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method of inoculation used was to apply a sample of gonorrhea to the end of the test subjects' penises. However, after five months of using this method for inoculation, researchers became concerned with the inconsistency. The leader of the experiment, Dr. Mahoney, reported his unsuccessful attempts at inoculation to the
National Research Council. The NRC encouraged the continuation of the experiment. Dr. Cutler, who had been working alongside Dr. Mahoney, tried additional attempts at inoculation but was unsuccessful.
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argument but worried about the public reaction to this experiment. Gonorrhea was becoming a growing problem amongst all areas of the population and the only way to study it was through human experimentation. The NRC eventually endorsed this study because they thought the benefits of creating prophylaxis treatments for gonorrhea outweighed the risks of a negative public reaction.
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The study was conducted in Terre Haute, Indiana at a state penitentiary in
September 1943. There were three locations considered for this experiment, but Terre Haute was chosen due to their superior medical facility. There were 241 test subjects chosen from the prison. The requirements to participate
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After many different failed attempts at inoculation, Dr. Mahoney decided to end the experiment. Dr. Mahoney realized that without a consistent way to inoculate test subjects, they could not effectively test prophylaxis treatments. The Terre Haute Prison experiments were conducted for only ten months
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During an NRC meeting about venereal diseases, two researchers from New York proposed the idea of using volunteer prison inmates as test subjects. They argued that inmates were the ideal test subject because they could be well monitored and prohibited from sexual activity. The NRC agreed with their
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The researcher's initial task was to find a consistent method of inoculation. The researchers had taken samples of gonorrhea from recently arrested sex workers. They gathered many different strains of gonorrhea and experimented with inoculating the test subjects with different concentrations. The
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in the experiment were that you be at least 21 years old and fully understood the risks involved. The prisoners signed waivers and were told they would receive $ 100 and a letter of recommendation for parole after completing the experiment.
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did not have a medical treatment at this time and was difficult to study because only humans can contract it. This initiated extensive research on how to prevent and treat gonorrhea to reduce infection rates in the armed forces.
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into the penises of the test subjects. After several months, Mahoney noted that the method of inducing gonorrhea in humans was unreliable and could not provide meaningful tests of prophylactic agents.
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After the Terre Haute Prison
Experiments, Dr. Mahoney and Dr. Cutler continued their experiments on venereal diseases in the Guatemala Syphilis experiments.
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This study was conducted by Dr. John Cutler, Dr. John
Mahoney, Dr. Thomas Parran, Dr. Joseph Earle Moore, and Dr. Cassius J. Van Slyke.
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to create a prophylaxis treatment for gonorrhea. Venereal diseases had been an issue previously during
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The progress of experiment: Science and therapeutic reform in the United States 1900–1990
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The Terre Haute experiments laid the foundation for and bore many similarities to the
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Human experimentation conducted on prisoners in Terre Haute, Indiana
205:"Ethically Impossible" STD Research in Guatemala from 1946 to 1948
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History of syphilis: a night with Venus, a lifetime with
Mercury
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Presidential
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and had cost the army seven million days of active duty.
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62:Experiment overview
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122:Continued research
67:Historical context
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