437:
2835:
31:
405:" (often simply "double-barrel") fold. The former is seen in almost all DNA polymerases and almost all viral single-subunit polymerases; they are marked by a conserved "palm" domain. The latter is seen in all multi-subunit RNA polymerases, in cRdRP, and in "family D" DNA polymerases found in archaea. The "X" family represented by
2362:
2476:
430:. Archae and eukaryotic primases form an unrelated AEP family, possibly related to the polymerase palm. Both families nevertheless associate to the same set of helicases.
1836:
1859:
2372:
1642:
1808:
2346:
2367:
2487:
2465:
2451:
2283:
483:
2498:
768:"Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members"
2426:
2393:
436:
1954:
2288:
1914:
838:
2455:
719:"Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins"
1402:
1365:
943:
510:"Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination"
2094:
262:
125:
1337:
422:
Primases generally don't fall into either category. Bacterial primases usually have the Toprim domain, and are related to
2228:
1485:
453:
374:
121:
2554:
1798:
1592:
1494:
1060:
1208:
876:
1939:
1547:
1407:
2710:
2512:
2507:
2067:
1885:
1217:
1067:
831:
243:
106:
1530:
2377:
2265:
2233:
2218:
864:
478:
378:
187:
1900:
851:
17:
1196:
816:
2825:
1313:
1182:
1014:
961:
855:
1570:
2811:
2798:
2785:
2772:
2759:
2746:
2733:
2695:
1776:
1391:
473:
110:
2705:
2659:
2602:
1963:
1944:
1875:
1729:
1609:
1552:
824:
54:
2607:
1821:
954:
885:
2275:
2048:
1958:
1451:
1382:
233:
2628:
2547:
2129:
2084:
1786:
1771:
1707:
1687:
1585:
1377:
1146:
298:
253:
179:
2700:
2043:
2038:
1918:
1781:
1761:
1670:
1424:
1397:
1348:
229:
225:
8:
2664:
2306:
2298:
2079:
1746:
1682:
1646:
1154:
406:
249:
2597:
2169:
2107:
2058:
1793:
1620:
792:
767:
694:
667:
666:
Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM (December 2006).
327:
283:
743:
718:
627:"The Extended "Two-Barrel" Polymerases Superfamily: Structure, Function and Evolution"
603:
567:
550:
2855:
2184:
2174:
2164:
2089:
2073:
2032:
2018:
2013:
1751:
1714:
1360:
1177:
797:
748:
699:
648:
607:
572:
531:
427:
333:
323:
271:
257:
221:
215:
114:
103:
94:
409:
has only a vague "palm" shape, and is sometimes considered a different superfamily (
2860:
2643:
2638:
2612:
2540:
2517:
2179:
2159:
2101:
1997:
1895:
1880:
1826:
1724:
1719:
1578:
1317:
1166:
1161:
1053:
787:
779:
738:
730:
689:
679:
638:
599:
562:
521:
488:
319:
275:
203:
2690:
2674:
2587:
2440:
2430:
2252:
2223:
1849:
1756:
1741:
1322:
914:
847:
684:
415:
397:
370:
166:
158:
2839:
2728:
2669:
2408:
2247:
2154:
2146:
2023:
1986:
1170:
1150:
391:
Polymerases are generally split into two superfamilies, the "right hand" fold (
312:
196:
70:
66:
35:
643:
626:
526:
509:
2849:
2633:
2592:
1677:
1372:
1299:
909:
734:
423:
353:
2582:
1766:
1736:
1665:
1511:
801:
703:
668:"The structure of an RNAi polymerase links RNA silencing and transcription"
652:
611:
535:
279:
128:
also known to have template independent and template dependent activities.
62:
42:
752:
576:
2806:
2741:
2577:
2332:
2322:
1923:
1660:
1601:
1456:
846:
783:
458:
402:
89:
2134:
1890:
1655:
1605:
1600:
1542:
1516:
1304:
1289:
304:
2780:
2754:
2413:
2326:
1863:
1629:
1480:
1294:
1284:
82:
2834:
2260:
1840:
1557:
1538:
1110:
1101:
899:
468:
410:
392:
2363:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
2211:
2196:
1812:
1121:
1096:
1091:
923:
346:
342:
120:
A polymerase may be template-dependent or template-independent.
