Knowledge

George R. Pettit

Source đź“ť

272:
Dr. Gordon Cragg, former chief of the National Cancer Institute’s Natural Products Branch, stated Pettit “can truly be regarded as one of the great pioneers and giants in natural products and drug discovery, and he was among the first to explore the realm of marine organisms as a source of potential
546:. "Dr. George R. Pettit, professor of chemistry at Arizona State University, has written a book to offer a tabular survey of synthetic nucleotides and methods of synthesis.... The author is a graduate of Long Branch High School. He attended Monmouth College when it was a two-year college." 193:
Pettit’s overall strategy involved the harvesting of natural agents from marine organisms, microorganisms, insects, and plant specimens that were tested for anticancer components. Using this strategy, Pettit and his research group discovered multiple anti-cancer compounds, including
38:. He was an internationally renowned and respected researcher in the field of natural anticancer compounds throughout his career of over six decades. Pettit has been honored by the International Cancer Advocacy Network, the 269:
The late Professor Carl Djerassi described Pettit as “one of the great heroes in the chemistry of marine natural products out of which he created a battery of anti-cancer agents not equaled anywhere.”
213:
In 2020 Pettit retired after 55 years of service to ASU. During his tenure at ASU, Pettit published over 800 peer-reviewed research articles, 14 books, 17 book chapters, and received 70 U.S.
190:, serving as its director for 30 years. While at ASU, Pettit was appointed Dalton Professor of Cancer Research and Medicinal Chemistry, and later, Regents Professor of Chemistry. 343:
Cragg, Guest Editor, Gordon M.; Powell, Associate Editor, Richard G.; Singh, Guest Editor, Sheo B. (2008-03-01). "Special Issue in Honor of Professor George Robert Pettit".
31: 273:
antitumor agents. His early research in this area blossomed into a marine natural products drug discovery program of exceptional productivity and achievement.”
413: 391: 582: 183:, where he continued his anticancer research while training hundreds of graduate students and postdoctoral fellows throughout his career. 597: 617: 592: 202:, several of which advanced into preclinical and clinical trials for a wide range of cancers, and others have been approved by the 572: 69:
George Robert “Bob” Pettit was born on June 8, 1929, the eldest son of George Robert and Florence Elizabeth (Seymour) Pettit in
602: 612: 577: 319: 61:(NCI). Pettit and his impact on the field of anti-cancer compounds are the subject of the book, “Waging War on Cancer.” 491: 54:
paid tribute to him. Pettit’s achievements earned him the designation of Outstanding Investigator by the United States
587: 225: 39: 134: 440: 157: 55: 203: 229: 90: 47: 43: 259: 187: 153: 58: 180: 35: 74: 70: 607: 253: 142: 130: 106: 98: 384: 372: 247: 567: 562: 8: 161: 149: 148:
In 1957 Pettit left Norwich and began his teaching and anticancer research career at the
82: 78: 414:"Distinguished ASU cancer researcher George R. Pettit retires after 55 years of service" 133:. After graduating from Wayne State, Pettit was hired as a senior research chemist by 121:
Pettit’s foray in natural products chemistry began in the summer of 1953, working for
538: 487: 360: 138: 94: 265:
Research Achievement Award and a Fellowship in the American Society of Pharmacognosy
352: 533: 156:(NCI) in 1959. Later, he applied for and received a construction grant from the 543: 199: 556: 510: 364: 160:(NIH) to build a laboratory. Pettit continued his anticancer research at the 126: 110: 93:
in 1952 under the guidance of Professor Gardner Stacy. Pettit then earned a
290: 195: 356: 176: 172: 165: 86: 27: 23: 207: 218: 102: 214: 122: 320:"ASP Members Recognized Among Most Influential Scientists" 217:. His papers have been cited over 30,000 times. Pettit’s 141:. While there he worked on drug discovery related to the 77:, he attended Monmouth Junior College (since renamed as 441:"In memoriam: Regents Professor George 'Bob' Pettit" 145:yet remained passionate about anticancer research. 22:(June 8, 1929 – September 21, 2021) was a Regents’ 511:"Obituaries in Phoenix, AZ | The Arizona Republic" 129:, just prior to beginning his graduate studies at 542:, August 26, 1973. Accessed January 5, 2022, via 554: 342: 221:, a measure of his publications’ impact, is 89. 50:is dedicated to Pettit, and the French journal 228:, and also served as the senior editor of the 411: 244:State of Arizona Governor’s Excellence Award 152:. Pettit received his first grant from the 64: 46:, his alma mater. A special edition of the 390:CS1 maint: multiple names: authors list ( 164:until 1965, having been promoted to full 256:from the American Institute of Chemists 241:WSU Regents Distinguished Alumnus Award 555: 481: 505: 503: 477: 475: 473: 471: 469: 467: 465: 463: 461: 435: 433: 407: 405: 403: 401: 314: 312: 310: 250:in the Chemistry of Natural Products 583:People from Long Branch, New Jersey 13: 598:Washington State University alumni 412:Klemaszewski, James (2020-09-28). 