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Career Award (the award went to Dr. Svilen Bobev) 2007 Investigator in the
Pathogenesis of Infectious Disease, Burroughs Wellcome Fund 2007 Anderson Endowed Bridge Fellowship Award, Yale University 2006 Anderson Endowed Fellowship Award, Yale University 2000-2004 Human Frontier Science Program Organization Long-Term Postdoctoral Fellowship 1999-2000 European Molecular Biology Organization Long-Term Fellowship 1999 Roche Foundation Postdoctoral Fellowship (declined) 1999 Swiss National Science Foundation Fellowship (declined) 1995-1999 Predoctoral Fellowship, European Molecular Biology Laboratory (4 years) 1995 Bateman Scholarship- First Class Honors Degree, Trinity Hall, University of Cambridge, U.K. 1995 Kareen Thorne Prize- Top First Class Honors Degree in Biological Sciences, Trinity Hall, University of Cambridge, U.K. 1995 First Class Honours (top grade) Bachelor of Arts degree in biochemistry, University of Cambridge, U.K. 1992 Top grade (7) in all six subjects of the International Baccalaureate at the International School of Geneva, Switzerland
233:. He studies cellular mechanisms of viral gene sensing and silencing. His group employs a diverse set of complementary biophysical approaches including cryo-electron microscopy (cryoEM), X-ray crystallography, solution biophysics, fluorescence microscopy and cell biological approaches to understand the cellular mechanisms of viral gene sensing and silencing in molecular-level detail.
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Chang-Min Lee, Chuan Hua He, Adel M Nour, Yang Zhou, Bing Ma, Jin Wook Park, Kyung Hee Kim, Charles Dela Cruz, Lokesh Kumar Sharma, Mahmoud L Nasr, Yorgo Modis, Chun Geun Lee & Jack A Elias (2016). IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signaling and effector responses. Nat. Commun.,
639:"Български: Портрет на Теодорос Модис, гръцки търговец от Битоля, организатор на гръцката пропаганда в Македония, убит от дейци на ВМОРОEnglish: Theodoros Modis (Θεοδώρος Μόδης) a Greek Macedonian merchant and scholar of Monastir (Μοναστήρι Π. Γ. Δ. Μ) (Modern Bitola, Битола) Macedonia. Died: 1904"
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2019 Senior
Research Fellowship from the Wellcome Trust 2014 Senior Research Fellowship from the Wellcome Trust 2009 CINE Golden Eagle Award for the animation “Dengue Virus Visualization” on Teachers’ Domain 2008 Nominated for the 2009 American Crystallography Association Margaret C. Etter Early
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Christopher Sng, Sorcha O’Byrne, Daniil M. Prigozhin, Matthias R Bauer, Jenny C. Harvey, Michelle Ruhle, Ben G. Challis, Sara Lear, Lee
Roberts, Sarita Workman, Tobias Janowitz, L. Magiera, Rainer Doffinger, Matthew S. Buckland, Duncan J. Jodrell, Robert K. Semple, Timothy J. Wilson, Yorgo Modis
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Vinod Nayak, Moshe Dessau, Kaury Kucera, Karen
Anthony, Michel Ledizet & Yorgo Modis (2009). Crystal structure of dengue type 1 envelope protein in the postfusion conformation and its implication for receptor binding, membrane fusion and antibody recognition. J. Virol., 83,
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At Yale Modis was first
Assistant Professor (2005–2010) and then Associate Professor (2010–2014) of Molecular Biophysics & Biochemistry. In those capacities he carried out research that led to numerous publications on which he was corresponding author and/or principal
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Iva A. Tchasovnikarova, Richard T. Timms, Christopher H. Douse, Rhys C. Roberts, Gordon Dougan, Robert E. Kingston, Yorgo Modis & Paul J. Lehner (2017). Hyper-activation of HUSH complex function by
Charcot-Marie-Tooth disease mutation in MORC2. Nat. Genet., 9,
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Ming-Shih Hwang, Jérôme
Boulanger, Jonathan Howe, Anna Albecka, Mathias Pasche, Leila Mureşan & Yorgo Modis (2019). Endogenous MAVS oligomers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling. FEBS J., 286, 1543-1560.
