735:
instead. On August 15, 2023, Mallinckrodt announced that they were preparing to file for their second
Chapter 11 bankruptcy filing in three years after failing to make scheduled payments to its lenders and opioid creditors since June, sighting numerous short-term extensions to its payment within the last two months. Mallinckrodt is currently in negotiations to establish a restructuring support agreement with its stakeholders, and the payment was also extended once again to next week. Mallinckrodt stated that there would be no guaranteed recovery for holders of its ordinary equity shares in the eventuality of a bankruptcy filing .
399:. Compton urgently needed a source of refined uranium. The chemical company already worked with ether, which could theoretically be used in a purifying process but which posed its own handling risks. With extreme haste and with tight security restrictions, Mallinckrodt developed a novel technique from theoretical concept, to experiment, to full production. The company submitted test materials by mid-May, supplied the material for the first self-sustaining reaction in December, and had satisfied the project's entire order of the first sixty tons before the contract with the government was even signed.
593:
350:
922:. Mallinckrodt acquired this product via its acquisition of Questcor Pharmaceuticals in 2014. When Questcor acquired the drug in 2001 it sold for $ 40 a vial; within a year of the acquisition Questcor raised the price of the drug to $ 1,500 per vial and to $ 28,000 by 2013. In 2013, Questcor acquired the US rights to a competing product, Synacthen Depot, from Novartis. In 2014 Mallinckrodt raised the price of Acthar further to $ 34,000. The
34:
267:
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872:. Chief Financial Officer, Matthew Harbaugh, will head the new company which will retain the Mallinckrodt name. The remaining business of specialty branded products will be renamed and led by current Chief Executive Officer, Mark Trudeau. Legal liabilities that result from opioid litigation are expected to be the responsibility of Mallinckrodt Inc. or its subsidiaries following the separation.
346:. The Mallinckrodt family had immigrated from Germany. Otto and Edward both temporarily returned to Germany, then the leader in chemical research and education, for advanced training. Brothers Gustav and Otto died in the 1870s, leaving Edward (1845–1928) in sole charge of the family business. Mallinckrodt Chemical Works was incorporated 15 years later, in 1882.
709:
oxycodone possession and sale in those areas. Negotiations between the DEA and
Mallinckrodt ensued, and in 2017 Mallinckrodt paid a $ 35 million fine to settle DEA complaints it did not adequately address suspicious opioid orders, acknowledging "certain aspects of Mallinckrodt's system to monitor and detect suspicious orders did not meet" DEA standards.
1936:
increased 10-fold and totaled $ 1.3 billion from 2011 to 2015, it found. On top of that, the research letter published this week in JAMA Internal
Medicine found that Acthar prescriptions often were written by a relatively small number of frequent prescribers, raising questions about how it is being marketed to those doctors by Mallinckrodt.
516:(TCJA), but that some of these benefits would be offset by the anti-inversion provisions of the TCJA. In April 2018, Mallinckrodt's Irish tax inversion came under further scrutiny when it was revealed that Mallinckrodt's main drug, Acthar, was one of the most expensive drug-related expenditures for the U.S. Medicare programme.
727:
Mallinckrodt got an extension on their $ 200 million payment with a new due date of June 23, 2023. On June 23, the day the payment was supposed to be due, Mallinckrodt got their payment due date extended for the second time to June 30, 2023. It later got delayed to July 7, 2023, and again to July 14, 2023.
730:
On July 11, 2023, Mallinckrodt was sued for allegedly misleading investors for misrepresenting its financial strength before missing payments to opioid victims and bond holders. On July 14, Mallinckrodt's $ 200 million opioid payment was once again extended to July 21. On July 17, it was extended yet
1830:
In an interview with
Bloomberg TV on Thursday, Mr Chanos said he expects Congress will call for a review of Mallinckrodt pricing at some point. Asked to put a value on the company, Mr Chanos said: "We think it is zero." Acthar is the most "egregiously" overpriced drug in the United States, he said,
1774:
Under the law, U.S. earnings will be taxed at 21%, down from 35%. Citing the lower rate, Mallinckrodt PLC, a drug company based in the U.K. but with about 90% of its sales in the U.S., said it expects the law to be "neutral to slightly positive." Mallinckrodt said in recent security filing it would
1215:
Pharma firm
Mallinckrodt has agreed to buy Questcor Pharmaceuticals for $ 5.6bn (€4bn) to add specialty drugs in the latest industry deal that moves a US company to Ireland for a lower tax rate. Mallinckrodt, with a registered headquarters in Dublin and run from Hazelwood, Missouri, will pay $ 86.08
738:
On August 23, after losing approximately 92% of their stock value in 2023, Mallinckrodt officially announced their intention to file for
Chapter 11 protection within the coming days in order to reduce the amount of long-term debt it owes to victims of the opioid crisis and cut its debt obligations.
