867:
853:
844:
830:
38:
860:
837:
483:
460:
47:
1936:
1547:
718:
in children with blood level measured above 45 μg/dL. The use of dimercaptosuccinic acid is not approved for prevention of lead poisoning in anticipation of exposure in known lead-contaminated environments. Dimercaptosuccinic acid can cross the
726:
Succimer facilitates urinary excretion of lead, and with sufficiently aggressive treatment, can reduce lead content in the brain. It also increases urinary excretion of copper and zinc. Dimercaptosuccinic acid improved cognitive function in
1545:, Lindemann MK, Lukenbach ER, "Process for the preparation of 2,3-dimercaptosuccinic acid and its lower alkyl esters", issued 29 October 1985, assigned to Johnson & Johnson Baby Products
723:
of mice, but it is not known if this is also the case in humans. Even if dimercaptosuccinic acid cannot reverse the damages done to the central nervous system, it might prevent further deterioration.
1328:
Aaseth J, Jacobsen D, Andersen O, Wickstrøm E (March 1995). "Treatment of mercury and lead poisonings with dimercaptosuccinic acid and sodium dimercaptopropanesulfonate. A review".
1590:
Liang Y, Chu C, Tsen Y, Ting K (1957). "Studies on antibilharzial drugs. Vl. The antidotal effects of sodium dimercaptosuccinate and BAL-glucoside against tartar emetic".
1674:
Aposhian HV, Aposhian MM (1990). "meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent".
1617:
1647:
1976:
1007:
186:
971:
552:
1018:
status under the brand name Chemet and the FDA approved of this in 1991, providing exclusivity until 1998 which was conveyed to the successor
138:
576:
1261:
1173:
1725:
1091:
1065:
1039:
685:
family of medications. It works by binding with lead and a number of other heavy metals, allowing them to leave the body in the
1609:
1971:
1890:
1861:
693:
866:
852:
843:
829:
1414:
Clarkson TW, Magos L, Myers GJ (October 2003). "The toxicology of mercury--current exposures and clinical manifestations".
1195:
1134:
1092:"Rotop - DMSA- kit for the preparation of technetium tc99m succimer injection injection, powder, lyophilized, for solution"
1639:
859:
836:
37:
1217:
Miller AL (June 1998). "Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity".
1312:
1255:
1167:
596:
175:
1907:
1810:
249:
216:
156:
1718:
958:, mobilizing these ions for excretion. It binds to metal cations through the thiol groups, which ionize upon
478:
359:
986:
and was looking for a medicine to prevent poisoning of personnel. In 1957, Chinese scientists found that
428:
1956:
975:
731:
that had been exposed to lead, but reduced cognitive function in rats that had not been exposed to lead.
439:
1926:
1703:
928:
1542:
1966:
1711:
1275:
455:
1895:
1866:
987:
720:
101:
1503:"Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning"
1563:
959:
1245:
1157:
408:
1561:
Gerecke M, Friedheim EA, Brossi A (1961). "Zur
Kenntnis der 2,3-Dimercapto-bernsteinsäuren".
740:
348:
1380:
1337:
368:
8:
739:
Succimer is an isomer of 2,3-dimercaptosuccinic acid. 2,3-dimercaptosuccinic acid is the
659:
283:
274:
1687:
1384:
1341:
763:
groups, the latter being responsible for its mildly unpleasant odour. It occurs in two
662:. A second course should be given when more than two weeks pass after the first course.
482:
459:
1478:
1453:
979:
932:
697:
674:
643:
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231:
308:
1683:
1572:
1514:
1473:
1465:
1423:
1388:
1371:
Guzzi G, La Porta CA (February 2008). "Molecular mechanisms triggered by mercury".
