Stroke recovery - Knowledge

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motor activities has been either lost or cannot be accessed. The condition is usually due to an insult to the dominant hemisphere of the brain. More often this is located in the frontal lobe of the left hemisphere of the brain. Treatment of acquired apraxia due to stroke usually consists of physical, occupational, and speech therapy. The Copenhagen Stroke Study, which is a large important study published in 2001, showed that out of 618 stroke patients, manual apraxia was found in 7% and oral apraxia was found in 6%. Both manual and oral apraxia were related to increasing severity of stroke. Oral apraxia was related with an increase in age at the time of the stroke. There was no difference in incidence among gender. It was also found that the finding of apraxia has no negative influence on ability to function after rehabilitation is completed. The National Institute of Neurological Disorders and Stroke (NINDS) is currently sponsoring a clinical trial to gain an understanding of how the brain operates while carrying out and controlling voluntary motor movements in normal subjects. The objective is to determine what goes wrong with these processes in the course of acquired apraxia due to stroke or brain injury.

325:(PNF stretching), as well as conventional treatment approaches (utilizing traditional exercises and functional activities), etc. Despite being widely used, based on the literature, NDT has failed to demonstrate any superiority over other treatment techniques available. In fact, the techniques compared with NDT in these studies often produce similar results in terms of treatment effectiveness. Research has demonstrated significant findings for all these treatment approaches when compared with control subjects and indicate that overall, rehabilitation is effective. It is important to note, however, that the NDT philosophy of "do what works best" has led to heterogeneity in the literature in terms of what constitutes an NDT technique, thus making it difficult to directly compare to other techniques. 1006:

apraxia is the inability to create a plan for a specific movement. Buccofacial apraxia, or facial-oral apraxia, is the inability to coordinate and carry out facial and lip movements such as whistling, winking, coughing, etc. on command. Constructional apraxia affects the person's ability to draw or copy simple diagrams, or to construct simple figures. Oculomotor apraxia is a condition in which the patient finds it difficult to move his/her eyes. Many believe that the most common form of apraxia is idiomotor apraxia, in which a disconnection between the area of the brain containing plans for a movement and the area of the brain that is responsible for executing that movement occurs.

248:. These may include, but are not limited to, eating, dressing, and hygiene activities. CIMT may improve motor impairment and motor function, but the benefits have not been found to convincingly reduce disability, with further research required. Using functional activities as part of the CIMT treatment has been shown to enhance functional outcomes in one's activities of daily living. Occupational therapists are uniquely qualified to provide function-based treatment in conjunction with a CIMT approach. The greatest gains are seen among persons with stroke who exhibit some wrist and finger extension in the affected limb. 139:, and recreation therapist. The patient and their family/caregivers also play an integral role on this team. Family/caregivers that are involved in the patient care tend to be prepared for the caregiving role as the patient transitions from rehabilitation centers. While at the rehabilitation center, the interdisciplinary team makes sure that the patient attains their maximum functional potential upon discharge. The primary goals of this sub-acute phase of recovery include preventing secondary health complications, minimizing impairments, and achieving functional goals that promote independence in 1047:

like these. Typically, a commonly used tool to assess the degree of severity of dysphagia and speech issues is the Barnes Jewish Hospital Stroke Dysphagia Screen, which offers a validated guide to assessing plan of action (solid food diet, all liquid diet, IV hydration, etc.) for the patient while in the hospital and the proper course of action in the outpatient setting. Rehabilitation in Wallenberg's Syndrome focuses on improving balance, coordination, working on activities of daily living, and improving speech and swallowing function. Severe

316:, also known as Neurodevelopmental Treatment (NDT), is often the treatment of choice in North America. The Bobath concept is best viewed as a framework for interpretation and problem solving of the individual patient's presentation, along with their potential for improvement. Components of motor control that are specifically emphasized, are the integration of postural control and task performance, the control of selective movement for the production of coordinated sequences of movement and the contribution of sensory inputs to 599:-like compounds.³ The exact mechanism of these medications is not fully understood, but they are thought to act on neurotransmitters or neuromodulators within the central nervous system (CNS) or muscle itself, or to decrease the stretch reflexes. The problem with these medications is their potential side effects and the fact that, other than lessening painful or disruptive spasms and dystonic postures, drugs in general have not been shown to decrease impairments or lessen disabilities. 862:) for much of its support. This is in contrast to other less mobile joints such as the knee and hip, which have a significant amount of support from the joint capsule and surrounding ligaments. If a stroke damages the upper motor neurons controlling muscles of the upper limb, weakness and paralysis, followed by spasticity occurs in a somewhat predictable pattern. The muscles supporting the shoulder joint, particularly the 240:. Notably, the initial studies focused on chronic stroke patients who were more than 12 months past their stroke. This challenged the belief held at that time that no recovery would occur after one year. The therapy entails wearing a soft mitt on the good hand for 90% of the waking hours, forcing use of the affected hand. The patients undergo intense one-on-one therapy for six to eight hours per day for two weeks. 1114:(DSM-IV-TR) defines post-stroke depression as "a mood disorder due to a general medical condition (i.e. stroke) that is judged to be due to the direct physiological effects of condition". Post-stroke depression may involve depressed mood and decreased interest and pleasure that impairs social and occupational functioning, but does not necessarily need to meet the full criteria of a major depressive disorder. 410:(development of new neurons) is another possible mechanism of neurorestoration; however its correlation with functional improvement after stroke is not well established. The inducted cells likely originate from the ventricular zone, subventricular zone and choroid plexus, and migrate to the areas in their respective hemispheres which are damaged. Unlike the induction of neurogenesis, the induction of 435:

decompressive surgery. However, for MSC treatment to be used effectively and safely in a clinical setting, more research needs to be conducted, specifically in the areas of determining the relative influences of key variables (especially patient variables) on patient outcomes as well quantifying potential risks, e.g. tumour formation. Although ethical concerns are mostly limited to the use of

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stroke. Among the most common are lesions on specific anatomical structures, such as the hippocampus or entorhinal cortex, white matter lesions, and cerebral microbleeds. The extent and type of cognitive impairment depend on the area of the brain affected by the stroke. However, in general, most cognitive impairment always includes either memory, attention, language, or orientation problems.

