Knowledge

Upper gastrointestinal bleeding

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pump inhibitors, if they have not been started earlier, are recommended in those in whom high risk signs for bleeding are found. It is also recommended that people with high risk signs are kept in hospital for at least 72 hours. Blood transfusions are not generally recommended to correct anemia, but blood transfusions are recommended if the person is not stable (cardiovascular system instability). Oral iron can be used, but this can lead to problems with compliance, tolerance, darkening stools which may mask evidence of rebleeding and tends to be slow, especially if used in conjunction with proton pump inhibitors.
519:. A positive aspirate is more helpful than a negative aspirate (If the aspirate is positive, an upper gastrointestinal bleed is likely; if the aspirate is negative, the source of a gastrointestinal bleed is probably, but not certainly, lower). A smaller study found a sensitivity of 79% and specificity of 55%, somewhat opposite results from Witting. The accuracy of the aspirate is improved by using the Gastroccult test. 526:(Hematest reagent tablets and Bili-Labstix) or guaiac (Hemoccult and Gastroccult). There is some evidence that orthotolidine-based tests more sensitive than specific, the Hemoccult test's sensitivity reduced by the acidic environment; and the Gastroccult test be the most accurate. The sensitivity, specificity, positive predictive value, and negative predictive value have been reported as follows: 777: 40: 315: 796:
before endoscopy can decrease the amount of blood in the stomach and thus improve the operators view. This erythromycin treatment may lead to a small decrease in the need for a blood transfusion, but the overall balance of how effective erythromycin is compared to potential risks is not clear. Proton
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medications are often given in the emergent setting before an endoscopy and may reduce the need for an endoscopic haemotstatic treatment. Proton pump inhibitors decrease gastric acid production. There is insufficient evidence to determine if proton pump inhibitors decrease death rates, re-bleeding
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Barkun, AN; Almadi, M; Kuipers, EJ; Laine, L; Sung, J; Tse, F; Leontiadis, GI; Abraham, NS; Calvet, X; Chan, FKL; Douketis, J; Enns, R; Gralnek, IM; Jairath, V; Jensen, D; Lau, J; Lip, GYH; Loffroy, R; Maluf-Filho, F; Meltzer, AC; Reddy, N; Saltzman, JR; Marshall, JK; Bardou, M (22 October 2019).
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Holman used simulated gastric specimens and found the Hemoccult test to have significant problems with non-specificity and false-positive results, whereas the Gastroccult test was very accurate. Holman found that by 120 seconds after the developer was applied, the Hemoccult test was positive on
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Barkun, Alan N.; Almadi, Majid; Kuipers, Ernst J.; Laine, Loren; Sung, Joseph; Tse, Frances; Leontiadis, Grigorios I.; Abraham, Neena S.; Calvet, Xavier; Chan, Francis K.L.; Douketis, James; Enns, Robert; Gralnek, Ian M.; Jairath, Vipul; Jensen, Dennis; Lau, James; Lip, Gregory Y.H.; Loffroy,
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are believed to be equivalent for peptic ulcer bleeding. In people with a confirmed peptic ulcer, proton pump inhibitors do not reduce death rates, later bleeding events, or need for surgery. They may decrease signs of bleeding at endoscopy however. In those with less severe disease and where
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bleeding score found 16% of people presenting with upper gastrointestinal bleed had Glasgow-Blatchford score of "0", considered low. Among these people there were no deaths or interventions needed and they were able to be effectively treated in an outpatient setting.
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Upper gastrointestinal bleeding affects around 50 to 150 people per 100,000 a year. It represents over 50% of cases of gastrointestinal bleeding. A 1995 UK study found an estimated mortality risk of 11% in those admitted to hospital for gastrointestinal bleeding.
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Depending on its severity, upper gastrointestinal bleeding may carry an estimated mortality risk of 11%. However, survival has improved to about 2 percent, likely as a result of improvements in medical therapy and endoscopic control of bleeding.
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Graber CJ, et al. (2007). "A Stitch in Time — A 64-year-old man with a history of coronary artery disease and peripheral vascular disease was admitted to the hospital with a several-month history of fevers, chills, and fatigue".
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events, or the need for surgical interventions. After the initial resuscitation has been completed, treatment is instigated to limit the likelihood of re-bleeds and correct any anemia that the bleeding may have caused. Those with a
231:(maroon-coloured stool) if the hemorrhage is severe. The presentation of bleeding depends on the amount and location of hemorrhage. A person with upper gastrointestinal bleeding may also present with complications of 499:
The strongest predictors of an upper gastrointestinal bleed are black stool, age <50 years, and blood urea nitrogen/creatinine ratio 30 or more. The diagnosis of upper gastrointestinal bleeding is assumed when
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Witting MD, Magder L, Heins AE, Mattu A, Granja CA, Baumgarten M; Magder; Heins; Mattu; Granja; Baumgarten (2004). "Usefulness and validity of diagnostic nasogastric aspiration in patients without hematemesis".
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The predictive values cited are based on the prevalences of upper gastrointestinal bleeding in the corresponding studies. A clinical calculator can be used to generate predictive values for other prevalences.
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Witting MD, Magder L, Heins AE, Mattu A, Granja CA, Baumgarten M; Magder; Heins; Mattu; Granja; Baumgarten (2006). "ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis".
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Sierra J, Kalangos A, Faidutti B, Christenson JT; Kalangos; Faidutti; Christenson (2003). "Aorto-enteric fistula is a serious complication to aortic surgery. Modern trends in diagnosis and therapy".
450:. Fistulae are usually secondary to prior vascular surgery and usually occur at the proximal anastomosis at the third or fourth portion of the duodenum where it is retroperitoneal and near the aorta. 1411:
Stanley AJ, Ashley D, Dalton HR, et al. (January 2009). "Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation".
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beginning with airway management and fluid resuscitation using either intravenous fluids and or blood. A number of medications may improve outcomes depending on the source of the bleeding.
