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James B. Sumner

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His successful research brought him to full professorship at Cornell in 1929. From 1924 on his laboratory was located on the second floor of the new dairy science building, Stocking Hall (today home to Food Science), at Cornell where he did his Nobel Prize–winning research. In 1937 he succeeded in
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While hunting at age 17, Sumner was accidentally shot by a companion and as a result his left arm had to be amputated just below the elbow. He had been left-handed before the accident, after which he had to learn to do things with his right hand.
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Sumner married Cid Ricketts (born Bertha Louise Ricketts in Brookhaven, Mississippi) when she attended medical school at Cornell. They married on July 10, 1915, and had four children. They were divorced in 1930, but she kept her married name.
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in 1946 for crystallization of enzymes. In 1947 Sumner became the director of Cornell's enzyme chemistry laboratory. Sumner was elected to the
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and then chilling it; the chilled solution produced crystallized urease. He was also able to show by chemical tests that his pure urease was a
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in 1929. It had become clear that Sumner had devised a general crystallization method for enzymes, and also that all enzymes are proteins.
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In 1931 Sumner married Agnes Lundkvist. In 1943 they divorced; later that year he married Mary Beyer, with whom he had two children.
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in pure form; a feat which had never been achieved before. The enzyme he worked with was
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See p.117: "It gave tests for protein and possessed a very high urease activity."
712: 1923: 429:. Cid Ricketts Sumner was murdered by their grandson, John R. Cutler, in 1970. 2231: 2163: 2159: 2079: 2019: 2015: 1892: 1860: 1760: 1736: 1676: 1660: 1628: 1597: 1565: 1361: 1221: 1055: 950: 926: 2485: 2336: 2251: 2239: 2235: 2207: 2183: 2147: 2111: 2087: 2071: 2059: 1967: 1939: 1856: 1768: 1672: 1517: 1509: 1453: 1445: 1393: 1373: 1322: 1146: 1138: 1002: 942: 505: 160: 2047: 2003: 1987: 1935: 1884: 1828: 1756: 1728: 1712: 1648: 1533: 1525: 1477: 1473: 1465: 1233: 1158: 974: 910: 425: 386: 247: 769: 132: 2283: 2135: 2119: 2099: 2095: 1872: 1844: 1840: 1804: 1772: 1724: 1692: 1225: 1213: 1193: 1079: 1040: 982: 535:
Sumner died at age 67 of cancer in Buffalo, New York on August 12, 1955.
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had obtained other crystalline enzymes by similar methods, starting with
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It was in 1917 at Cornell where Sumner began his research into isolating
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Both Sumner and Northrop, along with Wendell M Stanley, shared the
