211:
has been used for multiple purposes in the past, and some cells called "histocytes" do not appear to derive from monocytic-macrophage lines. The term
Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue (as in rheumatoid arthritis as palisading
321:
are derived from common bone marrow precursor cells that have undergone different differentiation (as histiocytes) under the influence of various environmental (tissue location) and growth factors such as GM-CSF,
529:
653:
357:
Dendritic cells have an indented (bean-shaped) nucleus and cytoplasm with thin processes (dendritic). Their main activity is antigen presentation; they express
101:
533:
398:. Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, as do cortical
1242:
646:
1160:
773:
200:. They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the
137:(also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's
494:
Chorro L, Geissmann F (December 2010). "Development and homeostasis of 'resident' myeloid cells: the case of the
Langerhans cell".
639:
430:
1235:
426:
406:
gland). They also express S-100, and their cytoplasm contains tennis-racket like ultra-structural inclusions called
108:
1634:
220:
201:
96:
1516:
1228:
1043:
851:
134:
17:
1553:
89:
1541:
1378:
1324:
1578:
1573:
1336:
1105:
260:
84:
72:
1207:
1126:
995:
366:
1475:
395:
323:
1629:
1588:
1427:
1432:
1202:
425:
wherein the proliferative cell is the histiocyte. The most common histiocyte disorders are
327:
296:
8:
1583:
1511:
1437:
1368:
990:
965:
383:
1401:
1136:
613:
596:
1568:
1563:
1000:
618:
577:
511:
1494:
1416:
1077:
980:
795:
608:
567:
503:
474:
407:
379:
343:
256:
142:
572:
555:
479:
462:
291:
These histiocytes are part of the immune system by way of two distinct functions:
1026:
815:
747:
631:
216:
77:
1558:
1521:
1301:
1260:
1092:
1072:
1021:
865:
810:
790:
785:
707:
671:
318:
308:
236:
149:
130:
1623:
1406:
1331:
1172:
1082:
727:
507:
442:
418:
326:
and IL-4. The various categories of histiocytes are distinguishable by their
280:
138:
48:
1546:
1396:
1285:
1280:
1275:
1197:
1131:
1100:
960:
825:
717:
680:
663:
515:
292:
244:
43:
622:
581:
1533:
1442:
1355:
1319:
1309:
1251:
874:
757:
387:
358:
185:
1503:
1470:
1452:
1350:
985:
975:
947:
909:
892:
882:
820:
712:
422:
399:
314:
300:
173:
145:
1220:
350:– in relation to their specialised phagocytic function. They express
114:
1360:
1345:
1192:
1038:
970:
921:
887:
752:
732:
722:
347:
339:
331:
240:
232:
197:
189:
1604:
1480:
1314:
1165:
1059:
938:
926:
902:
897:
685:
248:
212:
histiocytes surrounding fibrinoid necrosis of rheumatoid nodules).
1067:
914:
304:
252:
1155:
1031:
695:
403:
391:
338:
Macrophages are highly variable in size and morphology, their
311:(so called because of their star-like cytoplasmic processes).
1110:
193:
60:
351:
272:
268:
264:
362:
276:
192:. The derived cells migrate from the bone marrow to the
259:
and the fragment C3b of complement. They express LCAs (
235:
and immunophenotypical characteristics (demonstrated by
679:
661:
286:
522:
176:once they've reached the end of their lifespan.
1621:
493:
1236:
647:
1243:
1229:
654:
640:
588:
223:embeds this interpretation into its name.
612:
571:
478:
454:
413:
1250:
1161:Megakaryocyte–erythroid progenitor cell
14:
1622:
378:A subset of cells differentiates into
299:. Phagocytosis is the main process of
1224:
635:
553:
460:
172:). Part of their job is to clear out
594:
251:. They bear membrane receptors for
431:haemophagocytic lymphohistiocytosis
373:
219:derivatives to be histiocytes. The
24:
614:10.1093/oxfordjournals.bmb.a011585
307:presentation the main property of
25:
1646:
247:and contains variable amounts of
184:Histiocytes are derived from the
382:; this maturation occurs in the
109:Anatomical terms of microanatomy
556:"Histiocytes and histiocytosis"
463:"Histiocytes and histiocytosis"
287:Macrophages and dendritic cells
547:
487:
427:Langerhans' cell histiocytosis
179:
13:
1:
573:10.1182/blood.V84.9.2840.2840
480:10.1182/blood.V84.9.2840.2840
461:Cline, Mj (1 November 1994).
