313:
290:
212:
187:
564:
319:
218:
2456:
2298:
Yuasa MS, Masutani C, Hirano A, Cohn MA, Yamaizumi M, Nakatani Y, Hanaoka F (July 2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest".
50:
2338:"Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site"
1159:
heterodimer, and it can only act on resected DNA ends. Following annealing of short (i.e., a few nucleotides) regions on the DNA overhangs, DNA polymerase theta catalyzes template-dependent DNA synthesis across the broken ends, stabilizing the paired structure.
1931:
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening".
1155:(HDR). However, in some contexts, NHEJ and HR are insufficient and TMEJ is the only solution to repair the break. TMEJ is often described as alternative NHEJ, but differs in that it lacks a requirement for the
326:
225:
2033:
Kawamura K, Bahar R, Seimiya M, Chiyo M, Wada A, Okada S, et al. (March 2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers".
2234:
Cruet-Hennequart S, Coyne S, Glynn MT, Oakley GG, Carty MP (April 2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK".
1147:. This polymerase plays a key role in one of the three major double strand break repair pathways: theta-mediated end joining (TMEJ). Most double-strand breaks are repaired by
2158:"Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene"
1303:
Sharief FS, Vojta PJ, Ropp PA, Copeland WC (July 1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase".
1180:(MMEJ). Moreover, when break ends are not stabilized properly, the break ends can detach after polymerization. When these polymerized ends anneal again, a templated
1758:
Schimmel J, van
Schendel R, den Dunnen JT, Tijsterman M (September 2019). "Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining".
1550:
Schimmel J, van
Schendel R, den Dunnen JT, Tijsterman M (September 2019). "Templated Insertions: A Smoking Gun for Polymerase Theta-Mediated End Joining".
862:
843:
148:
1176:
from both break ends to initiate repair, which leads to loss of one set of these nucleotides in the DNA sequence. Therefore, TMEJ is a form of
1961:
Maga G, Shevelev I, Ramadan K, Spadari S, Hübscher U (May 2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme".
1285:
1267:
1074:
1081:
1338:
2525:
2501:
1250:
2520:
47:
1229:
1177:
312:
289:
1454:"A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites"
1254:
1233:
907:
1354:"Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila"
888:
2072:"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions"
2070:
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004).
211:
186:
128:
2193:"The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation"
1801:
1405:"Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions"
1148:
325:
224:
2494:
318:
217:
115:
1152:
1053:
1002:
136:
2265:"A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents"
1701:
Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, et al. (February 2015).
1057:
1032:
1006:
981:
977:
1826:
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, et al. (June 2021).
1452:
Koole W, van
Schendel R, Karambelas AE, van Heteren JT, Okihara KL, Tijsterman M (2014-02-05).
1593:
Yousefzadeh MJ, Wyatt DW, Takata K, Mu Y, Hensley SC, Tomida J, et al. (October 2014).
2487:
1839:
1714:
1657:
1465:
1181:
200:
2191:
Zan H, Shima N, Xu Z, Al-Qahtani A, Evinger Iii AJ, Zhong Y, et al. (November 2005).
2156:
Chiapperino D, Cai M, Sayer JM, Yagi H, Kroth H, Masutani C, et al. (December 2005).
1503:"Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans"
156:
8:
1644:
Mateos-Gomez PA, Gong F, Nair N, Miller KM, Lazzerini-Denchi E, Sfeir A (February 2015).
2373:"Translesion synthesis by human DNA polymerase eta across oxidative products of guanine"
1843:
1718:
1661:
1469:
2432:
2407:
2324:
2217:
2192:
2058:
1914:
1889:
1860:
1827:
1783:
1735:
1702:
1678:
1645:
1621:
1594:
1575:
1527:
1502:
1429:
1404:
1380:
1353:
160:
2139:
2114:
2096:
2071:
2016:
1991:
1974:
777:
772:
767:
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757:
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747:
742:
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732:
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686:
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660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
2437:
2394:
2359:
2336:
Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP (September 2006).
