200:
has been used for multiple purposes in the past, and some cells called "histocytes" do not appear to derive from monocytic-macrophage lines. The term
Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue (as in rheumatoid arthritis as palisading
310:
are derived from common bone marrow precursor cells that have undergone different differentiation (as histiocytes) under the influence of various environmental (tissue location) and growth factors such as GM-CSF,
518:
642:
346:
Dendritic cells have an indented (bean-shaped) nucleus and cytoplasm with thin processes (dendritic). Their main activity is antigen presentation; they express
90:
522:
387:. Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, as do cortical
1231:
635:
1149:
762:
189:. They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the
126:(also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's
483:
Chorro L, Geissmann F (December 2010). "Development and homeostasis of 'resident' myeloid cells: the case of the
Langerhans cell".
628:
419:
1224:
415:
395:
gland). They also express S-100, and their cytoplasm contains tennis-racket like ultra-structural inclusions called
97:
1623:
209:
190:
85:
1505:
1217:
1032:
840:
123:
1542:
78:
1530:
1367:
1313:
1567:
1562:
1325:
1094:
249:
73:
61:
1196:
1115:
984:
355:
1464:
384:
312:
1618:
1577:
1416:
1421:
1191:
414:
wherein the proliferative cell is the histiocyte. The most common histiocyte disorders are
316:
285:
8:
1572:
1500:
1426:
1357:
979:
954:
372:
1390:
1125:
602:
585:
1557:
1552:
989:
607:
566:
500:
1483:
1405:
1066:
969:
784:
597:
556:
492:
463:
396:
368:
332:
245:
131:
561:
544:
468:
451:
280:
These histiocytes are part of the immune system by way of two distinct functions:
1015:
804:
736:
620:
205:
66:
1547:
1510:
1290:
1249:
1081:
1061:
1010:
854:
799:
779:
774:
696:
660:
307:
297:
225:
138:
119:
1612:
1395:
1320:
1161:
1071:
716:
496:
431:
407:
315:
and IL-4. The various categories of histiocytes are distinguishable by their
269:
127:
37:
1535:
1385:
1274:
1269:
1264:
1186:
1120:
1089:
949:
814:
706:
669:
652:
504:
281:
233:
32:
611:
570:
1522:
1431:
1344:
1308:
1298:
1240:
863:
746:
376:
347:
174:
1492:
1459:
1441:
1339:
974:
964:
936:
898:
881:
871:
809:
701:
411:
388:
303:
289:
162:
134:
1209:
339:– in relation to their specialised phagocytic function. They express
103:
1349:
1334:
1181:
1027:
959:
910:
876:
741:
721:
711:
336:
328:
320:
229:
221:
186:
178:
1593:
1469:
1303:
1154:
1048:
927:
915:
891:
886:
674:
237:
201:
histiocytes surrounding fibrinoid necrosis of rheumatoid nodules).
1056:
903:
293:
241:
1144:
1020:
684:
392:
380:
327:
Macrophages are highly variable in size and morphology, their
300:(so called because of their star-like cytoplasmic processes).
1099:
182:
49:
340:
261:
257:
253:
351:
265:
181:. The derived cells migrate from the bone marrow to the
248:
and the fragment C3b of complement. They express LCAs (
224:
and immunophenotypical characteristics (demonstrated by
668:
650:
275:
511:
165:once they've reached the end of their lifespan.
1610:
482:
1225:
636:
1232:
1218:
643:
629:
577:
212:embeds this interpretation into its name.