469: 682:"The Nobel Prize in Chemistry 1946 James B. Sumner - Biographical" 461: 457: 453: 320: 219: 213: 497: 481: 445: 441: 304: 209: 881: 603:"The Nobel Prize in Chemistry 1946 James B. Sumner - Facts" 397:. He then worked as assistant professor of biochemistry at 2537:
Members of the United States National Academy of Sciences
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went on to become an author, writing books that included
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Biographical Memoirs of the National Academy of Sciences
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in 1910 where he was acquainted with prominent chemists
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Fellows of the American Academy of Arts and Sciences
784: 49:. Unsourced material may be challenged and removed. 319:. He was also the first to prove that enzymes are 523:in 1948. In 1949, he was elected a Fellow of the 2483: 566:Harris, Ruth R.; Nirenberg, Marshall W. (1995). 778:including the Nobel Lecture, December 12, 1946 2281: 729:The chemical nature of enzymes (Nobel lecture) 2267: 867: 468:isolating and crystallizing a second enzyme, 307:can be crystallized, for which he shared the 393:and obtained his Ph.D. degree in 1914 with 2274: 2260: 874: 860: 773: 676: 674: 672: 131: 810: 648:. Infobase Publishing. pp. 354–355. 559: 331:Sumner was born on November 19, 1887, in 109:Learn how and when to remove this message 747:. American Academy of Arts and Sciences 742:"Book of Members, 1780–2010: Chapter S" 669: 637: 635: 633: 631: 629: 627: 625: 623: 2484: 2255: 855: 641: 525:American Academy of Arts and Sciences 504:. Also that year, he was awarded the 620: 487: 47:adding citations to reliable sources 18: 734: 13: 763: 218:First to show that an enzyme is a 14: 2548: 2527:People from Canton, Massachusetts 2507:20th-century American biochemists 833: 719:website. Retrieved July 22, 2012. 717:Mississippi Artists and Musicians 1104: 820:"Sumner, James B. (1887–1955)". 642:Carey, Charles W. (2014-05-14). 413:, which was made into the movie 23: 380:Worcester Polytechnic Institute 34:needs additional citations for 841:The Chemical Nature of Enzymes 780:The Chemical Nature of Enzymes 722: 699: 595: 545: 1: 2522:Harvard Medical School alumni 575:National Institutes of Health 538: 2517:Nobel laureates in Chemistry 785:Alexander L. Dounce (1955). 577:. p. 41. Archived from 521:National Academy of Sciences 496:and he spent five months in 326: 7: 847:Speech at the Nobel banquet 435: 10: 2553: 2512:Cornell University faculty 385:In 1912, he went to study 2409: 2390: 2371: 2346: 2322: 2291: 1910: 1611: 1352: 1113: 1102: 893: 448:, which he isolated from 423:, which became the movie 290: 280: 268: 253: 243: 236: 225: 204: 194: 186: 167: 142: 130: 123: 2502:American Nobel laureates 2313:Wendell Meredith Stanley 2028:Venkatraman Ramakrishnan 1307:Wendell Meredith Stanley 887:Nobel Prize in Chemistry 839:Sumner's Nobel Lecture 530: 492:In 1937, he was given a 376:Sackville, New Brunswick 372:Mount Allison University 317:Wendell Meredith Stanley 309:Nobel Prize in Chemistry 258:Mount Allison University 230:Nobel Prize