547:
524:
38:
29:
860:
Acebutolol is well absorbed from the GI tract, but undergoes substantial first-pass-metabolization, leading to a bioavailability of only 35% to 50%. Peak plasma levels of acebutolol are reached within 2 to 2.5 hours after oral dosing. Peak levels of the main active metabolite, diacetolol, are reached
868:
Acebutolol undergoes extensive hepatic metabolization resulting in the desbutyl amine acetolol which is readily converted into diacetolol. Diacetolol is as active as acebutolol (equipotency) and appears to have the same pharmacologic profile. Geriatric patients tend to have higher peak plasma levels
812:
Acebutolol is a cardioselective beta-1 blocker which also considered a partial agonist due to its intrinsic sympathomimetic activity (ISA). This means it provides low-grade beta stimulation at rest but acting as typical beta-blockers when sympathetic activity is high. Among other drugs in the
800:) have been seen. Altogether, 5 to 6% of all patients treated have to discontinue acebutolol due to intolerable side effects. When possible, the treatment should be discontinued gradually in order to avoid a withdrawal syndrome with increased frequency of angina and even precipitation of
869:
of both acebutolol and diacetolol and a slightly prolonged excretion. Excretion is substantially prolonged in patients with renal impairment, and so a dose reduction may be needed. Liver cirrhosis does not seem to alter the pharmacokinetic profile of the parent drug and metabolite.
821:(COPD) who needs treatment with a beta-blocker. This cardio-specificity will minimize the anti-hypertensive effects as seen with non-specific beta blockers such as Propanalol and Nadolol. (For these reasons, it may be a beta-blocker of choice in inclusion in
851:
plasma concentrations, although acebutolol may be more efficient in patients with high or normal renin plasma concentrations. In clinically relevant concentrations, a membrane-stabilizing effect does not appear to play an important role.
813:
beta-blocker class, Acebutolol will provide beta-blockade effects to a lesser extent. Due to its cardioselectivity, Acebutolol is more suitable than non-cardioselective beta-blockers, in a patient with
111:
784:-like syndrome with skin rash and multiforme organ involvement is even less frequent. The incidence of both ANA and symptomatic disease under acebutolol is higher than under
825:
strategies). In doses lower than 800 mg daily its constricting effects on the bronchial system and smooth muscle vessels are only 10% to 30% of those observed under
1291:
780:(ANA) has been found in 10 to 30% of patients under treatment with acebutolol. A systemic disease with arthralgic pain and myalgias has been observed in 1%. A
163:
1368:
616:
2233:
2213:
60:
1284:
640:
714:. Acebutolol is a cardioselective beta-1 blocker and has intrinsic sympathetic activity. It is commonly used in the treatment of angina.
3646:
2941:
2268:
1521:
668:
InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
3599:
1277:
985:
829:
treatment, but there is experimental evidence that the cardioselective properties diminish at doses of 800 mg/day or more.
788:. Female patients are more likely to develop these symptoms than male patients. Some few cases of hepatotoxicity with increased
3581:
3572:
3563:
1235:
897:
818:
3590:
844:
decrease has been observed. In this regard, it is unlike many other beta-blockers which have this unfavourable property.
