1837:" and casualties of almost 50,000 people. The Government of India cites this as one of the major consequences of a vulture species extinction. A major shift in the transfer of corpse pathogens from vultures to feral dogs and rats could lead to a disease pandemic, causing millions of deaths in a crowded country like India, whereas vultures' digestive systems safely destroy many species of such pathogens. Vultures are long-lived and slow to breed. They start breeding only at the age of six and only 50% of their young survive. Even if the government ban is fully implemented, it will take many years to revive the vulture population.
1501:" in sensitive persons or animal species, and potentially during long-term use in nonsensitive persons if resistance to side effects decreases with age. However, this side effect cannot be avoided merely by using a COX-2 selective inhibitor because, "Both isoforms of COX, COX-1 and COX-2, are expressed in the kidney... Consequently, the same precautions regarding renal risk that are followed for nonselective NSAIDs should be used when selective COX-2 inhibitors are administered." However, diclofenac appears to have a different mechanism of renal toxicity.
717:
694:
1175:
1195:
1211:
65:
1140:
1156:
6630:
6650:
6640:
56:
1727:
10962:
1411:(MHRA) said in June 2013 that the drug should not be used by people with serious underlying heart conditions – people who had had heart failure, heart disease or a stroke were advised to stop using it completely. As of 15 January 2015, the MHRA announced that diclofenac will be reclassified as a prescription-only medicine (POM) due to the risk of cardiovascular adverse events.
2999:
2956:
2055:
4060:
1859:
simulation showing that the drug could reduce the population of vultures by 1–8% annually. Spain's medicine agency presented simulations suggesting that the number of deaths would be quite small. A paper published in 2021 identified the first authenticated death of a vulture from diclofenac in Spain, a
1790:
that have been administered veterinary diclofenac, and are poisoned by the accumulated chemical, as vultures do not have a particular enzyme to break down diclofenac. At a meeting of the
National Wildlife Board in March 2005, the Government of India announced it intended to phase out the veterinary
1391:
In 2013, a study found major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events. Compared with placebo, of 1000 people allocated to diclofenac for a year, three more had major vascular events, one of which was fatal. Vascular death was
2514:
1866:
Diclofenac is on the
European Union's watch list because it pollutes the Baltic Sea. When the substance enters freshwater, it has an environmental impact and is considered more difficult to remove in wastewater treatment plants than, for example, ibuprofen. Harmful residues have been found in blue
1402:
in 2004, attention has focused on all the other members of the NSAIDs group, including diclofenac. Research results are mixed, with a meta-analysis of papers and reports up to April 2006 suggesting a relative increased rate of heart disease of 1.63 compared to nonusers. Professor Peter
Weissberg,
1418:
found no additional cardiovascular risk from diclofenac use. A very large study of 1,028,437 Danish users of various NSAIDs or coxibs found the "Use of the nonselective NSAID diclofenac and the selective cyclooxygenase-2 inhibitor rofecoxib was associated with an increased risk of cardiovascular
1701:
Voltaren and
Voltarol contain the sodium salt of diclofenac. In the United Kingdom, Voltarol can be supplied with either the sodium salt or the potassium salt, while Cataflam, sold in some other countries, is the potassium salt only. However, Voltarol Emulgel contains diclofenac diethylammonium
1370:
were increased by about a third by diclofenac, chiefly due to an increase in major coronary events. Compared with placebo, of 1000 patients allocated to diclofenac for a year, three more had major vascular events, one of which was fatal. Vascular death is increased significantly by diclofenac.
1858:
Despite the vulture crisis, diclofenac remains available in other countries including many in Europe. It was controversially approved for veterinary use in Spain in 2013 and continues to be available, despite Spain being home to around 90% of the
European vulture population and an independent
1504:
Studies in Spain showed diclofenac caused acute kidney failure in vultures when they ate the carcasses of animals that had recently been treated with it. Drug-sensitive species and individual humans are initially assumed to lack genes expressing specific drug detoxification
1470:
more often develop symptomatic liver disease than patients with rheumatoid arthritis. Liver function should be monitored regularly during long-term treatment. If used for the short-term treatment of pain or fever, diclofenac has not been found more hepatotoxic than other
2504:
1486:
Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac. Based on clinical trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 week after initiating treatment with
4477:
Triebskorn R, Casper H, Heyd A, Eikemper R, Köhler HR, Schwaiger J (2004). "Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part II: cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss)".
2506:
Opinion of the
Committee pursuant to Article 30(3) of Regulation (EC) No 726/2004 on the risk to vultures and other necrophagous bird populations in the European Union in connection with the use of veterinary medicinal products containing the substance
1439:
Gastrointestinal complaints are most often noted. The development of ulceration and/or bleeding requires immediate termination of treatment with diclofenac. Most patients receive a gastro-protective drug as prophylaxis during long-term treatment
1705:
In the United States, 1% diclofenac gel was approved by the FDA in 2007 as a prescription drug for the temporary relief of the pain of osteoarthritis of joints in the hands, knees and feet. In 2020, the FDA approved the gel formulation for
1474:
As of
December 2009, Endo, Novartis, and the US FDA notified healthcare professionals to add new warnings and precautions about the potential for elevation in liver function tests during treatment with all products containing diclofenac
1382:
to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in fetuses that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.
2984:
4548:
Triebskorn R, Casper H, Scheil V, Schwaiger J (2007). "Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)".
1403:
medical director of the
British Heart Foundation said, "However, the increased risk is small, and many patients with chronic debilitating pain may well feel that this small risk is worth taking to relieve their symptoms". Only
1515:
Mental health side effects have been reported. These symptoms are rare, but exist in significant enough numbers to include as potential side effects. These include depression, anxiety, irritability, nightmares, and psychotic
2941:
1801:
have the same vulnerability to diclofenac as Old World vultures, and are therefore at a similar risk from its effects. Diclofenac has been shown also to harm freshwater fish species such as rainbow trout. In contrast,
2003:
4433:
Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD (2004). "Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout".
3125:
Solomon DH, Avorn J, Stürmer T, Glynn RJ, Mogun H, Schneeweiss S (May 2006). "Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk".
4699:
1879:
is banned in some countries, diclofenac is approved as a veterinary medication in others; it is used in the treatment of pets as well as in livestock. In some species of birds, diclofenac causes accumulation of
1482:
has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver
1819:"The loss of tens of millions of vultures over the last decade has had major ecological consequences across the Indian subcontinent that pose a potential threat to human health. In many places, populations of
1121:
In many countries, eye drops are sold to treat acute and chronic nonbacterial inflammation of the anterior part of the eyes (such as postoperative states). The eye drops have also been used to manage pain for
2454:
Moreno-Opo R, Carapeto R, Casimiro R, Rubio C, Muñoz B, Moreno I, et al. (2021). "The veterinary use of diclofenac and vulture conservation in Spain: Updated evidence and socio-ecological implications".
3893:
Fowler PD, Shadforth MF, Crook PR, John VA (1983). "Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis".
4090:
4637:
4120:
6686:
2976:
1775:
Use of diclofenac for animals is controversial due to toxicity when eaten by scavenging birds that eat dead animals; the medication has been banned for veterinary use in several countries.
2552:
4411:
3858:
Ortiz MI, Torres-López JE, Castañeda-Hernández G, Rosas R, Vidal-Cantú GC, Granados-Soto V (March 2002). "Pharmacological evidence for the activation of K(+) channels by diclofenac".
2221:
1795:
is a safer alternative to replace use of diclofenac. It is more expensive than diclofenac, but the cost is dropping as more pharmaceutical companies are beginning to manufacture it.
1702:
1.16%, being equivalent to 1% sodium salt. In 2016, Voltarol was one of the biggest selling branded over-the-counter medications sold in Great
Britain, with sales of £39.3 million.
286:
9037:
3245:
2929:
4936:
4668:
4751:
1600:
and COX-2. Drug developers have focused on selective COX-2 inhibition, particularly as a way to minimize the gastrointestinal side effects of NSAIDs. In practice, use of some
4781:
4142:
Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, et al. (February 2004). "Diclofenac residues as the cause of vulture population decline in
Pakistan".
9348:
3018:"Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials"
4729:
4972:
4691:
2620:
Dutta NK, Mazumdar K, Dastidar SG, Park JH (2007). "Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice".
6679:
1713:
In January 2015, diclofenac oral preparations were reclassified as prescription-only medicines in the UK. The topical preparations are available without prescription.
3574:
3531:
8408:
1423:, 1.91; 95% confidence interval, 1.62 to 2.42; and odds ratio, 1.66; 95% confidence interval, 1.06 to 2.59, respectively), with a dose-dependent increase in risk."
3774:
Gwanyanya A, Macianskiene R, Mubagwa K (October 2012). "Insights into the effects of diclofenac and other non-steroidal anti-inflammatory agents on ion channels".
4082:
9489:
1619:-inhibition, a number of other molecular targets of diclofenac possibly contributing to its pain-relieving actions have recently been identified. These include:
2034:
7210:
4058:, Pfister R, Sallmann A, "Process for the production of new substituted phenylacetic acids", issued 26 January 1978, assigned to Ciba Geigy AG
1556:
The main target in inhibition of prostaglandin synthesis appears to be the transiently expressed prostaglandin-endoperoxide synthase-2 (PGES-2), also known as
6672:
6633:
211:
5702:
2879:"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials"
2193:
1289:
1593:, which may be relevant to its mechanism of action. These additional actions may explain its high potency – it is the most potent NSAID on a broad basis.
4112:
1408:
4242:
Naidoo V, Swan GE (2009). "Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction".
3736:
Fei XW, Liu LY, Xu JG, Zhang ZH, Mei YA (August 2006). "The non-steroidal anti-inflammatory drug, diclofenac, inhibits Na(+) current in rat myoblasts".
1407:
was found not to increase the risk of heart disease; however, this is known to have a higher rate of gastric ulceration than diclofenac. In Britain the
10249:
10219:
10050:
847:
4820:
2170:
9255:
8875:
3811:"Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors"
3472:
Dastidar SG, Ganguly K, Chaudhuri K, Chakrabarty AN (April 2000). "The anti-bacterial action of diclofenac shown by inhibition of DNA synthesis".
10102:
10082:
9638:
9588:
6050:
4965:
10408:
9873:
9763:
9758:
9743:
9678:
9628:
9583:
9148:
7509:
1103:. Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is also present.
