487:
39:
518:. However, normal ranges for mast cell counts in the gastrointestinal tract mucosa are not well established in the literature, and depend upon the exact location (e.g. right versus left colon), gender, and patient populations (such as asymptomatic patients versus patients with chronic diarrhea of unknown etiology). Quantitative mast cell stains may yield little diagnostic information, and further research studies are warranted to determine whether "mastocytic enterocolitis" truly represents a distinct entity.
126:
137:, the substances that are released can cause a number of symptoms that can vary over time and can range in intensity from mild to severe. Because mast cells play a role in allergic reactions, the symptoms of mastocytosis often are similar to the symptoms of an allergic reaction. They may include, but are not limited to
369:
In case of suspicion of systemic disease the level of serum tryptase in the blood can be of help. If the base level of s-tryptase is elevated, this implies that the mastocytosis can be systemic. In cases of suspicion of SM help can also be drawn from analysis of mutation in KIT(D816V) in peripheral
759:
Some of the most important research advances for this rare disorder include improved diagnosis of mast cell disease and identification of growth factors and genetic mechanisms responsible for increased mast cell production. Researchers are currently evaluating approaches to improve ways to treat
876:
Hermine, Olivier; Lortholary, Olivier; Leventhal, Phillip S.; Catteau, Adeline; Soppelsa, Frédérique; Baude, Cedric; Cohen-Akenine, Annick; Palmérini, Fabienne; Hanssens, Katia; Yang, Ying; Sobol, Hagay; Fraytag, Sylvie; Ghez, David; Suarez, Felipe; Barete, Stéphane; Casassus, Philippe; Sans,
462:
Generalized eruption of cutaneous mastocytosis (adult type) is the most common pattern of mastocytosis presenting to the dermatologist, with the most common lesions being macules, papules, or nodules that are disseminated over most of the body but especially on the upper arms, legs, and
501:
Systemic mastocytosis involves the bone marrow in the majority of cases and in some cases other internal organs, usually in addition to involving the skin. Mast cells collect in various tissues and can affect organs where mast cells do not normally inhabit such as the
1344:
Noack, F.; Escribano, L.; Sotlar, K.; Nunez, R.; Schuetze, K.; Valent, P.; Horny, H.-P. (July 2009). "Evolution of
Urticaria Pigmentosa into Indolent Systemic Mastocytosis: Abnormal Immunophenotype of Mast Cells without Evidence of c-kit Mutation ASP-816-VAL".
1702:
Broesby-Olsen, Sigurd; Farkas, Dóra Körmendiné; Vestergaard, Hanne; Hermann, Anne
Pernille; Møller, Michael Boe; Mortz, Charlotte Gotthard; Kristensen, Thomas Kielsgaard; Bindslev-Jensen, Carsten; Sørensen, Henrik Toft; Frederiksen, Henrik (November 2016).
1450:
Sethi, Aisha; Jain, Dhanpat; Roland, Bani
Chander; Kinzel, Jason; Gibson, Joanna; Schrader, Ronald; Hanson, Joshua Anspach (2015-02-01). "Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use".
763:
Scientists also are focusing on identifying disease-associated mutations (changes in genes). NIH scientists have identified some mutations, which may help researchers understand the causes of mastocytosis, improve diagnosis, and develop better treatments.
939:
Moura, Daniela Silva; Sultan, Serge; Georgin-Lavialle, Sophie; Pillet, Nathalie; Montestruc, François; Gineste, Paul; Barete, Stéphane; Damaj, Gandhi; Moussy, Alain; Lortholary, Olivier; Hermine, Olivier; Hashimoto, Kenji (21 October 2011).
728:
Patients with indolent systemic mastocytosis have a normal life expectancy. The prognosis for patients with advanced systemic mastocytosis differs depending on type of disease with MCL being the most serious form with short survival.
741:"; orphan diseases affect 200,000 or fewer people in the United States. Mastocytosis, however, often may be misdiagnosed, as it typically occurs secondary to another condition, and thus may occur more frequently than assumed.
2641:
3751:
3732:
3717:
3371:
418:
Monoclonal mast cell activation, defined by the World Health
Organization definitions 2010, also has increased mast cells but insufficient to be systemic mastocytosis (in World Health Organization Definitions)
459:(TMEP) is a much rarer form of cutaneous mastocytosis that affects adults. MPCM and TMEP can be a part of indolent systemic mastocytosis. This should be considered if patients develop any systemic symptoms
3446:
2634:
269:
There are few qualitative studies about the effects of mastocytosis on daily life. However, a Danish study from 2018 describes the multidimensional impact of the disease on everyday life.
1206:
Arber, Daniel A.; Orazi, Attilio; Hasserjian, Robert; Thiele, JĂĽrgen; Borowitz, Michael J.; Le Beau, Michelle M.; Bloomfield, Clara D.; Cazzola, Mario; Vardiman, James W. (19 May 2016).
633:
are an important and often overlooked tool in the treatment of mastocytosis. Depression and other neurological symptoms have been noted in mastocytosis. Some antidepressants, such as
288:, the linings of the stomach and intestine, and other sites. They play an important role in the immune defence against bacteria and parasites. By releasing chemical "alarms" such as
2627:
2506:
601:
help reduce production of gastric acid, which is often increased in patients with mastocytosis. Excess gastric acid can harm the stomach, esophagus, and small intestine.
1561:
Rogers, M P; Bloomingdale, K; Murawski, B J; Soter, N A; Reich, P; Austen, K F (July 1986). "Mixed organic brain syndrome as a manifestation of systemic mastocytosis".
649:
In cases of advanced systemic mastocytosis or rare cases with indolent systemic mastocytosis with very troublesome symptoms, cytoreductive therapy can be indicated.
3594:
1705:"Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population-based study"
3462:
2866:
3770:
2895:
2861:
749:
1986:
1753:
350:
receptor (mutation KIT(D816V)), leading to constitutive signalling through the receptor is found in >90% of patients with systemic mastocytosis.
2802:
2427:
2137:
3302:
2797:
2090:
1991:
778:
was first described in 1869. The first report of a primary mast cell disorder is attributed to Unna, who in 1887 reported that skin lesions of
362:(cutaneous mastocytosis, see above) can often be done by seeing the characteristic lesions that are dark brown and fixed. A small skin sample (
607:
constricts blood vessels and opens airways to maintain adequate circulation and ventilation when excessive mast cell degranulation has caused
3604:
3298:
1915:
3110:
2890:
2885:
2875:
2286:
1996:
3629:
3366:
2914:
455:
3249:
3589:
3184:
2909:
2841:
3887:
3838:
3654:
3244:
3239:
2880:
2846:
2407:
478:
Cutaneous mastocytosis in children usually presents in the first year after birth and in most cases vanishes during adolescence.
767:
In Europe the
European Competence Network on Mastocytosis (ECNM) coordinates studies, registries and education on mastocytosis.
2856:
2715:
2063:
1051:
486:
303:, mast cells may play a part in wound healing. For example, the typical itching felt around a healing scab may be caused by
3376:
2961:
2572:
705:
319:
or no mast cells has been found, which indicates to some scientists we may not be able to survive with too few mast cells.
3778:
2851:
2619:
2422:
514:, and organs which have normal populations but where numbers are increased. In the bowel, it may manifest as mastocytic
3669:
3614:
1309:
Ellis DL (1996). "Treatment of telangiectasia macularis eruptiva perstans with the 585-nm flashlamp-pumped dye laser".