272:, has been shown in many studies to be effective in promoting recovery of both arm and leg function after a stroke. It is often used by physical or occupational therapists in the rehab or homehealth setting, but can also be used as part of a patient's independent home exercise program. Mental Movement Therapy is one product available for assisting patients with guided mental imagery. 1001:. This condition was initially recognized as: 'Disorders of the execution of learned movements which cannot be accounted for by either weakness, incoordination, or sensory loss, nor by incomprehension of, or inattention to commands.' Several forms of apraxia are recognized. Limb-kinetic apraxia is the inability to make precise or exact movements with a finger, an arm or a leg. 1193:(ADLs). By effectively treating depression, patients experience a greater recovery of basic ADLs such as dressing, eating and ambulating, as well as instrumental ADLs, such as the ability to take care of financial and household matters. In essence, recognition and treatment of post-stroke depression leads to greater functional ability for the patient over time. 818:(NMES) (e.g. functional electric stimulation (FES)). The use of slings remains controversial. Functional electric stimulation (FES) is a NMES technique where nerves or muscles affected by stroke receive bursts of low-level electrical current. The goal of FES is to strengthen muscle contraction and improve motor control. It may be effective in reducing 1134:, leading to depression. However, more recent studies have demonstrated that the anatomic aspects of a lesion do not necessarily correlate with the occurrence of depression. Other psychological factors can lead to the development of depression including personal and social losses related to the physical disabilities often caused by a stroke. 426:

affect neurorestoration and neuroprotection, rather than just a single mechanism. These effects are also modulated by key variables, including the number of and type of MSCs used, timing of treatment relative to when the patient's stroke occurred, route of delivery of the MSCs, as well as patient variables (e.g. age, underlying conditions).

1214:. Daily instrumental activities can be understood as those activities that allow an individual to live independently. Even though they are not necessary for living, however, these activities may significantly improve the quality of life. Examples of these activities include cooking, transportation, laundry, and managing finances. 336:(MT) has been employed with some success in treating stroke patients. Clinical studies that have combined mirror therapy with conventional rehabilitation have achieved the most positive outcomes. However, there is no clear consensus as to its effectiveness. In a recent survey of the published research, Rothgangel concluded that 353:

function in individuals in the inpatient, outpatient and chronic care settings. These therapies have achieved the highest level of evidential support by the American Heart Association (Class I, Level of Evidence A) for the outpatient and chronic care settings and Class IIa Level of Evidence for the inpatient setting.

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Cognitive impairment is indisputably one of the biggest threats following stroke. The prevalence of cognitive impairment is quite high, however it varies based on the population within which the stroke has occurred. Many different causes can contribute to the acquirement of cognitive impairment after

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Chronic pain syndromes are common in about one half of stroke patients. Central post-stroke pain (CPSP) is neuropathic pain which is caused by damage to the neurons in the brain (central nervous system), as the result of a vascular injury. One study found that up to 8% of people who have had a stroke

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in a slow and controlled movement is a beneficial training strategy that can be used by post-stroke individuals. Splinting, to maintain muscle stretch and provide tone inhibition, and cold (i.e. in the form of ice packs), to decrease neural firing, are other strategies that can be used to temporarily

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With the prevalence of vision problems increasing with age in stroke patients, the overall effect of interventions for age-related visual problems is currently uncertain. It is also not sure whether people with stroke respond differently from the general population when treating eye problems. Further

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It has been estimated that approximately 65% of individuals develop spasticity following stroke, and studies have revealed that approximately 40% of stroke patients may still have spasticity at 12 months post-stroke. The changes in muscle tone probably result from alterations in the balance of inputs

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in patients post CVA as well. This treatment intervention is known as Constraint Induced Aphasia Therapy (CIAT). The same general principals apply, however in this case, the client is constricted from using compensatory strategies to communicate such as gestures, writing, drawing, and pointing, and

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Once a patient is medically stable, the focus of their recovery shifts to rehabilitation. Some patients are transferred to in-patient rehabilitation programs, while others may be referred to out-patient services or home-based care. In-patient programs are usually facilitated by an interdisciplinary

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recovery. Rapid detection and appropriate emergency medical care are essential for optimizing health outcomes. When available, patients are admitted to an acute stroke unit for treatment. These units specialize in providing medical and surgical care aimed at stabilizing the patient's medical status.

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Ongoing research has examined the use of cognitive therapy which consists of intense cognitive training. One of the biggest problems of cognitive training is its actual transfer to the real world. Even though some therapies have been proven to produce improvements on specific tasks, the patients did

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apraxia is the inability to carry out a command from the brain to mimic limb or head movements performed or suggested by others. Conceptual apraxia is similar to idiomotor apraxia, but infers a more profound malfunctioning in which the function of tools or objects is no longer understood. Ideational

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or armboard. A shoulder sling may be used, but is controversial and a few studies have shown no appreciable difference in range-of-motion, degree of subluxation, or pain when using a sling. A sling may also contribute to contractures and increased flexor tone if used for extended periods of time as

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or by feeling the joint and surrounding tissues, although there is controversy as to whether or not the degree of subluxation can be measured clinically. If shoulder subluxation occurs, it can become a barrier to the rehabilitation process. Treatment involves measures to support the subluxed joint

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Such work represents a paradigm shift in the approach towards rehabilitation of the stroke-injured brain away from pharmacologic flooding of neuronal receptors and instead, towards targeted physiologic stimulation. In layman's terms, this electrical stimulation mimics the action of healthy muscle to

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Around the same time, Brunnstrom also described the process of recovery, and divided the process into seven stages. As knowledge of the science of brain recovery improved, intervention strategies have evolved. Knowledge of strokes and the process of recovery after strokes has developed significantly

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Brock K, Haase G, Rothacher G, Cotton S (October 2011). "Does physiotherapy based on the Bobath concept, in conjunction with a task practice, achieve greater improvement in walking ability in people with stroke compared to physiotherapy focused on structured task practice alone?: a pilot randomized

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There has not been any medication developed yet to treat cognitive deficits resulting from strokes. Although some drugs have shown to be helpful with executive function problems, neither of them has demonstrated significant effects on activities of daily living. Thus, it is important that more work

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Unlike many effects of stroke, where the clinician is able to judge the particular area of the brain that a stroke has injured by certain signs or symptoms, the causation of apraxia is less clear. A common theory is that the part of the brain that contains information for previously learned skilled

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The exact cause of subluxation in post-stroke patients is unclear but appears to be caused by weakness of the musculature supporting the shoulder joint. The shoulder is one of the most mobile joints in the body. To provide a high level of mobility the shoulder sacrifices ligamentous stability and

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If MSC treatment becomes available for stroke patients, it is possible that current mortality and morbidity rates could substantially improve due to the direct enhancement of neuroprotection and neurorestoration mechanisms rather than only indirect facilitation or prevention of further damage, e.g.