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can help determine the location (source) of bleeding and help understand the best initial diagnostic and treatment plan. Nasogastric aspirate has a sensitivity of 42%, specificity 91%,
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Determining whether blood is in gastric contents, either vomited or aspirated specimens, may be a challenge when determining the source of the hemorrhage. Slide tests are based on
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Cai, Jennifer X.; Saltzman, John R. (July 2018). "Initial Assessment, Risk Stratification, and Early Management of Acute Nonvariceal Upper Gastrointestinal Hemorrhage".
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There are many causes for upper gastrointestinal hemorrhage. Causes are usually anatomically divided into their location in the upper gastrointestinal tract.
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Villanueva, CĂ ndid; Colomo, Alan; Bosch, Alba; ConcepciĂłn, Mar; Hernandez-Gea, Virginia; Aracil, Carles; Graupera, Isabel; Poca, MarĂ­a; et al. (2013).
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Ernst AA, Haynes ML, Nick TG, Weiss SJ; Haynes; Nick; Weiss (1999). "Usefulness of the blood urea nitrogen/creatinine ratio in gastrointestinal bleeding".
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Holman JS, Shwed JA; Shwed (1992). "Influence of sucralfate on the detection of occult blood in simulated gastric fluid by two screening tests".
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64%, positive predictive value 92% and overall accuracy of 66% in differentiating upper gastrointestinal bleeding from bleeding distal to the
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Romaric; Maluf-Filho, Fauze; Meltzer, Andrew C.; Reddy, Nageshwar; Saltzman, John R.; Marshall, John K.; Bardou, Marc (22 October 2019).
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Cendan JC, Thomas JB, Seeger JM; Thomas Jb; Seeger (2004). "Twenty-one cases of aortoenteric fistula: lessons for the general surgeon".
2337: 826:. In the absence of hematemesis, 40% to 50% of people in the emergency department with gastrointestinal bleeding have an upper source. 3492: 1300:
Cuellar RE, Gavaler JS, Alexander JA, et al. (1990). "Gastrointestinal tract hemorrhage. The value of a nasogastric aspirate".
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greater than 7 to 8 g/dL and only moderate bleeding. If the INR is greater than 1.5 to 1.8 correction with fresh frozen plasma,
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AdĂŁo, Diego; Gois, Aecio FT; Pacheco, Rafael L; Pimentel, Carolina FMG; Riera, Rachel (2023-02-01). Cochrane Gut Group (ed.).
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or non-variceal sources of upper gastrointestinal hemorrhage, as the two have different treatment algorithms and prognosis.
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Kanno, Takeshi; Yuan, Yuhong; Tse, Frances; Howden, Colin W.; Moayyedi, Paul; Leontiadis, Grigorios I. (2022-01-07).
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Jairath, V; Barkun, AN (October 2011). "The overall approach to the management of upper gastrointestinal bleeding".
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Upper endoscopy within 24 hours is the recommended treatment. The benefits versus risks of placing a
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while recommended for variceal bleeding have not been found to be of general use for non-variceal bleeds.
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might be effective to reduce mortality, but the evidence for this is weak. But the evidence is promising.
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Rosenthal P, Thompson J, Singh M; Thompson; Singh (1984). "Detection of occult blood in gastric juice".
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may be used for the prevention of re-bleeding. If bleeding continues then balloon tamponade with a
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with gastrointestinal bleeding have an upper source. The diagnosis is easier when the people have
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may be used in an attempt to mechanically compress the varices. This may then be followed by a
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Bennett, Cathy; Klingenberg, Sarah Louise; Langholz, Ebbe; Gluud, Lise Lotte (2014-11-21).
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Iron is increasingly used in these cases to improve patient outcomes and void blood usage.
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for variceal bleeding) may be used. Recurrent or refractory bleeding may lead to need for
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Cat, TB; Liu-DeRyke, X (September 2010). "Medical management of variceal hemorrhage".
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is recommended within 24 hours and bleeding can be stopped by various techniques.
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endoscopy is rapidly available, they are of less immediate clinical importance.
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with a clean base, which is a common cause of upper gastrointestinal hemorrhage.
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British Society of Gastroenterology Endoscopy Committee (October 2002).
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The causes for upper gastrointestinal hemorrhage include the following:
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is preferred in people with cirrhosis. Medications typically includes
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in those with upper gastrointestinal bleeding are not well known.
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A number of medications increase the risk of bleeding including
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in order to determine if the bleeding is from a variceal source.
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examination, in order to determine possible causes of hemorrhage
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Persons with upper gastrointestinal bleeding often present with
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If large amounts of pack red blood cells are used additional
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to reduce portal pressures. This is typically in addition to
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Hemoglobin level >12.9 g/dL (men) or >11.9 g/dL (women)
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Significant upper gastrointestinal bleeding is considered a
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Based on evidence from people with other health problems
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Score is equal to "0" if the following are all present:
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Bleeding of the esophagus, stomach, or upper intestine
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Gluud, LL; Klingenberg, SL, Langholz, SE (May 2008).
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Determining whether blood is in the gastric aspirate
152:. The initial assessment includes measurement of the 2066: 346:
double the rate of upper gastrointestinal bleeding.