448:
221:Langerhans cell histiocytosis
202:mononuclear phagocytic system
852:Extramedullary hematopoiesis
402:(cells of the cortex of the
226:
135:mononuclear phagocyte system
7:
436:
10:
1651:
554:Cline MJ (November 1994).
1597:
1542:Hypersegmented neutrophil
1532:
1502:
1493:
1463:
1449:Hemoglobin precipitation
1415:
1389:
1379:Hereditary stomatocytosis
1325:Hereditary elliptocytosis
1294:
1268:
1259:
1185:
1145:
1119:
1091:
1058:
1018:Antigen-presenting cells
1011:
946:
937:
873:
864:
844:
806:
781:
772:
743:
703:
694:
670:
261:leucocyte common antigens
188:by multiplication from a
107:
95:
83:
71:
66:macrophagocytus immobilis
59:
54:
42:
37:
32:
1574:Critical green inclusion
1365:Sickle cell/drepanocyte
1337:Hereditary spherocytosis
1106:Nucleated red blood cell
662:Myeloid blood cells and
601:British Medical Bulletin
595:Webb DK (October 1996).
508:10.1016/j.it.2010.09.003
367:Human leukocyte antigens
231:Histiocytes have common
1306:Membrane abnormalities
1208:Hematopoietic stem cell
1127:Leukocyte extravasation
996:Foreign-body giant cell
1635:Mononuclear phagocytes
1476:Red cell agglutination
597:"Histiocyte disorders"
396:bronchiolar epithelium
215:Some sources consider
141:. The histiocyte is a
414:Clinical significance
1579:Alder–Reilly anomaly
1433:Basophilic stippling
1203:Hematopoietic system
991:Langhans giant cells
496:Trends in Immunology
297:antigen presentation
133:that is part of the
1554:Pelger–Huët anomaly
1512:Reactive lymphocyte
1438:Pappenheimer bodies
1369:Sickle cell disease
966:Alveolar macrophage
384:squamous epithelium
279:(also expressed by
1402:Hypochromic anemia
1137:Intrinsic immunity
1001:Touton giant cells
342:contains numerous
207:However, the term
129:is a vertebrate
102:84642 83585, 84642
90:H2.00.03.0.01009
1617:
1616:
1613:
1612:
1569:Toxic vacuolation
1564:Toxic granulation
1495:White blood cells
1489:
1488:
1428:Howell–Jolly body
1218:
1217:
1181:
1180:
1054:
1053:
981:Epithelioid cells
860:
859:
840:
839:
836:
835:
768:
767:
530:"S12C3-Granuloma"
123:
122:
118:
16:(Redirected from
1642:
1584:Jordans' anomaly
1500:
1499:
1417:Inclusion bodies
1266:
1265:
1245:
1238:
1231:
1222:
1221:
1152:Precursor cells
1078:Promegakaryocyte
944:
943:
871:
870:
796:Promegakaryocyte
779:
778:
701:
700:
692:
691:
677:
676:
656:
649:
642:
633:
632:
627:
626:
616:
592:
586:
585:
575:
551:
545:
544:
542:
541:
532:. Archived from
526:
520:
519:
491:
485:
484:
482:
473:(9): 2840–2853.
