1195:
mg/kg) when administered to pregnant rats and rabbits, respectively. Additional studies in rats with oral doses up to 360 mg/kg/day (five times the recommended maximum human dose based on mg/m2 or 23 times based on mg/kg) demonstrated no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. Doses equivalent to 50 and 10 times the recommended maximum human dose of ofloxacin (based on mg/kg) were fetotoxic (i.e., decreased fetal body weight and increased fetal mortality) in rats and rabbits, respectively. Minor skeletal variations were reported in rats receiving doses of 810 mg/kg/day, which is more than 10 times higher than the recommended maximum human dose based on mg/m.
521:
498:
38:
1378:, obtained FDA approval in December 1990, under the brand name Floxin, labelled for use in adults with lower respiratory tract infections, skin and skin structure infections, urinary tract infections, prostatitis, and sexually transmitted diseases. By 1991, it was also marketed as Tarvid by Hoechst in the UK, Germany, Belgium, and Portugal; as Oflocet in France, Portugal, Tunisia, and several African countries by Roussel-Uclaf, as Oflocin by Glaxo in Italy, and as Flobacin by Sigma-Tau in Italy.
1258:
1107:-associated diarrhea may occur in connection with the use of any antibacterial drug, especially those with a broad spectrum of activity such as clindamycin, cephalosporins, and fluoroquinolones. Fluoroquinoline treatment is associated with risk similar to or less than that associated with broad spectrum cephalosporins. Fluoroquinoline administration may be associated with the acquisition and outgrowth of a particularly virulent
1207:
musculoskeletal events occurring up to 12 months after treatment. At 12 months' follow-up, the cumulative incidence of musculoskeletal adverse events was 3.4%, compared to 1.8% among 893 patients treated with other antibiotics. In the levafloxacin-treated group, about two-thirds of these musculoskeletal adverse events occurred in the first 60 days, 86% were mild, 17% were moderate, and all resolved without long-term sequelae.
1316:, approximately 32% of the drug in plasma is protein bound. Floxin is widely distributed to body tissues. Ofloxacin has been detected in blister fluid, cervix, lung tissue, ovary, prostatic fluid, prostatic tissue, skin, and sputum. Pyridobenzoxazine ring appears to decrease the extent of parent compound metabolism. Less than 5% is eliminated by the kidneys as desmethyl or N-oxide metabolites; 4% to 8% by feces."
29:
6943:
1086:
disability is possible, and is more likely in older patients. The overall frequency of fluoroquinolone-associated
Achilles tendon rupture in patients treated with ciprofloxacin or levofloxacin has been estimated at 17 per 100,000 treatments. Risk is substantially elevated in the elderly and in those with recent exposure to topical or systemic corticosteroid therapy. Simultaneous use of
1219:
observed in the levofloxacin group, neither of which was thought to be treatment-related. Spontaneous reports to the FDA Adverse
Effects Reporting System at the time of the 20 September 2011 FDA Pediatric Drugs Advisory Committee include musculoskeletal events (39, including five cases of tendon rupture) and
3545:
1281:
of ofloxacin in the tablet form is roughly 98% following oral administration, reaching maximum serum concentrations within one to two hours. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Therefore, elimination is mainly
1052:
The overall rate of adverse events in patients treated with fluoroquinolones is roughly similar to that seen in patients treated with other antibiotic classes. A U.S. Centers for
Disease Control study found patients treated with fluoroquinolones experienced adverse events severe enough to lead to an
1194:
Ofloxacin has not been shown to have any teratogenic effects at oral doses as high as 810 mg/kg/day (11 times the recommended maximum human dose based on mg/m or 50 times based on mg/kg) and 160 mg/kg/day (four times the recommended maximum human dose based on mg/m or 10 times based on
1085:
are the subject of "black box" warnings in the United States. The most severe form of tendonopathy associated with fluoroquinolone administration is tendon rupture, which in the great majority of cases involves the
Achilles tendon. Younger people typically experience good recovery, but permanent
1114:
The US prescribing information contains a warning regarding uncommon cases of peripheral neuropathy, which can be permanent. Other nervous system effects include insomnia, restlessness, and rarely, seizure, convulsions, and psychosis Other rare and serious adverse events have been observed with
1232:
Limited information is available on overdose with ofloxacin. Advice for the management of an acute overdose of ofloxacin is emptying of the stomach, along with close observation, and making sure that the patient is appropriately hydrated. Hemodialysis or peritoneal dialysis is of only limited
1218:
in 712 children with community-acquired pneumonia, adverse events were experienced by 6% of those treated with levofloxacin and 4% of those treated with comparator antibiotics. Most of these adverse events were thought to be unrelated or doubtfully related to the levofloxacin. Two deaths were
1206:
Oral and intravenous ofloxacin are not licensed for use in children, except as noted above, due to the risk of musculoskeletal injury. In one study, 1534 juvenile patients (age 6 months to 16 years) treated with levofloxacin as part of three efficacy trials were followed up to assess all
1129:
Ofloxacin, like some other fluoroquinolones, may inhibit drug-metabolizing enzymes, and thereby increase blood levels of other drugs such as cyclosporine, theophylline, and warfarin, among others. These increased blood levels may result in a greater risk of side effects.
1481:(FDA), such as acute bronchitis, otitis media, and acute upper respiratory tract infection. Additionally they are commonly prescribed for medical conditions that are not even bacterial to begin with, such as viral infections, or those to which no proven benefit exists.
3562:
1080:
Postmarketing surveillance has revealed a variety of relatively rare but serious adverse effects associated with all members of the fluoroquinolone antibacterial class. Among these, tendon problems and exacerbation of the symptoms of the neurological disorder
1223:
events (19, including five cases of seizures) as the most common spontaneous reports between April 2005 and March 2008. An estimated 130,000 pediatric prescriptions for levofloxacin were filled on behalf of 112,000 pediatric patients during that period.
5972:
2058:
Falagas ME, Matthaiou DK, Vardakas KZ (December 2006). "Fluoroquinolones vs beta-lactams for empirical treatment of immunocompetent patients with skin and soft tissue infections: a meta-analysis of randomized controlled trials".
3570:
5791:
1178:. The excretion of ofloxacin may be reduced in patients with severe liver function disorders (e.g., cirrhosis with or without ascites). Ofloxacin is also considered to be contraindicated within the pediatric population,
6418:
5796:
1101:, a life-threatening arrhythmia, but in practice, this appears relatively uncommon in part because the most widely prescribed fluoroquinolones (ciprofloxacin and levofloxacin) only minimally prolong the QT interval.
6368:
5283:
3136:
Noel GJ, Bradley JS, Kauffman RE, Duffy CM, Gerbino PG, Arguedas A, et al. (October 2007). "Comparative safety profile of levofloxacin in 2523 children with a focus on four specific musculoskeletal disorders".
6529:
5308:
1410:, the levo-enantiomer of ofloxacin, in 1996; Johnson and Johnson's annual sales of Floxin in 2003 was about $ 30 million, whereas their combined sales of Levaquin/Floxin exceeded $ 1.15 billion in the same year.
6521:
6448:
6423:
1427:
Ofloxacin for systemic use is available in multiple strengths as a tablet, an oral suspension, and an injectable solution. It is also used as eye drops and ear drops and is available in combination with
1476:
Floxacin and other fluoroquinolones had become the most commonly prescribed class of antibiotics to adults in 2002. Nearly half (42%) of these prescriptions were for conditions not approved by the U.S.
5841:
2606:
Galatti L, Giustini SE, Sessa A, Polimeni G, Salvo F, Spina E, Caputi AP (March 2005). "Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy".
6963:
6491:
1136:
The concomitant administration of a nonsteroidal anti-inflammatory drug with a quinolone, including ofloxacin, may increase the risk of central nervous system stimulation and convulsive seizures.
6428:
5322:
1319:
A number of the endogenous compounds have been reported to be affected by ofloxacin as inhibitors, alteraters, and depletors. See the latest package insert for ofloxacin for additional details.
1198:
There are, however, no adequate and well-controlled studies in pregnant women. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
6433:
1162:
Current or past treatment with oral corticosteroids is associated with an increased risk of
Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
5836:
5831:
3703:
3251:
Amsden GW, Graci DM, Cabelus LJ, Hejmanowski LG (July 1999). "A randomized, crossover design study of the pharmacology of extended-spectrum fluoroquinolones for pneumococcal infections".
5826:
5821:
6438:
6413:
2585:"FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection"
1381:
The market for ofloxacin was seen as difficult from its launch; it was approved as a "1C" drug, a new molecular entity with little or no therapeutic gain over existing therapies, and
3641:
883:
Fluoroquinolones, the class of drug ofloxacin belongs to, were the drug of choice for treating gonorrhea in the 1980s; However, due to the development of fluoroquinolone-resistant
2839:
6215:
6230:
2094:
Van
Bambeke F, Tulkens PM (2009). "Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes".
1090:
is present in almost one-third of quinolone-associated tendon rupture. Tendon damage may manifest during and up to a year after fluoroquinolone therapy has been completed.
6496:
6363:
5278:
5248:
889:, fluoroquinolones were no longer used to treat gonorrhea by the late 1990s. As of 2004, the failure of single dose ofloxacin to treat gonorrhea has been reported in the
4219:
6443:
3023:
Coban S, Ceydilek B, Ekiz F, Erden E, Soykan I (October 2005). "Levofloxacin-induced acute fulminant hepatic failure in a patient with chronic hepatitis B infection".
6476:
1351:. Topoisomerase IV is an enzyme necessary to separate (mostly in prokaryotes, in bacteria in particular) replicated DNA, thereby inhibiting bacterial cell division.
593:
4214:
3667:
3563:"Johnson & Johnson Going Into 1991 With At Least Four New Product Launches: Floxin, Vascor, Procrit And Duragesic; J&J Leading Off With Procrit, Vascor"
3180:
1374:
It was first approved for marketing in Japan in 1985, for oral administration, and
Daiichi marketed it there under the brand name Tarvid. Daiichi, working with
7013:
6993:
4015:
2897:
1312:"After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 and 3.6 μg/ml, respectively, are predicted at steady-state.
6845:
6516:
6461:
5113:
2519:
1995:
167:
1249:
toxicity as well as kidney failure and seizure. Both seizures and severe psychiatric reactions have, however, been reported to occur at therapeutic dosage.
1133:
Careful monitoring of serum glucose is advised when ofloxacin or other fluorquinolones are used by people who are taking sulfonylurea antidiabetes drugs.
5726:
6310:
5032:
6919:
6315:
5962:
5922:
5118:
3861:
3519:
6973:
5656:
6175:
3710:
3543:, Hayakawa I, Hiramitsu T, Tanaka Y, "Benzoxazine derivatives", issued 10 May 1983, assigned to Daiichi Pharmaceutical Co. Ltd.
4164:
3794:
3208:
Hall CE, Keegan H, Rogstad KE (September 2003). "Psychiatric side effects of ofloxacin used in the treatment of pelvic inflammatory disease".
1174:
for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance. Caution should be used in people with
6880:
5178:
5168:
2219:
Sode J, Obel N, Hallas J, Lassen A (May 2007). "Use of fluroquinolone and risk of
Achilles tendon rupture: a population-based cohort study".
74:
3633:
5982:
5746:
3290:
629:
3808:
Linder JA, Huang ES, Steinman MA, Gonzales R, Stafford RS (March 2005). "Fluoroquinolone prescribing in the United States: 1995 to 2002".
1781:
Bodoev IN, Il'Ina EN (July 2015). "Molecular mechanisms of formation of drug resistance in
Neisseria gonorrhoeae: History and prospects".