2544:
11017:
10815:
10646:
10636:
10060:
9738:
9718:
9703:
9693:
9673:
9668:
9623:
9598:
9563:
9409:
9240:
9018:
8916:
8855:
8816:
8615:
8605:
8513:
8401:
4403:
1661:
Diclofenac was first synthesized by Alfred Sallmann and Rudolf Pfister in 1973. The name "diclofenac" derives from its chemical name: 2-(2,6-
93:
1174:
10845:
10840:
10805:
10780:
10641:
10502:
10359:
9960:
9955:
9753:
9733:
9728:
9723:
9708:
9698:
9688:
9663:
9653:
9648:
9643:
9633:
9618:
9613:
9573:
9532:
9512:
9469:
9464:
9449:
9439:
9434:
9419:
9298:
9220:
9175:
9089:
9065:
9055:
8503:
5089:
4782:"First evidence of a vulture killed by veterinary diclofenac in Spain – will the Spanish government and the EU act after this smoking gun?"
4065:
1358:
Diclofenac consumption has been associated with significantly increased vascular and coronary risk in a study including coxib, diclofenac,
1210:
1060:, during which in a few years 95% of the country's vulture population was killed, and in many countries agricultural use is now forbidden.
803:
3255:
10830:
10785:
10596:
10542:
10527:
10376:
10087:
10035:
9920:
9768:
9713:
9683:
9658:
9608:
9603:
9593:
9578:
9527:
9522:
9479:
9414:
9404:
9374:
9318:
9288:
9245:
9235:
9084:
9008:
8860:
8773:
8570:
7457:
6349:
6125:
3701:
Cryer B, Feldman M (May 1998). "Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs".
2667:
1478:
Cases of drug-induced hepatotoxicity have been reported in the first month, but can occur at any time during treatment with diclofenac.
1194:
10835:
10810:
10800:
10651:
10626:
10611:
10576:
10552:
10547:
10298:
9748:
9568:
9502:
9474:
9459:
9454:
9429:
9045:
9013:
8993:
8936:
8821:
8744:
8739:
8734:
8729:
8565:
8560:
6065:
6025:
5680:
4958:
3103:
4660:
10938:
10855:
10571:
10517:
10512:
9547:
9394:
9303:
9260:
8811:
8724:
8610:
8590:
8585:
8580:
4759:
1566:
Diclofenac has a relatively high lipid solubility, making it one of the few NSAIDs that are able to enter the brain by crossing the
10717:
10621:
10616:
9424:
9389:
9265:
9225:
8394:
6643:
5695:
4295:
3357:
1139:
9507:
9356:
4789:
2840:
2758:
1926:
1867:
mussels and fish, among others, where it has been found to cause damage to internal organs such as the gills, kidneys and liver.
1155:
4721:
4324:
8352:
6608:
4039:
2346:
2322:
2296:
2230:
2164:
1560:(COX-2). That is, diclofenac is partially selective for COX-2. It inhibits COX-2 approximately four times as much as COX-1.
11022:
6960:
6716:
5711:
3554:
3511:
1782:
population in the Indian subcontinent – a 95% decline by 2003 and a 99.9% decline by 2008. The mechanism is presumed to be
789:
4593:
2580:
2246:
Chung CH (2017). "The use of Injectable Nonsteroidal Anti-Inflammatory Drugs in Local Accident & Emergency Practice".
7968:
7529:
7497:
6289:
5688:
1367:
1353:
1133:, especially if inflammation is present. Use of 1% diclofenac gel should not exceed 32 g (32,000 mg) in a day.
960:
3073:
2681:
1612:, yet other significantly COX-selective NSAIDs, such as diclofenac, have been well tolerated by most of the population.
11027:
4522:
1786:; however, toxicity may be due to direct inhibition of uric acid secretion in vultures. Vultures eat the carcasses of
854:
144:
823:
8369:
3631:
Ku EC, Lee W, Kothari HV, Scholer DW (April 1986). "Effect of diclofenac sodium on the arachidonic acid cascade".
3171:"Cause-specific cardiovascular risk associated with nonsteroidal antiinflammatory drugs among healthy individuals"
2930:"FDA Warns that Using a Type of Pain and Fever Medication in Second Half of Pregnancy Could Lead to Complications"
9384:
443:
271:
125:
4594:"Apparent tolerance of turkey vultures (Cathartes aura) to the non-steroidal anti-inflammatory drug diclofenac"
3381:"Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase"
2197:
1053:
million prescriptions. It is available as its acid or in two salts, as either diclofenac sodium or potassium.
514:
10931:
7824:
7467:
3991:"Selective modification of diclofenac to reduce the adverse effects; A computer-aided drug design approach"
3250:
2935:
2039:
1596:
Marked differences exist among NSAIDs in their selective inhibition of the two subtypes of cyclooxygenase,
1375:
1336:
1035:
712:
565:
4812:
1577:
Diclofenac may be a unique member of the NSAIDs in other aspects. Some evidence indicates it inhibits the
8523:
8466:
4941:
2144:
1975:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
673:
38:
5710:
4850:
2502:
1649:) than the drug's 1.2–2 h half-life. This could be partly because it persists for over 11 hours in
10952:
8946:
8831:
8754:
8647:
7487:
1627:(after activation of the channel, diclofenac inhibits its reactivation, also known as phase inhibition)
1479:
1340:
1271:
10888:
2606:
634:
8629:
8448:
6664:
5653:
5508:
4843:"Itämeren kalat häiriintyvät lääkeaineista – Teollisuudella paineita kehittää eettisempiä pillereitä"
2763:
1974:
1266:
1015:
17:
5431:
5324:
1049:
In 2022, it was the 51st most commonly prescribed medication in the United States, with more than 12
10725:
10706:
10661:
9103:
8202:
8163:
6953:
6587:
5387:
1570:. As in the rest of the body, it is thought to exert its effect in the brain through inhibition of
1285:
831:
InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
689:
8431:
8357:
8073:
7477:
7133:
6612:
5584:
5315:
3942:"Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology"
1567:
1497:
NSAIDs "are associated with adverse renal effects caused by the reduction in synthesis of renal
1185:
988:
181:
80:
4055:
3210:
FitzGerald GA, Patrono C (August 2001). "The coxibs, selective inhibitors of cyclooxygenase-2".
10767:
10687:
8121:
7077:
5579:
3666:
Scholer DW, Ku EC, Boettcher I, Schweizer A (April 1986). "Pharmacology of diclofenac sodium".
3169:
Fosbøl EL, Folke F, Jacobsen S, Rasmussen JN, Sørensen R, Schramm TK, et al. (July 2010).
1645:
The duration of action (i.e., duration of pain relief) of a single dose is longer (6 to 8
1332:
1302:
1088:
1000:
655:
347:
2312:
2072:
614:
11012:
11007:
10992:
10982:
10744:
9200:
8437:
7880:
7574:
7492:
7482:
7194:
7137:
6592:
6582:
6577:
6567:
5422:
5168:
5109:
2655:
2398:
Cuthbert RJ, Taggart MA, Prakash V, Chakraborty SS, Deori P, Galligan T, et al. (2014).
1893:
1770:
1707:
1605:
1057:
992:
980:
968:
505:
192:
3095:
2711:"Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions"
2116:
103:
10997:
10883:
10005:
9858:
9328:
8091:
8052:
7885:
7875:
7870:
7697:
7502:
7418:
7060:
6562:
6539:
6020:
5892:
5644:
5345:
5276:
5177:
4605:
4487:
4443:
4151:
3596:
Gan TJ (July 2010). "Diclofenac: an update on its mechanism of action and safety profile".
3392:
2464:
574:
469:
401:
9166:
9075:
4950:
554:
8:
9833:
7840:
7472:
7301:
7202:
7141:
7028:
7017:
6946:
6616:
6572:
6489:
5867:
5461:
5364:
5263:
5044:
5015:
4592:
Rattner BA, Whitehead MA, Gasper G, Meteyer CU, Link WA, Taggart MA, et al. (2008).
3349:
2709:
Wakai A, Lawrenson JG, Lawrenson AL, Wang Y, Brown MD, Quirke M, et al. (May 2017).
1876:
1526:
1239:
1181:
976:
460:
188:
4609:
4491:
4447:
4287:
4155:
3396:
2877:
Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. (August 2013).
2468:
2404:
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
1748:
Please expand the section to include this information. Further details may exist on the
716:
693:
10695:
8423:
8278:
7845:
7743:
7414:
7272:
7206:
6917:
6695:
6479:
6412:
5084:
5054:
4903:
4629:
4574:
4379:
4352:
4219:
4194:
4175:
3966:
3941:
3919:
3835:
3826:
3810:
3331:
3151:
3042:
3017:
2903:
2878:
2769:
2735:
2710:
2424:
2399:
2263:
2156:
1279:
1275:
1031:
996:
204:
155:
3871:
3714:
3485:
3290:
3273:
2894:
2832:
2633:
1918:
10987:
10229:
9898:
9868:
8062:
7917:
7905:
7792:
7198:
6848:
6649:
6509:
6359:
5922:
5897:
5614:
5594:
5529:
5188:
5183:
5079:
4895:
4633:
4621:
4566:
4503:
4459:
4384:
4269:
4224:
4167:
4035:
4012:
3971:
3911:
3875:
3840:
3791:
3787:
3753:
3718:
3683:
3679:
3648:
3644:
3613:
3566:
3523:
3489:
3447:
3420:
3415:
3380:
3295:
3227:
3192:
3143:
3047:
2908:
2814:
2809:
2792:
2740:
2637:
2480:
2429:
2318:
2292:
2226:
2160:
1860:
1803:
1779:
1778:
Use of diclofenac in animals has been reported to have led to a sharp decline in the
1739:
1638:
1530:
1309:
1256:
1111:
1110:
but not other types of long-term musculoskeletal pain. Diclofenac may also help with
645:
310:
298:
117:
4907:
4578:
4179:
3335:
3246:"Voltaren Gel (diclofenac sodium topical gel) 1% – Hepatic Effects Labeling Changes"
3187:
3170:
2476:
2267:
1641:(diclofenac opens these channels, leading to hyperpolarization of the cell membrane)
1395:
Following the identification of increased risks of heart attacks with the selective
10911:
10903:
10898:
10202:
9788:
9279:
9158:
8984:
8975:
8907:
8898:
8890:
8792:
8783:
8705:
8696:
8547:
8485:
8139:
7613:
6273:
5554:
5544:
4885:
4613:
4558:
4495:
4451:
4374:
4364:
4320:
4259:
4251:
4214:
4206:
4159:
4002:
3961:
3953:
3923:
3903:
3867:
3830:
3822:
3783:
3745:
3710:
3675:
3640:
3605:
3481:
3410:
3400:
3323:
3285:
3219:
3182:
3155:
3135:
3037:
3029:
2898:
2890:
2804:
2730:
2726:
2722:
2629:
2472:
2419:
2411:
2255:
2152:
2035:"FDA Approves Three Drugs for Nonprescription Use Through Rx-to-OTC Switch Process"
1852:
1590:
1123:
914:
870:
729:
339:
254:
244:
234:
224:
8386:
4499:
4455:
4193:
Swan GE, Cuthbert R, Quevedo M, Green RE, Pain DJ, Bartels P, et al. (2006).
