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Vertebrate mitochondrial code

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Ki, J. S.; Hwang, D. S.; Park, T. J.; Han, S. H.; Lee, J. S. (2009). "A comparative analysis of the complete mitochondrial genome of the Eurasian otter Lutra lutra (Carnivora; Mustelidae)".
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W. R. Hou, Y. Chen, X. Wu, J. C. Hu, Z. S. Peng, J. Yang, Z. X. Tang, C. Q. Zhou, Y. M. Li, S. K. Yang, Y. J. Du, L. L. Kong, Z. L. Ren, H. Y. Zhang and S. S. Shuai (December 2006).
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S. Osawa, T. Ohama, T. H. Jukes and K. Watanabe (September 1989). "Evolution of the mitochondrial genetic code. I. Origin of AGR serine and stop codons in metazoan mitochondria".
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Oh, D. J.; Kim, J. Y.; Lee, J. A.; Yoon, W. J.; Park, S. Y.; Jung, Y. H. (2007). "Complete mitochondrial genome of the rabbitfish Siganus fuscescens (Perciformes, Siganidae)".
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R J Temperley; R Richter; S Dennerlein; R N Lightowlers; Z M Chrzanowska-Lightowlers (January 2010). "Hungry codons promote frameshifting in human mitochondrial ribosomes".
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P. Desjardins & R. Morais (February 1991). "Nucleotide sequence and evolution of coding and noncoding regions of a quail mitochondrial genome".
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early in vertebrate evolution. However, at least in humans it has now been shown that AGA and AGG sequences are not recognized as
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Nakamoto T (March 2009). "Evolution and the universality of the mechanism of initiation of protein synthesis".
988:"A complete mitochondrial genome sequence of Asian black bear Sichuan subspecies (Ursus thibetanus mupinensis)" 1250: 1240: 1245: 56: 583:
The codon AUG both codes for methionine and serves as an initiation site: the first AUG in an
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Temperley, R. J.; Wydro, M; Lightowlers, R. N.; Chrzanowska-Lightowlers, Z. M. (2010).
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frameshift occurs at the AGA and AGG codons predicted to terminate the CO1 and ND6
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ending in U or UA, which become complete termination codons (UAA) upon subsequent
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An alternative genetic code found in the mitochondrial genome of vertebrates
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Mitochondrial genes in some vertebrates (including humans) have incomplete
32: 28: 1199: 850: 764: 91: 63:(ORFs), and consequently both ORFs terminate in the standard UAG codon. 1191: 842: 447: 427: 387: 368: 238: 229: 72: 48: 36: 1003: 377: 331: 285: 772: 294: 187: 178: 508: 490: 276: 218: 481: 439: 396: 169: 756: 584: 587:'s coding region is where translation into protein begins. 748: 1169: 47:
AGA and AGG were thought to have become mitochondrial
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Biochimica et Biophysica Acta (BBA) - Bioenergetics
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page compiled by Andrzej Elzanowski and Jim Ostell.