737:
The true incidence and prevalence of mastocytosis is unknown, but mastocytosis generally has been considered to be an "
626:
Drugs to prevent/treat osteoporosis include
Calcium-Vitamine D, bisphosphonates and in rare cases inhibitors of RANK-L
424:– has normal number of mast cells, but all the symptoms and in some cases the genetic markers of systemic mastocytosis
3141:
2971:
2904:
1396:
663:(CdA). Chemotherapy which is given as subcutaneous injections. Side effects include immunodeficiency and infections.
373:
To set the diagnosis of systemic mastocytosis, certain criteria must be met. Either one major + one minor criterion
3892:
3254:
2147:
1908:
3158:
851:
708:
has been used in rare cases with aggressive systemic mastocytosis in patients deemed to be fit for the procedure.
3679:
3659:
3609:
3579:
3456:
3229:
2934:
2807:
2792:
2412:
2323:
2152:
2748:
90:
affecting both children and adults caused by the accumulation of functionally defective mast cells (also called
3293:
3204:
2981:
2496:
877:
Beatrice; Arock, Michel; Kinet, Jean Pierre; Dubreuil, Patrice; Moussy, Alain; Soyer, H. Peter (28 May 2008).
3619:
3572:
3199:
3122:
2836:
2782:
2264:
2125:
2023:
753:
470:
may be thickened and infiltrated with mast cells to produce a peculiar orange color, giving rise to the term
421:
1156:"Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future"
3027:
2719:
2604:
2539:
2075:
2001:
1208:"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia"
595:
is available in Canada and Europe and more recently in the U.S. It is also available as eyedrops (Zaditor).
3865:
1754:
To quell unpredictable allergic reactions, an experimental drug takes aim at a genetic cause, not symptoms
3644:
3361:
3021:
2589:
2370:
2306:
2254:
2242:
2013:
1981:
1901:
449:
The most common cutaneous mastocytosis is maculopapular cutaneous mastocytosis, previously named papular
3234:
3105:
3012:
2501:
2268:
666:
1409:
Ramsay, David B.; Stephen, Sindu; Borum, Marie; Voltaggio, Lysandra; Doman, David B. (December 2010).
782:
contained numerous mast cells. Systemic mastocytosis was first reported by French scientists in 1936.
3438:
3004:
2986:
2729:
2316:
2207:
1494:
641:, are themselves potent antihistamines and can help relieve physical as well as cognitive symptoms.
623:
can be used topically, inhaled, or systemically to reduce inflammation associated with mastocytosis.
3789:
3279:
3267:
3225:
3211:
3189:
3179:
3175:
3083:
3078:
3073:
3069:
3061:
3032:
2392:
2358:
2058:
1928:
555:
There is no cure for mastocytosis, but there are a number of medicines to help treat the symptoms:
155:
675:. TKI acting on many different tyrosine kinases, approved by FDA and EMA for advanced mastocytosis
346:
appears to be important for the proliferation of mast cells. Mutations of the gene coding for the
3557:
2976:
2939:
2787:
2085:
1050:
Jensen, Britt; Broesby-Olsen, Sigurd; Bindslev-Jensen, Carsten; Nielsen, Dorthe S. (April 2019).
942:"Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy"
335:
3897:
3854:
3674:
3639:
3562:
3356:
3344:
3194:
3163:
3037:
2990:
2966:
2562:
2348:
2232:
2197:
2115:
2048:
1971:
1609:"Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management"
752:
scientists have been studying and treating patients with mastocytosis for several years at the
3726:
3539:
3450:
2826:
2675:
2599:
598:
323:
249:
657:. Given as subcutaneous injections. Side effects include fatigue and influenza-like symptoms
3529:
3431:
2949:
2521:
2511:
2417:
1893:
953:
890:
584:
490:
467:
307:
released by mast cells. Researchers also think mast cells may have a role in the growth of
245:
146:
2649:
8:
3755:
3337:
3216:
2766:
2724:
2707:
2697:
2680:
2650:
591:
is the only medicine specifically approved by the FDA for the treatment of mastocytosis.
199:
63:
38:
1865:
Gruchalla, Rebecca S. (June 1995). "Mastocytosis: Developments During the Past Decade".
1154:
Valent P, Akin C, Hartmann K, Nilsson G, Reiter A, Hermine O, et al. (March 2017).
957:
894:
3760:
3599:
3115:
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1768:
1734:
1679:
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1586:
1538:
1513:
1427:
1410:
1370:
1296:
1273:
1248:
1180:
1155:
1136:
1079:
1027:
1000:
976:
941:
913:
878:
617:
and other beta-2 agonists open airways that can constrict in the presence of histamine.
537:
210:
3843:
3764:
699:
in trials; currently being tested but showing promise in reduction of tryptase levels.
3800:
3624:
3584:
3506:
3381:
3325:
3259:
2924:
2516:
2471:
2380:
1882:
1878:
1825:
1798:
1726:
1684:
1630:
1578:
1574:
1543:
1476:
1468:
1432:
1392:
1362:
1326:
1322:
1278:
1229:
1185:
1128:
1115:
1098:
1071:
1032:
981:
918:
833:
428:
281:
58:
1738:
1590:
1374:
1140:
1083:
386:
Dense infiltrates of >15 mast cells in the bone marrow or an extracutaneous organ
101:
People affected by mastocytosis are susceptible to a variety of symptoms, including
3829:
3511:
3146:
2957:
2929:
1874:
1788:
1780:
1716:
1674:
1664:
1620:
1570:
1533:
1525:
1460:
1422:
1354:
1318:
1268:
1260:
1219:
1175:
1167:
1120:
1110:
1063:
1022:
1012:
971:
961:
908:
898:
823:
588:
164:
110:
1171:
879:"Case-Control Cohort Study of Patients' Perceptions of Disability in Mastocytosis"
3794:
3534:
3052:
2577:
1843:
SĂ©zary A, Levy-Coblentz G, Chauvillon P (1936). "Dermographisme et mastocytose".
1822:
Contributions to the anatomy and pathogenesis of urticaria simplex and pigmentosa
1529:
1224:
1207:
1099:"Recent advances in the understanding of mastocytosis: the role of KIT mutations"
966:
903:
299:
Mast cells seem to have other roles as well. Because they gather together around
3372:
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma syndrome
1358:
3832:
3649:
3634:
3567:
3349:
3320:
3170:
3134:
3088:
3047:
2743:
2666:
1264:
1052:"Everyday life and mastocytosis from a patient perspective-a qualitative study"
630:
620:
229:
170:
3805:
3745:
3741:
1464:
581:
antagonists block receptors targeted by leukotrienes released from mast cells.
3881:
3496:
3416:
3000:
2172:
2104:
1829:
1472:
564:
545:
515:
293:
259:
253:
134:
1769:"Reports of Medical and Surgical Practice in the Hospitals of Great Britain"
497:
highlights mast cells (darkly stained) in the mucosa of the small intestine.