1935:
The research from the Oregon State
University's College of Pharmacy found that the blockbuster drug's more than $ 1 billion in sales have been paid for primarily by Medicare and Medicaid for conditions that often could be treated with less expensive corticosteroids. Spending by Medicare for Acthar
755:
On
November 14, 2023, Mallinckrodt reduced its total funded debt by approximately $ 1.9 billion after winning approval for its bankruptcy plan to ample liquidity to execute strategic priorities back in October, and announced that it has completed its second Chapter 11 reorganization and has exited
1805:
A new lawsuit from a former employee at
Mallinckrodt Pharmaceuticals claims exactly that. The drug in question is called Acthar. It costs about $ 40,000 and is mainly used to treat infantile spasms. Somehow, though, the drug has become one of the biggest drug-related expenditures for Medicare, a
726:
On June 2, 2023, Mallinckrodt announced that they would be considering a second
Chapter 11 bankruptcy protection filing after lenders of the company raised concerns over an upcoming $ 200 million payment related to opioid-related litigation that was due in the coming weeks. However, on June 16,
325:
Mallinckrodt acquires (for repricing), manufactures, and distributes products used in diagnostic procedures and in the treatment of pain and related conditions. This includes the acquisition, manufacture, and distribution of specialty pharmaceuticals, active pharmaceutical ingredients, contrast
1723:
Horizon and other inverted companies are using their new, lower tax rates to turbocharge corporate takeovers. Applying those rates, often in the midteens, to profits of companies in the U.S., with a federal corporate rate of 35%, can yield extra savings on top of those traditionally wrung from
712:
Mallinckrodt announced in April 2019 a plan to change its name to Sonorant Therapeutics, and spin off "Mallinckrodt Inc." as a separate company for its generics business. Legal liabilities that result from opioid litigation would "remain with Mallinckrodt Inc. or its subsidiaries following the
704:
database tracking every opioid pill sold in the United States from 2006 through 2012 was made public in 2019. The database "attributed the vast majority of the 76 billion opioid pills produced and shipped from 2006 through 2012 to three companies", one of which was SpecGx, a subsidiary of
747:
for the second time in three years in effort to dramatically cut its debt load and reduce its sweeping opioid settlement. Immediately after the announcement, the NYSE halted Mallinckrodt's stock, and its stock was delisted from the New York Stock Exchange soon thereafter, and began trading on
734:
On July 27, 2023, Mallinckrodt announced that they were in negotiations to completely avoid paying the opioid payment to victims. If this plan turns out successful, victims of the opioid payment could lose up to a maximum of $ 1 billion, and the money could end up going to funds and investors
606:, in an article on Mallinckrodt's main drug H.P. Acthar Gel, reported: "How the price of this drug rose so far, so fast is a story for these troubled times in American health care—a tale of aggressive marketing, questionable medicine and, not least, out-of-control costs". In January 2017, the
708:
In 2011 the DEA complained to Mallinckrodt about the problem of excessive prescription opioid shipments to pharmacies. DEA officials showed the company the hundreds of millions of doses of oxycodone it was shipping to distributors and the correspondingly high number of arrests being made for
688:. Medicaid Rules required Mallinckrodt to pay back the amount it had raised the price of Achtar above inflation. To avoid meeting its increased rebate obligations, Mallinckrodt began reporting Acthar’s base AMP as if it had been approved in 2010 (after the enormous price increases).
926:
and attorneys general from five states sued Mallinckrodt for anti-competitive behavior with regard to the acquisition of Synacthen Depot and the monopolistic pricing of Acthar, and in January 2017 the company settled, agreeing to pay $ 100 million and to license Synacthen Depot to a
491:
to Ireland to avoid U.S. corporate taxes, by acquiring Irish-based Cadence Pharma for $ 1.3 billion. This was despite the fact that almost all of Mallinckrodt's revenues come from the U.S. market (see table below). In 2015, Mallinckrodt was one of several U.S. tax inversions that
867:
In December 2018 the company announced it will spin off its specialty generics business into a separate publicly traded company, initially owned by existing Mallinckrodt shareholders. The division generated $ 840 million in 2017 and the deal will also include constipation drug,
691:
In October 2020, Mallinckrodt filed for bankruptcy, which stayed the pending False Claims Act case. On March 2, 2022, the bankruptcy court confirmed Mallinckrodt’s plan of reorganization, which included the settlement of the whistleblower's lawsuit for $ 234 million.
616:(FTC) in relation to antitrust probes on Acthar and quoted the FTC as saying: "Questcor took advantage of its monopoly to repeatedly raise the price of Acthar, from $ 40 per vial in 2001 to more than $ 34,000 per vial today – an 85,000 percent increase". The city of
1874:
Drug company Mallinckrodt saw its shares end the day down nearly 6 per cent on Wednesday after it announced it would pay $ 100m to resolve antitrust probes into the market for a type of drug that treats a rare infant seizure disorder and other serious medical
1747:
Mallinckrodt, which has a tax address in Ireland, said that it will pay a tax rate of 15 per cent to 17 per cent in 2016. That low tax rate can give the company an advantage when seeking acquisitions, though Trudeau said that's not the primary impetus for
674:
process as Acthar had been available for 60 years and was thus passed under FDA "grandfathering" rules, had an unknown formulation and efficacy. The lawsuit claimed that this situation would not be sustainable without the support of Express Scripts.
647:
quoted Chanos on Bloomberg stating that a "murky alliance" had developed between Mallinckrodt and distributor Express Scripts, who is the sole distributor of Acthar, and that "Acthar is the epitome of excessive drug prices". In September 2017, the
310:), generic drugs and imaging agents. In 2017, it generated 90% of its sales from the U.S. healthcare system. While Mallinckrodt is headquartered in Ireland for tax purposes, its operational headquarters are in the U.S. Mallinckrodt's 2013
462:. Both Edward Mallinckrodt Sr. and Jr. served as members of the Washington University Board of Trustees. Washington University in St. Louis' student union building and performing arts building was renamed the Mallinckrodt Center in 1976.
465:
In 2018, Mallinckrodt partnered with the Washington University School of Medicine with funding of up to $ 10 million over five years to support research projects that show promise in developing new drugs for treating rare diseases.
1287:
504:
reported the CEO as saying that "It'd have to be a pretty dramatic change to the US tax code" for Mallinckrodt to return to the U.S., and that "We're already foreign domiciled, so we may as well take full advantage of it".
739:
The company has also entered into a new restructuring agreement with its creditors and an opioid victims trust. On August 28, 2023, Mallinckrodt and some of its affiliated debtors filed a voluntary petition under
662:
system, but that most sales of Acthar were "driven in part by a relatively small group of doctors who were prescribing it heavily", and that alternatives at one-fiftieth of the price of Acthar were available.
855:
2017 – In September, Mallinckrodt acquired specialty pharmaceutical company, InfaCare Pharmaceutical Corporation. In November the company announced its intention to acquire Ocera Therapeutics for up to $
1724:
mergers. Moreover, unlike the U.S., Ireland and most other countries, only tax profits earned in-country, giving companies the freedom and incentive to shift income to still-lower-tax jurisdictions.
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H.P. Acthar Gel represents a little over one-third of Mallinckrodt's sales; however, its strong profitability means that it is considered to be responsible for the bulk of Mallinckrodt's profits.
