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Systemic Lupus
Erythematosus (AMP RA/SLE) Consortium; Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 Jul;20(7):928-942. doi: 10.1038/s41590-019-0378-1.
269:. His contributions to computational biology include standard methods in the analysis of transcriptome data, methods to interpret biological data with statistical text mining, and integrative methods to jointly analyze multiple functional genomic modalities together. He has developed methods to map complex trait loci, most notable within the HLA locus. He has also contributed to understanding how complex trait alleles influence gene regulation, particularly in T cells.
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Seddon JM, Yu Y, Miller EC, Reynolds R, Tan PL, Gowrisankar S, Goldstein JI, Triebwasser M, Anderson HE, Zerbib J, Kavanagh D, Souied E, Katsanis N, Daly MJ, Atkinson JP, Raychaudhuri S. Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nat
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Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM 2nd; Accelerating
Medicines Partnership Rheumatoid Arthritis and
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Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, Alfredsson L, Padyukov L, Klareskog L, Worthington J, Siminovitch KA, Bae SC, Plenge RM, Gregersen PK, de Bakker PI. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid
292:
Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, Raychaudhuri S. Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nat Genet. 2015 Aug;47(8):898-905. doi:
304:
Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S. Single-cell eQTL models reveal dynamic T cell state dependence of disease loci. Nature. 2022 Jun;606(7912):120-128. doi:
240:
where he completed his M.D. and Ph.D. degrees. He pursued clinical training in internal medicine, followed by subspecialty training in rheumatology at BWH. He concurrently completed postdoctoral training in human genetics at the Broad
Institute with
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Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh PR, Raychaudhuri S. Fast, sensitive and accurate integration of single-cell data with
Harmony. Nat Methods. 2019 Dec;16(12):1289-1296. doi:
285:
Trynka G, Sandor C, Han B, Xu H, Stranger BE, Liu XS, Raychaudhuri S. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet. 2013 Feb;45(2):124-30. doi: 10.1038/ng.2504.
278:
Raychaudhuri S, Stuart JM, Altman RB. Principal components analysis to summarize microarray experiments: application to sporulation time series. Pac Symp
Biocomput. 2000:455-66. doi: 10.1142/9789814447331_0043.
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His lab at
Harvard uses human genetics, functional genomics and bioinformatics techniques to study immune mediated diseases, such as
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245:. In 2010, he launched his laboratory and joined the faculty at Harvard Medical School. He was promoted to Professor in 2018.
500:"The 2016 ACR Award Winners Discuss Their Contributions to Rheumatology Research, Education, Patient Care - Page 5 of 11"
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216:. He is the JS Coblyn and MB Brenner Distinguished Chair in Rheumatology/Immunology and a practicing rheumatologist at
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Raychaudhuri completed his undergraduate degrees in biophysics and mathematics from
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Using text to enhance the interpretation of large multi-dimensional data sets
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Beijing
Institute of Life Sciences, Chinese Academy of Sciences. 2017.
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arthritis. Nat Genet. 2012 Jan 29;44(3):291-6. doi: 10.1038/ng.1076.
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and computational genomics to understand immune-mediated diseases.
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Fellow, American
Association for the Advancement of Science
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Society of Clinical Investigation
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is a professor of medicine and biomedical informatics at
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Genet. 2013 Nov;45(11):1366-70. doi: 10.1038/ng.2741.
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567:"2023 AAAS Fellows"
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