2316:
2312:
2286:
2251:
2222:
2179:
2144:
2101:
2050:
2021:
1978:
1949:
1919:
1865:
1787:
1775:
1740:
1683:
1626:
1579:
1567:
1532:
1483:
1434:
1385:
1320:
108:
40:
2328:
2113:
Seki M, Masutani C, Yang LW, Schuffert A, Iwai S, Bahar I, Wood RD (November 2004).
2062:
140:
2427:
2419:
2384:
2349:
2308:
2276:
2243:
2212:
2204:
2169:
2134:
2126:
2091:
2083:
2042:
2011:
2003:
1970:
1941:
1909:
1901:
1855:
1847:
1767:
1730:
1722:
1673:
1665:
1616:
1606:
1559:
1522:
1514:
1473:
1424:
1416:
1375:
1365:
1312:
405:
336:
280:
235:
2281:
2264:
1703:"Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair"
1200:
were long thought to only transcribe DNA into DNA or RNA and not be able to write
2247:
1611:
1370:
380:
164:
2408:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
1290:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1272:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2471:
1646:"Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination"
1197:
481:
119:, POLH, PRO0327, polymerase (DNA) theta, DNA polymerase theta, DNA polymerase θ
2475:
1771:
1563:
723:
negative regulation of double-strand break repair via homologous recombination
2514:
2208:
2130:
592:
2389:
2372:
1992:"POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells"
1595:"Mechanism of suppression of chromosomal instability by DNA polymerase POLQ"
541:
419:
2467:
2441:
2398:
2363:
2354:
2337:
2320:
2290:
2255:
2226:
2183:
2174:
2157:
2148:
2105:
2054:
2025:
1982:
1945:
1923:
1869:
1851:
1779:
1744:
1687:
1630:
1571:
1536:
1487:
1438:
1389:
1324:
1316:
1156:
563:
398:
177:
1953:
1930:
1905:
1518:
1121:
1116:
2406:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
2007:
1420:
1169:
952:
933:
1757:
1726:
1669:
1549:
2423:
2087:
1478:
1453:
1193:
1173:
297:
194:
144:
2046:
1451:
85:
81:
77:
73:
69:
807:
364:
351:
263:
250:
152:
1828:"Polθ reverse transcribes RNA and promotes RNA-templated DNA repair"
728:
double-strand break repair via alternative nonhomologous end joining
1105:
1802:"New discovery shows human cells can write RNA sequences into DNA"
919:
874:
792:
788:
2263:
Chen YW, Cleaver JE, Hanaoka F, Chang CF, Chou KM (April 2006).
2233:
2115:"High-efficiency bypass of DNA damage by human DNA polymerase Q"
2069:
572:
132:
1825:
1137:
1089:
829:
1500:
2463:
2455:
1887:
1144:
1960:
1643:
1163:
2371:
Kino K, Ito N, Sugasawa K, Sugiyama H, Hanaoka F (2007).
2112:
2032:
1700:
1205:
1201:
2335:
1592:
1302:
388:
2370:
2297:
2262:
2155:
743:
double-strand break repair via homologous recombination
1819:
1501:
Roerink SF, van
Schendel R, Tijsterman M (June 2014).
1890:"Promiscuous DNA synthesis by human DNA polymerase θ"
1888:
Hogg M, Sauer-Eriksson AE, Johansson E (March 2012).
553:
2190:
1339:"Entrez Gene: POLQ polymerase (DNA directed), theta"
1246:
1244:
1242:
1225:
1223:
1221:
335:
234:
2512:
2405:
1239:
1218:
1187:
16:Protein-coding gene in the species Homo sapiens
1989:
1251:GRCm38: Ensembl release 89: ENSMUSG00000034206
2495:
718:somatic hypermutation of immunoglobulin genes
1694:
1637:
1586:
1990:Seki M, Marini F, Wood RD (November 2003).