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with overlying clot. Pathology was consistent with
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Gastrointestinal Endoscopy Clinics of North America
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Gastrointestinal Endoscopy Clinics of North America
1410: 956: 659:less than 2 may not require admission to hospital. 1544: 1502: 628:No past or present liver disease or heart failure 352:People are usually stratified into having either 136:Upper gastrointestinal bleeding can be caused by 3479: 1826: 109:, commonly defined as bleeding arising from the 33:Upper gastrointestinal hemorrhage, gastrorrhagia 1860: 1858: 1656: 1498: 1496: 1494: 1492: 1490: 1829:Critical Care Nursing Clinics of North America 1488: 1486: 1484: 1482: 1480: 1478: 1476: 1474: 1472: 1470: 780:The above ulcer seen after endoscopic clipping 453:Hematobilia, or bleeding from the biliary tree 2193: 738:transjugular intrahepatic portosystemic shunt 622:Blood urea nitrogen level <18.2 mg/dL 2299:Esophagogastric junction outflow obstruction 2036:: CS1 maint: multiple names: authors list ( 1855: 1803:: CS1 maint: multiple names: authors list ( 1369:: CS1 maint: multiple names: authors list ( 1278:: CS1 maint: multiple names: authors list ( 1226:: CS1 maint: multiple names: authors list ( 1171:: CS1 maint: multiple names: authors list ( 1114:: CS1 maint: multiple names: authors list ( 720:for the varices. If this is sufficient then 1957: 1704:The Cochrane Database of Systematic Reviews 1657:Serpico, M; Riscinti, M (6 December 2019). 1551:The Cochrane Database of Systematic Reviews 1467: 1239: 1237: 1122: 1073: 921: 2338:Esophageal intramural pseudodiverticulosis 2200: 2186: 1951: 1761:Alimentary Pharmacology & Therapeutics 1652: 1650: 1295: 1293: 1291: 1289: 1037: 696:For initial fluid replacement colloids or 616:Systolic blood pressure >109 mm Hg 38: 1934: 1882: 1772: 1731: 1674: 1630: 1620: 1578: 1186: 1184: 1182: 991: 939: 917: 915: 913: 893: 883: 1822: 1820: 1818: 1816: 1814: 1595: 1234: 1082:Cardiovascular Surgery (London, England) 775: 478: 313: 195:may also be useful. Procedures (such as 1915:Cochrane Database of Systematic Reviews 1647: 1447: 1286: 632: 88:(maroon-coloured stool) in severe cases 3480: 1179: 910: 858: 818:About 75% of people presenting to the 262:concentrates on the following things: 3322: 2566:Small intestinal bacterial overgrowth 2181: 1904: 1902: 1811: 1540: 1538: 1536: 1534: 494: 210: 47:Endoscopic image of a posterior wall 922:Beyda, R; Johari, D (22 July 2019). 691: 1455:"Glasgow-Blatchford bleeding score" 467:superior mesenteric artery syndrome 13: 1899: 1531: 756:should be administered to prevent 14: 3509: 3451:Spontaneous bacterial peritonitis 3298:Exocrine pancreatic insufficiency 2048: 2016:10.1016/j.annemergmed.2003.09.002 743: 504:(vomiting of blood) is observed. 288:stigmata of chronic liver disease 3493:Gastrointestinal tract disorders 3196:Secondary sclerosing cholangitis 1774:10.1111/j.1365-2036.2008.03638.x 1349:10.1097/00004836-198404000-00004 662: 2437:Gastric antral vascular ectasia 2432:Portal hypertensive gastropathy 2309:Gastroesophageal reflux disease 1994: 1871:New England Journal of Medicine 1748: 1691: 1404: 1377: 1328: 836:Lower gastrointestinal bleeding 813: 421:Gastric antral vascular ectasia 95:Upper gastrointestinal bleeding 25:Upper gastrointestinal bleeding 3191:Primary sclerosing cholangitis 3041:Hepatic veno-occlusive disease 2863:Solitary rectal ulcer syndrome 1927:10.1002/14651858.CD013176.pub2 1716:10.1002/14651858.CD006640.pub3 1563:10.1002/14651858.CD005415.pub4 1008: 1: 3248:Sphincter of Oddi dysfunction 1425:10.1016/S0140-6736(08)61769-9 1302:Archives of Internal Medicine 1258:10.1016/S0735-6757(99)90021-9 1094:10.1016/S0967-2109(03)00004-8 851: 792:to empty the stomach such as 771: 3157:Postcholecystectomy syndrome 2676:Intestinal pseudoobstruction 2284:Esophageal motility disorder 1137:(7): 583–7, discussion 587. 