6908:
6840:
6835:
6830:
6825:
6820:
6785:
6456:
6200:
3427:
2997:
2957:"Increased risk of achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids"
2823:
1647:
6795:
6670:
6511:
6506:
6240:
6076:
5771:
5158:
5153:
5128:
736:
657:
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
1049:
occur. Common side effects include gastrointestinal effects such as nausea, vomiting, and diarrhea, as well as headache and insomnia.
7018:
5992:
5751:
1126:. Susceptible groups of patients, such as children and the elderly, are at greater risk of adverse reactions during therapeutic use.
3735:"Novartis Pharmaceuticals Corp. et al.; Withdrawal of Approval of 92 New Drug Applications and 49 Abbreviated New Drug Applications"
6800:
3520:"LEVAQUIN Ortho-McNeil Pharmaceutical, Inc. v. Lupin Pharmaceutical, Inc. C.A. No. 06-04999-GEB-TJB May 1, 2009 Memorandum Opinion"
3311:
3738:
3110:
2584:
1755:
5025:
4813:
4757:
3854:
3483:
3421:
2833:
1697:
806:
782:
6280:
2686:"[Clinically significant toxicity and tolerance of the main antibiotics used in lower respiratory tract infections]"
1608:
1515:
6988:
3968:
754:
When taken by mouth, common side effects include vomiting, diarrhea, headache, and rash. Other serious side effect include
1273:-ofloxacin (bottom). Only levofloxacin is biologically active, and is thus solely responsible for the effects of the drug.
6345:
3191:
1036:
303:)-7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclotrideca-5(13),6,8,11-tetraene-11-carboxylic acid
2853:
Iannini PB (June 2007). "The safety profile of moxifloxacin and other fluoroquinolones in special patient populations".
6978:
3663:
6398:
5018:
3913:
3347:
1641:
1584:
1548:
1045:
In general, fluoroquinolones are well tolerated, with most side effects being mild to moderate. On occasion, serious
674:
649:
125:
6606:
5064:
2912:
4774:
4057:
3847:
728:
2941:
2529:
2480:"Antibiotics and hospital-acquired Clostridium difficile infection: update of systematic review and meta-analysis"
2003:
1960:
De Sarro A, De Sarro G (March 2001). "Adverse reactions to fluoroquinolones. an overview on mechanistic aspects".
291:
217:
106:
3586:"Bioequivalence of oral and intravenous ofloxacin after multiple-dose administration to healthy male volunteers"
1151:. Additionally, the risk of cardiotoxicity and arrhythmias is increased when co-administered with drugs such as
6250:
5952:
4646:
1286:
excretion. However, 4-8% of an ofloxacin dose is excreted in the feces. This would indicate a small degree of
6578:
4463:
4349:
4204:
1360:
4415:
4292:
3978:
2545:"Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis"
2180:"The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture: What Does The Clinician Need To Know?"
6998:
6901:
4693:
4085:
3681:
3187:
2908:
2588:
2524:
2019:"Macrolides vs. quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials"
1999:
1478:
1396:
516:
397:
4535:
3530:
2339:
2303:
Khaliq Y, Zhanel GG (October 2005). "Musculoskeletal injury associated with fluoroquinolone antibiotics".
6305:
1392:
847:
477:
3839:
1453:
to ofloxacin and other fluoroquinolones may evolve rapidly, even during a course of treatment. Numerous
6933:
1824:
Dan M (April 2004). "The use of fluoroquinolones in gonorrhoea: the increasing problem of resistance".
789:. In 2021, it was the 240th most commonly prescribed medication in the United States, with more than 1
6695:
6685:
6111:
5055:
4806:
1661:
1564:
1328:
6539:
466:
4209:
2955:
van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HM, Rowlands S, Stricker BH (August 2003).
933:
859:
712:
493:
6983:
6665:
6320:
5123:
4849:
4762:
4270:
2437:
Deshpande A, Pasupuleti V, Thota P, Pant C, Rolston DD, Sferra TJ, et al. (September 2013).
136:
50:
6690:
3286:
3070:
7008:
6968:
6086:
5947:
5681:
4957:
4118:
3963:
3874:
1469:
1234:
1220:
1011:
983:
969:
945:
260:
3411:
1631:
913:
According to the product package insert, ofloxacin is effective against these microorganisms:
5927:
4041:
4037:
3921:
3001:
1459:
1450:
1445:
1340:
1291:
1023:
997:
990:
921:
885:
604:
446:
7003:
6650:
6170:
5806:
5317:
4854:
4799:
4791:
4340:
4264:
3699:
2340:"[Rupture of the patellar ligament one month after treatment with fluoroquinolone]"
1411:
1375:
1040:
688:
406:
321:
270:
2905:
Public Health
Service Food and Drug Administration Center for Drug Evaluation and Research
1097:
by blocking voltage-gated potassium channels. Prolongation of the QT interval can lead to
386:
8:
6700:
6680:
6164:
5801:
5505:
5327:
5218:
4858:
4390:
724:
696:
692:
312:
147:
143:
2369:
Heidelbaugh JJ, Holmstrom H (April 2013). "The perils of prescribing fluoroquinolones".
520:
497:
5889:
5561:
5523:
5047:
4641:
4113:
3788:
3318:
3233:
3162:
3048:
2878:
2794:
2769:
2750:
2666:
2439:"Community-associated Clostridium difficile infection and antibiotics: a meta-analysis"
2244:
2196:
2179:
2119:
1849:
1806:
957:
786:
3734:
3610:
3585:
3387:
3362:
2543:
Vardakas KZ, Konstantelias AA, Loizidis G, Rafailidis PI, Falagas ME (November 2012).
1893:
1868:
37:
6810:
6481:
6142:
5533:
5380:
5335:
5173:
4894:
3897:
3825:
3615:
3461:
3457:
3417:
3392:
3268:
3225:
3154:
3092:
3066:
3065:
Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy Print
3040:
2978:
2870:
2829:
2799:
2742:
2707:
2658:
2623:
2592:
2566:
2501:
2460:
2419:
2378:
2351:
2320:
2285:
2236:
2201:
2160:
2111:
2107:
2076:
2040:
2035:
2018:
1977:
1942:
1898:
1841:
1810:
1798:
1637:
1580:
1544:
1082:
1004:
748:
232:
98:
3166:
3052:
2882:
2754:
2670:
2123:
6635:
6388:
6046:
5846:
5776:
5611:
5509:
5341:
5222:
4386:
4093:
4065:
3817:
3605:
3597:
3453:
3382:
3378:
3374:
3260:
3237:
3217:
3146:
3032:
2968:
2862:
2789:
2781:
2734:
2697:
2650:
2615:
2556:
2491:
2450:
2409:
2312:
2275:
2248:
2228:
2191:
2150:
2103:
2068:
2030:
1969:
1932:
1888:
1880:
1867:
Sato K, Matsuura Y, Inoue M, Une T, Osada Y, Ogawa H, Mitsuhashi S (October 1982).
1853:
1833:
1790:
1669:
1572:
1441:
1348:
1152:
976:
720:
533:
242:
200:
190:
180:
3494:
2898:"Consult: One-Year Post Pediatric Exclusivity Postmarketing Adverse Events Review"
1689:
781:
Ofloxacin was patented in 1980 and approved for medical use in 1985. It is on the
6947:
6147:
6056:
6021:
5689:
5671:
5596:
5553:
5416:
4869:
4282:
4108:
3821:
3150:
2973:
2956:
2702:
2685:
1719:
1600:
1511:
1278:
1171:
1087:
771:
609:
346:
250:
84:
3882:
3878:
2822:
Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA (2006).
2725:
Mehlhorn AJ, Brown DA (November 2007). "Safety concerns with fluoroquinolones".
6730:
6625:
5675:
5545:
5440:
5366:
5331:
4962:
4939:
4768:
4655:
4525:
4325:
4320:
4310:
4174:
4169:
4133:
3991:
3221:
2619:
2561:
2544:
1368:
1238:
1119:
1046:
894:
755:
5537:
2316:
2232:
2017:
Skalsky K, Yahav D, Lador A, Eliakim-Raz N, Leibovici L, Paul M (April 2013).
1794:
6957:
6640:
6330:
6137:
6025:
6006:
5942:
5869:
5781:
5731:
5697:
5660:
5621:
5571:
5411:
5406:
5396:
5360:
5263:
5198:
5148:
5097:
5041:
4952:
4947:
4909:
4879:
4874:
4623:
4573:
4563:
4521:
4511:
4501:
4433:
4357:
4315:
4235:
4159:
4128:
4047:
4033:
4021:
4011:
4005:
4001:
3996:
3986:
3941:
2866:
2785:
2654:
1973:
1837:
1802:
1382:
1336:
1332:
1294:
is around 4 to 5 hours in patients and 6.4 to 7.4 hours in elderly patients.
1175:
1140:
1139:
The fluoroquinolones have been shown to increase the anticoagulant effect of
1054:
890:
616:
509:
3264:
3129:
1182:, nursing mothers, patients with psychiatric illnesses and in patients with
6597:
6568:
6562:
6373:
6160:
6123:
6119:
6041:
5937:
5625:
5600:
5576:
5298:
5103:
5010:
4967:
4929:
4827:
4578:
4568:
4553:
4543:
4516:
4496:
4491:
4486:
4481:
4476:
4471:
4453:
4448:
4443:
4438:
4428:
4423:
4382:
4377:
4179:
4070:
3951:
3829:
3540:
3465:
3343:
3272:
3229:
3158:
3096:
3044:
2982:
2874:
2746:
2711:
2662:
2627:
2570:
2505:
2464:
2423:
2414:
2397:
2382:
2355:
2324:
2289:
2240:
2205:
2164:
2115:
2080:
2044:
1981:
1946:
1845:
1666:
World Health Organization model list of essential medicines: 21st list 2019
1407:
1400:
1302:
1211:
831:
744:
195:
185:
175:
6605:
3682:"Teva Announces Approval of Ofloxacin Tablets, 200 mg, 300 mg, and 400 mg"
3619:
3601:
3396:
2803:
1902:
1543:(69 ed.). British Medical Association. 2015. pp. 409, 757, 782.
20:
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6245:
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92:
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1257:
1210:
In a study comparing the safety and efficacy of levofloxacin to that of
366:
6735:
6645:
6554:
6544:
6403:
6220:
6210:
6195:
6190:
6185:
6152:
6131:
6101:
6036:
6016:
6010:
5912:
5879:
5873:
5865:
5766:
5761:
5756:
5741:
5693:
5666:
5631:
5606:
5465:
5460:
5454:
5401:
5350:
5346:
5233:
5088:
4981:
4899:
4889:
4884:
4864:
4701:
4627:
4614:
4603:
4548:
4405:
4400:
4372:
4305:
4275:
4123:
3936:
3891:
2937:
2542:
2338:
Saint F, Gueguen G, Biserte J, Fontaine C, Mazeman E (September 2000).
