443:
420:
506:
36:
608:, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.
1640:
548:
InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
1064:
1663:
1092:
2275:
2270:
4156:
903:
878:. In healthy people, 60% are eliminated via the kidneys and 40% via the faeces. In people with impaired kidney function, elimination via the faeces is increased. The
4388:
3728:
1468:
Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Claeson P (June 2001). "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells".
2207:
902:
was able to obtain a pure sample in 1875. The modern therapeutic use of this molecule was made possible by the works of the pharmacist and the French chemist
76:
1505:
Hippius M, Humaid B, Sicker T, Hoffmann A, Göttler M, Hasford J (August 2001). "Adverse drug reaction monitoring--digitoxin overdosage in the elderly".
564:
4303:
616:
Digitoxin is used for the treatment of heart failure, especially in people with impaired kidney function. It is also used to treat certain kinds of
4069:
1157:
Kurowski V, Iven H, Djonlagic H (1992). "Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies".
2260:
4120:
4112:
3695:
949:
4455:
4450:
3948:
3943:
3938:
3808:
4414:
4334:
4131:
3433:
3217:
1925:
520:
2920:
4206:
4201:
3973:
3898:
1047:
neoglycosides which displayed improved anticancer potency and reduced inotropic activity (the perceived mechanism of general toxicity).
4181:
4176:
4023:
4018:
2370:
2200:
4516:
4349:
4344:
4028:
3863:
3818:
3167:
1767:
1762:
1757:
1752:
4186:
4094:
4089:
4079:
3993:
3918:
2930:
4033:
3709:
4511:
2193:
2151:
1289:
1115:
4506:
3002:
2480:
1694:
1581:"Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells"
4240:
2465:
2460:
4552:
2513:
571:
540:
1734:
1729:
1724:
1719:
2529:
2168:
1918:
1657:
3084:
2650:
1651:
Comparing the
Toxicity of Digoxin and Digitoxin in a Geriatric Population: Should an Old Drug Be Rediscovered? on
3664:
910:
in 1925, but the full structure with an exact determination of the sugar groups was not accomplished until 1962.
195:
106:
2724:
2692:
2915:
956:
268:
1223:
An
Account of the Foxglove and Some of its Medical Uses: With Practical Remarks on Dropsy and other Diseases
4501:
2815:
438:
319:
4265:
2375:
2350:
4521:
2763:
1911:
1002:
907:
821:
399:
388:
2768:
1644:
875:
777:
3823:
3733:
2955:
859:
854:
The drug is almost completely absorbed from the gut. When in the bloodstream, 90 to 97% are bound to
4384:
4146:
4059:
3684:
3377:
2910:
2905:
2805:
1687:
918:
649:
415:
704:, the specific treatment for digoxin poisoning, are also effective in serious digitoxin toxicity.
3672:
3582:
3207:
3197:
3132:
2660:
2430:
2156:
827:
641:
58:
48:
2470:
2445:
2385:
2380:
1305:
Menger L, Vacchelli E, Kepp O, Eggermont A, Tartour E, Zitvogel L, et al. (February 2013).
970:
3640:
3192:
2672:
2597:
2592:
2545:
938:
653:
140:
2400:
1865:
1279:
921:, a Belgian serial killer, was sentenced to death for poisoning eleven people with digitoxin.
368:
4542:
3913:
3738:
3676:
3202:
2746:
2709:
2697:
2565:
660:
259:
69:
2475:
2450:
2425:
2410:
2345:
2285:
2280:
308:
3333:
2990:
2729:
2635:
2577:
2355:
1850:
1592:
1418:
964:
879:
328:
164:
2415:
2290:
2265:
1875:
1828:
1146:(in German). Vienna: Österreichischer Apothekerverlag. Digimerck 0,07 mg - Tabletten.
8:
4394:
4309:
3373:
3157:
3014:
2980:
2790:
2490:
1870:
1860:
1680:
1579:
Srivastava M, Eidelman O, Zhang J, Paweletz C, Caohuy H, Yang Q, et al. (May 2004).
1080:
1015:
899:
621:
214:
65:
2405:
1596:
1422:
1027:
Digitoxin and related cardenolides display anticancer activity against a range of human
442:
419:
223:
4547:
4476:
4260:
4141:
3723:
3337:
2997:
2655:
2572:
2517:
2360:
2320:
2310:
2250:
2219:
1493:
1441:
1406:
1382:
1355:
1331:
1306:
1255:
1238:
1182:
1040:
895:
601:
4064:
2340:
1615:
1580:
4074:
3848:
3297:
2305:
2300:
2227:
2216:
1934:
1887:
1833:
1620:
1567:
1562:
1535:
1522:
1485:
1481:
1446:
1387:
1336:
1285:
1260:
1174:
1111:
1084:
1036:
794:
701:
645:
585:
2455:
1892:
1497:
1407:"Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization"
4324:
3793:
2758:
2505:
2390:
2330:
2325:
2315:
2295:
2255:
2110:
1610:
1600:
1557:
1547:
1514:
1477:
1436:
1426:
1377:
1367:
1326:
1318:
1250:
1186:
1166:
1076:
1010:
944:
749:
729:
617:
528:
O=C\1OC/C(=C/1)2CC8(O)2(C)CC78CC67(C)CC(O5O(C)(O4O((O3O((O)(O)C3)C)(O)C4)C)(O)C5)C6
455:
248:
122:
89:
2435:
1536:"Digitoxin medication and cancer; case control and internal dose-response studies"
3883:
3616:
3490:
3122:
3069:
3024:
2825:
2051:
2020:
1979:
1711:
933:
150:
130:
3594:
3590:
3568:
1938:
4354:
4116:
3988:
3417:
3137:
3109:
3101:
2940:
2845:
2835:
2780:
2775:
2677:
2495:
2395:
2185:
2162:
1997:
1585:
Proceedings of the
National Academy of Sciences of the United States of America
1411:
Proceedings of the
National Academy of Sciences of the United States of America
898:
dates back to 1775. For quite some time, the active compound was not isolated.
855:
782:
741:
724:
668:
1652:
830:
in heart muscle cells, resulting in increased force of contractions (positive
4536:
3968:
3803:
3778:
3558:
3476:
3309:
3287:
3142:
3019:
2751:
2602:
2560:
2056:
1947:
1855:
1838:
1044:
867:
804:
672:
589:
431:
1903:
1605:
1431:
4136:
4108:
4084:
3953:
3878:
3788:
3783:
3773:
3576:
3542:
3532:
3528:
3463:
3457:
3389:
2885:
2875:
2850:
2714:
2667:
2521:
2509:
2096:
2081:
2071:
2002:
1964:
1624:
1571:
1552:
1526:
1489:
1450:
1391:
1340:
1264:
1088:
1065:"Treatment of congestive heart failure--current status of use of digitoxin"
843:
839:
761:
745:
597:
84:
1405:
Langenhan JM, Peters NR, Guzei IA, Hoffmann FM, Thorson JS (August 2005).
