49:
376:), and his studies on how these and additional DNA repair factors interact with and influence one another, often in ways regulated by post-translational modifications. Jackson's work has also helped establish how DSB repair is controlled during the cell cycle, at telomeres in response to cell aging/senescence, and within chromatin.
467:
for
Science 2016, in recognition of his "outstanding contribution to defining the link between the basic mechanism of genomic DNA instability and its relationship to cancer. Specifically, he unraveled the salient components of the pathway involved in DNA repair. He is also credited with an innovative
479:
for his "fundamental research into DNA repair in human cells and for the successful application of knowledge of that process in the development of new cancer drugs". In 2017 he was awarded the Genome
Stability Network medal for his contributions to the field of genome stability and particularly for
459:
Innovator of the Year Award (2009); the Royal
Society Buchanan Medal (2011), the latter in recognition of his "outstanding contributions to understanding DNA repair and DNA damage response signalling pathways", and the Gagna A. & Ch. Van Heck Prize (2015) for "his cardinal contributions related
483:
The
Fondation ARC's Leopold Griffuel Prize in Translational and Clinical Research was presented to Jackson in 2019 for his work on DNA damage repair and his role in the development of medicines such as PARP1 and 2 inhibitors, currently used for cancer treatment. In 2020, he was awarded the Royal
364:; processes fundamental to life and whose defects cause various diseases particularly cancer. Through his discovery that the DNA-dependent protein kinase (DNA-PK) enzyme is activated by DNA double-strand breaks (DSBs), Jackson's laboratory identified and characterised various components of the
398:
In 2011 Jackson founded MISSION Therapeutics a firm to develop drugs to improve the management of life-threatening diseases, particularly cancer. In 2017, he founded
Adrestia Therapeutics Ltd and currently serves as Chief Scientific Officer.
415:
was found guilty of research fraud. Kaidi additionally confessed that he had made false data in two of his research papers published with
Jackson. Bristol conveyed the matter to the University of Cambridge which took up an investigation.
1588:
495:
honoured Steve with Cancer
Research Horizon's Entrepreneurship Recognition Award in recognition of his longstanding academic entrepreneurship and his outstanding contributions that have enhanced the field of oncology.
539:
215:
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for his research on DNA repair mechanisms and synthetic lethality that led to the discovery of olaparib which has reached blockbuster status for the treatment of ovarian and breast cancers.
491:
In 2022, Jackson was awarded the Johann Anton Merck Award, which is given for outstanding scientific preclinical research accomplishments in the areas of Merck
Healthcare‘s strategic focus.
447:
Jackson has received numerous awards, medals and honorary degrees: the inaugural
Eppendorf-Nature European Young Investigator Award (1995); the Tenovus Medal for Cancer Research (1997); the
383:
pathways into new treatments for cancer. KuDOS developed small-molecule inhibitors of several DNA damage response enzymes. The most advanced of these is the poly (ADP-ribose) polymerase 1 (
1082:
808:
794:
439:(in 2013) contain fabricated data that were done by Kaidi. Jackson was not involved in the misdeed. The two journals simultaneously retracted the papers on 11 April 2019.
2206:
2491:
391:/Lynparza™, which is now a registered medicine worldwide. KuDOS developed into a fully integrated drug-discovery and drug-development company and was acquired by
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368:(NHEJ) system that repairs most DSBs in human cells. These studies also provided a paradigm for Jackson's later work on DNA-damage signalling by the
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Gottlieb TM, Jackson SP (1993). "The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen".
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1440:"University of Glasgow - Colleges - College of Medical, Veterinary & Life Sciences - Tenovus - Previous Medal Winners"
2922:
2897:
2348:
1722:
527:
Who's Who 2014, A & C Black, an imprint of
Bloomsbury Publishing plc, 2014; online edn, Oxford University Press, 2013
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2537:
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198:
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approach to bring his findings into tangible therapeutic products to treat cancer". He was elected a member of the
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1740:
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144:
472:(EMBO) in 1997, a Fellow of the Academy of Medical Sciences in 2001 and a Fellow of the Royal Society in 2008.
