257:
in 1959. However, it was later realized that Ochoa's enzyme did not use DNA to synthesize RNA but instead formed arbitrary sequences, and later this enzyme was found to degrade RNA in cells. Undeterred by Ochoa's findings, Hurwitz searched for a cellular RNA polymerase on his own and in 1960 he
264:
extracts. Remarkably, several other research groups reported similar discoveries at roughly the same time (Samuel B. Weiss, Audrey
Stevens, and James Bonner). Hurwitz continued his research on RNA synthesis, and in 1962 Hurwitz, John J. Furth, and Monika Anders reported the purification of RNA
276:
also worked on how the DNA of single-stranded DNA virus became replicated. They identified the enzymes that converted single-stranded DNA of the Phi X174 virus into the double-stranded replicative form by means of studying which genes were required for the
252:
had reported the isolation of an enzyme that catalyzed the synthesis of RNA. This enzyme was at first hoped to be responsible for the synthesis of RNA in cells, and Ochoa's discovery was honored with a
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441:"The role of deoxyribonucleic acid in ribonucleic acid synthesis. I. The purification and properties of ribonucleic acid polymerase"
226:
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237:. Two years later, he moved back to New York and became an assistant professor of microbiology at the
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963:
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213:, earning a B.A. in chemistry in 1949. He received his Ph.D. in biochemistry in 1953 from
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Operators and
Promoters: The Story of Molecular Biology and its Creators.
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254:
1005:
699:
198:
178:
305:
Louis and Bert
Freeman Foundation Prize for Research in Biochemistry.
1035:
669:
348:"The Discovery and Isolation of RNA Polymerase by Jerard Hurwitz"
125:
519:
1094:
Case
Western Reserve University School of Medicine alumni
1079:
Members of the United States
National Academy of Sciences
373:"JERARD HURWITZ Obituary - New York, NY | New York Times"
234:
194:
1089:
New York
University Grossman School of Medicine faculty
258:
reported the isolation of RNA polymerase activity from
177:(November 20, 1928 – January 24, 2019) was an American
229:
in 1956 and began investigating the incorporation of
189:, and James Bonner. He most recently worked at the
438:
301:, the Institut Pasteur Hazen Lectureship, and the
215:Case Western Reserve University School of Medicine
1099:Washington University School of Medicine faculty
1055:
239:New York University Grossman School of Medicine
225:Hurwitz joined the microbiology department at
505:
241:, where he continued to study RNA synthesis.
439:Furth, J. J.; Hurwitz, J; Anders, M (1962).
512:
498:
456:
415:
227:Washington University School of Medicine
521:Eli Lilly Award in Biological Chemistry
397:
299:Eli Lilly Award in Biological Chemistry
94:Eli Lilly Award in Biological Chemistry
1056:
281:synthesis of the double-stranded DNA.
119:Memorial Sloan Kettering Cancer Center
493:
295:American Academy of Arts and Sciences
379:from the original on 27 January 2019
284:
445:The Journal of Biological Chemistry
365:
13:
111:Washington University in St. Louis
14:
1110:
400:"The discovery of RNA polymerase"
483:University of California Press.
404:Journal of Biological Chemistry
354:from the original on 2013-06-29
329:from the original on 2019-01-26
297:. He has been honored with the
268:Hurwitz along with PhD student
69:Case Western Reserve University
16:American biochemist (1928–2019)
473:
432:
391:
340:
315:
185:in 1960 along with Sam Weiss,
1:
458:10.1016/S0021-9258(19)73796-X
308:
303:New York Academy of Science's
291:National Academy of Sciences
289:Hurwitz was a member of the
204:
7:
132:The metabolism of vitamin b
10:
1115:
1084:Indiana University alumni
527:
220:
191:Sloan-Kettering Institute
150:
146:
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106:
99:
89:
78:
55:
43:
28:
21:
479:Harrison Echols. (2001)
246:Marianne Grunberg-Manago
417:10.1074/jbc.X500006200
724:Charles C. Richardson
193:in New York studying
1074:American biochemists
988:Christopher J. Chang
964:Paul J. Hergenrother
940:Benjamin Cravatt III
838:Jacqueline K. Barton
790:Christopher T. Walsh
946:Dewey G. McCafferty
874:Stuart L. Schreiber
808:Harold M. Weintraub
712:Phillips W. Robbins
398:Hurwitz, J (2005).
115:New York University
970:Scott K. Silverman
952:Linda Hsieh-Wilson
934:Andreas Matouschek
892:Gregory L. Verdine
856:George L. McLendon
658:Harold A. Scheraga
568:Earl A. Evans, Jr.
211:Indiana University
181:who co-discovered
63:Indiana University
1051:
1050:
1024:Bradley Pentelute
994:Matthew D. Disney
802:Roger D. Kornberg
784:Charles R. Cantor
760:James E. Dahlberg
730:Mario R. Capecchi
706:Gerald M. Edelman
694:William P. Jencks
652:Robert A. Alberty
646:William F. Neuman
574:Herbert E. Carter
285:Awards and honors
209:Hurwitz attended
201:and its control.
172:
171:
101:Scientific career
39:November 20, 1928
1106:
898:Alanna Schepartz
862:Peter G. Schultz
832:James E. Rothman
820:David V. Goeddel
796:Phillip A. Sharp
778:Robert G. Roeder
748:Bruce M. Alberts
718:Gordon G. Hammes
634:Nathan O. Kaplan
622:John M. Buchanan
604:Dilworth Woodley
580:Joseph S. Fruton
562:David Rittenberg
538:Harold S. Alcott
532:William M. Allen
514:
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410:(52): 42477–85.
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323:"Jerard Hurwitz"
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261:Escherichia coli
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47:January 24, 2019
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1012:Elizabeth Nolan
928:Kevan M. Shokat
922:Jennifer Doudna
868:William DeGrado
826:Gerald M. Rubin
742:David F. Wilson
682:Frederick Crane
628:David M. Bonner
610:Irving M. Klotz
598:Sidney Colowick
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166:/jerard-hurwitz
162:/research-areas
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56:Alma mater
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850:Michael M. Cox
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772:Joan A. Steitz
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664:Lester J. Reed
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187:Audrey Stevens
183:RNA polymerase
175:Jerard Hurwitz
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83:RNA polymerase
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79:Known for
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51:(aged 90)
45:
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916:Xiaodong Wang
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592:John D. Ferry
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544:Abraham White
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451:(8): 2611–9.
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958:Anna K. Mapp
904:John Kuriyan
880:Peter S. Kim
844:Peter Walter
814:Richard Axel
766:Mark Ptashne
687:
676:James Watson
640:Harvey Itano
556:Eric G. Ball
480:
475:
448:
444:
434:
407:
403:
393:
381:. Retrieved
367:
356:. Retrieved
342:
331:. Retrieved
317:
288:
278:
274:Reed Wickner
267:
265:polymerase.
259:
250:Severo Ochoa
243:
224:
208:
174:
173:
130:
107:Institutions
100:
49:(2019-01-24)
1069:2019 deaths
1064:1928 births
1018:Howard Hang
754:C. Fred Fox
550:George Wald
270:Sue Wickner
255:Nobel prize
136:derivatives
1058:Categories
1006:Minkui Luo
700:Bruce Ames
383:26 January
358:2012-01-13
333:2019-01-27
309:References
199:eukaryotes
179:biochemist
35:1928-11-20
1036:Yimon Aye
670:Paul Berg
244:In 1955,
205:Education
85:discovery
467:13895983
426:16230341
377:Archived
352:Archived
327:Archived
293:and the
279:in vitro
1000:Yi Tang
151:Website
1044:(2021)
1038:(2020)
1032:(2019)
1026:(2018)
1020:(2017)
1014:(2016)
1008:(2015)
1002:(2014)
996:(2013)
990:(2012)
984:(2011)
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221:Career
158:.mskcc
141:(1953)
139:
126:Thesis
90:Awards
233:into
164:/labs
71:(PhD)
463:PMID
422:PMID
385:2019
272:and
248:and
160:.org
65:(BS)
44:Died
29:Born
453:doi
449:237
412:doi
408:280
235:RNA
195:DNA
156:www
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513:e
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33:(
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