1372:
1178:
27:
4481:
4409:
4374:
4369:
4329:
4299:
4285:
4275:
4270:
4099:
4043:
4038:
3933:
3928:
3908:
3858:
3833:
3828:
3753:
3743:
3660:
3656:
3652:
3644:
3634:
3630:
3598:
3586:
3572:
3564:
3504:
3437:
3381:
3353:
3187:
3162:
3034:
2935:
2810:
2734:
2704:
2555:
2535:
2485:
2439:
2335:
2086:
2076:
2034:
1974:
1843:
1800:
1790:
863:
835:
765:
697:
664:
637:
1221:
799:
substances that bind digitoxin in the gut, such as aluminium containing
288:
4424:
4404:
4379:
4226:
4171:
4126:
4104:
4013:
4008:
3978:
3963:
3958:
3923:
3813:
3768:
3748:
3626:
3620:
3524:
3512:
3472:
3453:
3429:
3413:
3323:
3319:
3293:
3279:
3232:
3227:
3222:
3212:
3182:
3152:
3147:
3127:
3064:
2985:
2965:
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2890:
2840:
2741:
2682:
2615:
2610:
2587:
2525:
2500:
2133:
1805:
1785:
1322:
1170:
790:
737:
593:
482:
299:
2925:
2420:
35:
4419:
4399:
4339:
4319:
4161:
3998:
3873:
3868:
3853:
3838:
3798:
3680:
3648:
3606:
3554:
3550:
3536:
3516:
3500:
3449:
3425:
3421:
3409:
3401:
3397:
3357:
3345:
3329:
3315:
3305:
3301:
3257:
3117:
3091:
3079:
3054:
3044:
3029:
3009:
2960:
2860:
2855:
2830:
2820:
2785:
2645:
2620:
2582:
2540:
2043:
2012:
1969:
1795:
1777:
1703:
1518:
831:
786:
234:
177:
2365:
4290:
4280:
3983:
3843:
3763:
3758:
3691:
3508:
3445:
3441:
3405:
3393:
3365:
3361:
3349:
3341:
3271:
3059:
3049:
2895:
2880:
2865:
2800:
2795:
2640:
2550:
2125:
1820:
1810:
1354:
Elbaz HA, Stueckle TA, Tse W, Rojanasakul Y, Dinu CZ (April 2012).
720:
689:
348:
279:
1019:
album, the narrator murders his daughter by feeding her foxglove.
886:
liver functions are impaired, in which case it is usually longer.
696:, vomiting, diarrhea, confusion, visual disturbances, and cardiac
505:
4445:
4191:
4003:
3903:
3893:
3888:
3668:
3612:
3602:
3494:
3369:
3177:
3172:
3074:
3039:
2970:
2870:
2719:
2687:
2625:
2115:
2104:
2066:
1882:
871:
800:
685:
605:
20:
4364:
4359:
4216:
3480:
3468:
3283:
3252:
3247:
3242:
2975:
2630:
1989:
1744:
1639:
1578:
1507:
International
Journal of Clinical Pharmacology and Therapeutics
1032:
1031:
cell lines in vitro but the clinical use of digitoxin to treat
1028:
733:
693:
379:
156:
3710:
1467:
772:
Drugs that can decrease the effectivity of digitoxin include:
4440:
4314:
4196:
4166:
3385:
3267:
3096:
1672:
1062:
719:
substances that lower potassium or magnesium levels, such as
496:
359:
1404:
1304:
404:
4460:
4241:
4151:
3520:
3275:
1956:
1504:
1353:
755:
339:
4295:
1356:"Digitoxin and its analogs as novel cancer therapeutics"
1200:
906:(1812–1889). The first structural analysis was done by
2611:
Epiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)
1533:
1156:
1307:"Trial watch: Cardiac glycosides and cancer therapy"
712:
Drugs that can increase digitoxin toxicity include:
929:Digitoxin is used as a poison or murder weapon in:
776:substances that increase potassium levels, such as
267:
834:), reduced speed of electric conduction (negative
1236:
1063:Belz GG, Breithaupt-Grögler K, Osowski U (2001).
4534:
2215:
842:), and reduced frequency of heartbeat (negative
247:
679:
636:problems with the heart rhythm, such as severe
222:
3715:Tooltip Selective estrogen receptor modulators
3070:Furostilbestrol (diethylstilbestrol difuroate)
2431:16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
1105:
2261:3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
2201:
1933:
1919:
1688:
1534:Haux J, Klepp O, Spigset O, Tretli S (2001).
2371:10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
960:, season 9, episode 19: "The Descent of Man"
822:Cardiac glycoside § Mechanism of action
684:Digitoxin exhibits similar toxic effects to
4246:Tooltip G protein-coupled estrogen receptor
3065:Fosfestrol (diethylstilbestrol diphosphate)
114:In general: ℞ (Prescription only)
3208:Triphenylmethylethylene (triphenylpropene)
2532:, many others; via estrogenic metabolites)
2456:17α-Epiestriol (16α-hydroxy-17α-estradiol)
2208:
2194:
1926:
1912:
1695:
1681:
1069:European Journal of Clinical Investigation
1005:, season 4, episode 18: “The Hardest Part”
441:
418:
307:
2228:
1614:
1604:
1561:
1551:
1440:
1430:
1381:
1371:
1330:
1254:
1219:
1141:
327:
1243:The Yale Journal of Biology and Medicine
1277:
1150:
866:in part by CYP3A4; metabolites include
414:
287:
53:Digalen, Digitaline, Digitmerck, others
4535:
1360:Experimental Hematology & Oncology
1237:Diefenbach WC, Meneely JK (May 1949).
815:
754:inhibitors of the transporter protein
432:
2189:
1907:
1676:
999:Several episodes of Murder She Wrote.
768:(slow heartbeat) caused by digitoxin.
387:
367:
1137:
1135:
1133:
1131:
1129:
1127:
1081:10.1046/j.1365-2362.2001.0310s2010.x
894:The first description of the use of
838:), increased excitability (positive
627:
88:
1110:(in German). Springer. p. 43.
