311:
288:
42:
615:/mL and the urine concentration was 13–210 ng/mL. Both the blood and the urine levels of tetryzoline reached their maximums approximately 9 hrs after the last dose. These fluid-concentration levels correspond to normal ocular use of tetryzoline; thus, greater concentrations of tetryzoline in the blood and the urine of the user can indicate misuse of the drug or of poisoning with the drug.
610:
of tetryzoline is approximately 6 hours, and it is excreted in urine, chemically unchanged, at least in part. In one study, 10 people were given two drops of 0.5 mg/mL of tetryzoline eye drops (0.025–0.05 mg) at 0 hrs, 4 hrs, 8 hrs, and 12 hrs. Within a 24-hour time
728:
664:
in an unsuspecting person's beverage. However, the actual results of the prank may be worse, varying from severe nausea and vomiting to seizures or a coma. Larger doses can cause death. Diarrhea is not a side effect.
504:. Tetryzoline is not suitable for prolonged use as its vasoconstrictive effects within the eye eventually decrease or stop. If tolerance to the drug has developed, ceasing its use may cause a rebound effect and
1040:
Carr ME, Engebretsen KM, Ho B, Anderson CP (November 2011). "Tetrahydrozoline (Visine®) concentrations in serum and urine during therapeutic ocular dosing: a necessary first step in determining an overdose".
706:
paramedic was accused of using tetryzoline eye drops to cause the death of his wife. The blood sample results showed about 30–40 times higher than the therapeutic level of tetryzoline.
677:
woman was charged with murdering her husband by putting eye drops containing tetryzoline in his drinking water. An autopsy found a high concentration of tetryzoline in his body.
1246:
1376:
952:"Unintentional pediatric ophthalmic tetrahydrozoline ingestion: case files of the medical toxicology fellowship at the University of California, San Francisco"
54:
788:
853:
1453:
456:
1334:
1270:"Wisconsin woman arrested, accused of murdering friend with eye drops: An investigation alleges the victim's water bottle was laced with Visine"
2318:
2298:
17:
1269:
3721:
3716:
1309:
1369:
412:
726:, Synerholm M, Jules LH, Sahyun M, "Imidazoline Derivatives", issued 17 January 1956, assigned to Sahyun Laboratories.
691:, died in an apparent overdose or suicide involving tetryzoline and other substances; in November 2023 her caregiver was convicted of
3026:
2353:
1606:
1288:
3684:
1222:
1362:
3666:
3657:
782:"International Non-Proprietary Names for Pharmaceutical Preparations. Recommended International Non-Proprietary Names: List 3"
611:
window, since the last dose of tetryzoline, the blood serum concentration of tetryzoline in the test subjects was 0.068-0.380
3648:
824:
754:
1109:
374:
3675:
1239:
749:(12th ed.). Whitehouse Station, NJ, United States: Chapman & Hall Electronic Publishing Division. p. 1453.
463:
477:
432:
692:
97:
3736:
3693:
781:
1110:"Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis"
2684:
845:
3639:
306:
187:
558:, drowsiness, headaches and vomiting may also occur. In serious cases some of these effects may result in
2518:
2068:
1808:
1396:
267:
660:
suggests that tetryzoline can cause violent diarrhea if given orally, such as by putting a few drops of
1973:
256:
723:
3741:
876:"Brimonidine Ophthalmic Solution 0.025% for Reduction of Ocular Redness: A Randomized Clinical Trial"
404:
Very soluble in water and ethanol, slightly soluble in chloroform and insoluble in diethylether
1991:
1293:
590:. This action relieves the redness of the eye caused by minor ocular irritants. Moreover, to treat
583:
283:
2639:
1310:"Paramedic accused of fatally poisoning his wife with ingredient found in eye drops: Prosecutors"
591:
2404:
2096:
2086:
1657:
1414:
624:
539:
440:
InChI=1S/C13H16N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,12H,3,5,7-9H2,(H,14,15)
814:
565:
There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the
236:
3726:
2603:
2379:
2022:
566:
1002:
Stillwell ME, Saady JJ (September 2012). "Use of tetrahydrozoline for chemical submission".
3262:
607:
196:
176:
8:
2941:
2807:
2283:
2189:
1586:
1492:
1385:
688:
555:
122:
1147:
310:
287:
131:
3731:
1388:
1066:
976:
951:
900:
875:
547:
543:
516:
511:
Intranasal use of tetryzoline may cause transient burning, stinging, or dryness of the
3372:
3347:
3267:
2145:
1895:
1760:
1152:
1058:
1019:
981:
905:
820:
760:
750:
559:
1196:
1070:
1015:
515:
and sneezing. Prolonged intranasal use often causes opposite effects in the form of
3342:
2906:
2749:
2548:
2126:
1888:
1878:
1439:
1142:
1132:
1128:
1124:
1050:
1011:
971:
963:
895:
887:
587:
399:
323:
77:
67:
695:, following the allegation that her death was caused by a water bottle laced with
2140:
1448:
1354:
1170:
1054:
891:
535:
156:
684:
in a number of cases due to its ability to cause dizziness and unconsciousness.
