39:
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reactivation in PEL cell cultures via stimulation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. The pathway involves the activation of the early-immediate viral protein RTA that contributes to the activation of the lytic cycle.
799:"A Comparison of Reactive Oxygen Species Generation by Rat Peritoneal Macrophages and Mast Cells Using the Highly Sensitive Real-Time Chemiluminescent Probe Pholasin: Inhibition of Antigen-Induced Mast Cell Degranulation by Macrophage-Derived Hydrogen Peroxide"
990:
Schaar, Dale; Goodell, Lauri; Aisner, Joseph; Cui, Xiao Xing; Han, Zheng Tao; Chang, Richard; Martin, John; Grospe, Stephanie; Dudek, Liesel; Riley, Joan; Manago, Jacqueline; Lin, Yong; Rubin, Eric H.; Conney, Allan; Strair, Roger K. (June 2006).
379:
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
389:
InChI=1/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
610:
testing. Cells must be divided in a cytogenic test to view the chromosomes. TPA is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as
945:
Cohen, Adina; Brodie, Chaya; Sarid, Ronit (April 2006). "An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus".
924:
17:
495:
742:
621:
to stimulate T-cell activation, proliferation, and cytokine production, and is used in protocols for intracellular staining of these cytokines.
490:
405:
625:
707:
Blumberg (1988). "Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture".
257:
993:"A phase I clinical trial of 12- O-tetradecanoylphorbol-13-acetate for patients with relapsed/refractory malignancies"
559:(PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms,
370:
853:"Megakaryocytic Differentiation of K562 Cells Induced by PMA Reduced the Activity of Respiratory Chain Complex IV"
502:
670:
663:"Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters"
611:
313:
234:
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196:
1049:
806:
709:
959:
1053:
351:
88:)-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9a
38:
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571:
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1112:
954:
992:
914:. 3rd ed. Barch, Margaret J., Knutsen, Turid., Spurbeck, Jack L., eds. 1997. Lippincott-Raven.
1102:
866:
751:
322:
216:
125:
51:
8:
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in mouse macrophages. Thus, TPA/PMA has been routinely used as an inducer for endogenous
550:
115:
870:
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355:
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was identified as the major reactive oxygen species induced by TPA/PMA but not by
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1016:
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CCCCCCCCCCCCCC(=O)O2C(C)1(O)C4/C=C(/C)C(=O)4(O)CC(\CO)=C/132(OC(C)=O)C3(C)C
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plant, a shrub found in
Southeast Asia, exposure to which provokes a
618:
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CCCCCCCCCCCCCC(=O)O1(2((C=C(C3(2C=C(C3=O)C)O)CO)41(C4(C)C)OC(=O)C)O)C
472:
Except where otherwise noted, data are given for materials in their
857:
277:
602:
TPA has a specific use in cancer diagnostics as a B-cell specific
155:
148:
603:
542:
289:
597:
553:
187:
167:
138:
92:-cyclopropabenzoazulene-9,9a-diyl 9a-acetate 9-tetradecanoate
339:
738:"Phorbol Diester Receptor Copurifies with Protein Kinase C"
268:
989:
549:
often employed in biomedical research to activate the
256:
1089:
944:
301:
743:Proceedings of the National Academy of Sciences
124:
925:"Flow Cytometry Intracellular Staining Guide"
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1052:at the U.S. National Library of Medicine
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888:
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819:
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617:TPA is also commonly used together with
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14:
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912:The AGT cytogenetics laboratory manual
735:
228:
850:
382:Key: PHEDXBVPIONUQT-RGYGYFBISA-N
195:
175:
997:Cancer Chemotherapy and Pharmacology
101:TPA, PMA, Phorbol myristate acetate,
18:12-O-tetradecanoylphorbol-13-acetate
640:-like rash. It underwent a phase 1
392:Key: PHEDXBVPIONUQT-RGYGYFBIBK
292:
276:
24:
25:
1134:
1043:
32:-Tetradecanoylphorbol-13-acetate
519:-Tetradecanoylphorbol-13-acetate
480:
445:
37:
947:The Journal of General Virology
671:Journal of Biological Chemistry
589:TPA is also being studied as a
535:phorbol 12-myristate 13-acetate
476:(at 25 °C , 100 kPa).