458:
408:Birbeck granules
380:Langerhans cells
374:Langerhans cells
344:acid phosphatase
156:, diminutive of
115:edit on Wikidata
112:
30:
29:
21:
1650:
1649:
1645:
1644:
1643:
1641:
1640:
1639:
1620:
1619:
1618:
1609:
1593:
1528:
1485:
1459:
1411:
1385:
1290:
1261:Red blood cells
1255:
1249:
1219:
1214:
1177:
1141:
1120:Immune response
1115:
1093:Red blood cells
1087:
1050:
1027:Langerhans cell
1022:Dendritic cells
1007:
933:
856:
832:
816:Proerythroblast
802:
764:
748:Monocytopoiesis
739:
683:
666:
660:
630:
593:
589:
552:
548:
539:
537:
528:
527:
523:
492:
488:
459:
455:
451:
439:
416:
376:
365:, and Class II
319:dendritic cells
309:dendritic cells
289:
229:
217:Langerhans cell
182:
119:
28:
27:Vertebrate cell
23:
22:
15:
12:
11:
5:
1648:
1638:
1637:
1632:
1615:
1614:
1611:
1610:
1608:
1607:
1601:
1599:
1595:
1594:
1592:
1591:
1586:
1581:
1576:
1571:
1566:
1561:
1556:
1551:
1550:
1549:
1538:
1536:
1530:
1529:
1527:
1526:
1525:
1524:
1522:Russell bodies
1514:
1508:
1506:
1497:
1491:
1490:
1487:
1486:
1484:
1483:
1478:
1473:
1467:
1465:
1461:
1460:
1458:
1457:
1456:
1455:
1447:
1446:
1445:
1440:
1435:
1430:
1424:Developmental
1421:
1419:
1413:
1412:
1410:
1409:
1404:
1399:
1393:
1391:
1387:
1386:
1384:
1383:
1382:
1381:
1373:
1372:
1371:
1363:
1358:
1353:
1348:
1343:
1342:
1341:
1340:
1339:
1329:
1328:
1327:
1317:
1312:
1304:
1302:Poikilocytosis
1298:
1296:
1292:
1291:
1289:
1288:
1283:
1278:
1272:
1270:
1263:
1257:
1256:
1248:
1247:
1240:
1233:
1225:
1216:
1215:
1213:
1212:
1211:
1210:
1200:
1195:
1189:
1187:
1183:
1182:
1179:
1178:
1176:
1175:
1170:
1169:
1168:
1163:
1158:
1149:
1147:
1143:
1142:
1140:
1139:
1134:
1129:
1123:
1121:
1117:
1116:
1114:
1113:
1108:
1103:
1097:
1095:
1089:
1088:
1086:
1085:
1080:
1075:
1073:Megakaryoblast
1070:
1064:
1062:
1056:
1055:
1052:
1051:
1049:
1048:
1047:
1046:
1036:
1035:
1034:
1029:
1024:
1015:
1013:
1009:
1008:
1006:
1005:
1004:
1003:
998:
993:
983:
978:
973:
968:
963:
958:
952:
950:
941:
935:
934:
932:
931:
930:
929:
919:
918:
917:
907:
906:
905:
895:
890:
885:
879:
877:
868:
866:Myeloid tissue
862:
861:
858:
857:
855:
854:
848:
846:
842:
841:
838:
837:
834:
833:
831:
830:
829:
828:
823:
818:
811:Erythropoiesis
807:
804:
803:
801:
800:
799:
798:
793:
791:Megakaryoblast
786:Thrombopoiesis
782:
776:
770:
769:
766:
765:
763:
762:
761:
760:
755:
744:
741:
740:
738:
737:
736:
735:
730:
725:
720:
715:
708:Granulopoiesis
704:
698:
689:
674:
668:
667:
659:
658:
651:
644:
636:
629:
628:
587:
566:(9): 2840–53.
546:
521:
502:(12): 438–45.