2072:
1576:
1429:
1344:
1306:
1262:
1074:
1062:
938:
826:
822:
708:
569:
377:
3036:
2738:
2139:"Emergency department visits for antibiotic-associated adverse events"
1170:
As noted above, under licensed use, ofloxacin is now considered to be
6870:
6865:
6855:
6815:
6760:
6745:
6725:
6720:
6705:
6501:
6471:
6378:
6358:
6353:
6205:
6127:
6061:
6031:
6002:
5932:
5917:
5884:
5851:
5615:
5591:
5549:
5541:
5500:
5490:
5474:
5470:
5446:
5431:
5426:
5386:
5303:
5288:
5253:
5243:
5228:
5203:
5183:
5138:
4999:
4989:
4977:
4924:
4836:
4823:
4721:
4716:
4706:
4688:
4330:
4300:
4250:
4103:
4026:
3781:
International Symposium on Antimicrobial Agents and Resistance. Drugs
3529:. Fish & RichaRdson P.C. April 2009. p. VIII. Archived from
1399:(FDA) for the oral formulation, and in the same year, a solution for
1305:(the biologically active component) and 50% of its “mirror image” or
1242:
1179:
1156:
1148:
1058:
902:
870:
813:
767:
763:
704:
332:
78:
64:(±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7
3779:
Jacobs M (2005). "Worldwide overview of antimicrobial Resistance.".
1914:
1912:
1869:"In vitro and in vivo activity of DL-8280, a new oxazine derivative"
1406:
Daiichi and J&J also cannibalized its own market by introducing
801:
Ofloxacin is used in the treatment of bacterial infections such as:
774:
family of medications. It works by interfering with the bacterium's
6860:
6790:
6780:
6740:
6715:
6655:
6558:
6466:
6340:
6270:
6225:
6156:
6096:
6081:
5996:
5957:
5856:
5736:
5645:
5585:
5565:
5557:
5450:
5436:
5420:
5370:
5268:
5258:
5238:
5208:
5192:
5083:
4904:
4367:
4154:
3931:
3484:"Research and Development of Quinolones in Daiichi Sankyo Co., Ltd"
2344:
Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur
2280:
2263:
2155:
2138:
1937:
1920:
1454:
1183:
1053:
emergency department visit more frequently than those treated with
877:
853:
759:
740:
732:
426:
357:
159:
155:
120:
592:
6765:
6750:
6660:
6573:
6300:
6260:
6255:
6180:
6091:
6071:
5987:
5636:
5376:
5292:
5273:
5108:
4994:
4240:
3539:
1909:
1298:
1287:
1246:
1123:
876:
Ofloxacin has not been shown to be effective in the treatment of
837:
151:
6964:
1,4-di-hydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic acids
5816:
5811:
2821:
2641:
Babar SM (October 2013). "SIADH associated with ciprofloxacin".
6630:
5581:
5484:
5188:
3073:
Volume: 25 | Issue: 1 Cover date: January 2005 Page(s): 116–118
2137:
Shehab N, Patel PR, Srinivasan A, Budnitz DS (September 2008).
898:
841:
457:
1118:
Events that may occur in acute overdose are rare, and include
6675:
6325:
6051:
5901:
5517:
5133:
3250:
1388:
By 1992, an intravenous solution was approved for marketing,
1283:
727:. Other uses, along with other medications, include treating
583:
437:
4821:
2605:
2436:
2136:
2016:
482:
28:
6770:
6583:
6265:
6235:
5977:
5967:
5907:
5897:
5893:
5480:
3807:
2337:
1385:, which had a broader spectrum, was already on the market.
417:
6281:
3082:
1435:
5685:
4678:
4654:
2998:"DOHMH ALERT #8:Fluoroquinolone-resistant gonorrhea, NYC"
1660:
1563:
775:
3135:
2057:
1678:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
3312:"Ortho-McNeill, Johnson & Johnson, Daichi v. Mylan"
3083:
Nardiello S, Pizzella T, Ariviello R (March 2002). "".
783:
World Health Organization's List of Essential Medicines
6607:
5065:
3022:
3000:. USA: New York County Medical Society. Archived from
2520:"Data Mining Analysis of Multiple Antibiotics in AERS"
1996:"Data Mining Analysis of Multiple Antibiotics in AERS"
6931:
3737:. Federal Register 74(95):23407-23412. May 19, 2009.
3698:
1514:. The American Society of Health-System Pharmacists.
1367:, and was synthesized and developed by scientists at
3363:"DNA gyrase, topoisomerase IV, and the 4-quinolones"
3201:
2368:
2218:
1866:
1339:bacteria. It functions by inhibiting two bacterial
2093:
770:is typically not recommended. Ofloxacin is in the
3207:
2264:"Antimicrobial safety: focus on fluoroquinolones"
2184:The Journal of Clinical and Aesthetic Dermatology
1921:"Antimicrobial safety: focus on fluoroquinolones"
1750:
1748:
1746:
1744:
1742:
1740:
637:Fc4cc1c2N(/C=C(\C1=O)C(=O)O)C(COc2c4N3CCN(C)CC3)C
6955:
3244:
2995:
2828:. New York: McGraw-Hill, Medical Pub. Division.
1959:
1780:
818:Uncomplicated skin and skin structure infections
345:
3344:"Complete Ofloxacin information from Drugs.com"
3279:
3181:"Adverse Event Review: Levaquin (levofloxacin)"
1629:
1567:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
320:
2395:
1737:
1061:, but less frequently than those treated with
7014:World Health Organization essential medicines
6994:GABAA receptor negative allosteric modulators
5026:
4807:
3855:
3583:
3446:International Journal of Antimicrobial Agents
2724:
2477:
1783:Molecular Genetics, Microbiology and Virology
5040:
3801:
3111:"Levaquin- levofloxacin tablet, film coated"
2846:
2718:
2549:International Journal of Infectious Diseases
2331:
2302:
2296:
2261:
1953:
1918:
1817:
1601:"Ofloxacin Use During Pregnancy | Drugs.com"
1414:withdrew the marketing application in 2009.
124:
5042:
3477:
3475:
3443:
3403:
2938:"Showing drug card for Ofloxacin (DB01165)"
2930:
2817:
2815:
2813:
1860:
1265:of the ofloxacin molecule, levofloxacin or
1115:varying degrees of evidence for causation.
869:Acute, uncomplicated urethral and cervical
6290:Tooltip γ-Aminobutyric acid A-rho receptor
5033:
5019:
4814:
4800:
3862:
3848:
3793:: CS1 maint: location missing publisher (
3743:see also FDA docket number FDA-2009-N-0211
3367:Microbiology and Molecular Biology Reviews
3360:
2767:
2389:
1774:
1571:. World Health Organization. p. 140.
1506:
1504:
1502:
1500:
1498:
1496:
1494:
737:superficial bacterial infection of the eye
519:
496:
385:
3741:from the original on September 19, 2016.
3609:
3439:
3437:
3386:
2989:
2972:
2793:
2701:
2560:
2495:
2484:The Journal of Antimicrobial Chemotherapy
2454:
2443:The Journal of Antimicrobial Chemotherapy
2413:
2402:The Journal of Antimicrobial Chemotherapy
2279:
2221:European Journal of Clinical Pharmacology
2195:
2154:
2034:
1936:
1892:
1673:
405:
6974:Drugs developed by Johnson & Johnson
3640:. Floxin Tablets New FDA Drug Approval.
3584:Flor SC, Rogge MC, Chow AT (July 1993).
3472:
3139:The Pediatric Infectious Disease Journal
2810:
2677:
1256:
691:useful for the treatment of a number of
16:Antibiotic to treat bacterial infections
3557:
3555:
3444:Mouton Y, Leroy O (1991). "Ofloxacin".
3409:
3210:International Journal of STD & AIDS
2996:Blank S, Schillinger J (May 14, 2004).
2940:. Canada: DrugBank. February 19, 2009.
2895:
2852:
2683:
1535:
1533:
1491:
1436:Antibiotic use and bacterial resistance
1269:-ofloxacin (top) and dextrofloxacin or
908:
492:
365:
97:
6956:
6615:Tooltip γ-Aminobutyric acid B receptor
5073:Tooltip γ-Aminobutyric acid A receptor
3783:. Republic of Korea. pp. 542–546.
3778:
3434:
3430:from the original on 8 September 2017.
3416:. John Wiley & Sons. p. 295.
1654:
1636:. John Wiley & Sons. p. 500.
1623:
1557:
1417:
1233:effectiveness. Overdose may result in
916:Aerobic Gram-positive microorganisms:
510:
5014:
4795:
3843:
3590:Antimicrobial Agents and Chemotherapy
3341:
2640:
2634:
1873:Antimicrobial Agents and Chemotherapy
1668:. Geneva: World Health Organization.
1611:from the original on 28 December 2016
1518:from the original on 28 December 2016
1363:, being a broader-spectrum analog of
952:Aerobic Gram-negative microorganisms
807:chronic obstructive pulmonary disease
465:
445:
226:
115:
83:
6920:GABA metabolism/transport modulators
3704:"Building on a foundation of health"
3634:"Floxin Tablets (ofloxacin tablets)"
3552:
3481:
2855:Current Medical Research and Opinion
2398:"Cardiotoxicity of fluoroquinolones"
1700:from the original on 15 January 2024
1530:
1165:
199:
189:
179:
68:-pyridobenzoxazine-6-carboxylic acid
5316:Positive modulators (abridged; see
3664:"Floxin otic New FDA Drug Approval"
3644:from the original on April 13, 2016
3361:Drlica K, Zhao X (September 1997).
2825:Goldfrank's toxicologic emergencies
2478:Slimings C, Riley TV (April 2014).
2396:Rubinstein E, Camm J (April 2002).
2177:
2023:Clinical Microbiology and Infection
1823:
1720:"Ofloxacin - Drug Usage Statistics"
1252:
1041:Levofloxacin § Adverse effects
1037:Adverse effects of fluoroquinolones
425:
336:
13:
2944:from the original on May 14, 2016.
2262:Owens RC, Ambrose PG (July 2005).
1919:Owens RC, Ambrose PG (July 2005).
1541:British national formulary: BNF 69
1473:now exhibit resistance worldwide.
1422:
1030:
14:
7030:
6851:Homotaurine (tramiprosate, 3-APS)
6349:-Chloroacetylcytosine arabinoside
5144:Homotaurine (tramiprosate, 3-APS)
2770:"Quinolones may induce hepatitis"
2768:Jones SE, Smith RH (March 1997).
2690:Médecine et Maladies Infectieuses
1826:Expert Opinion on Pharmacotherapy
1361:second-generation fluoroquinolone
1322:
805:Acute bacterial exacerbations of
621:250–257 °C (482–495 °F)
7019:4-Methylpiperazin-1-yl compounds
6941:
3810:The American Journal of Medicine
3670:from the original on 2016-08-27.
3569:. 7 January 1991. Archived from
3350:from the original on 2016-03-03.
2842:from the original on 2014-06-12.
2108:10.2165/00002018-200932050-00001
2036:10.1111/j.1469-0691.2012.03838.x
1650:from the original on 2016-12-29.
758:, numbness due to nerve damage,
729:multidrug resistant tuberculosis
553:
550:
544:
36:
27:
6143:Pentylenetetrazol (pentetrazol)
4822:Drugs used for diseases of the
3772:
3748:
3727:
3692:
3674:
3656:
3626:
3577:
3512:
3354:
3335:
3304:
3293:from the original on 2011-03-07
3173:
3103:
3076:
3059:
3016:
2948:
2889:
2761:
2599:
2577:
2536:
2512:
2471:
2430:
2362:
2255:
2212:
2171:
2130:
2087:
2051:
2010:
1988:
1756:"Ofloxacin tablet, film coated"
1630:Fischer J, Ganellin CR (2006).
1301:mixture, which consists of 50%
796:
662:Key:GSDSWSVVBLHKDQ-UHFFFAOYSA-N
3379:10.1128/mmbr.61.3.377-392.1997
2371:The Journal of Family Practice
1712:
1682:
1593:
1403:was approved under the brand
785:. Ofloxacin is available as a
559:
538:
1:
6902:Receptor/signaling modulators
6057:Isopregnanolone (sepranolone)
4205:Trimethoprim/sulfamethoxazole
3709:. Shareholder. Archived from
3410:Sneader W (31 October 2005).