1351:
1296:
1230:GRCh38: Ensembl release 89: ENSG00000051341
778:nucleic acid phosphodiester bond hydrolysis
2502:
2488:
2431:
2388:
2353:
2280:
2216:
2173:
2138:
2095:
2015:
1913:
1859:
1734:
1677:
1620:
1610:
1526:
1477:
1428:
1379:
1369:
1172:, since polymerase theta uses homologous
631:5'-deoxyribose-5-phosphate lyase activity
1184:arises between the deletion junctions.
733:cellular response to DNA damage stimulus
1402:
1164:Polymerase theta's mutational signature
2513:
1352:Chan SH, Yu AM, McVey M (July 2010).
1331:
626:single-stranded DNA helicase activity
340:
301:
296:
239:
198:
193:
2450:
656:DNA-directed DNA polymerase activity
2342:The Journal of Biological Chemistry
2162:The Journal of Biological Chemistry
1178:micro-homology mediated end joining
13:
1880:
14:
2537:
1403:Yu AM, McVey M (September 2010).
1140:that in humans is encoded by the
2454:
2313:10.1111/j.1365-2443.2006.00974.x
562:
324:
317:
311:
288:
223:
216:
210:
185:
2035:International Journal of Cancer
1794:
1751:
1543:
1494:
621:nucleotidyltransferase activity
2377:Nucleic Acids Symposium Series
1445:
1396:
1345:
1278:
1260:
573:More reference expression data
542:More reference expression data
1:
2526:Human chromosome 3 gene stubs
2282:10.1158/1541-7786.MCR-05-0118
1975:10.1016/S0022-2836(02)00325-X
1211:
773:DNA-dependent DNA replication
309:
208:
2474:. You can help Knowledge by
2248:10.1016/j.dnarep.2006.01.008
1963:Journal of Molecular Biology
1612:10.1371/journal.pgen.1004654
1371:10.1371/journal.pgen.1001005
1192:Polθ promotes RNA-templated
1188:Reverse transcription of RNA
7:
2521:Genes on human chromosome 3
748:protein homooligomerization
458:stromal cell of endometrium
10:
2542:
2449:
1149:non-homologous end joining
768:double-strand break repair
666:5'-3' exonuclease activity
462:mucosa of transverse colon
2412:Molecular Systems Biology
2269:Molecular Cancer Research
1772:10.1016/j.tig.2019.06.001
1564:10.1016/j.tig.2019.06.001
1286:"Mouse PubMed Reference:"
1268:"Human PubMed Reference:"
1120:
1115:
1111:
1104:
1088:
1075:Chr 3: 121.43 – 121.55 Mb
1069:
1050:
1046:
1029:
1025:
1018:
999:
995:
974:
970:
963:
950:
946:
931:
927:
918:
905:
901:
886:
882:
873:
860:
856:
841:
837:
828:
813:
806:
802:
786:
671:identical protein binding
591:
587:
570:
561:
552:
539:
488:
479:
426:
417:
387:
379:
375:
358:
345:
308:
287:
278:
274:
257:
244:
207:
184:
175:
171:
126:
123:
113:
106:
101:
66:
61:
44:
39:
34:
30:
26:
21:
2209:10.1038/sj.emboj.7600833
2131:10.1038/sj.emboj.7600424
1153:homology directed repair
1082:Chr 16: 36.83 – 36.92 Mb
763:DNA biosynthetic process
2355:10.1074/jbc.M605699200
2175:10.1074/jbc.M508008200
1996:Nucleic Acids Research
1946:10.1006/geno.1994.1457
1894:Nucleic Acids Research
1852:10.1126/sciadv.abf1771
1409:Nucleic Acids Research
1317:10.1006/geno.1999.5843
1168:TMEJ is intrinsically
342:16 B3|16 26.32 cM
2390:10.1093/nass/48.1.171
1519:10.1101/gr.170431.113
1458:Nature Communications
303:Chromosome 16 (mouse)
1134:DNA polymerase theta
758:base-excision repair
651:nucleic acid binding
606:transferase activity
201:Chromosome 3 (human)
62:List of PDB id codes
35:Available structures
1906:10.1093/nar/gkr1102
1844:2021SciA....7.1771C
1727:10.1038/nature14184
1719:2015Natur.518..258C
1670:10.1038/nature14157
1662:2015Natur.518..254M
1470:2014NatCo...5.3216K
641:damaged DNA binding
466:gingival epithelium
446:ganglionic eminence
2462:This article on a
2424:10.1038/msb4100134
2088:10.1101/gr.2435604
2008:10.1093/nar/gkg814
1760:Trends in Genetics
1552:Trends in Genetics
1479:10.1038/ncomms4216
1421:10.1093/nar/gkq379
908:ENSMUSG00000034206
711:Biological process
680:Cellular component
611:nucleotide binding
599:Molecular function
2483:
2482:
2348:(35): 25297–306.