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Although activation of endogenous neuroprotection and neurorestoration probably has a major part in the improvement of brain function after stroke, it is likely that the functional improvements as a result of MSC treatment are due to combined action via multiple cellular and molecular mechanisms to

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In the early 1950s, Twitchell began studying the pattern of recovery in stroke patients. He reported on 121 patients whom he had observed. He found that by four weeks, if there is some recovery of hand function, there is a 70% chance of making a full or good recovery. He reported that most recovery

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Treatment in the acute setting is mostly focused on symptomatic management. After initial treatment in the hospital, some patients will need short-term placement in a nursing home or rehabilitation facility before going home. In hospital settings the doctors work with speech pathologists in issues

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Intrathecal administration of drugs involves the implantation of a pump that delivers medication directly to the CNS. The benefit of this is that the drug remains in the spinal cord, without traveling in the bloodstream, and there are often fewer side effects. The most commonly used medication for

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Evidence that supports the use of constraint induced movement therapy has been growing since its introduction as an alternative treatment method for upper limb motor deficits found in stroke populations. Recently, constraint induced movement therapy has been shown to be an effective rehabilitation

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procedures with varying success. Higher rates of successful pain control in persons with CPSP can be achieved by treating other sequelae of stroke, such as depression and spasticity. As the age of the population increases, the diagnosis and management of CPSP will become increasingly important to

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Muscles with severe impairment are likely to be more limited in their ability to exercise and may require help to do this. They may require additional interventions, to manage the greater neurological impairment and also the greater secondary complications. These interventions may include serial

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Another group of researchers concluded that while spasticity may contribute to significant motor and activity impairments post-stroke, the role of spasticity has been overemphasized in stroke rehabilitation. In a survey done by the National Stroke Association, while 58 percent of survivors in the

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MSC treatment also has shown to have various neuroprotective effects, including reductions in apoptosis, inflammation and demyelination, as well as increased astrocyte survival rates. MSC treatment also appears to improve the control of cerebral blood flow and blood–brain barrier permeability, as

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In stroke patients, we found a moderate quality of evidence that MT as an additional therapy improves recovery of arm function after stroke. The quality of evidence regarding the effects of MT on the recovery of lower limb functions is still low, with only one study reporting effects. In patients

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The initial severity of impairments and individual characteristics, such as motivation, social support, and learning ability, are key predictors of stroke recovery outcomes. Responses to treatment and overall recovery of function are highly dependent on the individual. Current evidence indicates

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The current body of evidence is uncertain whether the use of rehabilitation can improve on-road driving skills following stroke. There is limited evidence that training on a driving simulator will improve performance on recognizing road signs after training. The findings are based on low-quality

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and the pain associated with subluxation. Different slings are available to manage shoulder subluxation. However, the use of slings remains controversial and may increase the risk of adverse effects on symmetry and balance between the left and right shoulders, and can impact peoples' body image.

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Robot-assisted training enables stroke patients with moderate or severe upper limb impairment to perform repetitive tasks in a highly consistent manner, tailored to their motor abilities. High intensity repetitive task practice delivered via robot-assisted therapy is recommended to improve motor

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and brain imaging studies have demonstrated that the brain undergoes plastic changes in function and structure in patients that perform constraint induced movement therapy. These changes accompany the gains in motor function of the paretic upper limb. However, there is no established causal link

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The current body of evidence is uncertain on the efficacy of cognitive rehabilitation for reducing the disabling effects of neglect and increasing independence remains unproven. However, there is limited evidence that cognitive rehabilitation may have an immediate beneficial effect on tests of

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The current body of scientific evidence is uncertain on the effectiveness of cognitive rehabilitation for attention deficits in patients following stroke. While there may be an immediate effect after treatment on attention, the findings are based on low to moderate quality and small number of

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The latest evidence supports the short-term benefits of motor imagery (MI) on walking speed in individuals who have had a stroke, in comparison to other therapies. MI does not improve motor function after stroke and does not seem to cause significant adverse events. The findings are based on

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Based on low quality evidence, it is currently uncertain whether yoga has a significant benefit for stroke rehabilitation on measures of quality of life, balance, strength, endurance, pain, and disability scores. Yoga may reduce anxiety and could be included as part of patient-centred stroke

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is controversial. However, physiotherapy can help to improve motor performance, in part, through the management of spasticity. Repetitive task training (RTT), which involves the active practice of task-specific motor activities, improves upper and lower limb function, with improvements being

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and motor learning. Task practice is a component of a broad approach to treatment that includes in-depth assessment of the movement strategies utilized by the patient to perform tasks, and identification of specific deficits of neurological and neuromuscular functions. Many studies have been

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has recently been called into question after studies of transplanted haematopoietic stem cells showed the development of myoblasts, endothelium, epithelium and neuroectodermal cells, suggesting pluripotency. These findings have led to MSCs being considered for treatment of ischemic stroke,

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The incidence of post-stroke depression peaks at 3–6 months and usually resolves within 1–2 years after the stroke, although a minority of patients can go on to develop chronic depression. The diagnosis of post-stroke depression is complicated by other consequences of stroke such as

895:. Use of a sling can also contribute to learned nonuse by preventing the functional and spontaneous use of the affected upper extremity. That said, a sling may be necessary for some therapy activities. Slings may be considered appropriate during therapy for initial transfer and 1091:. The prognosis for someone with lateral medullary syndrome depends upon the size and location of damaged area of the brain stem. Some individuals recover quickly while others may have significant neurological disabilities for months to years after the initial injury. 964:

is beneficial in improving upper limb and hand function in patients with stroke. Thus, action observation therapy is generally associated with better arm and hand function, with no significant adverse events. The findings are based on low to moderate quality evidence.

418:(formation of new synapses between neurons) has been shown to increase after MSC treatment; this combination of improved neurogenesis, angiogenesis and synaptogenesis may lead to a more significant functional improvement in damaged areas as a result of MSC treatment. 457:

from reticulospinal and other descending pathways to the motor and interneuronal circuits of the spinal cord, and the absence of an intact corticospinal system. In other words, there is damage to the part of the brain or spinal cord that controls voluntary movement.

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Various means are available for the treatment of the effects of the upper motor neuron syndrome. These include: exercises to improve strength, control and endurance, nonpharmacologic therapies, oral drug therapy, intrathecal drug therapy, injections, and surgery.

