1213:: it can be used in adults and children. For treatment or prophylaxis of Lyme disease in children, it can be used for a duration of up to 21 days in children of any age. Doxycycline is specifically indicated to treat Lyme disease for patients presenting with erythema migrans. As for the optimal duration of treatment of this disease, guidelines vary, with some recommending a 10-day course of doxycycline, while others suggest a 14-day course; still, recent data suggest that even a 7-day course of doxycycline can be effective. Compared to other drugs, there are no significant differences in treatment response across antibiotic agents, doses, or durations when comparing 14 days versus 21 days; as such, the optimal duration of treatment of Lyme disease remains uncertain, as prolonged antibiotic courses have drawbacks, including diminishing returns in terms of patient outcomes, heightened risks of adverse events, superinfections, increased healthcare costs, and the potential for development of antibiotic resistance. Therefore, the consensus remains to treat patients with the shortest effective duration of antibiotics, as is the case with doxycycline for Lyme disease as well.
1804:. Other tetracycline antibiotics are contraindicated in pregnancy and up to eight years of age, due to the potential for disrupting bone and tooth development. They include a class warning about staining of teeth and decreased development of dental enamel in children exposed to tetracyclines in utero, during breastfeeding or during young childhood. However, the FDA has acknowledged that the actual risk of dental staining of primary teeth is undetermined for doxycycline specifically. The best available evidence indicates that doxycycline has little or no effect on hypoplasia of dental enamel or on staining of teeth and the
2308:
648:
625:
897:
31:
905:
40:
1760:
of doxycycline by 20%. Doxycycline absorption is also inhibited by divalent and trivalent cations, such as iron, bismuth, aluminum, calcium and magnesium. Doxycycline forms unstable complexes with metal ions in the acidic gastric environment, which dissociate in the small intestine, allowing the drug to be absorbed. However, some doxycycline remains complexed with metal ions in the duodenum, resulting in a slight decrease in absorption.
1573:—such blocking leads to two main effects: it disrupts the parasite's ability to produce fatty acids, which are essential for its growth, and it impairs the production of heme, a cofactor. These effects occur late in the parasite's life cycle when it is in the blood stage, causing the symptoms of malaria. By blocking important processes in the parasite, doxycycline both inhibits the growth and prevents the multiplication of
11001:
1509:. For this reason, the Australian consensus statement mentions that doxycycline for PEP particularly in gay, bisexual, and other men who have sex with men (GBMSM) should be considered only for the prevention of syphilis in GBMSM, and that the risk of increasing antimicrobial resistance outweighed any potential benefit from reductions in other bacterial STIs in GBMSM.
1912:. Doxycycline–metal ion complexes are unstable at acid pH, therefore more doxycycline enters the duodenum for absorption than the earlier tetracycline compounds. In addition, food has less effect on absorption than on absorption of earlier drugs with doxycycline serum concentrations being reduced by about 20% by test meals compared with 50% for tetracycline.
2390:. However, there is no clear understanding of what contributes more: the bacteriostatic properties of doxycycline, which affect bacteria (such as Propionibacterium acnes) on the surface of sebaceous glands even in lower doses called "submicrobial" or "subantimicrobial", or whether doxycycline's anti-inflammatory effects, which reduce inflammation in
6321:
2270:. The shortage came at a particularly bad time, since there were also shortages of an alternative antibiotic, tetracycline, at the same time. The market price for doxycycline dramatically increased in the United States in 2013 and early 2014 (from $ 20 to over $ 1800 for a bottle of 500 tablets), before decreasing again.
2533:
Research on novel drug formulations for the delivery of doxycycline in wound treatment is expanding, focusing on overcoming stability limitations for long-term storage and developing consumer-friendly, parenteral antibiotic delivery systems. The most common and practical form of doxycycline delivery
2378:
Doxycycline also inhibits allikrein-related peptidase 5 (KLK5). The inhibition of MMPs and KLK5 enzymes subsequently suppresses the expression of LL-37, a cathelicidin antimicrobial peptide that, when overexpressed, can trigger inflammatory cascades. By inhibiting LL-37 expression, doxycycline helps
1903:
Doxycycline is highly lipophilic, so it can easily enter cells, meaning the drug is easily absorbed after oral administration and has a large volume of distribution. It can also be re-absorbed in the renal tubules and gastrointestinal tract due to its high lipophilicity, giving it a long elimination
1759:
Doxycycline has a high oral bioavailability, as it is almost completely absorbed in the stomach and proximal small intestine. Unlike other tetracyclines, its absorption is not significantly affected by food or dairy intake. However, co-administration of dairy products reduces the serum concentration
2537:
Research directions on the use of doxycycline in wound healing include the continuous stabilization of doxycycline, scaling up technology and industrial production, and exploring non-contact wound treatment methods like sprays and aerosols for use in emergencies and when medical care is not readily
2406:
effect, especially when taken for extended periods, such as several months in treating acne and rosacea. While the SDD is believed to have anti-inflammatory effects rather than solely antibacterial effects, SDD was proven to work by reducing inflammation associated with acne and rosacea. Still, the
1924:
antibiotic. It inhibits the synthesis of bacterial proteins by binding to the 30S ribosomal subunit, which is only found in bacteria. This prevents the binding of transfer RNA to messenger RNA at the ribosomal subunit meaning amino acids cannot be added to polypeptide chains and new proteins cannot
1846:
rash in sun-exposed parts of the body has been reported to occur in 7.3–21.2% of persons taking doxycycline for malaria prophylaxis. One study examined the tolerability of various malaria prophylactic regimens and found doxycycline did not cause a significantly higher percentage of all skin events
7155:
Mello BSF, Chaves Filho AJM, Custódio CS, Rodrigues PA, Carletti JV, Vasconcelos SMM, et al. (September 2021). "Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of
2524:
infection, but the trials did not demonstrate the expected benefit. Researchers also believed that doxycycline possesses anti-inflammatory and immunomodulatory effects that could reduce the production of cytokines in COVID-19, but these supposed effects failed to improve the outcome of COVID-19
6317:
1481:
published in 2011. SDD is also used to treat skin conditions such as acne and rosacea, including ocular rosacea. In ocular rosacea, treatment period is 2 to 3 months. After discontinuation of doxycycline, recurrences may occur within three months; therefore, many studies recommend either slow
1881:
induction. Research has shown no significant loss of effectiveness in oral contraceptives while using most tetracycline antibiotics (including doxycycline), although many physicians still recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy.
717:
2241:
itself, the first semi-synthetic antibiotic. Charlie
Stephens' group at Pfizer worked on further analogs and created one with greatly improved stability and pharmacological efficacy: doxycycline. It was clinically developed in the early 1960s and approved by the FDA in 1967.
2249:
that was not resolved until 1983; at the time it was the largest litigated patent case in US history. Instead of a cash payment for infringement, Pfizer took the veterinary and feed-additive businesses of
International Rectifier's subsidiary, Rachelle Laboratories.
2442:. Nevertheless, current results are inconclusive, and evidence of doxycycline's anti-inflammatory properties needs to be improved, considering conflicting reports from animal models so far. Doxycycline has been studied in various immunological disorders, including
4983:
Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, et al. (November 2003). "Doxycycline as a novel strategy against bancroftian filariasis-depletion of
Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production".
8135:
Leyder E, Suresh P, Jun R, Overbey K, Banerjee T, Melnikova T, et al. (February 2023). "Depression-related phenotypes at early stages of Aβ and tau accumulation in inducible
Alzheimer's disease mouse model: Task-oriented and concept-driven interpretations".
2004:. In the case of doxycycline, the absence of a hydroxyl group in C-6 prevents the formation of the nephrotoxic compound. Nevertheless, tetracyclines and doxycycline itself have to be taken with caution in patients with kidney injury, as they can worsen
2253:
In
January 2013, the FDA reported shortages of some, but not all, forms of doxycycline "caused by increased demand and manufacturing issues". Companies involved included an unnamed major generics manufacturer that ceased production in February 2013,
4031:
Okada T, Morozumi M, Tajima T, Hasegawa M, Sakata H, Ohnari S, et al. (December 2012). "Rapid effectiveness of minocycline or doxycycline against macrolide-resistant
Mycoplasma pneumoniae infection in a 2011 outbreak among Japanese children".
2566:. The mechanism of action for the antibacterial effect of tetracyclines relies on disrupting protein translation in bacteria, thereby damaging the ability of microbes to grow and repair; however protein translation is also disrupted in eukaryotic
2232:
and it was brought to market. Both compounds, like penicillin, were natural products and it was commonly believed that nature had perfected them, and further chemical changes could only degrade their effectiveness. Scientists at Pfizer led by
6852:
García RA, Pantazatos DP, Gessner CR, Go KV, Woods VL, Villarreal FJ (April 2005). "Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry".
1504:
Doxycycline is used for post-exposure prophylaxis (PEP) to reduce the incidence of sexually transmitted bacterial infections (STIs), but it has been associated with tetracycline resistance in associated species, in particular, in
2454:. In these conditions, doxycycline has been researched to determine anti-inflammatory and immunomodulatory effects that could be beneficial in treating these conditions. However, a solid conclusion still needs to be provided.
4252:
Sgolastra F, Petrucci A, Gatto R, Giannoni M, Monaco A (November 2011). "Long-term efficacy of subantimicrobial-dose doxycycline as an adjunctive treatment to scaling and root planing: a systematic review and meta-analysis".
1477:. Significant differences were observed for all investigated clinical parameters of periodontitis in favor of the scaling and root planing + SDD group where SDD dosage regimens is 20 mg twice daily for three months in a
4391:
Avraham S, Khaslavsky S, Kashetsky N, Starkey SY, Zaslavsky K, Lam JM, et al. (February 2024). "Therapie der okulären
Rosazea: Eine systematische Literatur-Übersicht: Treatment of ocular rosacea: a systematic review".
3025:
Sweet RL, Schachter J, Landers DV, Ohm-Smith M, Robbie MO (March 1988). "Treatment of hospitalized patients with acute pelvic inflammatory disease: comparison of cefotetan plus doxycycline and cefoxitin plus doxycycline".
2427:. It is observed that doxycycline exerts its anti-inflammatory effects by inhibiting neutrophil chemotaxis and oxidative bursts, which are common mechanisms involved in inflammation and ROS activity in rosacea and acne.
5638:
Lee TW, Russell L, Deng M, Gibson PR (August 2013). "Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in
Australians deployed abroad".
4124:
Roca Mora MM, Cunha LM, Godoi A, Donadon I, Clemente M, Marcolin P, et al. (June 2024). "Shorter versus longer duration of antimicrobial therapy for early Lyme disease: A systematic review and meta-analysis".
944:
infections. The efficiency of oral doxycycline for treating papulopustular rosacea and adult acne is not solely based on its antibiotic properties, but also on its anti-inflammatory and anti-angiogenic properties.
3983:
5027:
Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A (2005). "Macrofilaricidal activity after doxycycline treatment of
Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial".
759:
InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
6223:
4589:"Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men"
2423:, helping minimize tissue damage caused by highly oxidative and inflammatory conditions. Studies have shown that SDD can effectively improve acne and rosacea symptoms, probably without inducing
7651:
Waitayangkoon P, Moon SJ, Tirupur
Ponnusamy JJ, Zeng L, Driban J, McAlindon T (September 2023). "Long-Term Safety Profiles Macrolides and Tetracyclines: A Systematic Review and Meta-analysis".
8605:
Dursun D, Kim MC, Solomon A, Pflugfelder SC (July 2001). "Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids".
5682:
Margolis DJ, Fanelli M, Hoffstad O, Lewis JD (December 2010). "Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease".
4659:"2023 Consensus Statement on doxycycline prophylaxis (Doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual, and other men who have sex with men in Australia"
4697:
3158:
Määttä M, Kari O, Tervahartiala T, Peltonen S, Kari M, Saari M, et al. (August 2006). "Tear fluid levels of MMP-8 are elevated in ocular rosacea--treatment effect of oral doxycycline".
3534:
Karlsson M, Hammers-Berggren S, Lindquist L, Stiernstedt G, Svenungsson B (July 1994). "Comparison of intravenous penicillin G and oral doxycycline for treatment of Lyme neuroborreliosis".
2344:(IL-10). Cytokines are small proteins that are secreted by immune cells and play a key role in the immune response. Some studies suggest that doxycycline can suppress the activation of the
2000:
Expired tetracyclines or tetracyclines allowed to stand at a pH less than 2 are reported to be nephrotoxic due to the formation of a degradation product, anhydro-4-epitetracycline causing
865:. Use during pregnancy is not recommended. Like other agents of the tetracycline class, it either slows or kills bacteria by inhibiting protein production. It kills malaria by targeting a
8221:"Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial"
8041:
do Amaral L, Dos Santos NAG, Sisti FM, Del Bel E, Dos Santos AC (August 2023). "Doxycycline inhibits dopaminergic neurodegeneration through upregulation of axonal and synaptic proteins".
1828:, particularly when it is swallowed without adequate fluid, or by persons with difficulty swallowing or impaired mobility. Doxycycline is less likely than other antibiotic drugs to cause
1001:. Additionally, doxycycline is used in the prevention and treatment of serious conditions like anthrax, leptospirosis, bubonic plague, and Lyme disease. However, some bacteria, including
3324:
2516:(NICE) updated its guidance to not recommend the medication for the treatment of COVID‑19. Doxycycline was expected to possess anti-inflammatory properties that could lessen the
1988:
is 18 to 22 hours (16 ± 6 hours according to another source) in healthy people, slightly longer in those with end-stage kidney disease, and significantly longer in those with
3919:"Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis — United States"
1331:
strains developed resistance to doxycycline. When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by
293:
8950:
2497:
cells. However, the involvement of this mechanism in the neuroprotective effect of doxycycline is unknown. Doxycycline is also studied in reverting inflammatory changes related to
6270:
3201:
Quarterman MJ, Johnson DW, Abele DC, Lesher JL, Hull DS, Davis LS (January 1997). "Ocular rosacea. Signs, symptoms, and tear studies before and after treatment with doxycycline".
6295:
3401:
Nadelman RB, Luger SW, Frank E, Wisniewski M, Collins JJ, Wormser GP (August 1992). "Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease".
3379:
1558:. It is not recommended alone for initial treatment of malaria, even when the parasite is doxycycline-sensitive, because the antimalarial effect of doxycycline is delayed.
5335:
4780:
2415:
by inflammatory cells; these ROS contribute toward exacerbating symptoms. Doxycycline may reduce ROS levels and induce antioxidant activity because it directly scavenges
3971:
4810:
2076:
6245:
1976:
is negligible. It is actively excreted into the gut (in part via the gallbladder, in part directly from blood vessels), where some of it is inactivated by forming
10290:
6231:
8270:"Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review"
11051:
4160:
Dreno B, Thiboutot D, Gollnick H, Bettoli V, Kang S, Leyden JJ, et al. (2014). "Antibiotic stewardship in dermatology: limiting antibiotic use in acne".
8943:
8663:
2430:
Doxycycline's dual benefits as an antibacterial and anti-inflammatory make it a helpful treatment option for diseases involving inflammation not only of the
238:
2562:
biomedical research experiments involving bacteria as well in experiments in eukaryotic cells and organisms with inducible protein expression systems using
1588:(WHO) guidelines state that the combination of doxycycline with either artesunate or quinine may be used for the treatment of uncomplicated malaria due to
8197:
6201:
6179:
6135:
6110:
3803:
3712:
977:
Doxycycline is a broad-spectrum antibiotic that is employed in the treatment of numerous bacterial infections. It is effective against bacteria such as
2579:
2563:
1641:
Doxycycline has been used successfully to treat sexually transmitted, respiratory, and ophthalmic infections. Representative pathogenic genera include
775:
9802:
6351:
2513:
8936:
5835:"Pharmacodynamics of doxycycline and tetracycline against Staphylococcus pseudintermedius: proposal of canine-specific breakpoints for doxycycline"
4750:
4721:"Comparison of doxycycline-streptomycin, doxycycline-rifampin, and ofloxacin-rifampin in the treatment of brucellosis: a randomized clinical trial"
4689:
1741:, doxycyclin appears to be a promising combination capable of disrupting transthyretine TTR fibrils in existing amyloid deposits of ATTR patients.
7103:"Efficacy of Subantimicrobial, Modified-Release Doxycycline Compared to Regular-Release Doxycycline for the Treatment of Hidradenitis Suppurativa"
5211:
2320:
Some studies show doxycycline as a potential agent to possess anti-inflammatory properties acting by inhibiting proinflammatory cytokines such as
2489:(PD). Therefore, the regeneration of the axonal and synaptic network might be beneficial in PD. It has been demonstrated that doxycycline mimics
2212:
revolutionized the treatment of bacterial infections in World War II, many chemical companies moved into the field of discovering antibiotics by
9879:
8562:
Gossen M, Freundlieb S, Bender G, Müller G, Hillen W, Bujard H (June 1995). "Transcriptional activation by tetracyclines in mammalian cells".
4636:
4516:
3312:
132:
7847:"Repurposing tetracyclines for acute respiratory distress syndrome (ARDS) and severe COVID-19: a critical discussion of recent publications"
4458:"45 years of tetracycline post exposure prophylaxis for STIs and the risk of tetracycline resistance: a systematic review and meta-analysis"
10367:
10097:
6898:"Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders"
2402:, contribute more to its therapeutic effectiveness against these skin conditions. Subantimicrobial-dose doxycycline (SDD) can still have a
731:
3338:
3160:
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
10283:
2892:
1359:
1222:
When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by
6280:
5089:
1805:
1513:
2481:
proteins. Axonal degeneration and synaptic loss are key events at the early stages of neurodegeneration and precede neuronal death in
8656:
7385:"Effect of doxycycline on the generation of reactive oxygen species: a possible mechanism of action of acne therapy with doxycycline"
3236:
Walker DH, Paddock CD, Dumler JS (November 2008). "Emerging and re-emerging tick-transmitted rickettsial and ehrlichial infections".
2638:
6303:
10027:
3903:
3446:"Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans"
3371:
8422:"Development strategy of novel drug formulations for the delivery of doxycycline in the treatment of wounds of various etiologies"
8928:
6373:
3948:
3604:
Karlsson U, Bjöersdorff A, Massung RF, Christensson B (2001). "Human granulocytic ehrlichiosis--a clinical case in Scandinavia".
7747:"Doxycycline aggravates granulomatous inflammation and lung microstructural remodeling induced by Schistosoma mansoni infection"
6020:
5327:
4772:
4666:
10276:
7553:"Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model"
2379:
to mitigate these downstream inflammatory cascades, thereby reducing inflammation and the symptoms of inflammatory conditions.
10268:
6653:"Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines"
6518:
10955:
10234:
9795:
9746:
6921:
6635:
6076:
5971:
5814:
5420:
5123:
4967:
4802:
2978:
2954:
2886:
2859:
2832:
2694:
2375:(MMP7), by interacting with the structural zinc atom and/or calcium atoms within the structural metal center of the protein.
1847:(photosensitivity not specified) when compared with other antimalarials. The rash resolves upon discontinuation of the drug.
877:
6403:
Leung E, Landa G (September 2013). "Update on current and future novel therapies for dry age-related macular degeneration".
