529:
506:
51:
42:
2976:
1001:
Elimination: A single dose of a subcutaneous injection of enoxaparin has an elimination half-life of 4.5 hours. Approximately 10–40% of the active and inactive fragments from a single dose are excreted by the kidneys. Dose adjustments based on kidney function are necessary in persons with reduced
1889:
956:, or a past medical history of epidural or spinal punctures, spinal injury, or spinal deformations. The FDA recommends that at-risk persons be monitored for bleeding and neurological changes.
1705:"Drug Safety and Availability - FDA Drug Safety Communication: Updated recommendations to decrease risk of spinal column bleeding and paralysis in patients on low molecular weight heparins"
234:
739:, and distribution therefore monitoring is not typically done. However, there are instances where monitoring may be beneficial for special populations, for example individuals with
1882:
948:. It may be necessary to delay anticoagulant dosing in these persons in order to decrease the risk for spinal or epidural hematomas, which can manifest as permanent or long-term
2014:
1984:
1954:
1271:
1679:
1371:
1039:
In March 2017, Enoxaparin BECAT, Laboratorios ROVI (Spain) obtained marketing authorization in twenty six countries in Europe. The product is now available in Europe.
3006:
788:
per 1 mL as a preservative. Premature infants who have been given large amounts of benzyl alcohol (99–405 mg/kg/day) have experienced "gasping syndrome".
189:
583:
1078:
952:. Persons at risk for hematomas may present with indwelling epidural catheters, concurrent use of medications that worsen bleeding states such as
1739:
1239:
1036:
In
September 2016, Inhixa and Thorinane were approved for use in the European Union. Thorinane was withdrawn from the market in October 2019.
83:
78:
Arovi, Axberi, Axberi HP, Exarane, Exarane Forte, Enoxapo, Inclunox, Inclunox HP, Inhixa, Noromby, Noromby HP, Redesca, Redesca HP, Thorinane
1107:
2717:
2120:
2115:
1860:
998:
Metabolism: Enoxaparin is metabolized in the liver into low molecular weight species by either or both desulfation and depolymerization.
781:
Some fetal deaths have been reported by women who used enoxaparin during pregnancy, but it is unclear if enoxaparin caused these deaths.
2006:
1976:
1946:
1498:
1261:
720:
1409:
2816:
2054:
1827:
1454:
2146:
1671:
1712:
1363:
1304:
2032:
1921:
1570:
Gershanik J, Boecler B, Ensley H, McCloskey S, George W (November 1982). "The gasping syndrome and benzyl alcohol poisoning".
2930:
1795:
1770:
1548:
1180:
666:
590:
953:
1150:
134:
2301:
1492:
2947:
2097:
1010:
Enoxaparin belongs to the class of drugs known as low molecular weight heparins. Other drugs in this class include
836:
2911:
2319:
2292:
219:
115:
2703:
2246:
1607:"Reducing thrombotic complications in the perioperative setting: an update on heparin-induced thrombocytopenia"
2677:
378:
2047:
2530:
1883:"Public statement on Thorinane: Cessation of validity of the marketing authorisation in the European Union"
744:
659:
524:
425:
474:
2621:
2341:
1203:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
791:
Although enoxaparin is used to prevent blood clots, pregnancy alone can raise a woman's risk of clotting.
775:
B drug which means enoxaparin is not expected to cause harm to an unborn baby when used during pregnancy.
485:
1761:
Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, Jacobson PA, Kradjan WA, Williams BR (February 2012).
1068:
677:. In 2020, it was the 350th most commonly prescribed medication in the United States, with more than 500
2966:
17:
1735:
1231:
778:
Enoxaparin does not cross the placenta therefore it is unlikely an unborn baby would be exposed to it.
2669:
1854:
1512:
1403:
1202:
2040:
501:
940:
for enoxaparin in
October 2013. The revision recommends exercising caution regarding when spinal
2935:
624:
171:
63:
2062:
2284:
2208:
1115:
632:
178:
1849:
640:
2812:
1480:
695:
628:
369:
333:
2874:
2453:
2408:
1398:
647:
612:
434:
306:
8:
2264:
1811:
1450:
809:
740:
324:
93:
528:
505:
2555:
1636:
1623:
1606:
772:
670:
616:
145:
944:
are placed and removed in persons taking enoxaparin for spinal puncture or neuroaxial
2996:
2799:
2570:
2560:
2545:
2540:
2515:
2088:
2075:
2067:
1819:
1791:
1766:
1704:
1628:
1587:
1488:
1296:
984:(thrombin) compared to unfractionated heparin (UFH) due to its low molecular weight.
843:
755:
665:
Enoxaparin was first made in 1981 and approved for medical use in 1993. It is on the
263:
246:
107:
1640:
1045:
In
November 2020, Inclunox and Inclunox HP were approved for medical use in Canada.
2773:
2604:
2565:
2535:
1914:
1618:
1579:
1520:
832:
762:, with a maximum neutralization of approximately 60% of the anti-factor Xa effect.
541:
298:
202:
50:
1540:
1172:
1048:
In
December 2020, Redesca and Redesca HP were approved for medical use in Canada.