58:
30:
27:
Class of enzymes which synthesize nucleic acid chains or polymers
81:
molecules, respectively, by copying a DNA template strand using
2793:
2563:
2189:
1624:
463:
337:
50:
2767:
2206:
2201:
2053:
1471:
1466:
1461:
1444:
1439:
1434:
1429:
1417:
1412:
1130:
1125:
1082:
1077:
1072:
665:
551:"Structure of the RNA-dependent RNA polymerase of poliovirus"
237:
442:
2117:
2112:
2008:
2003:
1702:
1697:
1692:
1353:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1114:
1044:
1039:
1034:
1029:
1024:
1019:
1007:
1000:
991:
986:
981:
976:
971:
966:
928:
904:
892:
291:
287:
211:
207:
2532:
590:
Cramer P (February 2002). "Multisubunit RNA polymerases".
78:
74:
507:
765:
265:(TDT), which lends diversity to antibody heavy chains.
2823:
2373:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
2378:
CDP-diacylglycerol—choline O-phosphatidyltransferase
57:
2.7.7.6/7/19/48/49) that synthesizes long chains of
2368:
CDP-diacylglycerol—serine O-phosphatidyltransferase
124:is an example of template independent polymerase.
716:
717:Aravind L, Leipe DD, Koonin EV (September 1998).
548:
2847:
766:Iyer LM, Koonin EV, Leipe DD, Aravind L (2005).
508:Loc'h J, Rosario S, Delarue M (September 2016).
85:interactions or RNA by half ladder replication.
484:Reverse transcription polymerase chain reaction
549:Hansen JL, Long AM, Schultz SC (August 1997).
2548:
1586:
832:
2394:N-acetylglucosamine-1-phosphate transferase
2284:UTP—glucose-1-phosphate uridylyltransferase
583:
2555:
2541:
1593:
1579:
839:
825:
542:
2488:serine/threonine-specific protein kinases
2466:serine/threonine-specific protein kinases
2289:Galactose-1-phosphate uridylyltransferase
791:
742:
693:
683:
642:
566:
525:
362:Eukaryotic cellular (cRdRP; dual-subunit)
137:Classes of Template dependent polymerase
618:
301:(RT; RNA-directed DNA polymerase; RdDP)
29:
624:
14:
2848:
589:
2536:
1574:
820:
592:Current Opinion in Structural Biology
263:Terminal deoxynucleotidyl transferase
126:Terminal deoxynucleotidyl transferase
356:(RNA-directed RNA polymerase, RdRP)
199:(DNA-directed DNA polymerase, DdDP)
24:
454:Central dogma of molecular biology
25:
2872:
1799:Glucose-1,6-bisphosphate synthase
1495:Control of chromosome duplication
1061:Autonomously replicating sequence
812:
2833:
1940:Ribose-phosphate diphosphokinase
435:
386:
759:
710:
659:
501:
131:
13:
1:
2513:Protein-histidine tele-kinase
2508:Protein-histidine pros-kinase
2387:Glycosyl-1-phosphotransferase
1218:DNA polymerase III holoenzyme
1068:Single-strand binding protein
604:10.1016/S0959-440X(02)00294-4
568:10.1016/S0969-2126(97)00261-X
494:
367:Template-less RNA elongation
244:DNA polymerase III holoenzyme
184:RNA dependent RNA polymerase
176:RNA dependent DNA polymerase
163:DNA dependent RNA-polymerase
155:DNA dependent DNA-polymerase
109:, EC 2.7.7.7) is used in the
2219:RNA-dependent RNA polymerase
685:10.1371/journal.pbio.0040434
631:Journal of Molecular Biology
625:Sauguet L (September 2019).
