1136:
1374:
44:
genome, which has five HIS elements; other human coronaviruses have one to five. It has been suggested that these sequences can be more generally termed "host identical sequences" since similar correlations have been found between the genome of SARS-CoV-2 and multiple potential hosts
913:
Li, W; Yang, S; Xu, P; Zhang, D; Tong, Y; Chen, L; Jia, B; Li, A; Lian, C; Ru, D; Zhang, B; Liu, M; Chen, C; Fu, W; Yuan, S; Gu, C; Wang, L; Li, W; Liang, Y; Yang, Z; Ren, X; Wang, S; Zhang, X; Song, Y; Xie, Y; Lu, H; Xu, J; Wang, H; Yu, W (February 2022).
963:
Yang, S; Ling, Y; Zhao, F; Li, W; Song, Z; Wang, L; Li, Q; Liu, M; Tong, Y; Chen, L; Ru, D; Zhang, T; Zhou, K; Zhang, B; Xu, P; Yang, Z; Li, W; Song, Y; Xu, J; Zhu, T; Shan, F; Yu, W; Lu, H (18 March 2022).
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1174:
1163:
1158:
1336:
1348:
1080:
1013:
Xiao M, Li J, Li W, Wang Y, Wu F, Xi Y, Zhang L, Ding C, Luo H, Li Y, Peng L, Zhao L, Peng S, Xiao Y, Dong S, Cao J, Yu W (October 2017).
190:
1415:
1331:
1073:
1124:
1135:
916:"SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network"
1343:
1118:
1112:
1066:
1408:
1144:
966:"Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression"
1106:
376:
1098:
1389:
1444:
1245:
1439:
1401:
1326:
1321:
316:
175:
1168:
8:
40:
network to activate neighboring host genes. The first HIS elements was identified in the
37:
1039:
1014:
990:
965:
940:
915:
1434:
1044:
995:
945:
1179:
1034:
1026:
985:
977:
935:
927:
186:
1030:
931:
1385:
981:
1428:
1015:"MicroRNAs activate gene transcription epigenetically as an enhancer trigger"
881:
801:
496:
491:
321:
180:
1048:
999:
949:
857:
776:
720:
696:
672:
648:
624:
568:
544:
520:
486:
481:
476:
471:
466:
461:
437:
381:
287:
282:
223:
153:
129:
102:
29:
1089:
25:
41:
21:
1058:
195:
50:
1381:
33:
1373:
1149:
277:
97:
1303:
1298:
1293:
1283:
1278:
1268:
1263:
1258:
1253:
201:
108:
1288:
1273:
297:
293:
1313:
46:
1426:
36:(nuclear activating miRNA) through the NamiRNA-
962:
1409:
1349:Coronavirus frameshifting stimulation element
1074:
912:
1337:Coronavirus 3′ stem-loop II-like motif (s2m)
1012:
32:. In pathogenic progression, HIS acts as a
1416:
1402:
1081:
1067:
1038:
989:
939:
970:Signal Transduction and Targeted Therapy
1088:
1427:
1062:
20:is a sequence of RNA elements, 24-27
1368:
908:
906:
904:
13:
14:
1456:
956:
901:
1372:
1134:
1006:
18:human identical sequence (HIS)
1:
1332:Coronavirus 3′ UTR pseudoknot
1031:10.1080/15476286.2015.1112487
894:
236:
56:
1388:. You can help Knowledge by
1344:Coronavirus packaging signal
814:
733:
581:
394:
7:
1145:Viral nonstructural protein
932:10.1016/j.ebiom.2022.103861
335:
312:AGGAGAAUGACAAAAAAAAAAAAAAAA
171:AGGAGAAUGACAAAAAAAAAAAAAAAA
10:
1461:
1367:
982:10.1038/s41392-022-00952-w
93:UGUCUAUGCUAAUGGAGGUAAAGGCU
1312:
1244:
1143:
1132:
1097:
273:UAACAUGCUUAGGAUAAUGGCCUCU
1354:Human identical sequence
1236:nonstructural protein 16
1231:nonstructural protein 15
1226:nonstructural protein 14
1221:nonstructural protein 13
1216:nonstructural protein 12
1211:nonstructural protein 11
1206:nonstructural protein 10
1099:Viral structural protein
875:ACUUUGUAUUGUGUCCUCCUGGAA
851:AAUAUUUUAACAGUACCACGUUAU
834:location in human genome
831:location in virus genome
795:UUGUAUGAGUGAUUUUAUGAGUGA
770:UACAGCUCUUUGUAAAUCUGGUAG
753:location in human genome
750:location in virus genome
714:AACUUUUAUGAUUUUGGUGAUUUU
690:AAGUAAUUGUAUUAAGAUGUUAUC
666:AUAGGCUUAAAUGCUUCUGUUACU
642:GGUGUUUUUGUUGAUGAUGUUGUU
618:UUAUGAUUUUGGUGAUUUUGUUGU
601:location in human genome
598:location in virus genome
562:UAGAUACUGUUAUUUUUAAAAAUA
538:GAUUGGUUGUAUUUUCAUUUUUAU
514:AUUUGACUUUAAAUCUUCAUACUA
455:UUUUCUAAGAAAGAUUGGUAUGAU
431:UUAGAAUUGUUCAAAUGUUAUCUG
414:location in human genome
411:location in virus genome
372:UUCCAUUUGCACAGAGUAUCUUUU
355:location in human genome
352:location in virus genome
256:location in human genome
253:location in virus genome
217:UUGUUGCUGCUAUUUUCUAUUUAA
147:UUAUAUGCCUUAUUUCUUUACUUU
123:UAUAACACAUATAAAAAUACGUGU
76:location in human genome
73:location in virus genome
1246:Viral accessory protein
1201:nonstructural protein 9
1196:nonstructural protein 8
1191:nonstructural protein 7
1186:nonstructural protein 6
1175:nonstructural protein 4
1164:nonstructural protein 2
1159:nonstructural protein 1
28:genomes share with the
53:, ferrets, and cats).