1042:
In
October 2020, Noromby and Noromby HP, were approved for medical use in Canada.
784:
The multiple-dose vials of the brand name enoxaparin (Lovenox) contain 15 mg
33:
3001:
2980:
2577:
736:
691:
651:
1583:
358:
2941:
2468:
2154:
2063:
785:
973:(a circulating anticoagulant) to form a complex that irreversibly inactivates
2990:
2898:
2868:
2458:
2443:
2438:
2399:
2071:
1266:
1142:
1073:
937:
920:
813:
636:
608:
517:
276:
995:
Distribution: Volume of distribution (anti-Factor Xa activity) = 4.3 liters
2888:
2858:
2836:
2831:
2804:
2753:
2732:
2582:
2521:
2477:
2354:
2297:
2236:
2231:
2212:
2110:
2079:
1823:
1632:
1517:
World Health
Organization model list of essential medicines: 21st list 2019
1015:
970:
915:
197:
1699:
1697:
1591:
2758:
2686:
2655:
2587:
2488:
2482:
2472:
2375:
2169:
2159:
1031:
974:
182:
101:
1525:
398:
2863:
2780:
2763:
2748:
2727:
2712:
2707:
2650:
2635:
2609:
2599:
2594:
2448:
2417:
2349:
2329:
2307:
2196:
2180:
2176:
2125:
1765:(Tenth ed.). Lippincott Williams & Wilkins. pp. 347–348.
1763:
Koda-Kimble and Young's
Applied Therapeutics: The Clinical Use of Drugs
1694:
1019:
1011:
981:
945:
853:
571:
409:
73:
623:
and following certain types of surgery. It is also used in those with
2851:
2846:
2826:
2821:
2768:
2722:
2696:
2691:
2640:
2498:
2421:
2385:
2359:
2324:
2312:
2274:
2269:
2259:
2221:
2191:
2186:
2164:
2130:
2105:
977:
949:
888:
817:
669:. Enoxaparin is sold under several brand names and is available as a
655:
620:
344:
87:
1485:
Neonatal
Formulary: Drug Use in Pregnancy and the First Year of Life
1297:"Clexane Forte Syringes - Summary of Product Characteristics (SmPC)"
806:
In people with unstable angina or non-Q-wave myocardial infarction:
2645:
2630:
2463:
2434:
2425:
2413:
2380:
2226:
941:
925:
910:
904:
873:
In persons with severely restricted mobility during acute illness:
650:. Bleeding may be serious especially in those who are undergoing a
454:
389:
129:
41:
2916:
2906:
2883:
2681:
2510:
2254:
876:
759:
699:
674:
2878:
1569:
865:
465:
1760:
2140:
726:
Bridging treatment for those with INR below therapeutic range
704:
DVT and pulmonary embolism prophylaxis in bed-ridden patients
1736:"Safety Information - Lovenox (enoxaparin sodium) injection"
992:
Absorption: Bioavailability (subcutaneous injection) ~ 100%
611:
medication (blood thinner). It is used to treat and prevent
490:
2785:
1143:"Enoxapo Australian prescription medicine decision summary"
445:
1977:"Summary Basis of Decision (SBD) for Inclunox/Inclunox HP"
1511:
1478:
1210:
2007:"Summary Basis of Decision (SBD) for Redesca/Redesca HP"
1947:"Summary Basis of Decision (SBD) for Noromby/Noromby HP"
1529:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
667:
1733:
1069:"Summary Basis of Decision (SBD) for Axberi/Axberi HP"
849:
In people undergoing abdominal or colorectal surgery:
758:
is less effective at reversing enoxaparin compared to
658:
appears to be safe for the baby. Enoxaparin is in the
2964:
1453:. The American Society of Health-System Pharmacists.
879:, thrombocytopenia, confusion, diarrhea, nausea: ≥ 2%
1785:
1370:. U.S. National Library of Medicine. 28 April 2020.
1358:
1356:
1354:
1352:
1350:
1348:
1346:
1344:
1342:
1291:
1289:
839:(0.5-5.0% of persons treated for at least five days)
1340:
1338:
1336:
1334:
1332:
1330:
1328:
1326:
1324:
1322:
1195:
716:
Treatment of DVT with or without pulmonary embolism
377:
1605:Levy JH, Tanaka KA, Hursting MJ (September 2007).
1604:
1165:
884:In people being treated for deep vein thrombosis:
1286:
747:can be measured and dosing adjusted accordingly.
646:Common side effects include bleeding, fever, and
2988:
1672:"ENOXAPARIN SODIUM- enoxaparin sodium injection"
1319:
887:Injection site hemorrhage, injection site pain,
357:
1137:
1135:
1133:
1102:
1100:
1098:
1096:
861:In persons undergoing hip or knee replacement:
332:
1842:
1393:
1391:
1389:
1262:"Summary Basis of Decision - Elonox/Elonox HP"
954:non-steroidal anti-inflammatory drugs (NSAIDs)
3007:World Health Organization essential medicines
2048:
1130:
1093:
1063:
1061:
133:
1666:
1664:
1662:
1660:
1658:
1656:
1654:
1652:
1650:
1445:
1443:
1441:
1439:
1437:
1435:
1433:
1431:
1429:
1427:
1386:
707:DVT prophylaxis in knee replacement surgery
2055:
2041:
1786:Trevor AJ, Katzung BG, Masters SB (2012).