3252:
2921:
2886:
2607:
2363:
2273:
2026:
1891:
1611:
1566:
703:
681:
674:
501:
41:
967:
3710:
3402:
3242:
2926:
2870:
2827:
2488:
2412:
2278:
2217:
2106:
1995:
1907:
1661:
1581:
1576:
1520:
1507:
628:
391:
385:
299:
764:
33:
3427:
3412:
3357:
2852:
2674:
2619:
2611:
2583:
2543:
2462:
2428:
2243:
2038:
2030:
2011:
1999:
1883:
1752:
1728:
1688:
1156:
1108:
Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015).
1062:
1023:
985:
909:
657:
72:
62:
3552:
3527:
3522:
3517:
3407:
3382:
3367:
3352:
3317:
3302:
3282:
3277:
3247:
3227:
3202:
3187:
3132:
3077:
3006:
3001:
2996:
2956:
2951:
2857:
2842:
2812:
2802:
2787:
2758:
2729:
2573:
2563:
2538:
2528:
2493:
2436:
2399:
2328:
2303:
2268:
2204:
2179:
2169:
2150:
2111:
1981:
1858:
1853:
1813:
1788:
1778:
1768:
1738:
1733:
1708:
1683:
1677:
1642:
1601:
1561:
1546:
1541:
1487:
1477:
1458:
1419:
632:
551:
489:
390:
117–119 °C (243–246 °F) 256–257 °C (493–495 °F) for
1084:
923:
3617:
3607:
3597:
3582:
3577:
3562:
3542:
3537:
3512:
3507:
3492:
3472:
3467:
3462:
3432:
3422:
3417:
3387:
3377:
3337:
3327:
3307:
3257:
3237:
3217:
3212:
3192:
3177:
3172:
3162:
3142:
3137:
3127:
3122:
3117:
3097:
3082:
3072:
3052:
3031:
3016:
2991:
2986:
2981:
2966:
2961:
2946:
2931:
2916:
2911:
2901:
2891:
2847:
2832:
2822:
2797:
2792:
2773:
2763:
2744:
2739:
2719:
2714:
2704:
2699:
2689:
2679:
2669:
2659:
2654:
2598:
2588:
2578:
2568:
2508:
2498:
2478:
2473:
2458:
2432:
2424:
2420:
2394:
2389:
2338:
2333:
2313:
2308:
2263:
2253:
2248:
2238:
2199:
2184:
2174:
2135:
2121:
2017:
2007:
1968:
1963:
1953:
1948:
1938:
1923:
1899:
1873:
1863:
1848:
1843:
1833:
1828:
1798:
1783:
1756:
1718:
1704:
1700:
1696:
1673:
1669:
1632:
1591:
1571:
1551:
1536:
1502:
1482:
1434:
1429:
1240:"Wife admits fatally poisoning 'unfaithful' hubby with eye drops: cops"
595:
492:. Tetryzoline was patented in 1954, and came into medical use in 1959.
350:
167:
3612:
3602:
3587:
3567:
3557:
3532:
3502:
3482:
3477:
3457:
3452:
3447:
3397:
3392:
3362:
3332:
3322:
3287:
3272:
3232:
3222:
3207:
3197:
3182:
3157:
3152:
3147:
3112:
3107:
3087:
3057:
3021:
2976:
2971:
2936:
2896:
2837:
2817:
2778:
2724:
2709:
2694:
2664:
2625:
2593:
2558:
2553:
2523:
2468:
2450:
2446:
2416:
2408:
2348:
2288:
2258:
2233:
2194:
2160:
2116:
2054:
1985:
1977:
1958:
1943:
1933:
1928:
1913:
1903:
1868:
1838:
1823:
1818:
1803:
1793:
1772:
1743:
1723:
1712:
1665:
1652:
1647:
1637:
1627:
1556:
1497:
1468:
1424:
1137:
562:. Most often overdoses occur in children who have ingested the drug.
142:
3497:
3487:
3437:
3312:
3297:
3292:
3102:
3067:
3062:
3036:
3011:
2878:
2768:
2734:
2615:
2513:
2503:
2483:
2454:
2440:
2384:
2358:
2343:
2225:
2155:
2044:
2034:
1918:
1764:
1748:
1692:
1528:
1463:
612:
520:
500:
Tetryzoline eye drops may cause blurred vision, eye irritation and
485:
216:
373:
3592:
3572:
3547:
3442:
3167:
3092:
2533:
2101:
2049:
2003:
1335:"How Visine Eye Drops In The Mouth Can Kill, Here Are Two Cases"
745:
Budavari S, O'Neil M, Smith A, Heckelman P, Obenchain J (2000).
744:
2862:
2209:
2091:
1512:
1289:"Wisconsin woman found guilty of killing friend with eye drops"
722:
696:
661:
512:
247:
1197:"US wife accused of 'fatally poisoning husband with eyedrops'"
364:
227:
648:
272:
2293:
1107:
207:
1224:
Police: Woman kills husband by putting eye drops in water
1039:
874:
McLaurin E, Cavet ME, Gomes PJ, Ciolino JB (March 2018).
873:
523:. Prolonged use thus may result in overuse of the drug.
109:)-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1
519:with effects such as chronic redness, swelling and
1384:
594:, tetryzoline can be combined in a solution with
3708:
949:
155:
950:Al-Abri SA, Yang HS, Olson KR (December 2014).
812:
526:In children, it might cause profound sedation.
130:
1001:
508:redness of the eyes — a vasodilatory effect.
1370:
1307:
1117:The Cochrane Database of Systematic Reviews
1377:
1363:
1267:
787:. World Health Organization. p. 474.