290:: 122356667-122356690
285:: 172887105–172887129
132:: 176597319-176597342
105:: 124017420-124017395
1169:papain-like protease
1125:nucleocapsid protein
884::112451251-112451274
779::122471006-122471029
627::215311768-215311791
479::111192947-111192970
469::151100495-151100518
464::226438633-226438656
440::106816197-106816220
329:same as HIS-SARS2-4
206:same as HIS-SARS1-2
126:12494–12517 in ORF1a
384:: 25635779-25635802
324:: 73670168-73670142
226:: 99693480-99693457
183:: 73670168-73670142
156:: 28949255-28949232
1327:Coronavirus 3′ UTR
1322:Coronavirus 5′ UTR
860::42865576-42865599
804::30510223-30510246
699::19853545-19853568
675::30469931-30469954
651::28254452-28254475
571::81711130-81711153
547::33759646-33759669
523::11718458-11718481
499::30137367-30137390
494::59768424-59768447
489::98386489-98386512
484::94695722-94695745
474::79284823-79284846
220:8610–8633 in ORF1a
150:6766–6789 in ORF1a
1397:
1396:
1362:
1361:
1025:(10): 1326–1334.
892:
891:
837:neighboring genes
812:
811:
756:neighboring genes
731:
730:
604:neighboring genes
579:
578:
417:neighboring genes
392:
391:
358:neighboring genes
333:
332:
259:neighboring genes
234:
233:
79:neighboring genes
1452:
1418:
1411:
1404:
1376:
1369:
1180:3C-like protease
1148:(expressed from
1138:
1119:membrane protein
1113:envelope protein
1083:
1076:
1069:
1060:
1059:
1053:
1052:
1042:
1010:
1004:
1003:
993:
960:
954:
953:
943:
910:
819:
818:
738:
737:
723::1525276-1525299
586:
585:
399:
398:
340:
339:
241:
240:
199:
61:
60:
24:in length, that
1460:
1459:
1455:
1454:
1453:
1451:
1450:
1449:
1425:
1424:
1423:
1422:
1365:
1363:
1358:
1308:
1240:
1147:
1139:
1130:
1093:
1087:
1057:
1056:
1011:
1007:
961:
957:
911:
902:
897:
817:
736:
584:
495:
490:
485:
480:
475:
470:
465:
397:
375:24364–24387 in
338:
315:29717–29743 in
286:
276:15251–15275 in
239:
193:
174:29860–29886 in
59:
12:
11:
5:
1458:
1448:
1447:
1445:Genetics stubs
1442:
1437:
1421:
1420:
1413:
1406:
1398:
1395:
1394:
1377:
1360:
1359:
1357:
1356:
1351:
1346:
1341:
1340:
1339:
1334:
1324:
1318:
1316:
1310:
1309:
1307:
1306:
1301:
1296:
1291:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1250:
1248:
1242:
1241:
1239:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1177:
1172:
1166:
1161:
1155:
1153:
1141:
1140:
1133:
1131:
1129:
1128:
1122:
1116:
1110:
1103:
1101:
1095:
1094:
1086:
1085:
1078:
1071:
1063:
1055:
1054:
1005:
955:
899:
898:
896:
893:
890:
889:
887:
885:
879:
876:
873:
870:
866:
865:
863:
861:
855:
852:
849:
846:
842:
841:
838:
835:
832:
829:
826:
823:
816:
813:
810:
809:
807:
805:
799:
796:
793:
790:
786:
785:
783:
780:
774:
771:
768:
765:
761:
760:
757:
754:
751:
748:
745:
742:
735:
732:
729:
728:
726:
724:
718:
715:
712:
709:
705:
704:
702:
700:
694:
691:
688:
685:
681:
680:
678:
676:
670:
667:
664:
661:
657:
656:
654:
652:
646:
643:
640:
637:
633:
632:
630:
628:
622:
619:
616:
613:
609:
608:
605:
602:
599:
596:
593:
590:
583:
580:
577:
576:
574:
572:
566:
563:
560:
557:
553:
552:
550:
548:
542:
539:
536:
533:
529:
528:
526:
524:
518:
515:
512:
509:
505:
504:
502:
500:
459:
456:
453:
450:
446:
445:
443:
441:
435:
432:
429:
426:
422:
421:
418:
415:
412:
409:
406:
403:
396:
393:
390:
389:
387:
385:
379:
373:
370:
367:
363:
362:
359:
356:
353:
350:
347:
344:
337:
334:
331:
330:
327:
325:
319:
313:
310:
307:
303:
302:
300:
291:
280:
274:
271:
268:
264:
263:
260:
257:
254:
251:
248:
245:
238:
235:
232:
231:
229:
227:
221:
218:
215:
212:
208:
207:
204:
184:
178:
172:
169:
166:
162:
161:
159:
157:
151:
148:
145:
142:
138:
137:
135:
133:
127:
124:
121:
118:
114:
113:
111:
106:
100:
94:
91:
88:
84:
83:
80:
77:
74:
71:
68:
65:
58:
55:
9:
6:
4:
3:
2:
1457:
1446:
1443:
1441:
1440:Coronaviridae
1438:
1436:
1433:
1432:
1430:
1419:
1414:
1412:
1407:
1405:
1400:
1399:
1393:
1391:
1387:
1384:article is a
1383:
1378:
1375:
1371:
1370:
1366:
1355:
1352:
1350:
1347:
1345:
1342:
1338:
1335:
1333:
1330:
1329:
1328:
1325:
1323:
1320:
1319:
1317:
1315:
1311:
1305:
1302:
1300:
1297:
1295:
1292:
1290:
1287:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1251:
1249:
1247:
1243:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1184:
1181:
1178:
1176:
1173:
1170:
1167:
1165:
1162:
1160:
1157:
1156:
1154:
1151:
1146:
1142:
1137:
1126:
1123:
1120:
1117:
1114:
1111:
1108:
1107:spike protein
1105:
1104:
1102:
1100:
1096:
1091:
1084:
1079:
1077:
1072:
1070:
1065:
1064:
1061:
1050:
1046:
1041:
1036:
1032:
1028:
1024:
1020:
1016:
1009:
1001:
997:
992:
987:
983:
979:
975:
971:
967:
959:
951:
947:
942:
937:
933:
929:
925:
921:
917:
909:
907:
905:
900:
888:
886:
883:
880:
877:
874:
871:
868:
867:
864:
862:
859:
856:
853:
850:
847:
844:
843:
839:
836:
833:
830:
827:
824:
821:
820:
808:
806:
803:
800:
797:
794:
791:
788:
787:
784:
781:
778:
775:
772:
769:
766:
763:
762:
758:
755:
752:
749:
746:
743:
740:
739:
727:
725:
722:
719:
716:
713:
710:
707:
706:
703:
701:
698:
695:
692:
689:
686:
683:
682:
679:
677:
674:
671:
668:
665:
662:
659:
658:
655:
653:
650:
647:
644:
641:
638:
635:
634:
631:
629:
626:
623:
620:
617:
614:
611:
610:
606:
603:
600:
597:
594:
591:
588:
587:
575:
573:
570:
567:
564:
561:
558:
555:
554:
551:
549:
546:
543:
540:
537:
534:
531:
530:
527:
525:
522:
519:
516:
513:
510:
507:
506:
503:
501:
498:
493:
488:
483:
478:
473:
468:
463:
460:
457:
454:
451:
448:
447:
444:
442:
439:
436:
433:
430:
427:
424:
423:
419:
416:
413:
410:
407:
404:
401:
400:
388:
386:
383:
380:
378:
374:
371:
368:
365:
364:
360:
357:
354:
351:
348:
345:
342:
341:
328:
326:
323:
320:
318:
314:
311:
308:
305:
304:
301:
299:
295:
292:
289:
284:
281:
279:
275:
272:
269:
266:
265:
261:
258:
255:
252:
249:
246:
243:
242:
230:
228:
225:
222:
219:
216:
213:
210:
209:
205:
203:
197:
192:
188:
185:
182:
179:
177:
173:
170:
167:
164:
163:
160:
158:
155:
152:
149:
146:
143:
140:
139:
136:
134:
131:
128:
125:
122:
119:
116:
115:
112:
110:
107:
104:
101:
99:
96:7570–7595 in
95:
92:
89:
86:
85:
81:
78:
75:
72:
69:
66:
63:
62:
54:
52:
48:
43:
39:
35:
31:
27:
23:
19:
1390:expanding it
1379:
1364:
1353:
1022:
1018:
1008:
973:
969:
958:
923:
920:EBioMedicine
919:
30:human genome
17:
15:
1090:Coronavirus
1019:RNA Biology
878:13139-13162
854:19817-19840
798:24509-24532
773:22827-22850
717:13039-13062
693:12124-12147
669:20754-20777
645:14920-14943
621:13044-13067
565:19844-19867
541:23527-23550
517:26693-26716
458:14044-14067
434:18656-18679
211:HIS-SARS2-5
194: [
165:HIS-SARS2-4
141:HIS-SARS2-3
117:HIS-SARS2-2
87:HIS-SARS2-1
26:coronavirus
22:nucleotides
1429:Categories
926:: 103861.