1421:
957:
1826:
837:"Acquisition Of KuDOS Pharmaceuticals Will Enhance AstraZeneca's Ability To Generate Novel Cancer Treatments"
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1008:
Kaidi, Abderrahmane; Weinert, Brian T.; Choudhary, Chunaram; Jackson, Stephen P. (10 September 2010).
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353:. He returned to the UK in 1991 as a Junior Group Leader at the then Wellcome-CRC Institute, now the
1439:
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over the article the next month. Cambridge made its final decision in April 2019 that the paper in
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Kaidi, Abderrahmane; Weinert, Brian T.; Choudhary, Chunaram; Jackson, Stephen P. (19 April 2019).
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that the paper published in 2010 was investigated for research misconduct. The journal issued an
326:
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317:, graduating with a Bachelor of Science degree in biochemistry in 1983. He then carried out his
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2004:
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1687:"47e Prix Fondation ARC Léopold Griffuel | Fondation ARC pour la recherche sur le cancer"
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1358:"Retraction Note: KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling"
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1021:
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706:"Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications"
8:
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1373:
1301:"Retraction [Human SIRT6 promotes DNA end resection through CtIP deacetylation]"
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In 1997 Jackson founded KuDOS Pharmaceuticals with the aim of translating knowledge of
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to cellular events that detect, signal the presence of and repair DNA damages".
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Jackson's work has provided key insights into cellular processes that respond to
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1998:
1980:
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1669:"11.02.19 Steve Jackson to receive the ARC Foundation's Léopold Griffuel Award"
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451:(1997); the Anthony Dipple Carcinogenesis Young Investigator award (2002); the
448:
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1010:"RETRACTED: Human SIRT6 promotes DNA end resection through CtIP deacetylation"
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755:"Functional links between telomeres and proteins of the DNA-damage response"
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2027:
1986:
1914:
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1407:
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1215:
1196:
1155:"KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling"
1139:
1078:
1059:
780:
739:
687:
662:"ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response"
600:
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180:
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2715:
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2614:
1633:"10.05.16 Steve Jackson wins the 2016 Dr A.H. Heineken Prize for Medicine"
635:
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2503:
2449:
2182:
2152:
2057:
1956:
1908:
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216:
Cloning and characterisation of the RNA8 gene of Saccharomyces cerevisiae
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232:
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76:
1539:"Gagna A. & Ch. Van Heck Prize awarded to Professor Steve Jackson"
2241:
1805:
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the realisation of the therapeutic potential of targeting the DDR.
388:
265:
1811:
1557:"20.01.16 Steve Jackson wins 2016 King Faisal International Prize"
341:
Following his PhD, Jackson carried out postdoctoral research with
1705:"Steve Jackson 2020 recipient of the Royal Society Mullard Award"
286:
2545:
1240:"Top journals retract DNA-repair studies after misconduct probe"
752:
209:
172:
114:
1661:
1625:
1549:
1530:
1575:"The Academy of Medical Sciences | Directory of Fellows"
958:"Articles pulled after data fabrication in Cambridge DNA lab"
456:
384:
1298:
1007:
809:"LYNPARZA™ approved by the US Food and Drug administration"
1356:
Kaidi, Abderrahmane; Jackson, Stephen P. (11 April 2019).
1802:
Steve Jackson on the power of blue skies research (video)
318:
36:
1495:"Biochemical Society Transactions | Portland Press"
1153:
Kaidi, Abderrahmane; Jackson, Stephen P. (6 June 2013).