484:, is a drug used in some over-the-counter
309:
286:
175:
40:
1146:
1136:
975:
899:
195:
1237:
1101:
776:
774:
282:
14:
3709:
1308:Jacobo J, Stein B (23 December 2019).
1286:
819:. John Wiley & Sons. p. 552.
806:
740:
738:
638:
300:
1358:
1035:
1033:
771:
255:
235:
3722:Alpha-2 adrenergic receptor agonists
3717:Alpha-1 adrenergic receptor agonists
997:
995:
945:
943:
840:
838:
836:
76:
66:
1332:
1227:, Associated Press, August 31, 2018
735:
601:
577:
215:
146:
24:
1030:
25:
3753:
992:
940:
833:
569:. With treatment, death is rare.
687:In 2018, a 62 year-old woman in
340:
334:
3685:Monoamine metabolism modulators
1326:
1301:
1280:
1261:
1249:from the original on 2018-09-02
1238:Connelly E (1 September 2018).
1231:
1215:
1189:
1171:"Visine Prank: Mickey Red Eyes"
1163:
1077:
1016:10.1016/j.forsciint.2012.04.004
856:from the original on 2017-01-03
813:Fischer J, Ganellin CR (2006).
794:from the original on 2016-09-11
680:Tetryzoline has been used as a
668:
651:
572:
495:
445:Key:BYJAVTDNIXVSPW-UHFFFAOYSA-N
1129:10.1002/14651858.CD009566.pub2
1004:Forensic Science International
916:
867:
716:
328:
18:Tetrahydrozoline hydrochloride
13:
1:
3667:Monoamine reuptake inhibitors
3640:Receptor/signaling modulators
1287:Deliso M (14 November 2023).
956:Journal of Medical Toxicology
816:Analogue-based Drug Discovery
709:
623:Chemically, tetryzoline is a
1268:Hutchinson B (8 June 2021).
1055:10.3109/15563650.2011.615064
892:10.1097/OPX.0000000000001182
880:Optometry and Vision Science
618:
7:
2750:Deoxyepinephrine (epinine,
2127:Deoxyepinephrine (epinine,
1974:Tetracyclic antidepressants
1440:Deoxyepinephrine (epinine,
534:Overdose most often causes
529:
420:N\1=C(\NCC/1)C3c2ccccc2CCC3
10:
3758:
3676:Monoamine releasing agents
1333:Lee BY (18 January 2020).
567:symptoms can be alleviated
318:Chemical and physical data
3630:
3045:
2647:
2638:
2372:
2079:
2067:
1992:Tricyclic antidepressants
1620:
1407:
1395:
968:10.1007/s13181-014-0400-9
606:In a healthy person, the
453:
428:
408:
398:
384:
362:
349:
322:
317:
298:
266:
246:
226:
206:
186:
166:
141:
121:
93:
88:
53:
48:
39:
643:
2405:Atypical antipsychotics
1658:Atypical antipsychotics
673:In late August 2018, a
592:allergic conjunctivitis
2604:Typical antipsychotics
2087:(R)-3-Nitrobiphenyline
2023:Typical antipsychotics
540:Respiratory depression
3737:Topical decongestants
3694:Monoamine neurotoxins
3263:Dichloroisoprenaline
608:biological half-life
554:, brief episodes of
2942:Phenylpropanolamine
2808:Ethylnorepinephrine
2284:Phenylpropanolamine
2190:Ethylnorepinephrine
1587:Phenylpropanolamine
1493:Ethylnorepinephrine
1386:Adrenergic receptor
1043:Clinical Toxicology
693:first-degree murder
689:Pewaukee, Wisconsin
639:Society and culture
556:high blood pressure
400:Solubility in water
36:
1203:. 4 September 2018
850:toxnet.nlm.nih.gov
846:"Tetrahydrozoline"
582:Tetryzoline is an
548:constricted pupils
544:low blood pressure
517:rebound congestion
32:
3704:
3703:
3697:
3688:
3679:
3670:
3661:
3652:
3643:
3626:
3625:
3373:Iodocyanopindolol
3348:Hydroxytertatolol
3268:Dihydroalprenolol
2881:
2873:
2865:
2782:
2634:
2633:
2228:
2220:
2212:
2164:
2146:Dihydroergotamine
2063:
2062:
1896:hydroxynefazodone
1761:dihydroergotamine
1531:
1523:
1515:
1472:
1245:. New York Post.