601:
560:
467:
443:
402:
1239:
1150:Megakaryocyte–erythroid progenitor cell
1611:
367:A subset of cells differentiates into
288:. Phagocytosis is the main process of
1213:
624:
542:
449:
161:). Part of their job is to clear out
583:
240:. They bear membrane receptors for
420:haemophagocytic lymphohistiocytosis
362:
208:derivatives to be histiocytes. The
13:
603:10.1093/oxfordjournals.bmb.a011585
296:presentation the main property of
14:
1635:
236:and contains variable amounts of
173:Histiocytes are derived from the
371:; this maturation occurs in the
98:Anatomical terms of microanatomy
545:"Histiocytes and histiocytosis"
452:"Histiocytes and histiocytosis"
276:Macrophages and dendritic cells
536:
476:
416:Langerhans' cell histiocytosis
168:
1:
562:10.1182/blood.V84.9.2840.2840
469:10.1182/blood.V84.9.2840.2840
450:Cline, Mj (1 November 1994).
437:
210:Langerhans cell histiocytosis
191:mononuclear phagocytic system
841:Extramedullary hematopoiesis
391:(cells of the cortex of the
215:
124:mononuclear phagocyte system
7:
425:
10:
1640:
543:Cline MJ (November 1994).
1586:
1531:Hypersegmented neutrophil
1521:
1491:
1482:
1452:
1438:Hemoglobin precipitation
1404:
1378:
1368:Hereditary stomatocytosis
1314:Hereditary elliptocytosis
1283:
1257:
1248:
1174:
1134:
1108:
1080:
1047:
1007:Antigen-presenting cells
1000:
935:
926:
862:
853:
833:
795:
770:
761:
732:
692:
683:
659:
250:leucocyte common antigens
177:by multiplication from a
96:
84:
72:
60:
55:macrophagocytus immobilis
48:
43:
31:
26:
21:
1563:Critical green inclusion
1354:Sickle cell/drepanocyte
1326:Hereditary spherocytosis
1095:Nucleated red blood cell
651:Myeloid blood cells and
590:British Medical Bulletin
584:Webb DK (October 1996).
497:10.1016/j.it.2010.09.003
356:Human leukocyte antigens
220:Histiocytes have common
1295:Membrane abnormalities
1197:Hematopoietic stem cell
1116:Leukocyte extravasation
985:Foreign-body giant cell
1624:Mononuclear phagocytes
1465:Red cell agglutination
586:"Histiocyte disorders"
385:bronchiolar epithelium
204:Some sources consider
130:. The histiocyte is a
403:Clinical significance
1568:Alder–Reilly anomaly
1422:Basophilic stippling
1192:Hematopoietic system
980:Langhans giant cells
485:Trends in Immunology
286:antigen presentation
122:that is part of the
1543:Pelger–Huët anomaly
1501:Reactive lymphocyte
1427:Pappenheimer bodies
1358:Sickle cell disease
955:Alveolar macrophage
373:squamous epithelium
268:(also expressed by
1391:Hypochromic anemia
1126:Intrinsic immunity
990:Touton giant cells
331:contains numerous
196:However, the term
118:is a vertebrate
91:84642 83585, 84642
79:H2.00.03.0.01009
1606:
1605:
1602:
1601:
1558:Toxic vacuolation
1553:Toxic granulation
1484:White blood cells
1478:
1477:
1417:Howell–Jolly body
1207:
1206:
1170:
1169:
1043:
1042:
970:Epithelioid cells
849:
848:
829:
828:
825:
824:
757:
756:
519:"S12C3-Granuloma"
112:
111:
107:
1631:
1573:Jordans' anomaly
1489:
1488:
1406:Inclusion bodies
1255:
1254:
1234:
1227:
1220:
1211:
1210:
1141:Precursor cells
1067:Promegakaryocyte
933:
932:
860:
859:
785:Promegakaryocyte
768:
767:
690:
689:
681:
680:
666:
665:
645:
638:
631:
622:
621:
616:
615:
605:
581:
575:
574:
564:
540:
534:
533:
531:
530:
521:. Archived from
515:
509:
508:
480:
474:
473:
471:
462:(9): 2840–2853.