2668:
2407:
exact mechanisms have yet to be fully discovered. One probable mechanism is doxycycline's ability to decrease the amount of
1752:
The combination of doxycycline with dairy, antacids, calcium supplements, iron products, laxatives containing magnesium, or
8649:
6540:
Henehan M, Montuno M, De Benedetto A (November 2017). "Doxycycline as an anti-inflammatory agent: updates in dermatology".
4434:
2590:. Doxycycline is more stable than tetracycline for this purpose. At subantimicrobial doses, doxycycline is an inhibitor of
6446:
Greenwald RA (December 2011). "The road forward: the scientific basis for tetracycline treatment of arthritic disorders".
6255:
6702:"Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice"
5554:"Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis"
4009:
430:)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
11041:
11036:
8086:"Association between depression and antibiotic use: analysis of population-based National Health Insurance claims data"
7101:
Kontochristopoulos G, Tsiogka A, Agiasofitou E, Kapsiocha A, Soulaidopoulos S, Liakou AI, et al. (November 2022).
6157:
1891:
782:
183:
5284:
Mylonas I (January 2011). "Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration".
4288:
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L, et al. (Cochrane Skin Group) (April 2015).
2534:
is through wound dressings, which have evolved from mono- to three-layered systems to maximize healing effectiveness.
11046:
10598:
6813:"Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells"
6036:
5215:
751:
105:
2245:
As its patent grew near to expiring in the early 1970s, the patent became the subject of lawsuit between Pfizer and
11031:
10972:
10251:
9788:
9763:
7039:
Parish LC, Parish JL, Routh HB, Witkowski JA (2005). "The treatment of acne vulgaris with low dosage doxycycline".
5931:
2465:, and anti-inflammatory mechanisms. In this context, it is important to note that doxycycline is able to cross the
1660:
8463:"Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research"
7796:"Tetracyclines Diminish In Vitro IFN-γ and IL-17-Producing Adaptive and Innate Immune Cells in Multiple Sclerosis"
3884:"Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group"
3495:"Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite"
2348:(NF-κB) pathway, which is responsible for upregulating several inflammatory mediators in various cells, including
1473:
Subantimicrobial-dose doxycycline (SDD) is widely used as an adjunctive treatment to scaling and root planing for
11021:
1834:
1830:
398:
278:
164:
6143:
4203:
Garner SE, Eady A, Bennett C, Newton JN, Thomas K, Popescu CM, et al. (Cochrane Skin Group) (August 2012).
4071:
3833:"Doxycycline vs azithromycin in patients with scrub typhus: a systematic review of literature and meta-analysis"
10827:
8180:
6209:
6187:
2255:
6618:
Lagente V, Victoni T, Boichot E (2011). "Matrix Metalloproteinase Inhibitors as New Anti-inflammatory Drugs".
6118:
10391:
5725:
Archer JS, Archer DF (June 2002). "Oral contraceptive efficacy and antibiotic interaction: a myth debunked".
5503:"Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection"
3814:
3723:
5241:
Chung AM, Reed MD, Blumer JL (2002). "Antibiotics and breast-feeding: a critical review of the literature".
1756:
is not inherently dangerous, but any of these foods and supplements may decrease absorption of doxycycline.
11026:
9849:
2278:
Doxycycline is available worldwide under many brand names. Doxycycline is available as a generic medicine.
1793:
1274:
1048:
1038:
643:
524:
7602:"Unveiling the Osteogenic Potential of Tetracyclines: A Comparative Study in Human Mesenchymal Stem Cells"
6343:
5466:
Affolter K, Samowitz W, Boynton K, Kelly ED (August 2017). "Doxycycline-induced gastrointestinal injury".
8963:
2329:
929:
604:
9451:
9355:
9006:
5219:
10991:
8711:
6583:
Berman B, Perez OA, Zell D (January 2007). "Update on rosacea and anti-inflammatory-dose doxycycline".
1858:
1854:
593:
9780:
7894:
de Witte LD, Munk Laursen T, Corcoran CM, Kahn RS, Birnbaum R, Munk-Olsen T, et al. (July 2023).
5199:(in German). Vienna: Österreichischer Apothekerverlag. Doxycyclin Genericon 200 mg lösliche Tabletten.
10671:
9695:
6028:
5966:(in German). Vol. 4 (24 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. Doxycyclin.
2914:
2595:
2502:
2498:
2482:
1861:, patients who were prescribed doxycycline for their acne had a 2.25-fold greater risk of developing
1797:
1781:
1738:
1734:
1585:
1111:
953:
884:. In 2022, it was the 68th most commonly prescribed medication in the United States, with more than 9
796:
8512:"Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research"
6955:
Eichenfield DZ, Sprague J, Eichenfield LF (November 2021). "Management of Acne Vulgaris: A Review".
5774:
1925:
be made. This stops bacterial growth giving the immune system time to kill and remove the bacteria.
1850:
Unlike some other members of the tetracycline group, it may be used in those with renal impairment.
9214:
8763:
6021:"Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals"
4720:
4628:
4508:
2547:
2424:
2360:
2333:
2017:
1981:
1821:
1692:
1629:. Field trials in 2005 showed an eight-week course of doxycycline almost eliminates the release of
1341:
1322:
1093:
1085:
913:
803:
620:
8958:
6158:"Nationwide Shortage of Doxycycline: Resources for Providers and Recommendations for Patient Care"
4337:
Cao H, Yang G, Wang Y, Liu JP, Smith CA, Luo H, et al. (Cochrane Skin Group) (January 2015).
10960:
10822:
10799:
10566:
10239:
9751:
8748:
7745:
Santos M, Gonçalves-Santos E, Gonçalves R, Santos E, Campos C, Bastos D, et al. (May 2021).
2466:
2412:
2408:
2246:
2225:
1287:
220:
122:
7432:
Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, et al. (May 2016).
5605:
5149:"Emerging therapies in transthyretin amyloidosis – a new wave of hope after years of stagnancy?"
4834:"Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum"
4085:
Taylor-Salmon E, Shapiro ED (April 2024). "Tick-borne infections in children in North America".
2367:(ECM) and thus are suggested to be important in the process of several diseases associated with
1900:. It works by preventing bacteria from reproducing through the inhibition of protein synthesis.
1824:
antibiotic group. Doxycycline can cause gastrointestinal upset. Oral doxycycline can cause pill
10810:
10686:
10642:
10358:
10298:
10195:
9977:
9097:
7992:
Paldino E, Balducci C, La Vitola P, Artioli L, D'Angelo V, Giampà C, et al. (April 2020).
7794:
Florou DT, Mavropoulos A, Dardiotis E, Tsimourtou V, Siokas V, Aloizou AM, et al. (2021).
7228:"Doxycycline, an Antibiotic or an Anti-Inflammatory Agent? The Most Common Uses in Dermatology"
5769:
4719:
Hashemi SH, Gachkar L, Keramat F, Mamani M, Hajilooi M, Janbakhsh A, et al. (April 2012).
3444:
Luger SW, Paparone P, Wormser GP, Nadelman RB, Grunwaldt E, Gomez G, et al. (March 1995).
3345:
3331:
2594:, and has been used in various experimental systems for this purpose, such as for recalcitrant
2591:
2486:
2345:
2043:
1874:
1718:
1426:
1419:
1332:
1317:
1311:
1306:
1279:
1239:
1223:
1116:
1015:
347:
8219:
Butler CC, Yu LM, Dorward J, Gbinigie O, Hayward G, Saville BR, et al. (September 2021).
4629:"Guidelines for the Use of Doxycycline Post-Exposure Prophylaxis for Bacterial STI Prevention"
3882:
Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, et al. (March 2013).
2876:
2849:
2822:
2307:
573:
513:
10816:
10134:
9985:
9981:
5078:
2944:
2267:
2079:
1753:
1680:
1626:
1590:
1546:
1506:
1354:
1098:
1078:
997:
979:
5604:
Dréno B, Bettoli V, Ochsendorf F, Layton A, Mobacken H, Degreef H (November–December 2004).
3917:
Biggs HM, Behravesh CB, Bradley KK, Dahlgren FS, Drexler NA, Dumler JS, et al. (2016).
3493:
Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, et al. (July 2001).
10736:
10165:
9895:
9404:
8743:
8571:
8268:
Sharma S, Bhatt P, Asdaq S, Alshammari M, Alanazi A, Alrasheedi N, et al. (May 2022).
6713:
5359:"The end of a dogma: the safety of doxycycline use in young children for malaria treatment"
2785:
2730:
2634:
2443:
2403:
2364:
2359:
A potential explanation of doxycycline's anti-inflammatory properties is its inhibition of
2296:
2290:
2286:
Research areas on the application of doxycycline include the following medical conditions:
1985:
1921:
1897:
1486:
1444:
1128:
991:
533:
367:
142:
1381:
8:
10937:
10303:
10035:
10016:
9966:
9921:
9033:
8461:
Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, et al. (March 2015).
6764:"Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory"
3883:
3061:
Gjønnaess H, Holten E (1978). "Doxycycline (Vibramycin) in pelvic inflammatory disease".
2490:
2457:
Doxycycline is also studied for its neuroprotective properties which are associated with
2451:
2439:
1958:
1809:
1714:
1326:
1198:
1169:
1140:
985:
847:
823:
448:
439:
231:
227:
8575:
7994:"Neuroprotective Effects of Doxycycline in the R6/2 Mouse Model of Huntington's Disease"
7920:
7895:
7628:
7601:
7352:
7325:
7301:
7276:
6717:
6700:
Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, et al. (September 2016).
4564:
4539:
4484:
4457:
3859:
3832:
2789:
2734:
647:
624:
473:
10909:
10716:
10498:
10401:
9958:
9840:
8536:
8511:
8487:
8462:
8394:
8367:
8343:
8318:
8294:
8269:
8245:
8220:
8161:
8112:
8085:
8066:
8018:
7993:
7974:
7871:
7846:
7822:
7795:
7776:
7722:
7695:
7676:
7577:
7552:
7498:
7414:
7365:
7326:"From Breakouts to Bargains: Strategies for Patient-Centered, Cost-effective Acne Care"
7257:
7127:
7102:
7016:
6999:
6980:
6932:
6897:
6878:
6788:
6763:
6734:
6701:
6682:
6565:
6510:
6428:
6381:
6275:
5859:
5834:
5707:
5664:
5578:
5553:
5529:
5502:
5385:
5358:
5309:
5266:
5053:
5009:
4936:
4909:
4858:
4833:
4363:
4338:
4314:
4289:
4229:
4204:
4185:
4138:
3629:
3559:
3426:
3276:
Lee JJ, Chien AL (April 2024). "Rosacea in Older Adults and Pharmacologic Treatments".
3183:
3140:
3086:
2754:
1862:
1668:
1407:
1395:
1373:
1009:
194:
8618:
8236:
7896:"A Sex-Dependent Association Between Doxycycline Use and Development of Schizophrenia"
7529:
6829:
6812:
6498:
5783:
5328:"Bioterrorism and Drug Preparedness - Doxycycline Use by Pregnant and Lactating Women"
5041:
3918:
3470:
3445:
3039:
1904:
half-life, and it is also prevented from accumulating in the kidneys of patients with
10447:
10383:
10002:
9675:
9671:
9240:
8843:
8788:
8753:
8622:
8587:
8541:
8492:
8443:
8399:
8348:
8299:
8250:
8165:
8153:
8117:
8070:
8058:
8023:
7966:
7925:
7876:
7827:
7780:
7768:
7727:
7680:
7668:
7633:
7582:
7533:
7490:
7455:
7406:
7369:
7357:
7306:
7261:
7249:
7208:
7204:
7173:
7132:
7083:
7048:
7021:
6984:
6972:
6937:
6917:
6870:
6834:
6793:
6739:
6686:
6674:
6631:
6600:
6557:
6514:
6502:
6463:
6420:
6194:
6072:
6050:
6042:
6032:
5967:
5905:
5884:"Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines"
5864:
5810:
5787:
5742:
5699:
5656:
5620:
5583:
5534:
5483:
5448:
5416:
5390:
5301:
5258:
5254:
5170:
5129:
5119:
5045:
5001:
4963:
4941:
4863:
4742:
4690:"Sexually transmitted infections in San Francisco have fallen since doxyPEP roll-out"
4658:
4610:
4569:
4489:
4409:
4368:
4319:
4270:
4234:
4177:
4142:
4106:
4049:
3975:
3940:
3895:
3864:
3633:
3621:
3586:
3551:
3516:
3475:
3418:
3293:
3253:
3218:
3175:
3123:
Holmes NE, Charles PG (5 January 2009). "Safety and Efficacy Review of Doxycycline".
3078:
3043:
2950:
2882:
2855:
2828:
2803:
2746:
2742:
2578:
activated by doxycycline) and "tet-off" (gene expression inactivated by doxycycline)
2368:
2353:
2221:
2217:
2085:
2037:
1096:, and uncomplicated urethral, endocervical, or rectal infections in adults caused by
866:
319:
306:
156:
8641:
8334:
7978:
7502:
7418:
6882:
6569:
6432:
5711:
5313:
5079:"Doxycycline hyclate Susceptibility and Minimum Inhibitory Concentration (MIC) Data"
5057:
5013:
4189:
3998:
3563:
3430:
3187:
3144:
3090:
2758:
876:
Doxycycline was patented in 1957 and came into commercial use in 1967. It is on the
10505:
10484:
9723:
9667:
9295:
8833:
8768:
8716:
8614:
8579:
8531:
8523:
8482:
8474:
8433:
8389:
8379:
8338:
8330:
8289:
8281:
8240:
8232:
8189:
8145:
8107:
8097:
8050:
8013:
8005:
7956:
7915:
7907:
7866:
7858:
7817:
7807:
7758:
7717:
7707:
7660:
7623:
7613:
7572:
7564:
7525:
7516:
Ahuja TS (August 2003). "Doxycycline decreases proteinuria in glomerulonephritis".
7482:
7445:
7396:
7347:
7337:
7296:
7288:
7239:
7200:
7165:
7122:
7114:
7075:
7011:
6964:
6927:
6909:
6862:
6824:
6783:
6775:
6729:
6721:
6664:
6623:
6592:
6549:
6494:
6455:
6412:
6172:
5895:
5854:
5846:
5779:
5734:
5691:
5668:
5648:
5573:
5565:
5524:
5514:
5475:
5439:
Riond JL, Riviere JE (October 1988). "Pharmacology and toxicology of doxycycline".
5380:
5370:
5293:
5270:
5250:
5160:
5037:
4993:
4931:
4921:
4890:
4853:
4845:
4732:
4600:
4559:
4551:
4479:
4469:
4401:
4358:
4354:
4350:
4309:
4305:
4301:
4262:
4224:
4220:
4216:
4169:
4134:
4102:
4094:
4041:
3930:
3854:
3844:
3613:
3543:
3506:
3465:
3457:
3410:
3285:
3245:
3210:
3167:
3132:
3070:
3035:
3000:
2922:
2793:
2738:
2690:
2416:
2001:
1808:
recommends the use of doxycycline for treatment of Q fever and also for tick-borne
1621:, making the nematodes sterile, and thus reducing transmission of diseases such as
1231:
881:
660:
329:
261:
251:
57:
8983:
8527:
7862:
6596:
6482:
6111:"Pfizer, Inc. v. International Rectifier Corp., 545 F. Supp. 486 (C.D. Cal. 1980)"
5479:
2970:
2024:
are yellow, crystalline powders with a bitter taste. The latter smells faintly of
1873:
Previously, doxycycline was believed to impair the effectiveness of many types of
11005:
10873:
10119:
10063:
9714:
9709:
9421:
9290:
9285:
8706:
8510:
Chatzispyrou IA, Held NM, Mouchiroud L, Auwerx J, Houtkooper RH (November 2015).
8478:
7763:
7746:
7292:
6913:
6416:
4098:
2660:
2575:
2229:
1945:
binding rate of about 80–90%. Doxycycline penetrates into almost all tissues and
1934:
1878:
1149:
1123:
1021:
357:
337:
8979:
8975:
8971:
8967:
6779:
6627:
4430:
3511:
3494:
3414:
1044:
Specifically, doxycycline is indicated for treatment of the following diseases:
10966:
10625:
10476:
10307:
10245:
10173:
10142:
10071:
10039:
9970:
9929:
9906:
9871:
9757:
9574:
9504:
9489:
9250:
9135:
9123:
9001:
8858:
8853:
8738:
8672:
8438:
8421:
8319:"Multi-drug Treatment for COVID-19-induced Acute Respiratory Distress Syndrome"
8285:
8193:
8102:
8054:
8009:
7961:
7944:
7568:
7450:
7433:
6459:
5569:
5519:
4832:
Dahl EL, Shock JL, Shenai BR, Gut J, DeRisi JL, Rosenthal PJ (September 2006).
4737:
4474:
3849:
3617:
3289:
3249:
2517:
2494:
2435:
2420:
2399:
2341:
2213:
1942:
1905:
1622:
1064:
1026:
10465:
8149:
7812:
7486:
7191:
Bikowski JB (2003). "Subantimicrobial dose doxycycline for acne and rosacea".
7169:
6009:(in German). Vienna: Österreichischer Apothekerverlag. Minostad 50 mg-Kapseln.
5375:
5297:
4997:
4926:
3214:
3171:
3074:
2798:
2773:
2683:
2411:(ROS). Inflammation in rosacea may be associated with increased production of
11015:
10941:
10606:
10409:
10299:
10177:
10150:
10085:
10075:
9831:
9811:
9719:
9663:
9655:
9617:
9607:
9579:
9559:
9549:
9544:
9509:
9494:
9431:
9426:
9350:
9315:
9103:
8877:
8867:
8798:
7911:
7600:
Martin V, Bettencourt AF, Santos C, Fernandes MH, Gomes PS (September 2023).
7401:
7384:
7244:
7227:
7100:
7079:
6762:
Wehrli JM, Xia Y, Offenhammer B, Kleim B, Müller D, Bach DR (February 2023).
6669:
6652:
6165:
6046:
5991:
5133:
4540:"Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women"
4005:
3979:
2508:
After a large-scale trial showed no benefit of using doxycycline in treating
2325:
2321:
2234:
2186:
1989:
1954:
1769:
1710:
1647:
1630:
1478:
1474:
1439:
1431:
1259:
1192:
933:
896:
819:
636:
8583:
7275:
Zolotarev O, Khakimova A, Rahim F, Senel E, Zatsman I, Gu D (October 2023).
6968:
5760:
DeRossi SS, Hersh EV (October 2002). "Antibiotics and oral contraceptives".