in Chemistry 2381:Percy Williams Bridgman 787:"Prof. James B. Sumner" 568:"The Harris Interviews" 500:working with Professor 297:James Batcheller Sumner 2415:Nobel Prize recipients 2392:Physiology or Medicine 2192:Emmanuelle Charpentier 2180:M. Stanley Whittingham 1151:Hans von Euler-Chelpin 416:Tammy and the Bachelor 399:Cornell Medical School 391:Harvard Medical School 368:Charles Loring Jackson 342:Sumner graduated from 2400:Hermann Joseph Muller 1562:Christian B. Anfinsen 1202:FrĂ©dĂ©ric Joliot-Curie 706:"Cid Ricketts Sumner" 494:Guggenheim Fellowship 478:Rockefeller Institute 333:Canton, Massachusetts 303:. He discovered that 157:Canton, Massachusetts 2307:John Howard Northrop 2224:Karl Barry Sharpless 1721:Dudley R. Herschbach 1546:Luis Federico Leloir 474:John Howard Northrop 313:John Howard Northrop 208:First to isolate an 43:improve this article 2216:Carolyn R. Bertozzi 2128:Jean-Pierre Sauvage 1865:Jens Christian Skou 1833:F. Sherwood Rowland 1745:Charles J. Pedersen 1709:Herbert A. Hauptman 1402:Vincent du Vigneaud 1019:Richard Willstätter 903:Jacobus van 't Hoff 803:1955Natur.176..859D 645:American Scientists 407:Cid Ricketts Sumner 364:James Bryant Conant 2356:Emily Greene Balch 2176:John B. Goodenough 2104:William E. Moerner 1984:Richard R. Schrock 1956:Roderick MacKinnon 1928:K. Barry Sharpless 1753:Johann Deisenhofer 1582:Geoffrey Wilkinson 1578:Ernst Otto Fischer 1502:Robert S. Mulliken 1438:Jaroslav HeyrovskĂ˝ 1386:Hermann Staudinger 1206:Irène Joliot-Curie 772:on Nobelprize.org 711:2012-09-20 at the 411:Tammy Tell Me True 356:Farrington Daniels 344:Harvard University 263:Cornell University 199:Harvard University 2479: 2478: 2249: 2248: 2232:Moungi G. Bawendi 2152:Richard Henderson 1996:Roger D. Kornberg 1964:Aaron Ciechanover 1797:Rudolph A. Marcus 1701:Robert Merrifield 1637:Peter D. Mitchell 1410:Cyril Hinshelwood 1171:Friedrich Bergius 1095:Richard Zsigmondy 1011:Theodore Richards 959:Ernest Rutherford 488:Honors and awards 360:Frank C. Whitmore 348:bachelor's degree 294: 293: 281:Doctoral students 238:Scientific career 179:Buffalo, New York 153:November 19, 1887 119: 118: 111: 93: 58:"James B. Sumner" 2544: 2417: 2276: 2269: 2262: 2253: 2252: 2242: 2240:Alexei I. Ekimov 2226: 2220:Morten P. Meldal 2210: 2198: 2186: 2170: 2154: 2144:Jacques Dubochet 2138: 2122: 2106: 2090: 2074: 2068:Robert Lefkowitz 2062: 2054: 2038: 2032:Thomas A. Steitz 2022: 2006: 1998: 1990: 1980:Robert H. Grubbs 1974: 1958: 1946: 1930: 1903: 1901:Hideki Shirakawa 1887: 1879: 1867: 1851: 1835: 1819: 1811: 1799: 1791: 1789:Richard R. Ernst 1783: 1775: 1763: 1747: 1731: 1715: 1703: 1695: 1687: 1679: 1667: 1665:Frederick Sanger 1651: 1645:Herbert C. Brown 1639: 1631: 1623: 1621:William Lipscomb 1604: 1592: 1584: 1572: 1556: 1554:Gerhard Herzberg 1548: 1540: 1528: 1520: 1504: 1496: 1488: 1480: 1468: 1456: 1448: 1440: 1432: 1430:Frederick Sanger 1424: 1416: 1414:Nikolay Semyonov 1404: 1396: 1388: 1380: 1368: 1366:Glenn T. 