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64:
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22:
1901:
715:
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647:
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1950:
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in 1962. In 1984, the now-defunct Bock
Pharmaceutical Company requested the
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815:
764:
563:
471:
1787:
1528:
1519:
1502:
1487:
1435:
1400:
1280:
World Health
Organization model list of essential medicines: 21st list 2019
783:
775:
194:
1695:
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1815:
1805:
1782:
1777:
1427:
1349:
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29:
1733:
1288:
604:
InChI=1S/C4H6O4S2/c5-3(6)1(9)2(10)4(7)8/h1-2,9-10H,(H,5,6)(H,7,8)/t1-,2+
328:
1454:"The scientific basis for chelation: animal studies and lead chelation"
803:
627:
528:
339:
1734:
709:
678:
294:
142:
1827:
1066:"Nephroscan- succimer injection, powder, lyophilized, for solution"
991:
681:
is safe for the baby is unclear. Dimercaptosuccinic acid is in the
388:
319:
170:
1614:
Searchable database for Orphan
Designated and or Approved Products
551:
999:
46:
1751:
1327:
1019:
692:
Succimer has been used medically since the 1950s. It is on the
419:
88:
1856:
940:
760:
686:
542:
399:
16:
Medication used to treat lead, mercury, and arsenic poisoning
444:
1797:
1769:
955:
379:
1541:
1305:
665:
Common side effects include vomiting, diarrhea, rash, and
1274:
1243:
1011:
728:
82:
73:
1292:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
998:. Pronounced protective effect in animal poisoning with
978:, commissioned by one of the electrical enterprises of
694:
1560:
1162:. Springer Science & Business Media. p. 213.
1924:
1133:. The American Society of Health-System Pharmacists.
1046:. U.S. National Library of Medicine. 12 December 2019
79:
76:
70:
1500:
927:
Dimercaptosuccinic acid may be prepared by reacting
85:
67:
1413:
1098:. U.S. National Library of Medicine. 9 March 2021
1072:. U.S. National Library of Medicine. 1 March 2022
970:Dimercaptosuccinic acid was first synthesized by
774:The 2,3-dimercaptosuccinic acid molecule has two
1948:
1673:
1589:
1155:
307:
21:"Chemet" redirects here. For the violinist, see
1610:"Search Orphan Drug Designations and Approvals"
1501:Bradberry S, Sheehan T, Vale A (October 2009).
1447:
1445:
1244:Chappell WR, Abernathy CO, Calderon RL (1999).
282:
1307:. Jones & Bartlett Learning. p. 472.
1977:World Health Organization essential medicines
1719:
1370:
922:
1676:Annual Review of Pharmacology and Toxicology
1494:
1442:
677:may also occur with use. Whether use during
174:
1451:
714:Succimer is indicated for the treatment of
1726:
1712:
1125:
1123:
1121:
1119:
1117:
1115:
1113:
946:Meso 2,3-dimercaptosuccinic acid binds to
481:
458:
347:
45:
36:
1518:
1477:
1287:
782:atoms), and can exist as three different
367:
1640:"Sanofi Buying An American Drug Concern"
1302:
1188:"Succimer (Chemet) Use During Pregnancy"
1296:
1247:Arsenic Exposure and Health Effects III
1110:
454:
327:
1949:
1268:
1216:
755:H. This colorless solid contains two
472:
1707:
1282:. Geneva: World Health Organization.
939:followed by hydrolysis. The dimethyl
427:
407:
225:
165:
147:
1650:from the original on 6 November 2014
1620:from the original on 6 November 2014
1452:Smith D, Strupp BJ (December 2013).
1198:from the original on 16 January 2017
1137:from the original on 16 January 2017
198:
1688:10.1146/annurev.pa.30.040190.001431
1416:The New England Journal of Medicine
387:
298:
13:
1666:
14:
1988:
658:of Succimer lasts for 19 days of
1934:
1264:from the original on 2017-01-13.
1176:from the original on 2017-01-13.
1156:Biersack HJ, Grünwald F (2005).