826:978-3-527-60749-5
756:978-1-58488-129-2
560:circulatory shock
480:), also known as
471:
470:
375:Interactive image
268:CompTox Dashboard
27:Chemical compound
16:(Redirected from
3749:
3742:Vasoconstrictors
3691:
3682:
3673:
3664:
3655:
3646:
3634:
3343:Hydroxycarteolol
2907:Methoxyphenamine
2879:
2871:
2866:-DOPA (levodopa)
2863:
2780:
2754:-methyldopamine)
2645:
2644:
2549:Phenoxybenzamine
2226:
2218:
2213:-DOPA (levodopa)
2210:
2162:
2131:-methyldopamine)
2077:
2076:
1889:Phenylpiperazine
1879:Phenoxybenzamine
1529:
1521:
1516:-DOPA (levodopa)
1513:
1470:
1454:Dexisometheptene
1444:-methyldopamine)
1405:
1404:
1379:
1372:
1365:
1356:
1355:
1349:
1348:
1346:
1345:
1330:
1324:
1323:
1321:
1320:
1305:
1299:
1298:
1284:
1278:
1277:
1265:
1259:
1258:
1256:
1254:
1244:
1235:
1229:
1228:
1219:
1213:
1212:
1210:
1208:
1193:
1187:
1186:
1184:
1182:
1167:
1161:
1160:
1150:
1140:
1114:
1105:
1099:
1098:
1096:
1095:
1081:
1075:
1074:
1037:
1028:
1027:
999:
990:
989:
979:
947:
938:
937:
935:
934:
920:
914:
913:
903:
871:
865:
864:
862:
861:
842:
831:
830:
810:
804:
803:
801:
799:
793:
786:
778:
769:
768:
742:
733:
732:
731:
727:
720:
602:Pharmacokinetics
588:alpha-1 receptor
578:Pharmacodynamics
482:tetrahydrozoline
467:
466:
459:
377:
357:
342:
336:
330:
313:
302:
291:
290:
276:
274:
259:
239:
219:
199:
179:
159:
149:
148:
134:
80:
70:
44:
37:
35:
31:
21:
3757:
3756:
3752:
3751:
3750:
3748:
3747:
3746:
3707:
3706:
3705:
3700:
3622:
3041:
2630:
2368:
2141:Dexmedetomidine
2072:
2059:
1892:antidepressants
1616:
1449:Desglymidodrine
1400:
1391:
1383:
1353:
1352:
1343:
1341:
1331:
1327:
1318:
1316:
1306:
1302:
1285:
1281:
1266:
1262:
1252:
1250:
1242:
1236:
1232:
1221:
1220:
1216:
1206:
1204:
1195:
1194:
1190:
1180:
1178:
1169:
1168:
1164:
1123:(6): CD009566.
1112:
1106:
1102:
1093:
1091:
1089:go.drugbank.com
1083:
1082:
1078:
1038:
1031:
1000:
993:
948:
941:
932:
930:
928:go.drugbank.com
922:
921:
917:
872:
868:
859:
857:
844:
843:
834:
827:
811:
807:
797:
795:
791:
784:
780:
779:
772:
757:
747:The Merck Index
743:
736:
729:
721:
717:
712:
671:
654:
646:
641:
621:
604:
580:
575:
536:slow heart rate
532:
498:
462:
460:
457:(what is this?)
454:
449:
446:
441:
436:
435:
424:
421:
416:
415:
380:
355:
345:
339:
333:
294:
270:
262:
242:
222:
202:
182:
162:
145:
137:
117:
114:
101:
100:
84:
28:
23:
22:
15:
12:
11:
5:
3755:
3745:
3744:
3739:
3734:
3729:
3724:
3719:
3702:
3701:
3699:
3698:
3689:
3680:
3671:
3662:
3653:
3644:
3631:
3628:
3627:
3624:
3623:
3621:
3620:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3253:Dexpropranolol
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3049:
3047:
3043:
3042:
3040:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2954:
2949:
2944:
2939:
2934:
2929:
2924:
2922:Norepinephrine
2919:
2914:
2909:
2904:
2899:
2894:
2889:
2887:Levosalbutamol
2884:
2876:
2874:-Phenylalanine
2868:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2776:
2771:
2766:
2761:
2756:
2747:
2742:
2737:
2732:
2727:
2722:
2717:
2712:
2707:
2702:
2697:
2692:
2687:
2682:
2677:
2672:
2667:
2662:
2657:
2651:
2649:
2642:
2636:
2635:
2632:
2631:
2629:
2628:
2623:
2608:chlorpromazine
2601:
2596:
2591:
2586:
2581:
2576:
2571:
2566:
2561:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2444:
2402:
2397:
2392:
2387:
2382:
2376:
2374:
2370:
2369:
2367:
2366:
2364:Xylometazoline
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2326:
2321:
2316:
2311:
2306:
2301:
2296:
2291:
2286:
2281:
2276:
2274:Norepinephrine
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2223:
2221:-Phenylalanine
2215:
2207:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2158:
2153:
2148:
2143:
2138:
2133:
2124:
2119:
2114:
2109:
2104:
2099:
2094:
2089:
2083:
2081:
2074:
2070:
2065:
2064:
2061:
2060:
2058:
2057:
2052:
2047:
2042:
2027:chlorpromazine
2020:
2015:
1989:
1971:
1966:
1961:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1916:
1911:
1886:
1881:
1876:
1871:
1866:
1861:
1856:
1851:
1846:
1841:
1836:
1831:
1826:
1821:
1816:
1811:
1806:
1801:
1796:
1791:
1786:
1781:
1776:
1746:
1741:
1736:
1731:
1726:
1721:
1716:
1686:
1681:
1655:
1650:
1645:
1640:
1635:
1630:
1624:
1622:
1618:
1617:
1615:
1614:
1612:Xylometazoline
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1567:Norepinephrine
1564:
1559:
1554:
1549:
1544:
1539:
1534:
1526:
1524:-Phenylalanine
1518:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1466:
1461:
1456:
1451:
1446:
1437:
1432:
1427:
1422:
1417:
1411:
1409:
1402:
1398:
1393:
1392:
1382:
1381:
1374:
1367:
1359:
1351:
1350:
1325:
1300:
1279:
1260:
1230:
1214:
1188:
1177:. 29 June 2009
1162:
1100:
1076:
1029:
1010:(1–3): e12-6.
