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40:
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patients; it is the excessive production along with the speed of secretion that leads to the formation of thick mucus that cannot be removed by cilia or coughing action. This, in addition to airway narrowing leads to the clogging of the airways, which can be detrimental to health if not treated.
643:
is the process by which the immune system is prevented from responding to antigen derived from food products, as peptides from food may pass into the bloodstream via the gut, which would in theory lead to an immune response. A paper published in
263:
The goblet cell is highly polarized with the nucleus and other organelles concentrated at the base of the cell and secretory granules containing mucin, at the apical surface. The apical plasma membrane projects short
580:
Mucins are continuously made and secreted by goblet cells in order to repair and replace the existing mucus layer. Mucins are stored in granules inside the goblet cells before being released to the
260:
refers to the cell's goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucus laden granules; its basal portion lacks these granules and is shaped like a stem.
604:
Anomalies in the number of goblet cells are associated with changes in the secretion of mucins, which can result in many of the abnormalities seen in asthma patients, such as clogged airways due to
1160:
921:
in 1867, Schulze chose the descriptive name "goblet" because of the shape of the cell, rather than a functional name, as he remained uncertain as to the mucus-producing function of the cell.
483:
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203:
2191:
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and goblet cells, latter indicated by arrows, and usually having a slightly bluish color compared to the apical cytoplasm of foveolar cells on H&E stain.
938:
573:, and propelled out of the lungs and into the pharynx, which results in the removal of debris and pathogens from the airway. MUC5AC is overexpressed in
2164:
924:
Nowadays these cells are used in the laboratories to evaluate the intestinal absorption of drug targets with different kits, such as the CacoGoblet.
825:
2757:
3415:
881:. These treatments have shown improvements in asthma patients, yet there are still limitations to the use of anti-IL-13 monoclonal antibodies.
1897:"Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998"
1063:"The Role of Guaifenesin in the Management of Chronic Mucus Hypersecretion Associated with Stable Chronic Bronchitis: A Comprehensive Review"
452:
1776:"15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells"
3408:
2184:
585:
of the organ. Mucin secretion in the airway may occur via regulated secretion. Secretion may be stimulated by irritants such as
446:, deep red mucin is found within goblet cell bodies. Goblet cells can be seen in the examples below as the larger, more pale cells.
538:(bound carbohydrates) attracting relatively large quantities of water. On the inner surface of the human intestine, it forms a 200
1236:
3021:
2779:
2466:
2424:
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2177:
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in 2012 has shed some light on the process and implicated goblet cells as having a role in the process. It was known that
416:
2915:
1576:
1261:
766:(15-LO-1), which is an enzyme involved in the breakdown of unsaturated fatty acids. 15-lipoxygenase acts by binding to
664:), and this paper suggests that the goblet cells act to preferentially deliver antigen to these CD103 dendritic cells.
2920:
2074:
1045:
979:
1179:
3569:
210:
2303:
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monomers, which themselves are phosphorylated and then subsequently leave the receptor and congregate form STAT6
2004:
Vatrella, Alessandro; Fabozzi, Immacolata; Calabrese, Cecilia; Maselli, Rosario; Pelaia, Girolamo (2014-09-04).
3745:
2461:
1708:"lnterleukin-4, lnterleukin-13, Signal Transducer and Activator of Transcription factor 6, and Allergic Asthma"
436:
3095:
2735:
198:
44:
Schematic illustration of a goblet cell in close up, illustrating different internal structures of the cell.
2209:
910:
574:
316:
272:
17:
1502:
Birchenough, G. M. H.; Johansson, M. Ev; Gustafsson, J. K.; Bergström, J. H.; Hansson, G. C. (July 2015).
3703:
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had a role to play in the induction of oral tolerance (potentially by inducing the differentiation of
191:
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2558:
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of airway epithelial cells into mucin producing goblet cells. These cells produce the thick mucins
186:
174:
1770:
Zhao, Jinming; O'Donnell, Valerie B.; Balzar, Silvana; St. Croix, Claudette M.; Trudeau, John B.;
793:
are a class of rare tumors that form as a result of an excessive proliferation of both goblet and
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284:
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of the esophagus into intestinal epithelium, characterized by the presence of goblet cells.
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8:
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of goblet cells tends to be displaced toward the basal end of the cell body by the large
79:
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thick layer (less in other animals) that lubricates and protects the wall of the organ.