3025:The Annals of Pharmacotherapy
2961:Archives of Internal Medicine
2727:The Annals of Pharmacotherapy
2643:The Annals of Pharmacotherapy
1633:Analogue-based Drug Discovery
1484:
1159:, and quinidine barbiturate.
1093:Fluoroquinolones prolong the
6913:receptor positive modulators
5421:ergoloid (dihydroergotoxine)
3822:10.1016/j.amjmed.2004.09.015
3458:10.1016/0924-8579(91)90001-T
3188:Food and Drug Administration
3151:10.1097/INF.0b013e3180cbd382
2974:10.1001/archinte.163.15.1801
2909:Food and Drug Administration
2703:10.1016/j.medmal.2006.05.012
2589:Food and Drug Administration
2525:Food and Drug Administration
2268:Clinical Infectious Diseases
2143:Clinical Infectious Diseases
2000:Food and Drug Administration
1925:Clinical Infectious Diseases
1479:Food and Drug Administration
1397:Food and Drug Administration
1331:that is active against both
1189:
1186:or other seizure disorders.
7:
6989:Fluoroquinolone antibiotics
4210:Ormetoprim/sulfadimethoxine
3287:"randomhouse author search"
2896:Farinas ER (1 March 2005).
1962:Current Medicinal Chemistry
1393:pelvic inflammatory disease
1391:In 1997, an indication for
1290:excretion, as well. Plasma
1227:
1201:
848:pelvic inflammatory disease
10:
7035:
6112:Nonsteroidal antiandrogens
3222:10.1258/095646203322301121
2684:Rouveix B (Nov–Dec 2006).
2620:10.1016/j.phrs.2004.08.003
2562:10.1016/j.ijid.2012.07.010
2305:Clinics in Plastic Surgery
1439:
1354:
1034:
528:Chemical and physical data
6979:Drugs developed by AbbVie
6893:
6596:
6279:
5063:
5054:
4976:
4938:
4835:
4752:
4730:
4687:
4677:
4640:
4612:
4591:
4534:
4462:
4414:
4348:
4339:
4291:
4263:
4228:
4220:Pyrimethamine/sulfadoxine
4197:
4147:
4084:
4056:
3977:
3962:
3912:
3890:
3413:Drug Discovery: A History
2317:10.1016/j.cps.2005.05.004
2233:10.1007/s00228-007-0265-9
1795:10.3103/S0891416815030027
1662:World Health Organization
1565:World Health Organization
1395:was approved by the U.S.
1329:broad-spectrum antibiotic
670:
645:
625:
615:
603:
581:
568:
532:
527:
508:
476:
456:
436:
416:
396:
376:
356:
331:
311:
287:
282:
269:
259:
249:
241:
216:
211:
166:
135:
105:
91:
73:
59:
49:
44:
35:
26:
5661:sulfonmethane (sulfonal)
3085:Le Infezioni in Medicina
2867:10.1185/030079907X188099
2786:10.1136/bmj.314.7084.869
2655:10.1177/1060028013502457
2608:Pharmacological Research
1974:10.2174/0929867013373435
1838:10.1517/14656566.5.4.829
1569:WHO Model Formulary 2008
934:Streptococcus pneumoniae
860:urinary tract infections
836:Mixed Infections of the
713:urinary tract infections
4850:Aluminium acetotartrate
3265:10.1378/chest.116.1.115
2061:Mayo Clinic Proceedings
793:million prescriptions.
723:, and certain types of
55:Floxin, Ocuflox, others
6540:5α-Dihydroprogesterone
6087:Morphine-3-glucuronide
5747:Hyenachin (mellitoxin)
5632:Retigabine (ezogabine)
4958:Fluocinolone acetonide
4119:Sulfamethoxypyridazine
2274:(Suppl 2): S144–S157.
1931:(Suppl 2): S144–S157.
1470:Streptococcus pyogenes
1341:type II topoisomerases
1274:
1235:central nervous system
1221:central nervous system
1018:Other microorganisms:
1012:Pseudomonas aeruginosa
984:Haemophilus influenzae
970:Enterobacter aerogenes
946:Streptococcus pyogenes
5928:Chlorophenylsilatrane
4592:Newer non-fluorinated
4229:Other DHPS inhibitors
4215:Pyrimethamine/dapsone
4042:Succinylsulfathiazole
4038:Phthalylsulfathiazole
3922:2,4-Diaminopyrimidine
3700:Johnson & Johnson
3602:10.1128/aac.37.7.1468
3190:(FDA). Archived from
2911:(FDA). Archived from
2591:(FDA). Archived from
2178:Kim GK (April 2010).
2002:(FDA). Archived from
1690:"The Top 300 of 2021"
1460:Staphylococcus aureus
1446:Antibiotic resistance
1412:Johnson & Johnson
1376:Johnson & Johnson
1292:elimination half-life
1260:
1105:Clostridium difficile
1024:Chlamydia trachomatis
998:Neisseria gonorrhoeae
991:Klebsiella pneumoniae
941:-susceptible strains)
929:-susceptible strains)
922:Staphylococcus aureus
886:Neisseria gonorrhoeae
701:injection into a vein
6878:Negative modulators:
6758:Positive modulators:
6651:Arbaclofen placarbil
6537:Negative modulators:
6386:Positive modulators:
6171:Pregnenolone sulfate
5807:17-Phenylandrostenol
5789:Negative modulators:
5674:constituents (e.g.,
5644:constituents (e.g.,
5506:Neuroactive steroids
5483:constituents (e.g.,
5219:Neuroactive steroids
4855:Aluminium triacetate
4016:Acetyl sulfisoxazole
3875:inhibit nucleic acid
3688:. September 2, 2003.
2415:10.1093/jac/49.4.593
1885:10.1128/aac.22.4.548
963:Citrobacter diversus
909:Susceptible bacteria
693:bacterial infections
689:quinolone antibiotic
6999:Ophthalmology drugs
6467:Gabazine (SR-95531)
6457:CGP-36742 (SGS-742)
6165:dihydropicrotoxinin
5890:Bicyclic phosphates
5802:11-Ketoprogesterone
5737:Gabazine (SR-95531)
5562:pyrazolopyrimidines
4391:Alalevonadifloxacin
4058:Intermediate-acting
1418:Society and culture
1099:torsades de pointes
812:Community-acquired
747:when a hole in the
725:infectious diarrhea
148:intravenous therapy
23:
5988:FG-7142 (ZK-31906)
5534:Nonbenzodiazepines
4779:Never to phase III
4280:thereby inhibiting
4268:(inhibit bacterial
4114:Sulfametoxydiazine
3902:thereby inhibiting
3895:(inhibit bacterial
3573:on 26 August 2016.
3500:on 12 October 2016
2918:on 21 October 2009
2696:(11–12): 697–705.
2497:10.1093/jac/dkt477
2456:10.1093/jac/dkt129
2311:(4): 495–502, vi.
2073:10.4065/81.12.1553
1762:. 4 September 2019
1275:
958:Citrobacter koseri
787:generic medication
735:may be used for a
19:
6929:
6928:
6889:
6888:
6811:2-Hydroxysaclofen
6592:
6591:
6482:Isonipecotic acid
5847:Anabolic steroids
5817:α5IA (LS-193,268)
5727:Dihydrosecurinine
5612:Pyrazolopyridines
5381:potassium bromide
5379:compounds (e.g.,
5342:Anabolic steroids
5320:for a full list):
5174:Isonipecotic acid
5008:
5007:
4895:Hydrogen peroxide
4789:
4788:
4748:
4747:
4673:
4672:
4636:
4635:
4587:
4586:
4259:
4258:
4193:
4192:
3898:purine metabolism
3423:978-0-470-01552-0
3037:10.1345/aph.1G111
3031:(10): 1737–1740.
2967:(15): 1801–1807.
2835:978-0-07-143763-9
2739:10.1345/aph.1K347
2733:(11): 1859–1866.
2649:(10): 1359–1363.
2555:(11): e768–e773.
2067:(12): 1553–1566.
1241:toxicity, tendon/
1166:Contraindications
1083:myasthenia gravis
1005:Proteus mirabilis
682:
681:
594:Interactive image
478:CompTox Dashboard
230:
118:
69:
7026:
6946:
6945:
6944:
6937:
6636:4-Fluorophenibut
6616:
6612:
6603:
6602:
6472:Gaboxadol (THIP)
6389:Allopregnanolone
6291:
6287:
6022:Fluoroquinolones
5777:Thiocolchicoside
5597:Piperidinediones
5554:imidazopyridines
5510:allopregnanolone
5417:Dihydroergolines
5332:drinking alcohol
5223:allopregnanolone
5139:Gaboxadol (THIP)
5074:
5070:
5061:
5060:
5044:
5035:
5028:
5021:
5012:
5011:
4859:Burow's solution
4816:
4809:
4802:
4793:
4792:
4685:
4684:
4652:
4651:
4387:Levonadifloxacin
4346:
4345:
4341:Fluoroquinolones
4289:
4288:
4094:Sulfadimethoxine
4066:Sulfamethoxazole
3987:Sulfaisodimidine
3975:
3974:
3910:
3909:
3864:
3857:
3850:
3841:
3840:
3834:
3833:
3805:
3799:
3798:
3792:
3784:
3776:
3770:
3769:
3767:
3766:
3752:
3746:
3745:
3731:
3725:
3724:
3722:
3721:
3715:
3708:
3696:
3690:
3689:
3678:
3672:
3671:
3660:
3654:
3653:
3651:
3649:
3630:
3624:
3623:
3613:
3596:(7): 1468–1472.
3581:
3575:
3574:
3559:
3550:
3549:
3548:
3544:
3537:
3535:
3524:
3516:
3510:
3509:
3507:
3505:
3499:
3493:. Archived from
3488:
3479:
3470:
3469:
3441:
3432:
3431:
3407:
3401:
3400:
3390:
3358:
3352:
3351:
3339:
3333:
3332:
3330:
3329:
3323:
3317:. Archived from
3316:
3308:
3302:
3301:
3299:
3298:
3283:
3277:
3276:
3248:
3242:
3241:
3205:
3199:
3198:
3196:
3185:
3177:
3171:
3170:
3133:
3127:
3126:
3124:
3122:
3107:
3101:
3100:
3080:
3074:
3063:
3057:
3056:
3020:
3014:
3013:
3011:
3009:
3004:on July 22, 2011
2993:
2987:
2986:
2976:
2952:
2946:
2945:
2934:
2928:
2927:
2925:
2923:
2917:
2902:
2893:
2887:
2886:
2861:(6): 1403–1413.
2850:
2844:
2843:
2819:
2808:
2807:
2797:
2765:
2759:
2758:
2722:
2716:
2715:
2705:
2681:
2675:
2674:
2638:
2632:
2631:
2603:
2597:
2596:
2581:
2575:
2574:
2564:
2540:
2534:
2533:
2528:. Archived from
2516:
2510:
2509:
2499:
2475:
2469:
2468:
2458:
2449:(9): 1951–1961.