1450:
2150:
2228:
3165:
1775:
get a $ 450 million to $ 500 million deferred tax benefit from the lower U.S. corporate rate, which would "mostly be offset" by the new limitations on interest-expense deductions.
2358:
705:
Mallinckrodt. In those years SpecGx supplied 28.9 billion oxycodone pills, more than 80 for each person in the United States, and over 2 billion pills just in Florida.
454:
has received a large number of donations from the Mallinckrodt family and corporation, including a posthumous endowment by Edward Mallinckrodt Jr. on behalf of his father to the
3195:
3190:
3185:
326:
products, and radiopharmaceuticals. The company employed 5,500 and had net sales of $ 3.2 billion in 2017, of which $ 2.9 billion was from the U.S. healthcare system.
813:
2011 – Covidien announced plans to spin off Mallinckrodt Pharmaceuticals, and Mallinckrodt Plc was separated on June 28, 2013, trading on the ticker MNK from July 1, 2013.
3004:
2306:
2098:
884:
Specialty Pharmaceuticals products include branded drugs as well as specialty generics and active pharmaceutical ingredients (APIs). Products include biologics, medicinal
406:
into weapons-grade uranium at a factory north of downtown St. Louis. Nuclear waste from the factory and other locations was buried in steel drums at a 21.7-acre site near
498:
reported to be using a lower tax-platform to acquire further U.S. pharmaceutical firms, such as the $ 5.6 billion acquisition of Questor in 2014. In December 2015,
2410:
2384:
744:
716:
In February 2020, the company struck a $ 1.6 billion deal with Florida and dozens of other states to settle lawsuits over its role in the US opioid crisis.
2826:
1089:
482:
311:
2855:
3160:
2436:
2869:
1821:
2631:
823:
488:
329:
The company has been implicated as a major contributor to the prescription opioid scandal around the over-prescription of oxycodone in the United States.
2332:
2202:
2176:
2894:
2488:
2967:
2941:
2122:
2920:
2716:
1691:
772:
435:
1796:
430:
The company issued public shares in 1954. Viewed as an attractive takeover target in the era of leveraged buyouts, Mallinckrodt was bought by
81:
1797:"'There's other s--- in the vial': Bombshell lawsuit claims no one knows exactly what's in a drug that's cost the government over $ 1 billion"
2280:
1963:
1394:
1206:
1057:
injection), an iodide based contrast medium for CT scans, and Optimark (gadoversetamide injection) a Gadolinium-Based Contrast Agent used in
419:
3175:
3026:
2778:
1844:
650:
2812:
1476:
997:
solid in two forms – a liquid-suspension oral concentrate, Mallinckrodt brand name Methadose™, and as generic 40mg Methadone HCl tablets
903:
In the fourth quarter of 2014, Specialty Pharmaceuticals accounted for 74% of net sales. Key specialty pharmaceutical products include:
411:
2798:
1930:
1642:
1172:
684:
action in 2018 alleging that Mallinckrodt failed to pay the correct Medicaid rebates for Acthar in violation of the federal and state
1494:
596:
Price of Mallinckrodt's H.P Acthar drug dating back to Questor's acquisition of Acthar from Sanofi Aventis in July 2001 for $ 100,000
3099:
1736:
3180:
1233:
907:
740:
455:
375:, Edward Mallinckrodt Sr. assigned one of the company's top chemists to collaborate in developing the first radiographic agent for
315:
307:
930:
Ofirmev is a proprietary IV formulation of acetaminophen used in conjunction with opioid painkillers in the post surgical setting.
829:
2014 – Mallinckrodt acquired Questcor Pharmaceuticals for $ 5.6 billion (owner of Acthar); Mallinckrodt joins the S&P 500
1045:
Other compounded medications which combine some of the aforementioned drugs with acetaminophen/paracetamol or ibuprofen, such as
407:
3045:
1762:
1618:
806:
2007 – Tyco Healthcare spun off as Covidien, an independent company. The healthcare business units were spun off under the name
756:
bankruptcy. Ownership of Mallinckrodt will be handed over to lenders and bondholders and all remaining equity sales would end.
2737:
2462:
1888:
2254:
2760:"Mallinckrodt Set to Join the S&P 500; Rowan to Join S&P MidCap 400; GulfMark Offshore to Join S&P SmallCap 600"
1582:
1908:
1711:
1518:"'Atomic Fallout': Records reveal government downplayed, ignored health risks of St. Louis radioactive waste for decades"
459:
1517:
2560:
1260:
451:
193:
2986:
723:
protection while facing more than $ 1 billion in costs from lawsuits over its role in fueling the opioid crisis.
2834:
1153:
1122:
Acthar is a hormone-based drug derived from pig pituitary glands that had been on the market for more than 60 years.
933:
Xartemis XR is a controlled release oral combination of acetaminophen and oxycodone for the treatment of acute pain.
363:
By 1898, the company had established itself as a pharmaceuticals supplier and in 1913 became the first to introduce
1451:"Coldwater Creek, St Louis: The area of Missouri under investigation after 'unusual' numbers of rare cancers found"
1424:
2512:
2925:
2605:
2565:
701:
438:. After re-brandings, spin-offs and other changes of corporate identity Mallinckrodt was again sold in 2000 to
2694:
2600:
2546:
1234:"The most respected medical journal in the US just eviscerated a drug that's cost taxpayers over $ 1 billion"
1000:
513:
470:
20:
1560:
342:
In 1867, the three Mallinckrodt brothers, Gustav, Otto and Edward Sr., founded G. Mallinckrodt & Co. in
3137:
2652:
944:
Mallinckrodt specializes in producing generic controlled substances and compounds. Their products include:
2580:
899:
Medical Imaging products include contrast media and radiopharmaceuticals for medical imaging applications.
621:
371:
for x-rays. In part due to early success in production of radiology agents, and at the behest of surgeon
2945:
1058:
3081:
1806:
government health insurance program for old people. In 2015, Medicare spent $ 500 million on the drug.