2047:10.1002/ijc.11666
1131:
1130:
1127:
1126:
1100:
1099:
1065:
1064:
1040:
1039:
1014:
1013:
989:
988:
959:
958:
940:
939:
914:
913:
895:
894:
869:
868:
850:
849:
798:
797:
636:chromatin binding
583:
582:
579:
578:
548:
547:
535:
534:
473:
472:
450:bone marrow cells
371:
370:
270:
269:
97:
96:
93:
92:
45:Ortholog search:
2533:
2504:
2497:
2490:
2458:
2451:
2445:
2435:
2402:
2392:
2367:
2357:
2332:
2294:
2284:
2259:
2230:
2220:
2197:The EMBO Journal
2187:
2177:
2168:(48): 39684–92.
2152:
2142:
2119:The EMBO Journal
2109:
2099:
2066:
2029:
2019:
1986:
1957:
1927:
1917:
1874:
1873:
1863:
1838:(24): eabf1771.
1832:Science Advances
1823:
1817:
1816:
1814:
1812:
1798:
1792:
1791:
1755:
1749:
1748:
1738:
1713:(7538): 258–62.
1698:
1692:
1691:
1681:
1641:
1635:
1634:
1624:
1614:
1605:(10): e1004654.
1590:
1584:
1583:
1547:
1541:
1540:
1530:
1498:
1492:
1491:
1481:
1449:
1443:
1442:
1432:
1400:
1394:
1393:
1383:
1373:
1349:
1343:
1342:
1335:
1329:
1328:
1300:
1294:
1293:
1282:
1276:
1275:
1264:
1258:
1248:
1237:
1227:
1113:
1112:
1084:
1077:
1060:
1044:
1043:
1035:
1023:
1022:
1019:RefSeq (protein)
1009:
993:
992:
984:
968:
967:
944:
943:
925:
924:
899:
898:
880:
879:
854:
853:
835:
834:
804:
803:
589:
588:
575:
566:
559:
558:
544:
528:secondary oocyte
508:ventricular zone
496:genital tubercle
484:
482:Top expressed in
477:
476:
438:ventricular zone
430:secondary oocyte
422:
420:Top expressed in
415:
414:
394:
393:
377:
376:
367:
354:
343:
328:
321:
315:
304:
292:
276:
275:
266:
253:
242:
227:
220:
214:
203:
189:
173:
172:
167:
165:POLQ - orthologs
118:
111:
88:
59:
58:
53:
32:
31:
19:
18:
2541:
2540:
2536:
2535:
2534:
2532:
2531:
2530:
2511:
2510:
2509:
2508:
2448:
2203:(21): 3757–69.
2125:(22): 4484–94.
2076:Genome Research
2002:(21): 6117–26.
1883:
1881:Further reading
1878:
1877:
1824:
1820:
1810:
1808:
1800:
1799:
1795:
1756:
1752:
1699:
1695:
1656:(7538): 254–7.
1642:
1638:
1591:
1587:
1548:
1544:
1507:Genome Research
1499:
1495:
1450:
1446:
1415:(17): 5706–17.