2434:
2428:
2427:
2417:
2393:
2387:
2386:
2366:
2360:
2359:
2335:
2329:
2328:
2300:
2294:
2293:
2283:
2259:
2253:
2252:
2216:
2210:
2209:
2199:
2175:
2169:
2168:
2158:
2134:
2128:
2127:
2091:
2085:
2084:
2055:
2049:
2048:
2038:
2014:
2008:
2007:
1992:
1986:
1985:
1957:
1951:
1950:
1940:
1916:
1907:
1906:
1896:
1864:
1858:
1857:
1821:
1815:
1814:
1778:
1772:
1771:
1769:
1767:
1752:
1735:
1734:
1732:
1730:
1716:
1710:
1709:
1707:
1705:
1686:
1680:
1679:
1677:
1658:
1652:
1651:
1627:
1621:
1620:
1618:
1616:
1597:
1591:
1590:
1561:
1555:
1554:
1537:
1528:
1527:
1525:
1523:
1508:
1442:Antibiotic abuse
1349:topoisomerase IV
1309:dextrofloxacin.
1253:Pharmacokinetics
1153:dihydroquinidine
977:Escherichia coli
792:
743:may be used for
703:, these include
678:
677:
596:
576:
561:
555:
552:
546:
540:
523:
512:
501:
500:
486:
484:
469:
449:
429:
409:
389:
369:
349:
339:
338:
324:
274:
228:
225:
203:
193:
183:
128:
117:
114:
101:
87:
63:
40:
31:
24:
22:
18:
7034:
7033:
7029:
7028:
7027:
7025:
7024:
7023:
6954:
6953:
6952:
6942:
6940:
6932:
6930:
6925:
6912:
6885:
6614:
6611:
6588:
6316:Homohypotaurine
6289:
6285:
6275:
6148:Phenylsilatrane
5690:chloral hydrate
5657:Sulfonylalkanes
5546:cyclopyrrolones
5367:Benzodiazepines
5119:Dihydromuscimol
5072:
5069:
5050:
5039:
5009:
5004:
4972:
4940:Corticosteroids
4934:
4870:Chloramphenicol
4831:
4820:
4790:
4785:
4784:
4769:Clinical trials
4744:
4726:
4692:
4669:
4645:
4632:
4608:
4583:
4530:
4458:
4410:
4335:
4283:DNA replication
4281:
4279:
4273:
4269:
4267:
4255:
4224:
4189:
4148:Other/ungrouped
4143:
4109:Sulfametomidine
4080:
4052:
3966:
3958:
3905:
3903:
3901:
3896:
3894:
3886:
3868:
3838:
3837:
3806:
3802:
3786:
3785:
3777:
3773:
3764:
3762:
3760:go.drugbank.com
3754:
3753:
3749:
3733:
3732:
3728:
3719:
3717:
3713:
3706:
3697:
3693:
3680:
3679:
3675:
3662:
3661:
3657:
3647:
3645:
3632:
3631:
3627:
3582:
3578:
3561:
3560:
3553:
3546:
3533:
3522:
3518:
3517:
3513:
3503:
3501:
3497:
3486:
3480:
3473:
3442:
3435:
3424:
3408:
3404:
3359:
3355:
3340:
3336:
3327:
3325:
3321:
3314:
3310:
3309:
3305:
3296:
3294:
3285:
3284:
3280:
3249:
3245:
3206:
3202:
3194:
3183:
3179:
3178:
3174:
3145:(10): 879–891.
3134:
3130:
3120:
3118:
3109:
3108:
3104:
3081:
3077:
3064:
3060:
3021:
3017:
3007:
3005:
2994:
2990:
2953:
2949:
2936:
2935:
2931:
2921:
2919:
2915:
2900:
2894:
2890:
2851:
2847:
2836:
2820:
2811:
2766:
2762:
2723:
2719:
2682:
2678:
2639:
2635:
2604:
2600:
2583:
2582:
2578:
2541:
2537:
2518:
2517:
2513:
2476:
2472:
2435:
2431:
2394:
2390:
2367:
2363:
2336:
2332:
2301:
2297:
2260:
2256:
2217:
2213:
2176:
2172:
2135:
2131:
2092:
2088:
2056:
2052:
2015:
2011:
1994:
1993:
1989:
1958:
1954:
1917:
1910:
1865:
1861:
1822:
1818:
1779:
1775:
1765:
1763:
1754:
1753:
1738:
1728:
1726:
1718:
1717:
1713:
1703:
1701:
1688:
1687:
1683:
1659:
1655:
1644:
1628:
1624:
1614:
1612:
1599:
1598:
1594:
1587:
1562:
1558:
1551:
1539:
1538:
1531:
1521:
1519:
1510:
1509:
1492:
1487:
1448:
1438:
1425:
1423:Available forms
1420:
1369:Daiichi Seiyaku
1359:Ofloxacin is a
1357:
1327:Ofloxacin is a
1325:
1297:Ofloxacin is a
1279:bioavailability
1255:
1230:
1204:
1192:
1172:contraindicated
1168:
1088:corticosteroids
1047:adverse effects
1043:
1033:
1031:Adverse effects
911:
799:
790:
772:fluoroquinolone
673:
671:
666:
663:
658:
653:
652:
641:
638:
633:
632:
610:Racemic mixture
599:
574:
564:
558:
549:
543:
504:
480:
472:
452:
432:
412:
392:
372:
352:
335:
327:
307:
304:
295:
294:
272:
261:Protein binding
251:Bioavailability
243:Pharmacokinetic
237:
207:
138:
131:
17:
12:
11:
5:
7032:
7022:
7021:
7016:
7011:
7006:
7001:
6996:
6991:
6986:
6984:Daiichi Sankyo
6981:
6976:
6971:
6966:
6951:
6950:
6927:
6926:
6924:
6923:
6916:
6910:
6905:
6898:
6894:
6891:
6890:
6887:
6886:
6884:
6883:
6874:
6873:
6868:
6863:
6858:
6853:
6848:
6843:
6838:
6833:
6828:
6823:
6818:
6813:
6804:
6803:
6798:
6793:
6788:
6783:
6778:
6773:
6768:
6763:
6754:
6753:
6748:
6743:
6738:
6733:
6731:Sodium oxybate
6728:
6723:
6718:
6713:
6708:
6703:
6698:
6693:
6688:
6683:
6678:
6673:
6668:
6663:
6658:
6653:
6648:
6643:
6638:
6633:
6628:
6626:1,4-Butanediol
6619:
6617:
6609:
6600:
6594:
6593:
6590:
6589:
6587:
6586:
6581:
6576:
6571:
6566:
6552:
6547:
6542:
6533:
6532:
6527:
6519:
6514:
6509:
6504:
6499:
6494:
6489:
6484:
6479:
6474:
6469:
6464:
6459:
6454:
6446:
6441:
6436:
6431:
6426:
6421:
6416:
6407:
6406:
6401:
6396:
6391:
6382:
6381:
6376:
6371:
6366:
6361:
6356:
6351:
6343:
6338:
6333:
6328:
6323:
6318:
6313:
6308:
6303:
6294:
6292:
6283:
6277:
6276:
6274:
6273:
6268:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6178:
6173:
6168:
6150:
6145:
6140:
6135:
6109:
6104:
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6064:
6059:
6054:
6049:
6044:
6039:
6034:
6029:
6019:
6014:
6000:
5990:
5985:
5980:
5975:
5970:
5965:
5960:
5955:
5950:
5945:
5940:
5935:
5930:
5925:
5920:
5915:
5910:
5905:
5887:
5882:
5877:
5870:cephalosporins
5859:
5854:
5849:
5844:
5839:
5834:
5829:
5824:
5819:
5814:
5809:
5804:
5799:
5794:
5785:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5710:
5709:
5679:
5676:valerenic acid
5669:
5664:
5654:
5649:
5639:
5634:
5629:
5622:Quinazolinones
5619:
5609:
5604:
5594:
5589:
5579:
5574:
5569:
5531:
5526:
5521:
5503:
5498:
5493:
5488:
5478:
5468:
5463:
5458:
5444:
5441:mefenamic acid
5434:
5429:
5424:
5414:
5409:
5404:
5399:
5394:
5384:
5374:
5364:
5354:
5344:
5339:
5325:
5312:
5311:
5306:
5301:
5296:
5286:
5281:
5276:
5271:
5266:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5226:
5216:
5211:
5206:
5201:
5196:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5101:
5091:
5086:
5077:
5075:
5067:
5058:
5052:
5051:
5038:
5037:
5030:
5023:
5015:
5006:
5005:
5003:
5002:
4997:
4992:
4986:
4984:
4974:
4973:
4971:
4970:
4965:
4963:Hydrocortisone
4960:
4955:
4950:
4944:
4942:
4936:
4935:
4933:
4932:
4927:
4922:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4872:
4867:
4862:
4852:
4847:
4841:
4839:
4833:
4832:
4819:
4818:
4811:
4804:
4796:
4787:
4786:
4783:
4782:
4781:
4780:
4777:
4766:
4760:
4754:
4753:
4750:
4749:
4746:
4745:
4743:
4742:
4736:
4734:
4728:
4727:
4725:
4724:
4719:
4714:
4709:
4704:
4698:
4696:
4694:RNA polymerase
4682:
4675:
4674:
4671:
4670:
4668:
4667:
4661:
4659:
4656:Nitroimidazole
4649:
4638:
4637:
4634:
4633:
4631:
4630:
4624:Aminocoumarins
4620:
4618:
4610:
4609:
4607:
4606:
4601:
4595:
4593:
4589:
4588:
4585:
4584:
4582:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4546:
4540:
4538:
4532:
4531:
4529:
4528:
4526:Alatrofloxacin
4519:
4514:
4509:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4468:
4466:
4464:4th generation
4460:
4459:
4457:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4420:
4418:
4416:3rd generation
4412:
4411:
4409:
4408:
4403:
4398:
4393:
4380:
4375:
4370:
4365:
4360:
4354:
4352:
4350:2nd generation
4343:
4337:
4336:
4334:
4333:
4328:
4326:Piromidic acid
4323:
4321:Pipemidic acid
4318:
4313:
4311:Nalidixic acid
4308:
4303:
4297:
4295:
4293:1st generation
4286:
4261:
4260:
4257:
4256:
4254:
4253:
4248:
4243:
4238:
4232:
4230:
4226:
4225:
4223:
4222:
4217:
4212:
4207:
4201:
4199:
4195:
4194:
4191:
4190:
4188:
4187:
4182:
4177:
4175:Sulfaguanidine
4172:
4170:Sulfadicramide
4167:
4162:
4157:
4151:
4149:
4145:
4144:
4142:
4141:
4136:
4134:Sulfaphenazole
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4096:
4090:
4088:
4082:
4081:
4079:
4078:
4073:
4068:
4062:
4060:
4054:
4053:
4051:
4050:
4045:
4031:
4030:
4029:
4019:
4009:
3999:
3994:
3992:Sulfamethizole
3989:
3983:
3981:
3972:
3969:DHPS inhibitor
3960:
3959:
3957:
3956:
3955:
3954:
3949:
3944:
3939:
3934:
3929:
3918:
3916:
3914:DHFR inhibitor
3907:
3888:
3887:
3871:Antibacterials
3867:
3866:
3859:
3852:
3844:
3836:
3835:
3816:(3): 259–268.
3800:
3771:
3747:
3726:
3691:
3673:
3655:
3625:
3576:
3567:The Pink Sheet
3551:
3536:on 2016-08-27.
3511:
3471:
3452:(2–3): 57–74.
3433:
3422:
3402:
3373:(3): 377–392.
3353:
3334:
3303:
3278:
3259:(1): 115–119.
3243:
3216:(9): 636–637.
3200:
3197:on 2016-03-07.
3172:
3128:
3117:. 12 July 2019
3102:
3075:
3058:
3015:
2988:
2947:
2929:
2888:
2845:
2834:
2809:
2760:
2717:
2676:
2633:
2614:(3): 211–216.
