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Lang, N.; Pereira, M. J.; Lee, Y.; Friehs, I.; Vasilyev, N. V.; Feins, E. N.; Ablasser, K.; O'Cearbhaill, E. D.; Xu, C.; Fabozzo, A.; Padera, R.; Wasserman, S.; Freudenthal, F.; Ferreira, L. S.; Langer, R.; Karp, J. M.; Del Nido, P. J. (2014).
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can also damage heart tissue. Existing surgical adhesives can be toxic, and they can become unstuck in wet, dynamic environments such as the heart. As a result, infants often require subsequent operations to "replug" the hole. One other
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seal that adheres to the heart tissue despite immersion in liquid blood. It is not rejected by the body and is sufficiently adhesive and elastic that it is not pulled loose or damaged by the contractions of the
173:. It harmlessly biodegrades over time. The lack of stitching or stapling implies that procedures for applying glue-treated patches are potentially considerably less invasive than the alternatives. The
124:. One biocompatible, biodegradable HLAA is under consideration for use in human tissue repair as a replacement for sutures, staples and other approaches.
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257:"A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects"
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HLAA has been used experimentally to repair holes in pig hearts. It provides a
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330:"Mending Damaged Hearts with Surgical Glue – MIT Technology Review"
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305:"New Glue Could Seal Heart Surgeries: Scientific American Podcast"
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can damage heart tissue and take too long to apply.
132:The glue was developed in a collaboration between
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234:"New superglue fixes holes in the heart"
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380:Surgical procedures and techniques
177:becomes physically entangled with
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261:Science Translational Medicine
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146:Brigham and Women's Hospital
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134:Boston Children's Hospital
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307:. scientificamerican.com
236:. Gizmag.com. 2014-01-10
375:Biodegradable materials
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332:. technologyreview.com
156:and insect footpads.
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334:. Retrieved
309:. Retrieved
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193:Alternatives
171:heart muscle
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160:Heart repair
144:-affiliated
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100:-affiliated
86:Manufacturer
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364:Categories
336:14 January
311:14 January
240:2014-01-14
213:References
181:and other
166:hemostatic
50:; try the
37:link to it
370:Adhesives
40:. Please
291:24401941
183:proteins
179:collagen
282:4157752
202:Staples
198:Sutures
175:polymer
142:Harvard
128:History
98:Harvard
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33:orphan
31:is an
150:slugs
338:2014
313:2014
287:PMID
140:and
118:glue
114:HLAA
80:Glue
76:Type
277:PMC
269:doi
138:MIT
94:MIT
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