442:'s GMP (EU GMP) enforces similar requirements to WHO GMP, as does the FDA's version in the US. Similar GMPs are used in other countries, with Australia, Canada, Japan, Saudi Arabia, Singapore, Philippines], Vietnam and others having highly developed/sophisticated GMP requirements. In the United Kingdom, the Medicines Act (1968) covers most aspects of GMP in what is commonly referred to as "The Orange Guide," which is named so because of the color of its cover; it is officially known as
2612:
31:
2636:
2624:
398:
non-governmental organizations such as the
International Society for Pharmaceutical Engineering (ISPE) and the Parenteral Drug Association (PDA) have developed information and resources to help pharmaceutical companies better understand why quality culture is important and how to assess the current situation within a site or organization.
380:
Good manufacturing practices are recommended with the goal of safeguarding the health of consumers and patients as well as producing quality products. In the United States, a food or drug may be deemed "adulterated" if it has passed all of the specifications tests but is found to be manufactured in a
323:
Good manufacturing practice guidelines provide guidance for manufacturing, testing, and quality assurance in order to ensure that a manufactured product is safe for human consumption or use. Many countries have legislated that manufacturers follow GMP procedures and create their own GMP guidelines
295:
The rules that govern each industry may differ significantly; however, the main purpose of GMP is always to prevent harm from occurring to the end user. Additional tenets include ensuring the end product is free from contamination, that it is consistent in its manufacture, that its manufacture has
397:
is an organizational core value and employees are encouraged to identify and promptly report data integrity issues.” Australia's
Therapeutic Goods Administration has said that recent data integrity failures have raised questions about the role of quality culture in driving behaviors. In addition,
388:
Regulatory agencies have recently begun to look at more fundamental quality metrics of manufacturers than just compliance with basic GMP regulations. US-FDA has found that manufacturers who have implemented quality metrics programs gain a deeper insight into employee behaviors that impact
384:
GMP standards are not prescriptive instructions on how to manufacture products. They are a series of performance based requirements that must be met during manufacturing. When a company is setting up its quality program and manufacturing process, there may be many ways it can fulfill GMP
507:
Regulatory agencies (including the FDA in the U.S. and regulatory agencies in many
European nations) are authorized to conduct unannounced inspections, though some are scheduled. FDA routine domestic inspections are usually unannounced, but must be conducted according to 704(a) of the
454:
363:
Records must be made, manually or electronically, during manufacture that demonstrate that all the steps required by the defined procedures and instructions were in fact taken and that the quantity and quality of the food or drug was as expected. Deviations must be investigated and
457:(ICH), GMPs now apply in those countries and trade groupings that are signatories to ICH (the EU, Japan and the U.S.), and applies in other countries (e.g., Australia, Canada, Singapore) which adopt ICH guidelines for the manufacture and testing of active raw materials.
418:
even if there is no specific regulatory requirement that was violated as long as the process was not performed according to industry standards. However, since June 2007, a different set of CGMP requirements have applied to all manufacturers of
498:
carries out routine GMP inspections to ensure that drug products are produced safely and correctly. Additionally, many countries perform pre-approval inspections (PAI) for GMP compliance prior to the approval of a new drug for marketing.
465:
Within the
European Union GMP inspections are performed by National Regulatory Agencies. GMP inspections are performed in Canada by the Health Products and Food Branch Inspectorate; in the United Kingdom by the
392:
In its
Guidance for Industry "Data Integrity and Compliance With Drug CGMP" US-FDA states “it is the role of management with executive responsibility to create a quality culture where employees understand that
2422:
376:
Complaints about marketed products must be examined, the causes of quality defects must be investigated, and appropriate measures must be taken with respect to the defective products and to prevent recurrence.
423:, with additional supporting guidance issued in 2010. Additionally, in the U.S., medical device manufacturers must follow what are called "quality system regulations" which are deliberately harmonized with
296:
been well documented, that personnel are well trained, and that the product has been checked for quality more than just at the end phase. GMP is typically ensured through the effective use of a
1283:
292:. These guidelines provide minimum requirements that a manufacturer must meet to assure that their products are consistently high in quality, from batch to batch, for their intended use.
1340:
512:(21 USCS § 374), which requires that they are performed at a "reasonable time". Courts have held that any time the firm is open for business is a reasonable time for an inspection.