895:References
869:HIS-229E-2
845:HIS-229E-1
789:HIS-OC43-2
782:HAS2, ZHX2
764:HIS-OC43-1
708:HIS-NL63-5
684:HIS-NL63-4
660:HIS-NL63-3
636:HIS-NL63-2
612:HIS-NL63-1
556:HIS-HKU1-5
532:HIS-HKU1-4
508:HIS-HKU1-3
449:HIS-HKU1-2
425:HIS-HKU1-1
366:HIS-MERS-1
306:HIS-SARS-2
267:HIS-SARS-1
237:SARS-CoV-1
57:SARS-CoV-2
42:SARS-CoV-2
976:(1): 91.
815:HCoV-229E
734:HCoV-OC43
582:HCoV-NL63
395:HCoV-HKU1
51:pangolins
1435:MicroRNA
1382:genetics
1049:26853707
1000:35304437
950:35124429
828:sequence
747:sequence
595:sequence
408:sequence
349:sequence
336:MERS-CoV
250:sequence
70:sequence
38:enhancer
1092:genomes
1040:5711461
991:8931182
941:8811534
34:NamiRNA
1182:(nsp5)
1171:(nsp3)
1150:ORF1ab
1047:
1037:
998:
988:
948:
938:
825:length
744:length
592:length
405:length
346:length
317:3' UTR
247:length
191:TIMM21
187:FBXO15
176:3' UTR
67:length
1380:This
1304:ORF10
1299:ORF9c
1294:ORF9b
1284:ORF7b
1279:ORF7a
1269:ORF3d
1264:ORF3c
1259:ORF3b
1254:ORF3a
882:chr11
840:note
802:chr13
759:note
607:note
497:chr22
492:chr15
420:note
361:note
322:Chr18
278:ORF1b
262:note
202:CYB5A
198:]
181:Chr18
109:KALRN
98:ORF1a
82:note
1386:stub
1289:ORF8
1274:ORF6
1045:PMID
996:PMID
946:PMID
858:chr8
822:name
777:chr8
741:name
721:chr9
697:chr7
673:chr6
649:chr4
625:chr1
589:name
569:chrX
545:chr4
521:chr4
487:chr7
482:chr7
477:chr5
472:chr5
467:chr4
462:chr1
438:chr1
402:name
382:ChrX
343:name
298:ZHX2
294:HAS2
288:Chr8
283:Chr4
244:name
224:ChrX
154:Chr5
130:Chr3
103:Chr3
64:name
47:bats
16:The
1314:RNA
1127:(N)
1121:(M)
1115:(E)
1109:(S)
1035:PMC
1027:doi
986:PMC
978:doi
936:PMC
928:doi
1431::
1043:.
1033:.
1023:14
1021:.
1017:.
994:.
984:.
972:.
968:.
944:.
934:.
924:76
922:.
918:.
903:^
872:24
848:24
792:24
767:24
711:24
687:24
663:24
639:24
615:24
559:24
535:24
511:24
452:24
428:24
369:24
309:27
296:,
270:25
214:24
200:,
196:uk
189:,
168:27
144:24
120:24
90:26
49:,
1417:e
1410:t
1403:v
1392:.
1152:)
1082:e
1075:t
1068:v
1051:.
1029::
1002:.
980::
974:7
952:.
930::
377:S
45:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.