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2005:
1972:
1945:
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1598:"Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine"
1597:
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1503:
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in 1837 when studying the lining of the small intestine, seen to be mucus producing by
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2017:
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150:
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1129:
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582:
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400:
340:
312:
287:, into goblet cells plays a key role in the excessive mucus production, known as
179:
136:
2882:
2877:
917:
in 1857 (who was examining the epidermis of fish), and were given their name by
3717:
3674:
3669:
3664:
3457:
3379:
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3314:
3276:
3159:
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2414:
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1780:
Proceedings of the
National Academy of Sciences of the United States of America
1723:
890:
866:
759:
720:
708:
704:
657:
653:
364:
2765:
1180:"Structure and biological roles of mucin-type O-glycans at the ocular surface"
693:, which clog the airway, leading to the airflow obstruction characteristic of
3739:
3637:
3581:
3559:
3512:
3488:
3233:
2995:
2990:
2980:
2957:
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1809:
1731:
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1470:
1461:
1297:
886:
834:
740:
621:
101:
1800:
1583:- Digestive System: Alimentary Canal: fundic stomach, gastric glands, lumen"
873:
patients. Some treatments that use anti-IL-13 monoclonal antibodies include
3596:
3549:
3544:
3309:
3299:
2985:
2965:
2942:
2937:
2824:
2367:
2334:
2324:
2250:
2049:
1981:
1962:
1922:
1881:
1827:
1771:
1749:
1677:
1639:
1545:
1488:
1418:
1364:
1315:
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1098:
914:
878:
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814:
806:
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531:
527:
428:
412:
404:
368:
121:
107:
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1862:
1399:
1022:
677:
The excessive mucus production seen in allergic asthma patients is due to
3304:
3241:
3077:
3050:
2771:
2623:
2267:
420:
352:
344:
332:
1621:
994:
3614:
3526:
3359:
3294:
3286:
3062:
2648:
2573:
2372:
2293:
2022:
1913:
1896:
1519:
1501:
901:
is a more effective form of treatment as it targets both interleukins.
845:
778:, a phospholipid component. 15-HETE-PE induces expression of the mucin
747:, where they bind to regulatory elements in the DNA, which affects the
682:
539:
408:
308:
276:
265:
93:
1656:
Lambrecht, Bart N; Hammad, Hamida (2015). "The immunology of asthma".
1346:
700:
Goblet cell metaplasia in allergic asthma is due to the action of the
271:
Goblet cells are typically found in the respiratory, reproductive and
216:
39:
3681:
3374:
3364:
2866:
2643:
2506:
2355:
1231:(6th ed.). Lippincott Williams & Wilkins. pp. 592â593.
898:
882:
810:
779:
686:
629:
609:
424:
388:
247:
243:
61:
1669:
3712:
3500:
3493:
3477:
3087:
2452:
2431:
2298:
1443:
Adler, Kenneth Bruce; Tuvim, Michael J.; Dickey, Burton F. (2013).
995:
Lohmann-Matthes, M-L.; SteinmĂŒller, C.; Franke-Ullmann, G. (1994).
862:
770:
and yields hydroperoxy and epoxy metabolites. One such metabolite,
728:
701:
690:
598:
254:
methods, budding off their secretions, when under stress. The term
251:
813:
is also performed. Disseminated tumors may require treatment with
3462:
3449:
3125:
2947:
2904:
2788:
2343:
625:
328:
324:
250:
method of secretion, secreting vesicles into a duct, but may use
239:
73:
1769:
1383:"Secretion properties, clearance, and therapy in airway disease"
897:. Since IL-4 and IL-13 have interrelated biological activities,
545:
Distinct forms of mucin are produced in different organs: while
522:
where they are found. Goblet cells accomplish this by secreting
3263:
2478:
2436:
2348:
2319:
2238:
2003:
962:
Hodges, R.R.; Dartt, D.A. (2010). "Conjunctival Goblet Cells".
870:
774:(15-HETE), is released intracellularly, where it conjugates to
763:
694:
613:
562:
550:
535:
372:
360:
348:
296:
256:
1504:"New developments in goblet cell mucus secretion and function"
1038:
Anatomy & physiology : the unity of form and function
387:
cells, having a height of four times that of their width. The
3182:
3141:
2473:
2275:
2199:
755:
736:
716:
649:
590:
554:
523:
515:
475:
392:
356:
235:
162:
146:
2681:
586:
546:
435:
of microscopy samples. However, they stain easily with the
246:
in the respiratory tract. The goblet cells mainly use the
51:
3430:
1943:
1706:
Kuperman, Douglas A.; Schleimer, Robert P. (August 2008).
805:. The main treatment for localized goblet cells tumors is
2063:
Felts, William J. L.; Harrison, Richard J. (2015-08-26).
1282:"The gastrointestinal mucus system in health and disease"
1112:
Evans, CM; Kim, K; Tuvim, MJ; Dickey, BF (January 2009).
1061:
Ohar, JA; Donohue, JF; Spangenthal, S (23 October 2019).
801:
and may present symptoms similar to the much more common
489:
Section of mouse intestine, mucus of goblet cells in blue
359:
and they also secrete different types of mucins onto the
2066:
International Review of
General and Experimental Zoology
1445:"Regulated Mucin Secretion from Airway Epithelial Cells"
608:, and eventual loss of lung function. Overexpression of
1279:
1254:
Wheater's
Functional Histology: A Text and Colour Atlas
1251:
1944:
Fouad, YM; Mostafa, I; Yehia, R; El-Khayat, H (2014).