2827:"Guerbet completes acquisition of Mallinckrodt's Contrast Media and Delivery Systems business (CMDS)"
1425:"The Poisoned Children of Coldwater Creek: St. Louis' nuclear legacy may be graver than anyone knows"
2619:
2074:
2050:
2026:
1977:
1831:
adding that he expects it will be replaced by generics in 10 years or that pricing will be lowered.
923:
659:
613:
469:
The elder Edward also made significant donations to his alma mater, Harvard University, and to the
388:
1865:
3170:
2856:"Mallinckrodt Plans to Purchase Skin Substitute Developer Stratatech - GEN News Highlights - GEN"
2657:
2493:
2001:
1914:
1768:
1717:
1177:
1046:
860:
796:
1996 – Mallinckrodt acquired maker of urology imaging systems and injectors, Liebel-Flarsheim Co.
494:
70:
1094:
948:
44:
1667:
1310:
787:
as the only company to receive an exception from the DEA for cocaine possession and processing
654:(JAMA) published research showing that Acthar was one of the most expensive drugs in the U.S.
1948:
1334:, vol. 3, edited by Giles R. Hoyt. German Historical Institute. Last modified March 10, 2015.
1327:
889:
720:
434:
in 1982, and largely kept intact as a business entity. Just four years later it was sold to
372:
1183:
842:
2015 – Mallinckrodt sold the Contrast Media and Deliver Systems portion of its portfolio to
2127:
836:
396:
1345:
8:
3005:"Maker of $ 34,000-a-vial drug to pay $ 100 million for allegedly preventing competition"
1292:
1288:"Little-known makers of generic drugs played central role in opioid crisis, records show"
1077:
633:
144:
134:
2517:
1849:
915:
822:
2013 – Mallinckrodt acquired Cadence Pharmaceuticals for £1.3 billion in an Irish
800:
783:
617:
602:
439:
2695:"Mallinckrodt plc Completes $ 1.3 Billion Acquisition of Cadence Pharmaceuticals, Inc"
2961:
2870:"Mallinckrodt Bags InfaCare And Its Late-Stage Lead Drug In Deal Worth $ 425 Million"
2585:
2522:
1375:
1367:
1332:
Immigrant Entrepreneurship: German-American Business Biographies, 1720 to the Present
1256:
1210:
1069:
1064:
As of 1988, Mallinckrodt was the only company in the U.S. that is allowed to receive
959:
911:
749:
641:
accused Mallinckrodt in relation to Acthar of being a "one-product company", and the
612:
reported that Mallinckrodt had made a settlement of $ 100 million with the U.S.
392:
61:
3100:"Mallinckrodt Pharmaceuticals – Compounding Powders – Cocaine Hydrochloride USP CII"
2099:"Drugmaker Mallinckrodt reaches $ 1.6B opioid settlement with Florida, other states"
819:
2013 – Mallinckrodt spun off from Covidien and began trading under ticker symbol MNK
816:
2012 – Mallinckrodt announced acquisition of CNS Therapeutics for $ 100 million
2680:
1800:
1357:
1237:
1073:
685:
376:
259:
1964:"Mallinckrodt used 'dirty data' to snow payers on Acthar, whistleblower suit says"
306:
is an American-Irish domiciled manufacturer of specialty pharmaceuticals (namely,
2721:
1869:
1593:
919:
625:
608:
500:
368:
87:
3027:"Questcor's Acthar maneuvers land Mallinckrodt in hot water with FTC, state AGs"
1539:
2783:
2636:
364:
98:
65:
1495:"St. Louis Airport/Hazelwood Interim Storage/Futura Coatings of St. Louis, Mo"
835:
2015 – Mallinckrodt acquired Therakos for $ 1.325 billion (later sold to
3154:
3132:
2526:
1792:
1371:
988:
984:
937:
893:
776:
667:
431:
52:
592:
3046:"Company Raises the Price of a Drug That Fights Infant Epilepsy by 85,000%"
2799:"Mallinckrodt to Acquire Therakos for $ 1.325B - GEN News Highlights - GEN"
1379:
2203:"Mallinckrodt gets second $ 200 million opioid payment deadline extension"
1362:
483:
Corporation tax in the Republic of Ireland § Corporate tax inversions
387:
In April 1942 Edward Mallinckrodt was approached by a contingent from the
2763:
1866:"Mallinckrodt shares fall after it announces $ 100m antitrust settlement"
1825:
1741:
1695:
978:
963:
847:
643:
403:
3142:
1395:"The Mallinckrodt Chemical Works Story, 1962:The First 50 Critical Days"
1039:
1015:
638:
216:
2942:"Mallinckrodt to spin off generics business, but to keep options open"
2229:"Mallinckrodt gets another extension for $ 200 million opioid payment"
1286:
Davis, Aaron C.; Boburg, Shawn; O'Harrow Jr., Robert (July 26, 2019).
349:
2921:"Sucampo Pharmaceuticals closes on its $ 1.2B sale to a U.K. company"
1030:
1025:
1021:
994:
852:
2016 – Mallinckrodt acquired regenerative medicine company Stratatech
512:
that it would get a $ 450 to $ 500 million tax credits from the
415:
343:
2672:
2561:"TIMELINE: Mallinckrodt over the years - St. Louis Business Journal"
2123:"Major opioid maker Mallinckrodt files for bankruptcy amid lawsuits"
1931:"JAMA piece resurrects questions over cost of Mallinckrodt's Acthar"
1643:"Mallinckrodt boosts rare-disease research at Washington University"
33:
2895:"Mallinckrodt to Acquire Ocera Therapeutics for Up to $ 117M - GEN"
2333:"Mallinckrodt aims to avoid paying an opioid settlement to victims"
2177:"Mallinckrodt gets $ 200 million opioid payment deadline extension"
1892:
1054:
1006:
972:
967:
914:
used for the treatment of infantile spasms, acute exacerbations of
807:
655:
319:
2307:"Mallinckrodt gets another extension on opioid settlement payment"
1346:"Roentgenologic Examination of the Gallbladder (Cholecystography)"
2813:"Mallinckrodt to sell Therakos unit to CVC Capital for $ 925 mln"
1592:. State Historical Society of Missouri. p. 2. Archived from
1065:
1034:
954:
869:
843:
680:
2151:"Mallinckrodt considers second bankruptcy filing, other options"
793:
1995 – Mallinckrodt established generic pharmaceuticals business
3121:
2281:"Mallinckrodt says opioid trust further extending payment date"
1010:
885:
832:
2015 – Mallinckrodt acquired Ikaria Inc. for $ 2.3 billion
138:
128:
2779:"Mallinckrodt Buys Ikaria for $ 2.3 Billion for Neonatal Care"
2632:"Covidien Spinning Off Drugs Unit to Focus on Pain Management"
2359:"Drugmaker Mallinckrodt moves toward second bankruptcy filing"
1822:"Mallinckrodt shorted by US investment group over Acthar drug"
1583:"S0452 Mallinckrodt, Edward Jr. (1878–1967) Papers, 1798–1981"
1416:
445:
239:
2411:"Mallinckrodt goes bankrupt amid debt-cut plan, opioid deal"
2002:"Medicaid Drug Rebate Program Explained | Whistleblower Law"
1311:"SHSMO-St. Louis s0452 Mallinckrodt, Edward Jr. (1878–1967)"
2676:
2385:"Mallinckrodt to file for second bankruptcy in coming days"
1285:
1760:
Rockoff, Jonathan D.; Trentmann, Nina (11 February 2018).
765:
1981 – Mallinckrodt was listed among Fortune 500 companies
292:
1763:"New Tax Law Haunts Companies That Did 'Inversion' Deals"
1477:"Missouri school to close after radioactive waste report"
745:
United States District Court for the District of Delaware
671:
520:
Mallinckrodt net sales by region (SEC 10-K filing, 2017)
3166:
Companies formerly listed on the New York Stock Exchange
1887:
Farmer, Brit McCandless; Siddiqi, Ayesha (12 May 2019).
670:
lawsuit claimed Acthar, which had never passed a modern
2738:"Mallinckrodt Agrees to Buy Questcor for $ 5.6 Billion"
3196:
Companies traded over-the-counter in the United States
3191:
Companies that filed for Chapter 11 bankruptcy in 2023
3186:
Companies that filed for Chapter 11 bankruptcy in 2020
2255:"Mallinckrodt sued for allegedly misleading investors"
458:
Radiology Department resulting in the creation of the
1692:"Deal-based pharm firm Mallinckrodt in $ 5.6 bn deal"
1647:
Washington University School of Medicine in St. Louis
1167:
1165:
1163:
3082:"Mallinckrodt Pharmaceuticals – Compounding Powders"
2717:"Deal-based pharm firm Mallinkrodt in $ 5.6 bn deal"
2437:"NYSE: Mallinckrodt in Regulatory Halt Pending News"
1889:"60 Minutes reports: prescription drug price fixing"
1442:
1257:"SEC Form 10-K: Mallinckrodt public limited company"
1207:"Mallinckrodt agrees deal to exploit Irish tax base"
1907:
1761:
1710:
1449:Eleftheriou-Smith, Loulla-Mae (October 28, 2015).
1404:. National Museum of Nuclear Science & History
1182:
1160:
1148:
1146:
1144:
1142:
1140:
1138:
476:
2735:
2673:"Covidien completes $ 100M CNS Therapeutics deal"
2573:
1909:"Jim Chanos Predicts Stock Drop for Mallinckrodt"
1590:State Historical Society of Missouri: Manuscripts
1563:. St. Louis Post-Dispatch (subscription required)
1561:"What's in a Name? Mallinckrodt Goes Back to Inc"
1448:
1154:"News & Media - Mallinckrodt Pharmaceuticals"
382:
3152:
2736:Armstrong, Drew; Serafino, Phil (7 April 2014).
2651:Kamp, Jon; Pollock, Lauren (December 15, 2011).
2620:Reuters press release Mon Jul 2, 2007 4:29pm EDT
2601:"Tyco Healthcare completes spin-off as Covidien"
2463:"Drugmaker Mallinckrodt emerges from bankruptcy"
1787:
1785:
1783:
1759:
1305:
1303:
768:1982 – Avon Products, Inc. acquired Mallinckrodt
1961:
1672:. Pharmaceutical Age. 30 July 1908. p. 131
1509:
1497:. United States Environmental Protection Agency
1386:
1216:a share for Anaheim, California-based Questcor.
1135:
859:2018 – In February 2018, Mallinckrodt acquired
775:(IMCERA Group Inc.) acquired Mallinckrodt from
773:International Minerals and Chemical Corporation
436:International Minerals and Chemical Corporation
2981:
2979:
2977:
2940:Mathias, Saumya Joseph, Tamara (Dec 6, 2018).
1842:
966:salts which together form the brand name drug
410:. Radioactive waste from the site seeped into
314:to Ireland drew controversy when it was shown
3020:
3018:
1886:
1791:
1780:
1300:
1281:
1279:
1277:
1275:
1273:
3161:Pharmaceutical companies established in 1867
2966:: CS1 maint: multiple names: authors list (
2581:"Tyco to Buy Mallinckrodt for $ 3.2 Billion"
1845:"Questcor Finds Profits, at $ 28,000 a Vial"
936:Exalgo is a once-daily, long-acting form of
628:for their failure to reduce Acthar's price.
2998:
2996:
2974:
2650:
1928:
651:Journal of the American Medical Association
3015:
2776:
2489:"Mallinckrodt: a timeline : Business"
1540:"Our Story | Mallinckrodt Pharmaceuticals"
1270:
1228:
1226:
1224:
1053:Medical imaging products include Optiray (
446:Ties to Washington University in St. Louis
402:From 1942 to 1957, Mallinckrodt processed
32:
1905:
1361:
880:Mallinckrodt has two main product lines.
3003:Johnson, Carolyn Y. (January 18, 2017).