113:, an important technique of
7:
2562:
2126:RNA-directed DNA polymerase
1994:DNA-directed DNA polymerase
447:
426:and mitochondrial helicase
10:
2877:
2479:: protein-dual-specificity
1314:Prokaryotic DNA polymerase
1015:Minichromosome maintenance
962:Origin recognition complex
88:A DNA polymerase from the
2719:
2711:Michaelis–Menten kinetics
2683:
2652:
2621:
2570:
2497:
2475:
2450:
2425:
2406:
2386:
2355:
2345:
2315:
2297:
2274:
2246:
2145:
1985:
1976:
1953:
1913:
1858:
1835:
1807:
1641:
1617:
1529:
1503:
1392:Eukaryotic DNA polymerase
1333:
1204:
1195:
1139:
939:
872:
863:
644:10.1016/j.jmb.2019.05.017
527:10.1016/j.str.2016.06.014
332:Single-subunit (ssDdRP):
111:polymerase chain reaction
2603:Diffusion-limited enzyme
2456:protein-serine/threonine
2356:Phosphatidyltransferases
1945:Thiamine diphosphokinase
318:Multi-subunit (msDdRP):
282:repair polymerases; Pol
955:Pre-replication complex
886:Pre-replication complex
2276:Nucleotidyltransferase
1959:nucleotidyltransferase
1886:Nucleoside-diphosphate
772:Nucleic Acids Research
735:10.1093/nar/26.18.4205
723:Nucleic Acids Research
401:) and the "double psi
359:Viral (single-subunit)
38:
2696:Eadie–Hofstee diagram
2629:Allosteric regulation
2130:Reverse transcriptase
1378:Replication protein A
1147:Origin of replication
299:Reverse transcriptase
188:RdRp or RNA-replicase
180:Reverse transcriptase
73:are used to assemble
33:
2706:Lineweaver–Burk plot
1919:diphosphotransferase
1901:Thiamine-diphosphate
1608:-containing groups (
1349:Replication factor C
2501:: protein-histidine
2419:; protein acceptor)
2307:mRNA capping enzyme
2299:Guanylyltransferase
407:DNA polymerase beta
138:
2665:Enzyme superfamily
2598:Enzyme promiscuity
1777:Phosphoinositide 3
1621:phosphotransferase
784:10.1093/nar/gki702
328:RNA polymerase III
136:
39:
36:Taq DNA polymerase
2821:
2820:
2530:
2529:
2526:
2525:
2402:
2401:
2341:
2340:
2242:
2241:
2155:Template-directed
1909:
1908:
1876:Phosphomevalonate
1568:
1567:
1525:
1524:
1361:Flap endonuclease
1191:
1190:
1178:Okazaki fragments
637:(20): 4167–4183.
334:T7 RNA polymerase
324:RNA polymerase II
272:DNA polymerase IV
222:DNA polymerase II
193:
192:
122:Poly-A-polymerase
115:molecular biology
95:Thermus aquaticus
16:(Redirected from
2868:
2838:
2837:
2829:
2701:Hanes–Woolf plot
2644:Enzyme activator
2639:Enzyme inhibitor
2613:Enzyme catalysis
2557:
2550:
2543:
2534:
2533:
2518:Histidine kinase
2441:tyrosine kinases
2431:protein-tyrosine
2423:
2422:
2353:
2352:
2160:RNA polymerase I
1983:
1982:
1974:
1973:
1827:Aspartate kinase
1822:Phosphoglycerate
1639:
1638:
1595:
1588:
1581:
1572:
1571:
1318:DNA polymerase I
1202:
1201:
1162:Replication fork
1054:Licensing factor
870:
869:
841:
834:
827:
818:
817:
806:
805:
795:
763:
757:
756:
746:
714:
708:
707:
697:
687:
663:
657:
656:
646:
622:
616:
615:
587:
581:
580:
570:
546:
540:
539:
529:
505:
489:RNA ligase (ATP)
439:
320:RNA polymerase I
276:DNA polymerase V
274:(DinB) and
204:DNA polymerase I
173:Template is RNA
152:Template is DNA
139:
135:
21:
2876:
2875:
2871:
2870:
2869:
2867:
2866:
2865:
2846:
2845:
2844:
2832:
2824:
2822:
2817:
2729:Oxidoreductases
2715:
2691:Enzyme kinetics
2679:
2675:List of enzymes
2648:
2617:
2588:Catalytic triad
2566:
2561:
2531:
2522:
2493:
2471:
2446:
2417:
2411:
2407:2.7.10-2.7.13:
2398:
2382:
2349:: miscellaneous
2337:
2311:
2293:
2270:
2253:exoribonuclease
2250:
2238:
2224:Polyadenylation
2141:
1967:
1961:
1949:
1931:
1927:
1921:
1905:
1867:
1854:
1831:
1803:
1633:
1627:
1619:
1613:
1599:
1569:
1564:
1521:
1499:
1339:
1335:
1329:
1323:Klenow fragment
1206:
1187:
1171:leading strands
1135:
945:
941:
935:
874:
859:
848:DNA replication
845:
815:
810:
809:
778:(12): 3875–96.