3501:
3491:
3408:
2658:
1802:
1730:
1688:
1634:
1547:
1480:
1436:
1366:
1282:
1233:
1189:
1132:
1075:
1036:
985:
922:
837:
738:
466:
Diffuse cutaneous mastocytosis has diffuse involvement in which the entire
312:
308:
225:
87:
50:
1886:
1818:
Beiträge zur
Anatomie und Pathogenese der Urticaria simplex und Pigmentosa
1784:
1582:
1330:
3664:
3273:
3152:
3128:
2456:
1942:
1669:
1049:
791:
717:
696:
690:
672:
638:
608:
578:
206:
195:
2674:
1017:
3422:
3017:
2654:
1124:
1067:
855:
660:
654:
614:
604:
511:
494:
71:
46:
3709:
1721:
1704:
1625:
1608:
828:
811:
567:
block receptors targeted by histamine released from mast cells. Both H
3824:
3684:
3447:
Template:Congenital malformations and deformations of skin appendages
1960:
1845:
Bulletin de la Société Française de
Dermatologie et de Syphiligraphie
1701:
720:
can relieve skin symptoms, but may increase the risk of skin cancer.
684:
592:
531:
Systemic mastocytosis with associated hematological neoplasm (SM-AHN)
304:
289:
277:
215:
114:
83:
1443:
3860:
3402:
3287:
3099:
2445:
2186:
2037:
1096:
678:
184:
179:
125:
67:
525:
Indolent systemic mastocytosis (ISM). The most common SM (>90%)
2295:
2221:
1924:
998:
938:
875:
634:
219:
3783:
587:
help prevent mast cells from releasing their chemical contents.
3736:
3721:
3331:
3180:
Focal palmoplantar keratoderma with oral mucosal hyperkeratosis
2402:
1951:
1936:
1560:
1514:"Mastocytosis: update on pharmacotherapy and future directions"
507:
396:
Aberrant phenotype on the mast cells (pos. for CD2 and/or CD25)
363:
175:
1512:
Cardet, Juan Carlos; Akin, Cem; Lee, Min Jung (October 2013).
681:. Can have effect in rare cases without mutation in KIT(D816V)
3521:
2337:
1842:
1653:"Novel approaches to treating advanced systemic mastocytosis"
1459:(2). Archives of Pathology and Laboratory Medicine: 225–232.
503:
453:(UP), more common in children, although also seen in adults.
331:
300:
262:(due to inactivation of pancreatic enzymes by increased acid)
106:
2507:
Adult type of generalized eruption of cutaneous mastocytosis
1923:
167:, a reaction to stroking or scratching of urticaria lesions.
3849:
1650:
1408:
1097:
Orfao A, Garcia-Montero AC, Sanchez L, Escribano L (2007).
999:
Lee, JK; Whittaker, SJ; Enns, RA; Zetler, P (Dec 7, 2008).
285:
151:
102:
95:
1205:
1001:"Gastrointestinal manifestations of systemic mastocytosis"
427:
Another known but rare mast cell proliferation disease is
1343:
1153:
544:
Further information on the investigational new drug:
3595:
Congenital hypertrophy of the lateral fold of the hallux
1651:
Gilreath, JA; Tchertanov, L; Deininger, MW (July 2019).
3463:
Template:DNA replication and repair-deficiency disorder
117:
and other pro-inflammatory substances from mast cells.
1387:
James, William; Berger, Timothy; Elston, Dirk (2005).
1449:
750:
National
Institute of Allergy and Infectious Diseases
3699:
1249:"Mast cell activation: proposed diagnostic criteria"
1240:
1389:
1246:
224:Decreased bone density or increased bone density (
3079:Diffuse nonepidermolytic palmoplantar keratoderma
809:
3879:
2803:Nonbullous congenital ichthyosiform erythroderma
2428:Refractory cytopenia with multilineage dysplasia
1657:Clinical Pharmacology: Advances and Applications
1295:National Organization for Rare Disorders (NORD)
3268:Palmoplantar keratoderma and spastic paraplegia
1646:
1644:
1602:
1600:
1453:Archives of Pathology & Laboratory Medicine
521:There are five types of systemic mastocytosis:
3074:Diffuse epidermolytic palmoplantar keratoderma
2091:Accelerated phase chronic myelogenous leukemia
1253:The Journal of Allergy and Clinical Immunology
1201:
1199:
934:
932:
575:blockers may be helpful, often in combination.
443:
440:Mastocytosis can occur in a variety of forms:
399:Aberrant mast cell morphology (spindle-shaped)
292:, mast cells attract other key players of the
3605:Congenital malformations of the dermatoglyphs
2635:
1909:
1766:
1511:
854:. Mastocytosis Society Canada. Archived from
481:
1867:The American Journal of the Medical Sciences
1824:] (in German). Verlag von Leopold Voss.
1641:
1597:
296:to areas of the body where they are needed.
1196:
1147:
1090:
929:
803:
409:
3630:Melanotic neuroectodermal tumor of infancy
3367:Keratosis follicularis spinulosa decalvans
2798:Ichthyosis–sclerosing cholangitis syndrome
2642:
2628:
1916:
1902:
687:. Is being tested in trials. Not approved.
456:Telangiectasia macularis eruptiva perstans
414:Other types of mast cell disease include:
377:three minor criteria has to be fulfilled:
244:Increased stomach acid production causing
37:
3590:Congenital cartilaginous rest of the neck
3185:Focal palmoplantar and gingival keratosis
1864:
1792:
1720:
1678:
1668:
1624:
1606:
1537:
1426:
1272:
1223:
1179:
1114:
1026:
1016:
975:
965:
912:
902:
827:
3655:Rapidly involuting congenital hemangioma
3245:Keratosis punctata of the palmar creases
3240:Keratosis punctata palmaris et plantaris
3111:Clouston's hidrotic ectodermal dysplasia
1815:
1411:"Mast Cells in Gastrointestinal Disease"
1308:
852:"Mastocytosis & mast cell disorders"
644:
558:
485:
124:
2408:Refractory anemia with excess of blasts
1381:
528:Smouldering systemic mastocytosis (SSM)
3880:
1247:Akin C, Valent P, Metcalfe DD (2010).
534:Aggressive systemic mastocytosis (ASM)
2716:Congenital ichthyosiform erythroderma
2623:
1897:
810:Horny HP, Sotlar K, Valent P (2007).
370:blood using sensitive PCR-technology
120:
3377:Keratosis pilaris atrophicans faciei
2962:Dermatopathia pigmentosa reticularis
2573:Acute panmyelosis with myelofibrosis
1607:Pardanani, Animesh (November 2016).
706:Allogeneic stem cell transplantation
252:and direct histamine stimulation on
2423:Paroxysmal nocturnal hemoglobinuria
13:
3670:Superficial lymphatic malformation
3615:Congenital smooth muscle hamartoma
3084:Palmoplantar keratoderma of Sybert
2653:malformations and deformations of
2194:
1858:
1495:"Mastocytosis - Treatment Options"
380:
366:) may help confirm the diagnosis.
272:
14:
3909:
3142:Scleroatrophic syndrome of Huriez
2972:Hypohidrotic ectodermal dysplasia
1518:Expert Opinion on Pharmacotherapy
1415:Gastroenterology & Hepatology
1005:World Journal of Gastroenterology
435:
402:Finding of mutation in KIT(D816V)
390:
3255:Porokeratosis plantaris discreta
3212:Striate palmoplantar keratoderma
2148:Juvenile myelomonocytic leukemia
1879:10.1097/00000441-199506000-00007
1816:Unna, Paul Gerson; Unna (1887).