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Emily V. Wong, Wenxiang Cao, Judit Vörös, Monique
Merchant, Yorgo Modis, David D. Hackney, Ben Montpetit & Enrique M. De La Cruz (2016). Pi release limits the intrinsic and RNA-stimulated ATPase cycles of DEAD-box protein 5 (Dbp5). J. Mol. Biol., 428,
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Ryuta Kanai, Kalipada Kar, Karen
Anthony, L. Hannah Gould, Michel Ledizet, Erol Fikrig, Wayne A. Marasco, Ray A. Koski & Yorgo Modis (2006). Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes. J. Virol., 80,
520:
Moshe Dessau, Daniel
Goldhill, Robert C. McBride, Paul E. Turner & Yorgo Modis (2012). Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet., 8,
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While at Harvard (1999–2005) Modis co-authored five publications that featured on the cover of international scientific journals. Among them was the subject of viral entry into host cells by the dengue virus, which became a cover story on
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Shmuel Willensky, Hagit Bar-Rogovsky, Eduardo A. Bignon, Nicole D. Tischler, Yorgo Modis & Moshe Dessau (2016). Crystal structure of glycoprotein C from a hantavirus in the post-fusion conformation. PLoS Pathog., 12,
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Danillo L.A. Espósito, Jennifer B. Nguyen, David C. DeWitt, Elizabeth Rhoades & Yorgo Modis (2015). Physico-chemical requirements and kinetics of membrane fusion of flavivirus-like particles. J. Gen. Virol, 96,
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Alvaro Arjona, Michel Ledizet, Karen Anthony, Nathalie Bonafé, Yorgo Modis, Terrence Town & Erol Fikrig (2007). West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J. Immunol., 179,
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Michael K. Fenwick, Yue Li, Stephen Almo, Peter Cresswell, Yorgo Modis & Steven E. Ealick (2017). Structural studies of viperin, an antiviral radical SAM enzyme (2017). Proc. Natl. Acad. Sci. U.S.A., 114,
436:
Bert van den Berg, William M. Clemons Jr., Ian Collinson, Yorgo Modis, Enno Hartmann, Stephen C. Harrison & Tom A. Rapoport (2004). X-ray structure of a protein-conducting channel. Nature, 427, 36-44
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Adel M. Nour, Yue Li, Joseph Wolenski & Yorgo Modis (2013). Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses. PLOS Pathog., 9, e1003585.
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Yorgo Modis, Steven Ogata, David Clements & Stephen C. Harrison (2005). Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J. Virol., 79, 1223-1231
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Yorgo Modis, Steven Ogata, David Clements & Stephen C. Harrison (2003). A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc. Natl. Acad. Sci. U.S.A., 100, 6986-6991
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Ian C. Berke, Xiong Yu, Yorgo Modis & Edward H. Egelman (2012). MDA5 assembles into a polar helical filament on double-stranded RNA. Proc. Natl. Acad. Sci. U.S.A., 109, 18437-41.
618:& James E. D. Thaventhiran (2018). A Type III Complement Factor D Deficiency: Structural insights for inhibition of the alternative pathway. J. Allergy Clin. Immun., 142, 311.
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Yue Li, Jimin Wang, Ryuta Kanai & Yorgo Modis (2013). Crystal structure of glycoprotein E2 from bovine viral diarrhea virus. Proc. Natl. Acad. Sci. U.S.A., 110, 6805-10.
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Yue Li, Ian C. Berke & Yorgo Modis (2012). DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature. EMBO J. 31, 919-31.
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Yorgo Modis, Steven Ogata, David Clements & Stephen C. Harrison (2004). Structure of the dengue virus envelope protein after membrane fusion. Nature, 427, 313-319.
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Ian C. Berke & Yorgo Modis (2012). MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J., 31, 1714-26.
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Moshe Dessau & Yorgo Modis (2013). Crystal structure of glycoprotein C from Rift Valley fever virus. Proc. Natl. Acad. Sci. U.S.A., 110, 1696-1701.
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In 2014 Modis accepted a position as Wellcome Trust Senior Research Fellow at University of Cambridge. He became the head of research group
318:. Two years later he was named University Reader in Virology and Immunology. In 2021 he was named Professor in Virology and Immunology.
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Yorgo Modis, Benes L. Trus & Stephen C. Harrison (2002). An atomic model of the papillomavirus capsid. EMBO J., 21, 4754-4762
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He has also been invited to, organized, or served as keynote speaker in over 100 seminars and conferences.
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In these capacities Modis has co-authored a number of publications as principal investigator.
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Wuhan: City of silence — Looking for answers in the place where coronavirus started
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in 1999. For the next six years he worked as a Postdoctoral Fellow with
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In July 2020 he contributed graphics of the COVID-19 virus to the
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A full list of his publications (around 70) can be found
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Senior Research Fellow at the Department of Medicine,
380:and Carole Gene Modis. He is the great-grandson of
297:. The work gave rise to an award-winning animation
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267:European Molecular Biology Laboratory
131:European Molecular Biology Laboratory
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288:Research and professional experience
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272:obtaining his Ph.D. from the
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237:Education and early life
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259:University of Cambridge
226:Molecular Immunity Unit
215:University of Cambridge
151:University of Cambridge
90:University of Cambridge
332:In May 2020 he helped
282:Harvard Medical School
139:Harvard Medical School
16:Professor of virology
699:Molecular biologists
376:Modis is the son of
338:Science Museum Group
384:and grandnephew of
300:Dengue Viral Fusion
278:Stephen C. Harrison
274:University of Leeds
241:Modis received his
163:Stephen C. Harrison
35:Yorgo Modis in 2016
263:Structural Biology
253:. He then studied
121:Structural Biology
45:Yorgo Eugene Modis
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679:1974 births
628:PMC6513760.
251:Switzerland
67:Switzerland
63:Nationality
56:Switzerland
23:Yorgo Modis
673:Categories
558:1702–1711.
392:References
270:Heidelberg
207:Immunology
135:Heidelberg
99:Heidelberg
588:e1005948.
578:7, 12752.
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245:from the
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484:4338-44.
350:BBC News
209:, and a
203:Virology
180:.mrc-lmb
92:(BA, MA)
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