764:
760:
729:(18): 4205–13.
715:
711:
664:
660:
623:
619:
588:
584:
547:
543:
506:
502:
497:
450:
443:
440:
389:
371:Polyadenylation
185:
177:
167:RNA polymerases
164:
159:DNA polymerases
156:
147:RNA-polymerase
144:DNA-polymerase
134:
28:
23:
22:
15:
12:
11:
5:
2874:
2864:
2863:
2858:
2843:
2842:
2819:
2818:
2816:
2815:
2802:
2789:
2776:
2763:
2750:
2737:
2723:
2721:
2717:
2716:
2714:
2713:
2708:
2703:
2698:
2693:
2687:
2685:
2681:
2680:
2678:
2677:
2672:
2667:
2662:
2656:
2654:
2653:Classification
2650:
2649:
2647:
2646:
2641:
2636:
2631:
2625:
2623:
2619:
2618:
2616:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2574:
2572:
2568:
2567:
2560:
2559:
2552:
2545:
2537:
2528:
2527:
2524:
2523:
2521:
2520:
2515:
2510:
2504:
2502:
2495:
2494:
2492:
2491:
2482:
2480:
2473:
2472:
2470:
2469:
2460:
2458:
2448:
2447:
2445:
2444:
2435:
2433:
2420:
2415:
2409:protein kinase
2404:
2403:
2400:
2399:
2397:
2396:
2390:
2388:
2384:
2383:
2381:
2380:
2375:
2370:
2365:
2359:
2357:
2350:
2343:
2342:
2339:
2338:
2336:
2335:
2330:
2319:
2317:
2313:
2312:
2310:
2309:
2303:
2301:
2295:
2294:
2292:
2291:
2286:
2280:
2278:
2272:
2271:
2269:
2268:
2263:
2257:
2255:
2248:Phosphorolytic
2244:
2243:
2240:
2239:
2237:
2236:
2231:
2226:
2221:
2216:
2215:
2214:
2209:
2204:
2194:
2193:
2192:
2182:
2177:
2172:
2167:
2162:
2157:
2151:
2149:
2147:RNA polymerase
2143:
2142:
2140:
2139:
2138:
2137:
2127:
2123:
2122:
2121:
2120:
2115:
2110:
2099:
2098:
2097:
2092:
2087:
2082:
2071:
2065:
2064:
2063:
2056:
2051:
2046:
2041:
2030:
2029:
2028:
2021:
2016:
2011:
2006:
1995:
1991:
1989:
1987:DNA polymerase
1980:
1971:
1965:
1951:
1950:
1948:
1947:
1942:
1936:
1934:
1929:
1925:
1911:
1910:
1907:
1906:
1904:
1903:
1898:
1893:
1888:
1883:
1878:
1872:
1870:
1865:
1856:
1855:
1853:
1852:
1846:
1844:
1833:
1832:
1830:
1829:
1824:
1818:
1816:
1805:
1804:
1802:
1801:
1796:
1791:
1790:
1789:
1784:
1774:
1772:Diacylglycerol
1769:
1764:
1759:
1754:
1749:
1744:
1739:
1734:
1733:
1732:
1722:
1717:
1712:
1711:
1710:
1705:
1700:
1695:
1690:
1683:Phosphofructo-
1680:
1675:
1674:
1673:
1663:
1658:
1652:
1650:
1636:
1631:
1615:
1614:
1598:
1597:
1590:
1583:
1575:
1566:
1565:
1563:
1562:
1561:
1560:
1555:
1550:
1535:
1533:
1527:
1526:
1523:
1522:
1520:
1519:
1514:
1507:
1505:
1501:
1500:
1498:
1497:
1491:
1490:
1489:
1488:
1477:
1476:
1475:
1474:
1469:
1464:
1459:
1449:
1448:
1447:
1442:
1437:
1432:
1422:
1421:
1420:
1415:
1410:
1405:
1395:
1388:
1387:
1386:
1385:
1375:
1370:
1369:
1368:
1358:
1357:
1356:
1345:
1343:
1331:
1330:
1328:
1327:
1326:
1325:
1310:
1309:
1308:
1307:
1297:
1292:
1287:
1282:
1281:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1214:
1212:
1199:
1193:
1192:
1189:
1188:
1186:
1185:
1180:
1175:
1174:
1173:
1158:
1157:
1143:
1141:
1137:
1136:
1134:
1133:
1128:
1118:
1117:
1107:
1106:
1105:
1104:
1099:
1088:
1087:
1086:
1085:
1080:
1075:
1064:
1063:
1057:
1056:
1050:
1049:
1048:
1047:
1042:
1037:
1032:
1027:
1022:
1011:
1010:
1004:
1003:
997:
996:
995:
994:
989:
984:
979:
974:
969:
958:
957:
951:
949:
944:preparation in
937:
936:
934:
933:
932:
931:
920:
919:
918:
917:
912:
907:
896:
895:
889:
888:
882:
880:
867:
861:
860:
844:
843:
836:
829:
821:
814:
813:External links
811:
808:
807:
758:
709:
658:
617:
582:
561:(8): 1109–22.