1474:
1472:
721:ST-segment elevation myocardial infarction
710:DVT prophylaxis in hip replacement surgery
527:
504:
1915:"To The National Stock Market Commission"
1622:
1524:
1058:
903:Local reactions: local irritation, pain,
698:(NSTEMI), administered concurrently with
433:
1647:
1424:
27:Anticoagulant medication (blood thinner)
1709:Center for Drug Evaluation and Research
1505:
1469:
743:or those that are obese. In this case,
735:Enoxaparin has predictable absorption,
500:
397:
106:
14:
2989:
1501:from the original on 20 December 2016.
1364:"Lovenox- enoxaparin sodium injection"
1307:from the original on 26 September 2018
1236:Therapeutic Goods Administration (TGA)
1147:Therapeutic Goods Administration (TGA)
1112:Therapeutic Goods Administration (TGA)
964:
518:
285:
257:
2036:
1863:from the original on 30 December 2019
1738:. U.S. Food and Drug Administration.
1711:. U.S. Food and Drug Administration.
1678:. U.S. National Library of Medicine.
1519:. Geneva: World Health Organization.
1487:. John Wiley & Sons. p. 96.
1457:from the original on 21 December 2016
1153:from the original on 26 February 2020
1081:from the original on 24 February 2024
473:
270:
124:
92:
1715:from the original on 30 October 2015
1682:from the original on 19 October 2015
1551:from the original on 7 November 2022
1541:"Enoxaparin - Drug Usage Statistics"
1412:from the original on 29 October 2020
1183:from the original on 27 October 2020
713:DVT prophylaxis in abdominal surgery
201:
1927:from the original on 28 August 2021
1895:from the original on 28 August 2021
1830:from the original on 28 August 2015
1572:The New England Journal of Medicine
987:
453:
348:
24:
1624:10.1213/01.ane.0000277497.70701.47
1479:Northern Neonatal Network (2008).
1374:from the original on 4 August 2020
1274:from the original on 25 April 2023
1242:from the original on 31 March 2024
969:Enoxaparin binds to and activates
25:
3018:
1788:Basic & Clinical Pharmacology
1742:from the original on 4 March 2016
1173:"Enoxaparin Use During Pregnancy"
936:The FDA issued a revision to the
750:
719:Treatment of DVT inpatient, with
228:
156:
68:Lovenox, Clexane, Xaparin, others
2974:
2670:Direct thrombin (IIa) inhibitors
2098:Glycoprotein IIb/IIIa inhibitors
2017:from the original on 30 May 2022
1987:from the original on 30 May 2022
1957:from the original on 30 May 2022
931:
837:heparin-induced thrombocytopenia
49:
40:
2293:Thromboxane synthase inhibitors
1999:
1969:
1939:
1907:
1875:
1804:
1779:
1754:
1727:
1598:
1563:
1533:
1232:"AusPAR: Exarane/Exarane Forte"
1114:. 7 August 2023. Archived from
980:. It has less activity against
959:
868:, edema, peripheral edema: ≥ 2%
795:
684:
1254:
1224:
1025:
835:, i.e. can be associated with
241:
13:
1:
1051:
1005:
898:Frequency under investigation
730:
633:injection just under the skin
2531:Low-molecular-weight heparin
2342:Phosphodiesterase inhibitors
2255:Acetylsalicylic acid/Aspirin
1812:"LowMolecularWeightHeparins"
1734:Office of the Commissioner.
765:
660:low molecular weight heparin
603:, sold under the brand name
7:
1584:10.1056/NEJM198211253072206
673:. Enoxaparin is made from
10:
3023:
1029:
536:Chemical and physical data
2925:
2897:
2798:
2741:
2668:
2620:
2509:
2503:(with some II inhibition)
2497:
2407:
2398:
2368:
2340:
2283:
2245:
2207:
2139:
2096:
2087:
1855:European Medicines Agency
1513:World Health Organization
1404:European Medicines Agency
694:(UA) and non-ST elevated
639:. It is also used during
580:
576:4500 g/mol (average)
570:
540:
535:
516:
484:
464:
444:
424:
408:
388:
368:
343:
323:
318:
305:
297:
218:
213:
188:
170:
144:
114:
100:
82:
72:
62:
57:
48:
39:
1611:Anesthesia and Analgesia
681:thousand prescriptions.
1790:. McGraw-Hill Medical.
1108:"Exarane/Exarane Forte"
662:family of medications.
625:acute coronary syndrome
2813:Plasminogen activators
2285:Thromboxane inhibitors
2209:Prostaglandin analogue
907:, ecchymosis, erythema
690:Treatment of unstable
619:(PE) including during
2875:serine endopeptidases
2409:Vitamin K antagonists
1859:. 17 September 2018.
1408:. 17 September 2018.