1894:
1177:
1060:
620:
There are other cells that secrete mucus (such as the
192:
H3.04.03.0.00009, H3.04.03.0.00016, H3.05.00.0.00006
3701:
1895:
McCusker, ME; Coté, TR; Clegg, LX; Sobin, LH (2002).
934:
List of human cell types derived from the germ layers
612:
alone does not result in the pathophysiology seen in
534:. The gel-like properties of mucins are given by its
1275:
1273:
1114:"Mucus hypersecretion in asthma: causes and effects"
885:
is a newer drug that targets the shared receptor of
1111:
939:
List of distinct cell types in the adult human body
869:results in decreased expression of goblet cells in
423:. Mucin within the granules stains pale in routine
743:in the cytoplasm. These homodimers then enter the
462:from the human intestine with goblet cells visible
70:, here somewhat shrunken away from the epithelium.
1950:World Journal of Gastrointestinal Pathophysiology
1705:
1286:Nature Reviews. Gastroenterology & Hepatology
1270:
268:to give an increased surface area for secretion.
3737:
1565:A Learning System in Histology: CD-ROM and Guide
1442:
1328:
1655:
1591:
1589:
751:of certain genes involved in mucus production.
988:
3416:
2751:
2185:
2062:
1040:(6th ed.). McGraw-Hill. pp. 88â89.
829:Incomplete intestinal metaplasia (incomplete
439:staining method, which colours them magenta.
291:seen in many respiratory diseases, including
1586:
1280:Johansson ME, Sjövall H, Hansson GC (2013).
797:. The majority of these tumors arise in the
514:The main role of goblet cells is to secrete
275:and are surrounded by other columnar cells.
2135:
1843:
1226:
961:
307:Goblet cells are found scattered among the
3423:
3409:
2758:
2744:
2192:
2178:
407:. This gives the basal part of the cell a
403:, which lies between the granules and the
50:
38:
2093:"Chapter IV:The Goblet Cell in General".
2039:
2021:
2006:"Dupilumab: a novel treatment for asthma"
1971:
1961:
1912:
1871:
1861:
1817:
1799:
1739:
1629:
1535:
1478:
1460:
1408:
1398:
1354:
1322:
1305:
1203:
1137:
1088:
1078:
1012:
785:
635:
242:in the lower gastrointestinal tract, and
2616:
1888:
1846:"Goblet cell carcinoids of the appendix"
1380:
1376:
1374:
856:
824:
667:
1839:
1837:
1562:
1178:Guzman-Aranguez, A; ArgĂŒeso, P (2010).
1035:
561:. In the airway, mucus is swept by the
14:
3738:
1595:
1256:(6th ed.). Elsevier. p. 94.
1252:Young B, Woodford P, O'Dowd G (2013).
1245:
1067:Chronic Obstructive Pulmonary Diseases
1029:
557:are the main forms found in the human
355:goblet cells are a source of mucin in
3404:
2739:
2173:
2088:
2086:
1999:
1997:
1995:
1993:
1991:
1937:
1765:
1763:
1761:
1759:
1701:
1699:
1697:
1695:
1651:
1649:
1438:
1436:
1434:
1432:
1430:
1428:
1371:
1171:
1118:Current Opinion in Pulmonary Medicine
431:-rich proteins are washed out in the
1834:
1105:
957:
955:
953:
762:leads to increased of expression of
395:granules, which accumulate near the
27:Epithelial cells that secrete mucins
2165:Goblet Cells at cvmbs.colostate.edu
1946:"Biomarkers of Barrett's esophagus"
1220:
1054:
24:
2107:10.1111/j.1755-3768.1968.tb05926.x
2083:
1988:
1756:
1692:
1646:
1425:
1387:Translational Respiratory Medicine
972:10.1016/b978-0-12-374203-2.00053-1
672:
427:sections, primarily because these
25:
3767:
2158:
1329:Johansson ME, Hansson GC (2013).
950:
861:Studies of mice given monoclonal
3723:
3711:
2136:VĂĄzquez-SĂĄnchez, MarĂa Ăngeles.
719:signalling response. Binding of
494:
482:
467:
451:
232:simple columnar epithelial cells
211:Anatomical terms of microanatomy
98:fâ. Leucocytes below epithelium.
2129:
2056:
1552:
1495:
549:is prevalent in the intestine,
378:
1154:
909:The cells were first noted by
811:removal of the right hemicolon
772:15-hydroxyeicosatetranoic acid
628:) but these are distinguished
601:such as viruses and bacteria.
399:surface of the cell along the
168:exocrimohsinoctus caliciformis
13:
1:
2408:Bile and pancreatic secretion
2010:Journal of Asthma and Allergy
1196:10.1016/S1542-0124(12)70213-6
1080:10.15326/jcopdf.6.4.2019.0139
944:
851:
820:
735:. This results in docking of
1850:The Scientific World Journal
1844:Holt, N; GrĂžnbĂŠk, H (2013).
1596:McDole; et al. (2012).