865:
858:
851:
842:
835:
828:
506:
265:)-2,3-disulfanylbutanedioic acid
63:
1632:
1602:
1583:
1554:
1535:
1407:
1364:
1321:
703:
609:Key:ACTRVOBWPAIOHC-XIXRPRMCSA-N
1237:
1210:
1180:
1149:
1084:
1058:
1032:
982:, which consumed many tons of
650:, it is used in many types of
518:
512:
500:
1:
1458:Journal of Medical Toxicology
1025:
994:poisoning due to overdose of
915:)-2,3-dimercaptosuccinic acid
902:-2,3-dimercaptosuccinic acid)
896:)-2,3-dimercaptosuccinic acid
883:)-2,3-dimercaptosuccinic acid
126:)-2,3-Dimercaptosuccinic acid
1972:Peripherally selective drugs
734:
622:, sold under the brand name
131:-2,3-Dimercaptosuccinic acid
7:
1219:Alternative Medicine Review
976:Urals Polytechnic Institute
696:. In the United States, no
667:low blood neutrophil levels
10:
1993:
1040:"Chemet- succimer capsule"
965:
929:acetylenedicarboxylic acid
923:Preparation and reactivity
707:
700:was available as of 2015.
490:Chemical and physical data
20:
1885:
1844:
1826:
1796:
1768:
1750:
1470:10.1007/s13181-013-0339-2
1393:10.1016/j.tox.2007.11.002
1276:World Health Organization
1250:. Elsevier. p. 350.
592:
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568:125 °C (257 °F)
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1577:10.1002/hlca.19610440410
988:dimercaptosuccinic acid
814:isomer (succimer) is a
114:Dimercaptosuccinic acid
1564:Helvetica Chimica Acta
990:can effectively treat
802:isomers are a pair of
767:, meso and the chiral
950:heavy metals such as
741:organosulfur compound
1520:10.1093/qjmed/hcp114
1428:10.1056/nejmra022471
1350:10.1039/an9952000853
1385:2008Toxgy.244....1G
1342:1995Ana...120..853A
1303:Hamilton R (2015).
1014:grant approval for
1008:I. E. Okonishnikova
1006:was first shown by
721:blood–brain barrier
660:oral administration
626:among others, is a
32:
1957:Dicarboxylic acids
1912:Never to phase III
1644:The New York Times
980:Sverdlovsk, Russia
933:sodium thiosulfate
820:optically inactive
675:allergic reactions
652:diagnostic testing
584:O=C(O)(S)(S)C(=O)O
28:
1922:
1921:
1739:chelation therapy
1646:. July 17, 1996.
1592:Acta Physiol. Sin
1422:(18): 1731–1737.
920:
919:
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780:asymmetric carbon
640:arsenic poisoning
617:
616:
553:Interactive image
440:CompTox Dashboard
229:
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1984:
1967:Chelating agents
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1735:Chelating agents
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972:V. L. Nirenburg
968:
943:is also known.
937:thioacetic acid
925:
897:
806:, whereas the 2
757:carboxylic acid
754:
751:CCH(SH)CH(SH)CO
750:
737:
712:
706:
698:generic version
683:chelating agent
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1682:(1): 279–306.
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1159:Thyroid Cancer
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671:Liver problems
648:technetium-99m
630:used to treat
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1616:. FDA. 2013.
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211:Legal status
157:License data
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1898:from market
1816:Dexrazoxane
1783:Deferiprone
1778:Deferasirox
1379:(1): 1–12.
1330:The Analyst
1016:orphan drug
804:enantiomers
536: g·mol
479:100.005.597
409:CHEBI:63623
241:Identifiers
111:Other names
102:Trade names
1951:Categories
1654:5 November
1624:5 November
1543:US 4550193
1373:Toxicology
1202:12 January
1131:"Succimer"
1026:References
708:See also:
628:medication
541:3D model (
529:Molar mass
369:DX1U2629QE
340:ChemSpider
275:CAS Number
250:IUPAC name
1908:Phase III
1896:Withdrawn
1745:, others)
1141:8 January
1022:in 1996.
818:and thus
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735:Chemistry
710:DMSA scan
679:pregnancy
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149:Monograph
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1096:DailyMed
1070:DailyMed
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992:antimony
759:and two
620:Succimer
320:DrugBank
284:304-55-2
187:ATC code
176:Succimer
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1696:2160791
1479:3846979
1381:Bibcode
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1102:19 June
1076:19 June
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966:History
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232:℞-only
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794:and 2
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1867:DMSA
1862:DMPS
1811:EDTA
1798:Lead
1770:Iron
1692:PMID
1656:2014
1626:2014
1525:PMID
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1432:PMID
1397:PMID
1354:PMID
1309:ISBN
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1227:PMID
1204:2017
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