685:
924:
660:
107:
1252:
293:
193:
92:
3608:
372:
2599:
3554:
542:
423:
2433:
1983:
1723:
1311:
1199:
978:
503:
1888:
1177:
1095:
744:
492:
3641:
1906:
1007:
841:
519:
2554:
1240:
837:
777:
148:
50:
70:
3631:
2319:
2011:
2001:
1572:
1329:
971:
914:
2518:
2294:
1937:
801:
738:
472:
363:
887:
3177:
797:
793:
432:
327:
252:
412:
8:
2856:
2722:
2198:
2104:
1501:
1407:
1300:
781:
318:
840:. Acebutolol has no negative impact on serum lipids (cholesterol and triglycerides). No
546:
523:
1303:
732:
122:
3636:
3287:
3262:
3182:
2060:
1810:
1675:
920:
893:
208:
84:
889:
The
Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
3257:
2821:
2664:
2463:
2041:
1803:
1793:
1354:
559:
222:
176:
2055:
1363:
1269:
352:
240:
230:
3167:
2836:
2801:
2522:
2278:
2188:
1941:
1806:
1526:
1481:
1246:
760:
3625:
3317:
3157:
2841:
2785:
2742:
2403:
2327:
2193:
2132:
2021:
1910:
1822:
1576:
1496:
1491:
1435:
1422:
789:
756:
627:
535:
37:
3342:
3327:
3272:
2767:
2589:
2534:
2526:
2498:
2458:
2377:
2343:
2158:
1953:
1945:
1926:
1914:
1798:
1667:
1643:
1603:
1065:
998:
994:
726:
707:
703:
171:
20:
3467:
3442:
3437:
3432:
3322:
3297:
3282:
3267:
3232:
3217:
3197:
3192:
3162:
3142:
3117:
3102:
3047:
2992:
2921:
2916:
2911:
2871:
2866:
2772:
2757:
2727:
2717:
2702:
2673:
2644:
2488:
2478:
2453:
2443:
2408:
2351:
2314:
2243:
2238:
2218:
2183:
2119:
2094:
2084:
2065:
2026:
1896:
1773:
1768:
1728:
1703:
1693:
1683:
1653:
1648:
1623:
1598:
1592:
1557:
1516:
1511:
1476:
1461:
1456:
1402:
1392:
1373:
1334:
1070:
826:
785:
711:
156:
78:
392:
3532:
3522:
3512:
3497:
3492:
3477:
3457:
3452:
3427:
3422:
3407:
3387:
3382:
3377:
3347:
3337:
3332:
3302:
3292:
3252:
3242:
3222:
3172:
3152:
3132:
3127:
3107:
3092:
3087:
3077:
3057:
3052:
3042:
3037:
3032:
3012:
2997:
2987:
2946:
2931:
2906:
2901:
2896:
2881:
2876:
2861:
2846:
2831:
2826:
2816:
2806:
2762:
2747:
2737:
2712:
2707:
2688:
2678:
2659:
2654:
2634:
2629:
2619:
2614:
2604:
2594:
2584:
2574:
2569:
2513:
2503:
2493:
2483:
2423:
2413:
2393:
2388:
2373:
2347:
2339:
2335:
2309:
2304:
2253:
2248:
2228:
2223:
2178:
2168:
2163:
2153:
2114:
2099:
2089:
2050:
2036:
1932:
1922:
1883:
1878:
1868:
1863:
1853:
1838:
1814:
1788:
1778:
1763:
1758:
1748:
1743:
1713:
1698:
1671:
1633:
1619:
1615:
1611:
1588:
1584:
1547:
1506:
1486:
1466:
1451:
1417:
1397:
1349:
1344:
1216:
1211:
1189:
1152:
1132:
1127:
1122:
1080:
1056:
1051:
1041:
1036:
1026:
1021:
1016:
833:
592:
403:
28:
963:
3527:
3517:
3502:
3482:
3472:
3447:
3417:
3397:
3392:
3372:
3367:
3362:
3312:
3307:
3277:
3247:
3237:
3202:
3187:
3147:
3137:
3122:
3112:
3097:
3072:
3067:
3062:
3027:
3022:
3002:
2972:
2936:
2891:
2886:
2851:
2811:
2752:
2732:
2693:
2639:
2624:
2609:
2579:
2540:
2508:
2473:
2468:
2438:
2383:
2365:
2361:
2331:
2323:
2263:
2203:
2173:
2148:
2109:
2075:
2031:
1969:
1900:
1892:
1873:
1858:
1848:
1843:
1828:
1818:
1783:
1753:
1738:
1733:
1718:
1708:
1687:
1658:
1638:
1627:
1580:
1567:
1562:
1552:
1542:
1471:
1412:
1383:
1339:
1221:
1167:
1162:
1157:
1147:
1117:
1031:
862:
338:
267:
64:
3412:
3402:
3352:
3227:
3212:
3207:
3017:
2982:
2977:
2951:
2926:
2793:
2683:
2649:
2530:
2428:
2418:
2398:
2369:
2355:
2299:
2273:
2258:
2140:
2070:
1959:
1949:
1833:
1679:
1663:
1607:
1443:
1378:
1137:
1112:
1061:
822:
452:
383:
847:
The drug works in hypertensive patients with high, normal, or low
615:
3507:
3487:
3462:
3357:
3082:
3007:
2448:
2016:
1964:
1918:
1142:
1085:
1075:
1046:
764:
2777:
2124:
2006:
1427:
814:
483:
272:
865:
of 3 to 4 hours, and diacetolol a half-life of 8 to 13 hours.