804: 641: 599:A scoring system called the 474: 294:Laboratory findings include 107:upper gastrointestinal tract 7: 1841:10.1016/j.ccell.2010.02.004 1663:Academic Emergency Medicine 1609:Annals of Internal Medicine 1314:10.1001/archinte.150.7.1381 928:Academic Emergency Medicine 872:Annals of Internal Medicine 829: 148:, and rarer causes such as 121:. Blood may be observed in 10: 3514: 3142:Gallstone / Cholelithiasis 2666:Functional colonic disease 2462:Zollinger–Ellison syndrome 1972:10.1016/j.giec.2018.02.001 1517:10.1016/j.giec.2011.07.001 1206:10.1016/j.ajem.2005.11.005 1143:10.1177/000313480407000704 984:10.1136/gut.51.suppl_4.iv1 3436: 3315: 3256: 3170: 3127: 2973: 2964: 2917: 2871: 2826: 2712: 2599: 2489: 2476: 2351: 2343:Acute esophageal necrosis 2225: 2216: 2140: 2070: 730:Sengstaken-Blakemore tube 549:Negative predictive value 544:Positive predictive value 513:negative predictive value 309: 103:gastrointestinal bleeding 67: 55: 46: 37: 29: 24: 2442:Gastric dumping syndrome 2317:Laryngopharyngeal reflux 2304:Diffuse esophageal spasm 768:may decrease mortality. 657:Glasgow Blatchford score 646:The initial focus is on 366:causes (gastrorrhagia): 3058:Alcoholic liver disease 2591:Bile acid malabsorption 2535:Peptic (duodenal) ulcer 459:, or bleeding from the 457:Hemosuccus pancreaticus 304:BUN-to-creatinine ratio 3068:Hepatic encephalopathy 2452:Buried bumper syndrome 2383:Peptic (gastric) ulcer 2267:Mallory–Weiss syndrome 2210:human digestive system 1337:J. Clin. Gastroenterol 841:Forrest classification 781: 491: 448:aorto-enteric fistulae 331: 221:coffee ground vomiting 189:Proton pump inhibitors 125:or in altered form as 78:coffee ground vomiting 3293:Pancreatic pseudocyst 3162:Porcelain gallbladder 2274:Zenker's diverticulum 1884:10.1056/NEJMoa1211801 1059:10.1056/NEJMcps062601 779: 652:Proton pump inhibitor 573:Physician assessment 482: 444:Vascular malformation 317: 3097:Hepatorenal syndrome 3036:Budd–Chiari syndrome 2993:Autoimmune hepatitis 2818:Intestinal adhesions 2576:Short bowel syndrome 2405:Functional dyspepsia 2323:Esophageal stricture 2289:Nutcracker esophagus 1131:The American Surgeon 1020:Global Family Doctor 820:emergency department 704:or if not available 633:Bayesian calculation 625:No melena or syncope 619:Pulse <100/minute 551:(prevalence of 39%) 509:nasogastric aspirate 256:physical examination 3498:Medical emergencies 3236:Choledocholithiasis 3107:Metabolic disorders 3073:Acute liver failure 3046:Portal hypertension 2998:Alcoholic hepatitis 2841:Radiation proctitis 2760:Mesenteric ischemia 2732:Gastroenterocolitis 2561:Blind loop syndrome 2371:MĂ©nĂ©trier's disease 2279:Barrett's esophagus 766:prothrombin complex 754:fresh frozen plasma 546:(prevalence of 39%) 531: 490:with visible vessel 426:Dieulafoy's lesions 284:portal hypertension 249:shortness of breath 183:, may be required. 3411:Undefined location 3402:Grynfeltt–Lesshaft 3303:Pancreatic fistula 3286:Pancreatic abscess 3241:Biliary dyskinesia 3212:Mirizzi's syndrome 2713:Large and/or small 2393:Dieulafoy's lesion 2262:Boerhaave syndrome 2141:External resources 2060:2021-08-27 at the 1676:10.1111/acem.13899 978:(Suppl 4): iv1–6. 941:10.1111/acem.13835 782: 714:endoscopic banding 601:Glasgow-Blatchford 529: 517:ligament of Treitz 495:Diagnostic testing 492: 388:Mallory-Weiss tear 370:Esophageal varices 332: 302:, and an elevated 211:Signs and symptoms 146:esophageal varices 76:(vomiting blood), 3475: 3474: 3471: 3470: 3311: 3310: 2913: 2912: 2770:Bowel obstruction 2472: 2471: 2175: 2174: 934:(10): 1181–1182. 790:Prokinetic agents 692:Variceal bleeding 596:control samples. 589: 588: 384:Esophageal ulcers 380:Esophageal cancer 318:Gastric ulcer in 258:performed by the 181:blood transfusion 177:Fluid replacement 173:medical emergency 164:to determine the 92: 91: 19:Medical condition 3505: 3463:Pneumoperitoneum 3320: 3319: 3230:Common bile duct 3112:Wilson's disease 3102:Peliosis hepatis 2971: 2970: 2848:Proctalgia fugax 2755:Abdominal angina 2680:Ogilvie syndrome 2629:Pseudomembranous 2487: 2486: 2447:Gastric volvulus 2412:Pyloric stenosis 2223: 2222: 2208:Diseases of the 2202: 2195: 2188: 2179: 2178: 2068: 2067: 2042: 2041: 2035: 2027: 1998: 1992: 1991: 1955: 1949: 1948: 1938: 1906: 1897: 1896: 1886: 1862: 1853: 1852: 1824: 1809: 1808: 1802: 1794: 1776: 1752: 1746: 1745: 1735: 1710:(11): CD006640. 