849:
747:"Guidance for Industry: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements; Small Entity Compliance Guide"
350:
Manufacturing processes must be controlled, and any changes to the process must be evaluated. Changes that affect the quality of the drug are validated as necessary.
367:
Records of manufacture (including distribution) that enable the complete history of a batch to be traced must be retained in a comprehensible and accessible form.
1119:
268:) are those conforming to the guidelines recommended by relevant agencies. Those agencies control the authorization and licensing of the manufacture and sale of
1438:
385:
requirements. It is the company's responsibility to determine the most effective and efficient quality process that both meets business and regulatory needs.
414:. The regulations use the phrase "current good manufacturing practices" (CGMP) to describe these guidelines. Courts may theoretically hold that a product is
467:
1312:"Updated list of WHO GMP Certified Manufacturing Units for Certificate of Pharmaceutical Products (COPP) in various States of India as on December 2016"
478:(TGA); in Bangladesh by the Directorate General of Drug Administration (DGDA); in South Africa by the Medicines Control Council (MCC); in Brazil by the
2417:
890:
62:
746:
2407:
1014:
992:
315:, are overseen by regulatory agencies in the United Kingdom, United States, Canada, various European countries, China, India and other countries.
424:
1351:
1379:
483:
56:
768:
Ramakrishna, S.; Tian, L.; Wang, C.; et al., eds. (2015). "Chapter 3.: Quality management systems for medical device manufacture".
2457:
1311:
580:" requirements, all of which follow similar philosophies. Other examples include good guidance practices, and good tissue practices.
801:
Quality
Assurance of Pharmaceuticals: A compendium of guidelines and related materials - Good manufacturing practices and inspection
915:
2490:
2462:
1502:
1230:"Assessment of the Good Manufacturing Practices Inspection Program of the Bangladesh Directorate General of Drug Administration"
2467:
1783:
1229:
2525:
2432:
610:
487:
248:
2515:
509:
2472:
2036:
1624:
1146:
479:
1540:
2530:
2056:
1639:
1077:
808:
779:
727:
697:
657:
2672:
1175:
945:
594:
475:
471:
2687:
2677:
2173:
1801:
1778:
1406:"Guidance for Industry Circumstances that Constitute Delaying, Denying, Limiting, or Refusing a Drug Inspection"
2628:
2447:
2397:
2209:
2106:
1867:
1768:
1681:
1448:
1405:
2640:
2280:
2051:
344:
2667:
2145:
1872:
888:
407:
891:"Presentation: Driving a GMP / Quality Culture to provide supporting evidence of better business outcomes"
572:
Good regulatory practice (GRP), for the management of regulatory commitments, procedures and documentation
2185:
2096:
1909:
1897:
1806:
1495:
354:
2362:
2287:
2192:
1728:
524:
304:
1036:
2484:
2479:
2347:
2046:
1753:
1711:
1675:
1582:
1258:
431:
297:
241:
2322:
2021:
1733:
1629:
551:
381:
facility or condition which violates or does not comply with current good manufacturing guideline.
308:
2593:
2520:
2352:
435:
2682:
2616:
2588:
2367:
2091:
1577:
1488:
1475:
967:
530:
340:
from adulterants and allergens that may render the product unsafe for human consumption or use.
336:
Manufacturing facilities must maintain controlled environmental conditions in order to prevent
312:
68:
1383:
1203:
1097:
2573:
2357:
1892:
1793:
1686:
1535:
796:
685:
207:
115:
1315:
1065:
2662:
2548:
2332:
2197:
2163:
2111:
1936:
1931:
1877:
1833:
1723:
1661:
1550:
1545:
850:"Frequently Asked Questions regarding the Quality Metrics Site Visit and Feedback Programs"
343:
Manufacturing processes must be clearly defined and controlled. All critical processes are
234:
1443:
916:"ISPE – PDA Guide to Improving Quality Culture in Pharmaceutical Manufacturing Facilities"
889:
Australian
Government Department of Health Therapeutic Goods Administration (2018-08-09).
865:"Data Integrity and Compliance With Drug CGMP Questions and Answers Guidance for Industry"
797:"Chapter 1: WHO good manufacturing practices: Main principles for pharmaceutical products"
686:"Chapter 5: Manufacturing Cosmetic Ingredients According to Good Manufacturing Principles"
8:
2558:
2553:
2327:
2126:
2116:
1951:
1560:
1468:
1464:
1460:
1456:
1452:
2180:
1763:
1612:
774:. Woodhead Publishing Series in Biomaterials. Vol. 103. Elsevier. pp. 49–64.