795:"PARP inhibitors: Halting cancer by halting DNA repair"
559:"The DNA-damage response in human biology and disease"
349:, where he developed an interest in the regulation of
297:
Cambridge Institute and associate group leader at the
984:"Bristol Uni lecturer resigns after faking research"
932:"Bristol Uni lecturer resigns after faking research"
1643:
905:"Bristol lecturer resigns over fabricated research"
540:"Cloning and characterisation of the RNA8 gene of
419:On 19 August 2018, Cambridge and Jackson informed
2879:
1792:Cancer patient Sandy meets Steve Jackson (video)
1613:. Royal Netherlands Academy of Arts and Sciences
1455:"Sensing and repairing DNA double-strand breaks"
753:D'Adda di Fagagna F, Teo SW, Jackson SP (2004).
659:
407:In 2018, Jackson's former postdoctoral scholar,
861:
839:(press release). AstraZeneca. 23 December 2005.
811:(press release). AstraZeneca. 19 December 2014.
613:
2531:
1827:
1741:"Innovation and Entrepreneurship Awards 2022"
2867:David Sainsbury, Baron Sainsbury of Turville
1355:
1152:
825:. European Medicines Agency. 9 January 2015.
703:
655:
653:
2538:
2524:
1834:
1820:
291:Frederick James Quick Professor of Biology
47:
1470:
1397:
1332:
1186:
1049:
770:
729:
677:
590:
507:for services to innovation and research.
1757:
879:
797:. Cancer Research UK. 24 September 2020.
650:
2928:Fellows of St John's College, Cambridge
1767:(Supplement). 17 June 2023. p. B2.
1567:
1452:
843:
556:
537:
470:European Molecular Biology Organization
14:
2880:
1536:
1422:"European Award - Eppendorf Corporate"
699:
697:
546:(PhD thesis). University of Edinburgh.
374:Ataxia telangiectasia and Rad3 related
2908:Alumni of the University of Edinburgh
2519:
1815:
1520:"Buchanan Medal | Royal Society"
1512:
1233:
1231:
531:
442:
293:. He is a senior group leader at the
1237:
1097:
981:
955:
929:
477:Dr A. H. Heineken Prize for Medicine
402:
150:Dr. A.H. Heineken Prize for Medicine
109:Understanding cellular responses to
1841:
1611:"Heineken Prizes - Stephen Jackson"
1581:
982:Yong, Michael (14 September 2018).
975:
930:Yong, Michael (14 September 2018).
694:
24:
1537:Thomas, Glynn (18 November 2015).
1228:
1098:Berg, Jeremy (28 September 2018).
949:
923:
897:
455:GlaxoSmithKline Award (2008); the
347:University of California, Berkeley
199:University of California, Berkeley
25:
2959:
2903:Alumni of the University of Leeds
1775:
1655:www.genomestabilitynetwork.org.uk
1100:"Editorial expression of concern"
660:Blackford AN, Jackson SP (2017).
538:Jackson, Stephen Phillip (1987).
475:In 2016, Jackson was awarded the
463:Jackson is the co-winner of the
2918:21st-century British biologists
2913:20th-century British biologists
1751:
1733:
1723:"2022 Johann Anton Merck Award"
1715:
1697:
1603:
1501:
1487:
1446:
1432:
1414:
1349:
1292:
1266:
1146:
1091:
1001:
829:
815:
524:‘JACKSON, Prof. Stephen Philip’
465:King Faisal International Prize
145:King Faisal International Prize
801:
787:
746:
607:
550:
517:
13:
1:
2933:Winners of the Heineken Prize
1238:Else, Holly (15 April 2019).
510:
2938:Fellows of the Royal Society
956:Mayo, Nick (12 April 2019).
704:Polo SE, Jackson SP (2011).
679:10.1016/j.molcel.2017.05.015
628:10.1016/0092-8674(93)90057-W
313:Jackson was educated at the
308:
7:
2943:Quick Professors of Biology
1850:Biochemistry and Biophysics
370:ATM serine/threonine kinase
336:
333:, earning his PhD in 1987.
