274:
49:
1574:
40:
344:
386:
InChI=1S/C25H44N2O/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4/h7,19-23,28H,6,8-17H2,1-5H3/t19-,20-,21-,22-,23-,24-,25-/m0/s1
722:
Counsell RE, Klimstra PD, Ranney RE (November 1962). "Hypocholesterolemic Agents. III.1N-Methyl-N-(dialkylamino)alkyl-17β-aminoandrost-5-en-3β-ol
Derivatives".
1185:
1638:
1619:
402:
812:
358:
1658:
1479:
1064:
64:
20,25-Diazacholesterol; 20,25-Azacholesterol; Azasterol; Diazasterol; SC-12937; DAC; IMD-760; 17β-(3-(Dimethylamino)propyl)methyl-
1612:
1533:
775:
652:
625:
598:
805:
409:
1605:
698:
520:. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The
423:
378:
1550:
843:
798:
505:
93:
1643:
1068:
834:
213:
242:
253:
436:
1494:
1653:
1393:
1359:
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1016:
456:(hypocholesteremic), which was marketed previously, but has since been discontinued. It is also an
269:
17:
1538:
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1413:
1388:
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1101:
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956:
883:
71:
1403:
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202:
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222:
528:
production, steroid hormones being synthesized from cholesterol. Due to prevention of the
8:
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567:
479:
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151:
142:
78:
1433:
879:
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1428:
1097:
1054:
952:
771:
739:
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648:
621:
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182:
590:
The
Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies
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501:
290:
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557:
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48:
31:
1519:
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1120:
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825:
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509:
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1514:
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860:
562:
529:
320:
193:
1225:
912:
865:
855:
617:
Concise
Dictionary of Pharmacological Agents: Properties and Synonyms
168:
532:
of desmosterol, the drug causes it to accumulate, in turn producing
1509:
1504:
1484:
1256:
1029:
921:
494:
343:
1351:
1167:
39:
129:)-17--10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1
1039:
948:
847:
487:
475:
467:
233:
939:
334:
258:
541:
524:
effects of the drug in birds are mediated by inhibition of
490:
457:
640:
424:
620:. Springer Science & Business Media. pp. 43–.
721:
437:
724:Journal of Medicinal and Pharmaceutical Chemistry
1630:
764:"Lipids in normal and pathological desquamation"
181:
820:
757:
755:
753:
672:
150:
668:
666:
664:
1613:
806:
641:William Andrew Publishing (22 October 2013).
634:
607:
750:
715:
673:Singh H, Kapoor VK, Paul D (January 1979).
661:
1639:24-Dehydrocholesterol reductase inhibitors
1620:
1606:
813:
799:
613:
272:
201:
1480:Magnesium pyridoxal 5-phosphate glutamate
647:(3rd ed.). Elsevier. pp. 463–.
644:Pharmaceutical Manufacturing Encyclopedia
429:Tooltip International Nonproprietary Name
221:
761:
366:C12CC3(1CC2N(C)CCCN(C)C)CC=C43(CC(C4)O)C
768:Advances in Lipid Research: Skin Lipids
580:
268:
14:
1631:
614:Morton IK, Hall JM (31 October 1999).
794:
241:
1568:
586:
172:
24:
675:"Heterosteroids and drug research"
442:Tooltip United States Adopted Name
25:
1670:
844:Cholesterol absorption inhibitors
1659:Cardiovascular system drug stubs
1572:
307:
301:
47:
38:
762:Williams ML (21 January 2016).
679:Progress in Medicinal Chemistry
506:24-dehydrocholesterol reductase
391:Key:FMTFZYKYVZBISL-HUVRVWIJSA-N
770:. Elsevier. pp. 218–220.
313:
295:
13:
1:
691:10.1016/s0079-6468(08)70187-5
573:
1592:. You can help Knowledge by
7:
593:. Springer. pp. 110–.
587:Elks J (14 November 2014).