1166:Dorland's Medical Dictionary
1130:10.1097/MCP.0b013e32831da8d3
1014:10.1183/09031936.94.07091678
1001:European Respiratory Journal
575:hypersensitivity pneumonitis
323:. They are found inside the
302:
273:lower gastrointestinal tract
7:
3006:Enterochromaffin-like cells
1331:"Mucus and the Goblet Cell"
1229:Histology: A Text and Atlas
927:
509:
417:rough endoplasmic reticulum
10:
3772:
2628:Interstitial cell of Cajal
2101:(S95): 25â35. 1968-02-01.
1724:10.2174/156652408785161032
1712:Current Molecular Medicine
1449:Frontiers in Endocrinology
1227:Ross M, Pawlina W (2011).
904:
385:simple columnar epithelial
335:in the respiratory tract,
3657:
3605:
3592:Middle lobe of right lung
3534:
3525:
3476:
3448:
3439:
3346:
3285:
3262:
3199:
3181:
3172:
3140:
3124:
3086:
3038:
3029:
3020:
2903:
2865:
2787:
2778:
2715:
2703:Enterohepatic circulation
2695:
2674:
2665:
2609:
2586:
2559:Segmentation contractions
2551:
2535:
2515:
2489:
2447:
2407:
2394:
2387:
2333:
2312:
2286:
2224:
2217:
2208:
2069:. Elsevier. p. 244.
1563:Vaughan, Deborah (2002).
715:receptor and initiates a
234:that secrete gel-forming
209:
197:
185:
173:
161:
156:
142:
132:
120:
115:
49:
37:
32:
1559:Histology image:11303loa
1462:10.3389/fendo.2013.00129
1298:10.1038/nrgastro.2013.35
817:in addition to surgery.
776:phosphatidylethanolamine
518:in order to protect the
56:Transverse section of a
3433:lower respiratory tract
3330:External anal sphincter
3325:Intersphincteric groove
3320:Internal anal sphincter
2837:Pterygomandibular raphe
2633:Basal electrical rhythm
2564:Migrating motor complex
2202:gastrointestinal system
1801:10.1073/pnas.1018075108
1569:Oxford University Press
997:"Pulmonary macrophages"
964:Encyclopedia of the Eye
807:removal of the appendix
415:within the nucleus and
84:d. Its striated border.
3633:Respiratory bronchiole
3111:Duodenojejunal flexure
3106:Minor duodenal papilla
3101:Major duodenal papilla
2852:Pharyngobasilar fascia
2847:Buccopharyngeal fascia
2768:gastrointestinal tract
2588:Enteric nervous system
1963:10.4291/wjgp.v5.i4.450
838:
791:Goblet cell carcinoids
786:Goblet cell carcinoids
679:goblet cell metaplasia
636:Role in oral tolerance
569:, in a process called
567:respiratory epithelium
285:respiratory epithelium
277:Biased differentiation
3746:Mucus secreting cells
3068:Enteroendocrine cells
2502:Enterochromaffin cell
2497:Enteroendocrine cells
1400:10.1186/2213-0802-2-6
857:Monoclonal antibodies
828:
668:Clinical significance
571:mucociliary clearance
3587:Lingula of left lung
2490:Endocrine cell types
2095:Acta Ophthalmologica
966:. pp. 369â376.
795:neuroendocrine cells
606:mucus hypersecretion
597:. Other stimuli are
593:, especially in the
411:staining because of
289:mucus hypersecretion
3623:Terminal bronchiole
3001:Gastric chief cells
2516:Exocrine cell types
2449:Glucose homeostasis
1863:10.1155/2013/543696
1792:2011PNAS..10814246Z
1786:(34): 14246â14251.
1622:10.1038/nature10863
1614:2012Natur.483..345M
1036:Saladin, K (2012).
842:Barrett's esophagus
831:Barrett's esophagus
632:from goblet cells.
80:Columnar epithelium
2639:Gastrocolic reflex
2200:Physiology of the
2023:10.2147/JAA.S52387
1914:10.1002/cncr.10589
1520:10.1038/mi.2015.32
1508:Mucosal Immunology
1335:Digestive Diseases
1184:The Ocular Surface
839:
803:acute appendicitis
662:regulatory T cells
444:mucicarmine stains
321:respiratory tracts
293:chronic bronchitis
281:airway basal cells
127:Respiratory system
3699:
3698:
3695:
3694:
3648:Blood-air barrier
3521:
3520:
3463:Annular ligaments
3398:
3397:
3390:Muscularis mucosa
3342:
3341:
3338:
3337:
3252:epiploic appendix
3168:
3167:
3096:Suspensory muscle
3058:Intestinal glands
3016:
3015:
2733:
2732:
2711:
2710:
2661:
2660:
2657:
2656:
2596:Submucous plexus
2582:
2581:
2531:
2530:
2383:
2382:
1658:Nature Immunology
1608:(7389): 345â349.
1381:Rubin BK (2013).