420:
285:
2342:
2337:
2265:
2214:
1988:
1968:
1956:
1916:
1887:
1855:
1773:
1666:
1634:
1530:
1073:
1037:"US CFR Title 21 §210.1(b) Status of current good manufacturing practice regulations"
804:
775:
723:
693:
653:
545:
45:
1433:
649:
Food and Drink - Good
Manufacturing Practice - A Guide to its responsible management
353:
Instructions and procedures must be written in clear and unambiguous language using
2507:
2260:
2219:
2031:
2006:
1818:
1748:
1592:
1233:
1144:
616:
482:(ANVISA); in India by state Food and Drugs Administrations (FDA), reporting to the
122:
2568:
2270:
2073:
2066:
2001:
1941:
1823:
1813:
1743:
1716:
1701:
1656:
1646:
1597:
769:
717:
647:
200:
143:
2255:
2041:
1978:
1963:
1946:
1904:
1706:
1587:
1095:
555:
439:
394:
333:
Manufacturing facilities must maintain a clean and hygienic manufacturing area.
289:
273:
94:
1382:. National Agency for Food and Drug Administration and Control. Archived from
2656:
2563:
2442:
2250:
2224:
2101:
2061:
2026:
2016:
1996:
1738:
1696:
1671:
1619:
1607:
1602:
1511:
589:
576:
Collectively, these and other good-practice requirements are referred to as "
337:
269:
993:"Quality System (QS) Regulation/Medical Device Good Manufacturing Practices"
864:
824:
2583:
2011:
1860:
1850:
1828:
1758:
1651:
1565:
1314:. Central Drugs Standard Control Organization. 10 June 2017. Archived from
1227:
1206:. Department of Health, Therapeutic Goods Administration. 29 September 2017
1098:"Rules and Guidance for Pharmaceutical Manufacturers and Distributors 2017"
563:
495:
645:
544:
Good distribution practice (GDP) deals with the guidelines for the proper
2578:
2275:
1973:
1882:
1845:
605:
415:
221:
173:
168:
150:
22:
438:
in over 100 countries worldwide, primarily in the developing world. The
2204:
1926:
1145:
Medicines and
Healthcare products Regulatory Agency (20 October 2017).
847:
767:
569:
Good pharmacovigilance practice (GVP), for the safety of produced drugs
559:
281:
136:
373:
A system must be in place for recalling any batch from sale or supply.
2302:
2121:
1691:
1572:
538:
370:
Any distribution of products must minimize any risk to their quality.
277:
183:
178:
1259:"Guide to Good Manufacturing Practice for Medicines in South Africa"
1015:"Draft Guidance for Industry: Cosmetic Good Manufacturing Practices"
444:
Rules and
Guidance for Pharmaceutical Manufacturers and Distributors
2168:
1921:
1555:
1525:
621:
600:
534:
129:
692:. Vol. 2. Norwich, New York: William Andrew. pp. 79–92.
434:(WHO) version of GMP is used by pharmaceutical regulators and the
1840:
803:. Vol. 2 (2nd updated ed.). WHO Press. pp. 17–18.
520:
Other good-practice systems, along the same lines as GMP, exist:
214:
84:
1480:
1173:
30:
2135:
862:
494:; and by similar national organizations worldwide. Each of the
491:
411:
360:
Operators must be trained to carry out and document procedures.
1228:
Anisfeld, M.H.; Kim, E.M.; Aimiuwu, J.; Thumm, M. (May 2015).
1063:
946:"Facts About the Current Good Manufacturing Practices (CGMPs)"
2297:
1147:"Good manufacturing practice and good distribution practice"
1059:
1057:
2423:
Committee on the Environment, Public Health and Food Safety
2229:
1054:
794:
749:. U.S. Food and Drug and Administration. 12 November 2017
577:
347:
to ensure consistency and compliance with specifications.
1434:
Pharmaceutical Inspection Cooperation Scheme: GMP Guides
1350:. Government of Pakistan. 9 October 2017. Archived from
1181:. National Institute of Food and Drug Safety Evaluation
89:
848:
Center for Drug Evaluation and Research (2019-12-20).