233:. He did the same experiment without binding the arms, and waited six months past their injury. The monkeys without the intervention were not able to use the affected arm even six months later. In 1918, this study was published, but it received little attention. 521:

may develop and become quite severe before it begins to decline (if it does at all). Although an overall pattern of motor recovery exists, there is much variability between each individual's recovery. As previously described, the role of spasticity in stroke

846:, or weakness of the musculature of the upper limb. Traditionally this has been thought to be a significant cause of post-stroke shoulder pain, although a few recent studies have failed to show a direct correlation between shoulder subluxation and pain. 909:(FES) has also shown promising results in treatment of subluxation, and reduction of pain, although some studies have shown a return of pain after discontinuation of FES. More recent research has failed to show any reduction of pain with the use of FES. 3239:

Lee J, Kuroda S, Shichinohe H, Ikeda J, Seki T, Hida K, et al. (September 2003). "Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice".

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Treatment should be based on assessment by the relevant health professionals, although there is evidence that caregivers utilise social media communities to source information related to stroke recovery. For muscles with mild-to-moderate impairment,

689:, can be difficult to assess due to the fact that the pain can change daily in description and location, and can appear anywhere from months to years after the stroke. CPSP can also lead to a heightened central response to painful sensations, or 447:

Muscles affected by the upper motor neuron syndrome have many potential features of altered performance including: weakness, decreased motor control, clonus (a series of involuntary rapid muscle contractions), exaggerated deep tendon reflexes,

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and that <1% of injected MSCs become truly differentiated and integrate in the damaged area. This suggests that transdifferentiation of MSCs into neurons or neuron-like cells is not a major mechanism by which MSCs cause neurorestoration.

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Standardized assessments are also performed to aid in the development of an appropriate care plan. Current research suggests that stroke units may be effective in reducing in-hospital fatality rates and the length of hospital stays.

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casting, flexibility exercise such as sustained positioning programs, and patients may require equipment, such as using a standing frame to sustain a standing position. Applying specially made Lycra garments may also be beneficial.

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Koyuncu E, Nakipoğlu-Yüzer GF, Doğan A, Ozgirgin N (2010). "The effectiveness of functional electrical stimulation for the treatment of shoulder subluxation and shoulder pain in hemiplegic patients: A randomized controlled trial".

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Borlongan CV, Lind JG, Dillon-Carter O, Yu G, Hadman M, Cheng C, et al. (May 2004). "Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier".

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began prescription of therapeutic exercises for stroke patient with good results. At that point, a good outcome was considered to be achieving a level of independence in which patients are able to transfer from the bed to the

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well as what is currently thought to be the most important mechanism of MSC treatment after stroke, the activation of endogenous neuroprotection and neurorestoration pathways by the release of cytokines and trophic factors.

767:. Overall, the shoulder is very mobile, and relies on muscles and ligaments to support it, therefore, if a stroke damages the neurons that control those muscles and ligaments, the joint can be affected and pain may result. 229:. He then bound up the monkey's good arm, and forced the monkey to use his bad arm, and observed what happened. After two weeks of this therapy, the monkeys were able to use their once hemiplegic arms again. This is due to 452:

and decreased endurance. The term "spasticity" is often erroneously used interchangeably with upper motor neuron syndrome, and it is not unusual to see patients labeled as spastic who demonstrate an array of UMN findings.

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Blake J, Mitchell B, McKay S, Uswatte G, Taub E (November 2020). "Development of the Transfer Package for Constraint Induced Cognitive Training: Transferring Cognitive Improvements from the Laboratory to the Real World".

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Pedersen PM, Jørgensen HS, Kammersgaard LP, Nakayama H, Raaschou HO, Olsen TS (September 2001). "Manual and oral apraxia in acute stroke, frequency and influence on functional outcome: The Copenhagen Stroke Study".

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Lobo, Elton H.; Johnson, Tara; Frølich, Anne; Kensing, Finn; Rasmussen, Lene J.; Hosking, Sarah M.; Page, Amy T.; Livingston, Patricia M.; Islam, Sheikh Mohammed Shariful; Grundy, John; Abdelrazek, Mohamed (2022).

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Mayberg HS, Robinson RG, Wong DF, Parikh R, Bolduc P, Starkstein SE, et al. (August 1988). "PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression".

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Overall, the development of post-stroke depression can play a significant role in a patient's recovery from a stroke. The severity of post-stroke depression has been associated with severity of impairment in

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The first studies to look for an association between specific stroke lesions and the occurrence of depression reported a correlation between left frontal lesions and major depression. Damage to the frontal

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Li Y, Chen J, Zhang CL, Zhang CL, Wang L, Lu D, Katakowski M, Gao Q, Shen LH, Zhang J, Lu M, Chopp M (2005). "Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells".

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Electromechanical and robot-assisted arm training may improve arm function (measured using the 'arm function outcome measure') and may significantly improve activities of daily living (ADL) scores.

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structures and possibly early re-activation of shoulder musculature using functional electrical stimulation. Aggressive exercises such as overhead pulleys should be avoided with this population.

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not experience any improvements in their everyday functioning. For this reason, scientific teams have been trying to develop a reliable transfer package that could be used to train and improve

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Zhang J, Li Y, Chen J, Yang M, Katakowski M, Lu M, Chopp M (December 2004). "Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells".

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and posterior deltoid become flaccid and can no longer offer adequate support leading to a downward and outward movement of arm at the shoulder joint causing tension on the relatively weak

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happens in the first three months, and only minor recovery occurs after six months. More recent research has demonstrated that significant improvement can be made years after the stroke.

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Yano S, Kuroda S, Shichinohe H, Hida K, Iwasaki Y (December 2005). "Do bone marrow stromal cells proliferate after transplantation into mice cerebral infarct?--a double labeling study".

414:(development of new blood vessels) by MSCs has been associated with improvements in brain function after ischemic strokes and is linked to improved neuronal recruitment. In addition, 225:

The idea for constraint-induced therapy is at least 100 years old. Significant research was carried out by Robert Oden. He was able to simulate a stroke in a monkey's brain, causing

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Gracies JM, Fitzpatrick R, Wilson L, Burke D, Gandevia SC (October 1997). "Lycra garments designed for patients with upper limb spasticity: mechanical effects in normal subjects".

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Sütbeyaz S, Yavuzer G, Sezer N, Koseoglu BF (May 2007). "Mirror therapy enhances lower-extremity motor recovery and motor functioning after stroke: a randomized controlled trial".

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Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, et al. (August 2000). "Adult bone marrow stromal cells differentiate into neural cells in vitro".

