology Tree: Anthony Robert Cashmore" 1208: 3161: 3041:Free: Why Science Hasn't Disproved Free Will 2383:Biography of Pioneers in Plant Biotechnology 1669: 1570: 1568: 424:. Cashmore and Petersen examined the use of 2578: 2310: 2308: 1781:Cashmore, AR; Brown, DB; Smith, JD (1971). 969:Jarillo J, Capel J, and Cashmore AR (2004) 783:Cashmore was a Professor of Biology at the 701:Human behavior, free will and consciousness 234: 3155: 3074:"Free will is an illusion, biologist says" 2258:Lubben, TH; Theg, SM; Keegstra, K (1988). 1938: 771:stated that after reading this article on 743:", equivalent to the continuing belief in 509: 422:determine the nucleic acid sequence of DNA 329:). He retired in 2011 and is currently an 294:Department of Chemistry, and later at the 282:degree in 1966. In 1968 Cashmore moved to 29: 3044:. Oxford University Press. pp. 53–. 2887: 2877: 2827: 2770: 2402: 2370: 2260:"Transport of proteins into chloroplasts" 2197: 2173: 2163: 2102: 2029: 2019: 1968: 1958: 1757: 1714: 1704: 1646: 1565: 1527: 1448: 1438: 1178: 1168: 1106:. Springer Science & Business Media. 464:, Cashmore demonstrated that the reagent 398: 313:In 1979, Cashmore took a position at the 270:, majoring in chemistry and completing a 3168:. John Wiley & Sons. pp. 185–. 3031: 2857: 2376: 2305: 2079: 1830: 1494:CASHMORE AR, SEELYE RN, CAIN BF (1976). 1408: 1406: 1404: 1389:. University of Pennsylvania. 5 May 2003 803: 721:to reconsider the concept of free will. 403: 2601: 2595: 2204:Highfield, PE; Ellis, RJ (2 Feb 1978). 1939:Bar-On, Yinon; Milo, Ron (5 Mar 2019). 1279:. John Wiley & Sons. pp. 17–. 1266: 1136: 1134: 1132: 1130: 1068:"Curriculum Vitae, ANTHONY R. CASHMORE" 3262: 3215: 3165:Molecular Biology of Circadian Rhythms 3004: 2998: 2930: 2853: 2851: 2849: 2847: 2584: 2517: 2511: 2489: 2251: 1876: 1870: 1377: 1375: 1373: 1371: 1369: 1367: 1365: 1311: 1307: 1305: 1303: 975:Molecular Biology of Circadian Rhythms 788:publications Plant Molecular Biology, 3221: 3189: 2904: 2703: 2419: 2073: 1932: 1774: 1731: 1487: 1401: 1338: 1336: 1204: 1202: 1200: 1198: 1093: 1019: 1017: 636:demonstrated that plants exhibited a 372:the active component, referred to as 3256:Google Scholar - Anthony R. Cashmore 3140:. National Academy of Sciences. 2021 3132:"Member Directory: Anthony Cashmore" 3124: 3092: 3071: 3065: 2971:Lubomira Radoilska (19 April 2012). 2787: 2730: 2641: 2591:. New York: D. Appleton and Company. 2126: 1985: 1737: 1465: 1412: 1127: 1062: 1060: 1058: 1056: 1054: 778: 255:. As a teenager, Cashmore worked in 223:in the Department of Biology at the 3038:Alfred R. Mele (2 September 2014). 2844: 2483: 2055:"Will Rubisco stop global warming?" 1621:Cashmore, AC; Petersen, GB (1978). 1614: 1575:Cashmore, AR; Petersen, GB (1969). 1362: 1300: 808: 732:approach, Cashmore argued that all 296:MRC Laboratory of Molecular Biology 13: 3300:University of Pennsylvania faculty 2943:. Lexington Books. pp. 186–. 2620:10.1111/j.1751-1097.1979.tb07209.x 2490:Miller, Susan Katz (20 Nov 1993). 2046: 1824: 1663: 1333: 1312:Miller, Susan Katz (20 Nov 1993). 1195: 1014: 612:was mediated by a 1 kilobase (kb) 572:Light-regulated enhancer sequences 308:University of California, Berkeley 14: 3321: 3249: 2052: 1679:"A new method for sequencing DNA" 1051: 310:before returning to New Zealand. 3285:New Zealand molecular biologists 1475:. The Academic Family Tree. 2021 1415:"Profile of Anthony R. Cashmore" 980: 963: 584:associated with light regulated 2937:Gregg D. Caruso (5 July 2013). 2608:Photochemistry and Photobiology 2588:The Power of Movement in Plants 2090:Journal of Biological Chemistry 1738:Gait, Michael J. (7 Nov 2018). 1209:Ahmad, M; Cashmore, AR (1993). 852:Ahmad M and Cashmore AR (1993) 667:techniques, Cashmore and Ahmed 623: 555:inhibitors of protein synthesis 350:studies, Cashmore purified the 247:) in 1941, Cashmore grew up in 16:New Zealand molecular biologist 3295:Rockefeller University faculty 3015:. Chicago, USA. Archived from 1413:Nair, Prashant (11 Jan 2011). 