447:
397:Birbeck granules
369:Langerhans cells
363:Langerhans cells
333:acid phosphatase
145:, diminutive of
104:edit on Wikidata
101:
19:
18:
1639:
1638:
1634:
1633:
1632:
1630:
1629:
1628:
1609:
1608:
1607:
1598:
1582:
1517:
1474:
1448:
1400:
1374:
1279:
1250:Red blood cells
1244:
1238:
1208:
1203:
1166:
1130:
1109:Immune response
1104:
1082:Red blood cells
1076:
1039:
1016:Langerhans cell
1011:Dendritic cells
996:
922:
845:
821:
805:Proerythroblast
791:
753:
737:Monocytopoiesis
728:
672:
655:
649:
619:
582:
578:
541:
537:
528:
526:
517:
516:
512:
481:
477:
448:
444:
440:
428:
405:
365:
354:, and Class II
308:dendritic cells
298:dendritic cells
278:
218:
206:Langerhans cell
171:
108:
17:
16:Vertebrate cell
12:
11:
5:
1637:
1627:
1626:
1621:
1604:
1603:
1600:
1599:
1597:
1596:
1590:
1588:
1584:
1583:
1581:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1539:
1538:
1527:
1525:
1519:
1518:
1516:
1515:
1514:
1513:
1511:Russell bodies
1503:
1497:
1495:
1486:
1480:
1479:
1476:
1475:
1473:
1472:
1467:
1462:
1456:
1454:
1450:
1449:
1447:
1446:
1445:
1444:
1436:
1435:
1434:
1429:
1424:
1419:
1413:Developmental
1410:
1408:
1402:
1401:
1399:
1398:
1393:
1388:
1382:
1380:
1376:
1375:
1373:
1372:
1371:
1370:
1362:
1361:
1360:
1352:
1347:
1342:
1337:
1332:
1331:
1330:
1329:
1328:
1318:
1317:
1316:
1306:
1301:
1293:
1291:Poikilocytosis
1287:
1285:
1281:
1280:
1278:
1277:
1272:
1267:
1261:
1259:
1252:
1246:
1245:
1237:
1236:
1229:
1222:
1214:
1205:
1204:
1202:
1201:
1200:
1199:
1189:
1184:
1178:
1176:
1172:
1171:
1168:
1167:
1165:
1164:
1159:
1158:
1157:
1152:
1147:
1138:
1136:
1132:
1131:
1129:
1128:
1123:
1118:
1112:
1110:
1106:
1105:
1103:
1102:
1097:
1092:
1086:
1084:
1078:
1077:
1075:
1074:
1069:
1064:
1062:Megakaryoblast
1059:
1053:
1051:
1045:
1044:
1041:
1040:
1038:
1037:
1036:
1035:
1025:
1024:
1023:
1018:
1013:
1004:
1002:
998:
997:
995:
994:
993:
992:
987:
982:
972:
967:
962:
957:
952:
947:
941:
939:
930:
924:
923:
921:
920:
919:
918:
908:
907:
906:
896:
895:
894:
884:
879:
874:
868:
866:
857:
855:Myeloid tissue
851:
850:
847:
846:
844:
843:
837:
835:
831:
830:
827:
826:
823:
822:
820:
819:
818:
817:
812:
807:
800:Erythropoiesis
796:
793:
792:
790:
789:
788:
787:
782:
780:Megakaryoblast
775:Thrombopoiesis
771:
765:
759:
758:
755:
754:
752:
751:
750:
749:
744:
733:
730:
729:
727:
726:
725:
724:
719:
714:
709:
704:
697:Granulopoiesis
693:
687:
678:
663:
657:
656:
648:
647:
640:
633:
625:
618:
617:
576:
555:(9): 2840–53.
535:
510:
491:(12): 438–45.