2598:
2595:on 2016-05-28.
2576:
2535:
2532:on 2016-03-10.
2511:
2490:(4): 881–891.
2470:
2429:
2408:(4): 593–596.
2388:
2377:(4): 191–197.
2361:
2350:(5): 495–497.
2330:
2295:
2281:10.1086/428055
2254:
2227:(5): 499–503.
2211:
2170:
2156:10.1086/591126
2149:(6): 735–743.
2129:
2102:(5): 359–378.
2086:
2050:
2029:(4): 370–378.
2009:
2006:on 2016-03-10.
1987:
1968:(4): 371–384.
1952:
1938:10.1086/428055
1908:
1879:(4): 548–553.
1859:
1832:(4): 829–854.
1816:
1789:(3): 132–140.
1773:
1736:
1711:
1681:
1653:
1642:
1622:
1592:
1585:
1556:
1549:
1529:
1489:
1488:
1486:
1483:
1437:
1434:
1424:
1421:
1419:
1416:
1401:ear infections
1356:
1353:
1324:
1323:Mode of action
1321:
1254:
1251:
1245:toxicity, and
1239:cardiovascular
1229:
1226:
1203:
1200:
1191:
1188:
1167:
1164:
1120:kidney failure
1055:cephalosporins
1032:
1029:
1028:
1027:
1016:
1015:
1008:
1001:
994:
987:
980:
973:
966:
950:
949:
942:
930:
910:
907:
895:United Kingdom
874:
873:
867:
862:
856:
852:Uncomplicated
850:
844:
834:
829:
821:Nongonococcal
819:
816:
810:
798:
795:
756:tendon rupture
680:
679:
668:
667:
665:
664:
661:
659:
656:
648:
647:
646:
643:
642:
640:
639:
636:
628:
627:
626:
623:
622:
619:
613:
612:
607:
601:
600:
598:
597:
589:
587:
579:
578:
572:
566:
565:
562:
556:
547:
541:
536:
530:
529:
525:
524:
514:
506:
505:
503:
502:
489:
487:
474:
473:
471:
470:
462:
460:
454:
453:
451:
450:
442:
440:
434:
433:
431:
430:
422:
420:
414:
413:
411:
410:
402:
400:
394:
393:
391:
390:
382:
380:
374:
373:
371:
370:
362:
360:
354:
353:
351:
350:
342:
340:
329:
328:
326:
325:
317:
315:
309:
308:
306:
305:
298:
290:
289:
288:
285:
284:
280:
279:
276:
267:
266:
263:
257:
256:
253:
247:
246:
239:
238:
236:
235:
222:
220:
214:
213:
209:
208:
206:
205:
172:
170:
164:
163:
141:
139:administration
133:
132:
130:
129:
111:
109:
103:
102:
95:
89:
88:
81:
71:
70:
61:
57:
56:
53:
47:
46:
42:
41:
33:
32:
15:
9:
6:
4:
3:
2:
7031:
7020:
7017:
7015:
7012:
7010:
7009:Phenol ethers
7007:
7005:
7002:
7000:
6997:
6995:
6992:
6990:
6987:
6985:
6982:
6980:
6977:
6975:
6972:
6970:
6969:Cyclic ethers
6967:
6965:
6962:
6961:
6959:
6949:
6939:
6938:
6935:
6922:
6921:
6917:
6915:
6914:
6906:
6904:
6903:
6899:
6896:
6895:
6892:
6882:
6879:
6876:
6875:
6872:
6869:
6867:
6864:
6862:
6859:
6857:
6854:
6852:
6849:
6847:
6844:
6842:
6839:
6837:
6834:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6812:
6809:
6806:
6805:
6802:
6799:
6797:
6794:
6792:
6789:
6787:
6784:
6782:
6779:
6777:
6774:
6772:
6769:
6767:
6764:
6762:
6759:
6756:
6755:
6752:
6749:
6747:
6744:
6742:
6739:
6737:
6734:
6732:
6729:
6727:
6724:
6722:
6719:
6717:
6714:
6712:
6709:
6707:
6704:
6702:
6699:
6697:
6694:
6692:
6689:
6687:
6684:
6682:
6679:
6677:
6674:
6672:
6669:
6667:
6664:
6662:
6659:
6657:
6654:
6652:
6649:
6647:
6644:
6642:
6641:Aceburic acid
6639:
6637:
6634:
6632:
6629:
6627:
6624:
6621:
6620:
6618:
6613:
6604:
6601:
6599:
6595:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6564:
6560:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6535:
6534:
6531:
6528:
6526:
6524:
6520:
6518:
6515:
6513:
6510:
6508:
6505:
6503:
6500:
6498:
6495:
6493:
6490:
6488:
6485:
6483:
6480:
6478:
6475:
6473:
6470:
6468:
6465:
6463:
6460:
6458:
6455:
6453:
6451:
6447:
6445:
6442:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6422:
6420:
6417:
6415:
6412:
6409:
6408:
6405:
6402:
6400:
6397:
6395:
6392:
6390:
6387:
6384:
6383:
6380:
6377:
6375:
6372:
6370:
6367:
6365:
6362:
6360:
6357:
6355:
6352:
6350:
6348:
6344:
6342:
6339:
6337:
6334:
6332:
6331:Ibotenic acid
6329:
6327:
6324:
6322:
6319:
6317:
6314:
6312:
6309:
6307:
6304:
6302:
6299:
6296:
6295:
6293:
6288:
6278:
6272:
6269:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6176:Propybicyphat
6174:
6172:
6169:
6166:
6162:
6158:
6154:
6151:
6149:
6146:
6144:
6141:
6139:
6138:Oenanthotoxin
6136:
6133:
6129:
6125:
6121:
6117:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6078:
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6048:
6047:Iomazenil (I)
6045:
6043:
6040:
6038:
6035:
6033:
6030:
6027:
6026:ciprofloxacin
6023:
6020:
6018:
6015:
6012:
6008:
6007:amentoflavone
6004:
6001:
5998:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5959:
5956:
5954:
5951:
5949:
5946:
5944:
5943:Cyclothiazide
5941:
5939:
5936:
5934:
5931:
5929:
5926:
5924:
5921:
5919:
5916:
5914:
5911:
5909:
5906:
5903:
5899:
5895:
5891:
5888:
5886:
5883:
5881:
5878:
5875:
5871:
5867:
5863:
5860:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5823:
5820:
5818:
5815:
5813:
5810:
5808:
5805:
5803:
5800:
5798:
5795:
5793:
5790:
5787:
5786:
5783:
5780:
5778:
5775:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5732:Famiraprinium
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5712:
5711:
5707:
5703:
5699:
5698:diethyl ether
5695:
5691:
5687:
5683:
5680:
5677:
5673:
5670:
5668:
5665:
5662:
5658:
5655:
5653:
5650:
5647:
5643:
5640:
5638:
5635:
5633:
5630:
5627:
5623:
5620:
5617:
5613:
5610:
5608:
5605:
5602:
5598:
5595:
5593:
5590:
5587:
5583:
5580:
5578:
5575:
5573:
5572:Norfluoxetine
5570:
5567:
5563:
5559:
5555:
5551:
5547:
5543:
5539:
5535:
5532:
5530:
5527:
5525:
5522:
5519:
5515:
5511:
5507:
5504:
5502:
5499:
5497:
5494:
5492:
5489:
5486:
5482:
5479:
5476:
5472:
5469:
5467:
5464:
5462:
5459:
5456:
5452:
5448:
5445:
5442:
5438:
5435:
5433:
5430:
5428:
5425:
5422:
5418:
5415:
5413:
5412:Clomethiazole
5410:
5408:
5407:Chlormezanone
5405:
5403:
5400:
5398:
5397:Carbamazepine
5395:
5392:
5388:
5385:
5382:
5378:
5375:
5372:
5368:
5365:
5362:
5361:phenobarbital
5358:
5355:
5352:
5348:
5345:
5343:
5340:
5337:
5333:
5329:
5326:
5324:
5321:
5319:
5314:
5313:
5310:
5307:
5305:
5302:
5300:
5297:
5294:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5264:Quisqualamine
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5224:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5199:Methylglyoxal
5197:
5194:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5149:Ibotenic acid
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5112:
5110:
5107:
5105:
5102:
5099:
5098:phenobarbital
5095:
5092:
5090:
5087:
5085:
5082:
5079:
5078:
5076:
5071:
5062:
5059:
5057:
5053:
5049:
5046:
5036:
5031:
5029:
5024:
5022:
5017:
5016:
5013:
5001:
4998:
4996:
4993:
4991:
4988:
4987:
4985:
4983:
4979:
4975:
4969:
4966:
4964:
4961:
4959:
4956:
4954:
4953:Dexamethasone
4951:
4949:
4948:Betamethasone
4946:
4945:
4943:
4941:
4937:
4931:
4928:
4926:
4923:
4921:
4918:
4916:
4913:
4911:
4910:Nitrofurazone
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4880:Ciprofloxacin
4878:
4876:
4875:Chlorhexidine
4873:
4871:
4868:
4866:
4863:
4860:
4856:
4853:
4851:
4848:
4846:
4843:
4842:
4840:
4838:
4834:
4829:
4825:
4817:
4812:
4810:
4805:
4803:
4798:
4797:
4794:
4778:
4776:
4773:
4772:
4770:
4767:
4764:
4761:
4759:
4756:
4755:
4751:
4741:
4738:
4737:
4735:
4733:
4729:
4723:
4720:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4700:
4699:
4697:
4695:
4690:
4686:
4683:
4680:
4676:
4666:
4663:
4662:
4660:
4657:
4653:
4650:
4648:
4643:
4639:
4629:
4625:
4622:
4621:
4619:
4616:
4611:
4605:
4602:
4600:
4597:
4596:
4594:
4590:
4580:
4577:
4575:
4574:Pradofloxacin
4572:
4570:
4567:
4565:
4564:Marbofloxacin
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4542:
4541:
4539:
4537:
4533:
4527:
4523:
4522:Trovafloxacin
4520:
4518:
4515:
4513:
4512:Prulifloxacin
4510:
4508:
4505:
4503:
4502:Clinafloxacin
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4469:
4467:
4465:
4461:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4434:Grepafloxacin
4432:
4430:
4427:
4425:
4422:
4421:
4419:
4417:
4413:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4388:
4384:
4381:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4358:Ciprofloxacin
4356:
4355:
4353:
4351:
4347:
4344:
4342:
4338:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4316:Oxolinic acid
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4298:
4296:
4294:
4290:
4287:
4284:
4277:
4272:
4271:topoisomerase
4266:
4262:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4236:Acediasulfone
4234:
4233:
4231:
4227:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4202:
4200:
4196:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4160:Sulfacetamide
4158:
4156:
4153:
4152:
4150:
4146:
4140:
4137:
4135:
4132:
4130:
4129:Sulfamerazine
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4091:
4089:
4087:
4083:
4077:
4074:
4072:
4069:
4067:
4064:
4063:
4061:
4059:
4055:
4049:
4048:Sulfathiourea
4046:
4043:
4039:
4035:
4034:Sulfathiazole
4032:
4028:
4025:
4024:
4023:
4022:Sulfanilamide
4020:
4017:
4013:
4012:Sulfafurazole
4010:
4007:
4006:Sulfasalazine
4003:
4002:Sulfapyridine
4000:
3998:
3997:Sulfadimidine
3995:
3993:
3990:
3988:
3985:
3984:
3982:
3980:
3976:
3973:
3970:
3965:
3961:
3953:
3950:
3948:
3945:
3943:
3942:Pyrimethamine
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3924:
3923:
3920:
3919:
3917:
3915:
3911:
3908:
3899:
3893:
3889:
3884:
3880:
3876:
3872:
3865:
3860:
3858:
3853:
3851:
3846:
3845:
3842:
3831:
3827:
3823:
3819:
3815:
3811:
3804:
3796:
3790:
3782:
3775:
3761:
3757:
3751:
3744:
3740:
3736:
3730:
3716:on 2011-10-01
3712:
3705:
3701:
3695:
3687:
3686:Business Wire
3683:
3677:
3669:
3665:
3659:
3643:
3639:
3635:
3629:
3621:
3617:
3612:
3607:
3603:
3599:
3595:
3591:
3587:
3580:
3572:
3568:
3564:
3558:
3556:
3542:
3532:
3528:
3521:
3515:
3496:
3492:
3485:
3478:
3476:
3467:
3463:
3459:
3455:
3451:
3447:
3440:
3438:
3429:
3425:
3419:
3415:
3414:
3406:
3398:
3394:
3389:
3384:
3380:
3376:
3372:
3368:
3364:
3357:
3349:
3345:
3338:
3324:on 2008-09-16
3320:
3313:
3307:
3292:
3288:
3282:
3274:
3270:
3266:
3262:
3258:
3254:
3247:
3239:
3235:
3231:
3227:
3223:
3219:
3215:
3211:
3204:
3193:
3189:
3182:
3176:
3168:
3164:
3160:
3156:
3152:
3148:
3144:
3140:
3132:
3116:
3112:
3106:
3098:
3094:
3090:
3086:
3079:
3072:
3068:
3062:
3054:
3050:
3046:
3042:
3038:
3034:
3030:
3026:
3019:
3003:
2999:
2992:
2984:
2980:
2975:
2970:
2966:
2962:
2958:
2951:
2943:
2939:
2933:
2914:
2910:
2906:
2899:
2892:
2884:
2880:
2876:
2872:
2868:
2864:
2860:
2856:
2849:
2841:
2837:
2831:
2827:
2826:
2818:
2816:
2814:
2805:
2801:
2796:
2791:
2787:
2783:
2780:(7084): 869.