1347:10.1159/000354683
1238:978-0-7817-7200-6
530:formed mostly by
383:Goblet cells are
225:
224:
220:
68:Basement membrane
60:, from the human
16:(Redirected from
3763:
3751:Epithelial cells
3728:
3727:
3726:
3716:
3715:
3707:
3629:Respiratory zone
3532:
3531:
3446:
3445:
3441:Respiratory tree
3425:
3418:
3411:
3402:
3401:
3272:Transverse folds
3229:Descending colon
3219:Transverse colon
3179:
3178:
3133:No substructures
3116:Brunner's glands
3046:Intestinal villi
3036:
3035:
3027:
3026:
2926:Angular incisure
2842:Pharyngeal raphe
2810:retropharyngeal
2785:
2784:
2770:, excluding the
2760:
2753:
2746:
2737:
2736:
2725:Peritoneal fluid
2687:Pancreatic juice
2672:
2671:
2614:
2613:
2601:Myenteric plexus
2543:Intestinal juice
2405:
2404:
2392:
2391:
2304:Gastric emptying
2256:Intrinsic factor
2222:
2221:
2215:
2214:
2194:
2187:
2180:
2171:
2170:
2153:
2152:
2150:
2148:
2133:
2127:
2126:
2090:
2081:
2080:
2060:
2054:
2053:
2043:
2025:
2001:
1986:
1985:
1975:
1965:
1941:
1935:
1934:
1916:
1892:
1886:
1885:
1875:
1865:
1841:
1832:
1831:
1821:
1803:
1772:Wenzel, Sally E.
1767:
1754:
1753:
1743:
1703:
1690:
1689:
1653:
1644:
1643:
1633:
1593:
1584:
1582:
1556:
1550:
1549:
1539:
1499:
1493:
1492:
1482:
1464:
1440:
1423:
1422:
1412:
1402:
1378:
1369:
1368:
1358:
1341:(3â4): 305â309.
1326:
1320:
1319:
1309:
1277:
1268:
1267:
1249:
1243:
1242:
1224:
1218:
1217:
1207:
1175:
1169:
1158:
1152:
1151:
1141:
1109:
1103:
1102:
1092:
1082:
1058:
1052:
1051:
1033:
1027:
1026:
1016:
1007:(9): 1678â1689.
992:
986:
985:
959:
833:), showing both
809:, and sometimes
731:residues at the
520:mucous membranes
501:Goblet cells in
498:
486:
471:
460:intestinal gland
455:
363:surface. In the
337:small intestines
217:edit on Wikidata
214:
151:epithelial cells
54:
42:
30:
29:
21:
3771:
3770:
3766:
3765:
3764:
3762:
3761:
3760:
3736:
3735:
3734:
3724:
3722:
3710:
3702:
3700:
3691:
3653:
3619:Conducting zone
3601:
3517:
3472:
3435:
3431:Anatomy of the
3429:
3399:
3394:
3334:
3281:
3258:
3224:Splenic flexure
3214:Hepatic flexure
3209:Ascending colon
3195:
3174:Large intestine
3164:
3160:Microfold cells
3155:Peyer's patches
3150:Ileocecal valve
3136:
3120:
3082:
3031:Small intestine
3012:
2899:
2861:
2815:parapharyngeal
2805:peripharyngeal
2774:
2766:Anatomy of the
2764:
2734:
2729:
2707:
2691:
2653:
2605:
2578:
2547:
2527:
2511:
2485:
2443:
2420:Cholecystokinin
2379:
2329:
2308:
2282:
2271:
2204:
2198:
2161:
2156:
2146:
2144:
2134:
2130:
2092:
2091:
2084:
2077:
2061:
2057:
2002:
1989:
1942:
1938:
1907:(12): 3307â12.
