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hemostats are topical agents composed of chitosan and its salts. Chitosan bonds with platelets and red blood cells to form a gel-like clot which seals a bleeding vessel. Unlike other hemostat technologies its action does not require the normal hemostatic pathway and therefore continues to function
160:
hemostat (MCH) is a topical agent composed of resorbable microfibrillar collagen. It attracts platelets and allows for the formation of a blood clot when it comes into contact with blood. Unlike the hemostatic clamp, no mechanical action is involved. The surgeon presses the MCH against a bleeding
93:
Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis,
286:
were invented, a styptic pencil was a standard part of a shaving kit and was used to seal shaving cuts. Some people continue to use styptic pencils for minor skin wounds from safety or electric razors.
362:
675:
345:
568:"Chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation"
623:
94:
better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time.
179:
Chitosan is used in some emergency hemostats which are designed to stop traumatic life-threatening bleeding. Their use is well established in many military and trauma units.
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652:
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is the main ingredient and acts as a vasoconstrictor in order to disable blood flow. The stick is applied directly to the bleeding site. The high
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631:
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721:
1985:
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in it) activate the coagulation cascade, and have been used as the active component of hemostatic dressings (for example, in
1845:
1838:
680:
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1588:
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trade to stop bleeding from nails that are clipped too closely. This powder is generally used on animals, such as
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1741:
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139:. They are available in three forms—as a granular powder poured on wounds, as a styptic pencil or embedded in a
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site, and the collagen attracts and helps with the clotting process to eventually stop bleeding.
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A common delivery system for this is a styptic or hemostatic pencil (not to be confused with a
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There are several classes of antihemorrhagic drugs used in medicine. These include
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The practical application for MCH is different from that of the hemostatic clamp.
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of the blood, and the astringent chemical causes local vasoconstriction. Before
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Antihemorrhagic agents used in medicine have various mechanisms of action:
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244:) is a specific type of antihemorrhagic agent that works by contracting
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624:"Military Experts Say Newer Hemostatic Dressings Beat Gauze // ACEP"
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2011:
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Topical hemostatic agents have been gaining popularity for use in
2123:
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566:
Millner, Russell; Lockhart, Alan S; Marr, Rebecca (2010-10-01).
1805:
1468:
1138:
303:
198:
217:
2105:
1815:
1310:
697:"Styptic Pencil what is it, how to use at Executive Shaving"
1809:
229:
382:"Comparison of hemostatic agents used in vascular surgery"
431:
Pharmacology ReCap 2.0 for
Bachelor of Dentistry Students
299:
295:
485:
Sundaram, Chandru P.; Keenan, Alison C. (2010-01-01).
1215:
699:. Executive-shaving.co.uk. 2015-08-21. Archived from
487:"Evolution of hemostatic agents in surgical practice"
653:"HOW QUIKCLOT BRAND PRODUCTS WORK TO STOP BLEEDING"
565:
547:
Film forming personal care compositions and methods
176:even when anticoagulants like heparin are present.
572:Annals of the Royal College of Surgeons of England
380:Vyas, Krishna S; Saha, Sibu P (22 October 2013).
306:, whose vein is found in the center of the nail.
76:Locally acting hemostatic agents work by causing
2220:
484:
1198:
762:
1213:Major chemical drug groups – based upon the
1205:
1191:
776:
769:
755:
151:
1082:Tetragalacturonic acid hydroxymethylester
599:
520:
502:
405:
379:
224:
216:
691:
689:
14:
2221:
2192:Pharmacological classification systems
1559:Selective estrogen receptor modulators
658:. Z-Medica Corporation. Archived from
457:"When to use hemostatic agents in EMS"
1839:Non-steroidal anti-inflammatory drugs
1186:
750:
187:
42:) agent is a substance that promotes
686:
543:
386:Expert Opinion on Biological Therapy
1452:Angiotensin II receptor antagonists
24:
65:Systemic drugs work by inhibiting
25:
2250:
957:(II, VII, IX, X, protein C and S)
2201:
2181:
2180:
584:10.1308/003588410X12699663903593
1589:Hypothalamic–pituitary hormones
1000:thrombopoietin receptor agonist
955:Prothrombin complex concentrate
714:
669:
645:
616:
544:Dong, Shaosheng (Nov 6, 2014),
434:. Quick Review of Pharmacology.