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Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M (2006). "Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke".

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There are several non-pharmacological interventions which are recommended for prevention and treatment of post-stroke hemiplegic shoulder pain. These include proper positioning,

3740:"Nitric oxide donor upregulation of stromal cell-derived factor-1/chemokine (CXC motif) receptor 4 enhances bone marrow stromal cell migration into ischemic brain after stroke" 2467: 563:

decrease the extent of spasticity. The focus of physiotherapy for post-stroke individuals is to improve motor performance, in part, through the manipulation of muscle tone.

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Pollock A, Hazelton C, Henderson CA, Angilley J, Dhillon B, Langhorne P, et al. (March 2012). "Interventions for age-related visual problems in patients with stroke".

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Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, et al. (December 2002). "Ischemic rat brain extracts induce human marrow stromal cell growth factor production".

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Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G, Mavilio F (March 1998). "Muscle regeneration by bone marrow-derived myogenic progenitors".

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Brandstater ME (1998). "Stroke Rehabilitation". In DeLisa JA, Gans BM, Bockenek WL, Currie DM, Geiringer SR, Gerber LH, Leonard JA, McPhee MC, Pease WS, Walsh NE (eds.).

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Rothgangel AS, Braun SM, Beurskens AJ, Seitz RJ, Wade DT (March 2011). "The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature".

709:. Both the variation and mechanism of pain in CPSP have made it difficult to treat. Several strategies have been employed by physicians, including intravenous lidocaine, 2903:

Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR (December 2000). "Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow".

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are encouraged to use verbal communication. Therapy is typically carried out in groups and barriers are used so hands, and any compensatory strategies are not seen.

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Li Y, Chen J, Chopp M (January 2002). "Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats".

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Longley, Verity; Hazelton, Christine; Heal, Calvin; Pollock, Alex; Woodward-Nutt, Kate; Mitchell, Claire; Pobric, Gorana; Vail, Andy; Bowen, Audrey (1 July 2021).

2264:"Guidelines for Adult Stroke Rehabilitation and Recovery: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association" 464:

While Landau suggests that researchers do not believe that treating spasticity is worthwhile, many scholars and clinicians continue to attempt to manage/treat it.

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Lagalla G, Danni M, Reiter F, Ceravolo MG, Provinciali L (2000). "Post-stroke spasticity management with repeated botulinum toxin injections in the upper limb".

685:. Now known as CPSP, it is characterized by perceived pain from non-painful stimuli, such as temperature and light touch. This altered perception of stimuli, or 1146:– which do not necessarily indicate the presence of depression. Loss of interest in activities and relationships should prompt an evaluation for depression. 2352:

Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. (April 1999). "Multilineage potential of adult human mesenchymal stem cells".

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individuals to progress through the stages of motor recovery. These stages were originally described by Twitchell and Brunnstrom, and may be known as the

1698:"Use of occupations and activities in a modified constraint-induced movement therapy program: a musician's triumphs over chronic hemiparesis from stroke" 739:

Hemiplegic shoulder pain (shoulder pain on the stroke-affected side of the body) is a common source of pain and dysfunction following stroke. The cause (

5690:"Dysphagia in lateral medullary infarction (Wallenberg's syndrome): an acute disconnection syndrome in premotor neurons related to swallowing activity?" 4893:

Arya KN, Pandian S, Puri V (January 2018). "Rehabilitation methods for reducing shoulder subluxation in post-stroke hemiparesis: a systematic review".

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Martin L, Baker R, Harvey A (November 2010). "A systematic review of common physiotherapy interventions in school-aged children with cerebral palsy".

2789:"Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains" 398:

and these cells respond to common central nervous system neurotransmitters. However, it is unlikely that this degree of transdifferentiation occurs

2647:"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization" 1739:"The effect of modified constraint-induced movement therapy on spasticity and motor function of the affected arm in patients with chronic stroke" 656:

Surgical treatment for spasticity includes lengthening or releasing of muscle and tendons, procedures involving bones, and also selective dorsal

517:. As recovery begins, and progresses, basic movement synergies will develop into more complex and difficult movement combinations. Concurrently, 2305:"Electromechanical and robot-assisted arm training for improving activities of daily living, arm function, and arm muscle strength after stroke" 983:

low-quality evidence as further research is needed to estimate the effect of MI on walking endurance and the dependence on personal assistance.

673:

will develop central post-stroke pain, and that the pain will be moderate to severe in 5% of those affected. The condition was formerly called "

2594:

Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. (April 2001). "Bone marrow cells regenerate infarcted myocardium".

1035:. Signs and symptoms include decreased pain and temperature on the same side of the face and opposite side of the body compared to the lesion, 648:). Many studies have shown the benefits of BTX and it has also been demonstrated that repeat injections of BTX show unchanged effectiveness. 1830: 1528:"Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial" 1323:

On behalf of the Canadian Stroke Strategy Best Practices and Standards Writing Group. 2010; Ottawa, Ontario Canada: Canadian Stroke Network.

5190:

Borges, Lorenna Rdm; Fernandes, Aline Bgs; Oliveira Dos Passos, Jacilda; Rego, Isabelle Ananda Oliveira; Campos, Tania F. (5 August 2022).

842:

of the shoulder joint that typically results from changes in the mechanical integrity of the joint. Subluxation is a common problem with

903:

and voluntary movement of the shoulder will occur as well as reduction in the shoulder subluxation. Slings are of no value at this point.

150:, patients are encouraged to participate in secondary prevention programs for stroke. Follow-up is usually facilitated by the patient's 4161:"Utilization of social media communities for caregiver information support in stroke recovery: An analysis of content and interactions" 1232:"Part 11: adult stroke: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care" 542:

and dressing, whereas in the leg, abnormal resting postures may result in difficulty transferring. In order to help manage spasticity,

3192:"Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat" 2849:

Brazelton TR, Rossi FM, Keshet GI, Blau HM (December 2000). "From marrow to brain: expression of neuronal phenotypes in adult mice".

870:. Other factors have also been cited as contributing to subluxation such as pulling on the hemiplegic arm and improper positioning. 322: 177:

For most of the last century, people were discouraged from being active after a stroke. Around the 1950s, this attitude changed, and

5640:

Nickerson RB, Atchison JW, Van Hoose JD, Hayes D (March 1997). "Hiccups associated with lateral medullary syndrome. A case report".