2993:
1422:
1033:– a.k.a. meperidine; common brand name:
846:for $ 270M cash with a loan financed by
719:In October 2020, Mallinckrodt filed for
702:US Drug Enforcement Administration (DEA)
695:
591:
508:In February 2018, Mallinckrodt told the
456:Washington University School of Medicine
348:
3002:
2939:
2506:
2504:
1863:
1737:"Mallinckrodt won't give up Irish home"
1708:
1316:. State Historical Society of Missouri.
1221:
1024:– as API and tablets common brand name
3153:
3043:
3024:
1712:"The Tax Inversion Wave Keeps Rolling"
1558:
1474:
1251:
1249:
1247:
1003:(common brand names Ritalin, Concerta)
1816:
1814:
1343:
759:
587:
2918:
2501:
1515:
1393:Ruhoff, John (as told to Pat Fain).
1018:– common brand names Revia, Vivitrol
781:1988 – Malinckrodt was mentioned in
741:Chapter 11 of the United States Code
425:
3176:Pharmaceutical companies of Ireland
2510:
1843:Andrew Pollock (29 December 2012).
1559:Steyer, Robert (9 September 1996).
1244:
460:Mallinckrodt Institute of Radiology
13:
1906:Zuckerman, Gregory (18 May 2017).
1811:
1623:Washington University in St. Louis
1392:
1261:Securities and Exchange Commission
452:Washington University in St. Louis
14:
3207:
3113:
2777:McLaughlin, Kim (March 5, 2012).
1962:Eric Sagonowsky (13 April 2018).
1929:Eric Palmer (13 September 2017).
487:In 2013, Mallinckrodt executed a
377:gallbladder and bile duct imaging
3128:Business data for Mallinckrodt:
2919:Reed, Tina (February 13, 2018).
2653:"Covidien to Spin Off Drug Unit"
2513:"How Coca-Cola Obtains Its Coca"
1475:Salter, Jim (October 18, 2022).
1265:Results of Operations: Net Sales
839:for $ 925 million in 2024.)
790:1992 – Malinckrodt owned HemoCue
620:, is now suing Mallinckrodt and
304:Mallinckrodt Pharmaceuticals plc
266:
265:
246:
245:
224:
223:
201:
200:
180:
179:
27:Mallinckrodt Pharmaceuticals plc
3181:1867 establishments in Missouri
3092:
3074:
3056:
3044:Galeon, Dom (21 January 2017).
3037:
3025:Staton, Tracy (June 18, 2015).
2933:
2926:American City Business Journals
2912:
2887:
2862:
2848:
2819:
2805:
2791:
2770:
2752:
2729:
2709:
2687:
2665:
2644:
2624:
2613:
2606:American City Business Journals
2593:
2566:American City Business Journals
2553:
2539:
2511:May, Clifford D. (1988-07-01).
2481:
2455:
2429:
2403:
2377:
2351:
2325:
2299:
2273:
2247:
2221:
2195:
2169:
2143:
2115:
2091:
2079:Whistleblower Law Collaborative
2067:
2055:Whistleblower Law Collaborative
2043:
2031:Whistleblower Law Collaborative
2019:
2006:Whistleblower Law Collaborative
1994:
1982:Whistleblower Law Collaborative
1970:
1955:
1941:
1922:
1899:
1880:
1857:
1836:
1753:
1729:
1702:
1684:
1660:
1635:
1611:
1575:
1552:
1532:
1516:Kite, Allison (July 12, 2023).
1487:
1468:
1344:Evens, Ronald G. (2009-01-07).
1116:
1107:
477:Tax inversion to Ireland (2013)
420:Environmental Protection Agency
3064:"Mallinckrodt Pharmaceuticals"
2697:. Yahoo Finance. 19 March 2014
2075:"Mallinckrodt - $ 234 Million"
2051:"Mallinckrodt - $ 234 Million"
2027:"Mallinckrodt - $ 234 Million"
1978:"Mallinckrodt - $ 234 Million"
1423:Hartmann, Ray (May 22, 2013).
1337:
1320:
1199:
547:Europe, Middle East and Africa
383:Uranium processing (1942–1957)
16:Irish domiciled pharmaceutical
1:
1181:. 1 July 2013. Archived from
1129:
1061:(MRI) of the brain or liver.
1001:Methylphenidate hydrochloride
514:Tax Cuts and Jobs Act of 2017
471:St. Louis College of Pharmacy
354:
21:Mallinckrodt (disambiguation)
3104:Mallinckrodt Pharmaceuticals
3086:Mallinckrodt Pharmaceuticals
3068:Mallinckrodt Pharmaceuticals
1709:Hoffman, Liz (7 July 2015).
637:reported that U.S. investor
414:. The area was designated a
110:; 157 years ago
7:
2956:– via uk.reuters.com.
1951:. FiercePharma. April 2014.
1083:
875:
622:pharmacy benefit management
308:adrenocorticotropic hormone
10:
3212:
2815:. Reuters. August 5, 2024.
1402:Atomic Heritage Foundation
1072:for use in hospitals as a
1059:magnetic resonance imaging
962:– one of four constituent
480:
337:
332:
18:
1328:"Edward Mallinckrodt Sr."
287:
277:
257:
237:
214:
191:
175:
153:
122:
104:
94:
80:
50:
40:
31:
1100:
1090:Corporate tax inversions
924:Federal Trade Commission
678:A whistleblower filed a
614:Federal Trade Commission
450:Throughout its history,
389:Metallurgical Laboratory
322:'s most expensive drug.
2658:The Wall Street Journal
2494:St. Louis Post-Dispatch
2259:The Wall Street Journal
1915:The Wall Street Journal
1769:The Wall Street Journal
1718:The Wall Street Journal
1178:The Wall Street Journal
1047:hydrocodone/paracetamol
861:Sucampo Pharmaceuticals
824:corporate tax inversion
495:The Wall Street Journal
489:corporate tax inversion
1095:Ireland as a tax haven
1007:Naloxone Hydrochloride
951:– brand name Suboxone™
949:Buprenorphine/naloxone
597:
360:
162:Paul Bisaro (chairman)
1619:"Mallinckrodt Center"
1520:. MuckRock Foundation
1363:10.1001/jama.2008.893
1068:, which is sold as a
890:controlled substances
826:to escape U.S. taxes.