1893:
1889:
1842:
1835:
1768:
1757:
1704:
1693:
1670:10.1038/ni.3049
1654:
1647:
1594:
1587:
1579:
1557:
1553:
1500:
1496:
1441:
1426:
1379:
1372:
1327:
1323:
1278:
1271:
1264:
1250:
1246:
1239:
1225:
1221:
1176:
1172:
1159:
1155:
1110:
1106:
1059:
1055:
1048:
1034:
1030:
993:
989:
982:
960:
951:
947:
930:
907:
859:
854:
823:
788:
764:15-lipoxygenase
725:phosphorylation
683:differentiation
675:
673:Allergic asthma
670:
654:dendritic cells
638:
512:
505:
503:large intestine
499:
490:
487:
478:
474:Goblet cell in
472:
463:
456:
401:Golgi apparatus
381:
365:lacrimal glands
341:large intestine
305:
221:
137:Simple columnar
111:
105:
99:
97:
91:
85:
83:
77:
71:
65:
45:
28:
23:
22:
15:
12:
11:
5:
3769:
3759:
3758:
3753:
3748:
3733:
3732:
3720:
3697:
3696:
3693:
3692:
3690:
3689:
3684:
3679:
3678:
3677:
3672:
3665:Alveolar cells
3661:
3659:
3655:
3654:
3652:
3651:
3645:
3640:
3635:
3626:
3611:
3609:
3603:
3602:
3600:
3599:
3594:
3589:
3584:
3579:
3578:
3577:
3572:
3564:
3563:
3562:
3557:
3552:
3547:
3538:
3536:
3529:
3523:
3522:
3519:
3518:
3516:
3515:
3510:
3509:
3508:
3498:
3497:
3496:
3491:
3482:
3480:
3474:
3473:
3471:
3470:
3465:
3460:
3458:Tracheal rings
3454:
3452:
3443:
3437:
3436:
3428:
3427:
3420:
3413:
3405:
3396:
3395:
3393:
3392:
3387:
3382:
3380:Circular folds
3377:
3372:
3370:Muscular layer
3367:
3362:
3352:
3350:
3344:
3343:
3340:
3339:
3336:
3335:
3333:
3332:
3327:
3322:
3317:
3315:Pectinate line
3312:
3307:
3302:
3297:
3291:
3289:
3283:
3282:
3280:
3279:
3274:
3268:
3266:
3260:
3259:
3257:
3256:
3255:
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3249:
3244:
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3119:
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3098:
3092:
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3081:
3080:
3075:
3070:
3065:
3060:
3055:
3054:
3053:
3042:
3040:
3033:
3024:
3018:
3017:
3014:
3013:
3011:
3010:
3009:
3008:
3003:
2998:
2996:Parietal cells
2993:
2991:Foveolar cells
2988:
2986:Pyloric glands
2983:
2978:
2976:Cardiac glands
2973:
2971:Gastric glands
2968:
2960:
2955:
2953:Gastric mucosa
2950:
2945:
2940:
2935:
2930:
2929:
2928:
2923:
2918:
2909:
2907:
2901:
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2892:
2887:
2886:
2885:
2880:
2871:
2869:
2863:
2862:
2860:
2859:
2857:Pyriform sinus
2854:
2849:
2844:
2839:
2834:
2833:
2832:
2827:
2822:
2820:retrovisceral
2817:
2812:
2807:
2799:
2793:
2791:
2782:
2776:
2775:
2763:
2762:
2755:
2748:
2740:
2731:
2730:
2728:
2727:
2721:
2719:
2717:Abdominopelvic
2713:
2712:
2709:
2708:
2706:
2705:
2699:
2697:
2693:
2692:
2690:
2689:
2684:
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2663:
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2659:
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2456:
2445:
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2429:
2428:
2427:
2417:
2415:Enterogastrone
2411:
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2296:
2290:
2288:
2284:
2283:
2281:
2280:
2279:
2278:
2273:
2269:
2263:Foveolar cells
2260:
2259:
2258:
2253:
2246:Parietal cells
2243:
2242:
2241:
2230:
2228:
2219:
2212:
2206:
2205:
2197:
2196:
2189:
2182:
2174:
2168:
2167:
2160:
2159:External links
2157:
2155:
2154:
2128:
2082:
2075:
2055:
1987:
1956:(4): 450â456.
1936:
1887:
1833:
1774:(2011-08-23).
1755:
1718:(5): 384â392.
1691:
1645:
1585:
1578:978-0195151732
1577:
1551:
1514:(4): 712â719.
1494:
1424:
1370:
1321:
1292:(6): 352â361.
1269:
1263:978-0702047473
1262:
1244:
1237:
1219:
1170:
1153:
1104:
1073:(4): 341â349.
1053:
1046:
1028:
987:
980:
948:
946:
943:
942:
941:
936:
929:
926:
906:
903:
858:
855:
853:
850:
835:foveolar cells
822:
819:
787:
784:
674:
671:
669:
666:
658:lamina propria
641:Oral tolerance
637:
634:
630:histologically
622:foveolar cells
511:
508:
507:
506:
500:
493:
491:
488:
481:
479:
473:
466:
464:
457:
450:
419:staining with
380:
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315:, such as the
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96:in epithelium.
55:
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26:
9:
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3649:
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3644:
3641:
3639:
3638:Alveolar duct
3636:
3634:
3630:
3627:
3624:
3620:
3616:
3613:
3612:
3610:
3608:
3604:
3598:
3597:Inferior lobe
3595:
3593:
3590:
3588:
3585:
3583:
3582:Superior lobe
3580:
3576:
3573:
3571:
3568:
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3261:
3253:
3250:
3248:
3245:
3243:
3240:
3239:
3237:
3235:
3234:Sigmoid colon
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
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2984:
2982:
2981:Fundic glands
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2963:
2962:Microanatomy
2961:
2959:
2958:Gastric folds
2956:
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1161:"goblet cell"
1157:
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1047:9780073378251
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981:9780123742032
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769:
768:phospholipids
765:
761:
758:signaling by
757:
754:Induction of
752:
750:
749:transcription
746:
742:
738:
734:
730:
726:
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714:
711:binds to the
710:
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543:
541:
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533:
532:carbohydrates
529:
528:glycoproteins
525:
521:
517:
504:
497:
492:
485:
480:
477:
470:
465:
461:
454:
449:
448:
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434:
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426:
422:
418:
414:
413:nucleic acids
410:
406:
402:
398:
394:
390:
386:
376:
374:
370:
366:
362:
358:
354:
350:
347:in the upper
346:
342:
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331:, and larger
330:
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318:
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145:
141:
138:
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131:
128:
125:
123:
119:
114:
109:
103:
102:Blood vessels
95:
89:
81:
75:
69:
63:
59:
53:
48:
41:
36:
31:
19:
3686:
3310:Anal sinuses
3300:Anal columns
3078:Paneth cells
3073:Goblet cells
3072:
3039:Microanatomy
2966:Gastric pits
2830:prevertebral
2523:Goblet cells
2522:
2368:Somatostatin
2335:Gastric acid
2325:Gastric acid
2251:Gastric acid
2145:. Retrieved
2141:
2138:"CacoGoblet"
2131:
2098:
2094:
2065:
2058:
2013:
2009:
1953:
1949:
1939:
1904:
1900:
1890:
1853:
1849:
1783:
1779:
1715:
1711:
1664:(1): 45â56.