88:
1092:Hemostatic Powder Spray TC-325
559:
537:
478:
449:
438:
422:
373:
356:
339:
327:Hemostatic Powder Spray TC-325
290:Styptic powder is used in the
13:
1:
1341:Thrombolytics / fibrinolytics
332:
50:). It may also be known as a
27:Substance that stops bleeding
2052:Wakefulness-promoting agents
722:"Pet first-aid kit contents"
681:Dorland's Medical Dictionary
398:10.1517/14712598.2013.848193
368:Dorland's Medical Dictionary
351:Dorland's Medical Dictionary
263:). This is a short stick of
182:
39:
7:
445:Styptic Pencil (definition)
309:
212:
167:
102:
10:
2255:
1702:Intravenous immunoglobulin
887:Valoctocogene roxaparvovec
252:. Styptic pencils contain
194:contact activation pathway
191:
146:
133:emergency bleeding control
2176:
2132:
2104:
2060:
1869:
1804:
1767:
1715:
1628:
1572:
1532:
1489:
1373:
1309:
1221:
1104:
1048:Absorbable gelatin sponge
1040:
964:
842:
811:
804:
789:
491:Indian Journal of Urology
1757:Topoisomerase inhibitors
1441:renin–angiotensin system
1435:Calcium channel blockers
897:Fidanacogene elaparvovec
126:
97:
1131:Aminomethylbenzoic acid
504:10.4103/0970-1591.70574
152:Microfibrillar collagen
1549:Hormonal contraception
1479:Bile acid sequestrants
1260:Proton-pump inhibitors
1223:gastrointestinal tract
233:
222:
863:Damoctocog alfa pegol
665:on 23 September 2014.
228:
220:
2239:Transfusion medicine
2158:Radiopharmaceuticals
1946:Antiparkinson agents
82:platelet aggregation
1941:Antimigraine agents
1931:Antidementia agents
1834:Anti-inflammatories
1524:Medicated dressings
1464:Antihyperlipidemics
1291:Diabetes medication
726:www.vet.cornell.edu
113:coagulation factors
1794:Immunosuppressants
1664:Antimycobacterials
1620:Antithyroid agents
1604:Mineralocorticoids
1408:Cardiac stimulants
1398:Cardiac glycosides
1390:cardiac therapy /
1286:Anti-obesity drugs
1077:Oxidized cellulose
867:Efanesoctocog alfa
318:– Antihemorrhagics
234:
223:
188:Contact activation
2216:
2215:
2119:Ophthalmologicals
1829:Anabolic steroids
1732:Anticancer agents
1695:Ectoparasiticides
1415:Antihypertensives
1363:Antifibrinolytics
1180:
1179:
1150:Alfa1 antitrypsin
1121:Aminocaproic acid
1106:Antifibrinolytics
1100:
1099:
1036:
1035:
871:Efmoroctocog alfa
821:Phytomenadione (K
392:(12): 1663–1672.