991:
939:
915:
886:(3): 264–271.
866:
832:
825:
805:
770:
755:
734:
714:
713:
711:
708:
704:North Carolina
682:date rape drug
675:South Carolina
670:
667:
653:
650:
645:
642:
640:
637:
620:
617:
603:
600:
579:
576:
574:
571:
531:
528:
502:dilated pupils
497:
494:
469:
468:
451:
450:
448:
447:
444:
442:
439:
431:
430:
429:
426:
425:
423:
422:
419:
411:
410:
409:
406:
405:
402:
396:
395:
388:
382:
381:
379:
378:
370:
368:
360:
359:
353:
347:
346:
343:
337:
331:
326:
320:
319:
315:
314:
304:
296:
295:
293:
292:
279:
277:
264:
263:
261:
260:
252:
250:
244:
243:
241:
240:
232:
230:
224:
223:
221:
220:
212:
210:
204:
203:
201:
200:
192:
190:
184:
183:
181:
180:
172:
170:
164:
163:
161:
160:
152:
150:
139:
138:
136:
135:
127:
125:
119:
118:
116:
115:
104:
96:
95:
94:
91:
90:
86:
85:
83:
82:
59:
57:
51:
50:
46:
45:
26:
9:
6:
4:
3:
2:
3754:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3714:
3712:
3696:
3695:
3690:
3687:
3686:
3681:
3678:
3677:
3672:
3669:
3668:
3663:
3660:
3659:
3658:Serotonergics
3654:
3651:
3650:
3649:Dopaminergics
3645:
3642:
3641:
3638:
3633:
3632:
3629:
3619:
3616:
3614:
3611:
3609:
3606:
3604:
3601:
3599:
3596:
3594:
3591:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3403:Levobetaxolol
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3243:Cyanopindolol
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3050:
3048:
3044:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2953:
2950:
2948:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2928:
2927:Orciprenaline
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2877:
2875:
2869:
2867:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2828:Hexoprenaline
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2753:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2686:
2683:
2681:
2678:
2676:
2673:
2671:
2668:
2666:
2663:
2661:
2658:
2656:
2653:
2652:
2650:
2646:
2643:
2641:
2637:
2627:
2624:
2621:
2617:
2613:
2609:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2489:Esmirtazapine
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2464:
2460:
2456:
2452:
2448:
2445:
2442:
2438:
2434:
2430:
2426:
2422:
2418:
2414:
2413:brexpiprazole
2410:
2406:
2403:
2401:
2398:
2396:
2393:
2391:
2388:
2386:
2383:
2381:
2378:
2377:
2375:
2371:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2279:Oxymetazoline
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2224:
2222:
2216:
2214:
2208:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2159:
2157:
2154:
2152:
2149:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2130:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2107:Apraclonidine
2105:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2084:
2082:
2078:
2075:
2073:
2066:
2056:
2053:
2051:
2048:
2046:
2043:
2040:
2036:
2032:
2028:
2024:
2021:
2019:
2016:
2013:
2009:
2005:
2001:
1997:
1996:amitriptyline
1993:
1990:
1987:
1983:
1979:
1975:
1972:
1970:
1967:
1965:
1962:
1960:
1957:
1955:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1930:
1927:
1925:
1922:
1920:
1917:
1915:
1912:
1909:
1908:triazoledione
1905:
1901:
1897:
1893:
1890:
1887:
1885:
1882:
1880:
1877:
1875:
1872:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1815:
1812:
1810:
1807:
1805:
1802:
1800:
1797:
1795:
1792:
1790:
1787:
1785:
1782:
1780:
1777:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
1747:
1745:
1742:
1740:
1737:
1735:
1732:
1730:
1727:
1725:
1722:
1720:
1717:
1714:
1710:
1706:
1702:
1698:
1694:
1690:
1689:Beta blockers
1687:
1685:
1682:
1679:
1675:
1671:
1667:
1663:
1662:brexpiprazole
1659:
1656:
1654:
1651:
1649:
1646:
1644:
1641:
1639:
1636:
1634:
1631:
1629:
1626:
1625:
1623:
1619:
1613:
1610:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1582:Phenylephrine
1580:
1578:
1577:Oxymetazoline
1575:
1573:
1570:
1568:
1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1533:
1527:
1525:
1519:
1517:
1511:
1509:
1508:Isometheptene
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1467:
1465:
1462:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1443:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1412:
1410:
1406:
1403:
1401:
1394:
1390:
1387:
1380:
1375:
1373:
1368:
1366:
1361:
1360:
1357:
1340:
1336:
1329:
1315:
1311:
1304:
1296:
1295:
1290:
1283:
1275:
1271:
1264:
1248:
1241:
1234:
1226:
1225:
1218:
1202:
1198:
1192:
1176:
1172:
1166:
1158:
1154:
1149:
1144:
1139:
1134:
1130:
1126:
1122:
1118:
1111:
1104:
1090:
1086:
1085:"Tetryzoline"
1080:
1072:
1068:
1064:
1060:
1056:
1052:
1048:
1044:
1036:
1034:
1025:
1021:
1017:
1013:
1009:
1005:
998:
996:
987:
983:
978:
973:
969:
965:
962:(4): 388–91.