825:"Performance-Based Safety Regulation | Policy Studies"
679:
677:
675:
673:
671:
669:
470:(MHRA); in the Republic of Korea (South Korea) by the
1096:
Medicines and Healthcare products Regulatory Agency.
970:. U.S. Food and Drug Administration. 27 December 2017
771:
Medical Devices: Regulations, Standards and Practices
1017:. U.S. Food and Drug Administration. 3 November 2017
995:. U.S. Food and Drug Administration. 2 February 2018
923:
International Society for Pharmaceutical Engineering
1223:
1221:
948:. U.S. Food and Drug Administration. 6 October 2017
761:
666:
646:Institute of Food Science & Technology (2013).
468:
Medicines and Healthcare products Regulatory Agency
406:GMPs are enforced in the United States by the U.S.
690:Global Regulatory Issues for the Cosmetic Industry
541:conducting clinical studies on new drugs in humans
63:Hazard analysis and risk-based preventive controls
1411:. U.S. Food and Drug Administration. October 2014
1306:
1304:
1284:"Draft Technical Resolution nÂş 42, May 13th 2015"
1070:International Pharmaceutical Product Registration
741:
739:
2654:
1218:
1169:
1167:
1091:
1089:
987:
985:
719:Good Manufacturing Practices for Pharmaceuticals
546:distribution of medicinal products for human use
1174:Ministry of Food and Drug Safety (April 2017).
1064:Cartwright, A.C.; Matthews, B.R., eds. (2010).
1007:
940:
938:
1301:
1198:
1196:
968:"Current Good Manufacturing Practices (CGMPs)"
736:
1496:
1461:212 (GMP, positron emission tomography drugs)
1398:
1374:
1372:
1276:
1164:
1086:
982:
711:
709:
328:All guidelines follow a few basic principles:
242:
1335:
1333:
935:
641:
639:
637:
1232:. World Health Organization. Archived from
1204:"Good manufacturing practice - an overview"
1193:
960:
788:
715:
484:Central Drugs Standard Control Organization
57:Hazard analysis and critical control points
2458:Centers for Disease Control and Prevention
1503:
1489:
1369:
1253:
1251:
1138:
1072:(2nd ed.). CRC Press. pp. vi–x.
706:
451:GMPs for Active Pharmaceutical Ingredients
249:
235:
2418:Centre for Disease Prevention and Control
2408:Center for Disease Control and Prevention
1330:
913:
634:
455:International Conference on Harmonization
303:Good manufacturing practices, along with
1439:World Health Organization GMP Guidelines
1264:. Medicines Control Council. August 2010
1176:"Guide to Drug Approval System in Korea"
1126:. Government of Canada. 27 February 2015
863:US Food and Drug Administration (2018).
722:(6th ed.). CRC Press. p. 424.
324:that correspond with their legislation.
2463:Health departments in the United States
1289:. World Trade Organization. 13 May 2015
1248:
554:(GLP), for laboratories conducting non-
515:
2655:
2468:Council on Education for Public Health
1112:
1041:Electronic Code of Federal Regulations
895:Therapeutic Goods Administration (TGA)
2526:Professional degrees of public health
2433:Ministry of Health and Family Welfare
1484:
1474:Report on Optimizing and Leaning GMP
683:
613:(GAMP) in the pharmaceutical industry
611:Good automated manufacturing practice
488:Drug Regulatory Authority of Pakistan
427:requirements, not necessarily CGMPs.
401:
318:
2623:
2516:Bachelor of Science in Public Health
1469:226 (GMP, type A medicated articles)
262:Current good manufacturing practices
2635:
1784:Workers' right to access the toilet
1625:Human right to water and sanitation
1457:211 (GMP, finished pharmaceuticals)
702:– via Google Books (Preview).
662:– via Google Books (Preview).
502:
480:National Health Surveillance Agency
13:
795:World Health Organization (2007).