1661:
1657:
1605:
1601:
1564:
1554:
1511:
1507:
1497:
1452:
1448:
1390:
1386:
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1117:
1107:
1070:
1066:
1056:
1037:
1031:
1004:
1000:
990:
963:
923:
908:
879:lebrikizumab
875:tralokinumab
860:
840:
815:chemotherapy
789:
753:
699:
678:
676:
652:-expressing
645:
639:
619:
603:
579:
544:
513:
441:
429:carbohydrate
382:
379:Microanatomy
373:acinar cells
306:
270:
262:
255:
228:Goblet cells
227:
226:
167:
108:Muscle cells
88:Goblet cells
87:
18:Goblet cells
3756:Human cells
3687:Goblet cell
3305:Anal valves
3242:taenia coli
3238:Continuous
3063:Enterocytes
2912:Curvatures
2874:Sphincters
2624:Peristalsis
2610:Either/both
2569:Borborygmus
2234:Chief cells
2016:: 123â130.
1190:(1): 8â17.
1124:(1): 4â11.
433:preparation
421:hematoxylin
369:synthesized
367:, mucus is
353:conjunctiva
345:conjunctiva
333:bronchioles
157:Identifiers
149:-producing
110:cut across.
33:Goblet cell
3740:Categories
3615:Bronchiole
3607:BP segment
3570:Horizontal
3541:Landmarks
3506:eparterial
3360:Adventitia
3287:Anal canal
3051:Microvilli
2649:Enterocyte
2574:Defecation
2294:Swallowing
2239:Pepsinogen
1856:: 543696.
945:References
863:antibodies
852:Treatments
846:metaplasia
821:Metaplasia
741:homodimers
409:basophilic
317:intestinal
311:lining of
309:epithelial
266:microvilli
94:Leucocytes
3682:Club cell
3566:Fissures
3501:Secondary
3375:Submucosa
3365:Subserosa
2867:Esophagus
2696:Processes
2667:Accessory
2644:Digestion
2617:Processes
2552:Processes
2507:APUD cell
2453:incretins
2400:paracrine
2396:Endocrine
2361:ECL cells
2356:Histamine
2337:secretion
2287:Processes
2142:Readycell
2123:221392598
2115:1755-3768
2032:1178-6965
1810:0027-8424
1732:1566-5240
1528:1933-0219
1471:1664-2392
899:Dupilumab
883:Dupilumab
425:histology
389:cytoplasm
375:instead.
351:. In the
303:Structure
248:merocrine
244:mucin 5AC
62:intestine
3730:Medicine
3643:Alveolus
3513:Tertiary
3191:Appendix
3088:Duodenum
2432:Secretin
2299:Vomiting
2226:Exocrine
2210:GI tract
2050:25214796
1982:25400988
1931:40814989
1923:12115365
1882:23365545
1828:21831839
1750:18691065
1678:25521684
1640:22422267
1546:25872481
1489:24065956
1419:25505698
1393:(6): 6.
1365:24246979
1316:23478383
1214:20105403
1148:19077699
1099:31647856
928:See also
799:appendix
729:tyrosine
702:cytokine
599:microbes
526:, large
510:Function
252:apocrine
143:Function
64:. X 350.
3718:Biology
3704:Portals
3675:Type II
3575:Oblique
3535:General
3478:Bronchi
3450:Trachea
3277:Ampulla
3247:haustra
3126:Jejunum
2948:Pylorus
2916:greater
2905:Stomach
2801:Spaces
2797:Muscles
2789:Pharynx
2479:L cells
2467:K cells
2437:S cells
2425:I cells
2373:D cells
2349:G cells
2344:Gastrin
2147:20 July
2041:4159398
1973:4231509
1873:3556879
1819:3161579
1788:Bibcode
1741:4437630
1686:5451867
1631:3313460
1610:Bibcode
1537:4631840
1480:3776272
1455:: 129.