1401:
1397:
1364:(7): e1001005.
1350:
1346:
1337:
1336:
1332:
1301:
1297:
1284:
1283:
1279:
1266:
1265:
1261:
1249:
1240:
1228:
1219:
1214:
1198:DNA polymerases
1190:
1166:
1122:View/Edit Mouse
1117:View/Edit Human
1080:
1073:
1070:Location (UCSC)
1056:
1052:
1031:
1005:
1001:
980:
976:
889:ENSG00000051341
782:
738:DNA replication
706:
675:
646:protein binding
571:
540:
531:
526:
522:
518:
514:
510:
506:
502:
498:
494:
480:
469:
464:
460:
456:
454:trabecular bone
452:
448:
444:
440:
436:
432:
418:
362:
349:
341:
331:
330:
329:
322:
302:
279:Gene location (
261:
248:
240:
230:
229:
228:
221:
199:
176:Gene location (
127:
114:
107:
68:
46:
17:
12:
11:
5:
2539:
2529:
2528:
2523:
2507:
2506:
2499:
2492:
2484:
2481:
2480:
2459:
2447:
2446:
2403:
2368:
2333:
2301:Genes to Cells
2295:
2260:
2242:(4): 491–504.
2231:
2188:
2153:
2110:
2067:
2030:
1987:
1958:
1928:
1900:(6): 2611–22.
1884:
1882:
1879:
1876:
1875:
1818:
1793:
1766:(9): 632–644.
1750:
1693:
1636:
1585:
1558:(9): 632–644.
1542:
1493:
1444:
1395:
1344:
1330:
1295:
1277:
1259:
1238:
1216:
1215:
1213:
1210:
1204:segments into
1196:. Previously,
1189:
1186:
1165:
1162:
1129:
1128:
1125:
1124:
1119:
1109:
1108:
1102:
1101:
1098:
1097:
1095:
1093:
1086:
1085:
1078:
1071:
1067:
1066:
1063:
1062:
1048:
1047:
1041:
1038:
1037:
1027:
1026:
1020:
1016:
1015:
1012:
1011:
997:
996:
990:
987:
986:
972:
971:
965:
961:
960:
957:
956:
948:
947:
941:
938:
937:
929:
928:
922:
916:
915:
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911:
903:
902:
896:
893:
892:
884:
883:
877:
871:
870:
867:
866:
858:
857:
851:
848:
847:
839:
838:
832:
826:
825:
820:
815:
811:
810:
800:
799:
796:
795:
784:
783:
781:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
689:
683:
681:
677:
676:
674:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
602:
600:
596:
595:
585:
584:
581:
580:
577:
576:
568:
567:
556:
550:
549:
546:
545:
537:
536:
533:
532:
530:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
492:tail of embryo
489:
486:
485:
474:
471:
470:
468:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
424:
423:
411:
410:
402:
391:
385:
384:
381:RNA expression
373:
372:
369:
368:
360:
356:
355:
347:
344:
339:
333:
332:
323:
316:
310:
306:
305:
300:
294:
293:
285:
284:
272:
271:
268:
267:
259:
255:
254:
246:
243:
238:
232:
231:
222:
215:
209:
205:
204:
197:
191:
190:
182:
181:
169:
168:
125:
121:
120:
112:
104:
103:
99:
98:
95:
94:
91:
90:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
9:
6:
4:
3:
2:
2538:
2527:
2524:
2522:
2519:
2518:
2516:
2505:
2500:
2498:
2493:
2491:
2486:
2485:
2479:
2477:
2473:
2469:
2465:
2460:
2457:
2453:
2452:
2443:
2439:
2434:
2429:
2425:
2421:
2417:
2413:
2409:
2404:
2400:
2396:
2391:
2386:
2383:(48): 171–2.
2382:
2378:
2374:
2369:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2334:
2330:
2326:
2322:
2318:
2314:
2310:
2307:(7): 731–44.