961:
957:
953:
946:
944:
929:
925:
924:"Tetryzoline"
919:
911:
907:
902:
897:
893:
889:
885:
881:
877:
870:
855:
851:
847:
841:
839:
837:
828:
822:
818:
817:
809:
790:
783:
777:
775:
766:
762:
758:
752:
748:
741:
739:
725:
719:
715:
707:
705:
700:
698:
694:
690:
685:
683:
678:
676:
666:
663:
659:
649:
636:
634:
631:. It has two
630:
626:
616:
614:
609:
599:
597:
593:
589:
585:
584:alpha agonist
570:
568:
563:
561:
557:
553:
549:
545:
541:
537:
527:
524:
522:
518:
514:
509:
507:
503:
493:
491:
487:
483:
479:
475:
465:
458:
452:
443:
438:
437:
434:
427:
418:
417:
414:
407:
403:
401:
397:
393:
389:
387:
386:Melting point
383:
376:
372:
371:
369:
366:
361:
354:
352:
348:
327:
325:
321:
316:
312:
308:
305:
303:
301:ECHA InfoCard
297:
289:
285:
284:DTXSID1047861
281:
280:
278:
269:
265:
258:
254:
253:
251:
249:
245:
238:
234:
233:
231:
229:
225:
218:
214:
213:
211:
209:
205:
198:
194:
193:
191:
189:
185:
178:
174:
173:
171:
169:
165:
158:
154:
153:
151:
144:
140:
133:
129:
128:
126:
124:
120:
112:
108:
103:
102:
99:
92:
87:
79:
74:
69:
64:
61:
60:
58:
56:
52:
49:Clinical data
47:
43:
38:
30:
19:
3727:Imidazolines
3692:
3683:
3674:
3665:
3656:
3647:
3636:
3635:
3428:Metipranolol
3413:Levomoprolol
3358:Idropranolol
2853:Isoprenaline
2751:
2675:Arformoterol
2620:thioridazine
2612:fluphenazine
2584:Spiroxatrine
2544:Phentolamine
2463:tandospirone
2429:paliperidone
2323:
2319:Tasipimidine
2299:Rezatomidine
2244:Medetomidine
2128:
2039:thioridazine
2031:fluphenazine
2012:trimipramine
2000:clomipramine
1884:Phentolamine
1753:acetergamine
1729:Corynanthine
1596:
1441:
1342:. Retrieved
1338:
1328:
1317:. Retrieved
1313:
1303:
1292:
1282:
1273:
1263:
1251:. Retrieved
1233:
1223:
1217:
1205:. Retrieved
1200:
1191:
1179:. Retrieved
1174:
1165:
1120:
1116:
1103:
1092:. Retrieved
1088:
1079:
1049:(9): 810–4.
1046:
1042:
1007:
1003:
959:
955:
931:. Retrieved
927:
918:
883:
879:
869:
858:. Retrieved
849:
815:
808:
796:. Retrieved
746:
718:
701:
686:
679:
672:
669:Criminal use
658:urban legend
655:
652:Urban legend
647:
622:
605:
581:
573:Pharmacology
564:
533:
525:
510:
505:
499:
496:Side effects
490:nasal sprays
481:
473:
472:
461:
455:
110:
106:
29:
3553:Spirendolol
3528:Propranolol
3523:Propafenone
3518:Pronethalol
3408:Levobunolol
3383:Isoxaprolol
3368:Indopanolol
3353:ICI-118,551
3318:Eugenodilol
3303:Ersentilide
3283:Draquinolol
3278:Diprafenone
3248:Dalbraminol
3228:Cicloprolol
3203:Carpindolol
3188:Butofilolol
3133:Bornaprolol
3078:Alprenoxime
3046:Antagonists
3007:Tulobuterol
3002:Tretoquinol
2997:Terbutaline
2957:Ractopamine
2952:Prenalterol
2858:Isoxsuprine
2843:Indacaterol
2813:Eugenodilol
2803:Etilevodopa
2788:Epinephrine
2779:Droxidopa (
2759:Dipivefrine
2730:Clenbuterol
2574:Setiptiline
2564:Rauwolscine
2539:Pardoprunox
2529:Mirtazapine
2494:Fenmetozole
2437:risperidone
2400:Atipamezole
2373:Antagonists
2329:Tiamenidine
2324:Tetryzoline
2304:Rilmenidine
2269:Naphazoline
2205:Guanoxabenz
2180:Epinephrine
2170:Etilevodopa
2161:Droxidopa (
2151:Dipivefrine
2112:Brimonidine
1982:maprotiline
1859:Pardoprunox
1854:Niguldipine
1814:Mepiprazole
1789:Hydroxyzine
1779:Etoperidone
1769:nicergoline
1739:Domesticine
1734:Dapiprazole
1709:eugenodilol
1684:Benoxathian
1678:risperidone
1643:Anisodamine
1621:Antagonists
1602:Tiamenidine
1597:Tetryzoline
1562:Naphazoline
1547:Methoxamine
1542:Metaraminol
1488:Etilevodopa
1478:Epinephrine
1469:Droxidopa (
1459:Dipivefrine
1420:Amidephrine
1253:3 September
1243:(Newspaper)