502:. This finding suggested that 412:(a New Zealand biochemist) at 259:in the Grasslands Division of 1: 3290:University of Auckland alumni 2104:10.1016/S0021-9258(17)33567-6 1552:10.1016/S0040-4039(00)92939-3 1514:10.1016/S0040-4039(00)92940-X 1035:. 23 Dec 1998. Archived from 1007: 341: 205:, best known for identifying 3222:Kelly, Morgan (3 Jan 2017). 3137:National Academy of Sciences 3110:National Academy of Sciences 3105:National Academy of Sciences 2977:. OUP Oxford. pp. 33–. 2974:Autonomy and Mental Disorder 1803:10.1016/0022-2836(71)90056-8 1790:Journal of Molecular Biology 1593:10.1016/0005-2787(69)90289-5 798:National Academy of Sciences 728:to probe the concept from a 691:magnetic compass orientation 537:of interest in the field of 229:National Academy of Sciences 115:National Academy of Sciences 7: 2604:"Blue Light Photoreception" 675:of a previously identified 479:. Later, Cashmore used the 10: 3326: 2916:informationphilosopher.com 2763:10.1038/s41598-020-72579-2 2520:"New light on stem growth" 1344:"Retired/Emeritus Faculty" 1079:University of Pennsylvania 912: 820:using a Ti plasmid vector. 785:University of Pennsylvania 525:through the conversion of 460:Working with Dan Brown at 432:nucleotides in samples of 323:University of Pennsylvania 225:University of Pennsylvania 146:University of Pennsylvania 2820:10.1038/s41578-019-0167-3 730:Philosophy of Information 527:ribulose-1,5-bisphosphate 471:with a limited number of 336: 266:Cashmore enrolled at the 216:of plants and animals. A 168: 164: 141: 127: 120: 109: 99: 80: 52: 37: 28: 21: 2800:Nature Reviews Materials 2585:Darwin, Charles (1881). 2518:Briggs, Winslow (1993). 932:Plant Genetic Systems NV 796:. He was elected to the 450:Maxam–Gilbert sequencing 368:, Cashmore purified and 366:partition chromatography 235:Early life and education 3280:New Zealand biochemists 2879:10.1073/pnas.0915161107 2674:10.1126/science.7638620 2377:Estrella, Luis (2020). 2264:Photosynthesis Research 1960:10.1073/pnas.1816654116 1440:10.1073/pnas.1018069108 767:. Scientist and author 510:Biosynthesis of RuBisCO 455: 292:University of Cambridge 2718:. Nobel Prize Outreach 2021:10.1073/pnas.74.3.1082 1849:10.1038/newbio230236a0 1759:10.1098/rsbm.2018.0008 1627:Nucleic Acids Research 1170:10.1073/pnas.95.5.2686 578:Rockefeller University 399:Nucleic acid chemistry 360:, a New Zealand toxic 315:Rockefeller University 268:University of Auckland 210:photoreceptor proteins 197:(b. 22 Jan 1941) is a 155:Rockefeller University 113:Elected Member of the 57:University of Auckland 2858:Cashmore, AR (2010). 2165:10.1073/pnas.75.2.655 2080:Cashmore, AR (1976). 1706:10.1073/pnas.74.2.560 985:Cashmore was born in 901:107 (10), 4499–4504. 804:Selected publications 543:fixing carbon dioxide 519:photosynthetic energy 428:as a tool to measure 404:Hydrazine degradation 393:x-ray crystallography 302:in the laboratory of 159:(Associate Professor) 3233:. Princeton, NJ, USA 3229:Princeton University 3005:Harris, Lee (2018). 1831:Cashmore, T (1971). 1639:10.1093/nar/5.7.2485 719:scientific community 638:phototropic response 529:to two molecules of 462:Cambridge University 278:degree in 1963, and 150:(Professor Emeritus) 3072:Zyga, Lisa (2010). 3019:on 16 November 2018 2812:2020NatRM...5..149L 2755:2020NatSR..1015794E 2666:1995Sci...269..968L 2602:Gressel, J (1979). 2541:1993Natur.366..110B 2446:1985Natur.318..579T 2333:1984Natur.310..115H 2222:1978Natur.271..420H 2156:1978PNAS...75..655C 2012:1977PNAS...74.1082D 1895:1969Natur.224..759L 1697:1977PNAS...74..560M 1540:Tetrahedron Letters 1501:Tetrahedron Letters 1431:2011PNAS..108..443N 1387:penntoday.upenn.edu 1229:1993Natur.366..162A 1161:1998PNAS...95.2686L 893:Cashmore, A (2010) 761:behavioral sciences 580:, Cashmore studied 541:due to its role in 272:Bachelor of Science 203:molecular biologist 195:Anthony R. Cashmore 23:Anthony R. Cashmore 3012:The Chicago Maroon 2912:"Anthony Cashmore" 2743:Scientific Reports 2276:10.1007/BF00047688 2059:www.economarks.com 1877:Levitt, M (1969). 