289:(born 17 July 1962) is the
130:Fellow of the Royal Society
10:
2964:
2923:British cancer researchers
2898:Scientists from Nottingham
1782:Meet Steve Jackson (video)
1252:10.1038/d41586-019-00406-4
366:non-homologous end joining
279:Sir Stephen Philip Jackson
2859:
2808:
2561:
2400:
2341:
2234:
2127:
2014:
1849:
1796:Worldwide Cancer Research
1589:"Jackson; Stephen Philip"
1382:10.1038/s41586-019-1142-2
1208:10.1038/s41586-019-1142-2
325:on yeast RNA splicing at
242:
238:
226:
208:
190:
168:
161:
120:
105:
84:
55:
46:
34:
18:Steve Jackson (scientist)
1745:Cancer Research Horizons
1709:Steve Jackson Laboratory
873:Steve Jackson Laboratory
823:"EPAR Medicine Overview"
542:Saccharomyces cerevisiae
1472:10.1093/carcin/23.5.687
1453:Jackson, S. P. (2002).
1426:corporate.eppendorf.com
1317:10.1126/science.aax4558
1124:10.1126/science.aav4528
1071:10.1126/science.aax4558
1034:10.1126/science.1192049
887:"Adrestia Therapeutics"
759:Genes & Development
710:Genes & Development
327:Imperial College London
303:University of Cambridge
203:University of Edinburgh
195:University of Cambridge
113:and their relevance to
99:University of Edinburgh
94:Imperial College London
2147:BirdLife International
2128:Environmental Sciences
962:Times Higher Education
411:, then working at the
321:research working with
155:Leopold Griffuel Prize
60:Stephen Philip Jackson
2676:Christopher John Lamb
1691:www.fondation-arc.org
1508:Innovator of the Year
1202:(Retracted, see
1065:(Retracted, see
891:Adrestia Therapeutics
505:2023 Birthday Honours
427:expression of concern
413:University of Bristol
2821:William A. Catterall
2773:Claudio Daniel Stern
2569:Girish Saran Agarwal
1673:www.gurdon.cam.ac.uk
1637:www.gurdon.cam.ac.uk
1561:www.gurdon.cam.ac.uk
855:Mission Therapeutics
557:Jackson, SP (2009).
331:Edinburgh University
1675:. 11 February 2019.
1651:"News & Events"
1591:. The Royal Society
1374:2019Natur.568..576K
1179:10.1038/nature12201
1171:2013Natur.498...70K
1116:2018Sci...361.1322B
1026:2010Sci...329.1348K
1020:(5997): 1348–1353.
911:. 13 September 2018
772:10.1101/gad.1214504
722:10.1101/gad.2021311
583:10.1038/nature08467
575:2009Natur.461.1071J
569:(7267): 1071–1078.
453:Biochemical Society
381:DNA damage response
315:University of Leeds
89:University of Leeds
2767:Philip J. Stephens
2739:Matthew Rosseinsky
2656:Christopher Hunter
2609:Alexander Bradshaw
2604:Leszek Borysiewicz
1764:The London Gazette
1747:. 9 December 2022.
1563:. 20 January 2016.
493:Cancer Research UK
443:Honours and awards
409:Abderrahmane Kaidi
295:Cancer Research UK
2875:
2874:
2816:J. Michael Bishop
2636:Russell G. Foster
2513:
2512:
2342:Cognitive Science
1274:"Two Retractions"
765:(15): 1781–1799.
403:Paper retractions
276:
275:
185:Molecular biology
163:Scientific career
27:British biologist
16:(Redirected from
2955:
2948:Knights Bachelor
2778:Michael Stratton
2698:John C. Marshall
2681:Peter Simon Liss
2584:Fraser Armstrong
2540:
2533:
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2207:Sinninghe Damsté
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1808:20 December 2018
1788:2 September 2016
1786:Gurdon Institute
1769:
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1711:. 4 August 2020.
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1221:Retraction Watch
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1084:Retraction Watch
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875:. 7 August 2024.
