26:
937:
are engineered (synthetic) antibody mimetics based on a fibronectin type III domain (specifically, the 10th FN3 domain of human fibronectin). Monobodies feature either diversified loops or diversified strands of a flat beta-sheet surface, which serve as interaction epitopes. Monobody binders have
242:
present. Fibronectin domains are found in a wide variety of extracellular proteins. They are widely distributed in animal species, but also found sporadically in yeast, plant and bacterial proteins.
938:
been selected a wide variety of target molecules, and have expanded beyond the potential range of binding interfaces observed in both natural and synthetic antibodies.
186:
502:
702:
1106:
918:
798:
646:
274:
86:
1003:
Little E, Bork P, Doolittle RF (December 1994). "Tracing the spread of fibronectin type III domains in bacterial glycohydrolases".
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874:
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522:
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458:
270:
254:
682:
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610:
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518:
498:
482:
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470:
462:
450:
430:
310:
286:
914:
910:
802:
486:
478:
922:
110:
206:
1050:"Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene"
194:
230:
protein in which this domain was first identified contains 16 copies of this domain. The domain is about 100
350:
262:
190:
130:
123:
135:
91:
1101:
490:
426:
1012:
963:
173:
8:
850:
142:
1016:
967:
1065:
1036:
734:
1074:
1049:
1079:
1028:
991:
986:
951:
239:
181:
115:
1040:
54:
1069:
1061:
1020:
981:
971:
238:
structure. Of the three fibronectin-type domains, type III is the only one without
169:
67:
147:
79:
956:
Proceedings of the
National Academy of Sciences of the United States of America
223:
952:"Structural design and molecular evolution of a cytokine receptor superfamily"
1095:
235:
976:
1083:
1032:
995:
119:
227:
1024:
934:
866:
858:
266:
231:
103:
1047:
1048:
Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE (July 1985).
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730:
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98:
806:
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726:
658:
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650:
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25:
906:
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362:
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163:
61:
49:
446:
245:
1002:
1093:
226:that is widely found in animal proteins. The
24:
1073:
985:
975:
30:The tenth type III domain of fibronectin
1094:
949:
246:Human proteins containing this domain
13:
1107:Single-pass transmembrane proteins
1066:10.1002/j.1460-2075.1985.tb03847.x
14:
1118:
222:is an evolutionarily conserved
1005:Journal of Molecular Evolution
1:
942:
158:Available protein structures:
220:Fibronectin type III domain
7:
950:Bazan JF (September 1990).
928:
19:Fibronectin type III domain
10:
1123:
200:
180:
162:
157:
153:
141:
129:
109:
97:
85:
73:
60:
48:
40:
35:
23:
18:
977:10.1073/pnas.87.18.6934
234:long and possesses a
1017:1994JMolE..39..631L
968:1990PNAS...87.6934B
1025:10.1007/bf00160409
240:disulfide bonding
216:
215:
212:
211:
207:structure summary
1114:
1087:
1077:
1054:The EMBO Journal
1044:
999:
989:
979:
155:
154:
28:
16:
15:
1122:
1121:
1117:
1116:
1115:
1113:
1112:
1111:
1102:Protein domains
1092:
1091:
1090:
945:
931:
248:
31:
12:
11:
5:
1120:
1110:
1109:
1104:
1089:
1088:
1045:
1000:
962:(18): 6934–8.
946:
944:
941:
940:
939:
930:
927:
247:
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224:protein domain
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33:
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21:
20:
9:
6:
4:
3:
2:
1119:
1108:
1105:
1103:
1100:
1099:
1097:
1085:
1081:
1076:
1071:
1067:
1063:
1060:(7): 1755–9.
1059:
1055:
1051:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1011:(6): 631–43.