1207:4 September
702:In 2019, a
633:enantiomers
629:imidazoline
552:hypothermia
474:Tetryzoline
358: g·mol
307:100.001.384
237:CHEBI:28674
89:Identifiers
34:Tetryzoline
3711:Categories
3618:Xipranolol
3608:Toliprolol
3598:Tiprenolol
3583:Tienoxolol
3578:Tertatolol
3563:Sulfinalol
3543:Soquinolol
3538:Ronactolol
3513:Procinolol
3508:Primidolol
3493:Penbutolol
3473:Pacrinolol
3468:Oxprenolol
3463:Nipradilol
3433:Metoprolol
3423:Mepindolol
3418:Medroxalol
3388:Isamoltane
3378:Iprocrolol
3338:Flusoxolol
3328:Falintolol
3308:Esatenolol
3258:Diacetolol
3238:Cloranolol
3218:Celiprolol
3213:Carvedilol
3193:Capsinolol
3178:Butaxamine
3173:Bupranolol
3163:Bunitrolol
3143:Bucindolol
3138:Brefonalol
3128:Bopindolol
3123:Bisoprolol
3118:Bevantolol
3098:Arotinolol
3083:Amosulalol
3073:Alprenolol
3053:Acebutolol
3032:Zilpaterol
3017:Vilanterol
2992:Solabegron
2987:Salmeterol
2982:Salbutamol
2967:Reproterol
2962:Procaterol
2947:Pirbuterol
2932:Oxyfedrine
2917:Mirabegron
2912:Methyldopa
2902:Melevodopa
2892:Lubabegron
2848:Isoetarine
2833:Higenamine
2823:Formoterol
2798:Etilefrine
2793:Etafedrine
2774:Dopexamine
2764:Dobutamine
2745:Denopamine
2740:Corbadrine
2720:Carmoterol
2715:Carbuterol
2705:Broxaterol
2700:Bitolterol
2690:Bambuterol
2680:Arotinolol
2670:Arbutamine
2660:Alifedrine
2655:Abediterol
2599:Tolazoline
2589:Sunepitron
2579:Spegatrine
2569:Rotigotine
2509:Ketanserin
2499:Fluparoxan
2479:Cirazoline
2474:Buflomedil
2459:ipsapirone
2447:Azapirones
2433:quetiapine
2425:olanzapine
2421:lurasidone
2395:Aptazapine
2390:Amesergide
2339:Tolonidine
2334:Tizanidine
2314:Talipexole
2309:Romifidine
2264:Moxonidine
2254:Methyldopa
2249:Melevodopa
2239:Lofexidine
2200:Guanfacine
2185:Etilefrine
2175:Ergotamine
2136:Detomidine
2122:Corbadrine
2018:Trimazosin
2008:imipramine
1969:Tolazoline
1964:Tiodazosin
1954:Tamsulosin
1949:Talipexole
1939:Spegatrine
1924:Quinazosin
1900:nefazodone
1874:Phendioxan
1864:Pelanserin
1849:Niaprazine
1844:Neldazosin
1834:Naftopidil
1829:Moxisylyte
1799:Ketanserin
1784:Fenspiride
1757:ergotamine
1719:Buflomedil
1705:carvedilol
1701:arotinolol
1697:amosulalol
1674:quetiapine
1670:olanzapine
1633:Ajmalicine
1592:Synephrine
1572:Octopamine
1552:Methyldopa
1537:Melevodopa
1503:Indanidine
1483:Etilefrine
1435:Corbadrine
1430:Cirazoline
1389:modulators
1344:2022-09-15
1319:2022-09-15
1094:2022-12-21
933:2022-09-15
860:2018-09-05
724:US 2731471
710:References
625:derivative
596:antazoline
363:3D model (
351:Molar mass
257:ChEMBL1266
197:S9U025Y077
168:ChemSpider
123:CAS Number
113:-imidazole
98:IUPAC name
3732:Tetralins
3637:See also:
3613:Xibenolol
3603:Tolamolol
3588:Tilisolol
3568:Talinolol
3558:SR 59230A
3533:Ridazolol
3503:Practolol
3483:Pamatolol
3478:Pafenolol
3458:Nifenalol
3453:Nebivolol
3448:Nadoxolol
3398:Landiolol
3393:Labetalol
3363:Indenolol
3333:Flestolol
3323:Exaprolol
3288:Ecastolol
3273:Dilevalol
3233:Cinamolol
3223:Cetamolol
3208:Carteolol
3198:Carazolol
3183:Butidrine
3158:Bufuralol
3153:Bufetolol
3148:Bucumolol
3113:Betaxolol
3108:Befunolol
3088:Ancarolol
3058:Adaprolol
3022:Xamoterol
2977:Ritodrine
2972:Rimiterol
2937:PF-610355
2897:Mabuterol
2882:-Tyrosine
2838:Ibopamine
2818:Fenoterol
2725:Cimaterol
2710:Buphenine
2695:Befunolol
2665:Amibegron
2626:Yohimbine
2594:Terguride
2559:Piribedil
2554:Piperoxan
2524:Mianserin
2469:BRL-44408
2451:buspirone
2417:clozapine
2409:asenapine
2349:Vatinoxan
2289:Piperoxan
2259:Mivazerol
2234:Ibopamine
2229:-Tyrosine
2195:Guanabenz