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Sumner 766: 764:Further reading 761: 760: 750: 748: 744: 740: 739: 735: 727: 723: 713:Wayback Machine 704: 700: 690: 688: 680: 679: 670: 660: 658: 656: 640: 621: 611: 609: 601: 600: 596: 587: 585: 581: 570: 564: 560: 551: 550: 546: 541: 533: 490: 438: 401:in Ithaca, NY. 329: 261: 217: 195:Alma mater 182: 176: 172: 171:August 12, 1955 163: 154: 148: 146: 138: 126: 125:James B. Sumner 115: 104: 98: 95: 52: 50: 40: 28: 17: 12: 11: 5: 2550: 2540: 2539: 2534: 2529: 2524: 2519: 2514: 2509: 2504: 2499: 2494: 2477: 2476: 2474: 2473: 2468: 2463: 2458: 2453: 2448: 2443: 2438: 2433: 2428: 2423: 2418: 2410: 2407: 2406: 2404: 2403: 2396: 2394: 2388: 2387: 2385: 2384: 2377: 2375: 2369: 2368: 2366: 2365: 2359: 2352: 2350: 2344: 2343: 2341: 2340: 2333: 2331: 2320: 2319: 2317: 2316: 2310: 2304: 2297: 2295: 2289: 2288: 2279: 2278: 2271: 2264: 2256: 2247: 2246: 2244: 2243: 2227: 2211: 2199: 2187: 2171: 2164:Gregory Winter 2160:Frances Arnold 2155: 2139: 2123: 2107: 2091: 2084:Michael Levitt 2080:Martin Karplus 2075: 2063: 2055: 2039: 2023: 2020:Roger Y. Tsien 2016:Martin Chalfie 2007: 1999: 1991: 1975: 1959: 1947: 1931: 1914: 1912: 1908: 1907: 1905: 1904: 1893:Alan J. Heeger 1888: 1880: 1868: 1861:John E. Walker 1852: 1836: 1820: 1812: 1800: 1792: 1784: 1776: 1764: 1761:Hartmut Michel 1748: 1737:Donald J. 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Fenn 1924:Ryoji Noyori 1911:2001–present 1885:Ahmed Zewail 1845:Harold Kroto 1829:Mario Molina 1757:Robert Huber 1729:John Polanyi 1713:Jerome Karle 1649:Georg Wittig 1534:Derek Barton 1526:Lars Onsager 1478:Giulio Natta 1474:Karl Ziegler 1466:John Kendrew 1298: 1234:Richard Kuhn 1159:Hans Fischer 975:Otto Wallach 911:Emil Fischer 825: 821: 794: 790: 779: 749:. Retrieved 736: 724: 716: 701: 689:. Retrieved 685: 659:. Retrieved 644: 610:. Retrieved 606: 597: 586:. Retrieved 579:the original 561: 547: 534: 514: 491: 466: 454:crystallized 439: 431: 424: 420: 414: 410: 403: 387:biochemistry 384: 341: 337: 330: 296: 295: 254:Institutions 248:Biochemistry 237: 214:crystallized 173:(1955-08-12) 105: 96: 86: 79: 72: 65: 53: 41:Please help 36:verification 33: 2497:1955 deaths 2492:1887 births 2284:Nobel Prize 2136:Ben Feringa 2120:Aziz Sancar 2100:Stefan Hell 2096:Eric Betzig 1873:Walter Kohn 1841:Robert Curl 1817:George Olah 1805:Kary Mullis 1781:Elias Corey 1773:Thomas Cech 1725:Yuan T. Lee 1693:Henry Taube 1226:Paul Karrer 1214:Peter Debye 1194:Harold Urey 1080:Fritz Pregl 1041:Fritz Haber 983:Marie Curie 517:Nobel Prize 352:Roger Adams 187:Nationality 2486:Categories 2324:Literature 1972:Irwin Rose 1952:Peter Agre 1877:John Pople 1685:Aaron Klug 1590:Paul Flory 1538:Odd Hassel 1462:Max Perutz 1343:Kurt Alder 1339:Otto Diels 1167:Carl Bosch 691:4 November 661:17 January 612:4 November 588:2012-07-23 539:References 450:jack beans 395:Otto Folin 301:biochemist 275:Otto Folin 149:1887-11-19 69:newspapers 2362:John Mott 2293:Chemistry 2286:laureates 1657:Paul Berg 1612:1976–2000 1353:1951–1975 1283:Otto Hahn 1114:1926–1950 894:1901–1925 883:Laureates 845:Sumner's 510:Stockholm 327:Biography 751:14 April 709:Archived 470:catalase 436:Research 321:proteins 190:American 2373:Physics 885:of the 799:Bibcode 476:of the 462:protein 458:acetone 442:enzymes 421:Quality 346:with a 305:enzymes 220:protein 83:scholar 