14:
2699:
2057:Commercial determinants of health
1510:
1427:
2634:
2622:
2611:
2610:
1640:National public health institute
595:Corrective and preventive action
476:Therapeutic Goods Administration
472:Ministry of Food and Drug Safety
29:
2037:Open-source healthcare software
1779:Sociology of health and illness
1029:
907:
882:
869:US-Food and Drug Administration
527:(GAP), for farming and ranching
16:Manufacturing quality standards
2398:Caribbean Public Health Agency
2210:Sexually transmitted infection
2107:Statistical hypothesis testing
1868:Occupational safety and health
1769:Sexual and reproductive health
1682:Occupational safety and health
1120:"Good Manufacturing Practices"
856:
841:
817:
460:
449:Since the 1999 publication of
1:
2052:Social determinants of health
1444:European Union GMP Guidelines
627:
2112:Analysis of variance (ANOVA)
1873:Human factors and ergonomics
474:(MFDS); in Australia by the
408:Food and Drug Administration
355:good documentation practices
7:
2293:Good manufacturing practice
2097:Randomized controlled trial
652:. London: Wiley-Blackwell.
583:
510:Food, Drug and Cosmetic Act
305:good agricultural practices
51:Good manufacturing practice
10:
2704:
2363:Theory of planned behavior
2288:Good agricultural practice
2193:Public health surveillance
2085:epidemiological statistics
1729:Public health intervention
1465:225 (GMP, medicated feeds)
688:. In Lintner, Karl (ed.).
525:Good agricultural practice
2606:
2541:
2500:
2485:World Toilet Organization
2480:World Health Organization
2387:
2376:
2313:
2238:
2154:
2082:
2047:Public health informatics
1987:
1792:
1754:Right to rest and leisure
1583:Globalization and disease
1518:
716:Nally, J.D., ed. (2007).
432:World Health Organization
309:good laboratory practices
298:quality management system
2531:Schools of public health
2323:Diffusion of innovations
2022:Health impact assessment
1734:Public health laboratory
1630:Management of depression
914:Frederick, Tami (2019).
552:Good laboratory practice
2673:Pharmaceutical industry
2594:Social hygiene movement
2521:Doctor of Public Health
2353:Social cognitive theory
2155:Infectious and epidemic
1937:Fecal–oral transmission
1348:The Gazette of Pakistan
436:pharmaceutical industry
313:good clinical practices
282:pharmaceutical products
2688:Life sciences industry
2678:Pharmaceuticals policy
2589:Germ theory of disease
2368:Transtheoretical model
1100:. Pharmaceutical Press
531:Good clinical practice
69:Critical control point
2473:Public Health Service
2358:Social norms approach
2348:PRECEDE–PROCEED model
1794:Preventive healthcare
1687:Pharmaceutical policy
1536:Chief Medical Officer
1341:"S.R.O. 1012(I)/2017"
486:; in Pakistan by the
208:Entamoeba histolytica
116:Clostridium botulinum
2549:Sara Josephine Baker
2448:Public Health Agency
2333:Health communication
2198:Disease surveillance
2164:Asymptomatic carrier
2146:Statistical software
1834:Preventive nutrition
1662:Medical anthropology
1551:Environmental health
684:Moore, Iain (2009).
516:Other good practices
2668:Dietary supplements
2559:Carl Rogers Darnall
2554:Samuel Jay Crumbine
2328:Health belief model
2181:Notifiable diseases
2117:Regression analysis
1952:Waterborne diseases
1541:Cultural competence
1476:Batch Record Design
566:studies in animals)
421:dietary supplements
410:(FDA), under Title
338:cross-contamination
286:dietary supplements
192:Parasitic pathogens
107:Bacterial pathogens
2157:disease prevention
2092:Case–control study
1764:Security of person
1613:Health care reform
1453:210 (GMP, general)
1386:on 3 February 2018
1357:on 2 February 2018
1318:on 3 February 2018
402:Guideline versions
319:High-level details
2650:
2649:
2602:
2601:
2512:Higher education
2343:Positive deviance
2338:Health psychology
2314:Health behavioral
2241:safety management
2215:Social distancing
1989:Population health
1969:Smoking cessation
1917:Pharmacovigilance
1888:Injury prevention
1856:Infection control
1774:Social psychology
1724:Prisoners' rights
1667:Medical sociology
1635:Public health law
1531:Biological hazard
1236:on April 29, 2017
389:product quality.