1695: 1689: 1688: 1678: 1654: 1645: 1644: 1634: 1624: 1622:10.7326/M19-1795 1599: 1593: 1592: 1582: 1542: 1529: 1528: 1500: 1465: 1464: 1462: 1461: 1451: 1445: 1444: 1408: 1402: 1401: 1381: 1375: 1374: 1368: 1360: 1332: 1326: 1325: 1297: 1284: 1283: 1277: 1269: 1241: 1232: 1231: 1225: 1217: 1188: 1177: 1176: 1170: 1162: 1126: 1120: 1119: 1113: 1105: 1077: 1071: 1070: 1041: 1035: 1034: 1032: 1031: 1022:. Archived from 1012: 1006: 1005: 995: 963: 954: 953: 943: 919: 908: 907: 897: 887: 885:10.7326/M19-1795 862: 786:nasogastric tube 532: 528: 328:gastric lymphoma 191:are often used. 142:gastric erosions 62:Gastroenterology 42: 22: 21: 3513: 3512: 3508: 3507: 3506: 3504: 3503: 3502: 3478: 3477: 3476: 3467: 3432: 3421:Internal hernia 3307: 3252: 3217:Biliary fistula 3175: 3166: 3152:Adenomyomatosis 3147:Cholesterolosis 3123: 3117:Hemochromatosis 2988:Viral hepatitis 2960: 2909: 2867: 2853:Rectal prolapse 2822: 2789:Fecal impaction 2779:Intussusception 2742:Crohn's disease 2708: 2691:Toxic megacolon 2603: 2601:Large intestine 2595: 2540:Curling's ulcer 2493: 2491:Small intestine 2480: 2468: 2376:Gastroenteritis 2347: 2212: 2206: 2176: 2171: 2170: 2136: 2135: 2079: 2062:Wayback Machine 2051: 2046: 2045: 2029: 2028: 1999: 1995: 1956: 1952: 1921:(2): CD013176. 1907: 1900: 1863: 1856: 1825: 1812: 1796: 1795: 1753: 1749: 1696: 1692: 1655: 1648: 1615:(11): 805–822. 1600: 1596: 1557:(1): CD005415. 1543: 1532: 1501: 1468: 1459: 1457: 1453: 1452: 1448: 1409: 1405: 1382: 1378: 1362: 1361: 1333: 1329: 1298: 1287: 1271: 1270: 1242: 1235: 1219: 1218: 1189: 1180: 1164: 1163: 1127: 1123: 1107: 1106: 1078: 1074: 1053:(10): 1029–34. 1042: 1038: 1029: 1027: 1014: 1013: 1009: 964: 957: 920: 911: 878:(11): 805–822. 863: 859: 854: 832: 816: 807: 774: 746: 694: 678:Tranexamic acid 665: 644: 635: 550: 545: 497: 486:image of small 477: 461:pancreatic duct 416:Gastric varices 312: 282:Assessment for 213: 193:Tranexamic acid 20: 17: 12: 11: 5: 3511: 3501: 3500: 3495: 3490: 3473: 3472: 3469: 3468: 3466: 3465: 3460: 3458:Hemoperitoneum 3455: 3454: 3453: 3442: 3440: 3434: 3433: 3431: 3430: 3429: 3428: 3423: 3418: 3407: 3406: 3405: 3404: 3399: 3386: 3385: 3380: 3375: 3370: 3365: 3364: 3363: 3358: 3347: 3346: 3341: 3340: 3339: 3328: 3326: 3317: 3313: 3312: 3309: 3308: 3306: 3305: 3300: 3295: 3290: 3289: 3288: 3283: 3278: 3273: 3262: 3260: 3254: 3253: 3251: 3250: 3245: 3244: 3243: 3238: 3225: 3224: 3219: 3214: 3205: 3204: 3203: 3198: 3193: 3182: 3180: 3168: 3167: 3165: 3164: 3159: 3154: 3149: 3144: 3139: 3133: 3131: 3125: 3124: 3122: 3121: 3120: 3119: 3114: 3104: 3099: 3094: 3093: 3092: 3087: 3077: 3076: 3075: 3070: 3060: 3055: 3054: 3053: 3048: 3043: 3038: 3026: 3025: 3024: 3014: 3013: 3012: 3002: 3001: 3000: 2995: 2990: 2979: 2977: 2968: 2962: 2961: 2959: 2958: 2957: 2956: 2946: 2945: 2944: 2939: 2929: 2927:Blood in stool 2923: 2921: 2915: 2914: 2911: 2910: 2908: 2907: 2902: 2900:Anal dysplasia 2897: 2892: 2887: 2877: 2875: 2869: 2868: 2866: 2865: 2860: 2855: 2850: 2845: 2844: 2843: 2832: 2830: 2824: 2823: 2821: 2820: 2815: 2814: 2813: 2803: 2802: 2801: 2791: 2786: 2781: 2776: 2767: 2765:Angiodysplasia 2762: 2757: 2746: 2745: 2744: 2734: 2729: 2728: 2727: 2716: 2714: 2710: 2709: 2707: 2706: 2700:Diverticulosis 2696:Diverticulitis 2693: 2684: 2683: 2682: 2673: 2663: 2658: 2657: 2656: 2651: 2646: 2641: 2636: 2631: 2621: 2615: 2613: 2597: 2596: 2594: 2593: 2588: 2586:Milroy disease 2583: 2578: 2573: 2568: 2563: 2558: 2556:Tropical sprue 2553: 2544: 2543: 2542: 2532: 2531: 2530: 2525: 2520: 2509: 2507: 2484: 2478:Lower GI tract 2474: 2473: 2470: 2469: 2467: 2466: 2465: 2464: 2454: 2449: 2444: 2439: 2434: 2429: 2424: 2419: 2414: 2409: 2408: 2407: 2397: 2396: 2395: 2390: 2380: 2379: 2378: 2373: 2368: 2357: 2355: 2349: 2348: 2346: 2345: 2340: 2335: 2330: 2325: 2320: 2314: 2313: 2312: 2306: 2301: 2296: 2291: 2281: 2276: 2271: 2270: 2269: 2264: 2254: 2253: 2252: 2247: 2242: 2231: 2229: 2220: 2218:Upper GI tract 2214: 2213: 2205: 2204: 2197: 2190: 2182: 2173: 2172: 2169: 2168: 2157: 2145: 2144: 2142: 2138: 2137: 2134: 2133: 2122: 2111: 2096: 2080: 2075: 2074: 2072: 2071:Classification 2065: 2064: 2050: 2049:External links 2047: 2044: 2043: 1993: 1966:(3): 261–275. 1950: 1898: 1854: 1810: 1747: 1690: 1669:(4): 336–338. 1646: 1594: 1530: 1466: 1446: 1419:(9657): 42–7. 