1056:
849:
347:
238:
13:
1460:
1035:has been restricted by its narrow
913:
882:is 7 to 8 days except when kidney
14:
4564:
3607:taleranol (teranol, β-zearalanol)
2522:metandienone (methandrostenolone)
1633:
1124:
4517:Progesterone receptor modulators
4271:Afimoxifene (4-hydroxytamoxifen)
3153:Prinaberel (ERB-041, WAY-202041)
1638:
1482:10.1097/00001813-200106000-00009
466:
34:
4214:Coregulator-binding modulators:
2481:17β-Methyl-17α-dihydroequilenin
1398:
1347:
1226:. Classics of Medicine Library.
971:Calliphoridae and Country Roads
810:
707:
611:
553:Key:WDJUZGPOPHTGOT-XUDUSOBPSA-N
3045:Erteberel (SERBA-1, LY-500307)
1702:
1662:, a convenience link from the
1298:
1271:
1239:"Digitoxin; a critical review"
1230:
1213:
1193:
1099:
1043:led to the discovery of novel
1013:'s song, "The Rake's Song" on
740:; examples are the antibiotic
667:(low blood potassium levels),
644:(fast heartbeat caused by the
472:
460:
1:
4502:Receptor/signaling modulators
2466:17α-Ethynyl-3β-androstanediol
2461:17α-Ethynyl-3α-androstanediol
1050:
924:
652:, or first- to second-degree
205:14-hydroxycard-20(22)-enolide
182:60% via urine, 40% via faeces
4512:Androgen receptor modulators
2816:Lynestrenol phenylpropionate
1106:Erland Erdmann, ed. (2013).
990:, season 6, episode 5 (1977)
983:, season 9, episode 5 (1990)
736:, which slow down digitoxin
680:Adverse effects and toxicity
7:
4507:Estrogens and antiestrogens
4157:Oxabicycloheptene sulfonate
3844:Etacstil (GW-5638, DPC-974)
3020:Doisynoestrol (fenocycline)
2764:Ethinylestradiol 3-benzoate
2276:3β,5α-Dihydrolevonorgestrel
2271:3α,5α-Dihydrolevonorgestrel
1108:Therapie mit Herzglykosiden
1022:
996:: "College can be a Murder"
979:"Uneasy Lies the Crown" on
908:Adolf Otto Reinhold Windaus
785:of CYP3A4 or P-gp, such as
778:potassium sparing diuretics
10:
4569:
4224:Noncompetitive inhibitors:
3849:Ethamoxytriphetol (MER-25)
3010:Dimestrol (dianisylhexene)
2769:Ethinylestradiol sulfonate
889:
819:
632:Contraindications include
588:used for the treatment of
450:Chemical and physical data
18:
4494:
4469:
4433:
4266:7β-Hydroxyepiandrosterone
4253:
4239:
4052:
3824:Desmethylchlorotrianisene
3705:
3003:Diethylstilbestrol esters
2956:Bisdehydrodoisynolic acid
2376:11β-Chloromethylestradiol
2351:7β-Hydroxyepiandrosterone
2240:
2233:Tooltip Estrogen receptor
2226:
2146:
2124:
2095:
2042:
2033:
2011:
1988:
1955:
1946:
1819:
1776:
1743:
1710:
1281:Drug discovery: A history
1142:Haberfeld H, ed. (2021).
986:"Affair of the Heart" on
860:enterohepatic circulation
561:
536:
516:
494:
481:
454:
449:
430:
398:
378:
358:
338:
318:
298:
278:
258:
233:
213:
191:
186:
176:
163:
149:
139:
129:
121:
105:
100:
75:
57:
47:
42:
33:
4553:Drugs developed by Merck
4330:Fulvestrant (ICI-182780)
4147:Methylpiperidinopyrazole
4100:Fulvestrant (ICI-182780)
3583:Resorcylic acid lactones
2806:Hydroxyestrone diacetate
2742:Etamestrol (eptamestrol)
919:Marie Alexandrine Becker
904:Claude-Adolphe Nativelle
758:, such as clarithromycin
650:ventricular fibrillation
19:Not to be confused with
3641:Synthetic xenoestrogens
3198:Triphenylchloroethylene
3133:Methestrol dipropionate
2661:Polyestradiol phosphate
1866:Anthraquinone glycoside
1668:(subscription required)
1606:10.1073/pnas.0402030101
1432:10.1073/pnas.0503270102
1159:Intensive Care Medicine
828:sodium-potassium ATPase
826:Digitoxin inhibits the
642:ventricular tachycardia
3734:4'-Hydroxynorendoxifen
3729:2-Phenylbenzothiophene
3603:zeranol (α-zearalanol)
3306:phlorizin (phloridzin)
3193:Triphenylbromoethylene
3092:ICI-85966 (Stilbostat)
2673:Estramustine phosphate
2546:Bolandiol dipropionate
1553:10.1186/1471-2407-1-11
1284:. Wiley. p. 107.
976:"Casino Royale" (2006)
968:season 2, episode 20:
939:Appointment with Death
858:. Digitoxin undergoes
661:electrolyte imbalances
654:atrioventricular block
3914:Miproxifene phosphate
3739:27-Hydroxycholesterol
3203:Triphenyliodoethylene
2747:Ethinylandrostenediol
2710:Estrogenic substances
2698:Polyestriol phosphate
2566:Cloxestradiol acetate
1658:registration required
1647:at Wikimedia Commons
1373:10.1186/2162-3619-1-4
671:(low magnesium), and
592:and certain kinds of
70:Intravenous injection
3228:WAY-204688 (SIM-688)
3040:ERB-196 (WAY-202196)
2991:Dienestrol diacetate
2730:Estrone methyl ether
2636:Esterified estrogens
2578:Conjugated estrogens
2471:17β-Dihydroequilenin
2446:17α-Dihydroequilenin
2386:15α-Hydroxyestradiol
2381:11β-Methoxyestradiol
2356:8,9-Dehydroestradiol
1851:Cyanogenic glycoside
1220:Withering W (1785).