983:
938:
905:
844:
790:
729:
700:
654:
451:
439:
13:
1:
685:10.1016/S0021-9258(18)34459-4
647:
531:tetradecanoyl phorbol acetate
103:Tetradecanoylphorbol acetate.
1050:Tetradecanoylphorbol+Acetate
880:10.1371/journal.pone.0096246
821:10.4049/jimmunol.169.10.5866
612:chronic lymphocytic leukemia
527:tetradecanoylphorbol acetate
7:
632:TPA was first found in the
10:
1139:
525:), also commonly known as
466:616.83 g/mol
1075:"Phase 1 Clinical Trials"
1009:10.1007/s00280-005-0125-1
807:The Journal of Immunology
470:
426:
401:
366:
108:
98:
50:
45:
36:
1054:Medical Subject Headings
1061:"NCI Dictionary Entry"
969:10.1099/vir.0.81619-0
765:10.1073/pnas.80.1.36
593:in the treatment of
52:Preferred IUPAC name
871:2014PLoSO...996246H
756:1983PNAS...80...36N
551:signal transduction
33:
927:. eBioscience, Inc
541:) is a diester of
503:Infobox references
27:
953:(Pt 4): 795–802.
814:(10): 5866–5873.
678:(13): 7847–7851.
661:Castagna (1982).
545:. It is a potent
511:Chemical compound
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335:CompTox Dashboard
157:Interactive image
150:Interactive image
16:(Redirected from
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1044:External links
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1003:(6): 789–795.
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750:(1): 36–40.
747:
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624:TPA induces
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586:production.
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197:ChEMBL279115
109:Identifiers
99:Other names
89:
85:
81:
77:
73:
69:
65:
61:
57:
29:
1103:Carcinogens
608:cytogenetic
595:hematologic
563:. TPA is a
427:Properties
235:100.109.485
177:CHEBI:37537
1098:Diterpenes
1092:Categories
1080:2005-07-02
1066:2005-07-02
931:2011-09-25
717:(1): 1–8.
648:References
638:poison ivy
584:superoxide
576:superoxide
462:Molar mass
323:NI40JAQ945
248:IUPHAR/BPS
208:ChemSpider
137:3D model (
126:16561-29-8
116:CAS Number
1017:1432-0843
955:CiteSeerX
619:ionomycin
580:ionomycin
574:biology,
1033:33377618
1025:16231182
977:16528027
899:24817082
858:PLoS ONE
838:21433304
830:12421969
890:4015910
867:Bibcode
784:6296873
752:Bibcode
723:3275491
694:7085651
604:mitogen
543:phorbol
496:what is
494: (
290:PubChem
1056:(MeSH)
1031:
1023:
1015:
975:
957:
897:
887:
836:
828:
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775:393304
772:
721:
692:
634:Croton
598:cancer
567:drug.
554:enzyme
533:, and
491:verify
488:
406:SMILES
278:C05151
188:ChEMBL
46:Names
1029:S2CID
834:S2CID
802:(PDF)
666:(PDF)
371:InChI
303:27924
217:25977
168:ChEBI
139:JSmol
1021:PMID
1013:ISSN
973:PMID
895:PMID
826:PMID
780:PMID
719:PMID
690:PMID
626:KSHV
591:drug
314:UNII
269:KEGG
258:2341
1005:doi
965:doi
885:PMC
875:doi
816:doi
812:169
770:PMC
760:doi
680:doi
676:257
606:in
572:ROS
570:In
539:PMA
523:TPA
515:12-
340:EPA
293:CID
84:,9a
72:,7b
68:,7a
64:,4a
60:,1b
56:(1a
28:12-
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863:9
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682::
537:(
521:(
517:O
486:N
455:8
452:O
446:H
440:C
342:)
338:(
141:)
90:H
86:S
82:R
78:R
74:S
70:S
66:R
62:S
58:R
30:O
20:)
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