541:
520:(9): 1452–63.
499:
498:
496:
493:
492:
491:
486:
481:
476:
471:
466:
461:
456:
449:
446:
445:
444:
441:
434:
424:topoisomerases
388:
385:
384:
383:
382:
381:
365:
364:
363:
360:
351:
350:
349:
340:
330:
313:RNA polymerase
309:
308:
307:
296:
295:
294:
268:
267:
266:
248:Family X: Pol
246:
240:
218:
197:DNA polymerase
191:
190:
182:
174:
170:
169:
161:
153:
149:
148:
145:
142:
133:
130:
71:RNA polymerase
67:DNA polymerase
26:
9:
6:
4:
3:
2:
2873:
2862:
2859:
2857:
2854:
2853:
2851:
2841:
2836:
2831:
2830:
2827:
2813:
2809:
2808:
2803:
2800:
2796:
2795:
2790:
2787:
2783:
2782:
2777:
2774:
2770:
2769:
2764:
2761:
2757:
2756:
2751:
2748:
2744:
2743:
2738:
2735:
2731:
2730:
2725:
2724:
2722:
2718:
2712:
2709:
2707:
2704:
2702:
2699:
2697:
2694:
2692:
2689:
2688:
2686:
2682:
2676:
2673:
2671:
2670:Enzyme family
2668:
2666:
2663:
2661:
2658:
2657:
2655:
2651:
2645:
2642:
2640:
2637:
2635:
2634:Cooperativity
2632:
2630:
2627:
2626:
2624:
2620:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2593:Oxyanion hole
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2575:
2573:
2569:
2565:
2558:
2553:
2551:
2546:
2544:
2539:
2538:
2535:
2519:
2516:
2514:
2511:
2509:
2506:
2505:
2503:
2500:
2496:
2490:
2489:
2484:
2483:
2481:
2478:
2474:
2468:
2467:
2462:
2461:
2459:
2457:
2453:
2449:
2443:
2442:
2437:
2436:
2434:
2432:
2428:
2424:
2421:
2418:
2410:
2405:
2395:
2392:
2391:
2389:
2385:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2360:
2358:
2354:
2351:
2348:
2344:
2334:
2331:
2328:
2324:
2321:
2320:
2318:
2314:
2308:
2305:
2304:
2302:
2300:
2296:
2290:
2287:
2285:
2282:
2281:
2279:
2277:
2273:
2267:
2264:
2262:
2259:
2258:
2256:
2254:
2249:
2245:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2213:
2210:
2208:
2205:
2203:
2200:
2199:
2198:
2195:
2191:
2188:
2187:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2152:
2150:
2148:
2144:
2136:
2133:
2132:
2131:
2128:
2125:
2124:
2119:
2116:
2114:
2111:
2109:
2106:
2105:
2103:
2100:
2096:
2093:
2091:
2088:
2086:
2083:
2081:
2078:
2077:
2075:
2072:
2069:
2066:
2062:
2061:
2057:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2036:
2034:
2031:
2027:
2026:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2001:
1999:
1996:
1993:
1992:
1990:
1988:
1984:
1981:
1979:
1975:
1972:
1969:
1960:
1956:
1952:
1946:
1943:
1941:
1938:
1937:
1935:
1932:
1920:
1916:
1912:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1873:
1871:
1868:
1861:
1857:
1851:
1848:
1847:
1845:
1842:
1838:
1834:
1828:
1825:
1823:
1820:
1819:
1817:
1814:
1810:
1806:
1800:
1797:
1795:
1792:
1788:
1787:Class II PI 3
1785:
1783:
1780:
1779:
1778:
1775:
1773:
1770:
1768:
1765:
1763:
1762:Deoxycytidine
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1735:
1731:
1730:ADP-thymidine
1728:
1727:
1726:
1723:
1721:
1718:
1716:
1713:
1709:
1706:
1704:
1701:
1699:
1696:
1694:
1691:
1689:
1686:
1685:
1684:
1681:
1679:
1676:
1672:
1669:
1668:
1667:
1664:
1662:
1659:
1657:
1654:
1653:
1651:
1648:
1644:
1640:
1637:
1634:
1626:
1622:
1616:
1611:
1607:
1603:
1596:
1591:
1589:
1584:
1582:
1577:
1576:
1573:
1559:
1556:
1554:
1551:
1549:
1546:
1545:
1544:
1540:
1537:
1536:
1534:
1532:
1528:
1518:
1515:
1513:
1509:
1508:
1506:
1502:
1496:
1493:
1492:
1487:
1484:
1483:
1482:
1479:
1478:
1473:
1470:
1468:
1465:
1463:
1460:
1458:
1455:
1454:
1453:
1450:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1427:
1426:
1423:
1419:
1416:
1414:
1411:
1409:
1406:
1404:
1401:
1400:
1399:
1396:
1393:
1390:
1389:
1384:
1381:
1380:
1379:
1376:
1374:
1373:Topoisomerase
1371:
1367:
1364:
1363:
1362:
1359:
1355:
1352:
1351:
1350:
1347:
1346:
1344:
1341:
1332:
1324:
1321:
1320:
1319:
1315:
1312:
1311:
1306:
1303:
1302:
1301:
1300:Topoisomerase
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1220:
1219:
1216:
1215:
1213:
1210:
1203:
1200:
1198:
1194:
1184:
1181:
1179:
1176:
1172:
1168:
1165:
1164:
1163:
1160:
1159:
1156:
1152:
1148:
1145:
1144:
1142:
1138:
1132:
1129:
1127:
1123:
1120:
1119:
1116:
1112:
1109:
1108:
1103:
1100:
1098:
1095:
1094:
1093:
1090:
1089:
1084:
1081:
1079:
1076:
1074:
1071:
1070:
1069:
1066:
1065:
1062:
1059:
1058:
1055:
1052:
1051:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1017:
1016:
1013:
1012:
1009:
1006:
1005:
1002:
999:
998:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
964:
963:
960:
959:
956:
953:
952:
950:
947:
938:
930:
927:
926:
925:
922:
921:
916:
913:
911:
908:
906:
903:
902:
901:
898:
897:
894:
891:
890:
887:
884:
883:
881:
878:
871:
868:
866:
862:
857:
853:
849:
842:
837:
835:
830:
828:
823:
822:
819:
803:
799:
794:
789:
785:
781:
777:
773:
769:
762:
754:
750:
745:
740:
736:
732:
728:
724:
720:
713:
705:
701:
696:
691:
686:
681:
677:
673:
669:
662:
654:
650:
645:
640:
636:
632:
628:
621:
613:
609:
605:
601:
597:
593:
586:
578:
574:
569:
564:
560:
556:
552:
545:
537:
533:
528:
523:
519:
515:
511:
504:
500:
490:
487:
485:
482:
480:
477:
475:
472:
470:
467:
465:
462:
460:
457:
455:
452:
451:
438:
433:
432:
431:
429:
425:
420:
418:
417:
412:
408:
404:
400:
399:
394:
380:
376:
372:
369:
368:
366:
361:
358:
357:
355:
354:RNA replicase
352:
348:
344:
341:
339:
335:
331:
329:
325:
321:
317:
316:
315:(DdRP, RNAP)
314:
311:DNA-directed
310:
306:
303:
302:
300:
297:
293:
289:
285:
281:
277:
273:
269:
264:
261:
260:
259:
255:
251:
247:
245:
241:
239:
235:
231:
227:
223:
219:
217:
213:
209:
205:
201:
200:
198:
195:
194:
189:
183:
181:
175:
172:
171:
168:
162:
160:
154:
151:
150:
146:
143:
141:
140:
129:
127:
123:
118:
116:
112:
108:
105:
101:
97:
96:
91:
86:
84:
80:
76:
72:
68:
64:
63:nucleic acids
60:
56:
52:
48:
44:
37:
34:Structure of
32:
19:
2807:Translocases
2804:
2791:
2778:
2765:
2752:
2742:Transferases
2739:
2726:
2583:Binding site
2485:
2463:
2438:
2059:
2024:
1977:
1782:Class I PI 3
1747:Pantothenate
1618:2.7.1-2.7.4:
1602:Transferases
1512:Processivity
1338:synthesis in
775:
771:
761:
726:
722:
712:
678:(12): e434.