486:
452:
450:
447:
446:
445:
438:
435:
415:
412:
375:
372:
371:
370:
355:
288:
285:
281:T helper cells
228:
225:
181:
178:
150:dendritic cell
121:
120:
111:
105:
104:
99:
93:
92:
87:
81:
80:
75:
69:
68:
63:
57:
56:
52:
51:
46:
40:
39:
35:
34:
26:
9:
6:
4:
3:
2:
1647:
1636:
1633:
1631:
1628:
1627:
1625:
1606:
1603:
1602:
1600:
1596:
1590:
1587:
1585:
1582:
1580:
1577:
1575:
1572:
1570:
1567:
1565:
1562:
1560:
1557:
1555:
1552:
1548:
1545:
1544:
1543:
1540:
1539:
1537:
1535:
1531:
1523:
1520:
1519:
1518:
1515:
1513:
1510:
1509:
1507:
1505:
1501:
1498:
1496:
1492:
1482:
1479:
1477:
1474:
1472:
1469:
1468:
1466:
1462:
1454:
1451:
1450:
1448:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1425:
1423:
1422:
1420:
1418:
1414:
1408:
1407:Polychromasia
1405:
1403:
1400:
1398:
1395:
1394:
1392:
1388:
1380:
1377:
1376:
1374:
1370:
1367:
1366:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1338:
1335:
1334:
1333:
1330:
1326:
1323:
1322:
1321:
1318:
1316:
1313:
1311:
1308:
1307:
1305:
1303:
1300:
1299:
1297:
1293:
1287:
1284:
1282:
1279:
1277:
1274:
1273:
1271:
1267:
1264:
1262:
1258:
1253:
1246:
1241:
1239:
1234:
1232:
1227:
1226:
1223:
1209:
1206:
1205:
1204:
1201:
1199:
1196:
1194:
1191:
1190:
1188:
1184:
1174:
1173:Myelomonocyte
1171:
1167:
1164:
1162:
1159:
1157:
1154:
1153:
1151:
1150:
1148:
1144:
1138:
1135:
1133:
1130:
1128:
1125:
1124:
1122:
1118:
1112:
1109:
1107:
1104:
1102:
1099:
1098:
1096:
1094:
1090:
1084:
1083:Megakaryocyte
1081:
1079:
1076:
1074:
1071:
1069:
1066:
1065:
1063:
1061:
1057:
1045:
1042:
1041:
1040:
1037:
1033:
1030:
1028:
1025:
1023:
1020:
1019:
1017:
1016:
1014:
1010:
1002:
999:
997:
994:
992:
989:
988:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
961:Kupffer cells
959:
957:
954:
953:
951:
949:
945:
942:
940:
936:
928:
925:
924:
923:
920:
916:
913:
912:
911:
908:
904:
901:
900:
899:
896:
894:
891:
889:
886:
884:
881:
880:
878:
876:
872:
869:
867:
863:
853:
850:
849:
847:
843:
827:
824:
822:
819:
817:
814:
813:
812:
809:
808:
805:
797:
794:
792:
789:
788:
787:
784:
783:
780:
777:
775:
771:
759:
756:
754:
751:
750:
749:
746:
745:
742:
734:
731:
729:
728:Metamyelocyte
726:
724:
721:
719:
716:
714:
711:
710:
709:
706:
705:
702:
699:
697:
693:
690:
687:
682:
678:
675:
673:
672:Hematopoiesis
669:
665:
657:
652:
650:
645:
643:
638:
637:
634:
624:
620:
615:
610:
607:(4): 818–25.
606:
602:
598:
591:
583:
579:
574:
569:
565:
561:
557:
550:
536:on 2009-09-29
535:
531:
525:
517:
513:
509:
505:
501:
497:
490:
481:
476:
472:
468:
464:
457:
453:
444:
443:Histiocytosis
441:
440:
434:
432:
428:
424:
420:
419:Histiocytoses
411:
409:
405:
401:
397:
393:
389:
385:
381:
368:
364:
360:
356:
353:
349:
345:
341:
337:
336:
335:
333:
329:
325:
320:
316:
312:
310:
306:
302:
298:
294:
284:
282:
278:
274:
270:
266:
262:
258:
254:
250:
246:
242:
238:
234:
224:
222:
218:
213:
210:
205:
203:
199:
195:
191:
187:
177:
175:
171:
167:
163:
159:
155:
151:
147:
144:
140:
139:immune system
136:
132:
128:
116:
110:
106:
103:
100:
98:
94:
91:
88:
86:
82:
79:
76:
74:
70:
67:
64:
62:
58:
53:
50:
49:Immune system
47:
45:
41:
36:
31:
19:
1630:Cell biology
1559:Döhle bodies
1547:Arneth count
1534:Granulocytes
1397:Anisochromia
1375:Stomatocyte
1286:Microcytosis
1281:Macrocytosis
1276:Anisocytosis
1132:Phagocytosis
1101:Reticulocyte
955:
875:Granulocytes
826:Reticulocyte
718:Promyelocyte
681:Myelopoiesis
604:
600:
590:
563:
559:
549:
538:. Retrieved
534:the original
524:
499:
495:
489:
470:
466:
456:
417:
377:
359:Factor XIIIa
334:, and size.