1575:10.1097/00006842-198607000-00006
1116:10.1111/j.1365-2141.2007.06619.x
812:"Mastocytosis: state of the art"
3888:Dermal and subcutaneous growths
3680:Verrucous vascular malformation
3610:Congenital preauricular fistula
3580:Accessory nail of the fifth toe
3457:Template:Pigmentation disorders
3250:Schöpf–Schulz–Passarge syndrome
3230:Acrokeratoelastoidosis of Costa
2935:Laryngoonychocutaneous syndrome
2808:Ichthyosis linearis circumflexa
2793:Ichthyosis prematurity syndrome
2413:Chromosome 5q deletion syndrome
2324:Acute megakaryoblastic leukemia
2153:Chronic myelomonocytic leukemia
2064:Myeloid dendritic cell leukemia
1836:
1809:
1760:
1745:
1695:
1554:
1505:
1487:
1402:
1337:
1302:
1289:
732:
202:from allergic or immune causes)
64:Clinical Immunology and Allergy
3294:Erythrokeratodermia variabilis
3205:Pachyonychia congenita type II
2497:Diffuse cutaneous mastocytosis
1709:American Journal of Hematology
1613:American Journal of Hematology
1043:
992:
869:
844:
49:of mastocytosis. Skin biopsy.
1:
3620:Cystic lymphatic malformation
3573:Cavernous venous malformation
3200:Pachyonychia congenita type I
3123:Corneodermatoosseous syndrome
2783:Ichthyosis bullosa of Siemens
2265:Chronic eosinophilic leukemia
2024:Chronic neutrophilic leukemia
1172:10.1158/0008-5472.CAN-16-2234
797:
754:National Institutes of Health
422:Mast cell activation syndrome
3028:Popliteal pterygium syndrome
2720:Epidermolytic hyperkeratosis
2605:Biphenotypic acute leukaemia
2540:Xanthelasmoidal mastocytosis
1767:Nettleship E, Tay W (1869).
1530:10.1517/14656566.2013.824424
1323:10.1016/1076-0512(95)00388-6
1225:10.1182/blood-2016-03-643544
967:10.1371/journal.pone.0026375
904:10.1371/journal.pone.0002266
723:
550:
405:S-tryptase >20 ng/ml
353:
192:Ear/nose/throat inflammation
7:
3660:Rosenthal–Kloepfer syndrome
3645:Omphalomesenteric duct cyst
3362:Keratolytic winter erythema
3022:Gerodermia osteodysplastica
1982:Acute myeloblastic leukemia
1359:10.1080/1042819021000037967
1056:Journal of Clinical Nursing
785:
744:
444:Cutaneous mastocytosis (CM)
113:, caused by the release of
31:Clonal bone marrow disorder
10:
3914:
3235:Focal acral hyperkeratosis
2982:Ellis–van Creveld syndrome
2502:Erythrodermic mastocytosis
2269:Hypereosinophilic syndrome
1265:10.1016/j.jaci.2010.08.035
770:
667:Tyrosine kinase inhibitors
543:
482:Systemic mastocytosis (SM)
342:). In laboratory studies,
248:(increased stimulation of
3815:
3703:
3550:
3520:
3484:
3475:
3394:
3313:
3159:Papillon–Lefèvre syndrome
3060:
3046:
2999:
2948:
2825:
2775:
2757:
2730:Harlequin-type ichthyosis
2706:
2688:
2665:
2586:
2559:
2552:
2530:
2485:
2453:
2444:
2389:
2367:
2345:
2336:
2317:Essential thrombocythemia
2303:
2294:
2285:
2251:
2229:
2220:
2185:
2165:
2134:
2112:
2103:
2072:
2045:
2036:
2010:
1968:
1959:
1950:
1935:
1465:10.5858/arpa.2013-0594-oa
57:
45:
36:
26:
21:
3033:Pseudoxanthoma elasticum
2749:Sjögren–Larsson syndrome
1929:hematological malignancy
1391:. (10th ed.). Saunders.
711:
410:Other mast cell diseases
133:When mast cells undergo
98:+ mast cell precursors.
3893:Immune system disorders
3558:Aplasia cutis congenita
2977:Focal dermal hypoplasia
2940:Skin fragility syndrome
2788:Ichthyosis follicularis
2086:Philadelphia chromosome
1347:Leukemia & Lymphoma
756:(NIH) Clinical Center.
207:very low blood pressure
3675:Thyroglossal duct cyst
3640:Nasolacrimal duct cyst
3563:Amniotic band syndrome
3357:Dyskeratosis congenita
3345:Dyskeratosis congenita
3195:Pachyonychia congenita
3106:Bart–Pumphrey syndrome
3038:Van der Woude syndrome
3013:Ehlers–Danlos syndrome
1757:, Stat, March 16, 2020
1563:Psychosomatic Medicine
599:Proton-pump inhibitors
498:
338:for stem cell factor (
209:(including shock) and
130:
3540:Nevus flammeus nuchae
3451:Template:Phakomatoses
3423:Hereditary lymphedema
2987:Rapp–Hodgkin syndrome
2676:Congenital ichthyosis
2600:Primary myelofibrosis
2532:Systemic mastocytosis
2477:Systemic mastocytosis
1785:10.1136/bmj.2.455.323
645:Cytoreductive therapy
585:Mast cell stabilizers
559:Anti-mediator therapy
489:
324:cell surface receptor
322:Mast cells express a
294:immune defense system
250:enterochromaffin cell
189:Olfactive intolerance
128:
3530:Capillary hemangioma
3432:Urticaria pigmentosa
3190:Howel–Evans syndrome
2950:Ectodermal dysplasia
2891:Generalized atrophic
2522:Solitary mastocytoma
2512:Urticaria pigmentosa
2418:Sideroblastic anemia
1670:10.2147/CPAA.S206615
780:urticaria pigmentosa
776:Urticaria pigmentosa
491:Immunohistochemistry
451:urticaria pigmentosa
360:urticaria pigmentosa
171:Abdominal discomfort
147:urticaria pigmentosa
3217:Tyrosinemia type II
2767:X-linked ichthyosis
2725:Lamellar ichthyosis
2698:Ichthyosis vulgaris
2681:erythrokeratodermia
1018:10.3748/wjg.14.7005
958:2011PLoSO...626375M
895:2008PLoSO...3.2266H
3816:External resources
3600:Congenital lip pit
3164:Haim–Munk syndrome
3116:Vohwinkel syndrome
2991:Hay–Wells syndrome
2967:Hay–Wells syndrome
2813:Ichthyosis hystrix
2739:Netherton syndrome
2467:Mast cell leukemia
2359:Erythroleukemia/M6
2243:Acute eosinophilic
1068:10.1111/jocn.14676
1062:(7–8): 1114–1124.