880:biological half-life
732:of the liver enzyme
4395:Propylpyrazoletriol
4310:Diarylpropionitrile
3158:Propylpyrazoletriol
3015:Dimethylstilbestrol
2981:Diarylpropionitrile
2791:Etynodiol diacetate
2491:Abiraterone acetate
2401:16α-Fluoroestradiol
1876:Flavonoid glycoside
1829:Alcoholic glycoside
1597:2004PNAS..101.7693S
1423:2005PNAS..10212305L
1016:The Hazards of Love
900:Oswald Schmiedeberg
816:Mechanism of action
622:atrial fibrillation
30:
4477:Diethylstilbestrol
4261:2-Methoxyestradiol
4192:TAS-108 (SR-16234)
4142:Methylepitiostanol
4080:EM-800 (SCH-57050)
4004:TAS-108 (SR-16234)
3724:2-Phenylbenzofuran
3338:8-prenylnaringenin
2998:Diethylstilbestrol
2656:Lipoidal estradiol
2631:ERA-63 (ORG-37663)
2573:Conjugated estriol
2518:methyltestosterone
2476:17β-Dihydroequilin
2451:17α-Dihydroequilin
2426:16β-Hydroxyestrone
2411:16α-Hydroxyestrone
2361:8,9-Dehydroestrone
2346:7α-Methylestradiol
2321:4-Methoxyestradiol
2311:4-Hydroxyestradiol
2286:3β-Hydroxytibolone
2281:3α-Hydroxytibolone
2251:2-Hydroxyestradiol
2173:Never to phase III
1935:Cardiac glycosides
1871:Coumarin glycoside
1861:Phenolic glycoside
1323:10.4161/onci.23082
1278:Sneader W (2005).
1201:"mediQ: Digitoxin"
1171:10.1007/BF01694351
1041:glycorandomization
702:antibody fragments
640:(slow heartbeat),
600:and is similar in
26:
4530:
4529:
4522:List of estrogens
4490:
4489:
4235:
4234:
4075:Cytestrol acetate
3298:isoliquiritigenin
3240:Unknown/unsorted:
2926:β-LGND2 (GTx-878)
2506:Anabolic steroids
2416:16α-Iodoestradiol
2306:4-Fluoroestradiol
2301:4-Androstenedione
2291:3β-Androstanediol
2266:3α-Androstanediol
2217:Estrogen receptor
2183:
2182:
2142:
2141:
2029:
2028:
1901:
1900:
1888:Steviol glycoside
1834:Cardiac glycoside
1735:C-glycosidic bond
1730:S-glycosidic bond
1725:N-glycosidic bond
1720:O-glycosidic bond
1643:Media related to
1470:Anti-Cancer Drugs
1291:978-0-471-89980-8
1117:978-3-642-69046-4
1075:(Suppl 2): 10–7.
1037:therapeutic index
988:McMillan and Wife
744:, the antifungal
628:Contraindications
586:cardiac glycoside
579:
578:
507:Interactive image
400:CompTox Dashboard
16:Chemical compound
4560:
4389:2,2',5'-PCB-4-OH
4325:Ethinylestradiol
4251:
4250:
4247:
4243:
3984:Rimostil (P-081)
3794:Chlorotrianisene
3716:
3712:
3491:Metalloestrogens
3270:-related (e.g.,
3085:Hexestrol esters
2759:Ethinylestradiol
2651:Estradiol esters
2406:16α-Hydroxy-DHEA
2391:16-Ketoestradiol
2331:5-Androstenediol
2326:4-Methoxyestrone
2316:4-Hydroxyestrone
2296:4-Androstenediol
2256:2-Hydroxyestrone
2238:
2237:
2234:
2230:
2210:
2203:
2196:
2187:
2186:
2107:(g-Strophanthin)
2040:
2039:
1953:
1952:
1928:
1921:
1914:
1905:
1904:
1697:
1690:
1683:
1674:
1673:
1669:
1661:
1642:
1628:
1618:
1608:
1575:
1565:
1555:
1530:
1519:10.5414/cpp39336
1501:
1455:
1454:
1444:
1434:
1417:(35): 12305–10.
1402:
1396:
1395:
1385:
1375:
1351:
1345:
1344:
1334:
1302:
1296:
1295:
1275:
1269:
1268:
1258:
1234:
1228:
1227:
1217:
1211:
1210:
1208:
1207:
1197:
1191:
1190:
1154:
1148:
1147:
1139:
1122:
1121:
1103:
1097:
1096:
1091:. Archived from
1060:
1011:The Decemberists
1003:Private Practice
945:Elizabeth Peters
876:conjugate esters
850:Pharmacokinetics
750:grapefruit juice
618:heart arrhythmia
594:heart arrhythmia
575:
574:
567:
509:
489:
474:
468:
462:
445:
434:
423:
422:
408:
406:
391:
371:
351:
331:
311:
291:
271:
251:
241:
240:
226:
168:
92:
38:
31:
29:
25:
4568:
4567:
4563:
4562:
4561:
4559:
4558:
4557:
4533:
4532:
4531:
4526:
4486:
4465:
4429:
4245:
4231:
4065:7β-Hydroxy-DHEA
4048:
3884:Levormeloxifene
3714:
3707:
3701:
3617:deoxymiroestrol
3485:-hinokiresinol)
3123:Methallenestril
3025:Doisynolic acid
2826:Methylestradiol
2341:7α-Hydroxy-DHEA
2232:
2222:
2214:
2184:
2179:
2178:
2163:Clinical trials
2138:
2120:
2091:
2052:Acetyldigitoxin
2025:
2021:Daigremontianin
2007:
1984:
1942:
1932:
1902:
1897:
1815:
1772:
1739:
1706:
1701:
1667:
1655:
1636:
1631:
1463:
1461:Further reading
1458:
1403:
1399:
1352:
1348:
1303:
1299:
1292:
1276:
1272:
1235:
1231:
1218:
1214:
1205:
1203:
1199:
1198:
1194:
1155:
1151:
1140:
1125:
1118:
1104:
1100:
1061:
1057:
1053:
1025:
934:Agatha Christie
927:
916:
914:Use as a weapon
892:
856:plasma proteins
852:
824:
818:
813:
725:corticosteroids
710:
682:
675:(high calcium).
630:
614:
604:and effects to
570:
568:
565:(what is this?)