259:
258:
95:Water activity (a
46:Foodborne illness
2695:
2638:
2637:
2626:
2625:
2614:
2613:
2508:Health education
2385:
2384:
2239:Food hygiene and
2220:Tropical disease
2032:Infant mortality
2007:Community health
1883:Controlled Drugs
1819:Health promotion
1749:Right to housing
1593:Health economics
1505:
1498:
1491:
1482:
1481:
1421:
1420:
1418:
1416:
1410:
1402:
1396:
1395:
1393:
1391:
1380:"GMP Guidelines"
1376:
1367:
1366:
1364:
1362:
1356:
1345:
1337:
1328:
1327:
1325:
1323:
1308:
1299:
1298:
1296:
1294:
1288:
1280:
1274:
1273:
1271:
1269:
1263:
1255:
1246:
1245:
1243:
1241:
1225:
1216:
1215:
1213:
1211:
1200:
1191:
1190:
1188:
1186:
1180:
1171:
1162:
1161:
1159:
1157:
1142:
1136:
1135:
1133:
1131:
1116:
1110:
1109:
1107:
1105:
1093:
1084:
1083:
1061:
1052:
1051:
1049:
1047:
1033:
1027:
1026:
1024:
1022:
1011:
1005:
1004:
1002:
1000:
989:
980:
979:
977:
975:
964:
958:
957:
955:
953:
942:
933:
932:
930:
929:
920:
911:
905:
904:
902:
901:
886:
880:
879:
877:
875:
860:
854:
853:
845:
839:
838:
836:
835:
821:
815:
814:
792:
786:
785:
765:
759:
758:
756:
754:
743:
734:
733:
713:
704:
703:
681:
664:
663:
643:
617:Site Master File
556:clinical studies
503:CGMP inspections
490:; in Nigeria by
251:
244:
237:
123:Escherichia coli
77:Critical factors
33:
19:
18:
2703:
2702:
2698:
2697:
2696:
2694:
2693:
2692:
2653:
2652:
2651:
2646:
2598:
2569:Margaret Sanger
2537:
2496:
2380:
2378:
2372:
2315:
2309:
2281:Safety scandals
2240:
2234:
2156:
2150:
2084:
2078:
2074:Social medicine
2067:Race and health
2002:Child mortality
1983:
1942:Open defecation
1824:Human nutrition
1814:Family planning
1802:Behavior change
1788:
1744:Right to health
1657:Maternal health
1647:Health politics
1598:Health literacy
1514:
1509:
1449:US CFR Title 21
1430:
1425:
1424:
1414:
1412:
1408:
1404:
1403:
1399:
1389:
1387:
1378:
1377:
1370:
1360:
1358:
1354:
1343:
1339:
1338:
1331:
1321:
1319:
1310:
1309:
1302:
1292:
1290:
1286:
1282:
1281:
1277:
1267:
1265:
1261:
1257:
1256:
1249:
1239:
1237:
1226:
1219:
1209:
1207:
1202:
1201:
1194:
1184:
1182:
1178:
1172:
1165:
1155:
1153:
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1829:Healthy diet
1759:Right to sit
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2641:WikiProject
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1974:Vaccination
1846:Food safety
829:www.trb.org
606:Food safety
533:(GCP), for
461:Enforcement
416:adulterated
364:documented.
222:Trichinella
174:Hepatitis A
169:Enterovirus
151:Cronobacter
23:Food safety
2657:Categories
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2205:Quarantine
2127:Student's
1927:Sanitation
1561:History of
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1390:2 February
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1130:2 February
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999:2 February
974:2 February
952:2 February
928:2020-12-09
900:2020-12-10
874:October 9,
834:2020-12-28
753:2 February
628:References
560:toxicology
539:clinicians
137:Salmonella
2574:John Snow
2501:Education
2491:Full list
2379:education
2303:ISO 22000
2256:Chemistry
2169:Epidemics
2122:ROC curve
1932:Emergency
1712:Radiation
1692:Pollution
1676:Ministers
1573:Euthenics
1066:"Preface"
1046:24 August
535:hospitals
453:, by the
345:validated
278:cosmetics
274:beverages
184:Rotavirus
179:Norovirus
2617:Category
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2251:Additive
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1893:Medicine
1807:Theories
1578:Genomics
1556:Eugenics
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1526:Auxology
622:Washdown
601:EudraLex
584:See also
130:Listeria
2629:Commons
2542:History
2439:Canada
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1878:Hygiene
1841:Hygiene
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1519:General
300:(QMS).
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53:(GMP)
38:Terms
2230:WASH
2186:List
2174:List
1707:Soil
1417:2018
1392:2018
1363:2018
1324:2018
1295:2018
1270:2018
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562:and
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