804:This article contains public domain text from the 380:         1232: 741: 1091: 1048: 1034:: CS1 maint: multiple names: authors list ( 871:: CS1 maint: multiple names: authors list ( 1128: 1134: 1214: 1011: 962: 66: 930: 814: 577: 879: 1233: 1163: 578: 82: 13: 979: 592:Differences from the standard code 14: 1262: 1085: 1042: 1: 798: 742:Alternative initiation codons 21:vertebrate mitochondrial code 955:10.1016/j.bbabio.2010.02.036 42: 7: 786: 119:Mitochondrial genetic code 10: 1267: 1149:10.1016/j.gene.2008.11.001 1106:10.1007/s11033-009-9641-0 1094:Molecular Biology Reports 1063:10.1080/10425170701248525 543: 506: 497: 488: 479: 473: 446: 437: 425: 394: 385: 375: 366: 360: 329: 292: 283: 274: 265: 241:     236: 228: 216: 185: 176: 167: 158: 152: 147: 144: 141: 138: 131: 128: 123: 112:Termination: stop codon 908:10.1126/science.1180674 95:biochemical properties 67:Incomplete stop codons 793:List of genetic codes 1251:Protein biosynthesis 1184:1991JMolE..32..153D 900:2010Sci...327..301T 835:1989JMolE..29..202O 597: 120: 61:open reading frames 23:(translation table 1241:Molecular genetics 1192:10.1007/bf02515387 843:10.1007/bf02100203 596: 118: 53:termination codons 1221:The Genetic Codes 1004:10.7150/ijbs.3.85 739: 738: 574: 573: 116: 115: 83:Translation table 1258: 1223: 1218: 1212: 1211: 1167: 1161: 1160: 1132: 1126: 1125: 1089: 1083: 1082: 1046: 1040: 1039: 1033: 1025: 1015: 983: 977: 976: 966: 934: 928: 927: 883: 877: 876: 870: 862: 818: 735: 732: 725: 722: 717: 712: 705: 702: 695: 692: 687: 682: 675: 672: 665: 662: 657: 652: 645: 642: 635: 632: 627: 622: 598: 595: 582: 121: 117: 87: 86: 1266: 1265: 1261: 1260: 1259: 1257: 1256: 1255: 1246:Gene expression 1231: 1230: 1227: 1226: 1219: 1215: 1168: 1164: 1133: 1129: 1090: 1086: 1047: 1043: 1027: 1026: 984: 980: 949:(6–7): 1081–5. 935: 931: 884: 880: 864: 863: 819: 815: 801: 789: 768:: AUA, AUU, AUC 744: 733: 730: 723: 720: 715: 710: 703: 700: 693: 690: 685: 680: 673: 670: 663: 660: 655: 650: 643: 640: 633: 630: 625: 620: 594: 133: 125: 85: 77:polyadenylation 69: 45: 17: 12: 11: 5: 1264: 1254: 1253: 1248: 1243: 1225: 1224: 1213: 1178:(2): 153–161. 1162: 1127: 1100:(4): 1943–55. 1084: 1057:(4): 295–301. 1041: 992:Int J Biol Sci 978: 929: 878: 812: 811: 810: 809: 800: 797: 796: 795: 788: 785: 784: 783: 769: 761: 753: 743: 740: 737: 736: 728: 726: 718: 713: 707: 706: 698: 696: 688: 683: 677: 676: 668: 666: 658: 653: 647: 646: 638: 636: 628: 623: 617: 616: 610: 608: 605: 602: 593: 590: 589: 588: 572: 571: 568: 565: 562: 559: 555: 554: 551: 548: 542: 539: 536: 532: 531: 528: 525: 522: 519: 515: 514: 511: 505: 502: 496: 493: 487: 484: 478: 475: 471: 470: 467: 464: 461: 458: 454: 453: 450: 445: 442: 436: 433: 430: 424: 420: 419: 416: 413: 410: 407: 403: 402: 399: 393: 390: 384: 381: 374: 371: 365: 362: 358: 357: 354: 351: 348: 345: 341: 340: 337: 334: 328: 325: 322: 318: 317: 314: 311: 308: 305: 301: 300: 297: 291: 288: 282: 279: 273: 270: 267: 263: 262: 259: 256: 253: 250: 246: 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637: 629: 624: 619: 618: 614: 613:Standard code 611: 609: 607:This code (2) 606: 603: 600: 599: 586: 581: 580: 576: 575: 569: 566: 563: 560: 557: 556: 552: 549: 547: 546:Glutamic acid 540: 537: 534: 533: 529: 526: 523: 520: 517: 516: 512: 510: 503: 501: 500:Aspartic acid 494: 492: 485: 483: 476: 472: 468: 465: 462: 459: 456: 455: 451: 449: 443: 441: 434: 431: 429: 422: 421: 417: 414: 411: 408: 405: 404: 400: 398: 391: 389: 382: 379: 372: 370: 363: 359: 355: 352: 349: 346: 343: 342: 338: 335: 333: 326: 323: 320: 319: 315: 312: 309: 306: 303: 302: 298: 296: 289: 287: 280: 278: 271: 268: 264: 260: 257: 254: 251: 248: 247: 243: 240: 233: 231: 225: 222: 220: 213: 212: 208: 205: 202: 199: 196: 195: 191: 189: 182: 180: 173: 171: 164: 162: 161:Phenylalanine 155: 151: 137: 122: 111: 109: 106: 103: 100: 97: 94: 93: 89: 88: 80: 78: 74: 64: 62: 58: 54: 50: 40: 38: 34: 31:found in the 30: 26: 22: 1228: 1216: 1175: 1171: 1165: 1143:(1–2): 1–6. 