562:
557:
554:
549:
544:
543:
532:
529:
524:
523:
512:
487:
477:
471:
465:
426:
402:
394:
374:
354:
334:
314:
294:
274:
254:
237:
229:
209:
206:
204:
199:
198:
166:
141:Protein binding
131:Bioavailability
123:Pharmacokinetic
117:
96:
60:
24:
17:
12:
11:
5:
4566:
4556:
4555:
4550:
4545:
4528:
4527:
4525:
4524:
4519:
4514:
4509:
4504:
4499:
4495:
4492:
4491:
4488:
4487:
4485:
4484:
4479:
4473:
4471:
4467:
4466:
4464:
4463:
4458:
4453:
4448:
4443:
4437:
4435:
4431:
4430:
4428:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4382:
4377:
4372:
4367:
4362:
4357:
4355:Hydroxytyrosol
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4293:
4288:
4283:
4278:
4273:
4268:
4263:
4257:
4255:
4248:
4237:
4236:
4233:
4232:
4230:
4229:
4220:
4219:
4210:
4209:
4204:
4199:
4194:
4189:
4184:
4179:
4174:
4169:
4164:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4070:Chloroindazole
4067:
4062:
4056:
4054:
4050:
4049:
4047:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4011:
4006:
4001:
3996:
3991:
3989:Spironolactone
3986:
3981:
3976:
3971:
3966:
3961:
3956:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3916:
3911:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3811:
3806:
3801:
3796:
3791:
3786:
3781:
3776:
3771:
3766:
3761:
3756:
3751:
3746:
3741:
3736:
3731:
3726:
3720:
3718:
3703:
3702:
3700:
3699:
3690:Others (e.g.,
3688:
3638:
3624:
3610:
3580:
3562:
3540:
3498:
3488:
3466:
3461:
3418:liquiritigenin
3327:
3313:
3291:
3265:Xenoestrogens:
3261:
3260:
3255:
3250:
3245:
3236:
3235:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3138:Paroxypropione
3135:
3130:
3125:
3120:
3115:
3107:
3099:
3094:
3089:
3088:
3087:
3077:
3072:
3067:
3062:
3057:
3052:
3050:Estrobin (DBE)
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3006:
3005:
2995:
2994:
2993:
2983:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2941:Allenolic acid
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2899:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2846:Norethisterone
2843:
2838:
2836:Mytatrienediol
2833:
2828:
2823:
2818:
2813:
2808:
2803:
2798:
2793:
2788:
2783:
2781:Ethylestradiol
2778:
2776:Ethinylestriol
2773:
2772:
2771:
2766:
2756:
2755:
2754:
2744:
2739:
2738:
2737:
2732:
2727:
2725:Estrone esters
2717:
2712:
2707:
2702:
2701:
2700:
2695:
2693:Estriol esters
2685:
2680:
2678:Estrapronicate
2675:
2670:
2665:
2664:
2663:
2658:
2653:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2569:
2568:
2558:
2553:
2548:
2543:
2538:
2533:
2503:
2498:
2496:Alestramustine
2493:
2488:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2448:
2443:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2396:16-Ketoestrone
2393:
2388:
2383:
2378:
2373:
2368:
2363:
2358:
2353:
2348:
2343:
2338:
2333:
2328:
2323:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2273:
2268:
2263:
2258:
2253:
2244:
2242:
2235:
2224:
2223:
2213:
2212:
2205:
2198:
2190:
2181:
2180:
2177:
2176:
2175:
2174:
2171:
2160:
2154:
2148:
2147:
2144:
2143:
2140:
2139:
2137:
2136:
2130:
2128:
2122:
2121:
2119:
2118:
2113:
2111:k-Strophanthin
2108:
2101:
2099:
2093:
2092:
2090:
2089:
2084:
2079:
2074:
2069:
2064:
2059:
2054:
2048:
2046:
2037:
2031:
2030:
2027:
2026:
2024:
2023:
2017:
2015:
2009:
2008:
2006:
2005:
2000:
1998:Proscillaridin
1994:
1992:
1986:
1985:
1983:
1982:
1977:
1972:
1967:
1961:
1959:
1950:
1948:Bufadienolides
1944:
1943:
1931:
1930:
1923:
1916:
1908:
1899:
1898:
1896:
1895:
1890:
1885:
1880:
1879:
1878:
1873:
1868:
1858:
1853:
1848:
1847:
1846:
1841:
1831:
1825:
1823:
1817:
1816:
1814:
1813:
1808:
1803:
1798:
1793:
1788:
1782:
1780:
1774:
1773:
1771:
1770:
1765:
1760:
1755:
1749:
1747:
1741:
1740:
1738:
1737:
1732:
1727:
1722:
1716:
1714:
1708:
1707:
1700:
1699:
1692:
1685:
1677:
1671:
1670:
1635:
1634:External links
1632:
1630:
1629:
1591:(20): 7693–8.
1576:
1531:
1502:
1464:
1462:
1459:
1457:
1456:
1397:
1346:
1311:Oncoimmunology
1297:
1290:
1270:
1229:
1212:
1192:
1149:
1123:
1116:
1098:
1095:on 2013-01-05.
1054:
1052:
1049:
1024:
1021:
1007:
1006:
1000:
997:
991:
984:
977:
974:
961:
953:
942:
926:
923:
915:
912:
891:
888:
874:(>2%), and
851:
848:
820:Main article:
817:
814:
812:
809:
808:
807:
797:
795:St John's Wort
780:
770:
769:
759:
752:
742:clarithromycin
727:
717:
709:
706:
700:. Antidigoxin
681:
678:
677:
676:
669:hypomagnesemia
657:
629:
626:
613:
610:
577:
576:
559:
558:
556:
555:
552:
550:
547:
539:
538:
537:
534:
533:
531:
530:
527:
519:
518:
517:
514:
513:
511:
510:
502:
500:
492:
491:
485:
479:
478:
475:
469:
463:
458:
452:
451:
447:
446:
436:
428:
427:
425:
424:
411:
409:
396:
395:
393:
392:
384:
382:
376:
375:
373:
372:
364:
362:
356:
355:
353:
352:
344:
342:
336:
335:
333:
332:
324:
322:
316:
315:
313:
312:
304:
302:
296:
295:
293:
292:
284:
282:
276:
275:
273:
272:
264:
262:
256:
255:
253:
252:
244:
242:
231:
230:
228:
227:
219:
217:
211:
210:
208:
207:
202:
194:
193:
192:
189:
188:
184:
183:
180:
174:
173:
170:
161:
160:
153:
147:
146:
143:
137:
136:
135:98–100% (oral)
133:
127:
126:
119:
118:
116:
115:
111:
109:
103:
102:
98:
97:
95:
94:
81:
79:
73:
72:
63:
61:administration
55:
54:
51:
45:
44:
40:
39:
15:
9:
6:
4:
3:
2:
4565:
4554:
4551:
4549:
4546:
4544:
4541:
4540:
4538:
4523:
4520:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4497:
4496:
4493:
4483:
4480:
4478:
4475:
4474:
4472:
4468:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4438:
4436:
4432:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4390:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4305:
4301:
4297:
4294:
4292:
4289:
4287:
4284:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4258:
4256:
4252:
4249:
4244:
4238:
4228:
4225:
4222:
4221:
4218:
4215:
4212:
4211:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4122:
4118:
4114:
4110:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4061:
4058:
4057:
4055:
4051:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4005:
4002:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3980:
3977:
3975:
3972:
3970:
3969:Pipendoxifene
3967:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3804:Clomifenoxide
3802:
3800:
3797:
3795:
3792:
3790:
3787:
3785:
3782:
3780:
3779:Brilanestrant
3777:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3755:
3752:
3750:
3747:
3745:
3742:
3740:
3737:
3735:
3732:
3730:
3727:
3725:
3722:
3721:
3719:
3713:
3704:
3697:
3693:
3689:
3686:
3682:
3678:
3674:
3670:
3666:
3662:
3658:
3654:
3650:
3646:
3642:
3639:
3636:
3632:
3628:
3625:
3622:
3618:
3615:-like (e.g.,
3614:
3611:
3608:
3604:
3600:
3596:
3592:
3588:
3584:
3581:
3578:
3574:
3570:
3566:
3563:
3560:
3559:guggulsterone
3556:
3552:
3548:
3544:
3543:Phytosteroids
3541:
3538:
3534:
3530:
3526:
3522:
3518:
3514:
3510:
3506:
3502:
3499:
3496:
3492:
3489:
3486:
3484:
3478:
3477:enterolactone
3474:
3470:
3467:
3465:
3462:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3431:
3427:
3423:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3387:
3383:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3351:
3347:
3343:
3339:
3335:
3331:
3328:
3325:
3321:
3317:
3314:
3311:
3310:wedelolactone
3307:
3303:
3299:
3295:
3292:
3289:
3288:photoanethole
3285:
3281:
3277:
3273:
3269:
3266:
3263:
3262:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3238:
3237:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3143:Pentafluranol
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3112:
3108:
3106:
3104:
3100:
3098:
3095:
3093:
3090:
3086:
3083:
3082:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3004:
3001:
3000:
2999:
2996:
2992:
2989:
2988:
2987:
2984:
2982:
2979:
2977:
2974:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2903:Nonsteroidal:
2901:
2900:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2837:
2834:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2770:
2767:
2765:
2762:
2761:
2760:
2757:
2753:
2752:Ethandrostate
2750:
2749:
2748:
2745:
2743:
2740:
2736:
2733:
2731:
2728:
2726:
2723:
2722:
2721:
2718:
2716:
2713:
2711:
2708:
2706:
2703:
2699:
2696:
2694:
2691:
2690:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2662:
2659:
2657:
2654:
2652:
2649:
2648:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2605:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2567:
2564:
2563:
2562:
2561:Cloxestradiol
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2531:
2527:
2523:
2519:
2515:
2511:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2441:
2437:
2436:17α-Estradiol
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2279:
2277:
2274:
2272:
2269:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2249:
2246:
2245:
2243:
2239:
2236:
2231:
2225:
2221:
2218:
2211:
2206:
2204:
2199:
2197:
2192:
2191:
2188:
2172:
2170:
2167:
2166:
2164:
2161:
2158:
2155:
2153:
2150:
2149:
2145:
2135:
2132:
2131:
2129:
2127:
2123:
2117:
2114:
2112:
2109:
2106:
2103:
2102:
2100:
2098:
2094:
2088:
2085:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2057:Acetyldigoxin
2055:
2053:
2050:
2049:
2047:
2045:
2041:
2038:
2036:
2032:
2022:
2019:
2018:
2016:
2014:
2010:
2004:
2001:
1999:
1996:
1995:
1993:
1991:
1987:
1981:
1980:Marinobufagin
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1962:
1960:
1958:
1954:
1951:
1949:
1945:
1940:
1936:
1929:
1924:
1922:
1917:
1915:
1910:
1909:
1906:
1894:
1893:Thioglycoside
1891:
1889:
1886:
1884:
1881:
1877:
1874:
1872:
1869:
1867:
1864:
1863:
1862:
1859:
1857:
1856:Glycosylamine
1854:
1852:
1849:
1845:
1842:
1840:
1839:Bufadienolide
1837:
1836:
1835:
1832:
1830:
1827:
1826:
1824:
1822:
1818:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1783:
1781:
1779:
1775:
1769:
1768:1,6-Glycoside
1766:
1764:
1763:1,4-Glycoside
1761:
1759:
1756:
1754:
1751:
1750:
1748:
1746:
1742:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1717:
1715:
1713:
1709:
1705:
1698:
1693:
1691:
1686:
1684:
1679:
1678:
1675:
1665:
1659:
1654:
1650:
1649:
1648:
1646:
1641:
1626:
1622:
1617:
1612:
1607:
1602:
1598:
1594:
1590:
1586:
1582:
1577:
1573:
1569:
1564:
1559:
1554:
1549:
1545:
1541:
1537:
1532:
1528:
1524:
1520:
1516:
1513:(8): 336–43.
1512:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1476:(5): 475–83.
1475:
1471:
1466:
1465:
1452:
1448:
1443:
1438:
1433:
1428:
1424:
1420:
1416:
1412:
1408:
1401:
1393:
1389:
1384:
1379:
1374:
1369:
1365:
1361:
1357:
1350:
1342:
1338:
1333:
1328:
1324:
1320:
1317:(2): e23082.
1316:
1312:
1308:
1301:
1293:
1287:
1283:
1282:
1274:
1266:
1262:
1257:
1252:
1249:(5): 421–31.
1248:
1244:
1240:
1233:
1225:
1224:
1216:
1202:
1196:
1188:
1184:
1180:
1176:
1172:
1168:
1165:(7): 439–42.
1164:
1160:
1153:
1145:
1144:Austria-Codex
1138:
1136:
1134:
1132:
1130:
1128:
1119:
1113:
1109:
1102:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1059:
1055:
1048:
1046:
1045:digitoxigenin
1042:
1038:
1034:
1030:
1020:
1018:
1017:
1012:
1004:
1001:
998:
995:
992:
989:
985:
982:
978:
975:
973:
972:
967:
966:
962:
959:
958:
954:
952:
951:
946:
943:
941:
940:
935:
932:
931:
930:
922:
920:
911:
909:
905:
901:
897:
887:
885:
881:
877:
873:
869:
868:digitoxigenin
865:
861:
857:
847:
845:
841:
837:
833:
829:
823:
806:
805:colestyramine
802:
798:
796:
792:
788:
784:
781:
779:
775:
774:
773:
767:
763:
762:Beta blockers
760:
757:
753:
751:
747:
743:
739:
735:
731:
728:
726:
722:
718:
715:
714:
713:
705:
703:
699:
695:
691:
687:
674:
673:hypercalcemia
670:
666:
662:
658:
655:
651:
647:
643:
639:
635:
634:
633:
625:
623:
619:
609:
607:
603:
599:
595:
591:
590:heart failure
587:
583:
573:
566:
560:
551:
546:
545:
542:
535:
526:
525:
522:
515:
508:
504:
503:
501:
498:
493:
486:
484:
480:
459:
457:
453:
448:
444:
440:
437:
435:
433:ECHA InfoCard
429:
421:
417:
416:DTXSID0022933
413:
412:
410:
401:
397:
390:
386:
385:
383:
381:
377:
370:
366:
365:
363:
361:
357:
350:
346:
345:
343:
341:
337:
330:
326:
325:
323:
321:
317:
310:
306:
305:
303:
301:
297:
290:
286:
285:
283:
281:
277:
270:
266:
265:
263:
261:
257:
250:
246:
245:
243:
236:
232:
225:
221:
220:
218:
216:
212:
201:
200:
197:
190:
185:
181:
179:
175:
171:
169:
162:
158:
154:
152:
148:
144:
142:
138:
134:
132:
128:
124:
120:
113:
112:
110:
108:
104:
99:
91:
86:
83:
82:
80:
78:
74:
71:
67:
64:
62:
56:
52:
50:
46:
43:Clinical data
41:
37:
32:
22:
4543:Cardenolides
4223:
4213:
4137:Mepitiostane
4085:Epitiostanol
3954:Ormeloxifene
3879:Lasofoxifene
3789:Camizestrant
3784:Broparestrol
3774:Bazedoxifene
3696:rotundifuran
3645:alkylphenols
3595:β-zearalenol
3591:α-zearalenol
3577:stigmasterol
3569:β-sitosterol
3565:Phytosterols
3546:
3533:triclocarban
3529:methoxychlor
3482:
3464:Lavender oil
3458:tectorigenin
3390:formononetin
3264:
3239:
3110:
3102:
2902:
2886:Quinestradol
2876:Promestriene
2851:Noretynodrel
2715:Estromustine
2668:Estramustine
2603:
2510:testosterone
2247:
2097:Strophanthus
2082:Metildigoxin
2072:Lanatoside C
2061:
2035:Cardenolides
2003:Scilliroside
1965:Arenobufagin
1637:
1588:
1584:
1543:
1539:
1510:
1506:
1473:
1469:
1414:
1410:
1400:
1363:
1359:
1349:
1314:
1310:
1300:
1280:
1273:
1246:
1242:
1232:
1222:
1215:
1204:. Retrieved
1195:
1162:
1158:
1152:
1143:
1107:
1101:
1093:the original
1072:
1068:
1058:
1039:. Digitoxin
1026:
1014:
1008:
993:
987:
980:
969:
963:
955:
950:Die For Love
948:
937:
928:
917:
893:
883:
853:
844:chronotropic
840:bathmotropic
825:
811:Pharmacology
771:
746:itraconazole
711:
708:Interactions
683:
659:and certain
631:
615:
612:Medical uses
598:phytosteroid
581:
580:
569:
563:
389:ChEMBL254219
165:Elimination
107:Legal status
101:Legal status
4482:Zearalenone
4434:Antagonists
4410:Resveratrol
4375:Nonylphenol
4370:Niacinamide
4286:Bisphenol A
4276:Aldosterone
4105:Glyceollins
4053:Antagonists
4044:Zuclomifene
4039:Zindoxifene
3949:NNC 45-1506
3944:NNC 45-0781
3939:NNC 45-0320
3934:NNC 45-0095
3929:Nitromifene
3909:Miproxifene
3859:Fispemifene
3834:Enclomifene
3829:Droloxifene
3809:CN-55945-27
3754:Afimoxifene
3744:Acefluranol
3635:rhaponticin
3631:resveratrol
3627:Stilbenoids
3599:zearalenone
3587:zearalanone
3573:campesterol
3505:alternariol
3438:pinocembrin
3382:epicatechin
3354:biochanin A
3294:Chalconoids
3188:Terfluranol
3163:Quadrosilan
3035:Elacestrant
2936:Allenestrol
2811:Lynestrenol
2735:Estropipate
2705:Estrofurate
2556:Clomestrone
2536:Atrimustine
2486:Abiraterone
2440:alfatradiol
2159:from market
2087:Gitoformate
2077:Deslanoside
1975:Cinobufagin
1844:Cardenolide
1801:Glucuronide
1791:Galactoside
1758:β-Glycoside
1753:α-Glycoside
864:metabolized
836:dromotropic
766:bradycardia
764:add to the
698:arrhythmias
665:hypokalemia
638:bradycardia
490: g·mol
439:100.000.691
369:CHEBI:28544
203:(3β,5β)-3--
187:Identifiers
49:Trade names
4537:Categories
4425:Tectoridin
4405:Raloxifene
4380:Oleuropein
4227:Trilostane
4172:Prochloraz
4132:MDL-101906
4127:ICI-164384
4014:Trioxifene
4009:Toremifene
3979:Raloxifene
3964:Panomifene
3959:Ospemifene
3924:Nafoxidine
3814:Cyclofenil
3769:Arzoxifene
3749:Acolbifene
3681:phthalates
3649:bisphenols
3621:miroestrol
3525:methiocarb
3513:endosulfan
3501:Pesticides
3473:enterodiol
3454:tectoridin
3434:penduletin
3430:naringenin
3414:kaempferol
3330:Flavonoids
3324:psoralidin
3320:coumestrol
3316:Coumestans
3280:dianethole
3233:WAY-214156
3223:WAY-200070
3218:WAY-169916
3213:WAY-166818
3183:SKF-82,958
3148:Phenestrol
3128:Methestrol
3113:-Hexestrol
3105:-Butestrol
2986:Dienestrol
2966:Carbestrol
2951:Bifluranol
2946:Benzestrol
2891:Quinestrol
2841:Nilestriol
2683:Estrazinol
2616:Epimestrol