675:
672:PLoS Biology
671:
661:
634:
630:
620:
598:(1): 89–97.
595:
591:
585:
558:
554:
544:
517:
513:
503:
421:
414:
396:
390:
387:By structure
278:(UmuD'2C) -
119:
99:
93:
90:thermophilic
87:
83:base-pairing
46:
43:biochemistry
40:
2578:Active site
2333:Transposase
2323:Recombinase
1968:-nucleoside
1794:Sphingosine
1531:Termination
1205:Prokaryotic
1197:Replication
873:Prokaryotic
852:prokaryotic
850:(comparing
459:Exonuclease
403:beta barrel
132:By function
92:bacterium,
18:Polymerases
2850:Categories
2781:Isomerases
2755:Hydrolases
2622:Regulation
2135:Telomerase
1978:Polymerase
1752:Mevalonate
1715:Riboflavin
1606:phosphorus
1543:Telomerase
1517:DNA ligase
1510:Movement:
1334:Eukaryotic
1305:DNA gyrase
1290:DNA ligase
1209:elongation
940:Eukaryotic
877:initiation
865:Initiation
856:eukaryotic
495:References
305:Telomerase
270:Family Y:
242:Family C:
220:Family B:
202:Family A:
165:or common
157:or common
47:polymerase
2660:EC number
2327:Integrase
2251:3' to 5'
1896:Guanylate
1891:Uridylate
1881:Adenylate
1725:Thymidine
1720:Shikimate
1481:DNA clamp
1295:DNA clamp
1285:Replisome
555:Structure
514:Structure
416:IPR043519
398:IPR043502
2856:EC 2.7.7
2684:Kinetics
2608:Cofactor
2571:Activity
2261:RNase PH
1869:acceptor
1850:Creatine
1843:acceptor
1815:acceptor
1757:Pyruvate
1742:Glycerol
1703:Platelet
1678:Galacto-
1649:acceptor
1539:Telomere
1155:Replicon
1111:Helicase
1102:RNASEH2A
946:G1 phase
900:Helicase
802:16027112
704:17147473
653:31103775
612:11839495
536:27499438
469:Nuclease
448:See also
411:InterPro
393:InterPro
59:polymers
2861:Enzymes
2840:Biology
2794:Ligases
2564:Enzymes
2212:PrimPol
2197:Primase
1671:Hepatic
1666:Fructo-
1452:epsilon
1340:S phase
1167:Lagging
1122:Primase
1097:RNASEH1
1092:RNase H
924:Primase
793:1176014
753:9722641
695:1750930
577:9309225
428:twinkle
413::
395::
347:PrimPol
343:Primase
2826:Portal
2768:Lyases
2499:2.7.13
2477:2.7.12
2452:2.7.11
2427:2.7.10
2266:PNPase
2234:PNPase
2190:POLRMT
2185:ssRNAP
1698:Muscle
1661:Gluco-
1625:kinase
1183:Primer
800:
790:
751:
744:147817
741:
702:
692:
651:
610:
575:
534:
464:Ligase
379:PNPase
338:POLRMT
224:; Pol
206:; Pol
51:enzyme
49:is an
2720:Types
2347:2.7.8
2316:Other
1955:2.7.7
1915:2.7.6
1860:2.7.4
1837:2.7.3
1809:2.7.2
1693:Liver
1656:Hexo-
1643:2.7.1
1472:POLE4
1467:POLE3
1462:POLE2
1445:POLD4
1440:POLD3
1435:POLD2
1430:POLD1