696:myocardial infarction
2622:Direct Xa inhibitors
2454:Ethyl biscoumacetate
2320:Receptor antagonists
1149:. 28 February 2020.
842:Elevations in serum
771:Enoxaparin is a FDA
741:kidney insufficiency
648:swelling of the legs
613:deep vein thrombosis
607:among others, is an
2265:Carbasalate calcium
2013:. 23 October 2014.
1983:. 23 October 2014.
1953:. 23 October 2014.
1451:"Enoxaparin Sodium"
1077:. 26 January 2024.
965:Mechanism of action
810:Atrial fibrillation
266:(Prescription only)
237:(Prescription only)
36:
2952:Never to phase III
2800:Thrombolytic drugs
2516:glycosaminoglycans
2089:Antiplatelet drugs
2076:antiplatelet drugs
852:Bleeding, anemia,
773:pregnancy category
671:generic medication
617:pulmonary embolism
32:
2962:
2961:
2794:
2793:
2664:
2663:
2394:
2393:
1797:978-0-07-176401-8
1772:978-1-60913-713-7
1578:(22): 1384–1388.
1270:. 28 March 2023.
1118:on 2 January 2024
1002:kidney function.
844:aminotransferases
801:Uncommon (<1%)
756:Protamine sulfate
631:. It is given by
601:Enoxaparin sodium
598:
597:
486:CompTox Dashboard
289:
274:
261:
244:
232:
160:
127:
34:Enoxaparin sodium
16:(Redirected from
3014:
2979:
2978:
2977:
2970:
2774:Drotrecogin alfa
2754:Antithrombin III
2605:Dermatan sulfate
2578:Oligosaccharides
2507:
2506:
2405:
2404:
2141:ADP receptor/P2Y
2094:
2093:
2057:
2050:
2043:
2034:
2033:
2027:
2026:
2024:
2022:
2003:
1997:
1996:
1994:
1992:
1973:
1967:
1966:
1964:
1962:
1943:
1937:
1936:
1934:
1932:
1926:
1919:
1911:
1905:
1904:
1902:
1900:
1894:
1887:
1879:
1873:
1872:
1870:
1868:
1850:"Thorinane EPAR"
1846:
1840:
1839:
1837:
1835:
1816:livertox.nih.gov
1808:
1802:
1801:
1783:
1777:
1776:
1758:
1752:
1751:
1749:
1747:
1731:
1725:
1724:
1722:
1720:
1701:
1692:
1691:
1689:
1687:
1668:
1645:
1644:
1626:
1602:
1596:
1595:
1567:
1561:
1560:
1558:
1556:
1537:
1531:
1530:
1528:
1509:
1503:
1502:
1476:
1467:
1466:
1464:
1462:
1447:
1422:
1421:
1419:
1417:
1395:
1384:
1383:
1381:
1379:
1360:
1317:
1316:
1314:
1312:
1293:
1284:
1283:
1281:
1279:
1258:
1252:
1251:
1249:
1247:
1238:. 4 March 2024.
1228:
1222:
1221:
1219:
1217:
1207:nctr-crs.fda.gov
1199:
1193:
1192:
1190:
1188:
1179:. 15 July 2019.
1169:
1163:
1162:
1160:
1158:
1139:
1128:
1127:
1125:
1123:
1104:
1091:
1090:
1088:
1086:
1065:
988:Pharmacokinetics
833:Thrombocytopenia
680:
594:
593:
586:
531:
520:
509:
508:
494:
492:
477:
457:
437:
401:
381:
361:
351:
350:
336:
310:
287:
284:
279:
272:
269:
259:
256:
252:
243:
240:
230:
227:
205:
158:
155:
137:
126:
123:
110:
96:
53:
44:
37:
35:
31:
21:
3022:
3021:
3017:
3016:
3015:
3013:
3012:
3011:
2987:
2986:
2985:
2975:
2973:
2965:
2963:
2958:
2957:
2942:Clinical trials
2921:
2893:
2803:
2790:
2737:
2660:
2616:
2519:
2514:
2502:
2493:
2469:1,3-Indandiones
2411:
2390:
2364:
2336:
2279:
2241:
2203:
2155:Thienopyridines
2144:
2135:
2083:
2064:Antithrombotics
2061:
2031:
2030:
2020:
2018:
2005:
2004:
2000:
1990:
1988:
1975:
1974:
1970:
1960:
1958:
1945:
1944:
1940:
1930:
1928:
1924:
1917:
1913:
1912:
1908:
1898:
1896:
1892:
1885:
1881:
1880:
1876:
1866:
1864:
1848:
1847:
1843:
1833:
1831:
1810:
1809:
1805:
1798:
1784:
1780:
1773:
1759:
1755:
1745:
1743:
1732:
1728:
1718:
1716:
1703:
1702:
1695:
1685:
1683:
1670:
1669:
1648:
1603:
1599:
1568:
1564:
1554:
1552:
1539:
1538:
1534:
1510:
1506:
1495:
1477:
1470:
1460:
1458:
1449:
1448:
1425:
1415:
1413:
1397:
1396:
1387:
1377:
1375:
1362:
1361:
1320:
1310:
1308:
1295:
1294:
1287:
1277:
1275:
1260:
1259:
1255:
1245:
1243:
1230:
1229:
1225:
1215:
1213:
1201:
1200:
1196:
1186:
1184:
1171:
1170:
1166:
1156:
1154:
1141:
1140:
1131:
1121:
1119:
1106:
1105:
1094:
1084:
1082:
1067:
1066:
1059:
1054:
1034:
1028:
1008:
990:
967:
962:
934:
864:Fever, nausea,
827:Common (>1%)
798:
768:
753:
737:bioavailability
733:
687:
678:
589:
587:
584:(what is this?)
