Knowledge

Medicinal uses of fungi

Source πŸ“

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Overy, David P.; Larsen, Thomas O.; Dalsgaard, Petur W.; Frydenvang, Karla; Phipps, Richard; Munro, Murray H.G.; Christophersen, Carsten (November 2005). "Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance
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Kim H, Baker JB, Park Y, Park HB, DeArmond PD, Kim SH, et al. (August 2010). "Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B".
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in 1928. Since that time, many potential antibiotics were discovered and the potential for various fungi to synthesize biologically active molecules useful in various clinical therapies has been under research.
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Zhang T, Ye J, Xue C, Wang Y, Liao W, Mao L, et al. (October 2018). "Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes".
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Lo HC, Wasser SP (2011). "Medicinal mushrooms for glycemic control in diabetes mellitus: history, current status, future perspectives, and unsolved problems (review)".
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Numerous fungi have well-documented psychotropic effects, some of them severe and associated with acute and life-threatening side-effects. Among these is
125:, known in Chinese as lΓ­ng zhΔ« ("spirit plant"), and in Japanese as mannentake ("10,000-year mushroom"), has been well studied. Another species of genus 2042: 505: 2049: 543:
Lentinus edodes, Ganoderma lucidum, Ganoderma colossus, Hypsizygus marmoreus, Cordyceps militaris, Grifola frondosa, Scleroderma citrinum,
1436:"Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans" 1091:
Shrivastava A, Khan AA, Shrivastav A, Jain SK, Singhal PK (2012). "Kinetic studies of L-asparaginase from Penicillium digitatum".
894: 918:"Production of antibiotics by Collybia nivalis, Omphalotus olearis, a Favolaschia and a Pterula species on natural substrates" 1410: 1377: 1349: 1973: 440: 17: 2057: 2238: 2203: 1700: 89:, the ability to identify beneficial properties and then extract the active ingredient started with the discovery of 2106: 1037: 191: 2460: 178:, was used to create dozens of semi-synthetic, candidate anticancer compounds. 11,11'-Dideoxyverticillin A, 1886:
Kamweru PK, Tindibale EL (2016). "Vitamin D and Vitamin D from Ultraviolet-Irradiated Mushrooms (Review)".
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Pradeep, Prabin; Manju, Vidya; Ahsan, Mohammad Feraz (2019). "Antiviral Potency of Mushroom Constituents".
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Many mushrooms contain potential antiviral compounds remaining under preliminary research, such as:
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There is no good evidence that any type of mushroom or mushroom extract can prevent or cure cancer.
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Tobert JA (July 2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors".
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drugs have subsequently been extracted from or synthesised starting from ergot; these include
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Cardwell, Glenn; Bornman, Janet; James, Anthony; Black, Lucinda (13 October 2018).
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Schade R, Andersohn F, Suissa S, Haverkamp W, Garbe E (January 2007).
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Jahromi MF, Liang JB, Ho YW, Mohamad R, Goh YM, Shokryazdan P (2012).
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Some antifungals are derived or extracted from other fungal species.
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Keegan RJ, Lu Z, Bogusz JM, Williams JE, Holick MF (January 2013).
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Zheng W, Miao K, Liu Y, Zhao Y, Zhang M, Pan S, Dai Y (July 2010).
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Broadbent, Douglas (July 1966). "Antibiotics Produced by Fungi".
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was used in Russia as early as the 16th century; it featured in
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The history of bread-making records deadly ergotism caused by
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are under research for their potential antibiotic activity.
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The European Monitoring Centre for Drugs and Drug Addiction
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Nagaraj G, Uma MV, Shivayogi MS, Balaram H (January 2001).
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are an important class of cholesterol-lowering drugs; the
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Ling Zhi-8, an immunomodulatory protein isolated from
1286: 254: 605:. Subglutinols are immunosuppressants isolated from 658:is a fungal isolate that may affect hyperglycemia. 475:, a cholesterol biosynthesis inhibitor, is made by 1344:. Lippincott Williams & Wilkins. p. 631. 1392: 1364: 1136:"The use of lentinan for treating gastric cancer" 915: 463:, can synthesize lovastatin, mevastatin, and the 41:or can be induced to produce metabolites through 2422: 1885: 1576: 1185: 1183: 1181: 1179: 964: 156: 224:is a potential source of the leukemia medicine 85:Although fungi products have long been used in 1716: 1714: 1484: 1133: 2100: 1341:Disinfection, Sterilization, and Preservation 1176: 27:Fungi that can be used to develop medications 1888:International Journal of Medicinal Mushrooms 1727:American Journal of Pharmaceutical Education 1664:International Journal of Medicinal Mushrooms 1570: 1280: 1093:Preparative Biochemistry & Biotechnology 585:. Thermophilic fungi were the source of the 1711: 1127: 1084: 1048: 958: 699:, a parasite of cereal crops. Psychoactive 550:Trametes versicolor, Fomitopsis officinalis 2107: 2093: 1293:Journal of Biomedicine & Biotechnology 1239: 1237: 909: 214:, are anticancer/cytotoxic metabolites of 1974:"Sanofi launches malaria drug production" 1948: 1938: 1862: 1813: 1746: 1695: 1693: 1638: 1553: 1527: 1461: 1451: 1370:Fungal Infection Diagnosis and Management 1314: 1304: 1189: 1159: 1140:Anti-Cancer Agents in Medicinal Chemistry 1015:"Medicinal mushrooms in cancer treatment" 982: 933: 895:"Discovery and Development of Penicillin" 832:is used industrially to produce vitamins 366:are derivatives of the fungal metabolite 2114: 1661: 1433: 750: 441:first generation of statins were derived 413: 340: 1701:"Hallucinogenic mushrooms drug profile" 1234: 1035: 661: 14: 2423: 1971: 1720: 1690: 1243: 1134:Ina K, Kataoka T, Ando T (June 2013). 971:Applied Microbiology and Biotechnology 2088: 1619:Antimicrobial Agents and Chemotherapy 1337: 555: 2391: 916:Engler M, Anke T, Sterner O (1998). 870:is used industrially to produce the 796:is used industrially to produce the 630:are made by fungi, and remain under 2403: 1802:The New England Journal of Medicine 1007: 410:Cholesterol biosynthesis inhibitors 24: 1900:10.1615/IntJMedMushrooms.v18.i3.30 1721:Schiff, Paul L. (September 2006). 1036:Trafton, Anne (27 February 2013). 887: 860:is used to produce the amino acid 846:is used to produce the amino acid 274:. Subsequent discoveries included 255:Antibacterial agents (antibiotics) 25: 2472: 1988: 1769: 2402: 2390: 2379: 2378: 1772:"Medical Definition of Ergotism" 1056:and pathological implications". 922:Zeitschrift fΓΌr Naturforschung C 525:, are all extracted from fungi. 137:, remains under basic research. 1965: 1914: 1879: 1830: 1789: 1763: 1655: 1606: 1521: 1478: 1427: 1386: 1358: 1338:Block, Seymour Stanton (2001). 1331: 597:synthesizes immunosuppressants 192:farnesyl transferase inhibitors 1972:Peplow, Mark (16 April 2013). 1676:10.1615/intjmedmushr.v13.i5.10 1246:Nature Reviews. Drug Discovery 1029: 484: 13: 1: 1631:10.1128/aac.45.1.145-149.2001 1546:10.1080/21501203.2018.1536680 1499:10.1016/j.carbpol.2018.05.069 880: 746: 536: 231:Some countries have approved 157:Research and drug development 1434:Friedman M (November 2016). 1403:10.1007/978-981-13-6382-5_10 1368:; Warnock, David W. (2003). 1105:10.1080/10826068.2012.672943 648:alpha-glucosidase inhibitors 642:Many fungal isolates act as 493:is derived from a number of 7: 2043:Trametes versicolor and PSK 2008:Trametes versicolor and PSK 1580:Chemistry: An Asian Journal 1152:10.2174/1871520611313050002 818:yeasts are used to produce 637: 10: 2477: 2070:National Cancer Institute 1528:Girometta C (March 2019). 771:which can be converted to 614: 575:Eupenicillium brefeldianum 80: 2374: 2366:List of mycology journals 2343: 2312: 2272: 2192: 2185: 2139: 2126: 1994:Memorial Sloan-Kettering 1723:"Ergot and Its Alkaloids" 1070:10.1017/s0953756205003734 984:10.1007/s00253-010-2682-4 785: 161: 2041:American Cancer Society 810:and hepatitis B surface 652:alpha amylase inhibitors 583:Penicillium stoloniferum 478:Saccharomyces cerevisiae 654:in laboratory studies. 428:, can synthesize three 264:beta-lactam antibiotics 174:, an isolate of marine 1592:10.1002/asia.201000147 1366:Richardson, Malcolm D. 935:10.1515/znc-1998-5-604 767:Fungi are a source of 764: 566:Tolypocladium inflatum 529:is a derivative of an 433: 351: 245:polysaccharide peptide 117:compounds from fungi. 65:synthesis inhibitors, 2356:List of fungal orders 1996:Agaricus subrufescens 1843:Dermato-Endocrinology 1487:Carbohydrate Polymers 754: 608:Fusarium subglutinans 473:Nicotinamide riboside 417: 344: 249:immunologic adjuvants 145:Alexandr Solzhenitsyn 2461:Antiparasitic agents 2351:Glossary of mycology 1815:10.1056/NEJMoa062222 1453:10.3390/foods5040080 1397:. pp. 275–297. 1192:The Botanical Review 1058:Mycological Research 1017:. Cancer Research UK 805:recombinant proteins 662:Psychotropic effects 546:Flammulina velutipes 194:that can be made by 172:Dideoxyverticillin A 87:traditional medicine 2361:List of mycologists 2020:Pleurotus ostreatus 1395:Medicinal Mushrooms 1306:10.1155/2012/196264 1204:1966BotRv..32..219B 626:, zervamicins, and 450:Aspergillus terreus 262:led the way to the 18:Medicinal mushrooms 2451:Immunosuppressants 2133:Outline of lichens 2063:2009-06-14 at the 2052:2010-03-31 at the 1940:10.3390/nu10101498 1855:10.4161/derm.23321 1770:Shiel, William C. 1212:10.1007/BF02858660 765: 696:Claviceps purpurea 563:was discovered in 556:Immunosuppressants 460:Monascus purpureus 434: 425:Monascus purpureus 352: 200:3-O-Methylfunicone 188:barceloneic acid B 184:barceloneic acid A 71:immunosuppressants 47:prescription drugs 2418: 2417: 2308: 2307: 2204:teleomorph/sexual 2016:Inonotus obliquus 2004:Ganoderma lucidum 2000:Phellinus linteus 1412:978-981-13-6381-8 1379:978-1-4051-1578-0 1351:978-0-683-30740-5 1064:(11): 1243–1249. 778:upon exposure to 709:dihydroergotamine 676:"magic mushrooms" 579:mycophenolic acid 506:Glarea lozoyensis 376:austrocortilutein 348:Ganoderma lucidum 338:and many others. 314:, helvolic acid, 260:Alexander Fleming 140:Inonotus obliquus 122:Ganoderma lucidum 95:Alexander Fleming 55:anti-cancer drugs 16:(Redirected from 2468: 2406: 2405: 2394: 2393: 2382: 2381: 2239:anamorph/asexual 2190: 2189: 2129:Outline of fungi 2109: 2102: 2095: 2086: 2085: 2047:Grifola frondosa 2012:Grifola frondosa 1982: 1981: 1969: 1963: 1962: 1952: 1942: 1918: 1912: 1911: 1883: 1877: 1876: 1866: 1834: 1828: 1827: 1817: 1793: 1787: 1786: 1784: 1782: 1767: 1761: 1760: 1750: 1739:10.5688/aj700598 1718: 1709: 1708: 1697: 1688: 1687: 1659: 1653: 1652: 1642: 1610: 1604: 1603: 1574: 1568: 1567: 1557: 1525: 1519: 1518: 1482: 1476: 1475: 1465: 1455: 1431: 1425: 1424: 1390: 1384: 1383: 1362: 1356: 1355: 1335: 1329: 1328: 1318: 1308: 1284: 1278: 1277: 1241: 1232: 1231: 1187: 1174: 1173: 1163: 1131: 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963: 959: 928:(5–6): 318–24. 914: 910: 900: 898: 893: 892: 888: 883: 824:insulin analogs 788: 776: 762: 749: 664: 640: 617: 558: 539: 487: 412: 257: 169: 164: 159: 100:Pharmacological 83: 31:Medicinal fungi 28: 23: 22: 15: 12: 11: 5: 2474: 2464: 2463: 2458: 2453: 2448: 2443: 2438: 2433: 2416: 2415: 2413: 2412: 2400: 2388: 2375: 2372: 2371: 2369: 2368: 2363: 2358: 2353: 2347: 2345: 2341: 2340: 2338: 2337: 2332: 2327: 2322: 2316: 2314: 2310: 2309: 2306: 2305: 2303: 2302: 2297: 2292: 2287: 2282: 2276: 2274: 2270: 2269: 2267: 2266: 2261: 2256: 2251: 2246: 2234: 2233: 2220: 2211: 2199: 2197: 2187: 2183: 2182: 2180: 2179: 2177:Mycotoxicology 2174: 2169: 2164: 2159: 2154: 2149: 2143: 2141: 2137: 2136: 2127: 2124: 2123: 2112: 2111: 2104: 2097: 2089: 2083: 2082: 2068: 2039: 1990: 1989:External links 1987: 1984: 1983: 1964: 1913: 1878: 1829: 1788: 1762: 1710: 1689: 1654: 1605: 1586:(8): 1902–10. 1569: 1520: 1477: 1426: 1411: 1385: 1378: 1357: 1350: 1330: 1279: 1233: 1198:(3): 219–242. 1175: 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Index

Medicinal mushrooms
fungi
metabolites
biotechnology
prescription drugs
antibiotics
anti-cancer drugs
cholesterol
ergosterol
psychotropic
immunosuppressants
fungicides
traditional medicine
penicillin
Alexander Fleming
Pharmacological
research
antifungal
antiviral
antiprotozoan
Ganoderma lucidum
Ganoderma
G. applanatum
Inonotus obliquus
Alexandr Solzhenitsyn
Cancer Ward
Dideoxyverticillin A
andrastin A
barceloneic acid A
barceloneic acid B

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