3379:
Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR (December 1993).
2368:
2338:
1948:
1698:
Diclofenac formulations are available worldwide under many different brand names.
1106:
Diclofenac is also available in topical forms and has been found to be useful for
11002:
10966:
10759:
10691:
10601:
10276:
10254:
10224:
8921:
8323:
8242:
8224:
8037:
7802:
7787:
7728:
7111:
7012:
6747:
6653:
6391:
6381:
6339:
5805:
5723:
5639:
5589:
5514:
5299:
5196:
5094:
4995:
4931:
4369:
4069:
3609:
3096:"Press release: Diclofenac tablets now only available as a prescription medicine"
1749:
1601:
1571:
1557:
1550:
1396:
1146:
1069:
1027:
494:
391:
375:
357:
31:
6977:
6973:
5719:
5715:
3439:
3223:
2503:
European Medicines Agency, Committee for Medicinal Products for Veterinary Use,
64:
10281:
10234:
9799:
9361:
8420:
8363:
8318:
8081:
7961:
7936:
7812:
7797:
7267:
7147:
7098:
7065:
6752:
6365:
6140:
6005:
5917:
5842:
5827:
5822:
5816:
5745:
5471:
5374:
5304:
5212:
5201:
5154:
5025:
4982:
4351:
Swan G, Naidoo V, Cuthbert R, Green RE, Pain DJ, Swarup D, et al. (2006).
4255:
3989:
Hasan MK, Akhter S, Fatema K, Hossain MR, Sultana T, Uzzaman M (January 2023).
3749:
3385:
Proceedings of the National Academy of Sciences of the United States of America
2584:
2259:
1896:
after feeding on carcasses of livestock that had been treated with diclofenac.
1841:
1807:
1783:
1650:
1624:
1616:
1542:
1467:
1379:
1328:
Can lead to onset of new hypertension or worsening of pre-existing hypertension
1107:
1011:
4890:
4873:
4692:"'Decline in vulture population has given rise to diseases': Dr Vibhu Prakash"
4562:
4007:
3990:
3957:
3327:
3033:
3016:
Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C (June 2006).
2565:...diclofenac has already been banned in India, Pakistan, Nepal and Bangladesh
1466:
may occur rarely without any warning symptoms and may be fatal. Patients with
1322:, as it induces (often severe) capillary leakage and subsequent heart failure.
1018:, nausea, dizziness, headache, and swelling. Serious side effects may include
10976:
10878:
10562:
10347:
10244:
10122:
10107:
10040:
9970:
8252:
8247:
8237:
8167:
8129:
7587:
7362:
7292:
7152:
7121:
7070:
6863:
6499:
6376:
6189:
6174:
6055:
5990:
5634:
5499:
5248:
5102:
4926:
4323:(Press release). Press Information Bureau, Government of India. 16 May 2005.
4016:
3405:
3065:
3003:
2960:
2692:
2059:
2008:
1885:
1498:
1295:
Pain management in the setting of coronary artery bypass graft (CABG) surgery
1043:
1039:
1019:
705:
323:
196:
30:"Diclo" redirects here. For the organic solvent sometimes called Di-clo, see
4722:"E-010588/2015: answer given by Mr Andriukaitis on behalf of the Commission"
1810:, can tolerate at least 100 times the level of diclofenac that is lethal to
1315:
Caution in patients with severe, active bleeding such as cerebral hemorrhage
10418:
10335:
10261:
10239:
10192:
10127:
10097:
10077:
10072:
9995:
9883:
9308:
9270:
9138:
8965:
8801:
8686:
8493:
8257:
8232:
7990:
7895:
7779:
7566:
7554:
7544:
7519:
7387:
7377:
7307:
7182:
7177:
7088:
6922:
6868:
6828:
6742:
6729:
6707:
6371:
6334:
6319:
6263:
6248:
6243:
6194:
6169:
6159:
6154:
5912:
5790:
5770:
5765:
5755:
5737:
5669:
5619:
5604:
5549:
5478:
5456:
5450:
5410:
5379:
5359:
5353:
5286:
5271:
5253:
5220:
5132:
5120:
5069:
5064:
5010:
5004:
4986:
4899:
4625:
4570:
4507:
4463:
4388:
4353:"Removing the threat of diclofenac to critically endangered Asian vultures"
4273:
4228:
4210:
4171:
4113:"Oral diclofenac presentations with legal status 'P' – reclassified to POM"
3975:
3879:
3844:
3795:
3757:
3617:
3570:
3527:
3493:
3451:
3299:
3231:
3196:
3147:
3051:
2912:
2818:
2744:
2641:
2484:
2433:
2415:
1833:
carcasses. Associated with the rise in dog numbers is an increased risk of
1798:
1743:
1682:
1609:
1578:
1319:
1262:
1235:
1217:
1092:
1084:
1080:
249:
239:
229:
219:
47:
6938:
3915:
3722:
3687:
3652:
3424:
1884:
crystals in internal organs—especially the liver and kidneys—resulting in
10893:
10795:
10736:
10606:
10591:
10532:
10497:
10475:
10455:
10403:
10388:
10330:
10288:
10214:
10182:
10167:
10000:
9985:
9910:
9848:
9843:
9517:
9190:
9153:
9128:
9123:
8970:
8926:
8885:
8880:
8778:
8714:
8691:
8681:
8600:
8575:
8542:
8508:
8303:
8283:
8192:
8101:
8032:
8024:
7985:
7910:
7860:
7855:
7754:
7690:
7618:
7462:
7447:
7438:
7372:
7357:
7352:
7342:
7337:
7332:
7282:
7262:
7257:
7252:
7221:
7216:
7172:
7157:
7126:
7105:
7083:
6901:
6838:
6813:
6803:
6762:
6607:
indicates initially developed first-in-class compound of specific group;
6504:
6484:
6453:
6438:
6329:
6294:
6283:
6093:
6015:
5943:
5932:
5882:
5877:
5659:
5649:
5629:
5624:
5539:
5519:
5494:
5442:
5437:
5340:
5335:
5330:
5240:
5230:
5138:
5115:
4083:"A breakdown of the over-the-counter medicines market in Britain in 2016"
3857:
3512:"Diclofenac: update on tolerableness and spinal anti-inflammatory action"
2663:
1848:
1631:
1582:
1534:
1441:
1201:
1165:
1130:
1004:
984:
200:
111:
4163:
534:
10825:
10586:
10557:
10537:
10490:
10485:
10470:
10445:
10413:
10381:
10352:
10308:
10207:
10157:
10152:
10147:
10142:
10117:
10030:
10025:
9950:
9930:
9915:
9888:
9863:
9853:
9838:
9828:
9542:
9497:
9484:
9399:
9185:
9180:
9133:
9070:
9050:
9003:
8595:
8417:
8333:
8328:
8273:
8210:
8153:
8134:
8111:
8106:
8096:
8086:
8047:
8010:
8005:
8000:
7951:
7946:
7928:
7865:
7850:
7835:
7769:
7749:
7670:
7639:
7593:
7580:
7549:
7514:
7397:
7392:
7367:
7317:
7312:
7287:
7242:
7167:
6927:
6878:
6858:
6843:
6699:
6534:
6524:
6519:
6514:
6463:
6428:
6278:
6226:
6221:
6216:
6211:
6184:
6108:
6045:
5978:
5953:
5948:
5887:
5872:
5862:
5832:
5800:
5785:
5732:
5664:
5609:
5599:
5405:
5291:
5149:
5125:
5074:
5059:
5039:
5033:
3907:
3378:
1820:
1563:
The drug may be bacteriostatic via inhibiting bacterial DNA synthesis.
1449:
1445:
1420:
1056:
It is also widely used for livestock; such use was responsible for the
999:. Improvements in pain last up to eight hours. It is also available in
765:
545:
6694:
4264:
4244:
Comparative Biochemistry and Physiology. Toxicology & Pharmacology
3505:
3503:
3139:
2291:(74 ed.). British Medical Association. 2017. pp. 1033–1035.