4834: 4722: 1158: 5028:"Non-pharmacological interventions for spatial neglect or inattention following stroke and other non-progressive brain injury" 5678: 4306: 1932: 170:, by studying the brain of a pig, developed the theory that stroke was caused by an interruption of the flow of blood to the 17: 1028: 974:

studies. Further research is needed to assess whether the effect can be sustained in day-to-day tasks requiring attention.

439:, it may also be important to address any possible ethical concerns (however unlikely) over the use of somatic stem cells. 5378: 3925:

Watkins CL, Leathley MJ, Gregson JM, Moore AP, Smith TL, Sharma AK (August 2002). "Prevalence of spasticity post stroke".

791:

injections into the shoulder muscles has also been shown to provide significant pain relief and improve range of motion.

640:. Phenol and alcohol cause local muscle damage by denaturing protein, and thus relaxing the muscle. Botulinum toxin is a 429: 290:(FES) is commonly used in 'foot-drop' following stroke, but it can be used to help retrain movement in the arms or legs. 237: 220: 4723:"Hemiplegic Shoulder Pain & Complex Regional Pain Syndrome | EBRSR - Evidence-Based Review of Stroke Rehabilitation" 2022:

Dickstein R, Hocherman S, Pillar T, Shaham R (August 1986). "Stroke rehabilitation. Three exercise therapy approaches".

4514: 4465:

French B, Thomas LH, Coupe J, McMahon NE, Connell L, Harrison J, et al. (Cochrane Stroke Group) (November 2016).

5820: 4869: 4703: 4549: 4026: 1620: 1110: 906: 798:

injections can be effective for people with shoulder pain related to injury/inflammation of the rotator cuff region.

287: 253:

between observed changes in brain function/structure and the motor gains due to constraint induced movement therapy.

249: 558:. In addition, the passive manual technique of rhythmic rotation can help to increase initial range. Activating the 6064: 3830:

Ivanhoe CB, Reistetter TA (October 2004). "Spasticity: the misunderstood part of the upper motor neuron syndrome".

3002:

Dharmasaroja P (January 2009). "Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke".

5302:

Silva S, Borges LR, Santiago L, Lucena L, Lindquist AR, Ribeiro T (September 2020). Cochrane Stroke Group (ed.).

4132: 211:

by Carlo Perfetti concept", widespread in many countries, is an original motor re-learning theories application.

132: 5903:

Robinson RG (August 2003). "Poststroke depression: prevalence, diagnosis, treatment, and disease progression".

4322:

Pollock A, Baer G, Campbell P, Choo PL, Forster A, Morris J, et al. (Cochrane Stroke Group) (April 2014).

3047:"Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype" 952:

rehabilitation. Further research is needed assessing the benefits and safety of yoga in stroke rehabilitation.

764: 364: 1897: 6079: 6069: 4608:

Andersen G, Vestergaard K, Ingeman-Nielsen M, Jensen TS (May 1995). "Incidence of central post-stroke pain".

4004:

Mayer et al. (September 2002) "Spasticity: Etiology, Evaluation, Management and the Role of Botulinum Toxin"

208: 1083:. There are case reports of other medications useful in treating hiccups in Wallenberg's Syndrome including 1572:"Constraint-induced movement therapy following stroke: a systematic review of randomised controlled trials" 1174: 815: 1644:

Corbetta D, Sirtori V, Castellini G, Moja L, Gatti R, et al. (Cochrane Stroke Group) (October 2015).

4980:

Kumar R, Metter EJ, Mehta AJ, Chew T (August 1990). "Shoulder pain in hemiplegia. The role of exercise".

4093:"Spasticity after stroke: its occurrence and association with motor impairments and activity limitations" 2403:

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, et al. (July 2002).

1786:

Wittenberg GF, Schaechter JD (December 2009). "The neural basis of constraint-induced movement therapy".

6031: 1206:

is done on pharmacotherapy and its potential benefits for patients with cognitive decline after stroke.

5515:"Cognitive impairment and memory dysfunction after a stroke diagnosis: a post-stroke memory assessment" 4789:"Canadian stroke best practice recommendations: Stroke rehabilitation practice guidelines, update 2015" 1211: 1190: 1024: 1019: 245: 140: 430:

What this means for stroke patients and the limitations or concerns with MSCs as a potential treatment

6074: 1150: 269: 4833:

Roy MA, Korner-Bitensky N, Teasell R, Foley N, Bhogal S, Bitensky J, Speechley M (29 October 2010).

628:

Injections are focal treatments administered directly into the spastic muscle. Drugs used include:

481:

should be the mainstay of management, and is likely to need to be prescribed by a physiotherapist.

389: 244:

technique at varying stages of stroke recovery to improve upper limb motor function and use during

62: 468:

survey experienced spasticity, only 51 percent of those had received treatment for the condition.

236:

Eventually, researchers began to apply his technique to stroke patients, and it came to be called

1143: 855: 2118:

Kollen BJ, Lennon S, Lyons B, Wheatley-Smith L, Scheper M, Buurke JH, et al. (April 2009).

1834: 4324:"Physical rehabilitation approaches for the recovery of function and mobility following stroke" 3571:"Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury" 1437:

Twitchell TE (December 1951). "The restoration of motor function following hemiplegia in man".

1276:

Duncan PW, Zorowitz R, Bates B, Choi JY, Glasberg JJ, Graham GD, et al. (September 2005).

1100: 934:

neglect. Overall, no rehabilitation approach can be supported by evidence for spatial neglect.

839: 674: 527:

sustained 6-months post-treatment. More research is needed on the type and amount of training.

346: 305: 128: 158:

that most significant recovery gains will occur within the first 12 weeks following a stroke.

3328:"Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia" 2735:

Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, et al. (May 2001).

1738: 1055:

can be present and limit progress in rehabilitation and recovery. Symptomatic treatment with

5138:

Lawrence M, Celestino Junior FT, Matozinho HH, Govan L, Booth J, Beecher J (December 2017).

394:

Transdifferentiation of MSCs into excitable neuron-like cells has been shown to be possible

365:

Use of bone-marrow derived mesenchymal stem cells (MSCs) in the treatment of ischemic stroke

4172: 2912: 2858: 2800: 2645:

Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, et al. (August 1999).

2603: 2511: 2416: 2361: 1526:

Wolf SL, Winstein CJ, Miller JP, Taub E, Uswatte G, Morris D, et al. (November 2006).

1040: 863: 851: 760: 436: 5840:"Mesial temporal cortex hypoperfusion is associated with depression in subcortical stroke" 1230:

Jauch EC, Cucchiara B, Adeoye O, Meurer W, Brice J, Chan YY, et al. (November 2010).