2230:2023: 2214:2022: 2202:2021: 2190:2020: 2174:2019: 2158:2018: 2142:2017: 2126:2016: 2110:2015: 2094:2014: 2078:2013: 2066:2012: 2058:2011: 2042:2010: 2026:2009: 2010:2008: 2002:2007: 1994:2006: 1978:2005: 1962:2004: 1950:2003: 1934:2002: 1918:2001: 1891:2000: 1883:1999: 1871:1998: 1855:1997: 1839:1996: 1823:1995: 1815:1994: 1803:1993: 1795:1992: 1787:1991: 1779:1990: 1767:1989: 1751:1988: 1735:1987: 1719:1986: 1707:1985: 1699:1984: 1691:1983: 1683:1982: 1671:1981: 1655:1980: 1643:1979: 1635:1978: 1627:1977: 1619:1976: 1596:1975: 1588:1974: 1576:1973: 1560:1972: 1552:1971: 1544:1970: 1532:1969: 1524:1968: 1508:1967: 1500:1966: 1492:1965: 1484:1964: 1472:1963: 1460:1962: 1452:1961: 1444:1960: 1436:1959: 1428:1958: 1420:1957: 1408:1956: 1400:1955: 1392:1954: 1384:1953: 1372:1952: 1360:1951: 1337:1950: 1329:1949: 1321:1948: 1313:1947: 1297:1946: 1289:1945: 1281:1944: 1273:1943: 1240:1939: 1232:1938: 1220:1937: 1212:1936: 1200:1935: 1192:1934: 1177:1932: 1165:1931: 1157:1930: 1145:1929: 1137:1928: 1129:1927: 1121:1926: 1093:1925: 1078:1923: 1070:1922: 1062:1921: 1054:1920: 1039:1918: 1017:1915: 1009:1914: 1001:1913: 989:1912: 981:1911: 973:1910: 965:1909: 957:1908: 949:1907: 941:1906: 933:1905: 925:1904: 917:1903: 909:1902: 901:1901: 791:Nature 652:  498:Sweden 482:pepsin 446:urease 419:, and 244:Fields 232:(1946) 226:Awards 210:enzyme 85:  78:  71:  64:  56:  2446:1946 2348:Peace 2282:1946 745:(PDF) 571:(PDF) 531:Death 426:Pinky 181:, USA 90:JSTOR 76:books 2471:1951 2466:1950 2461:1949 2456:1948 2451:1947 2441:1945 2436:1944 2431:1943 2426:1942 2421:1941 2328:1946 1267:1942 1260:1941 1253:1940 1186:1933 1087:1924 1048:1919 1033:1917 1026:1916 753:2011 693:2020 663:2016 650:ISBN 614:2020 366:and 315:and 216:form 168:Died 143:Born 62:news 807:doi 795:176 508:in 389:in 374:in 212:in 161:USA 45:by 2488:: 2238:/ 2234:/ 2222:/ 2218:/ 2206:/ 2194:/ 2182:/ 2178:/ 2166:/ 2162:/ 2150:/ 2146:/ 2134:/ 2130:/ 2118:/ 2114:/ 2102:/ 2098:/ 2086:/ 2082:/ 2070:/ 2050:/ 2046:/ 2034:/ 2030:/ 2018:/ 2014:/ 1986:/ 1982:/ 1970:/ 1966:/ 1954:/ 1942:/ 1938:/ 1926:/ 1922:/ 1899:/ 1895:/ 1875:/ 1863:/ 1859:/ 1847:/ 1843:/ 1831:/ 1827:/ 1807:/ 1771:/ 1759:/ 1755:/ 1743:/ 1739:/ 1727:/ 1723:/ 1711:/ 1675:/ 1663:/ 1659:/ 1647:/ 1600:/ 1580:/ 1568:/ 1564:/ 1536:/ 1516:/ 1512:/ 1476:/ 1464:/ 1412:/ 1376:/ 1364:/ 1341:/ 1305:/ 1301:/ 1244:/ 1224:/ 1204:/ 1169:/ 1149:/ 993:/ 826:31 824:. 805:. 793:. 789:. 715:, 684:. 671:^ 622:^ 605:. 573:. 527:. 512:. 382:. 362:, 358:, 354:, 335:. 323:. 159:, 2330:) 2326:( 2275:e 2268:t 2261:v 875:e 868:t 861:v 828:. 815:. 809:: 801:: 755:. 695:. 665:. 616:. 591:. 555:. 260:, 151:) 147:( 112:) 106:( 101:) 97:( 87:· 80:· 73:· 66:· 39:.

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"James B. Sumner"
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Canton, Massachusetts
USA
Buffalo, New York
Harvard University
enzyme
crystallized
protein
Nobel Prize in Chemistry
Biochemistry
Mount Allison University
Cornell University
Doctoral advisor
Otto Folin
Alexander Dounce
biochemist
enzymes
Nobel Prize in Chemistry
John Howard Northrop

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