1541:
action is thought to be inhibition of prostaglandin synthesis through
10850:
10790:
10522:
10480:
10465:
10460:
10450:
10440:
10435:
10430:
10425:
10340:
10323:
10318:
10313:
10197:
10177:
10172:
10137:
10132:
10092:
10065:
10020:
10015:
10010:
9990:
9945:
9940:
9903:
9893:
9818:
9537:
9444:
9293:
9230:
9143:
9060:
8865:
8850:
8671:
8666:
8338:
8298:
8293:
8147:
7995:
7956:
7900:
7830:
7764:
7759:
7736:
7718:
7703:
7675:
7654:
7649:
7644:
7603:
7559:
7347:
7322:
7187:
7116:
7044:
6969:
6892:
6873:
6833:
6823:
6808:
6777:
6737:
6529:
6494:
6458:
6448:
6443:
6433:
6423:
6418:
6407:
6401:
6354:
6268:
6253:
6238:
6206:
6200:
6164:
6130:
6119:
6113:
6075:
6040:
6035:
6030:
6010:
5973:
5968:
5902:
5857:
5810:
5775:
5760:
5573:
5564:
5466:
5393:
5369:
5281:
5048:
5020:
4617:
2121:
1881:
1792:
1787:
1538:
1463:
1427:
1399:
1359:
1247:
1161:
1096:
1076:
480:
418:
383:
97:
2656:"Diclofenac (Topical Application Route) Description and Brand Names"
10683:
10678:
10507:
10369:
10364:
10303:
10293:
10271:
10266:
10187:
10162:
10112:
10055:
10045:
9980:
9975:
9935:
9250:
8870:
8676:
8308:
8187:
8182:
8042:
7941:
7713:
7708:
7685:
7634:
7608:
7598:
7407:
7402:
7382:
7297:
7277:
7226:
7039:
7024:
6853:
6818:
6798:
6782:
6344:
6324:
6310:
6258:
6232:
6179:
6103:
6098:
6070:
6060:
6000:
5995:
5963:
5795:
5780:
5750:
5569:
5534:
5524:
5504:
5225:
5144:
3500:
3471:
2145:"Nonopioid analgesics: NSAIDs, COX-2 inhibitors, and acetaminophen"
1889:
1830:
1674:
1586:
1363:
1243:
1100:
594:
525:
139:
4523:"Subletale Wirkungen von Arzneimitteln bei aquatischen Organismen"
2691:. Netherlands: Netherlands Medicines Authority MEB. Archived from
1608:
has led to massive numbers of lawsuits alleging wrongful death by
788:
661:
10820:
10631:
10398:
9925:
9878:
9823:
9369:
8313:
8288:
8158:
8143:
7890:
7820:
7452:
7424:
7247:
7162:
7007:
6703:
6544:
6145:
5958:
5907:
5851:
3002:
This article incorporates text from this source, which is in the
2959:
This article incorporates text from this source, which is in the
2400:"Avian scavengers and the threat from veterinary pharmaceuticals"
2397:
2058:
This article incorporates text from this source, which is in the
1855:, but are now compelled to seek alternative methods of disposal.
1678:
1673:
etic acid. It was patented in Germany in 1978 by Ciba-Geigy (now
1404:
1251:
1042:. Diclofenac is believed to work by decreasing the production of
4432:
3318:
Becker R (2016). "Cattle drug threatens thousands of vultures".
2599:"Patient Site – Cambia (diclofenac potassium) for oral solution"
2222:
Mosby's Dictionary of Medicine, Nursing & Health Professions
1726:
10581:
9782:
7093:
6995:
6986:
6085:
5159:
4945:
4547:
2453:
1844:
1834:
1115:
1023:
625:
379:
371:
367:
363:
3940:
Altman R, Bosch B, Brune K, Patrignani P, Young C (May 2015).
3808:
2369:"Diclofenac Drug Usage Statistics, United States, 2013 - 2022"
1681:
purchased the rights in 2015. Currently, it is available as a
10393:
7327:
7034:
6999:
4842:
4591:
3809:
Voilley N, de Weille J, Mamet J, Lazdunski M (October 2001).
1597:
1546:
1462:
Liver damage occurs infrequently, and is usually reversible.
1415:
1414:
A subsequent large study of 74,838 Danish users of NSAIDs or
779:
605:
428:
55:
4476:
3773:
3168:
2194:"Diclofenac Oral Uses, Dosage, Side Effects And Composition"
678:
5164:
4980:
4874:"Toxicological effects of diclofenac in four avian species"
3665:
2708:
2598:
1840:
The loss of vultures has had a social impact on the Indian
1825:
1812:
1646:
1574:. In addition, it may have effects inside the spinal cord.
1366:. Upper gastrointestinal complications were also reported.
1072:
972:
964:
938:
894:
888:
876:
585:
424:
410:
4525:[Sublethal effects of drugs in aquatic organisms]
3939:
3118:
2876:
1677:). It came into medical use in the United States in 1988.
929:
3274:"Renal effects of cyclooxygyenase-2-selective inhibitors"
3015:
2790:
2619:
2545:"Rare European vultures being poisoned by livestock drug"
1982:
1325:
Caution in patients with fluid retention or heart failure
1114:
and with acute pain caused by minor strains, sprains and
944:
920:
900:
37:"Dichronic" redirects here. For common misspellings, see
4872:
Hussain I, Khan MZ, Khan A, Javed I, Saleemi MK (2008).
4192:
3988:
3892:
3124:
2977:"NSAIDs may cause rare kidney problems in unborn babies"
4350:
4141:
2698:
on 4 March 2016 – via Medicines Information Bank.
2971:
2969:
10950:
4054:
1099:. An additional indication is the treatment of acute
947:
941:
935:
923:
903:
897:
891:
882:
4871:
2872:
2870:
2868:
2866:
2864:
2862:
2860:
2858:
2825:
2791:
Haroutiunian S, Drennan DA, Lipman AG (April 2010).
2147:. In Benzon HT, Raja SN, Liu SS, Fishman SM (eds.).
1829:
vultures as the main scavenger of wild and domestic
926:
917:
885:
873:
413:(35% of the drug enters enterohepatic recirculation)
8524:
8467:
8416:
4714:
4520:
3738:
Biochemical and Biophysical Research Communications
3630:
3100:
Medicines and Healthcare products Regulatory Agency
2966:
2142:
1967:
1409:
Medicines and Healthcare products Regulatory Agency
932:
879:
513:
9805:
8947:
8832:
8755:
8648:
4683:
2924:
2922:
2117:"Diclofenac epolamine Monograph for Professionals"
1941:
8630:
8449:
4752:"Vulture killing drug now available on EU market"
4661:"Rabies tragedy follows loss of India's vultures"
3209:
2855:
2073:"How Long Does It Take for Voltaren Gel to Work?"
1823:have increased sharply from the disappearance of
313:(Prescription only) / P / GSL
289:(Prescription only) / S3 / S2
69:Structure of diclofenac with ball and stick model
10974:
10726:
10707:
10662:
9104:
3175:Circulation: Cardiovascular Quality and Outcomes
2793:"Topical NSAID therapy for musculoskeletal pain"
2583:. Birzeit Pharmaceutical Company. Archived from
493:
3009:
2919:
2317:. Elsevier Health Sciences. 2017. p. 398.
2151:(3 ed.). W.B. Saunders. pp. 130–139.
1693:
1637:Positive allosteric modulation of KCNQ- and BK-
1298:Severe liver insufficiency (Child-Pugh Class C)
468:
10768:
4404:"Eagles fall prey to vulture-killing chemical"
1426:Diclofenac is similar in COX-2 selectivity to
1331:Can cause serious skin adverse events such as
10745:
9201:
8402:
6954:
6680:
5696:
4966:
3735:
3555:"Spinal antinflammatory action of Diclofenac"
3474:International Journal of Antimicrobial Agents
3313:
3311:
3309:
3267:
3265:
2622:International Journal of Antimicrobial Agents
2449:
2447:
2445:
2443:
2314:Mosby's Drug Reference for Health Professions
2143:Williams BS, Buvanendran A (1 January 2011).
1738:about environmental buildup, wastewater; try
9329:
4541:
4235:
4074:
3700:
3203:
3162:
143:
6968:
4865:
4346:
4344:
4342:
4023:
3886:
3659:
3437:
2715:The Cochrane Database of Systematic Reviews
2538:
2536:
2534:
2498:
2496:
2494:
2393:
2391:
2389:
2218:
2029:
2027:
1318:NSAIDs in general should be avoided during
1007:in an effort to decrease stomach problems.
331:In general: ℞ (Prescription only)
8409:
8395:
6961:
6947:
6687:
6673:
5703:
5689:
4973:
4959:
4315:
4313:
4241:
3306:
3262:
2440:
2111:
2109:
2107:
2105:
2103:
2101:
2099:
2097:
2095:
2093:
1129:Diclofenac is often used to treat chronic
715:
692:
553:
4889:
4689:
4378:
4368:
4263:
4218:
4195:"Toxicity of diclofenac to Gyps vultures"
4006:
3965:
3896:European Journal of Clinical Pharmacology
3834:
3694:
3465:
3414:
3404:
3289:
3186:
3041:
2902:
2808:
2734:
2613:
2423:
2196:. Medicine Reviews Agency. Archived from
573:
4935:) is being considered for deletion. See
4810:
4339:
4135:
4080:
3776:The Journal of Pharmacy and Pharmacology
2531:
2491:
2386:
2289:British national formulary : BNF 74
2283:
2281:
2279:
2277:
2245:
2225:(10th ed.). Elsevier. p. 536.
2191:
2024:
2004:"Product monograph brand safety updates"
4813:"Val av smärtstillande påverkar miljön"
4401:
4310:
4029:
3438:Alfaro RA, Davis DD (15 January 2024).
2248:Hong Kong Journal of Emergency Medicine
2090:
688:
533:
116:
14:
10975:
9800:
4658:
4598:Environmental Toxicology and Chemistry
4551:Analytical and Bioanalytical Chemistry
3552:
3509:
3317:
3284:(4 Suppl): S15–20, discussion S21–23.
3278:Journal of Pain and Symptom Management
3271:
3076:from the original on 20 September 2018
2670:from the original on 23 November 2013.
2575:
2573:
2239:
1688:
1308:Caution in patients with pre-existing
706:
396:Within 4 hours (gel), 30 min (non-gel)
304:
8390:
6942:
6668:
5712:Non-steroidal anti-inflammatory drugs
5684:
5085:Selenium disulfide (selenium sulfide)
4954:
4702:from the original on 15 December 2018
4327:from the original on 20 December 2005
4321:"Saving the Vultures from Extinction"
3935:
3933:
3769:
3767:
2759:"WHO's cancer pain ladder for adults"
2702:
2542:
2274:
1929:from the original on 22 December 2018
1716:
1581:pathways, thus reducing formation of
654:
633:
613:
317:
134:
102:
11018:Nonsteroidal anti-inflammatory drugs
10423:Selective COX-2 inhibitors (coxibs):
6639:
4298:from the original on 3 December 2013
4280:
4093:from the original on 8 December 2021
3598:Current Medical Research and Opinion
3360:from the original on 5 February 2013
3106:from the original on 22 January 2015
3066:"Heart risk warning over painkiller"
2987:from the original on 17 October 2020
2944:from the original on 16 October 2020
2609:from the original on 16 August 2011.