14: 629: 618:American academic journal editors 500: 458: 430: 398: 307: 226:American Society of Pharmacognosy 40:American Society of Pharmacognosy 593:Arizona State University faculty 206:for the treatment of a range of 73:. Following his graduation from 534:"Pettit Pens Work For Chemists" 486:. Victoria, CA: Friesen Press. 198:, dolastatins/auristatins, and 171:In 1965, Pettit was hired as a 573:Long Branch High School alumni 527: 336: 283: 262:Outstanding Investigator Award 235: 135:Norwich Pharmaceutical Company 1: 603:Wayne State University alumni 276: 158:National Institutes of Health 56:National Institutes of Health 186:In 1975, Pettit founded the 32:School of Molecular Sciences 16:American chemist (1929–2021) 7: 613:University of Maine faculty 345:Journal of Natural Products 230:Journal of Natural Products 224:Pettit was a member of the 91:Washington State University 48:Journal of Natural Products 44:Washington State University 10: 634: 578:Monmouth University alumni 101:in 1954, and his Ph.D. in 260:National Cancer Institute 188:Cancer Research Institute 154:National Cancer Institute 116: 59:National Cancer Institute 588:Chemists from New Jersey 181:Arizona State University 65:Early life and education 36:Arizona State University 75:Long Branch High School 71:Long Branch, New Jersey 20:George Robert Pettit II 482:Byars, Robert (2015). 254:Chemical Pioneer Award 143:central nervous system 131:Wayne State University 107:Wayne State University 99:Heterocyclic Chemistry 248:Ernest Guenther Award 484:Waging War on Cancer 324:www.pharmacognosy.us 162:University of Maine 150:University of Maine 83:Bachelor of Science 79:Monmouth University 383:has generic name ( 81:. Pettit earned a 539:Asbury Park Press 357:10.1021/np700714j 291:"News - May 2020" 139:Norwich, New York 95:Master of Science 52:MĂ©dicine Sciences 625: 547: 531: 525: 524: 522: 521: 507: 498: 497: 479: 456: 455: 453: 452: 437: 428: 427: 425: 424: 409: 396: 395: 388: 382: 378: 376: 368: 340: 334: 333: 331: 330: 316: 305: 304: 302: 301: 287: 633: 632: 628: 627: 626: 624: 623: 622: 553: 552: 551: 550: 532: 528: 519: 517: 509: 508: 501: 494: 480: 459: 450: 448: 439: 438: 431: 422: 420: 410: 399: 389: 380: 379: 370: 369: 341: 337: 328: 326: 318: 317: 308: 299: 297: 289: 288: 284: 279: 238: 200:combretastatins 137:, and moved to 119: 105:Chemistry from 67: 17: 12: 11: 5: 631: 621: 620: 615: 610: 605: 600: 595: 590: 585: 580: 575: 570: 565: 549: 548: 544:Newspapers.com 526: 499: 493:978-1460259764 492: 457: 429: 397: 351:(3): 297–299. 335: 306: 281: 280: 278: 275: 267: 266: 263: 257: 251: 245: 242: 237: 234: 118: 115: 66: 63: 15: 9: 6: 4: 3: 2: 630: 619: 616: 614: 611: 609: 608:DuPont people 606: 604: 601: 599: 596: 594: 591: 589: 586: 584: 581: 579: 576: 574: 571: 569: 566: 564: 561: 560: 558: 545: 541: 540: 535: 530: 516: 515:azcentral.com 512: 506: 504: 495: 489: 485: 478: 476: 474: 472: 470: 468: 466: 464: 462: 446: 442: 436: 434: 419: 415: 408: 406: 404: 402: 393: 386: 381:|first1= 374: 366: 362: 358: 354: 350: 346: 339: 325: 321: 315: 313: 311: 296: 292: 286: 282: 274: 270: 264: 261: 258: 255: 252: 249: 246: 243: 240: 239: 233: 231: 227: 222: 220: 216: 211: 209: 205: 201: 197: 191: 189: 184: 182: 178: 174: 169: 167: 163: 159: 155: 151: 146: 144: 140: 136: 132: 128: 127:Orange, Texas 124: 114: 112: 111:Carl Djerassi 108: 104: 100: 96: 92: 88: 84: 80: 76: 72: 62: 60: 57: 53: 49: 45: 41: 37: 33: 29: 25: 21: 537: 529: 518:. Retrieved 514: 483: 449:. Retrieved 447:. 2021-09-24 444: 421:. Retrieved 417: 373:cite journal 348: 344: 338: 327:. Retrieved 323: 298:. Retrieved 294: 285: 271: 268: 223: 212: 192: 185: 170: 147: 120: 68: 51: 19: 18: 568:2021 deaths 563:1929 births 295:askican.org 236:Recognition 196:bryostatins 557:Categories 520:2022-01-03 451:2022-01-03 423:2022-01-03 329:2022-01-03 300:2022-01-03 277:References 365:0163-3864 208:lymphomas 177:Chemistry 173:Professor 166:professor 113:in 1956. 87:Chemistry 34:(SMS) at 28:Chemistry 24:Professor 445:ASU News 418:ASU News 219:h-index 215:patents 103:Steroid 30:in the 490:  363:  123:DuPont 117:Career 109:under 42:, and 89:from 488:ISBN 392:link 385:help 361:ISSN 353:doi 204:FDA 179:by 175:of 125:in 97:in 85:in 26:in 559:: 536:, 513:. 502:^ 460:^ 443:. 432:^ 416:. 400:^ 377:: 375:}} 371:{{ 359:. 349:71 347:. 322:. 309:^ 293:. 232:. 210:. 168:. 523:. 496:. 454:. 426:. 394:) 387:) 367:. 355:: 332:. 303:.

Index

Professor
Chemistry
School of Molecular Sciences
Arizona State University
American Society of Pharmacognosy
Washington State University
Journal of Natural Products
National Institutes of Health
National Cancer Institute
Long Branch, New Jersey
Long Branch High School
Monmouth University
Bachelor of Science
Chemistry
Washington State University
Master of Science
Heterocyclic Chemistry
Steroid
Wayne State University
Carl Djerassi
DuPont
Orange, Texas
Wayne State University
Norwich Pharmaceutical Company
Norwich, New York
central nervous system
University of Maine
National Cancer Institute
National Institutes of Health
University of Maine

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

↑