1425:delta
1418:PRIM2
1413:PRIM1
1408:POLA2
1403:POLA1
1398:alpha
1131:PRIM2
1126:PRIM1
1083:SSBP4
1078:SSBP3
1073:SSBP2
2812:list
2805:EC7
2799:list
2792:EC6
2786:list
2779:EC5
2773:list
2766:EC4
2760:list
2753:EC3
2747:list
2740:EC2
2734:list
2727:EC1
2486:see
2464:see
2439:see
1813:COOH
1612:2.7)
1558:DKC1
1553:TERC
1548:TERT
1504:Both
1486:PCNA
1457:POLE
1383:RPA1
1366:FEN1
1354:RFC1
1278:holE
1273:holD
1268:holC
1263:holB
1258:holA
1253:dnaX
1248:dnaT
1243:dnaQ
1238:dnaN
1233:dnaH
1228:dnaE
1223:dnaC
1169:and
1140:Both
1115:HFM1
1045:MCM7
1040:MCM6
1035:MCM5
1030:MCM4
1025:MCM3
1020:MCM2
1008:Cdt1
1001:Cdc6
992:ORC6
987:ORC5
982:ORC4
977:ORC3
972:ORC2
967:ORC1
929:dnaG
910:dnaB
905:dnaA
893:dnaC
798:PMID
749:PMID
700:PMID
649:PMID
608:PMID
573:PMID
532:PMID
479:PARP
107:1BGX
77:and
69:and
45:, a
2229:PAP
2170:III
2104:/Y
2095:TDT
2076:/X
2068:III
2060:Pfu
2035:/B
2025:Taq
2000:/A
1767:PFP
1737:NAD
1151:Ori
854:to
788:PMC
780:doi
739:PMC
731:doi
690:PMC
680:doi
639:doi
635:431
600:doi
563:doi
522:doi
474:PCR
419:).
375:PAP
280:SOS
186:or
178:or
104:PDB
102:) (
100:Taq
79:RNA
75:DNA
61:or
41:In
2852::
2454::
2429::
2414:PO
2175:IV
2165:II
2074:IV
2070:/C
2033:II
2019:T7
1964:PO
1957::
1917::
1864:PO
1862::
1839::
1811::
1647:OH
1645::
1630:PO
1610:EC
1604::
1541::
1316::
1124::
1113::
915:T7
796:.
786:.
776:33
774:.
770:.
747:.
737:.
727:26
725:.
721:.
698:.
688:.
674:.
670:.
647:.
633:.
629:.
606:.
596:12
594:.
571:.
557:.
553:.
530:.
518:24
516:.
512:.
377:,
373::
345:,
336:,
326:,
322:,
290:,
286:,
256:,
252:,
236:,
232:,
228:,
214:,
210:,
117:.
65:.
55:EC
2828::
2814:)
2810:(
2801:)
2797:(
2788:)
2784:(
2775:)
2771:(
2762:)
2758:(
2749:)
2745:(
2736:)
2732:(
2556:e
2549:t
2542:v
2416:4
2412:(
2329:)
2325:(
2207:2
2202:1
2180:V
2118:Îş
2113:Îą
2108:η
2102:V
2090:ÎĽ
2085:λ
2080:β
2054:ζ
2049:ε
2044:δ
2039:α
2014:ν
2009:θ
2004:Îł
1998:I
1970:)
1966:4
1962:(
1933:)
1930:7
1928:O
1926:2
1924:P
1922:(
1866:4
1841:N
1708:2
1688:1
1635:)
1632:4
1628:(
1623:/
1594:e
1587:t
1580:v
1394::
1342:)
1336:(
1211:)
1207:(
1153:/
1149:/
948:)
942:(
879:)
875:(
858:)
840:e
833:t
826:v
804:.
782::
755:.
733::
706:.
682::
676:4
655:.
641::
614:.
602::
579:.
565::
559:5
538:.
524::
292:Îş
288:Îą
284:η
258:ÎĽ
254:λ
250:β
238:ζ
234:ε
230:δ
226:α
216:ν
212:θ
208:Îł
98:(
53:(
20:)
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