961: 8: 5978:"Mirror therapy promotes recovery from severe hemiparesis: a randomized controlled trial" 2545:

Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, et al. (June 2001).

2120:"The effectiveness of the Bobath concept in stroke rehabilitation: what is the evidence?" 559: 510: 383: 374:

specifically in directly enhancing neuroprotection and the neurorestorative processes of

178: 167: 5609: 5481: 4787:

Hebert D, Lindsay MP, McIntyre A, Kirton A, Rumney PG, Bagg S, et al. (June 2016).

4176: 2916: 2862: 2804: 2607: 2515: 2420: 2365: 2262:

Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, et al. (June 2016).

1333:

Zhu HF, Newcommon NN, Cooper ME, Green TL, Seal B, Klein G, et al. (January 2009).

660:. Rhizotomy, usually reserved for severe spasticity, involves cutting selective sensory 488: 5928: 5794: 5777: 5751: 5726: 5582: 5541: 5514: 5490: 5465: 5443: 5328: 5303: 5276: 5251: 5224: 5191: 5164: 5139: 5112: 5087: 5060: 5027: 5005: 4962: 4918: 4676: 4633: 4491: 4466: 4348: 4323: 4195: 4160: 4109: 4092: 4068: 4051: 3950: 3855: 3843: 3812: 3764: 3739: 3720: 3636: 3551: 3500: 3473: 3454: 3405: 3393: 3352: 3327: 3308: 3265: 3221: 3167: 3124: 3027: 2979: 2936: 2882: 2766: 2627: 2484: 2476: 2440: 2385: 2329: 2304: 2229: 2091: 1995: 1811: 1763: 1670: 1645: 1378: 1294: 1277: 1032: 831: 783:) may offer some pain relief for generalized hemiplegic shoulder pain. For people with 748: 124: 5916: 5838:

Grasso MG, Pantano P, Ricci M, Intiso DF, Pace A, Padovani A, et al. (May 1994).

4231: 3441: 3425:"Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain" 3424: 3155: 2753: 2736: 2712: 2687: 2571: 2547:"Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells" 2546: 1924: 1588: 1571: 1248: 1231: 5999: 5964: 5920: 5891: 5861: 5826: 5816: 5799: 5756: 5711: 5674: 5657: 5653: 5613: 5586: 5546: 5495: 5435: 5431: 5333: 5281: 5229: 5211: 5169: 5117: 5065: 5047: 4997: 4993: 4954: 4910: 4875: 4865: 4810: 4766: 4699: 4668: 4625: 4621: 4590: 4586: 4555: 4545: 4496: 4447: 4399: 4353: 4302: 4266: 4235: 4200: 4114: 4073: 4032: 4022: 3942: 3907: 3847: 3804: 3769: 3712: 3677: 3628: 3592: 3543: 3505: 3446: 3397: 3357: 3326:

Liu H, Honmou O, Harada K, Nakamura K, Houkin K, Hamada H, Kocsis JD (October 2006).

3300: 3257: 3253: 3213: 3159: 3116: 3112: 3078: 3019: 2971: 2928: 2874: 2828: 2823: 2788: 2758: 2717: 2668: 2619: 2576: 2527: 2459: 2432: 2404: 2377: 2334: 2285: 2221: 2186: 2151: 2083: 2039: 1999: 1987: 1946: 1938: 1928: 1879: 1803: 1768: 1719: 1675: 1626: 1616: 1593: 1549: 1512: 1477: 1454: 1412: 1356: 1319:

Lindsay MP, Gubitz G, Bayley M, Hill MD, Davies-Schinkel C, Singh S, and Phillips S.

1299: 1253: 1139: 1108:

is a commonly reported consequence of stroke and is seen in 25–50% of patients. The

1105: 888: 792: 478: 370: 50: 5447: 5351:

van Heugten CM (May 2001). "Rehabilitation and Management of Apraxia After Stroke".

5009: 4922: 4680: 4637: 3954: 3859: 3816: 3724: 3656:"Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke" 3640: 3555: 3409: 3312: 3269: 3225: 3171: 3045:

Wislet-Gendebien S, Hans G, Leprince P, Rigo JM, Moonen G, Rogister B (March 2005).

3031: 2940: 2886: 2770: 2444: 2389: 2233: 2095: 1815: 743:) of hemiplegic shoulder pain remains unclear. Possible causes may include shoulder 68: 5989: 5956: 5932: 5912: 5883: 5851: 5789: 5746: 5738: 5701: 5649: 5605: 5574: 5536: 5526: 5485: 5477: 5427: 5360: 5323: 5319: 5315: 5271: 5267: 5263: 5219: 5207: 5203: 5159: 5155: 5151: 5107: 5103: 5099: 5055: 5043: 5039: 4989: 4966: 4946: 4902: 4800: 4756: 4660: 4617: 4582: 4486: 4482: 4478: 4437: 4389: 4343: 4339: 4335: 4262: 4258: 4227: 4190: 4180: 4104: 4063: 3934: 3897: 3839: 3796: 3759: 3751: 3708: 3704: 3667: 3624: 3620: 3582: 3535: 3495: 3485: 3458: 3436: 3389: 3347: 3339: 3296: 3292: 3249: 3203: 3151: 3128: 3108: 3068: 3058: 3011: 2983: 2963: 2920: 2866: 2818: 2808: 2748: 2707: 2699: 2658: 2631: 2611: 2566: 2558: 2519: 2451: 2424: 2369: 2324: 2320: 2316: 2275: 2213: 2178: 2141: 2131: 2075: 2031: 1979: 1920: 1869: 1795: 1758: 1750: 1709: 1665: 1661: 1657: 1583: 1539: 1508: 1497:"Systematic Therapeutic Exercises in the Management of the Paralyses in Hemiplegia" 1446: 1346: 1289: 1243: 1068: 1002: 698: 613: 551: 534:

will result in the maintenance of abnormal resting limb postures which can lead to

523: 5688:

Aydogdu I, Ertekin C, Tarlaci S, Turman B, Kiylioglu N, Secil Y (September 2001).

4906: 3800: 3738:

Cui X, Chen J, Zacharek A, Li Y, Roberts C, Kapke A, et al. (November 2007).

2924: 2870: 2737:"Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell" 2523: 1335:"Impact of a stroke unit on length of hospital stay and in-hospital case fatality" 1059:

and medications for the hiccups are important. Commonly used anti-emetics include

442: 82: 4664: 4651:

Nicholson BD (March 2004). "Evaluation and treatment of central pain syndromes".