581:
565:
561:
557:
553:
549:
512:
488:
480:
460:
440:
420:
404:
384:
364:
347:
339:
308:
299:Pharmacokinetic
293:
277:
250:
209:
173:
166:
147:
140:
28:
23:
22:
15:
12:
11:
5:
3020:
3010:
3009:
3004:
2999:
2984:
2983:
2960:
2959:
2956:
2955:
2954:
2953:
2950:
2939:
2933:
2927:
2926:
2923:
2922:
2920:
2919:
2914:
2909:
2903:
2901:
2895:
2894:
2892:
2891:
2886:
2881:
2871:
2866:
2861:
2856:
2855:
2854:
2849:
2841:
2840:
2839:
2834:
2829:
2824:
2809:
2807:
2796:
2795:
2792:
2791:
2789:
2788:
2783:
2778:
2777:
2776:
2766:
2761:
2756:
2751:
2745:
2743:
2739:
2738:
2736:
2735:
2730:
2725:
2720:
2715:
2710:
2701:
2700:
2699:
2694:
2689:
2674:
2672:
2666:
2665:
2662:
2661:
2659:
2658:
2653:
2648:
2643:
2638:
2633:
2627:
2625:
2618:
2617:
2615:
2614:
2613:
2612:
2607:
2602:
2592:
2591:
2590:
2585:
2575:
2574:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2527:
2525:
2504:
2495:
2494:
2492:
2491:
2485:
2480:
2475:
2466:
2461:
2456:
2451:
2446:
2441:
2431:
2429:
2402:
2400:Anticoagulants
2396:
2395:
2392:
2391:
2389:
2388:
2383:
2378:
2372:
2370:
2366:
2365:
2363:
2362:
2357:
2352:
2346:
2344:
2338:
2337:
2335:
2334:
2333:
2332:
2327:
2317:
2316:
2315:
2310:
2305:
2289:
2287:
2281:
2280:
2278:
2277:
2272:
2267:
2262:
2257:
2251:
2249:
2247:COX inhibitors
2243:
2242:
2240:
2239:
2234:
2229:
2224:
2218:
2216:
2205:
2204:
2202:
2201:
2200:
2199:
2194:
2189:
2174:
2173:
2172:
2167:
2162:
2151:
2149:
2142:
2137:
2136:
2134:
2133:
2128:
2123:
2118:
2113:
2108:
2102:
2100:
2091:
2085:
2084:
2072:anticoagulants
2060:
2059:
2052:
2045:
2037:
2029:
2028:
1998:
1968:
1938:
1906:
1874:
1841:
1803:
1796:
1778:
1771:
1753:
1726:
1693:
1646:
1617:(3): 570–582.
1597:
1562:
1532:
1504:
1493:
1468:
1423:
1385:
1318:
1285:
1253:
1223:
1194:
1164:
1129:
1092:
1056:
1055:
1053:
1050:
1027:
1024:
1007:
1004:
989:
986:
966:
963:
961:
958:
933:
930:
929:
928:
923:
918:
913:
908:
895:
894:
893:
892:
882:
881:
880:
871:
870:
869:
859:
858:
857:
847:
840:
824:
823:
822:
821:
816:, lung edema,
797:
794:
793:
792:
789:
786:benzyl alcohol
782:
779:
776:
767:
764:
752:
751:Reversal agent
749:
732:
729:
728:
727:
724:
717:
714:
711:
708:
705:
702:
686:
683:
596:
595:
578:
577:
574:
568:
567:
563:
559:
555:
551:
547:
544:
538:
537:
533:
532:
522:
514:
513:
511:
510:
497:
495:
482:
481:
479:
478:
470:
468:
462:
461:
459:
458:
450:
448:
442:
441:
439:
438:
430:
428:
422:
421:
419:
418:
414:
412:
406:
405:
403:
402:
394:
392:
386:
385:
383:
382:
374:
372:
366:
365:
363:
362:
354:
352:
341:
340:
338:
337:
329:
327:
321:
320:
316:
315:
312:
303:
302:
295:
294:
292:
291:
282:
267:
254:
238:
224:
222:
216:
215:
211:
210:
208:
207:
194:
192:
186:
185:
176:
174:administration
168:
167:
165:
164:
162:
152:
150:
142:
141:
139:
138:
120:
118:
112:
111:
104:
98:
97:
90:
80:
79:
76:
70:
69:
66:
60:
59:
55:
54:
46:
45:
26:
9:
6:
4:
3:
2:
3019:
3008:
3005:
3003:
3000:
2998:
2995:
2994:
2992:
2982:
2972:
2971:
2968:
2951:
2949:
2946:
2945:
2943:
2940:
2937:
2934:
2932:
2929:
2928:
2924:
2918:
2915:
2913:
2910:
2908:
2905:
2904:
2902:
2900:
2899:Non-medicinal
2896:
2890:
2887:
2885:
2882:
2880:
2876:
2872:
2870:
2869:Streptokinase
2867:
2865:
2862:
2860:
2857:
2853:
2850:
2848:
2845:
2844:
2842:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2819:
2818:
2814:
2811:
2810:
2808:
2806:
2805:fibrinolytics
2801:
2797:
2787:
2784:
2782:
2779:
2775:
2772:
2771:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2746:
2744:
2740:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2705:
2702:
2698:
2695:
2693:
2690:
2688:
2685:
2684:
2683:
2679:
2676:
2675:
2673:
2671:
2667:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2628:
2626:
2623:
2619:
2611:
2608:
2606:
2603:
2601:
2598:
2597:
2596:
2593:
2589:
2586:
2584:
2581:
2580:
2579:
2576:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2533:
2532:
2529:
2528:
2526:
2523:
2517:
2512:
2508:
2505:
2500:
2496:
2490:
2486:
2484:
2481:
2479:
2476:
2474:
2470:
2467:
2465:
2462:
2460:
2459:Phenprocoumon
2457:
2455:
2452:
2450:
2447:
2445:
2444:Coumatetralyl
2442:
2440:
2439:Acenocoumarol
2436:
2433:
2432:
2430:
2427:
2423:
2419:
2415:
2410:
2406:
2403:
2401:
2397:
2387:
2384:
2382:
2379:
2377:
2374:
2373:
2371:
2367:
2361:
2358:
2356:
2353:
2351:
2348:
2347:
2345:
2343:
2339:
2331:
2328:
2326:
2323:
2322:
2321:
2318:
2314:
2311:
2309:
2306:
2303:
2299:
2296:
2295:
2294:
2291:
2290:
2288:
2286:
2282:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2258:
2256:
2253:
2252:
2250:
2248:
2244:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2219:
2217:
2214:
2210:
2206:
2198:
2195:
2193:
2190:
2188:
2185:
2184:
2182:
2178:
2175:
2171:
2168:
2166:
2163:
2161:
2158:
2157:
2156:
2153:
2152:
2150:
2148:
2145:
2138:
2132:
2129:
2127:
2124:
2122:
2119:
2117:
2114:
2112:
2109:
2107:
2104:
2103:
2101:
2099:
2095:
2092:
2090:
2086:
2081:
2077:
2073:
2069:
2068:thrombolytics
2065:
2058:
2053:
2051:
2046:
2044:
2039:
2038:
2035:
2016:
2012:
2011:Health Canada
2008:
2002:
1986:
1982:
1981:Health Canada
1978:
1972:
1956:
1952:
1951:Health Canada
1948:
1942:
1923:
1916:
1910:
1891:
1884:
1878:
1862:
1858:
1856:
1851:
1845:
1829:
1825:
1821:
1817:
1813:
1807:
1799:
1793:
1789:
1782:
1774:
1768:
1764:
1757:
1741:
1737:
1730:
1714:
1710:
1706:
1700:
1698:
1681:
1677:
1673:
1667:
1665:
1663:
1661:
1659:
1657:
1655:
1653:
1651:
1642:
1638:
1634:
1630:
1625:
1620:
1616:
1612:
1608:
1601:
1593:
1589:
1585:
1581:
1577:
1573:
1566:
1550:
1546:
1542:
1536:
1527:
1522:
1518:
1514:
1508:
1500:
1496:
1494:9780470750353
1490:
1486:
1482:
1475:
1473:
1456:
1452:
1446:
1444:
1442:
1440:
1438:
1436:
1434:
1432:
1430:
1428:
1411:
1407:
1405:
1400:
1399:"Inhixa EPAR"
1394:
1392:
1390:
1373:
1369:
1365:
1359:
1357:
1355:
1353:
1351:
1349:
1347:
1345:
1343:
1341:
1339:
1337:
1335:
1333:
1331:
1329:
1327:
1325:
1323:
1306:
1302:
1298:
1292:
1290:
1273:
1269:
1268:
1267:Health Canada
1263:
1257:
1241:
1237:
1233:
1227:
1212:
1208:
1204:
1198:
1182:
1178:
1174:
1168:
1152:
1148:
1144:
1138:
1136:
1134:
1117:
1113:
1109:
1103:
1101:
1099:
1097:
1080:
1076:
1075:
1074:Health Canada
1070:
1064:
1062:
1057:
1049:
1046:
1043:
1040:
1037:
1033:
1023:
1021:
1017:
1013:
1003:
999:
996:
993:
985:
983:
979:
976:
972:
957:
955:
951:
947:
943:
939:
938:boxed warning
932:Boxed warning
927:
924:
922:
921:Transaminitis
919:
917:
914:
912:
909:
906:
902:
901:
900:
899:
890:
886:
885:
883:
878:
875:
874:
872:
867:
863:
862:
860:
855:
851:
850:
848:
845:
841:
838:
834:
831:
830:
829:
828:
819:
815:
814:heart failure
811:
808:
807:
805:
804:
803:
802:
790:
787:
783:
780:
777:
774:
770:
769:
763:
761:
757:
748:
746:
745:anti-Xa units
742:
738:
725:
722:
718:
715:
712:
709:
706:
703:
701:
697:
693:
689:
688:
682:
676:
672:
668:
663:
661:
657:
654:. Use during
653:
649:
644:
642:
638:
634:
630:
629:heart attacks
626:
622:
618:
614:
610:
609:anticoagulant
606:
602:
592:
585:
579:
575:
573:
569:
545:
543:
539:
534:
530:
526:
523:
521:
519:ECHA InfoCard
515:
507:
503:
502:DTXSID0045969
499:
498:
496:
487:
483:
476:
475:ChEMBL1201685
472:
471:
469:
467:
463:
456:
452:
451:
449:
447:
443:
436:
432:
431:
429:
427:
423:
416:
415:
413:
411:
407:
400:
396:
395:
393:
391:
387:
380:
376:
375:
373:
371:
367:
360:
356:
355:
353:
346:
342:
335:
331:
330:
328:
326:
322:
317:
313:
311:
304:
300:
296:
290: Rx-only
283:
280:
268:
265:
255:
248:
239:
236:
226:
225:
223:
221:
217:
212:
204:
199:
196:
195:
193:
191:
187:
184:
180:
177:
175:
169:
163:
154:
153:
151:
149:
143:
136:
131:
122:
121:
119:
117:
113:
109:
105:
103:
99:
95:
91:
89:
85:
81:
77:
75:
71:
67:
65:
61:
58:Clinical data
56:
52:
47:
43:
38:
30:
19:
2889:Fibrinolysin
2859:Anistreplase
2837:Desmoteplase
2832:Tenecteplase
2733:Ximelagatran
2583:Fondaparinux
2550:
2522:antithrombin
2478:Diphenadione
2355:Dipyridamole
2298:Dipyridamole
2237:Treprostinil
2232:Prostacyclin
2111:Eptifibatide
2019:. Retrieved
2010:
2001:
1989:. Retrieved
1980:
1971:
1959:. Retrieved
1950:
1941:
1929:. Retrieved
1909:
1897:. Retrieved
1877:
1865:. Retrieved
1853:
1844:
1832:. Retrieved
1815:
1806:
1787:
1781:
1762:
1756:
1744:. Retrieved
1729:
1717:. Retrieved
1708:
1684:. Retrieved
1675:
1614:
1610:
1600:
1575:
1571:
1565:
1553:. Retrieved
1544:
1535:
1526:10665/325771
1516:
1507:
1484:
1481:"Enoxaparin"
1459:. Retrieved
1414:. Retrieved
1402:
1376:. Retrieved
1367:
1309:. Retrieved
1300:
1276:. Retrieved
1265:
1256:
1244:. Retrieved
1235:
1226:
1214:. Retrieved
1206:
1197:
1185:. Retrieved
1176:
1167:
1155:. Retrieved
1146:
1120:. Retrieved
1116:the original
1111:
1083:. Retrieved
1072:
1047:
1044:
1041:
1038:
1035:
1016:fondaparinux
1009:
1000:
997:
994:
991:
971:antithrombin
968:
960:Pharmacology
935:
916:Hyperkalemia
897:
896:
826:
825:
800:
799:
796:Side effects
754:
734:
685:Medical uses
664:
645:
641:hemodialysis
604:
600:
599:
588:
582:
307:Elimination
220:Legal status
214:Legal status
179:Subcutaneous
116:License data
29:
2938:from market
2759:Defibrotide
2687:Bivalirudin
2656:Rivaroxaban
2595:Heparinoids
2588:Idraparinux
2489:Tioclomarol
2483:Phenindione
2473:Clorindione
2376:Cloricromen
2170:Ticlopidine
2160:Clopidogrel
1085:24 February
1032:Biosimilars
1026:Biosimilars
846:: 5.9%-6.1%
637:into a vein
525:100.029.698
334:679809-58-6
319:Identifiers
183:intravenous
102:MedlinePlus
74:Biosimilars
64:Trade names
2991:Categories
2864:Monteplase
2781:Ramatroban
2764:Nafamostat
2749:Abelacimab
2728:Melagatran
2713:Dabigatran
2708:Argatroban
2651:Otamixaban
2636:Betrixaban
2624:("xabans")
2610:Sulodexide
2600:Danaparoid
2571:Tinzaparin
2561:Parnaparin
2556:Nadroparin
2551:Enoxaparin
2546:Dalteparin
2541:Certoparin
2501:inhibitors
2449:Dicoumarol
2350:Cilostazol
2330:Terutroban
2308:Picotamide
2197:Ticagrelor
2181:nucleoside
2177:Nucleotide
2147:inhibitors
2126:Sibrafiban
1834:5 November
1746:5 November
1719:5 November
1686:5 November
1461:8 December
1311:12 October
1216:22 October
1052:References
1030:See also:
1020:tinzaparin
1012:dalteparin
1006:Drug class
982:factor IIa
946:anesthesia
926:Hemorrhage
854:ecchymosis
820:: ≥ 0.5%v
731:Monitoring
652:spinal tap
627:(ACS) and
615:(DVT) and
572:Molar mass
435:8NZ41MIK1O