717:
It was patented in 1967 and approved for medical use in 1973.
848:
606:
463:
245:
958:
942:
Beta blockers in the management of chronic coronary syndrome
508:
2208:
443:
277:
371:
1299:
3623:
351:
912:
326:
106:
1285:
979:
885:
939:
214:In general: â„ž (Prescription only)
1292:
1278:
986:
972:
545:
522:
411:
36:
27:
431:
648:O=C(Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C)CCC
993:
518:
391:
83:
3624:
919:. John Wiley & Sons. p. 461.
536:
202:
1273:
967:
836:properties and therefore crosses the
819:chronic obstructive pulmonary disease
491:
471:
101:
69:
940:Kannam JP, Gersh BJ (9 April 2019).
750:
175:
855:
451:
342:
13:
14:
3658:
3647:N-isopropyl-phenoxypropanolamines
952:
133:
861:after 4 hours. Acebutolol has a
576:
570:
3600:Monoamine metabolism modulators
913:Fischer J, Ganellin CR (2006).
807:
771:
720:
673:Key:GOEMGAFJFRBGGG-UHFFFAOYSA-N
933:
906:
879:
582:
564:
309:-{3-acetyl-4-phenyl}butanamide
262:8-13 hours (active metabolite)
1:
3582:Monoamine reuptake inhibitors
3555:Receptor/signaling modulators
916:Analogue-based Drug Discovery
872:
698:, sold under the brand names
886:Elks J, Ganellin CR (1990).
7:
2665:Deoxyepinephrine (epinine,
2042:Deoxyepinephrine (epinine,
1889:Tetracyclic antidepressants
1355:Deoxyepinephrine (epinine,
10:
3663:
3591:Monoamine releasing agents
554:Chemical and physical data
3545:
2960:
2562:
2553:
2287:
1994:
1982:
1907:Tricyclic antidepressants
1535:
1322:
1310:
1230:
1198:
1176:
1094:
1006:
892:. Springer. pp. 2–.
681:
656:
636:
632:121 °C (250 °F)
626:
604:
591:
558:
553:
534:
502:
482:
462:
442:
422:
402:
382:
362:
337:
317:
289:
284:
266:
251:
239:
229:
221:
192:
187:
162:
147:
121:
91:
77:
59:
49:
44:
35:
26:
944:. Waltham, MA: UpToDate.
2320:Atypical antipsychotics
1573:Atypical antipsychotics
778:anti-nuclear antibodies
731:Ventricular and atrial
260:3-4 hours (parent drug)
2519:Typical antipsychotics
2002:(R)-3-Nitrobiphenyline
1938:Typical antipsychotics
745:Smith–Magenis syndrome
55:Sectral, Prent, others
3609:Monoamine neurotoxins
802:myocardial infarction
741:in high-risk patients
739:myocardial infarction
706:for the treatment of
235:40% (range 35 to 50%)
3178:Dichloroisoprenaline
763:(due to its partial
2857:Phenylpropanolamine
2723:Ethylnorepinephrine
2199:Phenylpropanolamine
2105:Ethylnorepinephrine
1502:Phenylpropanolamine
1408:Ethylnorepinephrine
1301:Adrenergic receptor
838:blood–brain barrier
782:lupus erythematosus
776:The development of
702:among others, is a
211:(Prescription only)
23:
1257:Never to phase III
733:cardiac arrhythmia
19:
3619:
3618:
3612:
3603:
3594:
3585:
3576:
3567:
3558:
3541:
3540:
3288:Iodocyanopindolol
3263:Hydroxytertatolol
3183:Dihydroalprenolol
2796:
2788:
2780:
2697:
2549:
2548:
2143:
2135:
2127:
2079:
2061:Dihydroergotamine
1978:
1977:
1811:hydroxynefazodone
1676:dihydroergotamine
1446:
1438:
1430:
1387:
1267:
1266:
899:978-1-4757-2085-3
751:Contraindications
693:
692:
617:Interactive image
504:CompTox Dashboard
206:
137:
104:
16:Chemical compound
3654:
3642:Aromatic ketones
3606:
3597:
3588:
3579:
3570:
3561:
3549:
3258:Hydroxycarteolol
2822:Methoxyphenamine
2794:
2786:
2781:-DOPA (levodopa)
2778:
2695:
2669:-methyldopamine)
2560:
2559:
2464:Phenoxybenzamine
2141:
2133:
2128:-DOPA (levodopa)
2125:
2077:
2046:-methyldopamine)
1992:
1991:
1804:Phenylpiperazine
1794:Phenoxybenzamine
1444:
1436:
1431:-DOPA (levodopa)
1428:
1385:
1369:Dexisometheptene
1359:-methyldopamine)
1320:
1319:
1294:
1287:
1280:
1271:
1270:
988:
981:
974:
965:
964:
946:
945:
937:
931:
930:
910:
904:
903:
883:
856:Pharmacokinetics
767:or ISA activity)
689:
688:
619:
599:
584:
578:
572:
566:
549:
538:
527:
526:
512:
510:
495:
475:
455:
435:
415:
395:
375:
355:
345:
344:
330:
256:
204:
201:
179:
135:
132:
114:
103:
100:
87:
73:
40:
31:
24:
22:
18:
3662:
3661:
3657:
3656:
3655:
3653:
3652:
3651:
3622:
3621:
3620:
3615:
3537:
2956:
2545:
2283:
2056:Dexmedetomidine
1987:
1974:
1807:antidepressants
1531:
1364:Desglymidodrine
1315:
1306:
1298:
1268:
1263:
1262:
1247:Clinical trials
1226:
1205:- + β-selective
1203:
1194:
1181:
1172:
1099:
1090:
1010:, non-selective
1002:
992:
955:
950:
949:
938:
934:
927:
911:
907:
900:
884:
880:
875:
858:
810:
774:
761:unstable angina
753:
723:
684:
682:
677:
674:
669:
664:
663:
652:
649:
644:
643:
622:
597:
587:
581:
575:
569:
530:
506:
498:
478:
458:
438:
418:
398:
378:
358:
341:
333:
313:
310:
297:
296:
276:
261:
254:
231:Bioavailability
223:Pharmacokinetic
217:
183:
150:
143:
124:
117:
17:
12:
11:
5:
3660:
3650:
3649:
3644:
3639:
3634:
3617:
3616:
3614:
3613:
3604:
3595:
3586:
3577:
3568:
3559:
3546:
3543:
3542:
3539:
3538:
3536:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3168:Dexpropranolol
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2964:
2962:
2958:
2957:
2955:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2869:
2864:
2859:
2854:
2849:
2844:
2839:
2837:Norepinephrine
2834:
2829:
2824:
2819:
2814:
2809:
2804:
2802:Levosalbutamol
2799:
2791:
2789:-Phenylalanine
2783:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2691:
2686:
2681:
2676:
2671:
2662:
2657:
2652:
2647:
2642:
2637:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2566:
2564:
2557:
2551:
2550:
2547:
2546:
2544:
2543:
2538:
2523:chlorpromazine
2516:
2511:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2359:
2317:
2312:
2307:
2302:
2297:
2291:
2289:
2285:
2284:
2282:
2281:
2279:Xylometazoline
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2206:
2201:
2196:
2191:
2189:Norepinephrine
2186:
2181:
2176:
2171:
2166:
2161:
2156:
2151:
2146:
2138:
2136:-Phenylalanine
2130:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2087:
2082:
2073:
2068:
2063:
2058:
2053:
2048:
2039:
2034:
2029:
2024:
2019:
2014:
2009:
2004:
1998:
1996:
1989:
1985:
1980:
1979:
1976:
1975:
1973:
1972:
1967:
1962:
1957:
1942:chlorpromazine
1935:
1930:
1904:
1886:
1881:
1876:
1871:
1866:
1861:
1856:
1851:
1846:
1841:
1836:
1831:
1826:
1801:
1796:
1791:
1786:
1781:
1776:
1771:
1766:
1761:
1756:
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790:liver enzymes
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58:
54:
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48:
45:Clinical data
43:
39:
34:
30:
25:
3607:
3598:
3589:
3580:
3571:
3562:
3551:
3550:
3343:Metipranolol
3328:Levomoprolol
3273:Idropranolol
2967:
2768:Isoprenaline
2666:
2590:Arformoterol
2535:thioridazine
2527:fluphenazine
2499:Spiroxatrine
2459:Phentolamine
2378:tandospirone
2344:paliperidone
2234:Tasipimidine
2214:Rezatomidine
2159:Medetomidine
2043:
1954:thioridazine
1946:fluphenazine
1927:trimipramine
1915:clomipramine
1799:Phentolamine
1668:acetergamine
1644:Corynanthine
1356:
1107:
1066:Iodopindolol
941:
935:
915:
908:
888:
881:
867:
859:
846:
831:
811:
808:Pharmacology
775:
772:Side effects
727:Hypertension
721:Medical uses
716:
708:hypertension
704:beta blocker
699:
695:
694:
683:
306:
302:
253:Elimination
194:Legal status
188:Legal status
93:License data
3468:Spirendolol
3443:Propranolol
3438:Propafenone
3433:Pronethalol
3323:Levobunolol
3298:Isoxaprolol
3283:Indopanolol
3268:ICI-118,551
3233:Eugenodilol
3218:Ersentilide
3198:Draquinolol
3193:Diprafenone
3163:Dalbraminol
3143:Cicloprolol
3118:Carpindolol
3103:Butofilolol
3048:Bornaprolol
2993:Alprenoxime
2961:Antagonists
2922:Tulobuterol
2917:Tretoquinol
2912:Terbutaline
2872:Ractopamine
2867:Prenalterol
2773:Isoxsuprine
2758:Indacaterol
2728:Eugenodilol
2718:Etilevodopa
2703:Epinephrine
2694:Droxidopa (
2674:Dipivefrine
2645:Clenbuterol
2489:Setiptiline
2479:Rauwolscine
2454:Pardoprunox
2444:Mirtazapine
2409:Fenmetozole
2352:risperidone
2315:Atipamezole
2288:Antagonists
2244:Tiamenidine
2239:Tetryzoline
2219:Rilmenidine
2184:Naphazoline
2120:Guanoxabenz
2095:Epinephrine
2085:Etilevodopa
2076:Droxidopa (
2066:Dipivefrine
2027:Brimonidine
1897:maprotiline
1774:Pardoprunox
1769:Niguldipine
1729:Mepiprazole
1704:Hydroxyzine
1694:Etoperidone
1684:nicergoline
1654:Domesticine
1649:Dapiprazole
1624:eugenodilol
1599:Benoxathian
1593:risperidone
1558:Anisodamine
1536:Antagonists
1517:Tiamenidine
1512:Tetryzoline
1477:Naphazoline
1462:Methoxamine
1457:Metaraminol
1403:Etilevodopa
1393:Epinephrine
1384:Droxidopa (
1374:Dipivefrine
1335:Amidephrine
1243:from market
1071:Propranolol
827:propranolol
786:propranolol
712:arrhythmias
600: g·mol
543:100.048.654
285:Identifiers
79:MedlinePlus
51:Trade names
3626:Categories
3533:Xipranolol
3523:Toliprolol
3513:Tiprenolol
3498:Tienoxolol
3493:Tertatolol
3478:Sulfinalol
3458:Soquinolol
3453:Ronactolol
3428:Procinolol
3423:Primidolol
3408:Penbutolol
3388:Pacrinolol
3383:Oxprenolol
3378:Nipradilol
3348:Metoprolol
3338:Mepindolol
3333:Medroxalol
3303:Isamoltane
3293:Iprocrolol
3253:Flusoxolol
3243:Falintolol
3223:Esatenolol
3173:Diacetolol
3153:Cloranolol
3133:Celiprolol
3128:Carvedilol
3108:Capsinolol
3093:Butaxamine
3088:Bupranolol
3078:Bunitrolol
3058:Bucindolol
3053:Brefonalol
3043:Bopindolol
3038:Bisoprolol
3033:Bevantolol
3013:Arotinolol
2998:Amosulalol
2988:Alprenolol
2968:Acebutolol
2947:Zilpaterol
2932:Vilanterol
2907:Solabegron
2902:Salmeterol
2897:Salbutamol
2882:Reproterol
2877:Procaterol
2862:Pirbuterol
2847:Oxyfedrine
2832:Mirabegron
2827:Methyldopa
2817:Melevodopa
2807:Lubabegron
2763:Isoetarine
2748:Higenamine
2738:Formoterol
2713:Etilefrine
2708:Etafedrine
2689:Dopexamine
2679:Dobutamine
2660:Denopamine
2655:Corbadrine
2635:Carmoterol
2630:Carbuterol
2620:Broxaterol
2615:Bitolterol
2605:Bambuterol
2595:Arotinolol
2585:Arbutamine
2575:Alifedrine
2570:Abediterol
2514:Tolazoline
2504:Sunepitron
2494:Spegatrine
2484:Rotigotine
2424:Ketanserin
2414:Fluparoxan
2394:Cirazoline
2389:Buflomedil
2374:ipsapirone
2362:Azapirones
2348:quetiapine
2340:olanzapine
2336:lurasidone
2310:Aptazapine
2305:Amesergide
2254:Tolonidine
2249:Tizanidine
2229:Talipexole
2224:Romifidine
2179:Moxonidine
2169:Methyldopa
2164:Melevodopa
2154:Lofexidine
2115:Guanfacine
2100:Etilefrine
2090:Ergotamine
2051:Detomidine
2037:Corbadrine
1933:Trimazosin
1923:imipramine
1884:Tolazoline
1879:Tiodazosin
1869:Tamsulosin
1864:Talipexole
1854:Spegatrine
1839:Quinazosin
1815:nefazodone
1789:Phendioxan
1779:Pelanserin
1764:Niaprazine
1759:Neldazosin
1749:Naftopidil
1744:Moxisylyte
1714:Ketanserin
1699:Fenspiride
1672:ergotamine
1634:Buflomedil
1620:carvedilol
1616:arotinolol
1612:amosulalol
1589:quetiapine
1585:olanzapine
1548:Ajmalicine
1507:Synephrine
1487:Octopamine
1467:Methyldopa
1452:Melevodopa
1418:Indanidine
1398:Etilefrine
1350:Corbadrine
1345:Cirazoline
1304:modulators
1217:Carvedilol
1212:Arotinolol
1190:Butaxamine
1183:-selective
1153:Metoprolol
1133:Celiprolol
1128:Bisoprolol
1123:Bevantolol
1108:Acebutolol
1101:-selective
1081:Tertatolol
1057:Penbutolol
1052:Oxprenolol
1042:Mepindolol
1037:Cloranolol
1027:Bupranolol
1022:Bopindolol
1017:Alprenolol
873:References
834:lipophilic
696:Acebutolol
605:3D model (
593:Molar mass
473:CHEBI:2379
433:67P356D8GH
404:ChemSpider
364:IUPHAR/BPS
328:37517-30-9
319:CAS Number
294:IUPAC name
241:Metabolism
155:By mouth,
112:Acebutolol
21:Acebutolol
3552:See also:
3528:Xibenolol
3518:Tolamolol
3503:Tilisolol
3483:Talinolol
3473:SR 59230A
3448:Ridazolol
3418:Practolol
3398:Pamatolol
3393:Pafenolol
3373:Nifenalol
3368:Nebivolol
3363:Nadoxolol
3313:Landiolol
3308:Labetalol
3278:Indenolol
3248:Flestolol
3238:Exaprolol
3203:Ecastolol
3188:Dilevalol
3148:Cinamolol
3138:Cetamolol
3123:Carteolol
3113:Carazolol
3098:Butidrine
3073:Bufuralol
3068:Bufetolol
3063:Bucumolol
3028:Betaxolol
3023:Befunolol
3003:Ancarolol
2973:Adaprolol
2937:Xamoterol
2892:Ritodrine
2887:Rimiterol
2852:PF-610355
2812:Mabuterol
2797:-Tyrosine
2753:Ibopamine
2733:Fenoterol
2640:Cimaterol
2625:Buphenine
2610:Befunolol
2580:Amibegron
2541:Yohimbine
2509:Terguride
2474:Piribedil
2469:Piperoxan
2439:Mianserin
2384:BRL-44408
2366:buspirone
2332:clozapine
2324:asenapine
2264:Vatinoxan
2204:Piperoxan
2174:Mivazerol
2149:Ibopamine
2144:-Tyrosine
2110:Guanabenz
2032:Clonidine
1970:Zolertine
1901:mianserin
1893:amoxapine