4185: 2373: 2280: 2263: 2217: 2136: 2119: 2079: 1799: 1646:"Constraint-induced movement therapy for upper extremities in people with stroke" 1351: 1334: 1157:, have been used in the treatment of post-stroke depression. More recently, the 1088: 913: 807: 788: 718: 714: 706: 682: 629: 494:

research in this area is needed as current body of evidence is very low quality.

230: 3755: 3190:

Chen J, Li Y, Katakowski M, Chen X, Wang L, Lu D, et al. (September 2003).

3063: 3038: 1915:

Brown JA (2006). "Recovery of motor function after stroke". In Møller AR (ed.).

1169:, have become the pharmacologic therapy of choice due to the lower incidence of 943:

evidence as further research is needed involving large numbers of participants.

390:

Possible mechanisms of neurorestoration and neuroprotection by MSCs after stroke

5578: 5386: 4091:

Sommerfeld DK, Eek EU, Svensson AK, Holmqvist LW, von Arbin MH (January 2004).

3654:

Shen LH, Li Y, Chen J, Zacharek A, Gao Q, Kapke A, et al. (January 2007).

3490: 3015: 2793:

Proceedings of the National Academy of Sciences of the United States of America

2688:"Origins of circulating endothelial cells and endothelial outgrowth from blood" 2455: 2182: 1476:. Collana di riabilitazione medica (in Italian). Vol. 7. Milano: Ghedini. 1278:"Management of Adult Stroke Rehabilitation Care: a clinical practice guideline" 1182: 1170: 1080: 1064: 859: 795: 415: 333: 309: 299: 6043: 6019: 5364: 4950: 3980: 3938: 620:

have been used as well, mainly for severe pain as a result of the spasticity.

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Flor H, Diers M (2009). "Sensorimotor training and cortical reorganization".

5830: 5215: 5051: 4879: 4805: 4788: 4559: 4442: 4425: 4378:"Motor testing procedures in hemiplegia: based on sequential recovery stages" 3672: 3655: 2947: 2813: 1983: 1942: 1630: 1544: 1527: 1481: 1450: 1416: 1178: 1154: 1131: 1119: 896: 867: 645: 609: 543: 502: 317: 5856: 5839: 4036: 3902: 3885: 2844: 2842: 2663: 2646: 2035: 1754: 1714: 1697: 6003: 5968: 5924: 5803: 5760: 5715: 5617: 5550: 5499: 5466:"Post-stroke cognitive impairment: epidemiology, mechanisms and management" 5439: 5337: 5285: 5233: 5173: 5121: 5069: 4958: 4914: 4814: 4770: 4672: 4594: 4500: 4451: 4394: 4377: 4357: 4270: 4204: 4118: 4077: 3946: 3911: 3851: 3808: 3773: 3716: 3681: 3632: 3596: 3587: 3570: 3547: 3509: 3474:"Neurorestorative treatment of stroke: cell and pharmacological approaches" 3450: 3401: 3361: 3343: 3304: 3261: 3217: 3163: 3120: 3082: 3023: 2975: 2967: 2932: 2878: 2832: 2762: 2721: 2672: 2623: 2580: 2463: 2436: 2381: 2338: 2289: 2225: 2190: 2155: 2087: 1991: 1950: 1883: 1807: 1772: 1723: 1679: 1597: 1553: 1458: 1360: 1303: 1257: 1123: 1072: 756: 722: 644:

and it relaxes the muscle by preventing the release of a neurotransmitter (

539: 411: 407: 379: 375: 151: 136: 5960: 5895: 5887: 5865: 5706: 5689: 5661: 5001: 4629: 4403: 4239: 3416: 2531: 2473:. If this is an intentional citation to a retracted paper, please replace 2043: 92: 3603: 3046: 2839: 2345: 1874: 1857: 1610: 1060: 1056: 917: 835: 819: 780: 744: 726:

improve the quality of life of an increasing number of stroke survivors.

690: 661: 596: 547: 535: 286:

improve function and aid in retraining weak muscles and normal movement.

76: 5776:

Berg A, Palomäki H, Lehtihalmes M, Lönnqvist J, Kaste M (January 2003).

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Guo HJ, Sapra A (March 2020). "Instrumental Activity of Daily Living.".

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In patients undergoing rehabilitation with a stroke population or other

256:

Constraint induced movement therapy has recently been modified to treat

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Canadian Best Practice Recommendations for Stroke Care (Update 2010).

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Interventions for age-related visual problems in patients with stroke

116: 55: 5815:(3rd ed.). Philadelphia: Lippincott-Raven. pp. 1165–1189. 3368: 3276: 3089: 2953: 2703: 1496: 1027:, also known as Wallenberg's syndrome, is caused by blockage of the 997:

An uncommon, less understood result of stroke is a condition called

5727:"Validation of a dysphagia screening tool in acute stroke patients" 4935: 3731: 3319: 3232: 3135: 2679: 1084: 879: 811: 740: 702: 694: 678: 617: 580: 572: 395: 174:. After that, the focus became how to treat patients with stroke. 5252:"Cognitive rehabilitation for attention deficits following stroke" 4301:(5th ed.). Philadelphia: F.A. Davis Company. pp. 744–5. 2405:"Pluripotency of mesenchymal stem cells derived from adult marrow" 2303:

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Cognitive rehabilitation for attention deficits following stroke

912:

Logical treatment consists of preventive measures such as early

677:", because of the high incidence among those with damage to the 321:

conducted comparing NDT with other treatment techniques such as

5976:

Dohle C, Püllen J, Nakaten A, Küst J, Rietz C, Karbe H (2009).

5639: 5192:"Action observation for upper limb rehabilitation after stroke" 4515:"Rehabilitation Gloves and Dynamic Splints For Stroke Recovery" 2117: 1048: 1036: 633: 571:

Oral medications used for the treatment of spasticity include:

506: 443:

Training of muscles affected by the upper motor neuron syndrome

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Occupational therapy practice framework: domain & process

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Action observation for upper limb rehabilitation after stroke

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Cognitive rehabilitation for spatial neglect following stroke

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Rehabilitation for improving automobile driving after stroke

554:, along with elongation of the spastic muscle and sustained 5724: 5687: 5513:

Al-Qazzaz NK, Ali SH, Ahmad SA, Islam S, Mohamad K (2014).

5400: 5249: 4745:"Post stroke pain: identification, assessment, and therapy" 3924: 2644: 1386:

Evidence Based Review of Stroke Rehabilitation (Version 13)

5642: