161:, Japan (B.S. 1968, Ph.D. 1973). Before coming to the U.S. as an associate professor at the State University of New York at Stony Brook in 1983, he worked at the Sagami Institute of Chemical Research in Japan, first as a research fellow and later as a senior research fellow and group leader of the organometallic chemistry and organic synthesis research group. At Stony Brook, he quickly climbed the ranks: he was promoted to professor in 1984, leading professor in 1991, and university distinguished professor in 1995. He served as department chair from 1997 to 2003 and has been serving as the founding director of the Institute of Chemical Biology and Drug Discovery (ICB&DD) since 2003, as well as the president of the Stony Brook Chapter of the
28:
218:-acylfluoroamino acids via hydroformylation-amidocarbonylation of fluoro-olefins, synthesis of a-trifluoromethylacrylic acid via carboxylation, novel ureidocarbonylation, synthesis of optically pure fluoroamino acids via enzymatic kinetic resolution, etc. It is noteworthy that Ojima's synthesis of trifluoromethyluracil from 2-bromotrifluoropropene became an industrial process by Japan Halon (then, Tosoh F-Tech). Furthermore, this process was successfully applied to the commercial synthesis of
145:). He has been widely recognized for his seminal contributions to a range of chemical research at the multifaceted interfaces of chemical synthesis and life sciences. As rare accomplishments, he has received four National Awards from the American Chemical Society in four different fields of research. He is also serving as the director of the Institute of Chemical Biology and Drug Discovery (ICB&DD), as well as the president of the Stony Brook Chapter of the National Academy of Inventors.
285:
performed in his laboratory have led to the development of numerous highly potent novel second- and third-generation taxoids. The third-generation taxoids showed virtually no difference in potency against drug-resistant and drug-sensitive cell lines. Some of the next-generation taxoids also exhibited
202:
catalyzed reactions and investigations into their mechanisms, which includes hydrosilylation, silylformylation, silylcarbocyclizations (SiCaCs, SiCaB, SiCaT), higher order (carbonylative) cycloadditions, hydroformylation, hydrocarbonylations, amidocarbonylations, cyclohydrocarbonylations, and
193:
and organic synthesis. He received a 25th CSJ Award for Young
Investigator for his research on "Highly selective syntheses by means of organosilicon compounds – transition metal complex systems" from the Chemical Society of Japan in 1976. Through the 1970-1980s, he established himself as an
222:(trifluorothymidine), an antiherpes antiviral drug, primarily used on the eye topically, such as "Viroptic" by Tokyo Yuki Gosei Kogyo in early 1990s. His pioneering work on optically pure fluoroamino acids and their use in medicinally active compounds, such as
337:
As of
January 2024, he has published >500 papers and reviews in leading journals, >100 issued patents, edited nine books, and given >135 plenary and invited lectures in international meetings. SciFinder lists >1,000 publications to his credit.
198:" (Wiley-VCH) in 1993, and also published the second (2000) and third (2010) editions. This book collectively became a very popular reference book with >4,100 citations. He was a prolific researcher in the development of new synthetic methods based on
298:
and computational analyses, identification of unique characteristics of the next-generation taxoids in cancer cell biology and their mechanism of action, and efficacious tumor-targeted drug delivery of highly potent next-generation taxoids.
273:), one of the most widely used anticancer drug for chemotherapy, through the Ojima-Holton coupling, as well as for the medicinal chemistry and development of new-generation taxoid anticancer agents. One of his second-generation taxoids, "
1185:
965:
Lazzarini, Cristina; Haranahalli, Krupanandan; Rieger, Robert; Ananthula, Hari
Krishna; Desai, Pankaj B.; Ashbaugh, Alan; Linke, Michael J.; Cushion, Melanie T.; Ruzsicska, Bela (2018-03-05).
334:
are integrated in close collaborations with structural biologists, computer biologists, cell biologists, oncologists, microbiologist, pharmacologists, anesthesiologists, toxicologists, etc.
242:(Wiley-Blackwell, > 1,700 citations) in 2009, featuring the basic principles and exemplary applications of fluorine incorporation to biologically relevant compounds and systems.
656:
Yamazaki, Takashi; Taguchi, Takeo; Ojima, Iwao (2009-04-03), Ojima, Iwao (ed.), "Unique
Properties of Fluorine and their Relevance to Medicinal Chemistry and Chemical Biology",
873:
Ojima, Iwao (2008-04-15). "ChemInform
Abstract: Guided Molecular Missiles for Tumor-Targeting Chemotherapy-Case Studies Using the Second-Generation Taxoids as Warheads".
210:
by exploring the interface of fluorine chemistry and organometallic chemistry/catalysis. His notable achievements include the development of processes for the highly
302:
Currently, Ojima's research program is focused on the drug discovery and development of next-generation anticancer agents and their tumor-targeted drug delivery,
177:, BIOCIS, Châtenay-Malabry, France (1997). As an extracurricular activity, he has been serving as the president of the Japan Center at Stony Brook since 2004.
731:
Ojima, Iwao; Delaloge, Francette (1997). "Asymmetric synthesis of building-blocks for peptides and peptidomimetics by means of the β-lactam synthon method".
362:
203:
enantioselective processes such as hydrosilylation, hydrogenation, hydroformylation, Michael addition, allylic alkylation/amination/etherification, etc.
1284:
1373:
1022:
Yan, Su; Elmes, Matthew W.; Tong, Simon; Hu, Kongzhen; Awwa, Monaf; Teng, Gary Y.H.; Jing, Yunrong; Freitag, Matthew; Gan, Qianwen (June 2018).
1079:
830:
Ojima, Iwao (2008). "Guided
Molecular Missiles for Tumor-Targeting Chemotherapy—Case Studies Using the Second-Generation Taxoids as Warheads".
245:
One of his renowned achievements is the development of the "β-Lactam
Synthon Method", which has been applied to the synthesis of α- and β-
1255:
294:-stabilizing anticancer agents, identification of the paclitaxel binding site and its bioactive conformation in the β-tubulin based on
355:
1348:
73:
ACS Award for
Creative Work in Fluorine Chemistry (2013) ACS E. B. Hershberg Award (2001) Chemical Society of Japan Award (1998)
1209:
1171:
1024:"SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins"
1353:
282:
431:
277:", developed from 14-hydroxy-10-deacetylbaccatin III, and licensed to Indena, SpA, Italy, has advanced to the Phase II
673:
549:
573:
166:
189:
of phosphine-Rh complexes, its development as new synthetic processes, as well as their applications to catalytic
238:), brought medicinal and biomedical applications to the scope of fluorine chemistry community. He edited a book,
908:
Kumar, Kunal; Awasthi, Divya; Berger, William T; Tonge, Peter J; Slayden, Richard A; Ojima, Iwao (August 2010).
170:
1368:
531:
395:
162:
1233:
375:
348:
138:
137:(born June 5, 1945, in Japan) is a Japanese-American chemist and university distinguished professor at the
76:
1363:
1358:
190:
368:
314:
agents, etc. In his research, all relevant chemistry and biological tools, including computer-aided
174:
388:
207:
775:"Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery"
1343:
601:"Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology"
295:
278:
142:
102:
402:
323:
186:
68:
1263:
1338:
459:"Stony Brook University Welcome to the Institute of Chemical Biology & Drug Discovery"
261:
and taxoids. This method has been successfully applied for the practical synthesis of the
8:
1147:
158:
56:
1056:
1023:
999:
966:
942:
909:
807:
774:
679:
633:
600:
555:
319:
1103:
1061:
1043:
1004:
986:
967:"Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids"
947:
929:
890:
855:
847:
812:
794:
748:
713:
669:
638:
620:
545:
506:
683:
559:
1051:
1035:
994:
978:
937:
921:
882:
839:
802:
786:
740:
705:
661:
628:
612:
537:
482:
327:
211:
199:
27:
1186:"E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances"
1039:
790:
311:
286:
excellent potency against cancer stem cells. Other highlights include his common
254:
665:
1332:
1308:
1047:
990:
933:
894:
851:
798:
752:
717:
624:
287:
117:
458:
1065:
1008:
951:
886:
859:
816:
696:
Ojima, Iwao (1995). "Recent
Advances in the .beta.-Lactam Synthon Method".
642:
331:
262:
250:
219:
541:
194:
authoritative scholar in catalytic asymmetric synthesis, editing a book, "
982:
744:
315:
291:
910:"Discovery of anti-TB agents that target the cell-division protein FtsZ"
709:
1123:
925:
307:
303:
266:
246:
235:
231:
223:
843:
616:
274:
227:
169:, Lyon, France (1989), the University of Tokyo, Tokyo, Japan (1996),
773:
Ojima, Iwao; Wang, Xin; Jing, Yunrong; Wang, Changwei (2018-02-22).
964:
154:
258:
270:
185:
In Ojima's early research career, he was mainly engaged in
907:
384:
Fellow, American
Chemical Society "ACS Fellow" (2010).
265:, a key intermediate for the commercial production of
240:"Fluorine in Medicinal Chemistry and Chemical Biology"
483:"Home | Chapter of the National Academy of Inventors"
658:
Fluorine in Medicinal Chemistry and Chemical Biology
655:
1128:
American Association for the Advancement of Science
363:
American Association for the Advancement of Science
165:from 2015. He has been a visiting professor at the
408:Fellow/Member European Academy of Sciences (2020).
214:hydroformylations of fluoro-olefins, synthesis of
772:
1330:
536:. Hoboken, NJ, USA: John Wiley & Sons, Inc.
1104:"John Simon Guggenheim Foundation | Iwao Ojima"
1256:"Fellows List - National Academy of Inventors"
1021:
206:Since the late 1970s, Ojima began his work in
730:
660:, John Wiley & Sons, Ltd, pp. 1–46,
1309:"European Academy of Sciences - Iwao Ojima"
26:
1055:
998:
941:
806:
632:
356:John Simon Guggenheim Memorial Foundation
1374:Japanese emigrants to the United States
1028:European Journal of Medicinal Chemistry
1331:
381:ACS Emanuel B. Hershberg Award (2001).
971:Antimicrobial Agents and Chemotherapy
872:
829:
768:
766:
764:
762:
695:
598:
529:
157:, Japan, in 1945 and educated at the
594:
592:
590:
507:"Home | Japan Center at Stony Brook"
453:
451:
426:
424:
422:
341:
13:
1277:
866:
759:
14:
1385:
1234:"ACS 2013 National Award Winners"
587:
574:"Publications list of Iwao Ojima"
448:
419:
180:
1285:"2019 National Award Recipients"
605:The Journal of Organic Chemistry
167:Université Claude Bernard Lyon I
1301:
1248:
1226:
1202:
1178:
1164:
1140:
1116:
1096:
1080:"Arthur C. Cope Scholar Awards"
1072:
1015:
958:
901:
823:
724:
530:Ojima, Iwao, ed. (2010-02-10).
387:ACS Award for Creative Work in
94:Organic and Medicinal Chemistry
1349:Stony Brook University faculty
689:
649:
566:
533:Catalytic Asymmetric Synthesis
523:
499:
475:
196:Catalytic Asymmetric Synthesis
171:the Scripps Research Institute
1:
1238:Chemical and Engineering News
832:Accounts of Chemical Research
698:Accounts of Chemical Research
412:
396:National Academy of Inventors
163:National Academy of Inventors
1244:(34): 53–54. 20 August 2012.
1040:10.1016/j.ejmech.2018.04.050
791:10.1021/acs.jnatprod.7b01012
376:New York Academy of Sciences
349:Arthur C. Cope Scholar Award
148:
139:State University of New York
77:Arthur C. Cope Scholar Award
7:
779:Journal of Natural Products
173:, La Jolla, CA (1997), and
10:
1390:
1354:University of Tokyo alumni
914:Future Medicinal Chemistry
599:Ojima, Iwao (2013-07-05).
1289:American Chemical Society
1214:American Chemical Society
1190:American Chemical Society
1084:American Chemical Society
666:10.1002/9781444312096.ch1
369:Chemical Society of Japan
112:
108:
98:
90:
83:
63:
52:
34:
25:
18:
432:"Iwao Ojima | Chemistry"
208:organofluorine chemistry
1260:academyofinventors.org
887:10.1002/chin.200816271
581:Stony Brook University
296:photoaffinity labeling
175:Université de Paris XI
143:Stony Brook University
103:Stony Brook University
542:10.1002/9780470584248
324:computational biology
279:human clinical trials
187:homogeneous catalysis
69:Ernest Guenther Award
1369:People from Yokohama
983:10.1128/aac.00156-18
745:10.1039/CS9972600377
403:Enest Guenther Award
398:"NAI Fellow" (2014).
191:asymmetric synthesis
710:10.1021/ar00057a004
159:University of Tokyo
59:(B.S., M.S., Ph.D.)
57:University of Tokyo
1210:"2010 ACS Fellows"
926:10.4155/fmc.10.220
511:www.stonybrook.edu
487:www.stonybrook.edu
463:www.stonybrook.edu
436:www.stonybrook.edu
389:Fluorine Chemistry
320:chemical synthesis
153:Ojima was born in
1364:Japanese chemists
1359:American chemists
1124:"Elected Fellows"
844:10.1021/ar700093f
617:10.1021/jo400301u
611:(13): 6358–6383.
342:Awards and honors
132:
131:
85:Scientific career
1381:
1323:
1322:
1320:
1319:
1305:
1299:
1298:
1296:
1295:
1281:
1275:
1274:
1272:
1271:
1262:. Archived from
1252:
1246:
1245:
1230:
1224:
1223:
1221:
1220:
1206:
1200:
1199:
1197:
1196:
1182:
1176:
1175:
1168:
1162:
1161:
1159:
1158:
1144:
1138:
1137:
1135:
1134:
1120:
1114:
1113:
1111:
1110:
1100:
1094:
1093:
1091:
1090:
1076:
1070:
1069:
1059:
1019:
1013:
1012:
1002:
962:
956:
955:
945:
920:(8): 1305–1323.
905:
899:
898:
870:
864:
863:
827:
821:
820:
810:
770:
757:
756:
728:
722:
721:
693:
687:
686:
653:
647:
646:
636:
596:
585:
584:
578:
570:
564:
563:
527:
521:
520:
518:
517:
503:
497:
496:
494:
493:
479:
473:
472:
470:
469:
455:
446:
445:
443:
442:
428:
328:chemical biology
281:. The extensive
200:transition-metal
141:at Stony Brook (
128:
125:
123:
121:
119:
48:
44:
42:
30:
16:
15:
1389:
1388:
1384:
1383:
1382:
1380:
1379:
1378:
1329:
1328:
1327:
1326:
1317:
1315:
1307:
1306:
1302:
1293:
1291:
1283:
1282:
1278:
1269:
1267:
1254:
1253:
1249:
1232:
1231:
1227:
1218:
1216:
1208:
1207:
1203:
1194:
1192:
1184:
1183:
1179:
1170:
1169:
1165:
1156:
1154:
1146:
1145:
1141:
1132:
1130:
1122:
1121:
1117:
1108:
1106:
1102:
1101:
1097:
1088:
1086:
1078:
1077:
1073:
1020:
1016:
963:
959:
906:
902:
871:
867:
828:
824:
771:
760:
729:
725:
694:
690:
676:
654:
650:
597:
588:
576:
572:
571:
567:
552:
528:
524:
515:
513:
505:
504:
500:
491:
489:
481:
480:
476:
467:
465:
457:
456:
449:
440:
438:
430:
429:
420:
415:
344:
312:antinociceptive
255:peptidomimetics
183:
151:
116:
46:
40:
38:
21:
12:
11:
5:
1387:
1377:
1376:
1371:
1366:
1361:
1356:
1351:
1346:
1341:
1325:
1324:
1313:www.eurasc.org
1300:
1276:
1247:
1225:
1201:
1177:
1172:"www.nyas.org"
1163:
1139:
1115:
1095:
1071:
1014:
957:
900:
865:
838:(1): 108–119.
822:
785:(3): 703–721.
758:
739:(5): 377–386.
733:Chem. Soc. Rev
723:
704:(9): 383–389.
688:
674:
648:
586:
565:
550:
522:
498:
474:
447:
417:
416:
414:
411:
410:
409:
406:
399:
392:
385:
382:
379:
372:
366:
359:
352:
343:
340:
212:regioselective
182:
181:Research areas
179:
150:
147:
130:
129:
114:
110:
109:
106:
105:
100:
96:
95:
92:
88:
87:
81:
80:
65:
61:
60:
54:
50:
49:
36:
32:
31:
23:
22:
19:
9:
6:
4:
3:
2:
1386:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1344:Living people
1342:
1340:
1337:
1336:
1334:
1314:
1310:
1304:
1290:
1286:
1280:
1266:on 2019-06-21
1265:
1261:
1257:
1251:
1243:
1239:
1235:
1229:
1215:
1211:
1205:
1191:
1187:
1181:
1173:
1167:
1153:
1149:
1143:
1129:
1125:
1119:
1105:
1099:
1085:
1081:
1075:
1067:
1063:
1058:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1018:
1010:
1006:
1001:
996:
992:
988:
984:
980:
976:
972:
968:
961:
953:
949:
944:
939:
935:
931:
927:
923:
919:
915:
911:
904:
896:
892:
888:
884:
880:
876:
869:
861:
857:
853:
849:
845:
841:
837:
833:
826:
818:
814:
809:
804:
800:
796:
792:
788:
784:
780:
776:
769:
767:
765:
763:
754:
750:
746:
742:
738:
734:
727:
719:
715:
711:
707:
703:
699:
692:
685:
681:
677:
675:9781444312096
671:
667:
663:
659:
652:
644:
640:
635:
630:
626:
622:
618:
614:
610:
606:
602:
595:
593:
591:
582:
575:
569:
561:
557:
553:
551:9780470584248
547:
543:
539:
535:
534:
526:
512:
508:
502:
488:
484:
478:
464:
460:
454:
452:
437:
433:
427:
425:
423:
418:
407:
404:
400:
397:
393:
390:
386:
383:
380:
377:
373:
371:Award (1998).
370:
367:
364:
360:
357:
353:
350:
346:
345:
339:
335:
333:
329:
325:
321:
317:
313:
309:
305:
304:antibacterial
300:
297:
293:
290:proposal for
289:
288:pharmacophore
284:
280:
276:
272:
268:
264:
260:
256:
252:
251:oligopeptides
248:
243:
241:
237:
233:
229:
225:
221:
217:
213:
209:
204:
201:
197:
192:
188:
178:
176:
172:
168:
164:
160:
156:
146:
144:
140:
136:
127:
115:
111:
107:
104:
101:
97:
93:
89:
86:
82:
78:
74:
70:
66:
62:
58:
55:
51:
47:(age 79)
37:
33:
29:
24:
17:
1316:. Retrieved
1312:
1303:
1292:. Retrieved
1288:
1279:
1268:. Retrieved
1264:the original
1259:
1250:
1241:
1237:
1228:
1217:. Retrieved
1213:
1204:
1193:. Retrieved
1189:
1180:
1166:
1155:. Retrieved
1151:
1148:"CSJ Awards"
1142:
1131:. Retrieved
1127:
1118:
1107:. Retrieved
1098:
1087:. Retrieved
1083:
1074:
1031:
1027:
1017:
974:
970:
960:
917:
913:
903:
878:
874:
868:
835:
831:
825:
782:
778:
736:
732:
726:
701:
697:
691:
657:
651:
608:
604:
580:
568:
532:
525:
514:. Retrieved
510:
501:
490:. Retrieved
486:
477:
466:. Retrieved
462:
439:. Retrieved
435:
336:
332:cell biology
310:agents, and
301:
263:Ojima lactam
244:
239:
220:trifluridine
215:
205:
195:
184:
152:
134:
133:
99:Institutions
84:
72:
45:June 5, 1945
1339:1945 births
1034:: 233–252.