1010:
1006:
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988:
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628:
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292:
288:
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268:
264:
260:
256:
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243:
241:
237:
236:beta sandwich
233:
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205:
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108:
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100:
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93:
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88:
84:
81:
78:
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72:
69:
66:
63:
59:
56:
53:
51:
47:
43:
39:
34:
27:
22:
17:
1057:
1053:
1008:
1004:
959:
955:
249:
219:
217:
232:amino acids
228:fibronectin
36:Identifiers
1096:Categories
943:References
935:Monobodies
170:structures
143:Membranome
104:PDOC00214
80:IPR003961
1041:11909704
929:See also
919:dJ34F7.1
897:;
869:;
865:;
861:;
853:;
799:PTPsigma
649:;
493:;
449:;
353:;
275:C20orf75
269:;
265:;
187:RCSB PDB
75:InterPro
1084:2992939
1033:7528812
1013:Bibcode
996:2169613
964:Bibcode
917:;
913:;
873:;
849:;
837:;
833:;
829:;
805:;
737:;
731:PHYHIPL
725:;
705:;
673:;
645:;
641:;
605:;
589:;
577:;
565:;
543:IL12RB2
539:IL12RB1
489:;
481:;
429:;
365:;
359:DSCAML1
327:COL20A1
323:COL14A1
319:COL12A1
285:;
136:cd00063
99:PROSITE
55:PF00041
1082:
1075:554414
1072:
1039:
1031:
994:
984:
909:;
903:UMODL1
901:;
893:;
887:TRIM67
883:TRIM46
879:TRIM42
875:TRIM36
845:;
841:;
821:;
817:;
813:;
807:RIMBP2
795:PTPRZ1
789:;
785:;
781:;
777:;
773:;
769:;
765:;
757:;
753:;
749:;
745:;
739:PRODH2
727:PHYHIP
721:;
717:;
713:;
709:;
701:;
693:;
689:;
685:;
681:;
677:;
667:MYBPHL
659:MYBPC3
655:MYBPC2
651:MYBPC1
637:;
629:;
625:;
621:;
617:;
613:;
609:;
597:;
593:;
585:;
581:;
569:;
559:IL31RA
555:IL27RA
553:;
547:IL20RB
537:;
531:IL11RA
523:IGSF9B
521:;
515:IGSF22
513:;
507:IFNGR2
501:;
497:;
485:;
477:;
469:;
465:;
459:FNDC3B
455:FNDC3A
453:;
445:;
437:;
433:;
425:;
421:;
417:;
413:;
405:;
401:;
397:;
393:;
389:;
385:;
381:;
375:EPHA10
373:;
367:EGFLAM
357:;
349:;
343:CSF2RB
341:;
337:;
331:COL7A1
317:;
309:;
305:;
301:;
297:;
293:;
289:;
271:BZRAP1
261:;
255:ANKFN1
251:ABI3BP
202:PDBsum
176:
166:
124:SUPFAM
68:CL0159
41:Symbol
1037:S2CID
987:54656
907:USH2A
905:;
899:TYRO3
891:TRIM9
885:;
881:;
877:;
843:SORL1
839:SNED1
823:ROBO4
819:ROBO3
815:ROBO2
811:ROBO1
809:;
797:;
791:PTPRU
787:PTPRT
783:PTPRS
779:PTPRO
775:PTPRM
771:PTPRK
767:PTPRJ
763:PTPRH
759:PTPRG
755:PTPRF
751:PTPRD
747:PTPRC
743:PTPRB
741:;
719:OBSL1
715:OBSCN
711:NRCAM
707:NPHS1
699:NFASC
691:NCAM2
687:NCAM1
683:MYOM3
679:MYOM2
675:MYOM1
669:;
663:MYBPH
661:;
657:;
653:;
635:MERTK
631:LRRN3
627:LRRN1
623:LRIT1
619:LRFN5
615:LRFN4
611:LRFN3
607:LRFN2
595:L1CAM
591:KALRN
583:ITGB4
579:INSRR
567:IL6ST
561:;
557:;
551:IL23R
549:;
535:IL12B
533:;
519:IGSF9
517:;
511:IGF1R
509:;
499:HCFC2
495:HCFC1
483:FSD1L
475:FNDC8
471:FNDC7
467:FNDC5
463:FNDC4
461:;
457:;
451:FNDC1
443:FLRT3
439:FLRT2
435:FLRT1
431:FANK1
423:EPHB6
419:EPHB4
415:EPHB3
411:EPHB2
407:EPHB1
403:EPHA8
399:EPHA7
395:EPHA6
391:EPHA5
387:EPHA4
383:EPHA3
379:EPHA2
371:EPHA1
369:;
355:DSCAM
347:CSF3R
339:CRLF3
335:CRLF1
333:;
315:CNTN6
311:CNTN5
307:CNTN4
303:CNTN3
299:CNTN2
295:CNTN1
291:CNTFR
287:CMYA5
273:;
259:ASTN2
257:;
253:;
120:SCOPe
111:SCOP2
87:SMART
1080:PMID
1029:PMID
992:PMID
915:VWA1
911:VASN
871:TNXB
855:TIE1
847:SPEG
835:SDK2
831:SDK1
827:ROS1
803:PUNC
735:PRLR
733:;
723:OSMR
703:NOPE
695:NEO1
671:MYLK
643:MID2
639:MID1
603:LIFR
599:LEPR
587:KAL1
575:INSR
571:IL7R
563:IL6R
545:;
529:;
527:IL4R
503:HUGO
487:FSD2
479:FSD1
427:EPOR
363:EBI3
361:;
329:;
325:;
321:;
283:CHL1
279:CDON
218:The
195:PDBj
191:PDBe
174:ECOD
164:Pfam
116:1ttf
64:clan
62:Pfam
50:Pfam
1070:PMC
1062:doi
1021:doi
982:PMC
972:doi
923:fmi
895:TTN
867:TNR
863:TNN
859:TNC
851:TEK
801:;
647:MPL
491:GHR
447:FN1
351:DCC
277:;
267:BOC
263:AXL
182:PDB
131:CDD
92:FN3
44:fn3
1098::
1078:.
1068:.
1056:.
1052:.
1035:.
1027:.
1019:.
1009:39
1007:.
990:.
980:.
970:.
960:87
958:.
954:.
925:;
921:;
889:;
857:;
825:;
793:;
761:;
729:;
697:;
665:;
633:;
601:;
573:;
541:;
525:;
505:;
473:;
441:;
409:;
377:;
345:;
313:;
281:;
193:;
189:;
172:/
148:66
122:/
118:/
1086:.
1064::
1058:4
1043:.
1023::
1015::
998:.
974::
966::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