538:Mast cell leukemia
499:
265:Hepatosplenomegaly
131:
121:Signs and symptoms
111:anaphylactic shock
3875:
3874:
3697:
3696:
3693:
3692:
3625:Median raphe cyst
3585:Bronchogenic cyst
3507:PHACE association
3471:
3470:
3390:
3389:
3382:Keratosis pilaris
3326:Keratosis pilaris
3280:Carvajal syndrome
3260:Spiny keratoderma
2925:Costello syndrome
2821:
2820:
2617:
2616:
2613:
2612:
2548:
2547:
2517:Mast cell sarcoma
2472:Mast cell sarcoma
2440:
2439:
2436:
2435:
2403:Refractory anemia
2381:Polycythemia vera
2332:
2331:
2281:
2280:
2277:
2276:
2216:
2215:
2181:
2180:
2161:
2160:
2099:
2098:
2032:
2031:
1722:10.1002/ajh.24490
1715:(11): 1069–1075.
1626:10.1002/ajh.24553
1619:(11): 1146–1159.
1524:(15): 2033–2045.
1218:(20): 2391–2405.
829:10.1159/000101711
718:ultraviolet light
429:mast cell sarcoma
282:connective tissue
241:Ocular discomfort
77:
76:
16:Medical condition
3905:
3701:
3700:
3512:Sinus pericranii
3482:
3481:
3338:Darier's disease
3147:Olmsted syndrome
3058:
3057:
2958:Naegeli syndrome
2930:Kindler syndrome
2686:
2685:
2672:
2671:
2644:
2637:
2630:
2621:
2620:
2593:
2566:
2557:
2556:
2553:Multiple/unknown
2533:
2490:
2460:
2451:
2450:
2396:
2374:
2352:
2343:
2342:
2310:
2301:
2300:
2292:
2291:
2258:
2236:
2227:
2226:
2208:Acute basophilic
2201:
2192:
2191:
2141:
2119:
2110:
2109:
2079:
2052:
2043:
2042:
2017:
1975:
1966:
1965:
1957:
1956:
1948:
1947:
1918:
1911:
1904:
1895:
1894:
1890:
1853:
1852:
1840:
1834:
1833:
1813:
1807:
1806:
1796:
1764:
1758:
1749:
1743:
1742:
1724:
1699:
1693:
1692:
1682:
1672:
1648:
1639:
1638:
1628:
1604:
1595:
1594:
1558:
1552:
1551:
1541:
1509:
1503:
1502:
1491:
1485:
1484:
1447:
1441:
1440:
1430:
1406:
1400:
1385:
1379:
1378:
1341:
1335:
1334:
1306:
1300:
1293:
1287:
1286:
1276:
1244:
1238:
1237:
1227:
1203:
1194:
1193:
1183:
1166:(6): 1261–1270.
1151:
1145:
1144:
1118:
1094:
1088:
1087:
1047:
1041:
1040:
1030:
1020:
996:
990:
989:
979:
969:
936:
927:
926:
916:
906:
873:
867:
866:
864:
863:
848:
842:
841:
831:
807:
589:Cromoglicic acid
334:), which is the
284:, including the
41:
19:
18:
3913:
3912:
3908:
3907:
3906:
3904:
3903:
3902:
3878:
3877:
3876:
3871:
3870:
3811:
3810:
3712:
3698:
3689:
3551:Other/ungrouped
3546:
3535:Port-wine stain
3516:
3477:
3467:
3386:
3309:
3051:
3042:
2995:
2944:
2829:
2817:
2771:
2753:
2702:
2679:
2661:
2648:
2618:
2609:
2587:
2582:
2578:Myeloid sarcoma
2560:
2544:
2531:
2526:
2486:
2481:
2454:
2432:
2390:
2385:
2368:
2363:
2346:
2328:
2304:
2273:
2252:
2247:
2230:
2212:
2195:
2177:
2157:
2135:
2130:
2113:
2095:
2073:
2068:
2046:
2028:
2011:
2006:
1969:
1940:
1931:
1922:
1861:
1859:Further reading
1856:
1841:
1837:
1814:
1810:
1765:
1761:
1751:Garde, Damian,
1750:
1746:
1700:
1696:
1649:
1642:
1605:
1598:
1559:
1555:
1510:
1506:
1501:. 25 June 2012.
1493:
1492:
1488:
1448:
1444:
1421:(12): 772–777.
1407:
1403:
1386:
1382:
1342:
1338:
1307:
1303:
1294:
1290:
1259:(6): 1099–104.
1245:
1241:
1204:
1197:
1160:Cancer Research
1152:
1148:
1103:Br. J. Haematol
1095:
1091:
1048:
1044:
997:
993:
937:
930:
874:
870:
861:
859:
850:
849:
845:
808:
804:
800:
788:
773:
747:
735:
726:
716:Treatment with
714:
647:
631:Antidepressants
621:Corticosteroids
574:
570:
561:
553:
548:
484:
446:
438:
412:
393:
383:
381:Major criterion
356:
315:). No one with
280:are located in
275:
273:Pathophysiology
165:"Darier's Sign"
156:dermatographic
123:
17:
12:
11:
5:
3911:
3901:
3900:
3895:
3890:
3873:
3872:
3869:
3868:
3857:
3846:
3835:
3820:
3819:
3817:
3813:
3812:
3809:
3808:
3797:
3786:
3775:
3767:
3748:
3729:
3713:
3708:
3707:
3705:
3704:Classification
3695:
3694:
3691:
3690:
3688:
3687:
3682:
3677:
3672:
3667:
3662:
3657:
3652:
3650:Poland anomaly
3647:
3642:
3637:
3635:Mongolian spot
3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3576:
3575:
3570:
3568:Branchial cyst
3565:
3560:
3554:
3552:
3548:
3547:
3545:
3544:
3543:
3542:
3532:
3526:
3524:
3518:
3517:
3515:
3514:
3509:
3504:
3499:
3494:
3488:
3486:
3479:
3473:
3472:
3469:
3468:
3442:
3441:
3436:
3435:
3434:
3425:
3413:
3412:
3411:
3398:
3396:
3392:
3391:
3388:
3387:
3385:
3384:
3379:
3374:
3369:
3364:
3359:
3353:
3352:
3350:Lelis syndrome
3347:
3342:
3341:
3340:
3328:
3323:
3321:Meleda disease
3317:
3315:
3311:
3310:
3308:
3307:
3306:
3305:
3296:
3284:
3283:
3282:
3270:
3263:
3262:
3257:
3252:
3247:
3242:
3237:
3232:
3222:
3221:
3220:
3219:
3214:
3209:
3208:
3207:
3202:
3192:
3187:
3182:
3173:
3171:Camisa disease
3168:
3167:
3166:
3161:
3149:
3144:
3139:
3138:
3137:
3135:Naxos syndrome
3125:
3120:
3119:
3118:
3113:
3108:
3092:
3091:
3089:Meleda disease
3086:
3081:
3076:
3066:
3064:
3055:
3048:Hyperkeratosis
3044:
3043:
3041:
3040:
3035:
3030:
3025:
3015:
3009:
3007:
2997:
2996:
2994:
2993:
2984:
2979:
2974:
2969:
2964:
2954:
2952:
2946:
2945:
2943:
2942:
2937:
2932:
2927:
2920:
2919:
2918:
2917:
2912:
2901:
2900:
2899:
2898:
2893:
2888:
2883:
2872:
2871:
2870:
2869:
2864:
2859:
2854:
2849:
2844:
2833:
2831:
2823:
2822:
2819:
2818:
2816:
2815:
2810:
2805:
2800:
2795:
2790:
2785:
2779:
2777:
2773:
2772:
2770:
2769:
2763:
2761:
2755:
2754:
2752:
2751:
2746:
2744:CHIME syndrome
2741:
2735:
2734:
2733:
2732:
2722:
2712:
2710:
2704:
2703:
2701:
2700:
2694:
2692:
2683:
2669:
2667:Genodermatosis
2663:
2662:
2647:
2646:
2639:
2632:
2624:
2615:
2614:
2611:
2610:
2608:
2607:
2602:
2596:
2594:
2584:
2583:
2581:
2580:
2575:
2569:
2567:
2554:
2550:
2549:
2546:
2545:
2543:
2542:
2536:
2534:
2528:
2527:
2525:
2524:
2519:
2514:
2509:
2504:
2499:
2493:
2491:
2483:
2482:
2480:
2479:
2474:
2469:
2463:
2461:
2448:
2442:
2441:
2438:
2437:
2434:
2433:
2431:
2430:
2425:
2420:
2415:
2410:
2405:
2399:
2397:
2387:
2386:
2384:
2383:
2377:
2375:
2365:
2364:
2362:
2361:
2355:
2353:
2340:
2334:
2333:
2330:
2329:
2327:
2326:
2320:
2319:
2313:
2311:
2298:
2289:
2283:
2282:
2279:
2278:
2275:
2274:
2272:
2271:
2261:
2259:
2249:
2248:
2246:
2245:
2239:
2237:
2224:
2218:
2217:
2214:
2213:
2211:
2210:
2204:
2202:
2189:
2183:
2182:
2179:
2178:
2176:
2175:
2169:
2167:
2163:
2162:
2159:
2158:
2156:
2155:
2150:
2144:
2142:
2132:
2131:
2129:
2128:
2122:
2120:
2107:
2101:
2100:
2097:
2096:
2094:
2093:
2088:
2082:
2080:
2070:
2069:
2067:
2066:
2061:
2055:
2053:
2040:
2034:
2033:
2030:
2029:
2027:
2026:
2020:
2018:
2008:
2007:
2005:
2004:
1999:
1994:
1989:
1984:
1978:
1976:
1963:
1954:
1945:
1933:
1932:
1921:
1920:
1913:
1906:
1898:
1892:
1891:
1873:(6): 328–338.