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355:Gurdon Institute
299:Gurdon Institute
272:
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268:.stevejacksonlab
267:
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258:/research-groups
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228:Doctoral advisor
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2846:Richard Schrock
2804:
2788:Ulrike Tillmann
2761:Evgeny Sklyanin
2751:George Sawatzky
2666:Nicholas Kaiser
2661:Stephen Jackson
2557:
2544:
2514:
2509:
2396:
2337:
2230:
2123:
2010:
1845:
1843:Heineken Prizes
1840:
1798:15 January 2018
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1729:. 14 July 2022.
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1280:. 17 April 2019
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1165:(7452): 70–74.
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869:"Steve Jackson"
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433:and another in
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41:Stephen Jackson
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351:transcription
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72:(age 62)
58:
54:
50:
45:
38:
33:
30:
19:
2836:Peter Marler
2831:Ho-Kwang Mao
2826:Barbara Hohn
2792:
2765:
2743:
2721:
2716:Peter Parham
2714:
2710:Anne O'Garra
2702:
2692:Yiu-Wing Mai
2690:
2641:Brian Foster
2621:Fergus Craik
2613:
2574:Dario Alessi
2498:Van Lieshout
2492:Dröge Wendel
1762:
1753:
1744:
1735:
1726:
1717:
1708:
1699:
1690:
1681:
1672:
1663:
1654:
1645:
1636:
1627:
1615:. Retrieved
1605:
1593:. Retrieved
1583:
1569:
1560:
1551:
1542:
1532:
1523:
1514:
1503:
1489:
1462:
1458:
1448:
1434:
1425:
1416:
1365:
1361:
1351:
1308:
1304:
1294:
1284:20 September
1282:. Retrieved
1277:
1268:
1243:
1220:
1218:,
1162:
1158:
1148:
1107:
1103:
1093:
1083:
1081:,
1017:
1013:
1003:
993:18 September
991:. Retrieved
987:
977:
967:18 September
965:. Retrieved
961:
951:
941:18 September
939:. Retrieved
935:
925:
915:18 September
913:. Retrieved
908:
899:
890:
881:
872:
863:
854:
851:"Management"
845:
831:
817:
803:
789:
762:
758:
748:
713:
709:
669:
665:
619:
615:
609:
566:
562:
552:
541:
533:
526:
519:
499:Jackson was
498:
490:
482:
474:
462:
446:
434:
430:
420:
418:
406:
397:
387:) inhibitor
378:
359:
343:Robert Tjian
340:
312:
278:
277:
214:
191:Institutions
181:Cell biology
162:
70:17 July 1962
29:
2888:1962 births
2631:John Duncan
2302:McKitterick
2248:Van der Wee
1759:"No. 64082"
1727:Merck Group
988:BristolLive
936:BristolLive
393:AstraZeneca
125:EMBO member
2882:Categories
2723:Ian Parker
2671:Mark Kisin
2646:Derek Fray
2599:Jon Blundy
2456:Van Golden
2373:McClelland
2189:Brunekreef
2118:Deisseroth
2040:Montagnier
1881:Van Deenen
1278:Genome Web
511:References
484:Society's
362:DNA damage
323:Jean Beggs
233:Jean Beggs
177:DNA repair
111:DNA damage
77:Nottingham
66:1962-07-17
2594:John Bell
2480:Struycken
2468:B. Visser
2462:Koelewijn
2420:C. Visser
2385:Kanwisher
2361:Tomasello
2278:Schilling
2165:Harremoës
2112:Carmeliet
2070:Blackburn
2022:Lauterbur
1903:Reichardt
1893:Weissmann
1806:Abcam plc
1595:24 August
1543:For staff
1390:1476-4687
1325:1095-9203
1132:1095-9203
1042:1095-9203
644:205020792
395:in 2005.