5738:
4266:
3533:
1953:, liver, kidneys, lung, breast milk, bone and genitals; low ones in saliva,
22:
10927:
10913:
10762:
10742:
10575:
10561:
10438:
10414:
10372:
10348:
10311:
10201:
10191:
10111:
10101:
9933:
9910:
9861:
9822:
9703:
9699:
9627:
9564:
9534:
9499:
9469:
9305:
9280:
9265:
9255:
9245:
9219:
9160:
9108:
9055:
9028:
9018:
8838:
8823:
8758:
8676:
8626:
8545:
8496:
8447:
8403:
8352:
8303:
8254:
8157:
8121:
8062:
8027:
7970:
7929:
7880:
7831:
7772:
7731:
7712:
7672:
7637:
7586:
7537:
7494:
7459:
7361:
7310:
7253:
7212:
7177:
7136:
7087:
7052:
7025:
6976:
6941:
6874:
6866:
6838:
6797:
6743:
6678:
6604:
6561:
6506:
6467:
6424:
5909:
5868:
5791:
5746:
5703:
5660:
5624:
5587:
5538:
5487:
5394:
5305:
5262:
5174:
5049:
5005:
4945:
4881:
Holmes NE, Charles PG (2009). "Safety and Efficacy Review of Doxycycline".
4867:
4746:
4614:
4573:
4493:
4413:
4372:
4323:
4274:
4238:
4181:
4146:
4110:
4053:
3944:
3935:
3899:
3868:
3625:
3520:
3297:
3257:
3179:
2919:
World Health Organization model list of essential medicines: 21st list 2019
2807:
2750:
2587:
2567:
2470:
2238:
2154:
1938:
1843:
1773:
1529:
1512:
Appropriate use of doxycycline for PEP is supported by guidelines from the
1210:
1186:
1056:
1034:
1030:
917:
827:
256:
246:
8591:
7618:
7410:
7154:
5501:
Hung YP, Lee JC, Lin HJ, Liu HC, Wu YH, Tsai PJ, et al. (June 2015).
5452:
4651:
4555:
4173:
3590:
3555:
3547:
3479:
3422:
3222:
3047:
2693:. Centers for Disease Control and Prevention. February 2023. Doxycycline.
948:
In Canada, in 2004, doxycycline was considered a first-line treatment for
10881:
10791:
10767:
10752:
10701:
10650:
10611:
10519:
10493:
10488:
10419:
10342:
10331:
10215:
10182:
10146:
10089:
10006:
9996:
9992:
9889:
9885:
9875:
9689:
9635:
9612:
9539:
9524:
9519:
9436:
9323:
9300:
9275:
9270:
9260:
9079:
9050:
8913:
8908:
8903:
8828:
8808:
8793:
8688:
8384:
7945:"The Neuroprotective Effect of Doxycycline on Neurodegenerative Diseases"
7693:
7225:
5900:
5883:
5850:
5695:
4849:
4045:
3461:
3313:"Doxycycline:" New" treatment of choice for genital chlamydia infections"
3082:
2949:(12th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 79.
2458:
2363:(MMPs), which are a group of proteases known to regulate the turnover of
2300:
1966:
1950:
1825:
1525:
1499:
1453:
1414:
1176:
1105:
1003:
941:
921:
904:
851:
150:
7342:
6224:"FDA reports shortage of doxycycline antibiotic. What are your options?"
5923:
4405:
4287:
2926:
2721:
Nelson ML, Levy SB (December 2011). "The history of the tetracyclines".
2371:
and inflammation. Doxycycline has been shown to inhibit MMPs, including
493:
30:
10804:
10732:
10711:
10696:
10589:
10535:
10509:
10424:
10154:
10123:
10107:
10079:
9943:
9939:
9810:
9685:
9645:
9640:
9589:
9569:
9554:
9529:
9484:
9479:
9413:
9384:
9364:
9184:
9179:
9170:
9165:
9150:
9145:
9093:
9045:
8959:
8917:
8803:
8783:
8730:
7942:
7277:"Scientometric analysis of trends in global research on acne treatment"
7226:
Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R (September 2020).
6651:
Wang S, Liu C, Liu X, He Y, Shen D, Luo Q, et al. (October 2017).
5998:
4605:
4588:
2521:
2209:
2170:
2092:
1973:
1946:
1933:
The substance is almost completely absorbed from the upper part of the
1812:
diseases in young children and others advocate for its use in malaria.
1801:
1722:
1655:
1651:
1562:
1533:
1382:
Specific applications of doxycycline when penicillin is contraindicated
1292:
1203:
1069:
870:
799:
693:
504:
7664:
7650:
7118:
6725:
6553:
5652:
5203:
5165:
5148:
4894:
4067:
3603:
3136:
2501:. While there is some research on the use of doxycycline for treating
1482:
tapering or treatment with a lower dose over a longer period of time.
1386:
When penicillin is contraindicated, doxycycline can be used to treat:
39:
10757:
10706:
10655:
10630:
10619:
10545:
10514:
10320:
10054:
9867:
9857:
9514:
9474:
9461:
9394:
9389:
9379:
9374:
9369:
9200:
9155:
9118:
9113:
9084:
9074:
9064:
8893:
8813:
8726:
8696:
7744:
2583:
2462:
1980:. About 40% are eliminated via the kidneys, much less in people with
1780:
are contraindications, as both tetracyclines and retinoids can cause
1643:
1618:
1612:
1607:
1603:
1566:
1493:
1156:
1135:
1019:, have shown resistance to doxycycline. It is also effective against
961:
949:
925:
815:
811:
459:
380:
136:
7943:
Santa-Cecília FV, Leite CA, Del-Bel E, Raisman-Vozari R (May 2019).
7793:
6013:
5413:
Top 100 drugs : clinical pharmacology and practical prescribing
2228:
of antibiotics. Shortly thereafter, scientists at Pfizer discovered
1663:
susceptibility data for a few medically significant microorganisms.
10211:
10012:
9818:
9815:
9599:
9069:
9040:
8872:
8818:
8040:
7844:
6811:
Liu J, Xiong W, Baca-Regen L, Nagase H, Baxter BT (December 2003).
2571:
2509:
2337:
2303:(both of which have demonstrated modest efficacy for this disease).
2082:
2005:
1962:
1777:
1615:
1390:
1251:
1181:
1089:
957:
858:
839:
807:
553:
484:
178:
5833:
Maaland MG, Papich MG, Turnidge J, Guardabassi L (November 2013).
5606:"European recommendations on the use of oral antibiotics for acne"
4803:"Malaria - Chapter 3 - 2018 Yellow Book | Travelers' Health | CDC"
3972:"Use doxycycline as first-line treatment for rickettsial diseases"
3831:
Gupta N, Boodman C, Jouego CG, Van Den Broucke S (December 2023).
2220:
was one of these, and in the late 1940s chemists there discovered
1581:
but creates conditions that prevent their growth and replication.
716:
10899:
10540:
9899:
9584:
8898:
8778:
8701:
7694:
Orylska-Ratynska M, Placek W, Owczarczyk-Saczonek A (June 2022).
6622:. Progress in Inflammation Research. Springer. pp. 101–122.
6250:
4390:
3830:
3339:"Doxycycline spectrum of bacterial susceptibility and Resistance"
2551:
2478:
2395:
2387:
2263:
2029:
2025:
2021:
1977:
1555:
1368:
1162:
1060:
937:
862:
843:
831:
739:
CN(C)3C(\O)=C(\C(N)=O)C(=O)4(O)C(/O)=C2/C(=O)c1c(cccc1O)(C)2(O)34
8509:
7893:
7696:"Tetracyclines-An Important Therapeutic Tool for Dermatologists"
7599:
6097:
Goodman & Gilman's The Pharmacological Basis of Therapeutics
5832:
4621:
1749:
Doxycycline can be administered via oral or intravenous routes.
9681:
8685:
8365:
7991:
5356:
3157:
3001:"Doxycycline Drug Usage Statistics, United States, 2013 - 2022"
2349:
1052:
835:
584:
10789:
7845:
Garrido-Mesa J, Adams K, Galvez J, Garrido-Mesa N (May 2022).
7431:
6542:
Journal of the European Academy of Dermatology and Venereology
4952:
4455:
4251:
3024:
1466:
Doxycycline may also be used as adjunctive therapy for severe
1300:
1217:
912:
In addition to the general indications for all members of the
93:
6954:
6150:
5410:
4159:
3916:
3881:
2447:
2352:; therefore, it is studied as a potential agent for treating
2259:
1909:
1820:
Adverse effects are similar to those of other members of the
861:, nausea, vomiting, abdominal pain, and an increased risk of
707:
564:
8561:
7274:
6344:"Doxycycline Hyclate Prices and Doxycycline Hyclate Coupons"
5681:
5603:
5465:
5357:
Gaillard T, Briolant S, Madamet M, Pradines B (April 2017).
4060:
3443:
3400:
3200:
2574:
experimental results. Doxycycline is also used in "tet-on" (
2336:(MMPs) while increasing the production of anti-inflammatory
609:
8604:
6904:. Progress in Molecular Biology and Translational Science.
5805:
Flower R, Rang HP, Dale MM, Ritter JM, Henderson G (2012).
4718:
4030:
3492:
3378:. Atlanta, GA: Centers for Disease Control and Prevention.
2474:
2434:, such as rosacea and acne, but also in conditions such as
2431:
2391:
2383:
2372:
1969:
penetrates significantly better into the CSF and meninges.
1853:
Doxycycline use has been associated with increased risk of
1467:
1402:
544:
84:
8419:
8267:
7550:
7038:
6539:
6216:
5026:
4123:
66:
9341:
8992:
6851:
6761:
2913:
1544:
Doxycycline is active against the erythrocytic stages of
75:
8460:
7473:
Wise RD (2007). "Submicrobial doxycycline and rosacea".
7434:"Guidelines of care for the management of acne vulgaris"
7382:
6810:
6310:
4982:
4962:. Geneva: World Health Organization. 2015. p. 246.
4456:
Vanbaelen T, Manoharan-Basil SS, Kenyon C (April 2024).
4006:"Spotted fever group rickettsial disease | DermNet"
2929:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
2237:
modified these compounds, which led to the invention of
1733:
Doxycycline has found off-label use in the treatment of
1532:
and the second-line is a combination of doxycycline and
8420:
Saliy O, Popova M, Tarasenko H, Getalo O (April 2024).
8218:
7383:
Akamatsu H, Asada M, Komura J, Asada Y, Niwa Y (1992).
4907:
4202:
2814:
2469:. Several studies have shown that doxycycline inhibits
2033:
1485:
Doxycycline is used as an adjunctive therapy for acute
1309:
have developed resistance to doxycycline. Up to 44% of
878:
World Health Organization's List of Essential Medicines
8366:
Dorobisz K, Dorobisz T, Janczak D, Zatoński T (2021).
8134:
7551:
Patel A, Khande H, Periasamy H, Mokale S (June 2020).
6271:"Officials Question the Rising Costs of Generic Drugs"
6246:"Sudden increase in cost of common drug concerns many"
5961:
5957:
5955:
5953:
5951:
5949:
5552:
Tan KR, Magill AJ, Parise ME, Arguin PM (April 2011).
4586:
3798:
3796:
3794:
3792:
3790:
3788:
3786:
3784:
3782:
3780:
3778:
3776:
3774:
3772:
3770:
3768:
3766:
3764:
3762:
3760:
3758:
3756:
3707:
3705:
3703:
3701:
3699:
3697:
3695:
3693:
3691:
3689:
3687:
3685:
3683:
3681:
3679:
3677:
3675:
3673:
3671:
3669:
3667:
3665:
3663:
3369:
1594:
or following intravenous treatment of severe malaria.
1500:
As prophylaxis against sexually transmitted infections
1492:
Doxycycline is also used as an adjunctive therapy for
10989:
8671:
8368:"Doxycycline in the Coronavirus Disease 2019 Therapy"
7000:"Oral Antibiotic Treatment Options for Acne Vulgaris"
6617:
5558:
The American Journal of Tropical Medicine and Hygiene
5551:
5146:
3754:
3752:
3750:
3748:
3746:
3744:
3742:
3740:
3738:
3736:
3661:
3659:
3657:
3655:
3653:
3651:
3649:
3647:
3645:
3643:
2881:. Hoboken, N.J.: John Wiley & Sons. p. 406.
2878:
Drug discovery practices, processes, and perspectives
2637:. The American Society of Health-System Pharmacists.
2570:
impairing metabolism and leading to effects that can
2046:
1896:
Doxycycline, like other tetracycline antibiotics, is
1784:(increased pressure around the brain) in rare cases.
1516:(CDC) and the Australasian Society for HIV Medicine.
106:
96:
87:
81:
72:
69:
60:
6483:"Minocycline and Doxycycline: More Than Antibiotics"
5804:
5637:
5411:
Hitchings A, Lonsdale D, Burrage D, Baker E (2015).
4773:"Doryx- doxycycline hyclate tablet, delayed release"
4205:"Minocycline for acne vulgaris: efficacy and safety"
4084:
3577:
Weinstein RS (November 1996). "Human ehrlichiosis".
3370:
Stoddard RA, Galloway RL, Guerra MA (10 July 2015).
1577:. It does not directly kill the living organisms of
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63:
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6142:. The Associated Press. 6 July 1983. Archived from
6094:
6071:(6th ed.). Lippincott Williams & Wilkins.
5946:
4908:Gaillard T, Madamet M, Pradines B (November 2015).
3969:
3235:
2820:
1892:
Tetracycline antibiotics § Mechanism of action
78:
8181:"Platform trial rules out treatments for COVID-19"
8179:
6296:"Hikma hits the jackpot with doxycycline shortage"
5147:Müller M, Butler J, Heidecker B (7 January 2020).
4831:
4431:"Doxycycline Dosage Guide + Max Dose, Adjustments"
3733:
3640:
2580:tetracycline-controlled transcriptional activation
2564:tetracycline-controlled transcriptional activation
2070:
6699:
6066:
5406:
5404:
4587:Cornelisse VJ, Riley B, Medland NA (April 2024).
2514:National Institute for Health and Care Excellence
11013:
8415:
8413:
7150:
7148:
7146:
6757:
6755:
6753:
6480:
6130:
6128:
2938:
2936:
472:
8557:
8555:
7323:
7066:Stein Gold LF (June 2016). "Acne: What's New".
6582:
5916:
5828:
5826:
5599:
5597:
5240:
4681:
4386:
4384:
4382:
3271:
3269:
3267:
3060:
2847:
916:group, doxycycline is frequently used to treat
447:
6262:
5727:Journal of the American Academy of Dermatology
5434:
5432:
5401:
4336:
3970:Schutze GE, Regan J, Bradley J (1 July 2010).
3118:
3116:
3114:
3112:
3110:
3108:
3106:
3104:
3102:
3100:
2716:
2714:
2712:
2473:neurodegeneration through the upregulation of
806:used in the treatment of infections caused by
11052:World Health Organization essential medicines
10284:
9796:
8944:
8657:
8598:
8503:
8454:
8410:
8359:
8310:
8261:
8212:
8128:
8077:
8034:
7985:
7936:
7887:
7838:
7787:
7738:
7687:
7644:
7593:
7544:
7509:
7466:
7425:
7317:
7268:
7219:
7184:
7143:
7094:
7059:
7032:
6991:
6948:
6889:
6845:
6804:
6750:
6693:
6644:
6620:Proteases and Their Receptors in Inflammation
6611:
6576:
6533:
6474:
6439:
6396:
6206:American Society of Health-System Pharmacists
6184:American Society of Health-System Pharmacists
6125:
6095:Brunton LL, Chabner BA, Knollmann BC (eds.).
6090:
6088:
6062:
6060:
5881:
5500:
5209:
5073:
5071:
5069:
5067:
4880:
4765:
3363:
3122:
3063:Acta Obstetricia et Gynecologica Scandinavica
3028:American Journal of Obstetrics and Gynecology
2933:
2653:
1965:. By comparison, the tetracycline antibiotic
1636:
1514:US Centers for Disease Control and Prevention
8552:
7376:
6650:
6374:"International availability for doxycycline"
6287:
6238:
5985:
5983:
5875:
5823:
5759:
5753:
5724:
5718:
5675:
5631:
5594:
5545:
5494:
5459:
5438:
5350:
5277:
5234:
5118:(2nd ed.). Philadelphia, PA: Saunders.
5107:
5020:
4976:
4901:
4825:
4725:International Journal of Infectious Diseases
4712:
4580:
4531:
4449:
4425:
4423:
4379:
4330:
4281:
4245:
4196:
4153:
4117:
4078:
4024:
3974:. AAP News. American Academy of Pediatrics.
3963:
3910:
3875:
3824:
3597:
3486:
3264:
3229:
3151:
2667:. Public Health Scotland. Chemoprophylaxis.
1949:. Very high concentrations are found in the
1713:in slow-flow vascular malformations, namely
1461:
182:
5798:
5429:
5415:. Churchill Livingstone. pp. 200–201.
5140:
4874:
4500:
4343:The Cochrane Database of Systematic Reviews
4339:"Complementary therapies for acne vulgaris"
4294:The Cochrane Database of Systematic Reviews
4209:The Cochrane Database of Systematic Reviews
3606:Scandinavian Journal of Infectious Diseases
3570:
3527:
3437:
3394:
3304:
3194:
3097:
3018:
2841:
2765:
2709:
1937:. It reaches highest concentrations in the
1744:
1321:specimens have developed resistance to the
1301:Gram-positive bacteria specific indications
1218:Gram-negative bacteria specific indications
10291:
10277:
9803:
9789:
9412:
8951:
8937:
8664:
8650:
8083:
7065:
6402:
6366:
6103:
6085:
6057:
5113:
5064:
4687:
3054:
2723:Annals of the New York Academy of Sciences
2720:
2629:
2627:
2625:
2623:
2621:
2619:
2617:
2615:
2613:
2611:
2550:of antibiotics are often used as research
2315:
1787:
1352:skin and soft tissue infections caused by
1029:), and is prescribed for the treatment of
646:
623:
512:
8535:
8486:
8437:
8393:
8383:
8342:
8293:
8244:
8111:
8101:
8017:
7960:
7919:
7870:
7821:
7811:
7762:
7721:
7711:
7627:
7617:
7576:
7449:
7400:
7351:
7341:
7300:
7243:
7126:
7015:
6931:
6895:
6828:
6787:
6733:
6668:
6445:
6268:
6004:
5980:
5899:
5888:The Journal of Antimicrobial Chemotherapy
5858:
5773:
5577:
5528:
5518:
5384:
5374:
5194:
5164:
4935:
4925:
4857:
4736:
4604:
4563:
4483:
4473:
4420:
4362:
4313:
4228:
3934:
3858:
3848:
3576:
3510:
3469:
2868:
2797:
1561:Doxycycline blocks protein production in
532:
7190:
6069:Foye's Principles of Medicinal Chemistry
5684:The American Journal of Gastroenterology
5320:
3275:
2942:
2771:
2306:
903:
900:Generic 100 mg doxycycline capsules
895:
8084:Lee JW, Lee H, Kang HY (October 2021).
6997:
6336:
6067:Williams DA, Foye WO, Lemke TL (2008).
5962:Dinnendahl, V, Fricke, U, eds. (2010).
5283:
4960:Guidelines for the treatment of malaria
4537:
2608:
2258:(which ceased production in May 2013),
1800:in pregnancy. Doxycycline crosses into
1659:, and others. The following represents
1611:bacteria in the reproductive tracts of
1339:upper respiratory infections caused by
1076:respiratory tract infections caused by
619:
492:
155:
11014:
7324:Shields A, Barbieri JS (August 2023).