2457:The Science of the Total Environment
2173:from the original on 10 January 2023
1913:
1911:
1909:
1847:, who traditionally use vultures to
1720:
1305:(creatinine clearance <30 ml/min)
1225:
660:
253:
243:
233:
223:
8532:Tooltip Prostaglandin D2 receptor 2
8475:Tooltip Prostaglandin D2 receptor 1
6290:COX-inhibiting nitric oxide donator
4823:from the original on 15 August 2022
4640:from the original on 28 August 2021
4288:"Vet drug 'killing Asian vultures'"
3595:
3212:The New England Journal of Medicine
2843:from the original on 4 October 2017
2570:
2349:from the original on 30 August 2024
1433:
1368:Major adverse cardiovascular events
1354:Nonsteroidal anti-inflammatory drug
1312:, as diclofenac may trigger attacks
961:nonsteroidal anti-inflammatory drug
593:
484:
27:Nonsteroidal anti-inflammatory drug
24:
10394:AM-404 (N-arachidonoylaminophenol)
10212:Anthranilic acids (fenamic acids):
9864:Mesalazine (5-aminosalicylic acid)
8955:Tooltip Prostaglandin EP4 receptor
8840:Tooltip Prostaglandin EP3 receptor
8763:Tooltip Prostaglandin EP2 receptor
8656:Tooltip Prostaglandin EP1 receptor
4853:from the original on 15 March 2023
4671:from the original on 23 April 2023
4521:Schwaiger J, Triebskorn R (2005).
3930:
3827:10.1523/JNEUROSCI.21-20-08026.2001
3764:
3577:from the original on 23 April 2023
3534:from the original on 23 April 2023
2940:(Press release). 15 October 2020.
2768:. 27 November 2013. Archived from
2555:from the original on 16 April 2022
2157:10.1016/b978-1-4377-2242-0.00026-2
1894:vulture populations were decimated
1347:
1046:, like other drugs in this class.
25:
11039:
10884:γ-Linolenic acid (gamolenic acid)
10230:Meclofenamic acid (meclofenamate)
8639:Tooltip Prostaglandin E2 receptor
8458:Tooltip Prostaglandin D2 receptor
8053:Tetrahydrocannabinol (dronabinol)
5095:Zinc pyrithione (pyrithione zinc)
4939:to help reach a consensus. ›
4918:
4849:(in Finnish). 10 September 2014.
4123:from the original on 2 April 2015
3254:. 4 December 2009. Archived from
2981:U.S. Food and Drug Administration
2634:10.1016/j.ijantimicag.2007.04.016
1949:"Diclofenac Use During Pregnancy"
1906:
1888:, as well as cellular damage and
1870:
1545:-inhibition. Diclofenac inhibits
1525:As with most NSAIDs, the primary
1145:Voltaren (diclofenac) 50 mg
280:
166:
10960:
10939:Leukotriene signaling modulators
10731:Tooltip Prostaglandin F synthase
10712:Tooltip Prostaglandin E synthase
10671:Tooltip Prostaglandin D synthase
9113:Tooltip Prostaglandin F receptor
6648:
6638:
6629:
6628:
4732:from the original on 13 May 2016
4414:from the original on 29 May 2014
3995:Informatics in Medicine Unlocked
3860:European Journal of Pharmacology
3788:10.1111/j.2042-7158.2012.01479.x
3703:The American Journal of Medicine
3668:The American Journal of Medicine
3633:The American Journal of Medicine
2997:
2954:
2810:10.1111/j.1526-4637.2010.00809.x
2520:from the original on 7 July 2022
2053:
1725:
1509:
1392:increased by diclofenac (1·65).
1209:
1193:
1173:
1154:
1138:
1034:. Use is not recommended in the
913:
869:
752:
746:
740:
86:
63:
54:
10250:Talinflumic acid (talinflumate)
10240:Morniflumic acid (morniflumate)
10220:Floctafenic acid (floctafenate)
10203:Tiaprofenic acid (tiaprofenate)
6540:Superoxide dismutase / orgotein
5055:Ciclopirox olamine (ciclopirox)
4835:
4804:
4786:Vulture Conservation Foundation
4774:
4744:
4652:
4585:
4514:
4470:
4426:
4395:
4186:
4105:
4048:
3982:
3851:
3802:
3729:
3624:
3589:
3546:
3431:
3372:
3342:
3238:
3188:10.1161/CIRCOUTCOMES.109.861104
3088:
3058:
2784:
2751:
2674:
2648:
2591:
2477:10.1016/j.scitotenv.2021.148851
2361:
2331:
2305:
2212:
1520:
1261:Active stomach and/or duodenal
1234:History of allergic reactions (
1180:Dyloject (diclofenac) 2 ml for
1063:
979:(swallowed by mouth), inserted
836:Key:DCOPUUMXTXDBNB-UHFFFAOYSA-N
362:Liver, oxidative, primarily by
10773:Tooltip Thromboxane A synthase
9824:Aspirin (acetylsalicylic acid)
9038:16,16-Dimethyl Prostaglandin E
7821:Aspirin (acetylsalicylic acid)
5852:Aspirin (acetylsalicylic acid)
4788:. 7 April 2021. Archived from
4690:Choudhary S (29 August 2016).
2727:10.1002/14651858.CD009781.pub2
2185:
2136:
2065:
1996:
1892:. In South Asia in the 2000s,
1623:Blockage of voltage-dependent
1231:Hypersensitivity to diclofenac
811:O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl
755:
734:
293:
13:
1:
10932:Receptor/signaling modulators
10754:Tooltip Prostacyclin synthase
10255:Tolfenamic acid (tolfenamate)
10225:Flufenamic acid (flufenamate)
10215:Etofenamic acid (etofenamate)
9271:Prostacyclin (prostaglandin I
9210:Tooltip Prostacyclin receptor
4924:
4500:10.1016/j.aquatox.2004.03.015
4456:10.1016/j.aquatox.2004.03.014
4032:Analogue-based drug discovery
3872:10.1016/S0014-2999(02)01288-8
3715:10.1016/S0002-9343(98)00091-6
3486:10.1016/S0924-8579(99)00159-4
3291:10.1016/S0885-3924(02)00370-6
2895:10.1016/S0140-6736(13)60900-9
2682:"Naclof, oogdruppels 1 mg/ml"
1899:
997:applied to the skin topically
955:), sold under the brand name
386:; no active metabolites exist
9338:Tooltip Thromboxane receptor
4370:10.1371/journal.pbio.0040066
4081:Connelly D (28 April 2017).
3680:10.1016/0002-9343(86)90077-x
3645:10.1016/0002-9343(86)90074-4
3610:10.1185/03007995.2010.486301
3444:National Library of Medicine
3251:Food and Drug Administration
2936:Food and Drug Administration
2040:Food and Drug Administration
1694:Formulations and brand names
1376:Food and Drug Administration
1036:third trimester of pregnancy
1010:Common side effects include
374:, as well as conjugative by
85:Cataflam, Voltaren, Zipsor,
7:
11023:Drugs developed by Novartis
10404:Paracetamol (acetaminophen)
10235:Mefenamic acid (mefenamate)
9889:Salicylate (salicylic acid)
7463:Paracetamol (acetaminophen)
5918:Salicylic acid (salicylate)
4811:Fernholm A (4 March 2010).
3815:The Journal of Neuroscience
3224:10.1056/NEJM200108093450607
2192:Sayyad M (23 August 2018).
2149:Essentials of Pain Medicine
1553:with relative equipotency.
1250:) to other NSAIDs, such as
1200:Sintofarm (diclofenac) for
1131:pain associated with cancer
1038:. It is likely safe during
39:Diachronic (disambiguation)
10:
11044:
10083:Bucloxic acid (blucloxate)
10001:Indometacin (indomethacin)
4659:Walker M (6 August 2008).
4256:10.1016/j.cbpc.2008.07.014
4087:The Pharmaceutical Journal
4034:. Wiley-VCH. p. 517.
3750:10.1016/j.bbrc.2006.06.034
2260:10.1177/102490790200900201
1768:
1656:
1480:Postmarketing surveillance
1448:150 mg at bedtime or
1374:In October 2020, the U.S.
1351:
1341:toxic epidermal necrolysis
1272:Inflammatory bowel disease
1124:traumatic corneal abrasion
724:Chemical and physical data
36:
29:
11028:Drugs developed by Pfizer
10923:
10868:
10766:
10743:
10724:
10705:
10660:
10245:Niflumic acid (niflumate)
9798:
9781:
9556:
9349:Carbocyclic thromboxane A
9327:
9199:
9102:
9027:
8945:
8830:
8753:
8646:
8628:
8522:
8465:
8447:
8430:
8347:
8266:
8223:
8201:
8164:Tricyclic antidepressants
8120:
8072:
8061:
8023:
7978:
7927:
7811:
7778:
7727:
7663:
7627:
7537:
7528:
7437:
7235:
7053:
6994:
6985:
6910:
6891:
6791:
6761:
6728:
6715:
6624:
6601:
6553:
6472:
6390:
6303:
6139:
6084:
5931:
5841:
5731:
5487:
5421:
5388:Potassium channel openers
5314:
5262:
5239:
5211:
4994:
4891:10.1080/03079450802056439
4563:10.1007/s00216-006-1033-x
4402:Phadnis M (28 May 2014).
4008:10.1016/j.imu.2023.101159
3958:10.1007/s40265-015-0392-z
3446:(published 22 May 2023).
3350:"Diclofenac Side Effects"
3328:10.1038/nature.2016.19839
3034:10.1136/bmj.332.7553.1302
2764:World Health Organization
2543:McKie R (11 April 2021).
1630:Blockage of acid-sensing
1491:
1343:(TEN), which can be fatal
1267:gastrointestinal bleeding
1257:Third-trimester pregnancy
1216:150 gram tube diclofenac
1016:gastrointestinal bleeding
844:
819:
799:
777:
764:
728:
723:
704:
672:
644:
624:
604:
584:
564:
544:
524:
504:
479:
459:
439:
434:
417:
400:
390:
356:
346:
338:
270:
265:
210:
180:
154:
124:
110:
92:
79:
74:
62:
53:
10563:Menatetrenone (vitamin K
10386:Aminophenols (anilines):
7498:+propyphenazone/caffeine
6588:Naproxen/diphenhydramine
4937:templates for discussion
3510:Sandri A (August 2014).
3406:10.1073/pnas.90.24.11693
3272:Brater DC (April 2002).
3128:Arthritis and Rheumatism
2513:, EMA/CVMP/761582/2014,
2219:O'Toole MT, ed. (2017).
1849:dispose of human corpses
1456:
1386:
1337:Stevens–Johnson syndrome
1286:congestive heart failure
10889:Dihomo-γ-linolenic acid
10286:Enolic acids (oxicams):
9829:Benorilate (benorylate)
6609:WHO-Essential Medicines
5585:Glycopyrronium tosylate
5500:Aminobenzoate potassium
5432:5α-Reductase inhibitors
5380:Topilutamide (fluridil)
5325:5α-Reductase inhibitors
5300:Topical corticosteroids
5197:Topical corticosteroids
1589:). It also may inhibit
1585:(also pro-inflammatory
1452:20 mg at bedtime).
328:Rx-only / OTC
10688:selenium tetrachloride
7348:Pethidine (meperidine)
5937:and related substances
5580:Glycopyrronium bromide
5423:Hair growth inhibitors
5110:Calcineurin inhibitors
4756:International BirdLife
4211:10.1098/rsbl.2005.0425
3553:Sandri A (June 2016).
2833:"Diclofenac Potassium"
2416:10.1098/rstb.2013.0574
1736:is missing information
1333:exfoliative dermatitis
1303:chronic kidney disease
1089:inflammatory disorders
1068:Diclofenac is used to
963:(NSAID) used to treat
10357:Aminonicotinic acids:
7969:+paracetamol/caffeine
7947:Metamizole (dipyrone)
7881:Morpholine salicylate
7825:+paracetamol/caffeine
6593:Naproxen/esomeprazole
6583:Meloxicam/bupivacaine
6578:Ibuprofen/paracetamol
6568:Ibuprofen/hydrocodone
5169:urea-containing cream
4068:24 April 2023 at the
2339:"The Top 300 of 2022"
1771:Indian vulture crisis
1058:Indian vulture crisis
969:inflammatory diseases
959:, among others, is a
10006:Indometacin farnesil
9859:Magnesium salicylate
9490:Pinane thromboxane A
9251:Iloprost (ciloprost)
8871:Iloprost (ciloprost)
8677:Iloprost (ciloprost)
8092:Gabapentin enacarbil
7886:Potassium salicylate
7876:Magnesium salicylate
7871:Imidazole salicylate
7698:Indometacin farnesil
7094:Diamorphine (heroin)
7061:Acetyldihydrocodeine
6563:Ibuprofen/famotidine
6021:Indometacin farnesil
5893:Magnesium salicylate
5714:(NSAIDs) (primarily
5645:Pregnenolone acetate
5346:Saw palmetto extract
4294:. 28 February 2004.
1529:responsible for its
1220:U.S. package generic
1168:) 50 mg tablets
9834:Carbasalate calcium
7841:Carbasalate calcium
6573:Ibuprofen/oxycodone
6490:Chondroitin sulfate
5868:Carbasalate calcium
5462:Cyproterone acetate
5365:Cyproterone acetate
5316:Alopecia treatments
5264:Anti-inflammatories
5045:Cetrimonium bromide
5016:Cyproterone acetate
4726:European Parliament
4610:2008EnvTC..27.2341R
4492:2004AqTox..68..151T
4448:2004AqTox..68..141S
4164:10.1038/nature02317
4156:2004Natur.427..630O
3397:1993PNAS...9011693M
3391:(24): 11693–11697.
3102:. 14 January 2015.
3028:(7553): 1302–1308.
2469:2021ScTEn.79648851M
1877:veterinary medicine
1791:use of diclofenac.
1689:Society and culture
1568:blood-brain barrier
1378:(FDA) required the
50:
10696:selenium disulfide
10328:4-Aminoquinolines:
8374:Never to phase III
8279:Analgesic adjuvant
8180:1.7/1.8-selective:
7846:Choline salicylate
7273:Dextropropoxyphene
6918:Dimethyl sulfoxide
6480:Aminopropionitrile
4696:The Indian Express
4480:Aquatic Toxicology
4436:Aquatic Toxicology
4030:Fischer J (2006).
3908:10.1007/BF01037953
2410:(1656): 20130574.
2043:. 14 February 2020
1875:Though its use in
1804:New World vultures
1717:Ecological effects
1639:potassium channels
1280:ulcerative colitis
1085:rheumatic diseases
1032:stomach ulceration
975:. It can be taken
46:
10948:
10947:
10864:
10863:
9899:Sodium salicylate
9869:Methyl salicylate
9792:
9777:
9776:
9098:
9097:
8624:
8623:
8441:
8384:
8383:
8219:
8218:
8203:Potassium openers
8140:Local anesthetics
8082:Alcohol (ethanol)
8019:
8018:
7918:methyl salicylate
7906:Sodium salicylate
7793:Meclofenamic acid
7468:+aspirin/caffeine
7433:
7432:
6936:
6935:
6887:
6886:
6849:Meclofenamic acid
6717:Anti-inflammatory
6662:
6661:
6510:Glycosaminoglycan
6360:Meclofenamic acid
5923:Sodium salicylate
5898:Methyl salicylate
5678:
5677:
5615:Magnesium sulfate
5595:Hydrogen peroxide
5530:Calcium gluconate
5189:Lithium succinate
5184:Lithium gluconate
5080:Piroctone olamine
4817:LäkemedelsVärlden
4604:(11): 2341–2345.
4150:(6975): 630–633.
4041:978-3-527-31257-3
3821:(20): 8026–8033.
3782:(10): 1359–1375.
3258:on 29 March 2015.
3140:10.1002/art.21887
2889:(9894): 769–779.
2689:Laboratoires THEA
2324:978-0-323-56682-7
2298:978-0-85711-298-9
2232:978-0-323-22205-1
2200:on 24 August 2018
2166:978-1-4377-2242-0
1955:. 16 January 2000
1861:cinereous vulture
1853:Towers of Silence
1767:
1766:
1531:anti-inflammatory
1310:hepatic porphyria
1226:Contraindications
1112:actinic keratosis
862:
861:
790:Interactive image
674:CompTox Dashboard
321:
308:
296:
284:
170:
137:
16:(Redirected from
11035:
10965:
10964:
10963:
10956:
10899:Arachidonic acid
10774:
10770:
10755:
10751:
10732:
10728:
10713:
10709:
10672:
10668:
10495:Others/unsorted:
10070:Propionic acids:
10051:Sulindac sulfide
9816:Salicylic acids:
9807:
9802:
9796:
9795:
9786:
9339:
9335:
9211:
9207:
9114:
9110:
8956:
8952:
8841:
8837:
8764:
8760:
8657:
8653:
8644:
8643:
8640:
8636:
8533:
8529:
8476:
8472:
8463:
8462:
8459:
8455:
8445:
8444:
8435:
8411:
8404:
8397:
8388:
8387:
8074:Calcium blockers
8070:
8069:
7966:
7915:
7741:
7729:COX-2 inhibitors
7695:
7614:Tiaprofenic acid
7585:
7572:
7564:
7535:
7534:
7412:
7192:
7131:
7103:
7075:
6992:
6991:
6963:
6956:
6949:
6940:
6939:
6726:
6725:
6689:
6682:
6675:
6666:
6665:
6652:
6642:
6641:
6632:
6631:
6392:COX-2 inhibitors
6307:-arylanthranilic
6274:Tiaprofenic acid
5705:
5698:
5691:
5682:
5681:
5555:Deoxycholic acid
5545:Cromoglicic acid
4996:Anti-seborrheics
4975:
4968:
4961:
4952:
4951:
4912:
4911:
4893:
4869:
4863:
4862:
4860:
4858:
4839:
4833:
4832:
4830:
4828:
4808:
4802:
4801:
4799:
4797:
4778:
4772:
4771:
4769:
4767:
4762:on 24 April 2014
4758:. Archived from
4748:
4742:
4741:
4739:
4737:
4718:
4712:
4711:
4709:
4707:
4687:
4681:
4680:
4678:
4676:
4656:
4650:
4649:
4647:
4645:
4618:10.1897/08-123.1
4589:
4583:
4582:
4557:(4): 1405–1416.
4545:
4539:
4538:
4528:
4518:
4512:
4511:
4474:
4468:
4467:
4430:
4424:
4423:
4421:
4419:
4399:
4393:
4392:
4382:
4372:
4348:
4337:
4336:
4334:
4332:
4317:
4308:
4307:
4305:
4303:
4284:
4278:
4277:
4267:
4239:
4233:
4232:
4222:
4190:
4184:
4183:
4139:
4133:
4132:
4130:
4128:
4109:
4103:
4102:
4100:
4098:
4078:
4072:
4064:
4063:
4059:
4052:
4046:
4045:
4027:
4021:
4020:
4010:
3986:
3980:
3979:
3969:
3937:
3928:
3927:
3890:
3884:
3883:
3855:
3849:
3848:
3838:
3806:
3800:
3799:
3771:
3762:
3761:
3744:(4): 1275–1283.
3733:
3727:
3726:
3698:
3692:
3691:
3663:
3657:
3656:
3628:
3622:
3621:
3604:(7): 1715–1731.
3593:
3587:
3586:
3584:
3582:
3550:
3544:
3543:
3541:
3539:
3507:
3498:
3497:
3469:
3463:
3462:
3460:
3458:
3435:
3429:
3428:
3418:
3408:
3376:
3370:
3369:
3367:
3365:
3346:
3340:
3339:
3315:
3304:
3303:
3293:
3269:
3260:
3259:
3242:
3236:
3235:
3207:
3201:
3200:
3190:
3166:
3160:
3159:
3134:(5): 1378–1389.
3122:
3116:
3115:
3113:
3111:
3092:
3086:
3085:
3083:
3081:
3072:. 29 June 2013.
3062:
3056:
3055:
3045:
3013:
3007:
3001:
3000:
2996:
2994:
2992:
2983:. 21 July 2017.
2973:
2964:
2958:
2957:
2953:
2951:
2949:
2926:
2917:
2916:
2906:
2874:
2853:
2852:
2850:
2848:
2829:
2823:
2822:
2812:
2788:
2782:
2781:
2779:
2777:
2772:on 7 August 2003
2755:
2749:
2748:
2738:
2706:
2700:
2699:
2697:
2686:
2678:
2672:
2671:
2652:
2646:
2645:
2617:
2611:
2610:
2595:
2589:
2588:
2577:
2568:
2567:
2562:
2560:
2540:
2529:
2528:
2527:
2525:
2519:
2512:
2500:
2489:
2488:
2451:
2438:
2437:
2427:
2395:
2384:
2383:
2381:
2379:
2365:
2359:
2358:
2356:
2354:
2335:
2329:
2328:
2309:
2303:
2302:
2285:
2272:
2271:
2243:
2237:
2236:
2216:
2210:
2209:
2207:
2205:
2189:
2183:
2182:
2180:
2178:
2140:
2134:
2133:
2131:
2129:
2113:
2088:
2087:
2085:
2083:
2069:
2063:
2057:
2056:
2052:
2050:
2048:
2031:
2022:
2021:
2019:
2017:
2000:
1994:
1993:
1991:
1989:
1979:nctr-crs.fda.gov
1971:
1965:
1964:
1962:
1960:
1945:
1939:
1938:
1936:
1934:
1915:
1762:
1759:
1753:
1729:
1721:
1602:COX-2 inhibitors
1591:phospholipase A2
1483:transplantation.
1434:Gastrointestinal
1213:
1197:
1177:
1164:(diclofenac and
1158:
1142:
1052:
954:
953:
950:
949:
946:
943:
940:
937:
934:
931:
928:
925:
922:
919:
910:
909:
906:
905:
902:
899:
896:
893:
890:
887:
884:
881:
878:
875:
858:
857:
850:
792:
772:
757:
754:
748:
742:
736:
719:
708:
697:
696:
682:
680:
664:
658:
637:
617:
597:
577:
557:
537:
517:
497:
487:
486:
472:
405:
326:
319:
316:
306:
303:
295:
292:
282:
279:
257:
247:
237:
227:
168:
165:
147:
136:
133:
120:
106:
67:
58:
51:
49:
45:
21:
11043:
11042:
11038:
11037:
11036:
11034:
11033:
11032:
10973:
10972:
10971:
10961:
10959:
10951:
10949:
10944:
10919:
10915:
10912:Prostaglandin H
10907:
10904:Prostaglandin G
10860:
10772:
10762:
10760:Tranylcypromine
10753:
10749:
10739:
10730:
10720:
10711:
10701:
10692:sodium selenite
10670:
10666:
10656:
10602:Rosmarinic acid
10566:
10374:Sulfonanilides:
10277:Oxyphenbutazone
9803:
9785:
9773:
9552:
9493:
9365:
9352:
9337:
9333:
9323:
9283:
9280:Prostaglandin E
9275:, epoprostenol)
9274:
9209:
9205:
9195:
9170:
9167:Prostaglandin F
9162:
9159:Prostaglandin D
9112:
9108:
9094:
9079:
9076:Prostaglandin F
9041:
9023:
8988:
8985:Prostaglandin E
8979:
8976:Prostaglandin E
8954:
8951:
8941:
8922:Ricinoleic acid
8911:
8908:Prostaglandin E
8902:
8899:Prostaglandin E
8894:
8891:Prostaglandin D
8839:
8836:
8826:
8796:
8793:Prostaglandin E
8787:
8784:Prostaglandin E
8762:
8759:
8749:
8709:
8706:Prostaglandin E
8700:
8697:Prostaglandin E
8655:
8652:
8638:
8634:
8620:
8551:
8548:Prostaglandin D
8531:
8528:
8518:
8489:
8486:Prostaglandin D
8474:
8471:
8457:
8453:
8434:
8426:
8415:
8385:
8380:
8379:
8364:Clinical trials
8343:
8324:Phenazopyridine
8262:
8243:Cyclobenzaprine
8215:
8197:
8179:
8122:Sodium blockers
8116:
8064:
8057:
8015:
7974:
7964:
7923:
7913:
7807:
7803:Tolfenamic acid
7788:Flufenamic acid
7774:
7739:
7723:
7693:
7659:
7623:
7583:
7570:
7562:
7524:
7488:+metoclopramide
7429:
7410:
7231:
7190:
7129:
7112:Dihydromorphine
7101:
7073:
7049:
6981:
6967:
6937:
6932:
6906:
6883:
6787:
6765:
6757:
6748:Oxyphenbutazone
6720:
6718:
6711:
6693:
6663:
6658:
6620:
6613:withdrawn drugs
6597:
6555:
6549:
6468:
6394:
6386:
6382:Tolfenamic acid
6340:Flufenamic acid
6308:
6299:
6143:
6135:
6080:
5936:
5927:
5837:
5806:Oxyphenbutazone
5736:
5727:
5709:
5679:
5674:
5640:Povidone-iodine
5590:Hyaluronic acid
5515:Benzoylperoxide
5483:
5417:
5310:
5258:
5235:
5213:Skin lightening
5207:
4990:
4979:
4940:
4921:
4916:
4915:
4878:Avian Pathology
4870:
4866:
4856:
4854:
4841:
4840:
4836:
4826:
4824:
4809:
4805:
4795:
4793:
4792:on 8 April 2021
4780:
4779:
4775:
4765:
4763:
4750:
4749:
4745:
4735:
4733:
4720:
4719:
4715:
4705:
4703:
4688:
4684:
4674:
4672:
4657:
4653:
4643:
4641:
4590:
4586:
4546:
4542:
4526:
4519:
4515:
4475:
4471:
4431:
4427:
4417:
4415:
4400:
4396:
4349:
4340:
4330:
4328:
4319:
4318:
4311:
4301:
4299:
4286:
4285:
4281:
4240:
4236:
4199:Biology Letters
4191:
4187:
4140:
4136:
4126:
4124:
4111:
4110:
4106:
4096:
4094:
4079:
4075:
4070:Wayback Machine
4061:
4053:
4049:
4042:
4028:
4024:
3987:
3983:
3938:
3931:
3891:
3887:
3856:
3852:
3807:
3803:
3772:
3765:
3734:
3730:
3699:
3695:
3664:
3660:
3629:
3625:
3594:
3590:
3580:
3578:
3551:
3547:
3537:
3535:
3508:
3501:
3470:
3466:
3456:
3454:
3436:
3432:
3377:
3373:
3363:
3361:
3348:
3347:
3343:
3316:
3307:
3270:
3263:
3244:
3243:
3239:
3208:
3204:
3167:
3163:
3123:
3119:
3109:
3107:
3094:
3093:
3089:
3079:
3077:
3064:
3063:
3059:
3014:
3010:
2998:
2990:
2988:
2975:
2974:
2967:
2955:
2947:
2945:
2928:
2927:
2920:
2875:
2856:
2846:
2844:
2831:
2830:
2826:
2789:
2785:
2775:
2773:
2757:
2756:
2752:
2721:(5): CD009781.
2707:
2703:
2695:
2684:
2680:
2679:
2675:
2654:
2653:
2649:
2618:
2614:
2597:
2596:
2592:
2587:on 26 May 2011.
2579:
2578:
2571:
2558:
2556:
2541:
2532:
2523:
2521:
2517:
2510:
2501:
2492:
2452:
2441:
2396:
2387:
2377:
2375:
2367:
2366:
2362:
2352:
2350:
2337:
2336:
2332:
2325:
2311:
2310:
2306:
2299:
2287:
2286:
2275:
2244:
2240:
2233:
2217:
2213:
2203:
2201:
2190:
2186:
2176:
2174:
2167:
2141:
2137:
2127:
2125:
2115:
2114:
2091:
2081:
2079:
2071:
2070:
2066:
2054:
2046:
2044:
2033:
2032:
2025:
2015:
2013:
2002:
2001:
1997:
1987:
1985:
1973:
1972:
1968:
1958:
1956:
1947:
1946:
1942:
1932:
1930:
1917:
1916:
1907:
1902:
1873:
1845:Parsi community
1773:
1763:
1757:
1754:
1747:
1730:
1719:
1708:nonprescription
1696:
1691:
1679:GlaxoSmithKline
1659:
1651:synovial fluids
1625:sodium channels
1606:adverse effects
1558:cycloxygenase-2
1523:
1512:
1494:
1459:
1436:
1397:COX-2 inhibitor
1389:
1356:
1350:
1348:Adverse effects
1276:Crohn's disease
1228:
1221:
1214:
1205:
1198:
1189:
1178:
1169:
1159:
1150:
1143:
1066:
1050:
1028:kidney problems
991:(IM), injected
989:intramuscularly
916:
912:
872:
868:
853:
851:
848:(what is this?)