1860:
1857:
1855:
1854:
1835:
1808:
1779:(455): 323–4.
1759:
1744:
1694:
1640:
1596:
1569:(6): 437–447.
1553:
1504:
1486:
1442:
1401:
1380:
1353:(2): 313–319.
1336:
1301:
1297:"Mastocytosis"
1288:
1239:
1195:
1146:
1089:
1042:
1011:(45): 7005–8.
991:
952:(10): e26375.
928:
868:
843:
801:
799:
796:
795:
794:
787:
784:
772:
769:
760:mastocytosis.
746:
743:
739:orphan disease
734:
731:
725:
722:
713:
710:
703:
702:
701:
700:
694:
693:- 60% respond.
688:
682:
676:
664:
658:
646:
643:
628:
627:
624:
618:
612:
602:
596:
582:
576:
572:
568:
565:Antihistamines
560:
557:
552:
549:
542:
541:
535:
532:
529:
526:
483:
480:
476:
475:
464:
460:
445:
442:
437:
436:Classification
434:
433:
432:
425:
419:
411:
408:
407:
406:
403:
400:
397:
392:
391:Minor criteria
389:
388:
387:
382:
379:
355:
352:
274:
271:
267:
266:
263:
257:
242:
239:
236:
233:
230:osteosclerosis
222:
213:
203:
193:
190:
187:
182:
173:
168:
162:
161:(skin writing)
144:Skin lesions (
142:
122:
119:
86:disease, is a
75:
74:
61:
55:
54:
43:
42:
34:
33:
28:
24:
23:
15:
9:
6:
4:
3:
2:
3910:
3899:
3898:Rare diseases
3896:
3894:
3891:
3889:
3886:
3885:
3883:
3867:
3863:
3862:
3858:
3856:
3852:
3851:
3847:
3845:
3841:
3840:
3836:
3834:
3831:
3827:
3826:
3822:
3821:
3818:
3814:
3807:
3803:
3802:
3798:
3796:
3792:
3791:
3787:
3785:
3781:
3780:
3776:
3773:
3772:
3768:
3766:
3762:
3758:
3757:
3753:
3749:
3747:
3743:
3739:
3738:
3734:
3730:
3728:
3724:
3723:
3719:
3715:
3714:
3711:
3706:
3702:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3577:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3555:
3553:
3549:
3541:
3538:
3537:
3536:
3533:
3531:
3528:
3527:
3525:
3523:
3519:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3497:Encephalocele
3495:
3493:
3490:
3489:
3487:
3483:
3480:
3476:Developmental
3474:
3466:
3465:
3464:
3459:
3458:
3453:
3452:
3448:
3440:
3439:Hailey–Hailey
3437:
3433:
3429:
3426:
3424:
3421:
3420:
3419:
3418:
3417:immune system
3414:
3410:
3407:
3406:
3405:
3404:
3400:
3399:
3397:
3393:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3354:
3351:
3348:
3346:
3343:
3339:
3336:
3335:
3334:
3333:
3329:
3327:
3324:
3322:
3319:
3318:
3316:
3312:
3304:
3300:
3297:
3295:
3292:
3291:
3290:
3289:
3285:
3281:
3278:
3277:
3276:
3275:
3271:
3269:
3265:
3264:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3227:
3224:
3223:
3218:
3215:
3213:
3210:
3206:
3203:
3201:
3198:
3197:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3177:
3174:
3172:
3169:
3165:
3162:
3160:
3157:
3156:
3155:
3154:
3150:
3148:
3145:
3143:
3140:
3136:
3133:
3132:
3131:
3130:
3126:
3124:
3121:
3117:
3114:
3112:
3109:
3107:
3104:
3103:
3102:
3101:
3097:
3096:
3094:
3093:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3071:
3068:
3067:
3065:
3063:
3059:
3056:
3054:
3053:keratinopathy
3049:
3045:
3039:
3036:
3034:
3031:
3029:
3026:
3023:
3019:
3016:
3014:
3011:
3010:
3008:
3006:
3002:
2998:
2992:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2959:
2956:
2955:
2953:
2951:
2947:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2922:
2921:
2916:
2913:
2911:
2908:
2907:
2906:
2903:
2902:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2878:
2877:
2874:
2873:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2848:
2845:
2843:
2840:
2839:
2838:
2835:
2834:
2832:
2828:
2824:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2780:
2778:
2774:
2768:
2765:
2764:
2762:
2760:
2756:
2750:
2747:
2745:
2742:
2740:
2737:
2736:
2731:
2728:
2727:
2726:
2723:
2721:
2717:
2714:
2713:
2711:
2709:
2705:
2699:
2696:
2695:
2693:
2691:
2687:
2684:
2682:
2677:
2673:
2670:
2668:
2664:
2660:
2656:
2652:
2645:
2640:
2638:
2633:
2631:
2626:
2625:
2622:
2606:
2603:
2601:
2598:
2597:
2595:
2592:
2591:
2585:
2579:
2576:
2574:
2571:
2570:
2568:
2565:
2564:
2558:
2555:
2551:
2541:
2538:
2537:
2535:
2529:
2523:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2498:
2495:
2494:
2492:
2489:
2484:
2478:
2475:
2473:
2470:
2468:
2465:
2464:
2462:
2459:
2458:
2452:
2449:
2447:
2443:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
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2400:
2398:
2395:
2394:
2388:
2382:
2379:
2378:
2376:
2373:
2372:
2366:
2360:
2357:
2356:
2354:
2351:
2350:
2344:
2341:
2339:
2335:
2325:
2322:
2321:
2318:
2315:
2314:
2312:
2309:
2308:
2302:
2299:
2297:
2293:
2290:
2288:
2284:
2270:
2266:
2263:
2262:
2260:
2257:
2256:
2250:
2244:
2241:
2240:
2238:
2235:
2234:
2228:
2225:
2223:
2219:
2209:
2206:
2205:
2203:
2200:
2199:
2193:
2190:
2188:
2184:
2174:
2173:Histiocytosis
2171:
2170:
2168:
2164:
2154:
2151:
2149:
2146:
2145:
2143:
2140:
2139:
2133:
2127:
2124:
2123:
2121:
2118:
2117:
2111:
2108:
2106:
2105:Myelomonocyte
2102:
2092:
2089:
2087:
2084:
2083:
2081:
2078:
2077:
2071:
2065:
2062:
2060:
2057:
2056:
2054:
2051:
2050:
2044:
2041:
2039:
2035:
2025:
2022:
2021:
2019:
2016:
2015:
2009:
2003:
2000:
1998:
1995:
1993:
1990:
1988:
1985:
1983:
1980:
1979:
1977:
1974:
1973:
1967:
1964:
1962:
1958:
1955:
1953:
1949:
1946:
1944:
1938:
1934:
1930:
1926:
1919:
1914:
1912:
1907:
1905:
1900:
1899:
1896:
1888:
1884:
1880:
1876:
1872:
1868:
1863:
1862:
1850:
1846:
1839:
1831:
1827:
1823:
1819:
1812:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1774:
1770:
1763:
1756:
1755:
1748:
1740:
1736:
1732:
1728:
1723:
1718:
1714:
1710:
1706:
1698:
1690:
1686:
1681:
1676:
1671:
1666:
1662:
1658:
1654:
1647:
1645:
1636:
1632:
1627:
1622:
1618:
1614:
1610:
1603:
1601:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1557:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1508:
1500:
1496:
1490:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1446:
1438:
1434:
1429:
1424:
1420:
1416:
1412:
1405:
1398:
1397:0-7216-2921-0
1394:
1390:
1384:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1340:
1332:
1328:
1324:
1320:
1316:
1312:
1311:Dermatol Surg
1305:
1298:
1292:
1284:
1280:
1275:
1270:
1266:
1262:
1258:
1254:
1250:
1243:
1235:
1231:
1226:
1221:
1217:
1213:
1209:
1202:
1200:
1191:
1187:
1182:
1177:
1173:
1169:
1165:
1161:
1157:
1150:
1142:
1138:
1134:
1130:
1126:
1122:
1117:
1112:
1108:
1104:
1100:
1093:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1046:
1038:
1034:
1029:
1024:
1019:
1014:
1010:
1006:
1002:
995:
987:
983:
978:
973:
968:
963:
959:
955:
951:
947:
943:
935:
933:
924:
920:
915:
910:
905:
900:
896:
892:
888:
884:
880:
872:
858:on 2013-12-28
857:
853:
847:
839:
835:
830:
825:
822:(2): 121–32.
821:
817:
813:
806:
802:
793:
790:
789:
783:
781:
777:
768:
765:
761:
757:
755:
751:
742:
740:
730:
721:
719:
709:
707:
698:
695:
692:
689:
686:
683:
680:
677:
674:
671:
670:
668:
665:
662:
659:
656:
652:
651:
650:
642:
640:
636:
632:
625:
622:
619:
616:
613:
610:
606:
603:
600:
597:
594:
590:
586:
583:
580:
577:
566:
563:
562:
556:
547:
546:Bezuclastinib
539:
536:
533:
530:
527:
524:
523:
522:
519:
517:
516:enterocolitis
513:
509:
505:
496:
492:
488:
479:
473:
469:
465:
461:
458:
457:
452:
448:
447:
441:
430:
426:
423:
420:
417:
416:
415:
404:
401:
398:
395:
394:
385:
384:
378:
376:
371:
367:
365:
361:
358:Diagnosis of
351:
349:
345:
341:
337:
333:
329:
325:
320:
318:
314:
310:
309:blood vessels
306:
302:
297:
295:
291:
287:
283:
279:
270:
264:
261:
260:Malabsorption
258:
255:
254:parietal cell
251:
247:
246:peptic ulcers
243:
240:
237:
234:
231:
227:
223:
221:
217:
214:
212:
208:
204:
201:
197:
194:
191:
188:
186:
183:
181:
177:
174:
172:
169:
166:
163:
160:
159:
153:
149:
148:
143:
140:
139:
138:
136:
135:degranulation
127:
118:
116:
112:
108:
104:
99:
97:
93:
89:
88:rare disorder
85:
81:
73:
69:
65:
62:
60:
56:
52:
51:H&E stain
48:
44:
40:
35:
32:
29:
25:
20:
3859:
3855:mastocytosis
3848:
3844:mastocytosis
3837:
3823:
3799:
3788:
3777:
3769:
3750:
3731:
3716:
3502:Nasal glioma
3492:Dermoid cyst
3461:
3455:
3444:
3443:
3428:Mastocytosis
3427:
3415:
3409:EEM syndrome
3401:
3330:
3286:
3272:
3151:
3127:
3098:
2659:skin disease
2588:
2561:
2488:Mastocytosis
2487:
2476:
2455:
2391:
2369:
2347:
2305:
2253:
2231:
2196:
2136:
2114:
2074:
2047:
2012:
1970:
1943:granulocytes
1870:
1866:
1848:
1844:
1838:
1821:
1817:
1811:
1776:
1772:
1762:
1752:
1747:
1712:
1708:
1697:
1660:
1656:
1616:
1612:
1566:
1562:
1556:
1521:
1517:
1507:
1498:
1489:
1456:
1452:
1445:
1418:
1414:
1404:
1388:
1383:
1350:
1346:
1339:
1314:
1310:
1304:
1291:
1256:
1252:
1242:
1215:
1211:
1163:
1159:
1149:
1109:(1): 12–30.
1106:
1102:
1092:
1059:
1055:
1045:
1008:
1004:
994:
949:
945:
889:(5): e2266.
886:
882:
871:
860:. Retrieved
856:the original
846:
819:
816:Pathobiology
815:
805:
779:
775:
774:
766:
762:
758:
748:
736:
733:Epidemiology
727:
715:
704:
648:
629:
554:
520:
500:
477:
472:homme orange
471:
454:
450:
439:
413:
374:
372:
368:
359:
357:
347:
343:
339:
327:
321:
316:
313:angiogenesis
298:
276:
268:
226:osteoporosis
205:Episodes of
157:
145:
132:
129:Mastocytosis
100:
91:
82:, a type of
80:Mastocytosis
79:
78:
30:
22:Mastocytosis
3665:Skin dimple
3274:desmoplakin
3266:ungrouped:
3153:Cathepsin C
3129:plakoglobin
2830:and related
2457:Mastocytoma
1317:(1): 33–7.