1140: 1136: 1130: 1097: 1093: 1087: 1054: 1051:DNA Sequence 1050: 1044: 1030:cite journal 998:(2): 85–90. 995: 991: 981: 946: 942: 932: 891: 887: 881: 867:cite journal 829:(3): 202–7. 826: 822: 816: 777: 771: 763: 755: 747: 579: 90: 70: 57:mitoribosome 46: 33:mitochondria 29:genetic code 24: 20: 18: 92:Amino acids 73:stop codons 49:stop codons 1235:Categories 1172:J Mol Evol 823:J Mol Evol 799:References 782:: also GUG 760:: AUA, AUU 731:STOP = Ter 661:STOP = Ter 631:STOP = Ter 604:RNA codons 601:DNA codons 428:Methionine 388:Asparagine 369:Isoleucine 239:Tryptophan 37:vertebrata 924:206522983 378:Threonine 332:Glutamine 286:Histidine 129:2nd base 98:nonpolar 43:Evolution 27:) is the 1157:19056476 1122:24233602 1114:19757186 1079:38458668 1071:17541835 1022:17205108 973:20211597 916:20075246 859:21051869 787:See also 773:Coturnix 544:(Glu/E) 507:(Gly/G) 498:(Asp/D) 489:(Ala/A) 480:(Val/V) 438:(Lys/K) 426:(Met/M) 395:(Ser/S) 386:(Asn/N) 376:(Thr/T) 367:(Ile/I) 330:(Gln/Q) 295:Arginine 293:(Arg/R) 284:(His/H) 275:(Pro/P) 237:(Trp/W) 217:(Leu/L) 188:Cysteine 186:(Cys/C) 179:Tyrosine 177:(Tyr/Y) 168:(Ser/S) 159:(Phe/F) 1208:1974138 1200:1706782 1180:Bibcode 1013:1752227 964:3003153 896:Bibcode 888:Science 851:2506356 831:Bibcode 509:Glycine 491:Alanine 277:Proline 219:Leucine 107:acidic 55:. A -1 35:of all 1206:  1198:  1155:  1120:  1112:  1077:  1069:  1020:  1010:  971:  961:  922:  914:  857:  849:  779:Gallus 482:Valine 440:Lysine 397:Serine 170:Serine 104:basic 101:polar 1204:S2CID 1118:S2CID 1075:S2CID 920:S2CID 855:S2CID 752:: AUA 134:base 126:base 1196:PMID 1153:PMID 1137:Gene 1110:PMID 1067:PMID 1036:link 1018:PMID 969:PMID 947:1797 912:PMID 873:link 847:PMID 806:NCBI 757:Homo 615:(1) 585:mRNA 567:GGG 564:GAG 561:GCG 558:GUG 550:GGA 541:GAA 538:GCA 535:GUA 527:GGC 524:GAC 521:GCC 518:GUC 504:GGU 495:GAU 486:GCU 477:GUU 466:AGG 463:AAG 460:ACG 457:AUG 448:Stop 444:AGA 435:AAA 432:ACA 423:AUA 415:AGC 412:AAC 409:ACC 406:AUC 392:AGU 383:AAU 373:ACU 364:AUU 353:CGG 350:CAG 347:CCG 344:CUG 336:CGA 327:CAA 324:CCA 321:CUA 313:CGC 310:CAC 307:CCC 304:CUC 290:CGU 281:CAU 272:CCU 269:CUU 258:UGG 255:UAG 252:UCG 249:UUG 234:UGA 230:Stop 226:UAA 223:UCA 214:UUA 206:UGC 203:UAC 200:UCC 197:UUC 183:UGU 174:UAU 165:UCU 156:UUU 19:The 1188:doi 1145:doi 1141:432 1102:doi 1059:doi 1008:PMC 1000:doi 959:PMC 951:doi 904:doi 892:327 839:doi 765:Mus 749:Bos 734:(*) 724:(W) 721:Trp 716:UGA 711:TGA 704:(I) 701:Ile 694:(M) 691:Met 686:AUA 681:ATA 674:(R) 671:Arg 664:(*) 656:AGG 651:AGG 644:(R) 641:Arg 634:(*) 626:AGA 621:AGA 132:3rd 124:1st 1237:: 1202:. 1194:. 1186:. 1176:32 1174:. 1151:. 1139:. 1116:. 1108:. 1098:37 1096:. 1073:. 1065:. 1055:18 1053:. 1032:}} 1028:{{ 1016:. 1006:. 994:. 990:. 967:. 957:. 945:. 941:. 918:. 910:. 902:. 890:. 869:}} 865:{{ 853:. 845:. 837:. 827:29 825:. 776:, 570:G 553:A 530:C 513:U 474:G 469:G 452:A 418:C 401:U 361:A 356:G 339:A 316:C 299:U 266:C 261:G 244:A 209:C 192:U 153:U 148:G 145:A 142:C 139:U 79:. 39:. 1210:. 1190:: 1182:: 1159:. 1147:: 1124:. 1104:: 1081:. 1061:: 1038:) 1024:. 1002:: 996:3 975:. 953:: 926:. 906:: 898:: 875:) 861:. 841:: 833:: 25:2

Index

genetic code
mitochondria
vertebrata
stop codons
termination codons
mitoribosome
open reading frames
stop codons
polyadenylation
Amino acids
Phenylalanine
Serine
Tyrosine
Cysteine
Leucine
Stop
Tryptophan
Proline
Histidine
Arginine
Glutamine
Isoleucine
Threonine
Asparagine
Serine
Methionine
Lysine
Stop
Valine
Alanine

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