2306:
2302:
2296:
2292:
2288:
2283:
2278:
2275:(4): 257–65.
2274:
2270:
2266:
2261:
2257:
2253:
2249:
2245:
2241:
2237:
2232:
2228:
2224:
2219:
2214:
2210:
2206:
2202:
2198:
2194:
2189:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2154:
2150:
2146:
2141:
2136:
2132:
2128:
2124:
2120:
2116:
2111:
2107:
2103:
2098:
2093:
2089:
2085:
2082:(9): 1711–8.
2081:
2077:
2073:
2068:
2064:
2060:
2056:
2052:
2048:
2044:
2040:
2036:
2031:
2027:
2023:
2018:
2013:
2009:
2005:
2001:
1997:
1993:
1988:
1984:
1980:
1976:
1972:
1969:(2): 359–69.
1968:
1964:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1929:
1925:
1921:
1916:
1911:
1907:
1903:
1899:
1895:
1891:
1886:
1885:
1871:
1867:
1862:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1822:
1807:
1803:
1797:
1789:
1785:
1781:
1777:
1773:
1769:
1765:
1761:
1754:
1746:
1742:
1737:
1732:
1728:
1724:
1720:
1716:
1712:
1708:
1704:
1697:
1689:
1685:
1680:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1640:
1632:
1628:
1623:
1618:
1613:
1608:
1604:
1600:
1599:PLOS Genetics
1596:
1589:
1581:
1577:
1573:
1569:
1565:
1561:
1557:
1553:
1546:
1538:
1534:
1529:
1524:
1520:
1516:
1513:(6): 954–62.
1512:
1508:
1504:
1497:
1489:
1485:
1480:
1475:
1471:
1467:
1463:
1459:
1455:
1448:
1440:
1436:
1431:
1426:
1422:
1418:
1414:
1410:
1406:
1399:
1391:
1387:
1382:
1377:
1372:
1367:
1363:
1359:
1358:PLOS Genetics
1355:
1348:
1340:
1334:
1326:
1322:
1318:
1314:
1310:
1306:
1299:
1291:
1287:
1281:
1273:
1269:
1263:
1256:
1252:
1247:
1245:
1243:
1235:
1231:
1226:
1224:
1222:
1217:
1209:
1207:
1203:
1199:
1195:
1185:
1183:
1179:
1175:
1171:
1161:
1158:
1154:
1150:
1146:
1143:
1139:
1135:
1123:
1118:
1114:
1110:
1107:
1103:
1096:
1094:
1091:
1087:
1083:
1079:
1076:
1072:
1068:
1061:
1059:
1055:
1049:
1045:
1042:
1036:
1034:
1028:
1024:
1021:
1017:
1010:
1008:
1004:
998:
994:
991:
985:
983:
979:
973:
969:
966:
964:RefSeq (mRNA)
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
910:
909:
904:
900:
897:
891:
890:
885:
881:
878:
876:
872:
865:
864:
859:
855:
852:
846:
845:
840:
836:
833:
831:
827:
824:
821:
819:
816:
812:
809:
805:
801:
794:
790:
785:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
684:
682:
679:
678:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
603:
601:
598:
597:
594:
593:Gene ontology
590:
586:
574:
569:
565:
560:
557:
555:
551:
543:
538:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
490:
487:
483:
478:
475:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
428:
425:
421:
416:
413:
412:
409:
407:
403:
401:
400:
396:
395:
392:
390:
386:
382:
378:
374:
366:
361:
357:
353:
348:
338:
334:
327:
320:
314:
307:
299:
295:
291:
286:
282:
277:
273:
265:
260:
256:
252:
247:
237:
233:
226:
219:
213:
206:
202:
196:
192:
188:
183:
179:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
130:
122:
117:
110:
105:
100:
89:
87:
83:
79:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2476:expanding it
2468:chromosome 3
2461:
2415:
2411:
2380:
2376:
2345:
2341:
2304:
2300:
2272:
2268:
2239:
2235:
2200:
2196:
2165:
2161:
2122:
2118:
2079:
2075:
2038:
2034:
1999:
1995:
1966:
1962:
1940:(1): 42–50.