372:and ATR (
309:Education
79:, England
2860:Honorary
2686:Jan Löwe
2553:elected
2349:Anderson
2272:De Vries
2225:Le Quéré
2201:Laurance
2171:Thompson
2135:Lovelock
2088:Steinman
2052:Marshall
2028:Van Rood
2015:Medicine
2005:Stillman
1981:De Lange
1963:Jeffreys
1927:Berridge
1857:Chargaff
1481:12016139
1408:30976101
1343:30975768
1260:32284556
1216:30976101
1197:23708966
1140:30262489
1079:30975768
1060:20829486
909:BBC News
781:15289453
740:21363960
688:28622525
601:19847258
501:knighted
389:Olaparib
337:Research
2809:Foreign
2562:Fellows
2555:in 2008
2549:of the
2547:Fellows
2474:Manders
2432:Martens
2408:Verhoef
2391:Zatorre
2355:Dehaene
2326:McNeill
2314:Assmann
2284:Le Goff
2260:Oberman
2235:History
2159:Ehrlich
2141:Branica
2106:Jackson
2100:Alitalo
2094:Clevers
2046:De Wied
2034:Moncada
1969:Szostak
1945:Rothman
1875:De Duve
1863:Brachet
1399:6554193
1370:Bibcode
1334:6558281
1305:Science
1188:3859897
1167:Bibcode
1112:Bibcode
1104:Science
1051:3276839
1022:Bibcode
1014:Science
731:3049283
636:8422676
592:2906700
571:Bibcode
503:in the
431:Science
422:Science
345:at the
287:FMedSci
243:Website
135:FMedSci
2506:(2020)
2500:(2018)
2494:(2016)
2488:(2014)
2482:(2012)
2476:(2010)
2470:(2008)
2464:(2006)
2458:(2004)
2452:(2002)
2446:(2000)
2444:Geelen
2440:(1998)
2434:(1996)
2428:(1994)
2426:Röling
2422:(1992)
2416:(1990)
2410:(1988)
2393:(2020)
2387:(2018)
2381:(2016)
2379:Spelke
2375:(2014)
2369:(2012)
2367:Duncan
2363:(2010)
2357:(2008)
2351:(2006)
2334:(2020)
2332:Daston
2328:(2018)
2322:(2016)
2320:Herrin
2316:(2014)
2310:(2012)
2308:Parker
2304:(2010)
2298:(2008)
2296:Israel
2292:(2006)
2286:(2004)
2280:(2002)
2274:(2000)
2268:(1998)
2262:(1996)
2256:(1994)
2250:(1992)
2244:(1990)
2227:(2020)
2221:(2018)
2219:Hebert
2215:(2016)
2209:(2014)
2203:(2012)
2197:(2010)
2195:Tilman
2191:(2008)
2185:(2006)
2179:(2004)
2173:(2002)
2167:(2000)
2161:(1998)
2155:(1996)
2149:(1994)
2143:(1992)
2137:(1990)
2120:(2020)
2114:(2018)
2108:(2016)
2102:(2014)
2096:(2012)
2090:(2010)
2084:(2008)
2078:(2006)
2072:(2004)
2066:(2002)
2064:Selkoe
2060:(2000)
2058:Kandel
2054:(1998)
2048:(1996)
2042:(1994)
2036:(1992)
2030:(1990)
2024:(1989)
2007:(2020)
2001:(2018)
1999:Zhuang
1995:(2016)
1993:Doudna
1989:(2014)
1987:Dobson
1983:(2012)
1977:(2010)
1971:(2008)
1965:(2006)
1959:(2004)
1953:(2002)
1947:(2000)
1941:(1998)
1939:Pawson
1935:(1996)
1929:(1994)
1923:(1992)
1917:(1990)
1911:(1988)
1905:(1985)
1901:&
1899:Julesz
1895:(1982)
1889:(1979)
1883:(1976)
1877:(1973)
1871:(1970)
1869:Chance
1865:(1967)
1859:(1964)
1617:10 May
1479:
1406:
1396:
1388:
1362:Nature
1341:
1331:
1323:
1258:
1244:Nature
1214:
1210:,
1195:
1185:
1159:Nature
1138:
1130:
1077:
1073:,
1058:
1048:
1040:
779:
738:
728:
686:
642:
634:
599:
589:
563:Nature
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