1125:10261/62846
792:Mastocytoma
697:Avapritinib
691:Midostaurin
673:Midostaurin
639:mirtazapine
609:anaphylaxis
605:Epinephrine
579:Leukotriene
512:lymph nodes
220:muscle pain
196:Anaphylaxis
27:Other names
3882:Categories
3801:DiseasesDB
3095:syndromic
3018:Cutis laxa
3005:Connective
2655:integument
2651:Congenital
1941:and other
1499:Cancer.Net
862:2017-11-02
798:References
661:Cladribine
655:interferon
615:Salbutamol
468:integument
278:Mast cells
238:Depression
92:mastocytes
72:hematology
47:Micrograph
3825:eMedicine
3685:Birthmark
3478:anomalies
3445:see also
2923:related:
2776:Ungrouped
1961:Myelocyte
1927:-related
1851:: 359–61.
1830:840287852
1663:: 77–92.
1473:1543-2165
724:Prognosis
685:Masitinib
593:Ketotifen
551:Treatment
354:Diagnosis
305:histamine
290:histamine
211:faintness
158:urticaria
115:histamine
84:mast cell
59:Specialty
3861:Orphanet
3833:med/1401
3830:derm/258
3774:: 9741/3
3403:cadherin
3288:connexin
3226:punctate
3100:connexin
2446:CFU-Mast
2187:CFU-Baso
2038:Monocyte
1803:20745623
1773:Br Med J
1739:24088671
1731:27428296
1689:31372066
1635:27762455
1591:37335288
1548:24044484
1481:25611105
1437:21301631
1375:30459720
1367:12688351
1283:21035176
1234:27069254
1190:28254862
1141:12120327
1133:17555444
1084:52298220
1076:30230078
1037:19058339
986:22031830
946:PLOS ONE
923:18509466
883:PLOS ONE
838:17587883
786:See also
745:Research
679:Imatinib
336:receptor
235:Headache
185:Diarrhea
180:vomiting
68:Oncology
3795:D008415
3485:Midline
3070:diffuse
3001:Elastic
2296:CFU-Meg
2222:CFU-Eos
2059:AMoL/M5
1925:Myeloid
1887:7771504
1794:2260962
1680:6630092
1583:3749421
1539:4362676
1428:3033552
1331:8556255
1274:3753019
1181:5354959
1028:2773867
977:3198767
954:Bibcode
914:2386235
891:Bibcode
771:History
635:doxepin
317:too few
152:itching
141:Fatigue
103:itching
3784:154800
3761:757.33
3332:ATP2A2
2896:JEB-PA
2867:EBS-MP
2862:EBS-MD
2857:EBS-OG
2852:EBS-DM
2847:EBS-WC
2002:APL/M3
1952:CFU-GM
1937:CFU-GM
1885:
1828:
1801:
1791:
1737:
1729:
1687:
1677:
1633:
1589:
1581:
1546:
1536:
1479:
1471:
1435:
1425:
1395:
1373:
1365:
1329:
1299:, 2017
1281:
1271:
1232:
1188:
1178:
1139:
1131:
1082:
1074:
1035:
1025:
984:
974:
921:
911:
836:
669:(TKI)
508:spleen
364:biopsy
301:wounds
176:Nausea
154:, and
109:, and
94:) and
3866:98292
3771:ICD-O
3765:202.6
3746:C96.2
3742:Q82.2
3522:Nevus
3395:Other
3314:Other
3176:focal
2886:Mitis
2881:JEB-H
2842:EBS-K
2338:CFU-E
2166:Other
2138:MD-MP
1820:[
1735:S2CID
1587:S2CID
1371:S2CID
1212:Blood
1137:S2CID
1080:S2CID
712:Other
571:and H
540:(MCL)
504:liver
495:c-KIT
463:trunk
348:c-kit
332:CD117
328:c-kit
200:shock
107:hives
3850:GARD
3839:NORD
3806:7864
3790:MeSH
3779:OMIM
3756:9-CM
3727:2A21
2915:RDEB
2910:DDEB
1883:PMID
1826:OCLC
1799:PMID
1727:PMID
1685:PMID
1631:PMID
1579:PMID
1544:PMID
1477:PMID
1469:ISSN
1433:PMID
1393:ISBN
1363:PMID
1327:PMID
1279:PMID
1230:PMID
1186:PMID
1129:PMID
1072:PMID
1033:PMID
982:PMID
919:PMID
834:PMID
637:and
510:and
493:for
286:skin
216:Bone
178:and
96:CD34
3752:ICD
3733:ICD
3718:ICD
3303:KID
3299:HID
3062:PPK
2905:DEB
2876:JEB
2837:EBS
2563:AML
2349:AML
2287:MEP
2233:AML
2198:AML
2116:AML
2076:CML
2049:AML
1972:AML
1875:doi
1871:309
1789:PMC
1781:doi
1717:doi
1675:PMC
1665:doi
1621:doi
1571:doi
1534:PMC
1526:doi
1461:doi
1457:139
1423:PMC
1355:doi
1319:doi
1269:PMC
1261:doi
1257:126
1220:doi
1216:127
1176:PMC
1168:doi
1121:hdl
1111:doi
1107:138
1064:doi
1023:PMC
1013:doi
972:PMC
962:doi
909:PMC
899:doi
824:doi
344:scf
340:scf
228:or
218:or
150:),
3884::
3864::
3853::
3842::
3828::
3804::
3793::
3782::
3763:,
3759::
3744:,
3740::
3737:10
3725::
3722:11
3460:,
3454:,
3449:,
3228::
3178::
3072::
2827:EB
2759:XR
2718::
2708:AR
2690:AD
2657:/
2590:MP
2393:MD
2371:MP
2307:MP
2255:MP
2126:M4
2014:MP
1997:M2
1992:M1
1987:M0
1881:.
1869:.
1849:43
1847:.
1797:.
1787:.
1775:.
1771:.
1733:.
1725:.
1713:91
1711:.
1707:.
1683:.
1673:.
1661:11
1659:.
1655:.
1643:^
1629:.
1617:91
1615:.
1611:.
1599:^
1585:.
1577:.
1567:48
1565:.
1542:.
1532:.
1522:14
1520:.
1516:.
1497:.
1475:.
1467:.
1455:.
1431:.
1417:.
1413:.
1369:.
1361:.
1351:44
1349:.
1325:.
1315:22
1313:.
1277:.
1267:.
1255:.
1251:.
1228:.
1214:.
1210:.
1198:^
1184:.
1174:.
1164:77
1162:.
1158:.
1135:.
1127:.
1119:.
1105:.
1101:.
1078:.
1070:.
1060:28
1058:.
1054:.
1031:.
1021:.
1009:14
1007:.
1003:.
980:.
970:.
960:.
948:.
944:.
931:^
917:.
907:.
897:.
885:.
881:.
832:.
820:74
818:.
814:.
653:É‘-
506:,
375:or
326:,
105:,
70:,
66:,
3754:-
3735:-
3720:-
3710:D
3430:/
3301:/
3050:/
3024:)
3020:(
3003:/
2989:/
2960:/
2678:/
2643:e
2636:t
2629:v
2267:/
1939:/
1917:e
1910:t
1903:v
1889:.
1877::
1832:.
1805:.
1783::
1777:2
1741:.
1719::
1691:.
1667::
1637:.
1623::
1593:.
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