803:acquired Mallinckrodt
721:Chapter 11 bankruptcy
696:Role in opioid crisis
595:
353:Edward Mallinckrodt,
352:
230:US$ 1.67 billion
2640:. December 15, 2011.
2569:. December 15, 2011.
2547:"HemoCue Milestones"
2497:. December 16, 2011.
1240:. 12 September 2017.
1078:ear, nose and throat
1009:– common brand name
987:(common brand name:
940:, another pain drug.
837:CVC Capital Partners
731:again to August 15.
397:Arthur Holly Compton
165:Siggi Olafsson (CEO)
19:For other uses, see
2948:on December 6, 2018
2683:. 11 November 2012.
2549:. 14 November 2018.
2469:. November 14, 2023
1745:. 8 December 2015.
1293:The Washington Post
1187:on 10 December 2013
634:Wall Street Journal
521:
510:Wall Street Journal
279:Number of employees
168:Bryan Reasons (CFO)
145:Hazelwood, Missouri
135:Staines-upon-Thames
28:
2518:The New York Times
1850:The New York Times
1429:St. Louis Magazine
916:multiple sclerosis
801:Tyco International
784:The New York Times
760:Major acquisitions
618:Rockford, Illinois
603:The New York Times
600:In December 2012,
598:
588:Acthar controversy
519:
440:Tyco International
395:, particularly by
361:
147:, US (operational)
26:
2858:. 11 August 2016.
2801:. 10 August 2015.
2766:. 14 August 2014.
2762:(Press release).
2586:Los Angeles Times
2443:. August 28, 2023
2417:. August 28, 2023
2391:. August 23, 2023
2365:. August 15, 2023
2131:. 12 October 2020
1949:"H.P. Acthar Gel"
1795:(11 April 2018).
1326:Mercelis, Joris.
1211:Irish Independent
1070:prescription drug
1049:(a.k.a. Vicodin).
960:Dextroamphetamine
912:biopharmaceutical
856:117 million.
686:False Claims Acts
666:In April 2018, a
631:In May 2017, the
585:
584:
531:Distribution (%)
426:Corporate changes
393:Manhattan Project
301:
300:
131:, Ireland (legal)
3203:
3125:
3124:
3122:Official website
3108:
3107:
3096:
3090:
3089:
3078:
3072:
3071:
3060:
3054:
3053:
3041:
3035:
3034:
3022:
3013:
3012:
3000:
2991:
2990:
2983:
2972:
2971:
2965:
2957:
2955:
2953:
2944:. Archived from
2937:
2931:
2930:
2916:
2910:
2909:
2907:
2905:
2891:
2885:
2884:
2882:
2880:
2866:
2860:
2859:
2852:
2846:
2845:
2843:
2842:
2833:. Archived from
2823:
2817:
2816:
2809:
2803:
2802:
2795:
2789:
2788:
2774:
2768:
2767:
2756:
2750:
2749:
2747:
2745:
2733:
2727:
2726:
2713:
2707:
2706:
2704:
2702:
2691:
2685:
2684:
2681:Associated Press
2669:
2663:
2662:
2648:
2642:
2641:
2628:
2622:
2617:
2611:
2610:
2597:
2591:
2590:
2589:. June 29, 2000.
2577:
2571:
2570:
2557:
2551:
2550:
2543:
2537:
2536:
2534:
2533:
2508:
2499:
2498:
2485:
2479:
2478:
2476:
2474:
2459:
2453:
2452:
2450:
2448:
2433:
2427:
2426:
2424:
2422:
2407:
2401:
2400:
2398:
2396:
2381:
2375:
2374:
2372:
2370:
2355:
2349:
2348:
2346:
2344:
2329:
2323:
2322:
2320:
2318:
2303:
2297:
2296:
2294:
2292:
2277:
2271:
2270:
2268:
2266:
2251:
2245:
2244:
2242:
2240:
2225:
2219:
2218:
2216:
2214:
2199:
2193:
2192:
2190:
2188:
2173:
2167:
2166:
2164:
2162:
2147:
2141:
2140:
2138:
2136:
2119:
2113:
2112:
2110:
2109:
2095:
2089:
2088:
2086:
2085:
2071:
2065:
2064:
2062:
2061:
2047:
2041:
2040:
2038:
2037:
2023:
2017:
2016:
2014:
2013:
1998:
1992:
1991:
1989:
1988:
1974:
1968:
1967:
1959:
1953:
1952:
1945:
1939:
1938:
1933:. FiercePharma.
1926:
1920:
1919:
1911:
1903:
1897:
1896:
1884:
1878:
1877:
1861:
1855:
1854:
1840:
1834:
1833:
1818:
1809:
1808:
1801:Business Insider
1789:
1778:
1777:
1765:
1757:
1751:
1750:
1733:
1727:
1726:
1714:
1706:
1700:
1699:
1688:
1682:
1681:
1679:
1677:
1664:
1658:
1657:
1655:
1654:
1639:
1633:
1632:
1630:
1629:
1615:
1609:
1608:
1606:
1604:
1598:
1587:
1579:
1573:
1572:
1570:
1568:
1556:
1550:
1549:
1547:
1546:
1536:
1530:
1529:
1527:
1525:
1513:
1507:
1506:
1504:
1502:
1491:
1485:
1484:
1472:
1466:
1465:
1463:
1461:
1446:
1440:
1439:
1437:
1435:
1420:
1414:
1413:
1411:
1409:
1399:
1390:
1384:
1383:
1365:
1341:
1335:
1324:
1318:
1317:
1315:
1307:
1298:
1297:
1283:
1268:
1267:
1253:
1242:
1241:
1238:Business Insider
1230:
1219:
1218:
1213:. 8 April 2014.