2606:-Estradiol
2588:Cyclotriol
2526:nandrolone
2501:Almestrone
2336:7-Oxo-DHEA
2248:Steroidal:
2220:modulators
2134:Peruvoside
1806:Rhamnoside
1786:Fructoside
1704:Glycosides
1540:BMC Cancer
1206:2021-09-14
1051:References
994:Murder 101
925:In fiction
791:rifampicin
738:metabolism
730:inhibitors
688:, namely:
646:ventricles
620:, such as
596:. It is a
495:3D model (
483:Molar mass
329:E90NZP2L9U
300:ChemSpider
260:IUPHAR/BPS
215:CAS Number
196:IUPAC name
151:Metabolism
4548:Estrogens
4420:Tamoxifen
4400:Quercetin
4340:Genistein
4320:Estradiol
4304:o',p'-DDE
4207:ZK-191703
4202:ZK-164015
4162:Phenytoin
4060:(R,R)-THC
3999:Tamoxifen
3974:Promensil
3899:LY-117018
3874:Idoxifene
3869:ICI-55548
3854:Femarelle
3839:Endoxifen
3799:Clomifene
3555:diosgenin
3551:digitalis
3547:digitoxin
3537:triclosan
3517:fenarimol
3450:quercetin
3426:myricetin
3422:mirificin
3410:glycitein
3402:genistein
3398:glabridin
3358:calycosin
3346:baicalein
3302:phloretin
3258:ZK-283197
3118:Mestilbol
3080:Hexestrol
3055:Fenestrel
3030:Efavirenz
2961:Butestrol
2916:2,8-DHHHC
2911:(S,S)-THC
2906:(R,R)-THC
2861:Pentolame
2856:Orestrate
2831:Moxestrol
2821:Mestranol
2786:Etynodiol
2646:Estradiol
2621:Equilenin
2583:Cyclodiol
2541:Bolandiol
2169:Phase III
2157:Withdrawn
2062:Digitoxin
2044:Digitalis
2013:Kalanchoe
1970:Bufotalin
1796:Glucoside
1645:Digitoxin
832:inotropic
787:phenytoin
721:diuretics
602:structure
582:Digitoxin
178:Excretion
167:half-life
59:Routes of
28:Digitoxin
4498:See also
4300:p,p'-DDT
4291:Daidzein
4281:Atrazine
4254:Agonists
4182:RU-58668
4177:RU-39411
4024:U-11555A
4019:TZE-5323
3764:Anordrin
3759:Anordiol
3692:agnuside
3669:parabens
3509:dieldrin
3481:nyasol (
3446:puerarin
3442:prunetin
3406:genistin
3394:glabrene
3366:daidzein
3362:catechin
3350:baicalin
3342:apigenin
3272:anethole
3060:FERb 033
2896:Tibolone
2881:RU-16117
2866:Prodiame
2801:Hippulin
2796:Hexolame
2641:Estetrol
2551:Butolame
2241:Agonists
2126:Thevetia
1821:Aglycone
1811:Riboside
1745:Geometry
1664:original
1653:Medscape
1625:15136726
1572:11532201
1527:11515708
1498:19894541
1490:11395576
1451:16105948
1392:23210930
1366:(1): 4.
1341:23525565
1265:18127991
1089:11525233
1023:Research
965:Rosewood
896:foxglove
862:. It is
801:antacids
783:inducers
690:anorexia
572:(verify)
280:DrugBank
172:7–8 days
77:ATC code
66:By mouth
4470:Unknown
4446:Estriol
4350:GPER-L2
4345:GPER-L1
4029:U-11634
3904:Menerba
3894:LN-2299
3889:LN-1643
3864:GW-7604
3819:D-15413
3651:(e.g.,
3643:(e.g.,
3629:(e.g.,
3613:Steroid
3585:(e.g.,
3567:(e.g.,
3545:(e.g.,
3503:(e.g.,
3495:cadmium
3493:(e.g.,
3471:(e.g.,
3469:Lignans
3370:daidzin
3334:7,8-DHF
3332:(incl.
3318:(e.g.,
3296:(e.g.,
3178:SERBA-2
3173:SC-4289
3168:SC-3296
3075:GTx-758
2971:D-15414
2921:β-LGND1
2871:Prolame
2720:Estrone
2688:Estriol
2626:Equilin
2508:(e.g.,
2421:16α-LE2
2116:Cymarin
2105:Ouabain
2067:Digoxin
1883:Saponin
1778:Glycone
1593:Bibcode
1442:1194917
1419:Bibcode
1383:3506989
1332:3601180
1256:2598854
1187:2324996
1179:1469187
981:Columbo
890:History
872:digoxin
716:calcium
686:digoxin
606:digoxin
488:764.950
456:Formula
289:DB01396
235:PubChem
224:71-63-6
155:Liver (
93:)
87: (
85:C01AA04
21:Digoxin
4365:Niacin
4360:Kepone
4217:ERX-11
4187:SS1020
4095:ERB-88
4090:ERA-90
3994:SS1010
3919:MRL-37
3284:dianol
3253:ERB-79
3248:ERA-45
3243:ERB-26
2976:DCW234
2931:AC-186
2598:DHEA-S
2530:esters
2514:esters
2366:8β-VE2
2152:WHO-EM
1990:Scilla
1623:
1616:419668
1613:
1570:
1560:
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1525:
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1449:
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1185:
1177:
1114:
1087:
1033:cancer
1029:cancer
748:, and
734:CYP3A4
694:nausea
521:SMILES
380:ChEMBL
349:D00297
309:389987
249:441207
157:CYP3A4
145:90–97%
4441:CCL18
4315:Equol
4197:ZB716
4167:PHTPP
4034:Y-134
3711:SERMs
3706:Mixed
3386:equol
3268:Anise
3097:M2613
1563:48150
1494:S2CID
1183:S2CID
584:is a
541:InChI
497:JSmol
360:ChEBI
4461:MIBE
4456:G-36
4451:G-15
4385:PCBs
4242:GPER
4152:MIBE
3685:PCBs
3677:PHBA
3673:PBBs
3521:HPTE
3378:EGCG
3276:anol
3111:meso
3103:meso
2593:DHEA
2528:and
2512:and
1957:Bufo
1939:C01A
1712:Bond
1621:PMID
1568:PMID
1523:PMID
1486:PMID
1447:PMID
1388:PMID
1337:PMID
1286:ISBN
1261:PMID
1175:PMID
1112:ISBN
1085:PMID
793:and
756:P-gp
723:and
340:KEGG
320:UNII
269:6782
125:data
4415:STX
4335:G-1
4296:DDT
4117:III
3665:DDT
3663:),
3661:BPS
3657:BPF
3653:BPA
3553:),
3483:cis
3374:ECG
2604:ent
1611:PMC
1601:doi
1589:101
1558:PMC
1548:doi
1515:doi
1478:doi
1437:PMC
1427:doi
1415:102
1378:PMC
1368:doi
1327:PMC
1319:doi
1251:PMC
1167:doi
1077:doi
1009:In
957:CSI
936:'s
884:and
846:).
803:or
648:),
405:EPA
239:CID
90:WHO
4539::
4302:,
4121:IV
4119:,
4115:,
4113:II
4111:,
3694:,
3683:,
3679:,
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