313:
293:phagocytosis
290:
245:eosinophilic
237:immunostains
233:histological
230:
214:
208:
206:
183:
169:
165:
161:
157:
153:
126:
124:
65:
1517:Smudge cell
1504:Lymphocytes
1443:Cabot rings
1356:Schistocyte
1320:Elliptocyte
1310:Acanthocyte
986:giant cells
976:Osteoclasts
956:Histiocytes
948:Macrophages
758:Promonocyte
388:lymph nodes
315:Macrophages
301:macrophages
186:bone marrow
180:Development
174:neutrophils
55:Identifiers
18:Histiocytes
1624:Categories
1589:Left shift
1471:Haemoconia
1453:Heinz body
1351:Echinocyte
1332:Spherocyte
1252:Blood film
910:Eosinophil
893:Neutrophil
883:Myeloblast
821:Normoblast
713:Myeloblast
540:2009-01-06
449:References
423:neoplasias
400:thymocytes
328:morphology
255:, such as
239:). Their
209:histiocyte
168:, meaning
160:, meaning
146:macrophage
127:histiocyte
33:Histiocyte
1361:Degmacyte
1346:Dacrocyte
1193:Phagocyte
1060:Platelets
1039:Monoblast
971:Microglia
939:Monocytes
922:Mast cell
888:Band cell
753:Monoblast
733:Band cell
723:Myelocyte
421:describe
348:lysosomes
340:cytoplasm
332:phenotype
249:lysosomes
241:cytoplasm
227:Structure
198:monocytes
190:stem cell
1605:Auer rod
1481:Rouleaux
1315:Codocyte
1254:findings
1166:CFU-GEMM
927:CFU-Mast
903:CFU-Baso
898:Basophil
686:CFU-GEMM
516:21030305
437:See also
253:opsonins
1068:CFU-Meg
915:CFU-Eos
845:General
623:9039734
582:7524755
305:antigen
204:(MPS).
78:D006644
38:Details
1390:Colour
1198:Plasma
1156:CFU-GM
1032:CFU-DL
696:CFU-GM
664:plasma
621:
580:
514:
404:thymus
394:, and
392:spleen
346:laden
275:, and
164:, and
162:tissue
154:histio
143:tissue
44:System
1598:Other
1464:Other
1295:Shape
1186:Other
1146:Other
1111:CFU-E
1012:Other
560:Blood
467:Blood
194:blood
158:histo
148:or a
113:[
61:Latin
1269:Size
619:PMID
578:PMID
512:PMID
429:and
363:CD1c
352:CD68
317:and
303:and
295:and
273:CD33
269:CD14
265:CD45
170:cell
166:cyte
131:cell
73:MeSH
1044:MPS
774:MEP
609:doi
568:doi
504:doi
475:doi
324:TNF
283:).
277:CD4
257:IgG
243:is
196:as
97:FMA
1626::
617:.
605:52
603:.
599:.
576:.
564:84
562:.
558:.
510:.
500:31
498:.
471:84
469:.
465:.
433:.
410:.
390:,
386:,
361:,
330:,
271:,
267:,
263:)
125:A
85:TH
1244:e
1237:t
1230:v
688:)
684:(
655:e
648:t
641:v
625:.
611::
584:.
570::
543:.
518:.
506::
483:.
477::
369:.
354:.
152:(
117:]
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.