1203:
1197:
1196:
1194:
1192:
1186:
1169:
1158:
1157:
1150:
1123:
1120:
1114:
1111:
1074:local anesthetic
910:, an injectable
522:
518:
359:
356:
297:
294:
272:
271:US$ 1.16 billion
269:
268:
262:
252:
251:US$ 3.73 billion
249:
248:
242:
233:
231:
227:
226:
210:
208:
204:
203:
194:Operating income
186:
185:US$ 1.87 billion
183:
182:
141:, UK (executive)
118:
116:
111:
90:
36:
29:
25:
3211:
3210:
3206:
3205:
3204:
3202:
3201:
3200:
3151:
3150:
3147:
3120:
3119:
3116:
3111:
3098:
3097:
3093:
3080:
3079:
3075:
3062:
3061:
3057:
3042:
3038:
3023:
3016:
3009:Washington Post
3001:
2994:
2985:
2984:
2975:
2959:
2958:
2951:
2949:
2938:
2934:
2917:
2913:
2903:
2901:
2893:
2892:
2888:
2878:
2876:
2868:
2867:
2863:
2854:
2853:
2849:
2840:
2838:
2831:www.guerbet.com
2825:
2824:
2820:
2811:
2810:
2806:
2797:
2796:
2792:
2775:
2771:
2758:
2757:
2753:
2743:
2741:
2734:
2730:
2725:. 7 April 2014.
2722:The Irish Times
2715:
2714:
2710:
2700:
2698:
2693:
2692:
2688:
2671:
2670:
2666:
2649:
2645:
2630:
2629:
2625:
2618:
2614:
2609:. July 2, 2007.
2599:
2598:
2594:
2579:
2578:
2574:
2559:
2558:
2554:
2545:
2544:
2540:
2531:
2529:
2509:
2502:
2487:
2486:
2482:
2472:
2470:
2461:
2460:
2456:
2446:
2444:
2435:
2434:
2430:
2420:
2418:
2409:
2408:
2404:
2394:
2392:
2383:
2382:
2378:
2368:
2366:
2357:
2356:
2352:
2342:
2340:
2339:. July 27, 2023
2331:
2330:
2326:
2316:
2314:
2313:. July 17, 2023
2305:
2304:
2300:
2290:
2288:
2287:. July 14, 2023
2279:
2278:
2274:
2264:
2262:
2261:. July 11, 2023
2253:
2252:
2248:
2238:
2236:
2227:
2226:
2222:
2212:
2210:
2209:. June 23, 2023
2201:
2200:
2196:
2186:
2184:
2183:. June 16, 2023
2175:
2174:
2170:
2160:
2158:
2149:
2148:
2144:
2134:
2132:
2121:
2120:
2116:
2107:
2105:
2103:Tampa Bay Times
2097:
2096:
2092:
2083:
2081:
2073:
2072:
2068:
2059:
2057:
2049:
2048:
2044:
2035:
2033:
2025:
2024:
2020:
2011:
2009:
2000:
1999:
1995:
1986:
1984:
1976:
1975:
1971:
1966:. FiercePharma.
1960:
1956:
1947:
1946:
1942:
1927:
1923:
1904:
1900:
1885:
1881:
1870:Financial Times
1862:
1858:
1841:
1837:
1828:. 19 May 2017.
1820:
1819:
1812:
1790:
1781:
1758:
1754:
1735:
1734:
1730:
1707:
1703:
1698:. 7 April 2014.
1690:
1689:
1685:
1675:
1673:
1666:
1665:
1661:
1652:
1650:
1641:
1640:
1636:
1627:
1625:
1617:
1616:
1612:
1602:
1600:
1599:on 21 July 2016
1596:
1585:
1581:
1580:
1576:
1566:
1564:
1557:
1553:
1544:
1542:
1538:
1537:
1533:
1523:
1521:
1514:
1510:
1500:
1498:
1493:
1492:
1488:
1473:
1469:
1459:
1457:
1455:The Independent
1447:
1443:
1433:
1431:
1421:
1417:
1407:
1405:
1397:
1391:
1387:
1342:
1338:
1325:
1321:
1313:
1309:
1308:
1301:
1284:
1271:
1255:
1254:
1245:
1232:
1231:
1222:
1205:
1204:
1200:
1190:
1188:
1171:
1170:
1161:
1152:
1151:
1136:
1132:
1127:
1126:
1121:
1117:
1112:
1108:
1103:
1086:
1080:(ENT) doctors.
981:API and tablets
920:orphan diseases
878:
762:
698:
626:Express Scripts
609:Financial Times
590:
501:The Irish Times
485:
479:
448:
428:
412:Coldwater Creek
385:
369:contrast medium
357:
340:
335:
291:
280:
270:
258:
250:
238:
229:
222:
219:
207:US$ 538 million
206:
199:
196:
184:
171:
156:
114:
112:
109:
86:
76:
55:
24:
17:
12:
11:
5:
3209:
3199:
3198:
3193:
3188:
3183:
3178:
3173:
3171:Tax inversions
3168:
3163:
3149:
3148:
3146:
3145:
3140:
3135:
3129:
3126:
3115:
3114:External links
3112:
3110:
3109:
3091:
3073:
3055:
3036:
3014:
2992:
2973:
2932:
2911:
2886:
2861:
2847:
2818:
2804:
2790:
2784:Bloomberg News
2769:
2751:
2728:
2708:
2686:
2664:
2643:
2637:Bloomberg News
2623:
2612:
2592:
2572:
2552:
2538:
2500:
2480:
2454:
2428:
2402:
2376:
2350:
2324:
2298:
2272:
2246:
2235:. July 7, 2023
2233:MarketScreener
2220:
2194:
2168:
2157:. June 5, 2023
2142:
2114:
2090:
2066:
2042:
2018:
1993:
1969:
1954:
1940:
1921:
1898:
1879:
1856:
1835:
1810:
1779:
1752:
1728:
1701:
1683:
1659:
1634:
1610:
1574:
1551:
1531:
1508:
1486:
1467:
1441:
1415:
1385:
1356:(1): 100–101.
1336:
1319:
1299:
1269:
1263:. p. 51.
1243:
1220:
1198:
1173:"Mallinckrodt"
1159:
1133:
1131:
1128:
1125:
1124:
1115:
1105:
1104:
1102:
1099:
1098:
1097:
1092:
1085:
1082:
1051:
1050:
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