475:
441:
439:
436:
435:
434:
427:
424:
404:
401:
364:
361:
360:
359:
344:
277:
274:
270:T helper cells
217:
214:
170:
167:
139:dendritic cell
110:
109:
100:
94:
93:
88:
82:
81:
76:
70:
69:
64:
58:
57:
52:
46:
45:
41:
40:
35:
29:
28:
24:
23:
15:
9:
6:
4:
3:
2:
1636:
1625:
1622:
1620:
1617:
1616:
1614:
1595:
1592:
1591:
1589:
1585:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1537:
1534:
1533:
1532:
1529:
1528:
1526:
1524:
1520:
1512:
1509:
1508:
1507:
1504:
1502:
1499:
1498:
1496:
1494:
1490:
1487:
1485:
1481:
1471:
1468:
1466:
1463:
1461:
1458:
1457:
1455:
1451:
1443:
1440:
1439:
1437:
1433:
1430:
1428:
1425:
1423:
1420:
1418:
1415:
1414:
1412:
1411:
1409:
1407:
1403:
1397:
1396:Polychromasia
1394:
1392:
1389:
1387:
1384:
1383:
1381:
1377:
1369:
1366:
1365:
1363:
1359:
1356:
1355:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1327:
1324:
1323:
1322:
1319:
1315:
1312:
1311:
1310:
1307:
1305:
1302:
1300:
1297:
1296:
1294:
1292:
1289:
1288:
1286:
1282:
1276:
1273:
1271:
1268:
1266:
1263:
1262:
1260:
1256:
1253:
1251:
1247:
1242:
1235:
1230:
1228:
1223:
1221:
1216:
1215:
1212:
1198:
1195:
1194:
1193:
1190:
1188:
1185:
1183:
1180:
1179:
1177:
1173:
1163:
1162:Myelomonocyte
1160:
1156:
1153:
1151:
1148:
1146:
1143:
1142:
1140:
1139:
1137:
1133:
1127:
1124:
1122:
1119:
1117:
1114:
1113:
1111:
1107:
1101:
1098:
1096:
1093:
1091:
1088:
1087:
1085:
1083:
1079:
1073:
1072:Megakaryocyte
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1054:
1052:
1050:
1046:
1034:
1031:
1030:
1029:
1026:
1022:
1019:
1017:
1014:
1012:
1009:
1008:
1006:
1005:
1003:
999:
991:
988:
986:
983:
981:
978:
977:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
950:Kupffer cells
948:
946:
943:
942:
940:
938:
934:
931:
929:
925:
917:
914:
913:
912:
909:
905:
902:
901:
900:
897:
893:
890:
889:
888:
885:
883:
880:
878:
875:
873:
870:
869:
867:
865:
861:
858:
856:
852:
842:
839:
838:
836:
832:
816:
813:
811:
808:
806:
803:
802:
801:
798:
797:
794:
786:
783:
781:
778:
777:
776:
773:
772:
769:
766:
764:
760:
748:
745:
743:
740:
739:
738:
735:
734:
731:
723:
720:
718:
717:Metamyelocyte
715:
713:
710:
708:
705:
703:
700:
699:
698:
695:
694:
691:
688:
686:
682:
679:
676:
671:
667:
664:
662:
661:Hematopoiesis
658:
654:
646:
641:
639:
634:
632:
627:
626:
623:
613:
609:
604:
599:
596:(4): 818–25.
595:
591:
587:
580:
572:
568:
563:
558:
554:
550:
546:
539:
525:on 2009-09-29
524:
520:
514:
506:
502:
498:
494:
490:
486:
479:
470:
465:
461:
457:
453:
446:
442:
433:
432:Histiocytosis
430:
429:
423:
421:
417:
413:
409:
408:Histiocytoses
400:
398:
394:
390:
386:
382:
378:
374:
370:
357:
353:
349:
345:
342:
338:
334:
330:
326:
325:
324:
322:
318:
314:
309:
305:
301:
299:
295:
291:
287:
283:
273:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
213:
211:
207:
202:
199:
194:
192:
188:
184:
180:
176:
166:
164:
160:
156:
152:
148:
144:
140:
136:
133:
129:
128:immune system
125:
121:
117:
105:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
68:
65:
63:
59:
56:
53:
51:
47:
42:
39:
38:Immune system
36:
34:
30:
25:
20:
1619:Cell biology
1548:Döhle bodies
1536:Arneth count
1523:Granulocytes
1386:Anisochromia
1364:Stomatocyte
1275:Microcytosis
1270:Macrocytosis
1265:Anisocytosis
1121:Phagocytosis
1090:Reticulocyte
944:
864:Granulocytes
815:Reticulocyte
707:Promyelocyte
670:Myelopoiesis
593:
589:
579:
552:
548:
538:
527:. Retrieved
523:the original
513:
488:
484:
478:
459:
455:
445:
406:
366:
348:Factor XIIIa
323:, and size.