1410:4215824
1356:4282926
1307:3758667
1205:2847370
1139:2709596
1090:7006698
1023:7995399
919:Schulze
905:History
745:nucleus
723:causes
656:of the
626:stomach
624:of the
617:
565:of the
536:glycans
405:nucleus
329:bronchi
325:trachea
283:in the
240:mucin 2
238:, like
180:D020397
116:Details
74:Lacteal
3670:Type I
3468:Carina
3385:Mucosa
3356:Serosa
3264:Rectum
2943:Fundus
2933:Cardia
2921:lesser
2890:glands
2825:danger
2675:Fluids
2536:Fluids
2320:Saliva
2313:Fluids
2121:
2113:
2073:
2048:
2038:
2030:
1980:
1970:
1929:
1921:
1901:Cancer
1880:
1870:
1826:
1816:
1808:
1748:
1738:
1730:
1684:
1676:
1638:
1628:
1602:Nature
1575:
1544:
1534:
1526:
1487:
1477:
1469:
1417:
1407:
1363:
1353:
1314:
1304:
1260:
1235:
1212:
1202:
1146:
1136:
1097:
1087:
1044:
1021:
978:
915:Leydig
877:, and
871:asthma
780:MUC5AC
733:IL-4Rα
713:IL-4Rα
695:asthma
687:MUC5AC
681:, the
646:Nature
614:asthma
610:MUC5AC
595:airway
559:airway
551:MUC5AC
524:mucins
397:apical
361:ocular
349:eyelid
343:, and
339:, the
313:organs
297:asthma
295:, and
257:goblet
236:mucins
122:System
58:villus
3658:Cells
3560:Hilum
3527:Lungs
3494:right
3485:Main
3201:Colon
3183:Cecum
3142:Ileum
3022:Lower
2883:lower
2878:upper
2780:Upper
2772:mouth
2474:GLP-1
2388:Lower
2276:Mucus
2218:Upper
2119:S2CID
1927:S2CID
1682:S2CID
1561:from
911:Henle
895:IL4Rα
891:IL-13
867:IL-13
844:is a
760:IL-13
756:STAT6
737:STAT6
721:IL-13
717:STAT6
709:IL-13
705:IL-13
691:MUC5B
650:CD103
591:smoke
583:lumen
563:cilia
555:MUC5B
516:mucus
476:ileum
393:mucin
357:tears
215:[
204:13148
163:Latin
147:Mucin
133:Shape
3555:Root
3550:Apex
3545:Base
3489:left
3348:Wall
3295:Anus
2938:Body
2895:crop
2682:Bile
2149:2018
2111:ISSN
2071:ISBN
2046:PMID
2028:ISSN
1978:PMID
1919:PMID
1878:PMID
1854:2013
1824:PMID
1806:ISSN
1746:PMID
1728:ISSN
1674:PMID
1636:PMID
1573:ISBN
1542:PMID
1524:ISSN
1485:PMID
1467:ISSN
1415:PMID
1361:PMID
1312:PMID
1258:ISBN
1233:ISBN
1210:PMID
1144:PMID
1095:PMID
1042:ISBN
1019:PMID
976:ISBN
889:and
887:IL-4
865:for
689:and
589:and
587:dust
553:and
547:MUC2
319:and
230:are
175:MeSH
2462:GIP
2268:HCO
2103:doi
2036:PMC
2018:doi
1968:PMC
1958:doi
1909:doi
1868:PMC
1858:doi
1814:PMC
1796:doi
1784:108
1736:PMC
1720:doi
1666:doi
1626:PMC
1618:doi
1606:483
1532:PMC
1516:doi
1475:PMC
1457:doi
1405:PMC
1395:doi
1351:PMC
1343:doi
1302:PMC
1294:doi
1200:PMC
1192:doi
1163:at
1134:PMC
1126:doi
1085:PMC
1075:doi
1009:doi
968:doi
727:of
458:An
442:In
437:PAS
371:by
279:of
199:FMA
106:h.
100:g.
92:f.
86:e.
78:c.
72:b.
66:a.
3742::
3617::
3358:/
2140:.
2117:.
2109:.
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2097:.
2085:^
2044:.
2034:.
2026:.
2012:.
2008:.
1990:^
1976:.
1966:.
1952:.
1948:.
1925:.
1917:.
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1899:.
1876:.
1866:.
1852:.
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1836:^
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1680:.
1672:.
1662:16
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1427:^
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1333:.
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1272:^
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1198:.
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1122:15
1120:.
1116:.
1093:.
1083:.
1069:.
1065:.
1017:.
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999:.
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952:^
893:,
782:.
707:.
697:.
577:.
540:ÎŒm
327:,
299:.
187:TH
3706::
3650:)
3631:(
3625:)
3621:(
3424:e
3417:t
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2759:e
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2635:)
2626:(
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2398:/
2270:3
2193:e
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2079:.
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2020::
2014:7
1984:.
1960::
1954:5
1933:.
1911::
1884:.
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1830:.
1798::
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1716:8
1688:.
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1581:.
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1421:.
1397::
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1194::
1188:8
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1025:.
1011::
1005:7
984:.
970::
219:]
104:.
90:.
82:.
76:.
20:)
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