1937:
1933:
1897:
1893:
1835:
1831:
1821:
1809:. Retrieved
1805:
1796:
1763:
1759:
1753:
1710:
1706:
1696:
1653:
1649:
1639:
1602:
1598:
1588:
1555:
1551:
1545:
1510:
1506:
1496:
1461:
1457:
1447:
1412:
1408:
1398:
1361:
1357:
1347:
1333:
1308:
1304:
1298:
1289:
1280:
1271:
1262:
1191:
1167:
1141:
1133:
1132:
1054:NP_001152841
1051:
1030:
1003:NM_001159369
1000:
975:
951:
932:
906:
887:
861:
842:
822:
817:
504:spermatocyte
404:
397:
262:121,545,988
249:121,431,431
124:External IDs
67:
2041:(1): 9–16.
1464:(1): 3216.
1311:(1): 90–6.
1174:nucleotides
687:nucleoplasm
661:ATP binding
616:DNA binding
442:bone marrow
363:36,915,779
350:36,832,148
102:Identifiers
2515:Categories
2236:DNA Repair
1257:, May 2017
1236:, May 2017
1212:References
1194:DNA repair
1151:(NHEJ) or
753:DNA repair
692:chromosome
524:blastocyst
408:(ortholog)
145:HomoloGene
2466:on human
2418:(1): 89.
1788:195892718
1580:195892718
1170:mutagenic
1058:NP_084253
1033:NP_955452
1007:NM_029977
982:NM_006596
978:NM_199420
808:Orthologs
702:cytoplasm
153:GeneCards
2442:17353931
2399:17150533
2364:16835218
2329:32695133
2321:16824193
2291:16603639
2256:16520097
2227:16222339
2184:16188888
2149:15496986
2106:15342556
2063:19912440
2055:14735462
2026:14576298
1983:12051913
1934:Genomics
1924:22135286
1870:34117057
1806:phys.org
1780:31296341
1745:25642963
1688:25642960
1631:25275444
1572:31296341
1537:24614976
1488:24496117
1439:20460465
1390:20617203
1325:10395804
1305:Genomics
1253:–
1232:–
1106:Wikidata
787:Sources:
512:yolk sac
434:testicle
2433:1847948
2218:1276717
1954:7829101
1915:3315306
1861:8195485
1840:Bibcode
1811:10 July
1736:4415602
1715:Bibcode
1679:4718306
1658:Bibcode
1622:4183433
1528:4032859
1466:Bibcode
1430:2943611
1381:2895639
1255:Ensembl
1234:Ensembl
920:UniProt
875:Ensembl
814:Species
793:QuickGO
697:nucleus
383:pattern
241:3q13.33
141:2155399
109:Aliases
2440:
2430:
2397:
2362:
2327:
2319:
2289:
2254:
2225:
2215:
2182:
2147:
2140:526458
2137:
2104:
2097:515316
2094:
2061:
2053:
2024:
2017:275456
2014:
1981:
1952:
1922:
1912:
1868:
1858:
1786:
1778:
1743:
1733:
1707:Nature
1686:
1676:
1650:Nature
1629:
1619:
1578:
1570:
1535:
1525:
1486:
1437:
1427:
1388:
1378:
1323:
1182:insert
1138:enzyme
1136:is an
1092:search
1090:PubMed
953:Q8CGS6
934:O75417
830:Entrez
554:BioGPS
520:zygote
516:embryo
500:morula
133:604419
2470:is a
2325:S2CID
2059:S2CID
1784:S2CID
1576:S2CID
863:77782
844:10721
823:Mouse
818:Human
789:Amigo
406:Mouse
399:Human
346:Start
281:Mouse
245:Start
178:Human
149:32727
2472:stub
2464:gene
2438:PMID
2395:PMID
2360:PMID
2317:PMID
2287:PMID
2252:PMID
2223:PMID
2180:PMID
2145:PMID
2102:PMID
2051:PMID
2022:PMID
1979:PMID
1950:PMID
1920:PMID
1866:PMID
1813:2021
1776:PMID
1741:PMID
1684:PMID
1627:PMID
1568:PMID
1533:PMID
1484:PMID
1435:PMID
1386:PMID
1321:PMID
1145:gene
1142:POLQ
389:Bgee
337:Band
298:Chr.