2117:Clonidine
2055:Zolertine
1986:mianserin
1978:amoxapine
1959:Terazosin
1944:Spiperone
1934:Silodosin
1929:Quinidine
1914:Piperoxan
1904:trazodone
1869:Perlapine
1839:Nantenine
1824:Monatepil
1819:Metazosin
1804:L-765,314
1794:Indoramin
1773:terguride
1749:Ergolines
1744:Doxazosin
1724:Bunazosin
1713:labetalol
1666:clozapine
1653:Atiprosin
1648:Anisodine
1638:Alfuzosin
1628:Abanoquil
1557:Midodrine
1532:-Tyrosine
1498:Ibopamine
1425:Buspirone
1138:2164/6048
798:30 August
619:Chemistry
486:eye drops
3498:Pindolol
3488:Pargolol
3438:Moprolol
3313:Esprolol
3298:Ericolol
3293:Epanolol
3103:Atenolol
3068:Afurolol
3063:Adimolol
3037:Zinterol
3012:Vibegron
2769:Dopamine
2735:Colterol
2648:Agonists
2616:loxapine
2514:Lisuride
2504:Idazoxan
2484:Efaroxan
2455:gepirone
2441:zotepine
2385:Adimolol
2359:Xylazine
2344:Urapidil
2156:Dopamine
2080:Agonists
2045:Urapidil
2035:loxapine
1919:Prazosin
1765:lisuride
1693:adimolol
1464:Dopamine
1408:Agonists
1314:ABC News
1294:ABC News
1274:ABC News
1247:Archived
1157:26028608
1148:10616535
1071:20238499
1063:21972870
1024:22554870
986:24760708
910:29461408
854:Archived
789:Archived
765:46987702
586:for the
530:Overdose
521:rhinitis
506:increase
464:(verify)
55:ATC code
3593:Timolol
3573:Tazolol
3548:Sotalol
3443:Nadolol
3168:Bunolol
3093:Arnolol
3027:XP21279
2606:(e.g.,
2534:NAN-190
2449:(e.g.,
2407:(e.g.,
2354:XP21279
2102:Amitraz
2050:WB-4101
2025:(e.g.,
2004:doxepin
1994:(e.g.,
1976:(e.g.,
1894:(e.g.,
1751:(e.g.,
1691:(e.g.,
1660:(e.g.,
1607:XP21279
1181:28 July
977:4252297
901:5839712
356:200.285
324:Formula
143:PubChem
132:84-22-0
75: (
73:S01GA02
71:)
65: (
63:R01AA06
2783:-DOPS)
2165:-DOPS)
2092:4-NEMD
1473:-DOPS)
1339:Forbes
1175:Snopes
1155:
1145:
1069:
1061:
1022:
984:
974:
908:
898:
823:
763:
753:
730:
697:Visine
662:Visine
513:mucosa
413:SMILES
248:ChEMBL
217:D08578
2097:6-FNE
1415:6-FNE
1113:(PDF)
1067:S2CID
792:(PDF)
785:(PDF)
644:Names
433:InChI
394:-salt
365:JSmol
228:ChEBI
2685:BAAM
2519:mCPP
2380:1-PP
2294:PS75
1809:mCPP
1255:2018
1209:2018
1183:2010
1153:PMID
1121:2015
1059:PMID
1020:PMID
982:PMID
906:PMID
821:ISBN
800:2016
761:OCLC
751:ISBN
488:and
208:KEGG
188:UNII
177:5226
157:5419
1201:BBC
1143:PMC
1133:hdl
1125:doi
1051:doi
1012:doi
1008:221
972:PMC
964:doi
896:PMC
888:doi
656:An
627:of
478:INN
392:HCl
273:EPA
147:CID
78:WHO
68:WHO
3713::
2618:,
2614:,
2610:,
2461:,
2457:,
2453:,
2439:,
2435:,
2431:,
2427:,
2423:,
2419:,
2415:,
2411:,
2037:,
2033:,
2029:,
2010:,
2006:,
2002:,
1998:,
1984:,
1980:,
1906:,
1902:,
1898:,
1771:,
1767:,
1763:,
1759:,
1755:,
1711:,
1707:,
1703:,
1699:,
1695:,
1676:,
1672:,
1668:,
1664:,
1337:.
1312:.
1291:.
1272:.
1199:.
1173:.
1151:.
1141:.
1131:.
1119:.
1115:.
1087:.
1065:.
1057:.
1047:49
1045:.
1032:^
1018:.
1006:.
994:^
980:.
970:.
960:10
958:.
954:.
942:^
926:.
904:.
894:.
884:95
882:.
878:.
852:.
848:.
835:^
773:^
759:.
737:^
699:.
635:.
613:ng
598:.
550:,
546:,
542:,
538:.
338:16
332:13
107:RS
2880:L
2872:L
2864:L
2781:L
2752:N
2640:β
2622:)
2465:)
2443:)
2227:L
2219:L
2211:L
2163:L
2129:N
2071:2
2069:α
2041:)
2014:)
1988:)
1910:)
1775:)
1715:)
1680:)
1530:L
1522:L
1514:L
1471:L
1442:N
1399:1
1397:α
1378:e
1371:t
1364:v
1347:.
1322:.
1297:.
1276:.
1257:.
1211:.
1185:.
1159:.
1135::
1127::
1097:.
1073:.
1053::
1026:.
1014::
988:.
966::
936:.
912:.
890::
863:.
829:.
802:.
767:.
476:(
367:)
344:2
341:N
335:H
329:C
275:)
271:(
111:H
105:(
81:)
20:)
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