410:ChemSpider
370:IUPHAR/BPS
325:CAS Number
253:Schedule D
135:Enoxaparin
18:Enoxaparin
2948:Phase III
2936:Withdrawn
2852:Urokinase
2847:Saruplase
2827:Reteplase
2822:Alteplase
2769:Protein C
2723:Inogatran
2718:Efegatran
2704:Univalent
2697:Lepirudin
2692:Desirudin
2641:Darexaban
2566:Reviparin
2536:Bemiparin
2499:Factor Xa
2435:Coumarins
2412:(inhibit
2386:Vorapaxar
2360:Triflusal
2325:Terbogrel
2313:Terbogrel
2302:+ aspirin
2275:Triflusal
2270:Indobufen
2260:Aloxiprin
2222:Beraprost
2192:Elinogrel
2187:Cangrelor
2165:Prasugrel
2131:Tirofiban
2121:Roxifiban
2116:Orbofiban
2106:Abciximab
1555:7 October
1378:16 August
1187:16 August
1177:Drugs.com
1157:17 August
978:factor Xa
950:paralysis
942:catheters
889:hematuria
818:pneumonia
766:Pregnancy
656:pregnancy
621:pregnancy
314:4.5 hours
309:half-life
172:Routes of
146:Pregnancy
94:Monograph
88:Drugs.com
2997:Heparins
2981:Medicine
2678:Bivalent
2646:Edoxaban
2631:Apixaban
2464:Warfarin
2381:Ditazole
2227:Iloprost
2183:analogs
2015:Archived
1985:Archived
1955:Archived
1922:Archived
1890:Archived
1861:Archived
1828:Archived
1824:31643176
1818:. 2012.
1740:Archived
1713:Archived
1680:Archived
1676:DailyMed
1641:25103749
1633:17717208
1549:Archived
1545:ClinCalc
1515:(2019).
1499:Archived
1455:Archived
1410:Archived
1372:Archived
1368:DailyMed
1305:Archived
1278:24 April
1272:Archived
1246:31 March
1240:Archived
1181:Archived
1151:Archived
1079:Archived
975:clotting
911:Bleeding
905:hematoma
591:(verify)
390:DrugBank
190:ATC code
148:category
130:DailyMed
2917:Oxalate
2907:Citrate
2884:Brinase
2682:Hirudin
2511:Heparin
2487:Other:
1899:2 April
1867:2 April
1592:7133084
1416:2 April
877:Dyspnea
760:heparin
723:(STEMI)
700:aspirin
675:heparin
605:Lovenox
542:Formula
399:DB01225
345:PubChem
281:Rx-only
278:WARNING
249: /
245::
206:)
200: (
198:B01AB05
161: C
132::
108:a696006
3002:Sanofi
2967:Portal
2931:WHO-EM
2879:Ancrod
2873:Other
2520:(bind
2513:group/
2021:29 May
1991:29 May
1961:29 May
1931:29 May
1822:
1794:
1769:
1639:
1631:
1590:
1491:
1122:4 July
891:: ≥ 2%
866:anemia
856:: ≥ 2%
692:angina
679:
466:ChEMBL
455:D07510
275:
262:
251:
247:℞-only
233:
128:
2817:r-tPA
2742:Other
2369:Other
1925:(PDF)
1918:(PDF)
1893:(PDF)
1886:(PDF)
1857:(EMA)
1637:S2CID
1406:(EMA)
2912:EDTA
2843:UPA
2786:REG1
2213:PGI2
2074:and
2023:2022
1993:2022
1963:2022
1933:2020
1901:2020
1869:2020
1836:2015
1820:PMID
1792:ISBN
1767:ISBN
1748:2015
1721:2015
1688:2015
1629:PMID
1588:PMID
1557:2022
1489:ISBN
1463:2016
1418:2020
1380:2020
1313:2020
1280:2023
1248:2024
1218:2023
1189:2020
1159:2020
1124:2024
1087:2024
1018:and
446:KEGG
426:UNII
417:none
379:6811
301:data
84:AHFS
2418:VII
2080:B01
2078:) (
1619:doi
1615:105
1580:doi
1576:307
1521:hdl
1301:emc
1211:FDA
635:or
491:EPA
359:772
349:CID
264:POM
203:WHO
2993::
2944::
2877::
2815::
2706::
2680::
2471::
2437::
2424:,
2422:IX
2420:,
2416:,
2414:II
2143:12
2070:,
2009:.
1979:.
1949:.
1920:.
1888:.
1852:.
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1071:.
1060:^
1022:.
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812:,
643:.
566:)n
560:36
552:40
548:26
546:(C
286:EU
271:US
258:UK
242:CA
235:S4
229:AU
181:,
157:AU
125:US
2969::
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2524:)
2518:/
2428:)
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558:O
556:2
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