2779:
2775:
2771:
2764:
2756:
2752:
2748:
2744:
2740:
2736:
2732:
2728:
2721:
2713:
2709:
2704:
2699:
2695:
2691:
2687:
2680:
2672:
2668:
2664:
2660:
2656:
2652:
2648:
2644:
2637:
2629:
2625:
2621:
2617:
2613:
2609:
2602:
2594:
2590:
2586:
2580:
2572:
2568:
2563:
2558:
2554:
2550:
2546:
2539:
2531:
2527:
2526:
2521:
2515:
2507:
2503:
2498:
2493:
2489:
2485:
2481:
2474:
2466:
2462:
2457:
2452:
2448:
2444:
2440:
2433:
2425:
2421:
2416:
2411:
2407:
2403:
2399:
2392:
2384:
2380:
2376:
2372:
2365:
2357:
2353:
2349:
2346:(in French).
2345:
2341:
2334:
2326:
2322:
2318:
2314:
2310:
2306:
2299:
2291:
2287:
2282:
2277:
2273:
2269:
2265:
2258:
2250:
2246:
2242:
2238:
2234:
2230:
2226:
2222:
2215:
2207:
2203:
2198:
2193:
2189:
2185:
2181:
2174:
2166:
2162:
2157:
2152:
2148:
2144:
2140:
2133:
2125:
2121:
2117:
2113:
2109:
2105:
2101:
2097:
2090:
2082:
2078:
2074:
2070:
2066:
2062:
2054:
2046:
2042:
2037:
2032:
2028:
2024:
2020:
2013:
2005:
2001:
1997:
1991:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1948:
1944:
1939:
1934:
1930:
1926:
1922:
1915:
1913:
1904:
1900:
1895:
1890:
1886:
1882:
1878:
1874:
1870:
1863:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1827:
1820:
1812:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1777:
1761:
1757:
1751:
1749:
1747:
1745:
1743:
1741:
1725:
1721:
1715:
1699:
1695:
1691:
1685:
1676:
1671:
1667:
1663:
1657:
1649:
1645:
1643:9783527607495
1639:
1635:
1634:
1626:
1610:
1606:
1605:www.drugs.com
1602:
1596:
1588:
1586:9789241547659
1582:
1578:
1574:
1570:
1566:
1560:
1552:
1550:9780857111562
1546:
1542:
1536:
1534:
1517:
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1507:
1505:
1503:
1501:
1499:
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1474:
1472:
1471:
1466:
1462:
1461:
1456:
1452:
1447:
1443:
1433:
1431:
1415:
1413:
1409:
1404:
1402:
1398:
1394:
1389:
1386:
1384:
1383:ciprofloxacin
1379:
1377:
1372:
1370:
1366:
1362:
1352:
1350:
1346:
1342:
1338:
1337:Gram-negative
1334:
1333:Gram-positive
1330:
1320:
1317:
1315:
1310:
1308:
1304:
1300:
1295:
1293:
1289:
1285:
1280:
1272:
1268:
1264:
1259:
1250:
1248:
1244:
1240:
1236:
1225:
1222:
1217:
1213:
1208:
1199:
1196:
1187:
1185:
1181:
1177:
1176:liver disease
1173:
1163:
1160:
1158:
1155:barbiturate,
1154:
1150:
1146:
1142:
1141:acenocoumarol
1137:
1134:
1131:
1127:
1125:
1121:
1116:
1112:
1110:
1106:
1102:
1100:
1096:
1091:
1089:
1084:
1078:
1076:
1072:
1068:
1064:
1060:
1056:
1050:
1048:
1042:
1038:
1026:
1025:
1021:
1020:
1019:
1014:
1013:
1009:
1007:
1006:
1002:
1000:
999:
995:
993:
992:
988:
986:
985:
981:
979:
978:
974:
972:
971:
967:
964:
960:
959:
955:
954:
953:
948:
947:
943:
940:
936:
935:
931:
928:
924:
923:
919:
918:
917:
914:
906:
904:
900:
896:
892:
891:United States
888:
887:
881:
879:
872:
868:
866:
863:
861:
857:
855:
851:
849:
845:
843:
839:
835:
833:
830:
828:
824:
820:
817:
815:
811:
808:
804:
803:
802:
794:
788:
784:
779:
777:
773:
769:
765:
761:
757:
752:
750:
746:
742:
738:
734:
730:
726:
722:
718:
714:
710:
706:
702:
698:
695:. When taken
694:
690:
686:
676:
669:
660:
655:
654:
651:
644:
635:
634:
631:
624:
620:
618:
617:Melting point
614:
611:
608:
606:
602:
595:
591:
590:
588:
585:
580:
573:
571:
567:
537:
535:
531:
526:
522:
518:
515:
513:
511:ECHA InfoCard
507:
499:
495:
494:DTXSID3041085
491:
490:
488:
479:
475:
468:
464:
463:
461:
459:
455:
448:
444:
443:
441:
439:
435:
428:
424:
423:
421:
419:
415:
408:
404:
403:
401:
399:
395:
388:
384:
383:
381:
379:
375:
368:
364:
363:
361:
359:
355:
348:
344:
343:
341:
334:
330:
323:
319:
318:
316:
314:
310:
302:
297:
296:
293:
286:
281:
277:
275:
268:
264:
262:
258:
254:
252:
248:
244:
240:
234:
224:
223:
221:
219:
215:
210:
202:
197:
192:
187:
182:
177:
174:
173:
171:
169:
165:
161:
157:
153:
149:
145:
142:
140:
134:
127:
122:
113:
112:
110:
108:
104:
100:
96:
94:
90:
86:
82:
80:
76:
72:
67:
62:
58:
54:
52:
48:
45:Clinical data
43:
39:
34:
30:
25:
6918:
6907:
6900:
6877:
6808:Antagonists:
6807:
6757:
6622:
6598:Metabotropic
6569:Pregnanolone
6563:picrotoxinin
6536:
6522:
6449:
6419:(S)-4-ACPBPA
6414:(S)-2-MeGABA
6411:Antagonists:
6410:
6385:
6374:Thiomuscimol
6346:
6297:
6161:picrotoxinin
6124:enzalutamide
6120:bicalutamide
6042:Golexanolone
5938:Cloflubicyne
5788:
5714:Antagonists:
5713:
5626:methaqualone
5601:glutethimide
5577:Petrichloral
5538:β-carbolines
5357:Barbiturates
5315:
5299:Thiomuscimol
5104:Beta-Alanine
5094:Barbiturates
5084:(+)-Catechin
5080:
4968:Prednisolone
4930:Tetracycline
4914:
4732:Lipiarmycins
4579:Sarafloxacin
4569:Orbifloxacin
4554:Enrofloxacin
4544:Danofloxacin
4517:Sitafloxacin
4497:Moxifloxacin
4492:Gemifloxacin
4487:Finafloxacin
4482:Gatifloxacin
4477:Delafloxacin
4472:Besifloxacin
4454:Tosufloxacin
4449:Temafloxacin
4444:Sparfloxacin
4439:Pazufloxacin
4429:Balofloxacin
4424:Levofloxacin
4383:Nadifloxacin
4378:Lomefloxacin
4362:
4198:Combinations
4180:Sulfametrole
4165:Sulfaclozine
4071:Sulfadiazine
3979:Short-acting
3964:Sulfonamides
3952:Trimethoprim
3813:
3809:
3803:
3780:
3774:
3763:. Retrieved
3759:
3750:
3742:
3729:
3718:. Retrieved
3711:the original
3694:
3685:
3676:
3658:
3646:. Retrieved
3637:
3628:
3593:
3589:
3579:
3571:the original
3566:
3531:the original
3526:
3514:
3502:. Retrieved
3495:the original
3490:
3482:Atarashi S.
3449:
3445:
3412:
3405:
3370:
3366:
3356:
3337:
3326:. Retrieved
3319:the original
3306:
3295:. Retrieved
3281:
3256:
3252:
3246:
3213:
3209:
3203:
3192:the original
3175:
3142:
3138:
3131:
3119:. Retrieved
3114:
3105:
3088:
3084:
3078:
3061:
3028:
3024:
3018:
3006:. Retrieved
3002:the original
2991:
2964:
2960:
2950:
2932:
2920:. Retrieved
2913:the original
2904:
2891:
2858:
2854:
2848:
2824:
2777:
2773:
2763:
2730:
2726:
2720:
2693:
2689:
2679:
2646:
2642:
2636:
2611:
2607:
2601:
2593:the original
2579:
2552:
2548:
2538:
2530:the original
2523:
2514:
2487:
2483:
2473:
2446:
2442:
2432:
2405:
2401:
2391:
2374:
2370:
2364:
2347:
2343:
2333:
2308:
2304:
2298:
2271:
2267:
2257:
2224:
2220:
2214:
2190:(4): 49–54.
2187:
2183:
2173:
2146:
2142:
2132:
2099:
2095:
2089:
2064:
2060:
2053:
2026:
2022:
2012:
2004:the original
1990:
1965:
1961:
1955:
1928:
1924:
1876:
1872:
1862:
1829:
1825:
1819:
1786:
1782:
1776:
1764:. Retrieved
1759:
1727:. Retrieved
1723:
1714:
1702:. Retrieved
1693:
1684:
1675:10665/325771
1665:
1656:
1632:
1625:
1613:. Retrieved
1604:
1595:
1568:
1559:
1540:
1520:. Retrieved
1475:
1468:
1458:
1457:, including
1449:
1426:
1408:levofloxacin
1405:
1390:
1387:
1380:
1373:
1358:
1326:
1318:
1313:
1311:
1303:levofloxacin
1296:
1276:
1270:
1266:
1231:
1212:azithromycin
1209:
1205:
1197:
1193:
1169:
1161:
1138:
1135:
1132:
1128:
1117:
1113:
1108:
1104:
1103:
1098:
1092:
1079:
1071:sulfonamides
1051:
1044:
1022:
1017:
1010:
1003:
996:
989:
982:
975:
968:
962:
956:
951:
944:
932:
920:
915:
912:
884:
882:
875:
858:Complicated
832:Epididymitis
800:
797:Medical uses
780:
753:
751:is present.
745:otitis media
684:
683:
672:
300:
271:Elimination
218:Legal status
212:Legal status
107:License data
65:
7004:Otologicals
6881:Compound 14
6711:Lesogaberan
6550:Loreclezole
6487:Loreclezole
6424:(S)-4-ACPCA
6404:Lanthanides
6394:Alphaxolone
6336:Isoguvacine
6246:Terbequinil
6116:apalutamide
6107:Nicardipine
6067:Laudanosine
5874:carbapenems
5866:penicillins
5722:Coriamyrtin
5717:Bicuculline
5706:sevoflurane
5702:paraldehyde
5652:Stiripentol
5529:Niacinamide
5514:cholesterol
5496:Loreclezole
5391:meprobamate
5347:Avermectins
5214:Nefiracetam
5179:Kojic amine
5169:Isomuscimol
5164:Isoguvacine
4982:anesthetics
4920:Polymyxin B
4845:Acetic acid
4765:from market
4740:Fidaxomicin
4712:Rifapentine
4665:Secnidazole
4658:derivatives
4599:Nemonoxacin
4559:Ibafloxacin
4507:Garenoxacin
4396:Norfloxacin
4246:Solasulfone
4185:Sulfanitran
4139:Sulfamazone
4099:Sulfadoxine
4086:Long-acting
4076:Sulfamoxole
3947:Tetroxoprim
3927:Brodimoprim
3904:DNA and RNA
3892:Antifolates
3756:"Ofloxacin"
3638:CenterWatch
3342:Drugs.com.
3091:(1): 8–15.
2096:Drug Safety
1615:28 December
1577:10665/44053
1512:"Ofloxacin"
1465:enterococci
1365:norfloxacin
1263:enantiomers
1216:ceftriaxone
1145:anisindione
1109:Clostridium
1095:QT interval
1067:clindamycin
1063:penicillins
927:methicillin
865:Prostatitis
717:prostatitis
577: g·mol
517:100.205.209
283:Identifiers
93:MedlinePlus
60:Other names
51:Trade names
6958:Categories
6736:SKF-97,541
6646:Arbaclofen
6555:Picrotoxin
6545:Bilobalide
6221:Suritozole
6211:Sarmazenil
6196:Ro 19-4603
6191:Ro 15-4513
6186:Radequinil
6153:Picrotoxin
6132:nilutamide
6102:Naltrexone
6037:Furosemide
6017:Flumazenil
6011:oroxylin A
6003:Flavonoids
5983:Etbicyphat
5913:Bilobalide
5880:Basmisanil
5767:Sinomenine
5762:Securinine
5757:Pitrazepin
5742:Hydrastine
5694:chloroform
5667:Topiramate
5607:Propanidid
5471:Imidazoles
5466:Flupirtine
5461:Fluoxetine
5455:hispidulin
5447:Flavonoids
5402:Chloralose
5387:Carbamates
5351:ivermectin
5289:Terpenoids
5234:PF-6372865
5089:Bamaluzole
5056:Ionotropic
5048:modulators
4978:Analgesics
4900:Miconazole
4890:Gentamicin
4885:Clioquinol
4865:Boric acid
4702:Rifampicin
4689:Rifamycins
4647:inhibitors
4628:Novobiocin
4604:Ozenoxacin
4549:Difloxacin
4536:Veterinary
4406:Rufloxacin
4401:Pefloxacin
4373:Fleroxacin
4306:Flumequine
4276:DNA gyrase
4265:Quinolones
4124:Sulfaperin
3937:Ormetoprim
3906:synthesis)
3765:2022-11-16
3720:2009-05-15
3648:August 25,
3541:US 4382892
3328:2009-10-25
3297:2009-04-20
1729:14 January
1704:14 January
1522:8 December
1485:References
1451:Resistance
1440:See also:
1430:ornidazole
1345:DNA gyrase
1307:enantiomer
1237:toxicity,
1075:vancomycin
1059:macrolides
1035:See also:
939:penicillin
827:cervicitis
823:urethritis
709:cellulitis
582:3D model (
570:Molar mass
447:CHEBI:7731
407:A4P49JAZ9H
378:ChemSpider
322:82419-36-1
313:CAS Number
292:IUPAC name
6871:SKF-97541
6866:SCH-50911
6856:Phaclofen
6841:CGP-64213
6836:CGP-55845
6831:CGP-54626
6826:CGP-52432
6821:CGP-46381
6816:CGP-35348
6786:CGP-13501
6761:ADX-71441
6746:Tolgabide
6726:Progabide
6721:Picamilon
6706:Isovaline
6623:Agonists:
6525:-3-ACPBPA
6502:SKF-97541
6452:-3-ACPBPA
6379:Tolgabide
6359:Progabide
6354:Picamilon
6298:Agonists:
6206:RO4938581
6201:RO4882224
6128:flutamide
6062:L-655,708
6032:Flurothyl
5933:Cicutoxin
5918:Bupropion
5885:Bemegride
5862:β-Lactams
5852:Amiloride
5682:Volatiles
5616:etazolate
5592:Phenytoin
5550:zopiclone
5542:abecarnil
5501:Monastrol
5491:Lanthanum
5475:etomidate
5437:Fenamates
5432:Etifoxine
5427:Etazepine
5304:Tolgabide
5254:Progabide
5244:Picamilon
5229:Org 20599
5204:Monastrol
5184:L-838,417
5081:Agonists:
5000:Phenazone
4990:Lidocaine
4925:Rifamycin
4915:Ofloxacin
4837:Infection
4775:Phase III
4763:Withdrawn
4722:Rifalazil
4717:Rifaximin
4707:Rifabutin
4681:synthesis
4642:Anaerobic
4613:Related (
4363:Ofloxacin
4331:Rosoxacin
4301:Cinoxacin
4251:Sulfoxone
4104:Sulfalene
4027:Prontosil
3789:cite book
3527:memorANDA
3504:25 August
3121:6 January
3071:0277-0008
2922:31 August
1811:255433752
1803:0891-4168
1766:6 January
1455:pathogens
1243:articular
1190:Pregnancy
1180:pregnancy
1157:quinidine
1149:dicumarol
903:Australia
871:gonorrhea
814:pneumonia
768:pregnancy
766:. Use in
764:psychosis
705:pneumonia
685:Ofloxacin
605:Chirality
278:8–9 hours
273:half-life
255:85% – 95%
160:ear drops
156:eye drops
137:Routes of
126:Ofloxacin
85:Monograph
79:Drugs.com
21:Ofloxacin
6948:Medicine
6897:See also
6861:Saclofen
6796:rac-BHFF
6791:GS-39783
6781:CGP-7930
6741:SL 75102
6716:Phenibut
6671:Gabamide
6656:Baclofen
6559:picrotin
6512:SR-95813
6507:SR-95318
6429:2-MeTACA
6341:Muscimol
6271:ZK-93426
6241:TCS-1105
6226:TB-21007
6157:picrotin
6097:Naloxone
6082:Morphine
6077:MaxiPost
5997:fipronil
5993:Fiproles
5963:(+)-DMBB
5958:Dieldrin
5857:Anisatin
5772:SR-42641
5672:Valerian
5646:baicalin
5642:Skullcap
5586:propofol
5566:zaleplon
5558:zolpidem
5451:apigenin
5371:diazepam
5328:Alcohols
5269:SL-75102
5259:Propofol
5239:Phenibut
5209:Muscimol
5193:honokiol
5159:iso-THIP
5154:iso-THAZ
5129:Gabamide
5045:receptor
4905:Neomycin
4368:Enoxacin
4155:Mafenide
3932:Iclaprim
3830:15745724
3739:Archived
3702:(2003).
3668:Archived
3642:Archived
3466:18611493
3428:Archived
3348:Archived
3291:Archived
3273:10424513
3230:14511503
3167:26457648
3159:17901792
3115:DailyMed
3097:12700435
3053:26688176
3045:16105873
3008:July 22,
2983:12912715
2942:Archived
2883:34091286
2875:17559736
2840:Archived
2755:26411679
2747:17911203
2712:16876974
2671:36759747
2663:24259701
2628:15661570
2571:22921930
2506:24324224
2465:23620467
2424:11909831
2383:23570031
2356:10970974
2325:16139623
2290:15942881
2241:17334751
2206:20725547
2165:18694344
2124:19026852
2116:19419232
2081:17165634
2045:22489673
1982:11172695
1947:15942881
1846:15102567
1760:DailyMed
1724:ClinCalc
1698:Archived
1694:ClinCalc
1664:(2019).
1648:Archived
1609:Archived
1516:Archived
1314:In vitro
1261:The two
1228:Overdose
1202:Children
1184:epilepsy
1111:strain.
878:syphilis
854:cystitis
760:seizures
749:ear drum
741:ear drop
733:eye drop
697:by mouth
675:(verify)
358:DrugBank
168:ATC code
144:By mouth
121:DailyMed
6766:BHF-177
6751:Tolibut
6661:BL-1020
6574:ROD-188
6439:4-ACPAM
6434:3-APMPA
6301:BL-1020
6261:U-93631
6256:Thujone
6181:PWZ-029
6155:(i.e.,
6114:(e.g.,
6092:MRK-016
6072:Lindane
6024:(e.g.,
6005:(e.g.,
5995:(e.g.,
5864:(e.g.,
5842:β-EMGBL
5752:PHP-501
5688:(e.g.,
5659:(e.g.,
5637:ROD-188
5624:(e.g.,
5614:(e.g.,
5599:(e.g.,
5584:(e.g.,
5582:Phenols
5564:(e.g.,
5556:(e.g.,
5548:(e.g.,
5540:(e.g.,
5536:(e.g.,
5508:(e.g.,
5473:(e.g.,
5449:(e.g.,
5439:(e.g.,
5419:(e.g.,
5389:(e.g.,
5377:Bromide
5369:(e.g.,
5359:(e.g.,
5349:(e.g.,
5330:(e.g.,
5323:α-EMTBL
5293:borneol
5291:(e.g.,
5274:Taurine
5221:(e.g.,
5191:(e.g.,
5189:Lignans
5109:BL-1020
5096:(e.g.,
4995:Cocaine
4274:and/or
4241:Dapsone
3620:8363378
3491:Daiichi
3397:9293187
3238:7676548
3186:. U.S.
2907:. U.S.
2804:9093098
2795:2126221
2587:. U.S.
2249:3330687
2197:2921747
1998:. U.S.
1903:6960805
1854:1706114
1355:History
1299:racemic
1288:biliary
1247:hepatic
1124:seizure
838:urethra
739:and an
575:361.373
534:Formula
467:ChEMBL4
367:DB01165
333:PubChem
198: (
196:S02AA16
188: (
186:S01AE01
184:)
178: (
176:J01MA01
152:topical
123::
99:a691005
6934:Portal
6801:KK-92A
6631:3-APPA
6399:ATHDOC
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