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is expressed on the outer surface of the apoptotic cells, which is recognized by multiple receptors. The tangible body macrophages express: tyrosine kinase Mer, the milk fat globule epidermal growth factor 8 and Tim-4, all of which supports the engulfment of the apoptotic cells into the macrophages.
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Macrophages are also present in the T cell area of the white pulp but their role is less well understood. This population of macrophages can be found in all the other T cell zones of the secondary lymphoid organs. It is possible that these macrophages are descendants of patrolling
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populations; however, not much is known about these macrophage populations in terms of their origin and lifespan. These macrophages are not unique to the spleen but instead make up an integral part of the lymphoid parts of all
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and are subsequently cleared by the macrophages in the germinal centre. During intensive germinal centre reactions, this process is obvious due to the presence of the large macrophages in the germinal centre, known as
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that entered the white pulp from the blood. Due to them being positioned alongside T cells, it is suggested that these macrophages have a role in
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exists between the white pulp and red pulp. It is located farther away from the central arteriole, in proximity to the
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In the B cell follicles, the macrophages are important in clearing the apoptotic B cells that occur during the
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on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of
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242:. Some of the white pulp's macrophages are of a specialized kind known as metallophilic macrophages.
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are produced in this zone. These molecules play a role in opsonization of extracellular organisms,
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192:(PALS) are typically associated with the arteriole supply of the spleen; they contain
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Specifically, the white pulp encompasses several areas with distinct functions:
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386:"Innate Immune Functions of Macrophage Subpopulations in the Spleen"
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Anatomy
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49:. (Lymphatic nodule labeled at center right.)
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384:den Haan, Joke M.M.; Kraal, Georg (2012).
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45:Transverse section of a portion of the
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203:are located between the PALS and the
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333:Mucosa-associated lymphoid tissue
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190:periarteriolar lymphoid sheaths
443:First aid to USMLE step 1 2018
199:Lymph follicles with dividing
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247:Macrophages in the white pulp
845:. You can help Knowledge by
837:This article related to the
16:Type of tissue in the spleen
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362:of the 20th edition of
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275:reaction in the process of
259:follicles contain discrete
207:bordering on the red pulp.
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107:noduli lymphoidei splenici
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705:Waldeyer's tonsillar ring
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460:Histology image: 07703loa
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733:High endothelial venules
309:or the removal of dying
232:antigen-presenting cells
554:Hematopoietic stem cell
902:Lymphatic system stubs
150:Anatomical terminology
277:somatic hypermutation
217:encapsulated bacteria
572:Hassall's corpuscles
307:antigen presentation
655:Trabecular arteries
294:phosphatidylserine
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715:Lymph nodes
546:Bone marrow
311:lymphocytes
240:macrophages
96:Identifiers
886:Categories
690:Pharyngeal
635:White pulp
611:Trabeculae
344:References
323:Lymph node
261:macrophage
167:White pulp
22:White pulp
410:1662-8128
360:page 1285
303:monocytes
285:apoptosis
61:Precursor
680:Palatine
618:Red pulp
428:22327291
317:See also
228:red pulp
175:red pulp
66:mesoderm
816:Anatomy
740:B cells
728:T cells
685:Lingual
672:Tonsils
419:6741446
55:Details
802:Portal
602:Parts
595:Spleen
564:Thymus
476:, and
468:(from
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368:(1918)
338:Spleen
257:B cell
253:T cell
171:spleen
73:Artery
47:spleen
33:Spleen
841:is a
695:Tubal
606:Hilum
358:from
154:[
143:62805
102:Latin
843:stub
775:GALT
767:MALT
424:PMID
406:ISSN
279:and
251:The
238:and
222:The
213:IgG2
211:and
188:The
131:5176
114:TA98
85:Vein
414:PMC
398:doi
209:IgM
138:FMA
126:TA2
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