1403: 1376: 1327: 1285: 1246:Am J Emerg Med 1233: 1194:Am J Emerg Med 1178: 1121: 1072: 1036: 1007: 955: 909: 856: 855: 853: 850: 849: 848: 843: 838: 831: 828: 815: 812: 806: 803: 773: 770: 758:coagulopathies 745: 744:Blood products 742: 734:Minnesota tube 693: 690: 664: 661: 643: 640: 634: 631: 630: 629: 626: 623: 620: 617: 614: 587: 586: 583: 580: 577: 574: 570: 569: 566: 563: 560: 557: 553: 552: 547: 542: 539: 536: 496: 493: 476: 473: 472: 471: 470: 469: 463: 454: 451: 441: 439:Duodenal ulcer 430: 429: 428: 423: 418: 413: 408: 406:Gastric cancer 403: 392: 391: 390: 385: 382: 377: 372: 311: 308: 292: 291: 280: 270: 212: 209: 154:blood pressure 150:gastric cancer 90: 89: 71: 65: 64: 59: 53: 52: 49:duodenal ulcer 44: 43: 35: 34: 31: 27: 26: 18: 15: 9: 6: 4: 3: 2: 3510: 3499: 3496: 3494: 3491: 3489: 3486: 3485: 3483: 3464: 3461: 3459: 3456: 3452: 3449: 3448: 3447: 3444: 3443: 3441: 3439: 3435: 3427: 3424: 3422: 3419: 3417: 3414: 3413: 3412: 3409: 3408: 3403: 3400: 3398: 3395: 3394: 3393: 3392: 3388: 3387: 3384: 3381: 3379: 3376: 3374: 3371: 3369: 3366: 3362: 3359: 3357: 3354: 3353: 3352: 3349: 3348: 3345: 3342: 3338: 3335: 3334: 3333: 3332:Diaphragmatic 3330: 3329: 3327: 3325: 3321: 3318: 3314: 3304: 3301: 3299: 3296: 3294: 3291: 3287: 3284: 3282: 3279: 3277: 3274: 3272: 3269: 3268: 3267: 3264: 3263: 3261: 3259: 3255: 3249: 3246: 3242: 3239: 3237: 3234: 3233: 3232: 3231: 3227: 3226: 3223: 3220: 3218: 3215: 3213: 3209: 3206: 3202: 3199: 3197: 3194: 3192: 3189: 3188: 3187: 3184: 3183: 3181: 3179: 3173: 3169: 3163: 3160: 3158: 3155: 3153: 3150: 3148: 3145: 3143: 3140: 3138: 3137:Cholecystitis 3135: 3134: 3132: 3130: 3126: 3118: 3115: 3113: 3110: 3109: 3108: 3105: 3103: 3100: 3098: 3095: 3091: 3088: 3086: 3083: 3082: 3081: 3080:Liver abscess 3078: 3074: 3071: 3069: 3066: 3065: 3064: 3063:Liver failure 3061: 3059: 3056: 3052: 3049: 3047: 3044: 3042: 3039: 3037: 3034: 3033: 3032: 3031: 3027: 3023: 3020: 3019: 3018: 3015: 3011: 3008: 3007: 3006: 3003: 2999: 2996: 2994: 2991: 2989: 2986: 2985: 2984: 2981: 2980: 2978: 2976: 2972: 2969: 2967: 2963: 2955: 2952: 2951: 2950: 2947: 2943: 2940: 2938: 2935: 2934: 2933: 2930: 2928: 2925: 2924: 2922: 2920: 2916: 2906: 2903: 2901: 2898: 2896: 2893: 2891: 2888: 2886: 2882: 2879: 2878: 2876: 2874: 2870: 2864: 2861: 2859: 2856: 2854: 2851: 2849: 2846: 2842: 2839: 2838: 2837: 2834: 2833: 2831: 2829: 2825: 2819: 2816: 2812: 2809: 2808: 2807: 2804: 2800: 2797: 2796: 2795: 2792: 2790: 2787: 2785: 2782: 2780: 2777: 2775: 2771: 2768: 2766: 2763: 2761: 2758: 2756: 2752: 2751: 2747: 2743: 2740: 2739: 2738: 2735: 2733: 2730: 2726: 2723: 2722: 2721: 2720:Enterocolitis 2718: 2717: 2715: 2711: 2705: 2701: 2697: 2694: 2692: 2688: 2685: 2681: 2677: 2674: 2672: 2669: 2668: 2667: 2664: 2662: 2659: 2655: 2652: 2650: 2647: 2645: 2642: 2640: 2637: 2635: 2632: 2630: 2627: 2626: 2625: 2622: 2620: 2617: 2616: 2614: 2611: 2607: 2602: 2598: 2592: 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2567: 2564: 2562: 2559: 2557: 2554: 2552: 2548: 2547:Malabsorption 2545: 2541: 2538: 2537: 2536: 2533: 2529: 2526: 2524: 2521: 2519: 2516: 2515: 2514: 2511: 2510: 2508: 2505: 2501: 2497: 2492: 2488: 2485: 2483: 2479: 2475: 2463: 2460: 2459: 2458: 2455: 2453: 2450: 2448: 2445: 2443: 2440: 2438: 2435: 2433: 2430: 2428: 2425: 2423: 2422:Gastroparesis 2420: 2418: 2415: 2413: 2410: 2406: 2403: 2402: 2401: 2398: 2394: 2391: 2389: 2388:Cushing ulcer 2386: 2385: 2384: 2381: 2377: 2374: 2372: 2369: 2367: 2364: 2363: 2362: 2359: 2358: 2356: 2354: 2350: 2344: 2341: 2339: 2336: 2334: 2333:Megaesophagus 2331: 2329: 2326: 2324: 2321: 2318: 2315: 2310: 2307: 2305: 2302: 2300: 2297: 2295: 2292: 2290: 2287: 2286: 2285: 2282: 2280: 2277: 2275: 2272: 2268: 2265: 2263: 2260: 2259: 2258: 2255: 2251: 2248: 2246: 2243: 2241: 2238: 2237: 2236: 2233: 2232: 2230: 2228: 2224: 2221: 2219: 2215: 2211: 2203: 2198: 2196: 2191: 2189: 2184: 2183: 2180: 2167: 2163: 2162: 2158: 2156: 2152: 2151: 2147: 2146: 2143: 2139: 2132: 2128: 2127: 2123: 2121: 2117: 2116: 2112: 2110: 2106: 2105: 2101: 2097: 2095: 2091: 2090: 2086: 2082: 2081: 2078: 2073: 2069: 2063: 2059: 2056: 2053: 2052: 2039: 2033: 2025: 2021: 2017: 2013: 2010:(4): 525–32. 2009: 2005: 2004:Ann Emerg Med 1997: 1989: 1985: 1981: 1977: 1973: 1969: 1965: 1961: 1954: 1946: 1942: 1937: 1932: 1928: 1924: 1920: 1916: 1912: 1905: 1903: 1894: 1890: 1885: 1880: 1876: 1872: 1868: 1861: 1859: 1850: 1846: 1842: 1838: 1835:(3): 381–93. 1834: 1830: 1823: 1821: 1819: 1817: 1815: 1806: 1800: 1792: 1788: 1784: 1780: 1775: 1770: 1766: 1762: 1758: 1751: 1743: 1739: 1734: 1729: 1725: 1721: 1717: 1713: 1709: 1705: 1701: 1694: 1686: 1682: 1677: 1672: 1668: 1664: 1660: 1653: 1651: 1642: 1638: 1633: 1628: 1623: 1618: 1614: 1610: 1606: 1598: 1590: 1586: 1581: 1576: 1572: 1568: 1564: 1560: 1556: 1552: 1548: 1541: 1539: 1537: 1535: 1526: 1522: 1518: 1514: 1511:(4): 657–70. 