551:
133:-cyclopentaphenanthren-3-ol
10:
1675:
1567:
508:(24-DHCR), preventing the
285:Chemical and physical data
1528:
1495:Omega−3-acid ethyl esters
1442:
1381:
1350:
1312:
1269:
1249:
1166:
1156:
1147:
1119:
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1063:
1014:
947:
938:
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470:populations via inducing
454:cholesterol-lowering drug
433:azacosterol hydrochloride
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252:
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212:
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141:
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70:
60:
55:
46:
37:
1584:article relating to the
1394:Bempedoic acid/ezetimibe
1015:Niacin and derivatives (
493:have been replaced with
66:amino)androst-5-en-3β-ol
1419:Fenofibrate/simvastatin
1414:Fenofibrate/pravastatin
1389:Amlodipine/atorvastatin
500:Azacosterol acts as an
1404:Ezetimibe/rosuvastatin
1399:Ezetimibe/atorvastatin
876:Bile acid sequestrants
540:, particularly of the
450:20,25-diazacholesterol
1586:cardiovascular system
1409:Ezetimibe/simvastatin
822:Lipid-lowering agents
766:. In Elias PM (ed.).
1644:Hypolipidemic agents
1450:Alipogene tiparvovec
1176:Aluminium clofibrate
1035:Aluminium nicotinate
1186:Choline fenofibrate
736:10.1021/jm01241a014
568:X-linked ichthyosis
34:
1555:Never to phase III
1434:Niacin/simvastatin
1424:Niacin/laropiprant
30:
1601:
1600:
1565:
1564:
1429:Niacin/lovastatin
1377:
1376:
1265:
1264:
1143:
1142:
1098:ATP citrate lyase
1055:Nicotinyl alcohol
953:HMG-CoA reductase
934:
933:
777:978-1-4832-1545-7
654:978-0-8155-1856-3
627:978-0-7514-0499-9
600:978-1-4757-2085-3
463:used to control
448:), also known as
417:
416:
345:Interactive image
254:CompTox Dashboard
27:Chemical compound
16:(Redirected from
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1622:
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1314:PCSK9 inhibitors
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584:
474:. The drug is a
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1654:Withdrawn drugs
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1627:
1626:
1566:
1561:
1560:
1545:Clinical trials
1524:
1438:
1373:
1346:
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1271:CETP inhibitors
1261:
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1130:Dextrothyroxine
1115:
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558:Desmosterolosis
554:
526:steroid hormone
441:
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403:(what is this?)
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1111:Bempedoic acid
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730:(6): 1224–33.
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538:hyperkeratosis
461:chemosterilant
444:) (brand name
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1199:
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1179:
1177:
1174:
1173:
1171:
1169:
1165:
1162:
1159:
1158:PPAR agonists
1155:
1152:
1150:
1149:Blood vessels
1146:
1136:
1133:
1131:
1128:
1127:
1125:
1122:
1121:Thyromimetics
1118:
1112:
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964:
963:
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950:
946:
943:
941:
937:
927:
923:
919:
918:Soluble fiber
916:
914:
911:
909:
908:Colestyramine
906:
904:
901:
899:
896:
894:
891:
890:
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827:
823:
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789:
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741:
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700:9780720406672
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629:
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583:
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569:
566:
564:
561:
559:
556:
555:
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547:
543:
539:
535:
531:
527:
523:
522:antifertility
519:
515:
511:
507:
503:
498:
496:
492:
489:
486:in which two
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481:
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469:
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318:
294:
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288:
283:
275:
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270:DTXSID1058509
267:
266:
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255:
251:
244:
243:ChEMBL1615357
240:
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224:
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158:hydrochloride
153:
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75:
69:
63:
59:
56:Clinical data
54:
50:
45:
41:
36:
19:
1594:expanding it
1579:
1520:Volanesorsen
1454:
1382:Combinations
1354:inhibitors (
1196:Clinofibrate
1191:Ciprofibrate
1100:inhibitors (
1067:inhibitors (
1050:Nicofuranose
1001:Rosuvastatin
991:Pitavastatin
971:Cerivastatin
966:Atorvastatin
787:
767:
727:
723:
717:
682:
678:
643:
636:
616:
609:
589:
582:
534:side effects
499:
449:
445:
432:
419:
418:
407:
401:
130:
126:
122:
118:
114:
110:
106:
102:
1541:from market
1500:Policosanol
1475:Lapaquistat
1455:Azacosterol
1332:Bococizumab
1304:Torcetrapib
1299:Obicetrapib
1294:Evacetrapib
1289:Dalcetrapib
1284:Anacetrapib
1236:Ronifibrate
1231:Pemafibrate
1221:Gemfibrozil
1216:Fenofibrate
1181:Bezafibrate
1088:Mitratapide
1078:Dirlotapide
1006:Simvastatin
996:Pravastatin
976:Fluvastatin
926:glucomannan
893:Colesevelam
518:desmosterol
514:cholesterol
484:cholesterol
420:Azacosterol
328: g·mol
156:1249-84-9 (
85:Identifiers
61:Other names
32:Azacosterol
1633:Categories
1515:Triparanol
1490:Mipomersen
1470:Darapladib
1465:Benfluorex
1460:Azalanstat
1369:Evinacumab
1342:Inclisiran
1337:Evolocumab
1327:Alirocumab
1241:Simfibrate
1211:Etofibrate
1206:Clofibride
1201:Clofibrate
1135:Resmetirom
1083:Lomitapide
1045:Niceritrol
986:Mevastatin
981:Lovastatin
903:Colestipol
898:Colestilan
861:Hyzetimibe
685:: 35–149.
574:References
563:Triparanol
530:metabolism
480:derivative
333:3D model (
321:Molar mass
223:EPT876J73A
194:ChemSpider
143:CAS Number
94:IUPAC name
1551:Phase III
1539:Withdrawn
1226:Nafenopin
913:Colextran
866:SCH-48461
856:Ezetimibe
510:formation
502:inhibitor
472:sterility
72:Routes of
1510:Tiadenol
1505:Probucol
1485:Meglutol
1257:GW501516
1168:Fibrates
1030:Acipimox
922:psyllium
920:such as
835:GI tract
744:14056455
552:See also
536:such as
495:nitrogen
446:Ornitrol
410:(verify)
183:10023199
152:313-05-3
79:By mouth
18:Ornitrol
1649:Sterols
1352:ANGPTL3
949:Statins
497:atoms.
452:, is a
326:388.640
291:Formula
203:8198772
169:PubChem
1534:WHO-EM
1250:Others
1123:(VLDL)
1040:Niacin
880:resins
848:NPC1L1
774:
742:
707:
697:
651:
624:
597:
488:carbon
476:sterol
468:pigeon
431:), or
359:SMILES
234:ChEMBL
1588:is a
1580:This
1443:Other
1160:(LDL)
940:Liver
709:95596
546:soles
542:palms
516:from
491:atoms
458:avian
379:InChI
335:JSmol
1590:stub
1582:drug
1069:VLDL
1065:MTTP
1019:and
924:and
772:ISBN
740:PMID
705:PMID
695:ISBN
649:ISBN
622:ISBN
595:ISBN
544:and
478:and
465:pest
438:USAN
214:UNII
1360:HDL
1356:LDL
1318:LDL
1275:HDL
1102:LDL
1021:LDL
1017:HDL
957:LDL
884:LDL
826:C10
732:doi
687:doi
512:of
504:of
482:of
425:INN
259:EPA
173:CID
125:,17
121:,14
117:,13
113:,10
1635::
1547::
955:,
846:,
752:^
738:.
728:91
726:.
703:.
693:.
683:16
681:.
677:.
663:^
548:.
305:44
299:25
109:,9
105:,8
101:(3
1621:e
1614:t
1607:v
1596:.
1362:)
1358:/
1320:)
1316:(
1277:)
1273:(
1104:)
1071:)
1023:)
959:)
951:(
886:)
882:(
878:/
828:)
824:(
814:e
807:t
800:v
780:.
746:.
734::
711:.
689::
657:.
630:.
603:.
435:(
422:(
337:)
314:O
311:2
308:N
302:H
296:C
261:)
257:(
160:)
131:H
127:S
123:S
119:S
115:R
111:S
107:R
103:S
20:)
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