1874:Terazosin
1859:Spiperone
1849:Silodosin
1844:Quinidine
1829:Piperoxan
1819:trazodone
1784:Perlapine
1754:Nantenine
1739:Monatepil
1734:Metazosin
1719:L-765,314
1709:Indoramin
1688:terguride
1664:Ergolines
1659:Doxazosin
1639:Bunazosin
1628:labetalol
1581:clozapine
1568:Atiprosin
1563:Anisodine
1553:Alfuzosin
1543:Abanoquil
1472:Midodrine
1447:-Tyrosine
1413:Ibopamine
1340:Buspirone
1253:Phase III
1241:Withdrawn
1222:Labetalol
1168:Talinolol
1163:Practolol
1158:Nebivolol
1148:Landiolol
1118:Betaxolol
1032:Carteolol
863:half-life
493:ChEMBL642
268:Excretion
255:half-life
149:Routes of
123:Pregnancy
71:Monograph
65:Drugs.com
3637:Anilides
3413:Pindolol
3403:Pargolol
3353:Moprolol
3228:Esprolol
3213:Ericolol
3208:Epanolol
3018:Atenolol
2983:Afurolol
2978:Adimolol
2952:Zinterol
2927:Vibegron
2684:Dopamine
2650:Colterol
2563:Agonists
2531:loxapine
2429:Lisuride
2419:Idazoxan
2399:Efaroxan
2370:gepirone
2356:zotepine
2300:Adimolol
2274:Xylazine
2259:Urapidil
2071:Dopamine
1995:Agonists
1960:Urapidil
1950:loxapine
1834:Prazosin
1680:lisuride
1608:adimolol
1379:Dopamine
1323:Agonists
1138:Epanolol
1113:Atenolol
1062:Pindolol
823:Polypill
686:(verify)
384:DrugBank
164:ATC code
125:category
3508:Timolol
3488:Tazolol
3463:Sotalol
3358:Nadolol
3083:Bunolol
3008:Arnolol
2942:XP21279
2521:(e.g.,
2449:NAN-190
2364:(e.g.,
2322:(e.g.,
2269:XP21279
2017:Amitraz
1965:WB-4101
1940:(e.g.,
1919:doxepin
1909:(e.g.,
1891:(e.g.,
1809:(e.g.,
1666:(e.g.,
1606:(e.g.,
1575:(e.g.,
1522:XP21279
1143:Esmolol
1086:Timolol
1076:Sotalol
1047:Nadolol
765:agonist
700:Sectral
598:336.432
560:Formula
393:DB01193
339:PubChem
278:Biliary
246:Hepatic
180:)
174: (
172:C07AB04
138: C
110::
85:a687003
2698:-DOPS)
2080:-DOPS)
2007:4-NEMD
1388:-DOPS)
1236:WHO-EM
923:
896:
815:asthma
757:Stable
737:Acute
641:SMILES
484:ChEMBL
453:D02338
207:
105:
2012:6-FNE
1330:6-FNE
849:renin
661:InChI
607:JSmol
464:ChEBI
280:: 60%
275:: 30%
273:Renal
2600:BAAM
2434:mCPP
2295:1-PP
2209:PS75
1724:mCPP
921:ISBN
894:ISBN
710:and
444:KEGG
424:UNII
413:1901
373:7107
353:1978
225:data
61:AHFS
999:C07
842:HDL
817:or
798:AST
794:ALT
759:or
509:EPA
343:CID
209:POM
177:WHO
108:FDA
3628::
2533:,
2529:,
2525:,
2376:,
2372:,
2368:,
2354:,
2350:,
2346:,
2342:,
2338:,
2334:,
2330:,
2326:,
1952:,
1948:,
1944:,
1925:,
1921:,
1917:,
1913:,
1899:,
1895:,
1821:,
1817:,
1813:,
1686:,
1682:,
1678:,
1674:,
1670:,
1626:,
1622:,
1618:,
1614:,
1610:,
1591:,
1587:,
1583:,
1579:,
1249::
804:.
796:,
574:28
568:18
305:)-
303:RS
203:UK
157:IV
134:AU
102:US
2795:L
2787:L
2779:L
2696:L
2667:N
2555:β
2537:)
2380:)
2358:)
2142:L
2134:L
2126:L
2078:L
2044:N
1986:2
1984:α
1956:)
1929:)
1903:)
1825:)
1690:)
1630:)
1595:)
1445:L
1437:L
1429:L
1386:L
1357:N
1314:1
1312:α
1293:e
1286:t
1279:v
1202:1
1200:α
1180:2
1178:β
1098:1
1096:β
1064:/
1008:β
1001:)
997:(
987:e
980:t
973:v
929:.
902:.
792:(
609:)
586:4
583:O
580:2
577:N
571:H
565:C
511:)
507:(
307:N
301:(
205::
136::
63:/
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