1837:Nature New Biology 734:biological systems 553:. Using selective 531:3-phosphoglycerate 523:fix carbon dioxide 389:chemical synthesis 304:Michael Chamberlin 300:Research Associate 3175:978-0-471-41824-5 3051:978-0-19-937164-8 2984:978-0-19-959542-6 2950:978-0-7391-7732-7 2872:(10): 4499–4504. 2660:(5226): 968–970. 2535:(6451): 110–111. 2440:(6046): 579–582. 2395:10.1111/pbi.13319 2327:(5973): 115–120. 2216:(5644): 420–424. 1953:(10): 4738–4743. 1889:(5221): 759–763. 1546:(20): 1735–1736. 1508:(20): 1737–1738. 1286:978-0-470-99429-0 1223:(6451): 162–166. 1113:978-1-4615-5051-8 818:Nicotiana tabacum 790:The Plant Journal 779:Honors and awards 745:Cartesian duality 726:scientific method 715:nature vs nurture 618:enhancer sequence 604:(Belgium). Using 559:precursor protein 357:Pimelea prostrata 276:Master of Science 214:circadian rhythms 192: 191: 186:/anthony-cashmore 136:Molecular biology 122:Scientific career 88:, the blue light 3317: 3243: 3242: 3240: 3238: 3219: 3213: 3212: 3210: 3208: 3203:. 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658: 655: 651: 647: 646:photoreceptor 643: 639: 635: 631: 621: 619: 615: 611: 607: 603: 599: 595: 591: 587: 583: 582:DNA sequences 579: 569: 567: 564: 560: 556: 552: 548: 544: 540: 536: 532: 528: 524: 520: 516: 507: 505: 501: 497: 493: 490: 486: 482: 478: 474: 470: 467: 463: 453: 451: 447: 443: 439: 435: 431: 427: 423: 419: 418:nucleic acids 415: 411: 408:Working with 396: 394: 390: 386: 382: 379: 375: 371: 367: 363: 359: 358: 354:component of 353: 349: 334: 332: 328: 324: 320: 316: 311: 309: 305: 301: 297: 293: 289: 285: 281: 277: 273: 269: 264: 262: 258: 254: 250: 246: 242: 232: 230: 226: 222: 219: 215: 211: 208: 204: 200: 196: 187: 171: 167: 163: 156: 151: 147: 144: 140: 137: 133: 132:Plant biology 130: 126: 123: 119: 116: 112: 108: 105: 102: 98: 95: 91: 90:photoreceptor 87: 84:Discovery of 83: 79: 75: 71: 67: 63: 58: 55: 51: 40: 36: 32: 27: 20: 3253: 3235:. 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Bob Doyle 991:New Zealand 859:A. thaliana 773:determinism 769:Jerry Coyne 654:Arabidopsis 650:Arabidopsis 594:Jeff Schell 563:cytoplasmic 533:. It is an 485:Fred Sanger 442:Allan Maxam 346:During his 245:New Zealand 94:Arabidopsis 3264:Categories 2990:28 January 2956:28 January 1752:: 79–100. 1675:Gilbert, W 1119:23 January 1008:References 999:Geneticist 944:US 5824859 920:US 5728925 792:, and the 765:philosophy 610:expression 606:transgenic 586:expression 492:suppressor 385:croton oil 374:prostratin 342:Prostratin 286:to pursue 201:and plant 199:biochemist 1671:Maxam, AM 1075:upenn.edu 930: and 800:in 2003. 707:free will 628:In 1881, 566:ribosomes 426:hydrazine 231:in 2003. 218:Professor 176:.pantheon 74:Chemistry 3078:phys.org 2898:20142481 2838:32728478 2781:32978454 2690:40649563 2628:98643540 2565:42260720 2413:31883186 2284:24429668 2184:16592495 1979:30782794 1768:81639128 1677:(1977). 1459:21191100 987:Auckland 928:Bayer AG 907:20142481 857:gene of 740:vitalism 695:wearable 614:promoter 500:loop III 494:tRNA of 489:tyrosine 473:cytosine 364:. 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Index


University of Auckland
BS
MS
PhD
Chemistry
cryptochrome
photoreceptor
Arabidopsis
Nancy Bonini
National Academy of Sciences
Plant biology
Molecular biology
University of Pennsylvania
(Professor Emeritus)
Rockefeller University
live-sas-bio.pantheon.sas.upenn.edu/people/anthony-cashmore
biochemist
molecular biologist
cryptochrome
photoreceptor proteins
circadian rhythms
Professor
emeritus
University of Pennsylvania
National Academy of Sciences
Auckland
New Zealand
Manawaru
Te Aroha

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