1510: 1506: 1499: 1497: 1495: 1493: 1491: 1489: 1487: 1485: 1483: 1481: 1479: 1477: 1475: 1473: 1471: 1456: 1450: 1442: 1438: 1434: 1430: 1426: 1422: 1418: 1414: 1407: 1399: 1395: 1391: 1387: 1380: 1372: 1366: 1358: 1354: 1350: 1346: 1343:(2): 119–21. 1342: 1338: 1331: 1323: 1319: 1315: 1311: 1308:(7): 1381–4. 1307: 1303: 1296: 1294: 1292: 1290: 1281: 1275: 1267: 1263: 1259: 1255: 1251: 1247: 1240: 1238: 1229: 1223: 1215: 1211: 1207: 1203: 1199: 1195: 1187: 1185: 1183: 1174: 1168: 1160: 1156: 1152: 1148: 1144: 1140: 1136: 1132: 1125: 1117: 1111: 1103: 1099: 1095: 1091: 1087: 1083: 1076: 1068: 1064: 1060: 1056: 1052: 1048: 1040: 1026:on 2011-07-11 1025: 1021: 1017: 1011: 1003: 999: 994: 989: 985: 981: 977: 973: 969: 962: 960: 951: 947: 942: 937: 933: 929: 925: 918: 916: 914: 905: 901: 896: 891: 886: 881: 877: 873: 869: 861: 857: 847: 846:Rockall score 844: 842: 839: 837: 834: 833: 827: 825: 821: 811: 802: 800: 795: 791: 787: 778: 769: 767: 763: 759: 755: 751: 741: 739: 735: 731: 727: 723: 722:beta blockers 719: 718:sclerotherapy 715: 711: 710:nitroglycerin 707: 703: 699: 689: 687: 683: 679: 674: 670: 663:Peptic ulcers 660: 658: 653: 649: 648:resuscitation 639: 627: 624: 621: 618: 615: 612: 611: 610: 609: 605: 602: 597: 595: 584: 581: 578: 575: 572: 571: 567: 564: 561: 558: 555: 554: 548: 543: 540: 537: 534: 533: 527: 525: 524:orthotolidine 520: 518: 514: 510: 505: 503: 489: 488:gastric ulcer 485: 481: 468: 464: 462: 458: 455: 452: 449: 445: 442: 440: 437: 436: 434: 431: 427: 424: 422: 419: 417: 414: 412: 409: 407: 404: 402: 401:Gastric ulcer 399: 398: 396: 393: 389: 386: 383: 381: 378: 376: 373: 371: 368: 367: 365: 362: 361: 360: 357: 355: 350: 347: 345: 341: 337: 329: 325: 321: 316: 307: 305: 301: 297: 289: 285: 281: 278: 274: 271: 268: 265: 264: 263: 261: 257: 252: 250: 246: 242: 238: 234: 230: 226: 222: 218: 208: 204: 202: 198: 194: 190: 186: 182: 179:, as well as 178: 174: 169: 167: 163: 160:, as well as 159: 155: 151: 147: 143: 139: 138:peptic ulcers 134: 132: 128: 124: 120: 116: 112: 108: 104: 100: 96: 87: 83: 79: 75: 72: 70: 66: 63: 60: 58: 54: 50: 45: 41: 36: 32: 28: 23: 3410: 3389: 3266:Pancreatitis 3228: 3178:biliary tree 3051:Nutmeg liver 3028: 2954:Hematochezia 2931: 2905:Pruritus ani 2890:Anal abscess 2885:Anal fistula 2881:Anal fissure 2794:Constipation 2748: 2619:Appendicitis 2427:Gastroptosis 2417:Achlorhydria 2256: 2245:Eosinophilic 2159: 2148: 2124: 2113: 2098: 2083: 2032:cite journal 2007: 2003: 1996: 1963: 1959: 1953: 1918: 1914: 1877:(1): 11–21. 1874: 1870: 1832: 1828: 1799:cite journal 1767:(9): 752–8. 1764: 1760: 1750: 1707: 1703: 1693: 1666: 1662: 1612: 1608: 1597: 1554: 1550: 1508: 1504: 1458:. Retrieved 1449: 1416: 1412: 1406: 1392:(7): 625–7. 1389: 1385: 1379: 1365:cite journal 1340: 1336: 1330: 1305: 1301: 1274:cite journal 1249: 1245: 1222:cite journal 1200:(3): 280–5. 1197: 1193: 1167:cite journal 1134: 1130: 1124: 1110:cite journal 1088:(3): 185–8. 1085: 1081: 1075: 1050: 1047:N Engl J Med 1046: 1039: 1028:. Retrieved 1024:the original 1019: 1010: 975: 971: 931: 927: 875: 871: 860: 817: 814:Epidemiology 808: 794:erythromycin 783: 747: 695: 682:Somatostatin 666: 645: 636: 607: 606: 598: 593: 590: 556:Gastroccult 521: 506: 498: 446:, including 358: 351: 348: 333: 300:coagulopathy 293: 253: 235:, including 229:hematochezia 214: 205: 170: 135: 98: 94: 93: 86:hematochezia 3446:Peritonitis 3208:Cholestasis 3186:Cholangitis 3129:Gallbladder 3017:Fatty liver 2937:Hematemesis 2919:GI bleeding 2725:Necrotizing 2654:Lymphocytic 2649:Collagenous 2644:Microscopic 2581:Steatorrhea 2482:Enteropathy 2328:Inlet patch 2250:Herpetiform 2235:Esophagitis 2150:MedlinePlus 1252:(1): 70–2. 