346:"antihemorrhagic"
272:aluminium sulfate
137:military medicine
109:antifibrinolytics
16:(Redirected from
2246:
2229:Antihemorrhagics
2205:
2184:
2183:
2168:Senotherapeutics
2022:Neuroprotectives
2017:Mood stabilizers
1916:Anti-ADHD agents
1856:Muscle relaxants
1789:Immunostimulants
1784:Immunomodulators
1616:Thyroid hormones
1554:Fertility agents
1457:Renin inhibitors
1348:Antihemorrhagics
1315:forming organs (
1301:Dietary minerals
1207:
1200:
1193:
1184:
1183:
1053:Calcium alginate
809:
808:
802:
801:
791:Antihemorrhagics
778:Antihemorrhagics
771:
764:
757:
748:
747:
741:
740:
738:
737:
728:. Archived from
718:
712:
711:
709:
708:
693:
684:
673:
667:
666:
664:
657:
649:
643:
642:
640:
639:
630:. Archived from
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563:
557:
556:
555:
554:
541:
535:
534:
524:
506:
482:
476:
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472:
463:. Archived from
453:
447:
442:
436:
435:
426:
420:
419:
409:
377:
371:
360:
354:
343:
322:Hemostatic clamp
248:to seal injured
135:, especially in
78:vasoconstriction
41:
40:antihaemorrhagic
21:
18:Hemostatic agent
2254:
2253:
2249:
2248:
2247:
2245:
2244:
2243:
2219:
2218:
2217:
2212:
2208:Medicine portal
2172:
2128:
2100:
2095:
2087:Cough medicines
2082:Bronchodilators
2063:
2056:
1936:Antidepressants
1926:Anticonvulsants
1874:
1865:
1861:Bisphosphonates
1851:Corticosteroids
1813:
1800:
1772:
1763:
1747:Spindle poisons
1737:Antimetabolites
1720:
1711:
1633:
1624:
1599:Glucocorticoids
1594:Corticosteroids
1575:
1568:
1535:
1528:
1485:
1403:Antiarrhythmics
1376:
1369:
1326:Antithrombotics
1314:
1305:
1281:Antipropulsives
1277:Antidiarrhoeals
1254:
1225:
1217:
1211:
1181:
1176:
1126:Tranexamic acid
1096:
1032:
966:
960:
883:Turoctocog alfa
879:Susoctocog alfa
875:Moroctocog alfa
845:
838:
833:
824:
793:
785:
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733:
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719:
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483:
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378:
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344:
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232:block and razor
215:
196:
190:
185:
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156:Microfibrillar
154:
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129:
105:
100:
91:
36:British English
32:antihemorrhagic
28:
23:
22:
15:
12:
11:
5:
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2210:
2199:
2194:
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2153:Contrast media
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2106:sensory organs
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2019:
2014:
2005:
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2003:
1998:
1993:
1983:
1978:
1973:
1968:
1963:
1958:
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1951:Antipsychotics
1948:
1943:
1938:
1933:
1928:
1923:
1921:Antiaddictives
1918:
1913:
1908:
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1906:
1901:
1891:
1885:
1883:
1876:nervous system
1867:
1866:
1864:
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1858:
1853:
1848:
1846:Antirheumatics
1843:
1842:
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1796:
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1752:Antineoplastic
1749:
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1713:
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1685:Antiprotozoals
1680:Antiparasitics
1677:
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1660:Antibacterials
1656:Antimicrobials
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1519:Antipsoriatics
1516:
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1461:
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1449:
1447:ACE inhibitors
1437:
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1410:
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1386:
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1375:cardiovascular
1371:
1370:
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1336:Anticoagulants
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1008:
996:
991:
986:
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947:
938:
933:
928:
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850:
848:
840:
839:
837:
836:
831:
827:
822:
817:
815:
806:
799:
787:
786:
774:
773:
766:
759:
751:
743:
742:
713:
685:
668:
644:
615:
578:(7): 559–561.
558:
536:
497:(3): 374–378.
477:
448:
437:
421:
372:
355:
337:
336:
334:
331:
330:
329:
324:
319:
311:
308:
276:ionic strength
261:caustic pencil
240:(also spelled
221:Styptic pencil
214:
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153:
150:
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128:
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54:(also spelled
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9:
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4:
3:
2:
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2240:
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2227:
2226:
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2209:
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2107:
2103:
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2077:Decongestants
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2018:
2015:
2013:
2009:
2006:
2002:
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1996:Dissociatives
1994:
1992:
1989:
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1986:Hallucinogens
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1982:
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1727:
1724:
1718:
1714:
1708:
1705:
1703:
1700:
1696:
1693:
1691:
1690:Anthelmintics
1688:
1686:
1683:
1682:
1681:
1678:
1676:
1673:
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1541:
1537:
1534:genitourinary
1531:
1525:
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1514:Antipruritics
1512:
1510:
1507:
1505:
1502:
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1499:
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1477:
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1331:Antiplatelets
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1026:Rafutrombopag
1024:
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1021:Lusutrombopag
1019:
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1009:
1007:
1004:
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1002:
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980:
979:Carbazochrome
977:
975:
972:
971:
969:
963:
956:
953:
952:combinations:
950:
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946:
942:
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702:
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672:
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654:
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634:on 2016-03-15
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467:on 2016-03-15
466:
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281:
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250:blood vessels
247:
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210:
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79:
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69:or promoting
68:
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59:
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53:
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45:
37:
33:
19:
1991:Psychedelics
1961:Aphrodisiacs
1635:infestations
1611:Sex hormones
1564:Sex hormones
1509:Cicatrizants
1439:
1425:Vasodilators
1392:antianginals
1389:
1347:
1241:stomach acid
1240:
1155:C1-inhibitor
1137:
1113:
1011:Avatrombopag
998:
994:Fostamatinib
951:
945:Catridecacog
936:I/Fibrinogen
922:
916:Eptacog alfa
908:
901:Nonacog alfa
853:
830:Menadione (K
790:
777:
734:. Retrieved
730:the original
725:
716:
705:. Retrieved
701:the original
679:
676:"astringent"
671:
660:the original
647:
636:. Retrieved
632:the original
628:www.acep.org
627:
618:
575:
571:
561:
551:, retrieved
546:
539:
494:
490:
480:
469:. Retrieved
465:the original
460:
451:
440:
430:
424:
389:
385:
375:
366:
358:
349:
341:
316:ATC code B02
289:
280:flocculation
258:
241:
237:
235:
197:
178:
171:
163:
155:
130:
106:
92:
89:Medical uses
67:fibrinolysis
60:
55:
51:
31:
29:
2124:Otologicals
2096:antagonists
2062:respiratory
2037:Orexigenics
2032:Neurotoxins
1981:Euphoriants
1971:Entactogens
1966:Depressants
1956:Anxiolytics
1894:Anesthetics
1670:Antifungals
1267:Antiemetics
1255:antagonists
1170:Ulinastatin
1115:amino acids
1072:Fibrin glue
1063:Epinephrine
1016:Eltrombopag
1006:Romiplostim
931:II/Thrombin
844:Coagulation
796:coagulation
254:astringents
71:coagulation
56:haemostatic
2223:Categories
2047:Stimulants
2027:Nootropics
2001:Deliriants
1976:Entheogens
1911:Anorectics
1889:Analgesics
1742:Alkylating
1675:Antivirals
1630:infections
1504:Emollients
1358:Coagulants
1228:metabolism
1067:adrenalone
989:Etamsylate
984:Concizumab
974:Batroxobin
909:extrinsic:
854:intrinsic:
736:2016-03-14
707:2015-10-20
638:2016-03-14
553:2016-03-14
471:2016-03-14
363:"hemostat"
333:References
292:veterinary
265:medication
192:See also:
117:fibrinogen
52:hemostatic
44:hemostasis
2197:ATC codes
2163:Dressings
2148:Antidotes
2012:Sedatives
2008:Hypnotics
1717:malignant
1574:endocrine
1420:Diuretics
1353:Platelets
1313:and blood
1272:Laxatives
1166:unsorted
1145:Aprotinin
813:Vitamin K
592:0035-8843
513:0970-1591
278:promotes
269:Anhydrous
201:(and the
183:Inorganic
121:vitamin K
58:) agent.
2042:Serenics
1707:Vaccines
1474:Fibrates
1296:Vitamins
1246:Antacids
1160:Camostat
1087:Thrombin
1058:Collagen
967:systemic
805:Systemic
610:20522310
531:21116358
416:24144261
310:See also
213:Styptics
207:QuikClot
173:Chitosan
168:Chitosan
158:collagen
141:dressing
111:, blood
103:Systemic
48:bleeding
2234:Shaving
1899:General
1806:muscles
1775:L03–L04
1771:disease
1723:L01–L02
1719:disease
1469:Statins
1139:serpins
923:common:
846:factors
601:3229344
522:2978438
407:4390172
304:rabbits
242:stiptic
238:styptic
203:zeolite
147:Organic
46:(stops
2206:
2185:
2133:other
2064:system
1816:joints
1769:immune
1576:system
1536:system
1377:system
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511:
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302:, and
246:tissue
199:Kaolin
119:, and
2187:Drugs
1904:Local
1871:brain
1810:bones
1311:blood
1041:Local
965:Other
663:(PDF)
656:(PDF)
127:Local
98:Types
1814:and
1491:skin
941:XIII
859:VIII
606:PMID
588:ISSN
527:PMID
509:ISSN
461:EMS1
412:PMID
300:dogs
296:cats
230:Alum
2135:ATC
1873:and
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