6405:Expert Review of Clinical Pharmacology
6293:
4506:
3310:
2907:
2854:. John Wiley & Sons. p. 489.
2641:from the original on 23 September 2015
2273:
2078: −110° cm/dm·g in 0.01
2011:
1941:after one to two hours and has a high
1915:
972:
637:
300:
10272:
9784:
8932:
8645:
7515:
5990:
5934:from the original on 10 November 2008
5286:Archives of Gynecology and Obstetrics
5190:
5188:
5186:
5184:
5116:Vascular and interventional radiology
5095:from the original on 24 February 2015
4838:Antimicrobial Agents and Chemotherapy
4663:Australasian Society for HIV Medicine
3450:Antimicrobial Agents and Chemotherapy
3327:from the original on 2 February 2017.
2921:. Geneva: World Health Organization.
2874:
2697:from the original on 13 November 2016
2546:Doxycycline and other members of the
1908:due to the compensatory excretion in
1519:
592:
572:
313:
173:
141:
8043:Naunyn-Schmiedeberg's Arch Pharmacol
7472:
6521:from the original on 2 February 2024
5882:Agwuh KN, MacGowan A (August 2006).
5809:. Edinburgh: Churchill Livingstone.
5338:from the original on 8 February 2019
4813:from the original on 3 December 2018
4437:from the original on 5 February 2024
4012:from the original on 5 February 2024
3986:from the original on 5 February 2024
3951:from the original on 28 January 2023
3804:"Doxycycline, ANDA no. 065454 Label"
3713:"Doxycycline, ANDA no. 065055 Label"
3238:The Medical Clinics of North America
2895:from the original on 14 January 2023
2691:"Choosing a Drug to Prevent Malaria"
2671:from the original on 4 December 2023
1763:
1528:is a combination of doxycycline and
260:
250:
8316:
6481:Singh S, Khanna D, Kalra S (2021).
5114:Kaufman JA, Lee MJ (22 June 2013).
4986:Medical Microbiology and Immunology
4795:
4783:from the original on 3 January 2022
4753:from the original on 28 August 2021
4509:"Using antibiotics to prevent STIs"
3906:from the original on 19 April 2014.
3499:The New England Journal of Medicine
2981:from the original on 30 August 2024
2541:
1928:
1550:but not against the gametocytes of
552:
463:
13:
6208:. 12 November 2014. Archived from
6186:. 12 December 2014. Archived from
6180:"Doxycycline Capsules and Tablets"
5181:
4700:from the original on 10 March 2024
4669:from the original on 10 March 2024
4639:from the original on 10 March 2024
4519:from the original on 10 March 2024
4139:10.1016/j.diagmicrobio.2024.116215
4074:from the original on 10 June 2016.
3722:. 14 December 2012. Archived from
1961:(CSF), and especially in inflamed
1815:
1792:Doxycycline is categorized by the
14:
11063:
8637:
8607:American Journal of Ophthalmology
6499:10.2174/1874467214666210210122628
6354:from the original on 28 July 2016
6324:from the original on 4 March 2016
6230:. 4 February 2013. Archived from
5216:U.S. National Library of Medicine
5153:European Journal of Heart Failure
3923:MMWR. Recommendations and Reports
3888:MMWR. Recommendations and Reports
3811:U.S. Food and Drug Administration
3720:U.S. Food and Drug Administration
3382:from the original on 9 April 2017
1597:
287:
205:
10999:
8225:The Lancet. Respiratory Medicine
8200:from the original on 1 June 2022
7205:10.1111/j.1540-9740.2003.03014.x
5839:Journal of Clinical Microbiology
5255:10.2165/00128072-200204120-00006
3317:British Columbia Medical Journal
2743:10.1111/j.1749-6632.2011.06354.x
2528:
1920:Doxycycline is a broad-spectrum
1728:
1704:
1661:minimum inhibitory concentration
967:
908:A package of generic doxycycline
880:. Doxycycline is available as a
677:
671:
56:
38:
29:
8335:10.4274/tjps.galenos.2021.63060
7700:Int J Environ Res Public Health
6254:. 12 March 2013. Archived from
6202:"Doxycycline Hyclate Injection"
5762:Dental Clinics of North America
5613:European Journal of Dermatology
5441:Veterinary and Human Toxicology
4883:Clinical Medicine. Therapeutics
4544:New England Journal of Medicine
4162:European Journal of Dermatology
3125:Clinical Medicine. Therapeutics
2993:
2963:
2848:Fischer J, Ganellin CR (2006).
1885:
1868:
1539:
891:
764:Key:XQTWDDCIUJNLTR-CVHRZJFOSA-N
127:Doxy, Doryx, Vibramycin, others
10828:piperaquine/dihydroartemisinin
9452:transpeptidation/translocation
7232:Actas Dermosifiliogr (Engl Ed)
6269:Rosenthal E (7 October 2014).
6164:. 12 June 2013. Archived from
6136:"Pfizer to Get Rachelle Units"
5807:Rang & Dale's Pharmacology
4538:Stewart J (21 December 2023).
4355:10.1002/14651858.CD009436.pub2
4306:10.1002/14651858.CD003262.pub5
4221:10.1002/14651858.CD002086.pub2
3813:. 16 July 2008. Archived from
2821:Schlagenhauf-Lawlor P (2008).
2054:
2047:
683:
665:
1:
10392:trimethoprim/sulfamethoxazole
8619:10.1016/S0002-9394(01)00913-8
8528:10.1158/0008-5472.CAN-15-1626
8237:10.1016/S2213-2600(21)00310-6
7863:10.1080/13543784.2022.2054325
7530:10.1016/s0272-6386(03)00662-0
6830:10.1016/s0741-5214(03)01022-x
6597:10.1358/dot.2007.43.1.1025697
6025:Environmental health criteria
5784:10.1016/S0011-8532(02)00017-4
5480:10.1016/j.humpath.2017.02.011
5210:PubMed Health (1 July 2016).
5042:10.1016/S0140-6736(05)66591-9
4688:Highleyman L (5 March 2024).
3040:10.1016/S0002-9378(16)44537-0
2851:Analogue-based Drug Discovery
2601:
2382:Doxycycline is used to treat
2311:Tet-ON inducible shRNA system
1709:Doxycycline is also used for
1524:The first-line treatment for
1325:of antibiotics. Up to 57% of
1185:species (in conjunction with
842:. It is also used to prevent
16:Tetracycline-class antibiotic
10790:Fixed-dose (co-formulated)
8479:10.1016/j.celrep.2015.02.034
7764:10.1016/j.intimp.2021.107462
7293:10.1097/JW9.0000000000000082
6998:Baldwin H (September 2020).
6914:10.1016/bs.pmbts.2017.04.003
6417:10.1586/17512433.2013.829645
4099:10.1097/MOP.0000000000001326
4034:Clinical Infectious Diseases
2586:expression in organisms and
1995:
1721:, as well as post-operative
1275:respiratory tract infections
1067:, and tick fevers caused by
1055:fever and the typhus group,
1049:Rocky Mountain spotted fever
1039:Rocky Mountain spotted fever
857:Common side effects include
7:
6780:10.1523/ENEURO.0243-22.2023
6628:10.1007/978-3-0348-0157-7_5
4290:"Interventions for rosacea"
3512:10.1056/NEJM200107123450201
3415:10.7326/0003-4819-117-4-273
3403:Annals of Internal Medicine
3311:Rekart ML (December 2004).
2330:tumor necrosis factor-alpha
2281:
930:pelvic inflammatory disease
846:. Doxycycline may be taken
10:
11068:
8712:Sodium monofluorophosphate
8439:10.1016/j.ejps.2023.106636
8286:10.1016/j.jiph.2022.03.014
8194:10.3310/nihrevidence_50873
8103:10.1186/s12888-021-03550-2
8055:10.1007/s00210-023-02435-3
8010:10.1007/s12035-019-01847-8
7962:10.1007/s12640-019-00015-z
7851:Expert Opin Investig Drugs
7569:10.1007/s10753-020-01188-y
7451:10.1016/j.jaad.2015.12.037
6460:10.1016/j.phrs.2011.06.010
6294:Palmer E (13 March 2014).
5570:10.4269/ajtmh.2011.10-0285
5520:10.3390/antibiotics4020216
4910:"Tetracyclines in malaria"
4738:10.1016/j.ijid.2011.12.003
4475:10.1186/s12879-024-09275-3
4127:Diagn Microbiol Infect Dis
3850:10.1186/s12879-023-08893-7
3618:10.1080/003655401750064130
3290:10.1007/s40266-024-01115-y
3250:10.1016/j.mcna.2008.06.002
2772:McFadden GI (March 2014).
2596:recurrent corneal erosions
2483:neurodegenerative diseases
2224:, the first member of the
2203:
2008:due to catabolic effects.
1889:
1855:inflammatory bowel disease
1637:Spectrum of susceptibility
655:Chemical and physical data
11042:Drugs developed by Pfizer
11037:Drugs developed by AbbVie
10950:
10926:
10898:
10872:
10836:
10780:
10725:
10685:
10672:sulfadoxine/pyrimethamine
10664:
10641:
10597:
10588:
10554:
10528:
10475:
10464:
10455:
10446:
10437:
10400:
10382:
10357:
10341:
10330:
10319:
10229:
10164:
10133:
10062:
10053:
10026:
9957:
9920:
9848:
9839:
9830:
9741:
9696:Quinupristin/dalfopristin
9654:
9626:
9598:
9460:
9449:
9403:
9349:
9340:
9314:
9228:
9213:
9193:
9132:
9015:
9000:
8991:
8964:inhibit protein synthesis
8886:
8852:
8725:
8684:
8150:10.1016/j.bbr.2022.114187
7813:10.3389/fimmu.2021.739186
7487:10.1007/s12019-007-8003-x
7170:10.1016/j.jad.2021.05.083
7041:Acta Dermatovenerol Croat
6896:Liu J, Khalil RA (2017).
6318:"Costco Drug Information"
6300:FiercePharmaManufacturing
6029:World Health Organization
6005:Haberfeld H, ed. (2020).
5995:. Accessed 5 August 2020.
5641:Internal Medicine Journal
5376:10.1186/s12936-017-1797-9
5298:10.1007/s00404-010-1646-3
5195:Haberfeld H, ed. (2020).
4998:10.1007/s00430-002-0174-6
4927:10.1186/s12936-015-0980-0
4255:Journal of Periodontology
4068:"Lyme disease. Treatment"
3579:American Family Physician
3215:10.1001/archderm.133.1.49
3172:10.1007/s00417-005-0212-3
3075:10.3109/00016347809155893
2915:World Health Organization
2827:. PMPH-USA. p. 148.
2799:10.1016/j.cub.2014.01.024
2505:, the results are mixed.
2503:major depressive disorder
2361:matrix metalloproteinases
2334:matrix metalloproteinases
2071:{\displaystyle _{D}^{25}}
2016:Doxycycline, doxycycline
1782:intracranial hypertension
1739:tauroursodeoxycholic acid
1735:transthyretin amyloidosis
1586:World Health Organization
1462:Use as adjunctive therapy
1112:non-gonococcal urethritis
1025:(the infectious agent of
954:non-gonococcal urethritis
772:
747:
727:
705:
692:
659:
654:
635:
603:
583:
563:
543:
523:
503:
483:
458:
438:
394:
389:
379:
366:
356:
346:
336:
328:
277:
272:
237:
219:
193:
163:
149:
131:
121:
51:
46:
37:
28:
11047:Tetracycline antibiotics
9215:Tetracycline antibiotics
8764:Cetylpyridinium chloride
7402:10.2340/0001555572178179
7245:10.1016/j.ad.2019.12.006
7080:10.12788/j.sder.2016.036
6902:Prog Mol Biol Transl Sci
6670:10.1177/1010428317718192
6663:(10): 1010428317718192.
6448:Pharmacological Research
6162:CDC Health Alert Network
5212:"Doxycycline (By mouth)"
4507:Samuel K (26 May 2023).
1982:end-stage kidney disease
1745:Routes of administration
1693:Streptococcus pneumoniae
1554:. It is used to prevent
1342:Streptococcus pneumoniae
1288:urinary tract infections
1094:inclusion conjunctivitis
1086:Lymphogranuloma venereum
914:tetracycline antibiotics
11032:Dimethylamino compounds
10823:artesunate/pyronaridine
10800:artemether/lumefantrine
9978:Pentavalent antimonials
9850:African trypanosomiasis
8584:10.1126/science.7792603
8317:Ohe M (February 2022).
7004:J Clin Aesthet Dermatol
6969:10.1001/jama.2021.17633
5992:Professional Drug Facts
5739:10.1067/mjd.2002.120448
4267:10.1902/jop.2011.110026
3203:Archives of Dermatology
2592:matrix metalloproteases
2409:reactive oxygen species
2316:Anti-inflammatory agent
2247:International Rectifier
2105:Doxycycline monohydrate
1788:Pregnancy and lactation
1719:lymphatic malformations
888:million prescriptions.
385:Mainly feces, 40% urine
11022:Anti-acne preparations
10811:artesunate/amodiaquine
8274:J Infect Public Health
7912:10.1093/schbul/sbad008
7713:10.3390/ijerph19127246
6867:10.1124/mol.104.006346
3936:10.15585/mmwr.rr6502a1
2946:Tarascon pharmacopoeia
2346:nuclear factor-kappa B
2312:
2197:practically insoluble
2181:practically insoluble
2072:
1875:hormonal contraception
1772:or concomitant use of
1754:bile acid sequestrants
1737:(ATTR). Together with
1602:Doxycycline kills the
1420:Listeria monocytogenes
1360:methicillin-resistant
1347:Diplococcus pneumoniae
1333:Gram-positive bacteria
1312:Streptococcus pyogenes
1307:Gram-positive bacteria
1286:respiratory tract and
1280:Haemophilus influenzae
1240:Enterobacter aerogenes
1224:Gram-negative bacteria
1117:Ureaplasma urealyticum
1016:Pseudomonas aeruginosa
909:
901:
814:. It is used to treat
10845:artesunate/mefloquine
10817:artesunate/mefloquine
9986:Sodium stibogluconate
9982:Meglumine antimoniate
7619:10.3390/cells12182244
7281:Int J Womens Dermatol
7107:Skin Appendage Disord
6228:Consumer Reports News
4635:. 29 September 2023.
4556:10.1056/NEJMoa2304007
4174:10.1684/ejd.2014.2309
3548:10.1212/WNL.44.7.1203
2971:"The Top 300 of 2022"
2635:"Doxycycline calcium"
2425:antibiotic resistance
2310:
2268:Hikma Pharmaceuticals
2194:practically insoluble
2178:practically insoluble
2073:
1831:Clostridium difficile
1681:Mycoplasma pneumoniae
1547:Plasmodium falciparum
1507:Neisseria gonorrhoeae
1451:infections caused by
1362:Staphylococcus aureus
1355:Staphylococcus aureus
1099:Chlamydia trachomatis
1079:Mycoplasma pneumoniae
998:Mycoplasma pneumoniae
980:Moraxella catarrhalis
907:
899:
852:injection into a vein
10857:quinine/tetracycline
10529:4-Methanolquinolines
10304:antiprotozoal agents
9896:naphthalenesulfonate
9405:Peptidyl transferase
8899:Acetylsalicylic acid
8744:Benzoxonium chloride
8385:10.2147/TCRM.S314923
8372:Ther Clin Risk Manag
7068:Semin Cutan Med Surg
6283:on 23 February 2017.
6258:on 31 December 2014.
6168:on 15 February 2015.
6121:on 24 February 2015.
5851:10.1128/JCM.01498-13
5696:10.1038/ajg.2010.303
4850:10.1128/AAC.00394-06
4394:J Dtsch Dermatol Ges
4070:. 21 December 2018.
3462:10.1128/AAC.39.3.661
2943:Hamilton RJ (2011).
2444:rheumatoid arthritis
2365:extracellular matrix
2297:rheumatoid arthritis
2291:macular degeneration
2108:Doxycycline hyclate
2044:
1986:biological half-life
1487:intestinal amebiasis
1445:Actinomyces israelii
1271:species) infections,
1245:Aerobacter aerogenes
1129:Borrelia recurrentis
992:Chlamydia pneumoniae
824:chlamydia infections
11027:Antimalarial agents
10854:quinine/doxycycline
10851:quinine/clindamycin
10839:(not co-formulated)
9034:Dihydrostreptomycin
8576:1995Sci...268.1766G
7751:Int Immunopharmacol
7343:10.12788/cutis.0844
7074:(6 Suppl): S114–6.
6718:2016NatSR...632659J
5964:Arzneistoff-Profile
5334:. 3 November 2018.
5222:on 11 November 2013
5159:(1). Wiley: 39–53.
4779:. 23 October 2020.
4406:10.1111/ddg.15290_g
4008:. 26 October 2023.
3820:on 19 October 2013.
2790:2014CBio...24.R262M
2735:2011NYASA1241...17N
2493:(NGF) signaling in
2491:nerve growth factor
2487:Parkinson's disease
2467:blood–brain barrier
2274:Society and culture
2157:hydroxyde solutions
2095:
2067:
2012:Chemical properties
1959:cerebrospinal fluid
1916:Mechanism of action
1859:retrospective study
1427:Vincent's infection
1255:species infections,
1199:granuloma inguinale
1170:campylobacter fetus
1141:Haemophilus ducreyi
986:Brucella melitensis
973:General indications
816:bacterial pneumonia
309:(Prescription only)
296:(Prescription only)
25:
10977:Never to phase III
10837:Other combinations
10717:dihydroartemisinin
10499:hydroxychloroquine
10256:Never to phase III
9768:Never to phase III
7438:J Am Acad Dermatol
7389:Acta Derm Venereol
6487:Curr Mol Pharmacol
6306:on 1 January 2015.
6276:The New York Times
6234:on 1 January 2015.
6212:on 1 January 2015.
6190:on 1 January 2015.
6140:The New York Times
5901:10.1093/jac/dkl224
4606:10.5694/mja2.52258
4046:10.1093/cid/cis784
3351:on 1 February 2014
3034:(3 Pt 2): 736–41.
2824:Travelers' Malaria
2548:tetracycline class
2520:associated with a
2313:
2226:tetracycline class
2091:
2068:
2053:
1669:Chlamydia psittaci
1520:Use in combination
1408:Treponema pertenue
1396:Treponema pallidum
1374:Bacillus anthracis
1323:tetracycline group
1263:species (formerly
1010:Mycoplasma hominis
960:for uncomplicated
910:
902:
804:tetracycline class
21:
10987:
10986:
10922:
10921:
10894:
10893:
10890:
10889:
10868:
10867:
10864:
10863:
10776:
10775:
10681:
10680:
10584:
10583:
10433:
10432:
10359:Cryptosporidiosis
10266:
10265:
10225:
10224:
10049:
10048:
10003:phosphorylcholine
9953:
9952:
9778:
9777:
9737:
9736:
9733:
9732:
9445:
9444:
9336:
9335:
9332:
9331:
9241:Chlortetracycline
9209:
9208:
8926:
8925:
8844:Tibezonium iodide
8789:Hydrogen peroxide
8754:Chlortetracycline
8717:Stannous fluoride
8473:(10): 1681–1691.
7665:10.1002/jcph.2358
7444:(5): 945–73.e33.
7119:10.1159/000524762
6963:(20): 2055–2067.
6923:978-0-12-812776-6
6726:10.1038/srep32659
6637:978-3-0348-0156-0
6554:10.1111/jdv.14345
6548:(11): 1800–1808.
6078:978-0-7817-6879-5
6027:. Vol. 119.
5973:978-3-7741-9846-3
5816:978-0-7020-3471-8
5653:10.1111/imj.12179
5422:978-0-7020-5516-4
5166:10.1002/ejhf.1695
5125:978-0-323-07672-2
5036:(9477): 2116–21.
4969:978-92-4-154912-7
4895:10.4137/CMT.S2035
4550:(25): 2331–2340.
4261:(11): 1570–1581.
4087:Curr Opin Pediatr
3729:on 19 April 2014.
3244:(6): 1345–61, x.
3137:10.4137/CMT.S2035
2956:978-1-4496-0067-9
2888:978-1-118-35446-9
2875:Corey EJ (2013).
2861:978-3-527-60749-5
2834:978-1-55009-336-0
2417:hydroxyl radicals
2369:tissue remodeling
2354:neuroinflammation
2222:chlortetracycline
2218:American Cyanamid
2201:
2200:
2086:hydrochloric acid
2038:specific rotation
1764:Contraindications
1315:and up to 74% of
867:plastid organelle
790:
789:
718:Interactive image
605:CompTox Dashboard
317:
304:
291:
209:
176:
11059:
11004:
11003:
11002:
10995:
10787:
10786:
10595:
10594:
10473:
10472:
10462:
10461:
10453:
10452:
10444:
10443:
10355:
10354:
10339:
10338:
10328:
10327:
10310:antiparasitics (
10293:
10286:
10279:
10270:
10269:
10060:
10059:
9846:
9845:
9837:
9836:
9805:
9798:
9791:
9782:
9781:
9458:
9457:
9410:
9409:
9347:
9346:
9296:Rolitetracycline
9226:
9225:
9013:
9012:
8998:
8997:
8953:
8946:
8939:
8930:
8929:
8834:Sodium perborate
8769:Domiphen bromide
8666:
8659:
8652:
8643:
8642:
8631:
8630:
8602:
8596:
8595:
8570:(5218): 1766–9.
8559:
8550:
8549:
8539:
8507:
8501:
8500:
8490:
8458:
8452:
8451:
8441:
8417:
8408:
8407:
8397:
8387:
8363:
8357:
8356:
8346:
8323:Turk J Pharm Sci
8314:
8308:
8307:
8297:
8265:
8259:
8258:
8248:
8231:(9): 1010–1020.
8216:
8210:
8209:
8207:
8205:
8183:
8176:
8170:
8169:
8132:
8126:
8125:
8115:
8105:
8081:
8075:
8074:
8049:(8): 1787–1796.
8038:
8032:
8031:
8021:
8004:(4): 1889–1903.
7989:
7983:
7982:
7964:
7940:
7934:
7933:
7923:
7891:
7885:
7884:
7874:
7842:
7836:
7835:
7825:
7815:
7791:
7785:
7784:
7766:
7742:
7736:
7735:
7725:
7715:
7691:
7685:
7684:
7653:J Clin Pharmacol
7648:
7642:
7641:
7631:
7621:
7597:
7591:
7590:
7580:
7563:(3): 1035–1043.
7548:
7542:
7541:
7513:
7507:
7506:
7470:
7464:
7463:
7453:
7429:
7423:
7422:
7404:
7380:
7374:
7373:
7355:
7345:
7321:
7315:
7314:
7304:
7272:
7266:
7265:
7247:
7223:
7217:
7216:
7188:
7182:
7181:
7152:
7141:
7140:
7130:
7098:
7092:
7091:
7063:
7057:
7056:
7036:
7030:
7029:
7019:
6995:
6989:
6988:
6952:
6946:
6945:
6935:
6893:
6887:
6886:
6849:
6843:
6842:
6832:
6808:
6802:
6801:
6791:
6759:
6748:
6747:
6737:
6697:
6691:
6690:
6672:
6648:
6642:
6641:
6615:
6609:
6608:
6580:
6574:
6573:
6537:
6531:
6530:
6528:
6526:
6493:(6): 1046–1065.
6478:
6472:
6471:
6443:
6437:
6436:
6400:
6394:
6393:
6391:
6389:
6380:. Archived from
6370:
6364:
6363:
6361:
6359:
6340:
6334:
6333:
6331:
6329:
6314:
6308:
6307:
6302:. Archived from
6291:
6285:
6284:
6279:. Archived from
6266:
6260:
6259:
6242:
6236:
6235:
6220:
6214:
6213:
6198:
6192:
6191:
6176:
6170:
6169:
6154:
6148:
6147:
6146:on 6 March 2016.
6132:
6123:
6122:
6117:. Archived from
6107:
6101:
6100:
6099:(12th ed.).
6092:
6083:
6082:
6064:
6055:
6054:
6049:. Archived from
6017:
6011:
6010:
6002:
5996:
5994:
5987:
5978:
5977:
5959:
5944:
5943:
5941:
5939:
5920:
5914:
5913:
5903:
5879:
5873:
5872:
5862:
5830:
5821:
5820:
5802:
5796:
5795:
5777:
5757:
5751:
5750:
5722:
5716:
5715:
5679:
5673:
5672:
5635:
5629:
5628:
5610:
5601:
5592:
5591:
5581:
5549:
5543:
5542:
5532:
5522:
5498:
5492:
5491:
5463:
5457:
5456:
5436:
5427:
5426:
5408:
5399:
5398:
5388:
5378:
5354:
5348:
5347:
5345:
5343:
5324:
5318:
5317:
5281:
5275:
5274:
5243:Paediatric Drugs
5238:
5232:
5231:
5229:
5227:
5218:. Archived from
5207:
5201:
5200:
5192:
5179:
5178:
5168:
5144:
5138:
5137:
5111:
5105:
5104:
5102:
5100:
5094:
5083:
5075:
5062:
5061:
5024:
5018:
5017:
4980:
4974:
4973:
4956:
4950:
4949:
4939:
4929:
4905:
4899:
4898:
4878:
4872:
4871:
4861:
4829:
4823:
4822:
4820:
4818:
4799:
4793:
4792:
4790:
4788:
4769:
4763:
4762:
4760:
4758:
4740:
4731:(4): e247–e251.
4716:
4710:
4709:
4707:
4705:
4685:
4679:
4678:
4676:
4674:
4655:
4649:
4648:
4646:
4644:
4625:
4619:
4618:
4608:
4584:
4578:
4577:
4567:
4535:
4529:
4528:
4526:
4524:
4504:
4498:
4497:
4487:
4477:
4453:
4447:
4446:
4444:
4442:
4427:
4418:
4417:
4388:
4377:
4376:
4366:
4334:
4328:
4327:
4317:
4285:
4279:
4278:
4249:
4243:
4242:
4232:
4200:
4194:
4193:
4157:
4151:
4150:
4121:
4115:
4114:
4105: 10932821.
4082:
4076:
4075:
4064:
4058:
4057:
4028:
4022:
4021:
4019:
4017:
4002:
3996:
3995:
3993:
3991:
3967:
3961:
3960:
3958:
3956:
3938:
3914:
3908:
3907:
3879:
3873:
3872:
3862:
3852:
3828:
3822:
3821:
3819:
3808:
3800:
3731:
3730:
3728:
3717:
3709:
3638:
3637:
3601:
3595:
3594:
3574:
3568:
3567:
3531:
3525:
3524:
3514:
3490:
3484:
3483:
3473:
3441:
3435:
3434:
3398:
3392:
3391:
3389:
3387:
3367:
3361:
3360:
3358:
3356:
3350:
3344:. Archived from
3343:
3335:
3329:
3328:
3308:
3302:
3301:
3273:
3262:
3261:
3233:
3227:
3226:
3198:
3192:
3191:
3155:
3149:
3148:
3120:
3095:
3094:
3058:
3052:
3051:
3022:
3016:
3015:
3013:
3011:
2997:
2991:
2990:
2988:
2986:
2967:
2961:
2960:
2940:
2931:
2930:
2911:
2905:
2904:
2902:
2900:
2872:
2866:
2865:
2845:
2839:
2838:
2818:
2812:
2811:
2801:
2769:
2763:
2762:
2718:
2707:
2706:
2704:
2702:
2687:
2681:
2680:
2678:
2676:
2657:
2651:
2650:
2648:
2646:
2631:
2542:Research reagent
2096:
2090:
2077:
2075:
2074:
2069:
2066:
2061:
2036:of 2–3, and the
2020:and doxycycline
2002:Fanconi syndrome
1929:Pharmacokinetics
1232:Escherichia coli
887:
882:generic medicine
786:
785:
778:
720:
700:
685:
679:
673:
667:
650:
639:
628:
627:
613:
611:
596:
576:
556:
536:
516:
496:
476:
466:
465:
451:
371:
315:
312:
302:
299:
289:
286:
264:
254:
207:
204:
186:
175:
172:
159:
145:
113:
109:
103:
102:
99:
98:
95:
92:
89:
86:
83:
80:
77:
74:
71:
68:
65:
62:
42:
33:
26:
24:
20:
11067:
11066:
11062:
11061:
11060:
11058:
11057:
11056:
11012:
11011:
11010:
11000:
10998:
10990:
10988:
10983:
10982:
10967:Clinical trials
10946:
10929:
10918:
10901:
10886:
10860:
10838:
10832:
10782:
10772:
10721:
10688:
10677:
10660:
10637:
10599:DHFR inhibitors
10580:
10550:
10524:
10477:Aminoquinolines
10467:
10457:
10429:
10396:
10378:
10346:
10333:
10322:
10315:
10297:
10267:
10262:
10261:
10246:Clinical trials
10221:
10186:
10166:Dientamoebiasis
10160:
10129:
10045:
10022:
9949:
9916:
9903:
9841:Trypanosomiasis
9826:
9809:
9779:
9774:
9773:
9758:Clinical trials
9729:
9715:Streptogramin B
9710:Streptogramin A
9650:
9622:
9594:
9441:
9422:Chloramphenicol
9399:
9353:
9328:
9310:
9291:Penimepicycline
9286:Oxytetracycline
9217:
9205:
9189:
9128:
9004:
9002:Aminoglycosides
8987:
8957:
8927:
8922:
8882:
8859:Glucocorticoids
8856:
8854:Corticosteroids
8848:
8721:
8707:Sodium fluoride
8680:
8670:
8640:
8635:
8634:
8603:
8599:
8560:
8553:
8516:Cancer Research
8508:
8504:
8459:
8455:
8426:Eur J Pharm Sci
8418:
8411:
8364:
8360:
8315:
8311:
8266:
8262:
8217:
8213:
8203:
8201:
8188:. 31 May 2022.
8178:
8177:
8173:
8138:Behav Brain Res
8133:
8129:
8082:
8078:
8039:
8035:
7990:
7986:
7941:
7937:
7892:
7888:
7843:
7839:
7792:
7788:
7743:
7739:
7692:
7688:
7649:
7645:
7598:
7594:
7549:
7545:
7518:Am J Kidney Dis
7514:
7510:
7471:
7467:
7430:
7426:
7381:
7377:
7322:
7318:
7273:
7269:
7224:
7220:
7189:
7185:
7158:J Affect Disord
7153:
7144:
7099:
7095:
7064:
7060:
7037:
7033:
6996:
6992:
6953:
6949:
6924:
6894:
6890:
6850:
6846:
6809:
6805:
6760:
6751:
6698:
6694:
6649:
6645:
6638:
6616:
6612:
6581:
6577:
6538:
6534:
6524:
6522:
6479:
6475:
6444:
6440:
6401:
6397:
6387:
6385:
6372:
6371:
6367:
6357:
6355:
6342:
6341:
6337:
6327:
6325:
6316:
6315:
6311:
6292:
6288:
6267:
6263:
6244:
6243:
6239:
6222:
6221:
6217:
6200:
6199:
6195:
6178:
6177:
6173:
6156:
6155:
6151:
6134:
6133:
6126:
6109:
6108:
6104:
6093:
6086:
6079:
6065:
6058:
6053:on 10 May 2011.
6039:
6019:
6018:
6014:
6003:
5999:
5988:
5981:
5974:
5960:
5947:
5937:
5935:
5928:www.drugbank.ca
5922:
5921:
5917:
5880:
5876:
5845:(11): 3547–54.
5831:
5824:
5817:
5803:
5799:
5775:10.1.1.620.9933
5758:
5754:
5723:
5719:
5680:
5676:
5636:
5632:
5608:
5602:
5595:
5550:
5546:
5499:
5495:
5468:Human Pathology
5464:
5460:
5437:
5430:
5423:
5409:
5402:
5363:Malaria Journal
5355:
5351:
5341:
5339:
5326:
5325:
5321:
5282:
5278:
5239:
5235:
5225:
5223:
5208:
5204:
5193:
5182:
5145:
5141:
5126:
5112:
5108:
5098:
5096:
5092:
5081:
5077:
5076:
5065:
5025:
5021:
4981:
4977:
4970:
4958:
4957:
4953:
4906:
4902:
4879:
4875:
4830:
4826:
4816:
4814:
4801:
4800:
4796:
4786:
4784:
4771:
4770:
4766:
4756:
4754:
4717:
4713:
4703:
4701:
4686:
4682:
4672:
4670:
4657:
4656:
4652:
4642:
4640:
4627:
4626:
4622:
4585:
4581:
4536:
4532:
4522:
4520:
4505:
4501:
4454:
4450:
4440:
4438:
4429:
4428:
4421:
4389:
4380:
4349:(1): CD009436.
4335:
4331:
4300:(4): CD003262.
4286:
4282:
4250:
4246:
4215:(8): CD002086.
4201:
4197:
4158:
4154:
4122:
4118:
4083:
4079:
4066:
4065:
4061:
4029:
4025:
4015:
4013:
4004:
4003:
3999:
3989:
3987:
3968:
3964:
3954:
3952:
3915:
3911:
3894:(RR-03): 1–30.
3880:
3876:
3829:
3825:
3817:
3806:
3802:
3801:
3734:
3726:
3715:
3711:
3710:
3641:
3602:
3598:
3575:
3571:
3532:
3528:
3491:
3487:
3442:
3438:
3399:
3395:
3385:
3383:
3372:"Leptospirosis"
3368:
3364:
3354:
3352:
3348:
3341:
3337:
3336:
3332:
3309:
3305:
3274:
3265:
3234:
3230:
3199:
3195:
3156:
3152:
3121:
3098:
3059:
3055:
3023:
3019:
3009:
3007:
2999:
2998:
2994:
2984:
2982:
2969:
2968:
2964:
2957:
2941:
2934:
2912:
2908:
2898:
2896:
2889:
2873:
2869:
2862:
2846:
2842:
2835:
2819:
2815:
2778:Current Biology
2770:
2766:
2719:
2710:
2700:
2698:
2689:
2688:
2684:
2674:
2672:
2659:
2658:
2654:
2644:
2642:
2633:
2632:
2609:
2604:
2576:gene expression
2544:
2531:
2510:COVID‑19
2318:
2284:
2276:
2230:oxytetracycline
2206:
2062:
2057:
2045:
2042:
2041:
2032:solution has a
2014:
1998:
1935:small intestine
1931:
1918:
1894:
1888:
1871:
1863:Crohn's disease
1857:. In one large
1818:
1816:Adverse effects
1790:
1766:
1747:
1731:
1707:
1696:: 0.06–32
1684:: 0.016–2
1639:
1600:
1542:
1522:
1502:
1464:
1384:
1303:
1220:
1150:Yersinia pestis
1124:relapsing fever
1022:Yersinia pestis
975:
970:
894:
885:
781:
779:
776:(what is this?)
773:
768:
765:
760:
755:
754:
743:
740:
735:
734:
723:
698:
688:
682:
676:
670:
631:
607:
599:
579:
559:
539:
519:
499:
479:
462:
454:
434:
431:
402:
401:
369:
348:Protein binding
338:Bioavailability
330:Pharmacokinetic
324:
268:
222:
215:
196:
189:
111:
107:
104:
59:
55:
17:
12:
11:
5:
11065:
11055:
11054:
11049:
11044:
11039:
11034:
11029:
11024:
11009:
11008:
10985:
10984:
10981:
10980:
10979:
10978:
10975:
10964:
10958:
10952:
10951:
10948:
10947:
10945:
10944:
10938:Blastocystosis
10934:
10932:
10924:
10923:
10920:
10919:
10917:
10916:
10906:
10904:
10896:
10895:
10892:
10891:
10888:
10887:
10885:
10884:
10878:
10876:
10870:
10869:
10866:
10865:
10862:
10861:
10859:
10858:
10855:
10852:
10849:
10846:
10842:
10840:
10834:
10833:
10831:
10830:
10825:
10820:
10814:
10808:
10802:
10796:
10794:
10784:
10778:
10777:
10774:
10773:
10771:
10770:
10765:
10760:
10755:
10750:
10745:
10740:
10729:
10727:
10723:
10722:
10720:
10719:
10714:
10709:
10704:
10699:
10693:
10691:
10683:
10682:
10679:
10678:
10676:
10675:
10668:
10666:
10665:Co-formulation
10662:
10661:
10659:
10658:
10653:
10647:
10645:
10639:
10638:
10636:
10635:
10634:
10633:
10628:
10626:chlorproguanil
10615:
10614:
10609:
10603:
10601:
10592:
10586:
10585:
10582:
10581:
10579:
10578:
10572:
10571:
10570:
10569:
10558:
10556:
10552:
10551:
10549:
10548:
10543:
10538:
10532:
10530:
10526:
10525:
10523:
10522:
10517:
10512:
10502:
10501:
10496:
10491:
10481:
10479:
10470:
10459:
10450:
10441:
10435:
10434:
10431:
10430:
10428:
10427:
10422:
10417:
10412:
10406:
10404:
10398:
10397:
10395:
10394:
10388:
10386:
10380:
10379:
10377:
10376:
10363:
10361:
10352:
10336:
10325:
10317:
10316:
10308:Chromalveolata
10300:Antiparasitics
10296:
10295:
10288:
10281:
10273:
10264:
10263:
10260:
10259:
10258:
10257:
10254:
10243:
10237:
10231:
10230:
10227:
10226:
10223:
10222:
10220:
10219:
10209:
10199:
10188:
10187:
10180:
10174:nitroimidazole
10170:
10168:
10162:
10161:
10159:
10158:
10143:nitroimidazole
10139:
10137:
10135:Trichomoniasis
10131:
10130:
10128:
10127:
10116:
10115:
10105:
10094:
10093:
10083:
10072:nitroimidazole
10068:
10066:
10057:
10051:
10050:
10047:
10046:
10044:
10043:
10040:Amphotericin B
10032:
10030:
10024:
10023:
10021:
10020:
10010:
10000:
9975:
9974:
9971:Amphotericin B
9963:
9961:
9955:
9954:
9951:
9950:
9948:
9947:
9937:
9930:nitroimidazole
9926:
9924:
9922:Chagas disease
9918:
9917:
9915:
9914:
9907:nitroimidazole
9904:
9893:
9883:
9865:
9854:
9852:
9843:
9834:
9828:
9827:
9812:Antiparasitics
9808:
9807:
9800:
9793:
9785:
9776:
9775:
9772:
9771:
9770:
9769:
9766:
9755:
9749:
9743:
9742:
9739:
9738:
9735:
9734:
9731:
9730:
9728:
9727:
9717:
9712:
9707:
9693:
9679:
9660:
9658:
9656:Streptogramins
9652:
9651:
9649:
9648:
9643:
9638:
9632:
9630:
9624:
9623:
9621:
9620:
9615:
9610:
9604:
9602:
9596:
9595:
9593:
9592:
9587:
9582:
9577:
9575:Troleandomycin
9572:
9567:
9562:
9557:
9552:
9547:
9542:
9537:
9532:
9527:
9522:
9517:
9512:
9507:
9505:Flurithromycin
9502:
9497:
9492:
9490:Clarithromycin
9487:
9482:
9477:
9472:
9466:
9464:
9455:
9447:
9446:
9443:
9442:
9440:
9439:
9434:
9429:
9424:
9418:
9416:
9407:
9401:
9400:
9398:
9397:
9392:
9387:
9382:
9377:
9372:
9367:
9361:
9359:
9344:
9338:
9337:
9334:
9333:
9330:
9329:
9327:
9326:
9320:
9318:
9316:Glycylcyclines
9312:
9311:
9309:
9308:
9303:
9298:
9293:
9288:
9283:
9278:
9273:
9268:
9263:
9258:
9253:
9251:Demeclocycline
9248:
9243:
9238:
9232:
9230:
9223:
9211:
9210:
9207:
9206:
9204:
9203:
9197:
9195:
9191:
9190:
9188:
9187:
9182:
9176:
9175:
9174:
9173:
9168:
9163:
9158:
9153:
9142:
9140:
9136:Micromonospora
9130:
9129:
9127:
9126:
9124:Nourseothricin
9121:
9116:
9111:
9106:
9101:
9090:
9089:
9088:
9087:
9082:
9077:
9072:
9061:
9060:
9059:
9058:
9053:
9048:
9037:
9036:
9031:
9025:
9023:
9010:
8995:
8989:
8988:
8960:Antibacterials
8956:
8955:
8948:
8941:
8933:
8924:
8923:
8921:
8920:
8911:
8906:
8901:
8896:
8890:
8888:
8884:
8883:
8881:
8880:
8875:
8873:Hydrocortisone
8870:
8864:
8862:
8850:
8849:
8847:
8846:
8841:
8836:
8831:
8826:
8821:
8816:
8811:
8806:
8801:
8796:
8791:
8786:
8781:
8776:
8771:
8766:
8761:
8756:
8751:
8746:
8741:
8739:Amphotericin B
8735:
8733:
8723:
8722:
8720:
8719:
8714:
8709:
8704:
8699:
8693:
8691:
8682:
8681:
8675:preparations (
8673:Stomatological
8669:
8668:
8661:
8654:
8646:
8639:
8638:External links
8636:
8633:
8632:
8597:
8551:
8522:(21): 4446–9.
8502:
8453:
8409:
8358:
8329:(1): 101–103.
8309:
8280:(5): 566–572.
8260:
8211:
8171:
8127:
8090:BMC Psychiatry
8076:
8033:
7984:
7955:(4): 981–986.
7935:
7906:(4): 953–961.
7900:Schizophr Bull
7886:
7857:(5): 475–482.
7837:
7786:
7737:
7686:
7659:(2): 164–177.
7643:
7592:
7543:
7508:
7465:
7424:
7375:
7336:(2): E24–E29.
7316:
7267:
7238:(7): 561–566.
7218:
7183:
7142:
7113:(6): 476–481.
7093:
7058:
7031:
6990:
6947:
6922:
6888:
6861:(4): 1128–36.
6844:
6823:(6): 1376–83.
6803:
6749:
6692:
6643:
6636:
6610:
6585:Drugs of Today
6575:
6532:
6473:
6438:
6395:
6384:on 16 May 2015
6365:
6335:
6309:
6286:
6261:
6237:
6215:
6193:
6171:
6149:
6124:
6102:
6084:
6077:
6056:
6037:
6012:
5997:
5979:
5972:
5945:
5915:
5874:
5822:
5815:
5797:
5752:
5717:
5690:(12): 2610–6.
5674:
5630:
5593:
5544:
5493:
5458:
5428:
5421:
5400:
5349:
5319:
5276:
5249:(12): 817–37.
5233:
5202:
5180:
5139:
5124:
5106:
5063:
5019:
4975:
4968:
4951:
4900:
4873:
4844:(9): 3124–31.
4824:
4794:
4764:
4711:
4680:
4650:
4620:
4599:(7): 381–386.
4579:
4530:
4499:
4462:BMC Infect Dis
4448:
4419:
4400:(2): 167–176.
4378:
4329:
4280:
4244:
4195:
4152:
4116:
4093:(2): 156–163.
4077:
4059:
4040:(12): 1642–9.
4023:
3997:
3962:
3909:
3874:
3837:BMC Infect Dis
3823:
3732:
3639:
3596:
3569:
3526:
3485:
3436:
3393:
3362:
3330:
3303:
3284:(5): 407–421.
3263:
3228:
3193:
3150:
3096:
3053:
3017:
2992:
2962:
2955:
2932:
2906:
2887:
2867:
2860:
2840:
2833:
2813:
2764:
2708:
2682:
2665:Fit for Travel
2652:
2606:
2605:
2603:
2600:
2543:
2540:
2530:
2527:
2518:cytokine storm
2463:anti-apoptotic
2436:osteoarthritis
2421:singlet oxygen
2404:bacteriostatic
2400:ocular rosacea
2342:interleukin-10
2317:
2314:
2305:
2304:
2294:
2283:
2280:
2275:
2272:
2214:bioprospecting
2205:
2202:
2199:
2198:
2195:
2192:
2189:
2183:
2182:
2179:
2176:
2173:
2167:
2166:
2164:
2161:
2158:
2151:
2150:
2148:
2145:
2142:
2138:
2137:
2134:
2131:
2128:
2124:
2123:
2120:
2117:
2114:
2110:
2109:
2106:
2103:
2100:
2065:
2060:
2056:
2052:
2049:
2013:
2010:
1997:
1994:
1943:plasma protein
1930:
1927:
1922:bacteriostatic
1917:
1914:
1906:kidney failure
1898:bacteriostatic
1887:
1884:
1870:
1867:
1817:
1814:
1789:
1786:
1765:
1762:
1746:
1743:
1730:
1727:
1706:
1703:
1702:
1701:
1689:
1677:
1638:
1635:
1623:onchocerciasis
1599:
1598:Antihelminthic
1596:
1541:
1538:
1521:
1518:
1501:
1498:
1463:
1460:
1459:
1458:
1449:
1437:
1424:
1412:
1400:
1383:
1380:
1379:
1378:
1366:
1350:
1302:
1299:
1298:
1297:
1284:
1272:
1256:
1248:
1236:
1219:
1216:
1215:
1214:
1208:
1196:
1190:
1174:
1166:
1160:
1154:
1147:plague due to
1145:
1133:
1121:
1109:
1103:
1083:
1074:
1065:rickettsialpox
1027:bubonic plague
974:
971:
969:
966:
893:
890:
797:broad-spectrum
788:
787:
770:
769:
767:
766:
763:
761:
758:
750:
749:
748:
745:
744:
742:
741:
738:
730:
729:
728:
725:
724:
722:
721:
713:
711:
703:
702:
696:
690:
689:
686:
680:
674:
668:
663:
657:
656:
652:
651:
641:
633:
632:
630:
629:
616:
614:
601:
600:
598:
597:
589:
587:
581:
580:
578:
577:
569:
567:
561:
560:
558:
557:
549:
547:
541:
540:
538:
537:
529:
527:
521:
520:
518:
517:
509:
507:
501:
500:
498:
497:
489:
487:
481:
480:
478:
477:
469:
467:
456:
455:
453:
452:
444:
442:
436:
435:
433:
432:
405:
397:
396:
395:
392:
391:
387:
386:
383:
377:
376:
373:
364:
363:
360:
354:
353:
350:
344:
343:
340:
334:
333:
326:
325:
323:
322:
310:
297:
283:
281:
275:
274:
270:
269:
267:
266:
243:
241:
235:
234:
225:
223:administration
217:
216:
214:
213:
211:
201:
199:
191:
190:
188:
187:
169:
167:
161:
160:
153:
147:
146:
139:
129:
128:
125:
119:
118:
53:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
11064:
11053:
11050:
11048:
11045:
11043:
11040:
11038:
11035:
11033:
11030:
11028:
11025:
11023:
11020:
11019:
11017:
11007:
10997:
10996:
10993:
10976:
10974:
10971:
10970:
10968:
10965:
10962:
10959:
10957:
10954:
10953:
10949:
10943:
10942:metronidazole
10939:
10936:
10935:
10933:
10931:
10925:
10915:
10911:
10910:Balantidiasis
10908:
10907:
10905:
10903:
10897:
10883:
10880:
10879:
10877:
10875:
10871:
10856:
10853:
10850:
10848:artesunate/SP
10847:
10844:
10843:
10841:
10835:
10829:
10826:
10824:
10821:
10818:
10815:
10812:
10809:
10806:
10803:
10801:
10798:
10797:
10795:
10793:
10788:
10785:
10779:
10769:
10766:
10764:
10761:
10759:
10756:
10754:
10751:
10749:
10746:
10744:
10741:
10738:
10734:
10731:
10730:
10728:
10724:
10718:
10715:
10713:
10710:
10708:
10705:
10703:
10700:
10698:
10695:
10694:
10692:
10690:
10687:Sesquiterpene
10684:
10673:
10670:
10669:
10667:
10663:
10657:
10654:
10652:
10649:
10648:
10646:
10644:
10640:
10632:
10629:
10627:
10624:
10623:
10622:
10621:
10617:
10616:
10613:
10610:
10608:
10607:pyrimethamine
10605:
10604:
10602:
10600:
10596:
10593:
10591:
10587:
10577:
10574:
10573:
10568:
10565:
10564:
10563:
10560:
10559:
10557:
10553:
10547:
10544:
10542:
10539:
10537:
10534:
10533:
10531:
10527:
10521:
10518:
10516:
10513:
10511:
10507:
10504:
10503:
10500:
10497:
10495:
10492:
10490:
10486:
10483:
10482:
10480:
10478:
10474:
10471:
10469:
10463:
10460:
10454:
10451:
10449:
10445:
10442:
10440:
10436:
10426:
10423:
10421:
10418:
10416:
10413:
10411:
10410:pyrimethamine
10408:
10407:
10405:
10403:
10402:Toxoplasmosis
10399:
10393:
10390:
10389:
10387:
10385:
10381:
10374:
10370:
10369:
10365:
10364:
10362:
10360:
10356:
10353:
10350:
10349:Coccidiostats
10344:
10340:
10337:
10335:
10329:
10326:
10324:
10318:
10313:
10309:
10305:
10301:
10294:
10289:
10287:
10282:
10280:
10275:
10274:
10271:
10255:
10253:
10250:
10249:
10247:
10244:
10241:
10238:
10236:
10233:
10232:
10228:
10217:
10213:
10210:
10207:
10203:
10200:
10197:
10193:
10190:
10189:
10184:
10181:
10179:
10178:Metronidazole
10175:
10172:
10171:
10169:
10167:
10163:
10156:
10152:
10151:Metronidazole
10148:
10144:
10141:
10140:
10138:
10136:
10132:
10125:
10121:
10120:aminoacridine
10118:
10117:
10113:
10109:
10106:
10103:
10099:
10096:
10095:
10091:
10087:
10086:benzimidazole
10084:
10081:
10077:
10076:Metronidazole
10073:
10070:
10069:
10067:
10065:
10061:
10058:
10056:
10052:
10041:
10037:
10034:
10033:
10031:
10029:
10025:
10018:
10014:
10011:
10008:
10004:
10001:
9998:
9994:
9991:
9990:
9989:
9987:
9983:
9979:
9972:
9968:
9965:
9964:
9962:
9960:
9959:Leishmaniasis
9956:
9945:
9941:
9938:
9935:
9931:
9928:
9927:
9925:
9923:
9919:
9912:
9908:
9905:
9901:
9897:
9894:
9891:
9887:
9884:
9881:
9877:
9873:
9869:
9866:
9863:
9859:
9856:
9855:
9853:
9851:
9847:
9844:
9842:
9838:
9835:
9833:
9832:Discicristata
9829:
9824:
9820:
9817:
9813:
9806:
9801:
9799:
9794:
9792:
9787:
9786:
9783:
9767:
9765:
9762:
9761:
9759:
9756:
9753:
9750:
9748:
9745:
9744:
9740:
9725:
9721:
9720:Virginiamycin
9718:
9716:
9713:
9711:
9708:
9705:
9701:
9697:
9694:
9691:
9687:
9683:
9680:
9677:
9673:
9669:
9665:
9664:Pristinamycin
9662:
9661:
9659:
9657:
9653:
9647:
9644:
9642:
9639:
9637:
9634:
9633:
9631:
9629:
9625:
9619:
9618:Solithromycin
9616:
9614:
9611:
9609:
9608:Telithromycin
9606:
9605:
9603:
9601:
9597:
9591:
9588:
9586:
9583:
9581:
9580:Tulathromycin
9578:
9576:
9573:
9571:
9568:
9566:
9563:
9561:
9560:Telithromycin
9558:
9556:
9553:
9551:
9550:Solithromycin
9548:
9546:
9545:Roxithromycin
9543:
9541:
9538:
9536:
9533:
9531:
9528:
9526:
9523:
9521:
9518:
9516:
9513:
9511:
9510:Gamithromycin
9508:
9506:
9503:
9501:
9498:
9496:
9495:Dirithromycin
9493:
9491:
9488:
9486:
9483:
9481:
9478:
9476:
9473:
9471:
9468:
9467:
9465:
9463:
9459:
9456:
9453:
9448:
9438:
9435:
9433:
9432:Thiamphenicol
9430:
9428:
9427:Azidamfenicol
9425:
9423:
9420:
9419:
9417:
9415:
9411:
9408:
9406:
9402:
9396:
9393:
9391:
9388:
9386:
9383:
9381:
9378:
9376:
9373:
9371:
9368:
9366:
9363:
9362:
9360:
9357:
9352:
9351:Oxazolidinone
9348:
9345:
9343:
9339:
9325:
9322:
9321:
9319:
9317:
9313:
9307:
9304:
9302:
9299:
9297:
9294:
9292:
9289:
9287:
9284:
9282:
9279:
9277:
9274:
9272:
9269:
9267:
9264:
9262:
9259:
9257:
9254:
9252:
9249:
9247:
9244:
9242:
9239:
9237:
9234:
9233:
9231:
9229:Tetracyclines
9227:
9224:
9221:
9216:
9212:
9202:
9199:
9198:
9196:
9192:
9186:
9183:
9181:
9178:
9177:
9172:
9169:
9167:
9164:
9162:
9159:
9157:
9154:
9152:
9149:
9148:
9147:
9144:
9143:
9141:
9138:
9137:
9131:
9125:
9122:
9120:
9117:
9115:
9112:
9110:
9107:
9105:
9104:Spectinomycin
9102:
9099:
9095:
9092:
9091:
9086:
9083:
9081:
9078:
9076:
9073:
9071:
9068:
9067:
9066:
9063:
9062:
9057:
9054:
9052:
9049:
9047:
9044:
9043:
9042:
9039:
9038:
9035:
9032:
9030:
9027:
9026:
9024:
9021:
9020:
9014:
9011:
9008:
9003:
8999:
8996:
8994:
8990:
8985:
8981:
8977:
8973:
8969:
8965:
8961:
8954:
8949:
8947:
8942:
8940:
8935:
8934:
8931:
8919:
8915:
8912:
8910:
8907:
8905:
8902:
8900:
8897:
8895:
8892:
8891:
8889:
8885:
8879:
8878:Triamcinolone
8876:
8874:
8871:
8869:
8868:Dexamethasone
8866:
8865:
8863:
8860:
8855:
8851:
8845:
8842:
8840:
8837:
8835:
8832:
8830:
8827:
8825:
8822:
8820:
8817:
8815:
8812:
8810:
8807:
8805:
8802:
8800:
8799:Metronidazole
8797:
8795:
8792:
8790:
8787:
8785:
8782:
8780:
8777:
8775:
8772:
8770:
8767:
8765:
8762:
8760:
8757:
8755:
8752:
8750:
8749:Chlorhexidine
8747:
8745:
8742:
8740:
8737:
8736:
8734:
8732:
8728:
8724:
8718:
8715:
8713:
8710:
8708:
8705:
8703:
8700:
8698:
8695:
8694:
8692:
8690:
8687:
8683:
8678:
8674:
8667:
8662:
8660:
8655:
8653:
8648:
8647:
8644:
8628:
8624:
8620:
8616:
8612:
8608:
8601:
8593:
8589:
8585:
8581:
8577:
8573:
8569:
8565:
8558:
8556:
8547:
8543:
8538:
8533:
8529:
8525:
8521:
8517:
8513:
8506:
8498:
8494:
8489:
8484:
8480:
8476:
8472:
8468:
8464:
8457:
8449:
8445:
8440:
8435:
8431:
8427:
8423:
8416:
8414:
8405:
8401:
8396:
8391:
8386:
8381:
8378:: 1023–1026.
8377:
8373:
8369:
8362:
8354:
8350:
8345:
8340:
8336:
8332:
8328:
8324:
8320:
8313:
8305:
8301:
8296:
8291:
8287:
8283:
8279:
8275:
8271:
8264:
8256:
8252:
8247:
8242:
8238:
8234:
8230:
8226:
8222:
8215:
8199:
8195:
8191:
8187:
8186:NIHR Evidence
8182:
8175:
8167:
8163:
8159:
8155:
8151:
8147:
8143:
8139:
8131:
8123:
8119:
8114:
8109:
8104:
8099:
8095:
8091:
8087:
8080:
8072:
8068:
8064:
8060:
8056:
8052:
8048:
8044:
8037:
8029:
8025:
8020:
8015:
8011:
8007:
8003:
7999:
7998:Mol Neurobiol
7995:
7988:
7980:
7976:
7972:
7968:
7963:
7958:
7954:
7950:
7946:
7939:
7931:
7927:
7922:
7917:
7913:
7909:
7905:
7901:
7897:
7890:
7882:
7878:
7873:
7868:
7864:
7860:
7856:
7852:
7848:
7841:
7833:
7829:
7824:
7819:
7814:
7809:
7805:
7801:
7800:Front Immunol
7797:
7790:
7782:
7778:
7774:
7770:
7765:
7760:
7756:
7752:
7748:
7741:
7733:
7729:
7724:
7719:
7714:
7709:
7705:
7701:
7697:
7690:
7682:
7678:
7674:
7670:
7666:
7662:
7658:
7654:
7647:
7639:
7635:
7630:
7625:
7620:
7615:
7611:
7607:
7603:
7596:
7588:
7584:
7579:
7574:
7570:
7566:
7562:
7558:
7554:
7547:
7539:
7535:
7531:
7527:
7524:(2): 376–80.
7523:
7519:
7512:
7504:
7500:
7496:
7492:
7488:
7484:
7480:
7476:
7469:
7461:
7457:
7452:
7447:
7443:
7439:
7435:
7428:
7420:
7416:
7412:
7408:
7403:
7398:
7394:
7390:
7386:
7379:
7371:
7367:
7363:
7359:
7354:
7349:
7344:
7339:
7335:
7331:
7327:
7320:
7312:
7308:
7303:
7298:
7294:
7290:
7286:
7282:
7278:
7271:
7263:
7259:
7255:
7251:
7246:
7241:
7237:
7233:
7229:
7222:
7214:
7210:
7206:
7202:
7199:(4): 234–45.
7198:
7194:
7187:
7179:
7175:
7171:
7167:
7163:
7159:
7156:depression".
7151:
7149:
7147:
7138:
7134:
7129:
7124:
7120:
7116:
7112:
7108:
7104:
7097:
7089:
7085:
7081:
7077:
7073:
7069:
7062:
7054:
7050:
7046:
7042:
7035:
7027:
7023:
7018:
7013:
7009:
7005:
7001:
6994:
6986:
6982:
6978:
6974:
6970:
6966:
6962:
6958:
6951:
6943:
6939:
6934:
6929:
6925:
6919:
6915:
6911:
6907:
6903:
6899:
6892:
6884:
6880:
6876:
6872:
6868:
6864:
6860:
6856:
6855:Mol Pharmacol
6848:
6840:
6836:
6831:
6826:
6822:
6818:
6814:
6807:
6799:
6795:
6790:
6785:
6781:
6777:
6773:
6769:
6765:
6758:
6756:
6754:
6745:
6741:
6736:
6731:
6727:
6723:
6719:
6715:
6711:
6707:
6703:
6696:
6688:
6684:
6680:
6676:
6671:
6666:
6662:
6658:
6654:
6647:
6639:
6633:
6629:
6625:
6621:
6614:
6606:
6602:
6598:
6594:
6590:
6586:
6579:
6571:
6567:
6563:
6559:
6555:
6551:
6547:
6543:
6536:
6520:
6516:
6512:
6508:
6504:
6500:
6496:
6492:
6488:
6484:
6477:
6469:
6465:
6461:
6457:
6453:
6449:
6442:
6434:
6430:
6426:
6422:
6418:
6414:
6411:(5): 565–79.
6410:
6406:
6399:
6383:
6379:
6375:
6369:
6353:
6349:
6345:
6339:
6323:
6319:
6313:
6305:
6301:
6297:
6290:
6282:
6278:
6277:
6272:
6265:
6257:
6253:
6252:
6247:
6241:
6233:
6229:
6225:
6219:
6211:
6207:
6203:
6197:
6189:
6185:
6181:
6175:
6167:
6163:
6159:
6153:
6145:
6141:
6137:
6131:
6129:
6120:
6116:
6112:
6106:
6098:
6091:
6089:
6080:
6074:
6070:
6063:
6061:
6052:
6048:
6044:
6040:
6038:92-4-157119-5
6034:
6031:(WHO). 1991.
6030:
6026:
6022:
6016:
6008:
6007:Austria-Codex
6001:
5993:
5986:
5984:
5975:
5969:
5965:
5958:
5956:
5954:
5952:
5950:
5933:
5929:
5925:
5924:"Doxycycline"
5919:
5911:
5907:
5902:
5897:
5894:(2): 256–65.
5893:
5889:
5885:
5878:
5870:
5866:
5861:
5856:
5852:
5848:
5844:
5840:
5836:
5829:
5827:
5818:
5812:
5808:
5801:
5793:
5789:
5785:
5781:
5776:
5771:
5768:(4): 653–64.
5767:
5763:
5756:
5748:
5744:
5740:
5736:
5733:(6): 917–23.
5732:
5728:
5721:
5713:
5709:
5705:
5701:
5697:
5693:
5689:
5685:
5678:
5670:
5666:
5662:
5658:
5654:
5650:
5647:(8): 919–26.
5646:
5642:
5634:
5626:
5622:
5618:
5614:
5607:
5600:
5598:
5589:
5585:
5580:
5575:
5571:
5567:
5564:(4): 517–31.
5563:
5559:
5555:
5548:
5540:
5536:
5531:
5526:
5521:
5516:
5513:(2): 216–29.
5512:
5508:
5504:
5497:
5489:
5485:
5481:
5477:
5473:
5469:
5462:
5454:
5450:
5447:(5): 431–43.
5446:
5442:
5435:
5433:
5424:
5418:
5414:
5407:
5405:
5396:
5392:
5387:
5382:
5377:
5372:
5368:
5364:
5360:
5353:
5337:
5333:
5329:
5323:
5315:
5311:
5307:
5303:
5299:
5295:
5291:
5287:
5280:
5272:
5268:
5264:
5260:
5256:
5252:
5248:
5244:
5237:
5221:
5217:
5213:
5206:
5198:
5197:Austria-Codex
5191:
5189:
5187:
5185:
5176:
5172:
5167:
5162:
5158:
5154:
5150:
5143:
5135:
5131:
5127:
5121:
5117:
5110:
5091:
5087:
5080:
5074:
5072:
5070:
5068:
5059:
5055:
5051:
5047:
5043:
5039:
5035:
5031:
5023:
5015:
5011:
5007:
5003:
4999:
4995:
4991:
4987:
4979:
4971:
4965:
4961:
4955:
4947:
4943:
4938:
4933:
4928:
4923:
4919:
4915:
4911:
4904:
4896:
4892:
4889:: CMT.S2035.
4888:
4884:
4877:
4869:
4865:
4860:
4855:
4851:
4847:
4843:
4839:
4835:
4828:
4812:
4808:
4804:
4798:
4782:
4778:
4774:
4768:
4752:
4748:
4744:
4739:
4734:
4730:
4726:
4722:
4715:
4699:
4695:
4691:
4684:
4668:
4664:
4660:
4654:
4638:
4634:
4630:
4624:
4616:
4612:
4607:
4602:
4598:
4594:
4590:
4583:
4575:
4571:
4566:
4561:
4557:
4553:
4549:
4545:
4541:
4534:
4518:
4514:
4510:
4503:
4495:
4491:
4486:
4481:
4476:
4471:
4467:
4463:
4459:
4452:
4436:
4432:
4426:
4424:
4415:
4411:
4407:
4403:
4399:
4395:
4387:
4385:
4383:
4374:
4370:
4365:
4360:
4356:
4352:
4348:
4344:
4340:
4333:
4325:
4321:
4316:
4311:
4307:
4303:
4299:
4295:
4291:
4284:
4276:
4272:
4268:
4264:
4260:
4256:
4248:
4240:
4236:
4231:
4226:
4222:
4218:
4214:
4210:
4206:
4199:
4191:
4187:
4183:
4179:
4175:
4171:
4167:
4163:
4156:
4148:
4144:
4140:
4136:
4133:(2): 116215.
4132:
4128:
4120:
4112:
4108:
4104:
4100:
4096:
4092:
4088:
4081:
4073:
4069:
4063:
4055:
4051:
4047:
4043:
4039:
4035:
4027:
4011:
4007:
4001:
3985:
3981:
3977:
3973:
3966:
3950:
3946:
3942:
3937:
3932:
3928:
3924:
3920:
3913:
3905:
3901:
3897:
3893:
3889:
3885:
3878:
3870:
3866:
3861:
3856:
3851:
3846:
3842:
3838:
3834:
3827:
3816:
3812:
3805:
3799:
3797:
3795:
3793:
3791:
3789:
3787:
3785:
3783:
3781:
3779:
3777:
3775:
3773:
3771:
3769:
3767:
3765:
3763:
3761:
3759:
3757:
3755:
3753:
3751:
3749:
3747:
3745:
3743:
3741:
3739:
3737:
3725:
3721:
3714:
3708:
3706:
3704:
3702:
3700:
3698:
3696:
3694:
3692:
3690:
3688:
3686:
3684:
3682:
3680:
3678:
3676:
3674:
3672:
3670:
3668:
3666:
3664:
3662:
3660:
3658:
3656:
3654:
3652:
3650:
3648:
3646:
3644:
3635:
3631:
3627:
3623:
3619:
3615:
3611:
3607:
3600:
3592:
3588:
3585:(6): 1971–6.
3584:
3580:
3573:
3565:
3561:
3557:
3553:
3549:
3545:
3542:(7): 1203–7.
3541:
3537:
3530:
3522:
3518:
3513:
3508:
3504:
3500:
3496:
3489:
3481:
3477:
3472:
3467:
3463:
3459:
3455:
3451:
3447:
3440:
3432:
3428:
3424:
3420:
3416:
3412:
3409:(4): 273–80.
3408:
3404:
3397:
3381:
3377:
3373:
3366:
3347:
3340:
3334:
3326:
3322:
3318:
3314:
3307:
3299:
3295:
3291:
3287:
3283:
3279:
3272:
3270:
3268:
3259:
3255:
3251:
3247:
3243:
3239:
3232:
3224:
3220:
3216:
3212:
3208:
3204:
3197:
3189:
3185:
3181:
3177:
3173:
3169:
3166:(8): 957–62.
3165:
3161:
3154:
3146:
3142:
3138:
3134:
3131:: CMT.S2035.
3130:
3126:
3119:
3117:
3115:
3113:
3111:
3109:
3107:
3105:
3103:
3101:
3092:
3088:
3084:
3080:
3076:
3072:
3068:
3064:
3057:
3049:
3045:
3041:
3037:
3033:
3029:
3021:
3006:
3002:
2996:
2980:
2976:
2972:
2966:
2958:
2952:
2948:
2947:
2939:
2937:
2928:
2924:
2920:
2916:
2910:
2894:
2890:
2884:
2880:
2879:
2871:
2863:
2857:
2853:
2852:
2844:
2836:
2830:
2826:
2825:
2817:
2809:
2805:
2800:
2795:
2791:
2787:
2784:(7): R262-3.
2783:
2779:
2775:
2768:
2760:
2756:
2752:
2748:
2744:
2740:
2736:
2732:
2728:
2724:
2717:
2715:
2713:
2696:
2692:
2686:
2670:
2666:
2662:
2656:
2640:
2636:
2630:
2628:
2626:
2624:
2622:
2620:
2618:
2616:
2614:
2612:
2607:
2599:
2597:
2593:
2589:
2588:cell cultures
2585:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2549:
2539:
2535:
2529:Wound healing
2526:
2523:
2519:
2515:
2511:
2506:
2504:
2500:
2496:
2492:
2488:
2484:
2480:
2476:
2472:
2468:
2464:
2460:
2455:
2453:
2452:periodontitis
2449:
2445:
2441:
2440:periodontitis
2437:
2433:
2428:
2426:
2422:
2418:
2414:
2410:
2405:
2401:
2397:
2393:
2392:acne vulgaris
2389:
2385:
2384:acne vulgaris
2380:
2376:
2374:
2370:
2366:
2362:
2357:
2355:
2351:
2347:
2343:
2339:
2335:
2332:(TNF-α), and
2331:
2327:
2326:interleukin-6
2323:
2322:interleukin-1
2309:
2302:
2298:
2295:
2292:
2289:
2288:
2287:
2279:
2271:
2269:
2265:
2261:
2257:
2251:
2248:
2243:
2240:
2236:
2235:Lloyd Conover
2231:
2227:
2223:
2219:
2215:
2211:
2196:
2193:
2190:
2188:
2187:Diethyl ether
2185:
2184:
2180:
2177:
2175:very slightly
2174:
2172:
2169:
2168:
2165:
2162:
2159:
2156:
2153:
2152:
2149:
2146:
2143:
2141:Aqueous acids
2140:
2139:
2135:
2133:very slightly
2132:
2130:very slightly
2129:
2126:
2125:
2121:
2119:very slightly
2118:
2116:very slightly
2115:
2112:
2111:
2107:
2104:
2101:
2099:Solubility in
2098:
2097:
2094:
2089:
2087:
2084:
2081:
2063:
2058:
2050:
2039:
2035:
2031:
2027:
2023:
2019:
2009:
2007:
2003:
1993:
1991:
1990:liver disease
1987:
1983:
1979:
1975:
1970:
1968:
1964:
1960:
1956:
1955:aqueous humor
1952:
1948:
1944:
1940:
1936:
1926:
1923:
1913:
1911:
1907:
1901:
1899:
1893:
1883:
1880:
1876:
1866:
1864:
1860:
1856:
1851:
1848:
1845:
1840:
1839:
1836:
1833:
1832:
1827:
1823:
1813:
1811:
1807:
1803:
1799:
1795:
1785:
1783:
1779:
1775:
1771:
1770:liver disease
1761:
1757:
1755:
1750:
1742:
1740:
1736:
1729:Off-label use
1726:
1724:
1720:
1716:
1712:
1711:sclerotherapy
1705:Sclerotherapy
1699:
1695:
1694:
1690:
1687:
1683:
1682:
1678:
1675:
1671:
1670:
1666:
1665:
1664:
1662:
1658:
1657:
1653:
1649:
1648:Streptococcus
1645:
1634:
1632:
1631:microfilariae
1628:
1627:elephantiasis
1624:
1620:
1617:
1614:
1610:
1609:
1605:
1595:
1593:
1592:
1591:P. falciparum
1587:
1582:
1580:
1579:P. falciparum
1576:
1575:P. falciparum
1572:
1571:P. falciparum
1568:
1564:
1559:
1557:
1553:
1552:P. falciparum
1549:
1548:
1537:
1535:
1531:
1527:
1517:
1515:
1510:
1508:
1497:
1495:
1490:
1488:
1483:
1480:
1479:meta-analysis
1476:
1475:periodontitis
1471:
1469:
1456:
1455:
1450:
1447:
1446:
1441:
1440:actinomycosis
1438:
1435:
1433:
1432:Fusobacterium
1428:
1425:
1422:
1421:
1416:
1413:
1410:
1409:
1404:
1401:
1398:
1397:
1392:
1389:
1388:
1387:
1376:
1375:
1370:
1367:
1364:
1363:
1357:
1356:
1351:
1348:
1344:
1343:
1338:
1337:
1336:
1334:
1330:
1329:
1324:
1320:
1319:
1314:
1313:
1308:
1295:
1294:
1289:
1285:
1282:
1281:
1276:
1273:
1270:
1266:
1262:
1261:
1260:Acinetobacter
1257:
1254:
1253:
1249:
1247:) infections,
1246:
1242:
1241:
1237:
1234:
1233:
1229:
1228:
1227:
1225:
1212:
1209:
1206:
1205:
1200:
1197:
1194:
1193:bartonellosis
1191:
1188:
1184:
1183:
1178:
1175:
1172:
1171:
1167:
1164:
1161:
1158:
1155:
1152:
1151:
1146:
1143:
1142:
1137:
1134:
1131:
1130:
1125:
1122:
1119:
1118:
1113:
1110:
1107:
1104:
1101:
1100:
1095:
1091:
1087:
1084:
1081:
1080:
1075:
1072:
1071:
1066:
1062:
1058:
1054:
1050:
1047:
1046:
1045:
1042:
1040:
1036:
1032:
1028:
1024:
1023:
1018:
1017:
1012:
1011:
1006:
1005:
1000:
999:
994:
993:
988:
987:
982:
981:
968:Antibacterial
965:
963:
959:
955:
951:
946:
943:
939:
935:
931:
927:
923:
919:
915:
906:
898:
889:
883:
879:
874:
872:
868:
864:
860:
855:
853:
849:
845:
841:
837:
833:
829:
825:
821:
817:
813:
809:
805:
801:
798:
794:
784:
777:
771:
762:
757:
756:
753:
746:
737:
736:
733:
726:
719:
715:
714:
712:
709:
704:
697:
695:
691:
664:
662:
658:
653:
649:
645:
642:
640:
638:ECHA InfoCard
634:
626:
622:
621:DTXSID0037653
618:
617:
615:
606:
602:
595:
591:
590:
588:
586:
582:
575:
571:
570:
568:
566:
562:
555:
551:
550:
548:
546:
542:
535:
531:
530:
528:
526:
522:
515:
511:
510:
508:
506:
502:
495:
491:
490:
488:
486:
482:
475:
471:
470:
468:
461:
457:
450:
446:
445:
443:
441:
437:
429:
425:
421:
417:
413:
409:
404:
403:
400:
393:
388:
384:
382:
378:
374:
372:
365:
361:
359:
355:
351:
349:
345:
341:
339:
335:
331:
327:
321:
311:
308:
298:
295:
285:
284:
282:
280:
276:
271:
263:
258:
253:
248:
245:
244:
242:
240:
236:
233:
229:
226:
224:
218:
212:
203:
202:
200:
198:
192:
185:
180:
171:
170:
168:
166:
162:
158:
154:
152:
148:
144:
140:
138:
134:
130:
126:
124:
120:
116:
115:
101:
54:
52:Pronunciation
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
10914:tetracycline
10807:/piperaquine
10763:pyronaridine
10747:
10743:tetracycline
10643:Sulfonamides
10618:
10576:halofantrine
10567:+ artemether
10562:lumefantrine
10439:Aconoidasida
10415:sulfadiazine
10384:Isosporiasis
10373:nitazoxanide
10366:
10205:
10202:tetracycline
10192:oxyquinoline
10112:Furazolidone
10102:Nitazoxanide
9976:
9934:Benznidazole
9911:Fexinidazole
9880:Tryparsamide
9862:Eflornithine
9814:directed at
9704:Quinupristin
9700:Dalfopristin
9628:Lincosamides
9565:Tildipirosin
9535:Oleandomycin
9500:Erythromycin
9470:Azithromycin
9306:Tetracycline
9281:Omadacycline
9266:Meclocycline
9256:Eravacycline
9246:Clomocycline
9235:
9161:Micronomicin
9134:
9109:Hygromycin B
9098:+loteprednol
9056:Ribostamycin
9029:Streptomycin
9019:Streptomyces
9017:
8839:Tetracycline
8824:Oxyquinoline
8773:
8759:Clotrimazole
8610:
8606:
8600:
8567:
8563:
8519:
8515:
8505:
8470:
8467:Cell Reports
8466:
8456:
8429:
8425:
8375:
8371:
8361:
8326:
8322:
8312:
8277:
8273:
8263:
8228:
8224:
8214:
8202:. Retrieved
8185:
8174:
8141:
8137:
8130:
8093:
8089:
8079:
8046:
8042:
8036:
8001:
7997:
7987:
7952:
7949:Neurotox Res
7948:
7938:
7903:
7899:
7889:
7854:
7850:
7840:
7803:
7799:
7789:
7754:
7750:
7740:
7706:(12): 7246.
7703:
7699:
7689:
7656:
7652:
7646:
7612:(18): 2244.
7609:
7605:
7595:
7560:
7557:Inflammation
7556:
7546:
7521:
7517:
7511:
7481:(2): 78–81.
7478:
7474:
7468:
7441:
7437:
7427:
7395:(3): 178–9.
7392:
7388:
7378:
7333:
7329:
7319:
7284:
7280:
7270:
7235:
7231:
7221:
7196:
7192:
7186:
7161:
7157:
7110:
7106:
7096:
7071:
7067:
7061:
7047:(3): 156–9.
7044:
7040:
7034:
7010:(9): 26–32.
7007:
7003:
6993:
6960:
6956:
6950:
6905:
6901:
6891:
6858:
6854:
6847:
6820:
6816:
6806:
6771:
6767:
6709:
6705:
6695:
6660:
6656:
6646:
6619:
6613:
6591:(1): 27–34.
6588:
6584:
6578:
6545:
6541:
6535:
6523:. Retrieved
6490:
6486:
6476:
6454:(6): 610–3.
6451:
6447:
6441:
6408:
6404:
6398:
6386:. Retrieved
6382:the original
6377:
6368:
6356:. Retrieved
6347:
6338:
6326:. Retrieved
6312:
6304:the original
6299:
6289:
6281:the original
6274:
6264:
6256:the original
6249:
6240:
6232:the original
6227:
6218:
6210:the original
6205:
6196:
6188:the original
6183:
6174:
6166:the original
6161:
6152:
6144:the original
6139:
6119:the original
6114:
6105:
6096:
6068:
6051:the original
6024:
6015:
6006:
6000:
5989:Doxycycline
5963:
5936:. Retrieved
5927:
5918:
5891:
5887:
5877:
5842:
5838:
5806:
5800:
5765:
5761:
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5730:
5726:
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5683:
5677:
5644:
5640:
5633:
5619:(6): 391–9.
5616:
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5561:
5557:
5547:
5510:
5506:
5496:
5471:
5467:
5461:
5444:
5440:
5412:
5366:
5362:
5352:
5340:. Retrieved
5331:
5322:
5289:
5285:
5279:
5246:
5242:
5236:
5224:. Retrieved
5220:the original
5205:
5196:
5156:
5152:
5142:
5115:
5109:
5097:. Retrieved
5085:
5033:
5029:
5022:
4992:(4): 211–6.
4989:
4985:
4978:
4959:
4954:
4917:
4913:
4903:
4886:
4882:
4876:
4841:
4837:
4827:
4815:. Retrieved
4806:
4797:
4785:. Retrieved
4776:
4767:
4755:. Retrieved
4728:
4724:
4714:
4702:. Retrieved
4693:
4683:
4671:. Retrieved
4662:
4653:
4641:. Retrieved
4632:
4623:
4596:
4592:
4582:
4547:
4543:
4533:
4521:. Retrieved
4512:
4502:
4465:
4461:
4451:
4439:. Retrieved
4397:
4393:
4346:
4342:
4332:
4297:
4293:
4283:
4258:
4254:
4247:
4212:
4208:
4198:
4168:(3): 330–4.
4165:
4161:
4155:
4130:
4126:
4119:
4090:
4086:
4080:
4062:
4037:
4033:
4026:
4014:. Retrieved
4000:
3988:. Retrieved
3965:
3953:. Retrieved
3926:
3922:
3912:
3891:
3887:
3877:
3840:
3836:
3826:
3815:the original
3810:
3724:the original
3719:
3609:
3605:
3599:
3582:
3578:
3572:
3539:
3535:
3529:
3505:(2): 79–84.
3502:
3498:
3488:
3456:(3): 661–7.
3453:
3449:
3439:
3406:
3402:
3396:
3384:. Retrieved
3375:
3365:
3353:. Retrieved
3346:the original
3333:
3320:
3316:
3306:
3281:
3277:
3241:
3237:
3231:
3209:(1): 49–54.
3206:
3202:
3196:
3163:
3159:
3153:
3128:
3124:
3069:(2): 137–9.
3066:
3062:
3056:
3031:
3027:
3020:
3008:. Retrieved
3004:
2995:
2983:. Retrieved
2974:
2965:
2945:
2927:10665/325771
2918:
2909:
2897:. Retrieved
2877:
2870:
2850:
2843:
2823:
2816:
2781:
2777:
2774:"Apicoplast"
2767:
2729:(1): 17–32.
2726:
2722:
2699:. Retrieved
2685:
2673:. Retrieved
2664:
2655:
2643:. Retrieved
2582:to regulate
2568:mitochondria
2559:
2555:
2545:
2538:accessible.
2536:
2532:
2507:
2485:, including
2471:dopaminergic
2456:
2429:
2398:, including
2381:
2377:
2358:
2319:
2285:
2277:
2252:
2244:
2239:tetracycline
2207:
2015:
1999:
1972:Doxycycline
1971:
1939:blood plasma
1932:
1919:
1902:
1895:
1886:Pharmacology
1872:
1869:Interactions
1852:
1849:
1844:erythematous
1841:
1837:
1829:
1822:tetracycline
1819:
1798:class D drug
1791:
1774:isotretinoin
1767:
1758:
1751:
1748:
1732:
1708:
1697:
1691:
1685:
1679:
1673:
1672:: 0.03
1667:
1642:
1640:
1606:
1601:
1589:
1583:
1578:
1574:
1570:
1560:
1551:
1545:
1543:
1540:Antimalarial
1536:(rifampin).
1530:streptomycin
1523:
1511:
1503:
1491:
1484:
1472:
1465:
1452:
1443:
1430:
1418:
1406:
1394:
1385:
1372:
1361:
1358:, including
1353:
1346:
1340:
1327:
1316:
1310:
1304:
1291:
1278:
1268:
1267:species and
1264:
1258:
1250:
1244:
1238:
1230:
1221:
1211:Lyme disease
1202:
1187:streptomycin
1180:
1168:
1148:
1139:
1127:
1115:
1097:
1077:
1068:
1057:scrub typhus
1043:
1035:ehrlichiosis
1031:Lyme disease
1020:
1014:
1008:
1002:
996:
990:
984:
978:
976:
947:
918:Lyme disease
911:
892:Medical uses
875:
856:
828:Lyme disease
810:and certain
792:
791:
780:
774:
427:
423:
419:
415:
411:
407:
368:Elimination
279:Legal status
273:Legal status
165:License data
18:
10963:from market
10882:clindamycin
10768:piperaquine
10753:clindamycin
10748:doxycycline
10737:+ proguanil
10702:artemisinin
10651:sulfadoxine
10612:cycloguanil
10590:Antifolates
10520:tafenoquine
10494:chloroquine
10489:amodiaquine
10456:Individual
10420:clindamycin
10368:thiazolides
10343:Conoidasida
10242:from market
10216:Paromomycin
10206:Doxycycline
10183:Secnidazole
10147:Carnidazole
10090:Albendazole
10017:Paromomycin
10007:Miltefosine
9997:Pentamidine
9993:benzamidine
9890:Pentamidine
9886:benzamidine
9876:Melarsoprol
9754:from market
9690:Linopristin
9636:Clindamycin
9613:Cethromycin
9540:Rokitamycin
9525:Midecamycin
9520:Kitasamycin
9437:Florfenicol
9414:Amphenicols
9358:inhibitors)
9324:Tigecycline
9301:Sarecycline
9276:Minocycline
9271:Metacycline
9261:Lymecycline
9236:Doxycycline
9080:Bekanamycin
9051:Paromomycin
9009:inhibitors)
8914:Epinephrine
8909:Benzydamine
8904:Becaplermin
8829:Polynoxylin
8809:Minocycline
8794:Mepartricin
8774:Doxycycline
8731:antiseptics
8689:prophylaxis
8613:(1): 8–13.
7287:(3): e082.
7164:: 733–745.
6908:: 355–420.
6817:J Vasc Surg
6657:Tumour Biol
5507:Antibiotics
5474:: 212–215.
5292:(1): 7–18.
3929:(2): 1–44.
3612:(1): 73–4.
3376:Yellow Book
3323:(10): 503.
3278:Drugs Aging
2899:9 September
2525:treatment.
2512:, the UK's
2459:antioxidant
2301:minocycline
2299:instead of
2102:Doxycycline
2018:monohydrate
1967:minocycline
1951:gallbladder
1947:body fluids
1826:esophagitis
1810:rickettsial
1723:lymphoceles
1526:brucellosis
1454:Clostridium
1415:listeriosis
1365:infections,
1318:S. faecalis
1235:infections,
1177:brucellosis
1173:infections,
1106:psittacosis
1004:Haemophilus
942:rickettsial
922:prostatitis
793:Doxycycline
701: g·mol
644:100.008.429
574:CHEBI:60648
474:Doxycycline
390:Identifiers
375:10–22 hours
232:intravenous
184:Doxycycline
151:MedlinePlus
123:Trade names
23:Doxycycline
11016:Categories
10874:Babesiosis
10805:arterolane
10733:atovaquone
10712:artesunate
10697:artemether
10620:biguanides
10536:mefloquine
10510:primaquine
10468:inhibitors
10425:atovaquone
10196:Iodoquinol
10155:Tinidazole
10124:Quinacrine
10108:nitrofuran
10098:thiazolide
10080:Tinidazole
10064:Giardiasis
9944:Nifurtimox
9940:nitrofuran
9686:Flopristin
9646:Pirlimycin
9641:Lincomycin
9590:Tylvalosin
9570:Tilmicosin
9555:Spiramycin
9530:Miocamycin
9485:Carrimycin
9480:Carbomycin
9462:Macrolides
9385:Ranbezolid
9365:Eperezolid
9356:initiation
9185:Astromicin
9180:Verdamicin
9171:Isepamicin
9166:Plazomicin
9151:Netilmicin
9146:Gentamicin
9094:Tobramycin
9046:Framycetin
9007:initiation
8918:Adrenalone
8804:Miconazole
8784:Hexetidine
8432:: 106636.
8144:: 114187.
8096:(1): 536.
7806:: 739186.
7757:: 107462.
7475:Compr Ther
6525:2 February
6115:Justia Law
5938:23 January
5369:(1): 148.
5342:9 December
5086:toku-e.com
4817:4 December
4593:Med J Aust
4468:(1): 376.
4441:5 February
4016:5 February
3990:5 February
3955:5 February
3843:(1): 884.
2701:4 December
2675:4 December
2602:References
2522:SARS-CoV-2
2499:depression
2373:matrilysin
2210:penicillin
2171:Chloroform
2136:sparingly
2093:Solubility
2083:methanolic
1974:metabolism
1890:See also:
1802:breastmilk
1656:Mycoplasma
1652:Ureaplasma
1563:apicoplast
1534:rifampicin
1442:caused by
1429:caused by
1405:caused by
1393:caused by
1377:infection.
1371:caused by
1345:(formerly
1293:Klebsiella
1290:caused by
1277:caused by
1243:(formerly
1204:Klebsiella
1179:caused by
1138:caused by
1114:caused by
1070:Rickettsia
920:, chronic
871:apicoplast
800:antibiotic
706:3D model (
694:Molar mass
594:ChEMBL1433
534:334895S862
505:ChemSpider
440:CAS Number
399:IUPAC name
362:Negligible
358:Metabolism
10973:Phase III
10961:Withdrawn
10758:mepacrine
10707:artemotil
10656:sulfalene
10631:proguanil
10546:quinidine
10515:pamaquine
10252:Phase III
10240:Withdrawn
10212:neomycin
10055:Trichozoa
9868:arsenical
9858:ornithine
9819:parasites
9764:Phase III
9752:Withdrawn
9600:Ketolides
9515:Josamycin
9475:Boromycin
9395:Tedizolid
9390:Sutezolid
9380:Radezolid
9375:Posizolid
9370:Linezolid
9201:Butirosin
9156:Sisomicin
9119:Apramycin
9114:Totomycin
9085:Dibekacin
9075:Arbekacin
9065:Kanamycin
8894:Amlexanox
8814:Natamycin
8727:Infection
8697:Dectaflur
8166:253300844
8071:257218181
7781:231988574
7681:263151406
7370:261786019
7262:218635190
6985:244490539
6712:: 32659.
6687:206614670
6515:231881758
6378:drugs.com
6047:0250-863X
5770:CiteSeerX
5134:853455295
4757:23 August
3980:1556-3332
3634:218880245
3536:Neurology
3010:30 August
2985:30 August
2661:"Malaria"
2645:18 August
2584:transgene
2338:cytokines
2191:insoluble
2051:α
1996:Chemistry
1778:retinoids
1776:or other
1644:Chlamydia
1619:nematodes
1613:parasitic
1608:Wolbachia
1604:symbiotic
1567:organelle
1494:chancroid
1434:fusiforme
1207:species),
1157:tularemia
1136:chancroid
962:gonorrhea
956:and with
950:chlamydia
932:, severe
926:sinusitis
812:parasites
381:Excretion
370:half-life
221:Routes of
195:Pregnancy
143:Monograph
137:Drugs.com
11006:Medicine
10928:Stramen-
10689:lactones
10466:Hemozoin
10013:neomycin
9816:excavata
9222:binding)
9133:-micin (
9070:Amikacin
9041:Neomycin
9016:-mycin (
8819:Neomycin
8627:11438047
8546:26475870
8497:25772356
8448:38185273
8404:34584416
8353:35227056
8304:35462191
8255:34329624
8198:Archived
8158:36343696
8122:34711196
8063:36843128
8028:31879858
7979:71147889
7971:30798507
7930:36869773
7921:10318877
7881:35294307
7832:34899697
7773:33611055
7732:35742496
7673:37751595
7638:37759467
7629:10526833
7587:31955291
7538:12900822
7503:28262106
7495:18004018
7460:26897386
7419:45726787
7362:37820334
7353:10951614
7311:37521754
7302:10378739
7254:32401726
7213:14673277
7178:34161892
7137:36407641
7088:27538054
7053:16146617
7026:33133338
6977:34812859
6942:28662828
6883:23253029
6875:15665254
6839:14681644
6798:36759188
6744:27619752
6679:29034777
6605:17315050
6570:37723341
6562:28516469
6519:Archived
6507:33568043
6468:21723947
6433:26680094
6425:23971874
6388:29 April
6352:Archived
6322:Archived
5932:Archived
5910:16816396
5869:23966509
5792:12436822
5747:12063491
5712:20085592
5704:20700115
5661:23656210
5625:15564203
5588:21460003
5539:27025622
5488:28286288
5395:28407772
5336:Archived
5314:25492353
5306:20814687
5263:12431134
5175:31912620
5099:16 April
5090:Archived
5058:21382828
5050:15964448
5014:23349595
5006:12684759
4946:26555664
4868:16940111
4811:Archived
4781:Archived
4777:DailyMed
4751:Archived
4747:22296864
4704:10 March
4698:Archived
4673:10 March
4667:Archived
4643:10 March
4637:Archived
4615:38479437
4574:38118022
4565:10805625
4523:10 March
4517:Archived
4494:38575877
4485:10996150
4435:Archived
4414:38361192
4373:25597924
4324:25919144
4275:21417590
4239:22895927
4190:28700961
4182:24721547
4147:38493509
4111:38167816
4072:Archived
4054:22972867
4010:Archived
3984:Archived
3949:Archived
3945:27172113
3904:Archived
3900:23535757
3869:38110855
3860:10726538
3626:11234985
3564:38661885
3521:11450675
3431:23358315
3386:16 April
3380:Archived
3325:Archived
3298:38649625
3258:19061755
3188:20540747
3180:16411105
3145:58790579
3091:28328073
3005:ClinCalc
2979:Archived
2975:ClinCalc
2917:(2019).
2893:Archived
2808:24698369
2759:34647314
2751:22191524
2695:Archived
2669:Archived
2639:Archived
2572:confound
2556:in vitro
2552:reagents
2479:synaptic
2340:such as
2328:(IL-6),
2324:(IL-1),
2282:Research
2006:azotemia
1978:chelates
1963:meninges
1616:filarial
1457:species.
1391:syphilis
1328:P. acnes
1296:species.
1269:Herellea
1252:Shigella
1182:Brucella
1090:trachoma
958:cefixime
859:diarrhea
848:by mouth
840:syphilis
808:bacteria
783:(verify)
514:10482106
485:DrugBank
449:564-25-0
239:ATC code
228:By mouth
197:category
179:DailyMed
10783:nations
10541:quinine
10448:Malaria
10332:Apicom-
10036:polyene
9967:polyene
9900:Suramin
9585:Tylosin
8779:Eugenol
8702:Olaflur
8592:7792603
8572:Bibcode
8564:Science
8537:4631686
8488:4565776
8395:8464303
8344:8892560
8295:8964533
8246:8315758
8113:8554858
8019:7118056
7872:9115781
7823:8662812
7723:9224192
7578:7224120
7411:1357852
7193:Skinmed
7128:9672876
7017:7577330
6933:5548434
6789:9961363
6735:5020643
6714:Bibcode
6706:Sci Rep
6358:31 July
6328:31 July
6251:WSMV-TV
5860:3889732
5669:9418654
5579:3062442
5530:4790331
5453:3055652
5386:5390373
5271:8595370
5226:16 July
4937:4641395
4920:: 445.
4914:Malar J
4859:1563505
4787:5 March
4694:Aidsmap
4513:Aidsmap
4364:4486007
4315:6481562
4230:7017847
3591:8900357
3556:8035916
3480:7793869
3423:1637021
3223:9006372
3048:3162653
2786:Bibcode
2731:Bibcode
2560:in vivo
2396:rosacea
2388:rosacea
2350:neurons
2264:Actavis
2204:History
2127:Ethanol
2122:freely
2030:aqueous
2028:, a 1%
2026:ethanol
2022:hyclate
1877:due to
1835:colitis
1768:Severe
1556:malaria
1417:due to
1369:anthrax
1163:cholera
1126:due to
1061:Q fever
938:rosacea
863:sunburn
844:malaria
832:cholera
802:of the
699:444.440
661:Formula
494:DB00254
460:PubChem
259: (
257:A01AB22
255:)
249: (
247:J01AA02
210: D
181::
157:a682063
10992:Portal
10956:WHO-EM
10900:Cilio-
10819:(ASMQ)
10813:(ASAQ)
10781:Combi-
10458:agents
10321:Alveo-
10235:WHO-EM
9872:Atoxyl
9747:WHO-EM
9682:NXL103
8984:QJ01XQ
8686:Caries
8625:
8590:
8544:
8534:
8495:
8485:
8446:
8402:
8392:
8351:
8341:
8302:
8292:
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8243:
8204:1 June
8164:
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8110:
8069:
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6983:
6975:
6940:
6930:
6920:
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6873:
6837:
6796:
6786:
6768:eNeuro
6742:
6732:
6685:
6677:
6634:
6603:
6568:
6560:
6513:
6505:
6466:
6431:
6423:
6348:GoodRx
6075:
6045:
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5048:
5030:Lancet
5012:
5004:
4966:
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3083:345730
3081:
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2885:
2858:
2831:
2806:
2757:
2749:
2475:axonal
2450:, and
2266:, and
2208:After
2163:freely
2160:freely
2155:Alkali
2147:freely
2144:freely
1984:. The
1910:faeces
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