824:hematemesis 706:vasopressin 669:crystalloid 541:Specificity 538:Sensitivity 502:hematemesis 375:Esophagitis 267:Vital signs 217:hematemesis 162:blood tests 127:black stool 74:Hematemesis 30:Other names 3482:Categories 3438:Peritoneal 3416:Incisional 3337:Congenital 3281:Hereditary 3258:Pancreatic 3222:Haemobilia 2895:Hemorrhoid 2873:Anal canal 2811:Infectious 2799:Functional 2634:Ulcerative 2518:Duodenitis 2457:Gastrinoma 2126:DiseasesDB 2055:Patient.uk 1460:2009-01-24 1386:Clin Pharm 1030:2010-11-24 852:References 799:Parenteral 772:Procedures 762:hemoglobin 702:octreotide 686:octreotide 484:Endoscopic 364:Esophageal 237:chest pain 166:hemoglobin 158:heart rate 3426:Richter's 3383:Spigelian 3378:Obturator 3368:Umbilical 3201:Ascending 3172:Bile duct 3005:Cirrhosis 2983:Hepatitis 2966:Accessory 2836:Proctitis 2687:Megacolon 2661:Dysentery 2571:Whipple's 2523:Jejunitis 2513:Enteritis 2400:Dyspepsia 2361:Gastritis 2294:Achalasia 2227:Esophagus 2161:eMedicine 1724:1469-493X 1571:1469-493X 805:Prognosis 750:platelets 642:Treatment 475:Diagnosis 411:Gastritis 273:Abdominal 260:physician 185:Endoscopy 111:esophagus 57:Specialty 3488:Bleeding 3356:Indirect 3351:Inguinal 3085:Pyogenic 3030:Vascular 2806:Diarrhea 2784:Volvulus 2750:Vascular 2689: / 2678: / 2639:Ischemic 2606:Appendix 2496:Duodenum 2366:Atrophic 2240:Candidal 2166:med/3565 2058:Archived 2024:15039700 1988:49377957 1980:29933774 1945:36723439 1893:23281973 1849:20691388 1791:24594884 1783:18248659 1742:25414987 1685:31808973 1641:31634917 1589:34995368 1525:21944416 1433:19091393 1214:16635697 1159:29517032 1151:15279179 1102:12704326 1067:17804848 1002:12208839 950:31329328 904:31634917 830:See also 726:nitrates 673:colloids 435:causes: 433:Duodenal 397:causes: 354:variceal 119:duodenum 69:Symptoms 3397:Petit's 3373:Femoral 3276:Chronic 3090:Amoebic 2858:Anismus 2624:Colitis 2551:Coeliac 2528:Ileitis 2500:Jejunum 2353:Stomach 2257:Rupture 2120:D006471 1936:9891197 1733:6599825 1632:7233308 1580:8741303 1441:1738579 1398:1617913 1357:6715849 1322:2196022 1266:9928705 993:1867732 895:7233308 698:albumin 535:Finding 465:Severe 395:Gastric 324:stomach 245:fatigue 241:syncope 201:surgery 115:stomach 105:in the 3391:Lumbar 3361:Direct 3344:Hiatus 3324:Hernia 3176:Other 2942:Melena 2828:Rectum 2311:(GERD) 2155:003133 2022:  1986:  1978:  1943:  1933:  1891:  1847:  1789:  1781:  1740:  1730:  1722:  1683:  1639:  1629:  1587:  1577:  1569:  1523:  1439:  1431:  1413:Lancet 1396:  1355:  1320:  1264:  1212:  1157:  1149:  1100:  1065:  1000:  990:  948:  902:  892:  336:NSAIDs 320:antrum 310:Causes 296:anemia 277:rectal 233:anemia 225:melena 82:melena 3316:Other 3271:Acute 3022:MASLD 2975:Liver 2949:Lower 2932:Upper 2774:Ileus 2610:Colon 2504:Ileum 2319:(LPR) 2131:19317 2109:578.9 2094:K92.2 1984:S2CID 1787:S2CID 1437:S2CID 1155:S2CID 344:SSRIs 340:SSRIs 227:, or 131:shock 123:vomit 117:, or 101:) is 2704:SCAD 2115:MeSH 2104:9-CM 2038:link 2020:PMID 1976:PMID 1941:PMID 1919:2023 1889:PMID 1845:PMID 1805:link 1779:PMID 1738:PMID 1720:ISSN 1708:2014 1681:PMID 1637:PMID 1585:PMID 1567:ISSN 1521:PMID 1429:PMID 1394:PMID 1371:link 1353:PMID 1318:PMID 1280:link 1262:PMID 1228:link 1210:PMID 1173:link 1147:PMID 1116:link 1098:PMID 1063:PMID 998:PMID 946:PMID 900:PMID 752:and 724:and 708:and 684:and 671:and 585:20% 568:96% 338:and 286:and 275:and 254:The 247:and 197:TIPS 156:and 99:UGIB 3010:PBC 2737:IBD 2671:IBS 2100:ICD 2085:ICD 2012:doi 1968:doi 1931:PMC 1923:doi 1879:doi 1875:368 1837:doi 1769:doi 1728:PMC 1712:doi 1671:doi 1627:PMC 1617:doi 1613:171 1575:PMC 1559:doi 1513:doi 1421:doi 1417:373 1345:doi 1310:doi 1306:150 1254:doi 1202:doi 1139:doi 1090:doi 1055:doi 1051:357 988:PMC 980:doi 972:Gut 936:doi 890:PMC 880:doi 876:171 732:or 716:or 594:all 582:53% 579:55% 576:79% 565:77% 562:82% 559:95% 322:of 3484:: 3174:/ 2772:: 2753:: 2549:: 2164:: 2153:: 2129:: 2118:: 2107:: 2092:: 2089:10 2034:}} 2030:{{ 2018:. 2008:43 2006:. 1982:. 1974:. 1964:28 1962:. 1939:. 1929:. 1917:. 1913:. 1901:^ 1887:. 1873:. 1869:. 1857:^ 1843:. 1833:22 1831:. 1813:^ 1801:}} 1797:{{ 1785:. 1777:. 1765:27 1763:. 1759:. 1736:. 1726:. 1718:. 1706:. 1702:. 1679:. 1667:27 1665:. 1661:. 1649:^ 1635:. 1625:. 1611:. 1607:. 1583:. 1573:. 1565:. 1553:. 1549:. 1533:^ 1519:. 1509:21 1507:. 1469:^ 1435:. 1427:. 1415:. 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Index


duodenal ulcer
Specialty
Gastroenterology
Symptoms
Hematemesis
coffee ground vomiting
melena
hematochezia
gastrointestinal bleeding
upper gastrointestinal tract
esophagus
stomach
duodenum
vomit
black stool
shock
peptic ulcers
gastric erosions
esophageal varices
gastric cancer
blood pressure
heart rate
blood tests
hemoglobin
medical emergency
Fluid replacement
blood transfusion
Endoscopy
Proton pump inhibitors

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