236:Band
195:Chr.
157:POLQ
129:OMIM
116:POLQ
86:5A9F
82:5A9J
78:5AGA
74:4X0Q
70:4X0P
51:RCSB
48:PDBe
22:POLQ
2428:PMC
2420:doi
2385:doi
2350:doi
2346:281
2309:doi
2277:doi
2244:doi
2213:PMC
2205:doi
2170:doi
2166:280
2135:PMC
2127:doi
2092:PMC
2084:doi
2043:doi
2039:109
2012:PMC
2004:doi
1971:doi
1967:319
1942:doi
1910:PMC
1902:doi
1856:PMC
1848:doi
1768:doi
1731:PMC
1723:doi
1711:518
1674:PMC
1666:doi
1654:518
1617:PMC
1607:doi
1560:doi
1523:PMC
1515:doi
1474:doi
1425:PMC
1417:doi
1376:PMC
1366:doi
1313:doi
1206:DNA
1202:RNA
359:End
258:End
161:OMA
137:MGI
41:PDB
2517::
2436:.
2426:.
2414:.
2410:.
2393:.
2381:48
2379:.
2375:.
2358:.
2344:.
2340:.
2323:.
2315:.
2305:11
2303:.
2285:.
2271:.
2267:.
2250:.
2238:.
2221:.
2211:.
2201:24
2199:.
2195:.
2178:.
2164:.
2160:.
2143:.
2133:.
2123:23
2121:.
2117:.
2100:.
2090:.
2080:14
2078:.
2074:.
2057:.
2049:.
2037:.
2020:.
2010:.
2000:31
1998:.
1994:.
1977:.
1965:.
1948:.
1938:23
1936:.
1918:.
1908:.
1898:40
1896:.
1892:.
1864:.
1854:.
1846:.
1834:.
1830:.
1804:.
1782:.
1774:.
1764:35
1762:.
1739:.
1729:.
1721:.
1709:.
1705:.
1682:.
1672:.
1664:.
1652:.
1648:.
1625:.
1615:.
1603:10
1601:.
1597:.
1574:.
1566:.
1556:35
1554:.
1531:.
1521:.
1511:24
1509:.
1505:.
1482:.
1472:.
1460:.
1456:.
1433:.
1423:.
1413:38
1411:.
1407:.
1384:.
1374:.
1360:.
1356:.
1319:.
1309:59
1307:.
1288:.
1270:.
1241:^
1220:^
1208:.
1157:Ku
791:/
365:bp
352:bp
264:bp
251:bp
159:;
155::
151:;
147::
143:;
139::
135:;
131::
84:,
80:,
76:,
72:,
2503:e
2496:t
2489:v
2478:.
2444:.
2422::
2416:3
2401:.
2387::
2366:.
2352::
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2311::
2293:.
2279::
2273:4
2258:.
2246::
2240:5
2229:.
2207::
2186:.
2172::
2151:.
2129::
2108:.
2086::
2065:.
2045::
2028:.
2006::
1985:.
1973::
1956:.
1944::
1926:.
1904::
1872:.
1850::
1842::
1836:7
1815:.
1790:.
1770::
1747:.
1725::
1717::
1690:.
1668::
1660::
1633:.
1609::
1582:.
1562::
1539:.
1517::
1490:.
1476::
1468::
1462:5
1441:.
1419::
1392:.
1368::
1362:6
1341:.
1327:.
1315::
1292:.
1274:.
283:)
180:)
163::
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