316:drug design
292:microtubule
283:SAR studies
247:amino acids
1333:Categories
1318:2021-01-26
1294:2019-05-06
1270:2019-05-23
1219:2019-05-23
1195:2019-05-17
1157:2019-05-17
1152:www.csj.jp
1133:2019-05-22
1109:2019-05-22
1089:2019-05-17
875:ChemInform
516:2019-06-04
492:2019-06-04
468:2019-06-04
441:2019-06-04
413:References
308:antifungal
267:paclitaxel
236:paclitaxel
224:enkephalin
135:Iwao Ojima
118:stonybrook
41:1945-06-05
20:Iwao Ojima
1048:0223-5234
991:0066-4804
934:1756-8919
895:0931-7597
852:0001-4842
799:0163-3864
753:0306-0012
718:0001-4842
625:0022-3263
275:ortataxel
228:captopril
149:Biography
53:Education
1066:29803996
1009:29507066
952:21339840
860:17663526
817:29468872
684:93933024
643:23614876
560:93318061
394:Fellow,
374:Fellow,
361:Fellow,
354:Fellow,
306:agents,
155:Yokohama
122:/commcms
1057:5999033
1000:5923120
943:3039483
808:5869464
634:3752428
405:(2019).
391:(2013).
378:(2000).
365:(1997).
358:(1995).
351:(1994).
259:taxanes
113:Website
71:(2019)
1064:
1054:
1046:
1007:
997:
989:
950:
940:
932:
893:
881:(16).
858:
850:
815:
805:
797:
751:
716:
682:
672:
641:
631:
623:
558:
548:
126:_group
124:/ojima
91:Fields
79:(1994)
64:Awards
977:(5).
680:S2CID
577:(PDF)
556:S2CID
271:Taxol
232:taxol
1062:PMID
1044:ISSN
1005:PMID
987:ISSN
948:PMID
930:ISSN
891:ISSN
856:PMID
848:ISSN
813:PMID
795:ISSN
749:ISSN
714:ISSN
670:ISBN
639:PMID
621:ISSN
546:ISBN
401:ACS
347:ACS
330:and
230:and
120:.edu
75:ACS
67:ACS
35:Born
1052:PMC
1036:doi
1032:154
995:PMC
979:doi
938:PMC
922:doi
883:doi
840:doi
803:PMC
787:doi
741:doi
706:doi
662:doi
629:PMC
613:doi
538:doi
1335::
1311:.
1287:.
1258:.
1242:90
1240:.
1236:.
1212:.
1188:.
1150:.
1126:.
1082:.
1060:.
1050:.
1042:.
1030:.
1026:.
1003:.
993:.
985:.
975:62
973:.
969:.
946:.
936:.
928:.
916:.
912:.
889:.
879:39
877:.
854:.
846:.
836:41
834:.
811:.
801:.
793:.
783:81
781:.
777:.
761:^
747:.
737:26
735:.
712:.
702:28
700:.
678:,
668:,
637:.
627:.
619:.
609:78
607:.
603:.
589:^
579:.
554:.
544:.
509:.
485:.
461:.
450:^
434:.
421:^
326:,
322:,
318:,
257:,
253:,
249:,
226:,
43:)
1321:.
1297:.
1273:.
1222:.
1198:.
1174:.
1160:.
1136:.
1112:.
1092:.
1068:.
1038::
1011:.
981::
954:.
924::
918:2
897:.
885::
862:.
842::
819:.
789::
755:.
743::
720:.
708::
664::
645:.
615::
583:.
562:.
540::
519:.
495:.
471:.
444:.
269:(
234:(
216:N
39:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