302:
282:phagocytosis
279:
234:eosinophilic
226:immunostains
222:histological
219:
203:
197:
195:
172:
158:
154:
150:
146:
142:
115:
113:
54:
1506:Smudge cell
1493:Lymphocytes
1432:Cabot rings
1345:Schistocyte
1309:Elliptocyte
1299:Acanthocyte
975:giant cells
965:Osteoclasts
945:Histiocytes
937:Macrophages
747:Promonocyte
377:lymph nodes
304:Macrophages
290:macrophages
175:bone marrow
169:Development
163:neutrophils
44:Identifiers
1613:Categories
1578:Left shift
1460:Haemoconia
1442:Heinz body
1340:Echinocyte
1321:Spherocyte
1241:Blood film
899:Eosinophil
882:Neutrophil
872:Myeloblast
810:Normoblast
702:Myeloblast
529:2009-01-06
438:References
412:neoplasias
389:thymocytes
317:morphology
244:, such as
228:). Their
198:histiocyte
157:, meaning
149:, meaning
135:macrophage
116:histiocyte
22:Histiocyte
1350:Degmacyte
1335:Dacrocyte
1182:Phagocyte
1049:Platelets
1028:Monoblast
960:Microglia
928:Monocytes
911:Mast cell
877:Band cell
742:Monoblast
722:Band cell
712:Myelocyte
410:describe
337:lysosomes
329:cytoplasm
321:phenotype
238:lysosomes
230:cytoplasm
216:Structure
187:monocytes
179:stem cell
1594:Auer rod
1470:Rouleaux
1304:Codocyte
1243:findings
1155:CFU-GEMM
916:CFU-Mast
892:CFU-Baso
887:Basophil
675:CFU-GEMM
505:21030305
426:See also
242:opsonins
1057:CFU-Meg
904:CFU-Eos
834:General
612:9039734
571:7524755
294:antigen
193:(MPS).
67:D006644
27:Details
1379:Colour
1187:Plasma
1145:CFU-GM
1021:CFU-DL
685:CFU-GM
653:plasma
610:
569:
503:
393:thymus
383:, and
381:spleen
335:laden
264:, and
153:, and
151:tissue
143:histio
132:tissue
33:System
1587:Other
1453:Other
1284:Shape
1175:Other
1135:Other
1100:CFU-E
1001:Other
549:Blood
456:Blood
183:blood
147:histo
137:or a
102:[
50:Latin
1258:Size
608:PMID
567:PMID
501:PMID
418:and
352:CD1c
341:CD68
306:and
292:and
284:and
262:CD33
258:CD14
254:CD45
159:cell
155:cyte
120:cell
62:MeSH
1033:MPS
763:MEP
598:doi
557:doi
493:doi
464:doi
313:TNF
272:).
266:CD4
246:IgG
232:is
185:as
86:FMA
1615::
606:.
594:52
592:.
588:.
565:.
553:84
551:.
547:.
499:.
489:31
487:.
460:84
458:.
454:.
422:.
399:.
379:,
375:,
350:,
319:,
260:,
256:,
252:)
114:A
74:TH
1233:e
1226:t
1219:v
677:)
673:(
644:e
637:t
630:v
614:.
600::
573:.
559::
532:.
507:.
495::
472:.
466::
358:.
343:.
141:(
106:]
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