845:
840:
837:
832:
827:
826:
815:
812:
807:
806:
795:
770:
760:
751:
745:
739:
700:
676:
668:
640:
620:
600:
580:
560:
540:
520:
500:
483:
475:
455:
452:
447:
446:
403:
392:Onset of action
376:glucuronidation
348:Protein binding
340:Pharmacokinetic
334:
324:
261:
183:
176:
157:
150:
70:
42:
35:
32:Dichloromethane
28:
23:
22:
15:
12:
11:
5:
11041:
11031:
11030:
11025:
11020:
11015:
11010:
11005:
11000:
10995:
10990:
10985:
10970:
10969:
10946:
10945:
10943:
10942:
10935:
10928:
10924:
10921:
10920:
10918:
10917:
10913:
10909:
10905:
10901:
10896:
10894:Diacylglycerol
10891:
10886:
10881:
10872:
10870:
10866:
10865:
10862:
10861:
10859:
10858:
10853:
10848:
10843:
10838:
10833:
10828:
10823:
10818:
10813:
10808:
10803:
10798:
10793:
10788:
10783:
10777:
10775:
10764:
10763:
10758:
10756:
10747:
10741:
10740:
10735:
10733:
10722:
10721:
10716:
10714:
10703:
10702:
10700:
10699:
10681:
10675:
10673:
10664:
10658:
10657:
10655:
10654:
10649:
10644:
10639:
10634:
10629:
10624:
10619:
10614:
10609:
10604:
10599:
10594:
10589:
10584:
10579:
10574:
10569:
10564:
10560:
10555:
10550:
10545:
10540:
10535:
10530:
10525:
10520:
10515:
10510:
10505:
10500:
10488:
10483:
10478:
10473:
10468:
10463:
10458:
10453:
10448:
10443:
10438:
10433:
10428:
10416:
10411:
10406:
10401:
10396:
10391:
10379:
10367:
10362:
10350:
10338:
10333:
10321:
10316:
10311:
10306:
10301:
10296:
10291:
10282:Phenylbutazone
10279:
10274:
10269:
10264:
10252:
10247:
10242:
10237:
10232:
10227:
10222:
10217:
10205:
10200:
10195:
10190:
10185:
10180:
10175:
10170:
10165:
10160:
10155:
10150:
10145:
10140:
10135:
10130:
10125:
10120:
10115:
10110:
10105:
10100:
10095:
10090:
10085:
10080:
10075:
10063:
10058:
10053:
10048:
10043:
10038:
10033:
10028:
10023:
10018:
10013:
10008:
10003:
9998:
9993:
9988:
9983:
9978:
9973:
9968:
9963:
9958:
9953:
9948:
9943:
9938:
9933:
9928:
9923:
9918:
9913:
9901:
9896:
9891:
9886:
9881:
9876:
9871:
9866:
9861:
9856:
9851:
9846:
9841:
9836:
9831:
9826:
9821:
9812:
9810:
9793:
9779:
9778:
9775:
9774:
9772:
9771:
9766:
9761:
9756:
9751:
9746:
9741:
9736:
9731:
9726:
9721:
9716:
9711:
9706:
9701:
9696:
9691:
9686:
9681:
9676:
9671:
9666:
9661:
9656:
9651:
9646:
9641:
9636:
9631:
9626:
9621:
9616:
9611:
9606:
9601:
9596:
9591:
9586:
9581:
9576:
9571:
9566:
9560:
9558:
9554:
9553:
9551:
9550:
9545:
9540:
9535:
9530:
9525:
9520:
9515:
9510:
9505:
9500:
9495:
9491:
9487:
9482:
9477:
9472:
9467:
9462:
9457:
9452:
9447:
9442:
9437:
9432:
9427:
9422:
9417:
9412:
9407:
9402:
9397:
9392:
9387:
9378:
9377:
9372:
9367:
9363:
9359:
9354:
9350:
9342:
9340:
9331:
9325:
9324:
9322:
9321:
9312:
9311:
9306:
9301:
9296:
9291:
9286:
9281:
9277:
9272:
9268:
9263:
9258:
9256:Isocarbacyclin
9253:
9248:
9243:
9238:
9233:
9228:
9223:
9214:
9212:
9203:
9197:
9196:
9194:
9193:
9188:
9183:
9178:
9173:
9168:
9164:
9160:
9156:
9151:
9146:
9141:
9136:
9131:
9126:
9117:
9115:
9106:
9100:
9099:
9096:
9095:
9093:
9092:
9087:
9082:
9077:
9073:
9068:
9063:
9058:
9053:
9048:
9043:
9039:
9031:
9029:
9025:
9024:
9022:
9021:
9016:
9011:
9006:
8997:
8996:
8991:
8989:(dinoprostone)
8986:
8982:
8977:
8973:
8968:
8959:
8957:
8949:
8943:
8942:
8940:
8939:
8930:
8929:
8924:
8919:
8914:
8912:(dinoprostone)
8909:
8905:
8900:
8896:
8892:
8888:
8883:
8878:
8876:Isocarbacyclin
8873:
8868:
8863:
8858:
8853:
8844:
8842:
8834:
8828:
8827:
8825:
8824:
8819:
8814:
8805:
8804:
8799:
8797:(dinoprostone)
8794:
8790:
8785:
8781:
8776:
8767:
8765:
8757:
8751:
8750:
8748:
8747:
8742:
8737:
8732:
8727:
8718:
8717:
8712:
8710:(dinoprostone)
8707:
8703:
8698:
8694:
8689:
8684:
8679:
8674:
8669:
8660:
8658:
8650:
8641:
8632:
8626:
8625:
8622:
8621:
8619:
8618:
8613:
8608:
8603:
8598:
8593:
8588:
8583:
8578:
8573:
8568:
8563:
8554:
8553:
8549:
8545:
8536:
8534:
8526:
8520:
8519:
8517:
8516:
8511:
8506:
8497:
8496:
8491:
8487:
8479:
8477:
8469:
8460:
8451:
8442:
8428:
8427:
8414:
8413:
8406:
8399:
8391:
8382:
8381:
8378:
8377:
8376:
8375:
8372:
8361:
8355:
8349:
8348:
8345:
8344:
8342:
8341:
8336:
8331:
8326:
8321:
8319:Methoxyflurane
8316:
8311:
8306:
8301:
8296:
8291:
8286:
8281:
8276:
8270:
8268:
8264:
8263:
8261:
8260:
8255:
8250:
8245:
8240:
8235:
8229:
8227:
8221:
8220:
8217:
8216:
8214:
8213:
8207:
8205:
8199:
8198:
8196:
8195:
8190:
8185:
8177:
8172:
8171:
8161:
8156:
8151:
8137:
8132:
8126:
8124:
8118:
8117:
8115:
8114:
8109:
8104:
8099:
8094:
8089:
8084:
8078:
8076:
8067:
8059:
8058:
8056:
8055:
8050:
8045:
8040:
8035:
8029:
8027:
8021:
8020:
8017:
8016:
8014:
8013:
8008:
8003:
7998:
7993:
7988:
7982:
7980:
7976:
7975:
7973:
7972:
7962:Propyphenazone
7959:
7954:
7949:
7944:
7939:
7937:Aminophenazone
7933:
7931:
7925:
7924:
7922:
7921:
7908:
7903:
7898:
7893:
7888:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7848:
7843:
7838:
7833:
7828:
7817:
7815:
7809:
7808:
7806:
7805:
7800:
7798:Mefenamic acid
7795:
7790:
7784:
7782:
7776:
7775:
7773:
7772:
7767:
7762:
7757:
7752:
7747:
7733:
7731:
7725:
7724:
7722:
7721:
7716:
7711:
7706:
7701:
7688:
7683:
7678:
7673:
7667:
7665:
7661:
7660:
7658:
7657:
7652:
7647:
7642:
7637:
7631:
7629:
7625:
7624:
7622:
7621:
7616:
7611:
7606:
7601:
7596:
7591:
7578:
7557:
7552:
7547:
7541:
7539:
7532:
7526:
7525:
7523:
7522:
7517:
7512:
7507:
7506:
7505:
7500:
7495:
7490:
7485:
7480:
7475:
7470:
7460:
7455:
7450:
7444:
7442:
7435:
7434:
7431:
7430:
7428:
7427:
7422:
7405:
7400:
7395:
7390:
7385:
7380:
7375:
7370:
7365:
7360:
7355:
7350:
7345:
7340:
7335:
7330:
7325:
7320:
7315:
7310:
7305:
7295:
7290:
7285:
7280:
7275:
7270:
7268:Dextromoramide
7265:
7260:
7255:
7250:
7245:
7239:
7237:
7233:
7232:
7230:
7229:
7224:
7219:
7214:
7185:
7180:
7175:
7170:
7165:
7160:
7155:
7150:
7148:Hydromorphinol
7145:
7124:
7119:
7114:
7109:
7099:Dihydrocodeine
7096:
7091:
7086:
7081:
7068:
7066:Benzylmorphine
7063:
7057:
7055:
7051:
7050:
7048:
7047:
7042:
7037:
7032:
7022:
7021:
7020:
7015:
7004:
7002:
6989:
6983:
6982:
6966:
6965:
6958:
6951:
6943:
6934:
6933:
6931:
6930:
6925:
6920:
6914:
6912:
6908:
6907:
6905:
6904:
6898:
6896:
6889:
6888:
6885:
6884:
6882:
6881:
6876:
6871:
6866:
6861:
6856:
6851:
6846:
6841:
6836:
6831:
6826:
6821:
6816:
6811:
6806:
6801:
6795:
6793:
6789:
6788:
6786:
6785:
6780:
6775:
6769:
6767:
6759:
6758:
6756:
6755:
6753:Phenylbutazone
6750:
6745:
6740:
6734:
6732:
6723:
6713:
6712:
6692:
6691:
6684:
6677:
6669:
6660:
6659:
6657:
6656:
6646:
6636:
6625:
6622:
6621:
6617:veterinary use
6602:
6599:
6598:
6596:
6595:
6590:
6585:
6580:
6575:
6570:
6565:
6559:
6557:
6551:
6550:
6548:
6547:
6542:
6537:
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6476:
6474:
6470:
6469:
6467:
6466:
6461:
6456:
6451:
6446:
6441:
6436:
6431:
6426:
6421:
6416:
6404:
6398:
6396:
6388:
6387:
6385:
6384:
6379:
6374:
6369:
6366:Mefenamic acid
6362:
6357:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6316:
6314:
6301:
6300:
6298:
6297:
6286:
6281:
6276:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6229:
6224:
6219:
6214:
6209:
6204:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6157:
6151:
6149:
6141:propionic acid
6137:
6136:
6134:
6133:
6128:
6123:
6116:
6111:
6106:
6101:
6096:
6090:
6088:
6082:
6081:
6079:
6078:
6073:
6068:
6063:
6058:
6053:
6048:
6043:
6038:
6033:
6028:
6023:
6018:
6013:
6008:
6006:Fenclozic acid
6003:
5998:
5993:
5988:
5981:
5976:
5971:
5966:
5961:
5956:
5951:
5946:
5940:
5938:
5929:
5928:
5926:
5925:
5920:
5915:
5910:
5905:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5855:
5847:
5845:
5839:
5838:
5836:
5835:
5830:
5828:Sulfinpyrazone
5825:
5823:Propyphenazone
5820:
5817:Phenylbutazone
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5746:Aminophenazone
5742:
5740:
5729:
5728:
5708:
5707:
5700:
5693:
5685:
5676:
5675:
5673:
5672:
5667:
5662:
5657:
5647:
5642:
5637:
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5567:
5562:
5557:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5512:
5502:
5497:
5491:
5489:
5485:
5484:
5482:
5481:
5476:
5475:
5474:
5472:Spironolactone
5469:
5464:
5459:
5447:
5446:
5445:
5440:
5427:
5425:
5419:
5418:
5416:
5415:
5414:
5413:
5408:
5398:
5397:
5396:
5384:
5383:
5382:
5377:
5375:Spironolactone
5372:
5367:
5362:
5350:
5349:
5348:
5343:
5338:
5333:
5320:
5318:
5312:
5311:
5309:
5308:
5305:hydrocortisone
5295:
5294:
5289:
5284:
5279:
5277:Gamolenic acid
5274:
5268:
5266:
5260:
5259:
5257:
5256:
5251:
5245:
5243:
5241:Skin darkening
5237:
5236:
5234:
5233:
5228:
5223:
5217:
5215:
5209:
5208:
5206:
5205:
5202:hydrocortisone
5193:
5192:
5191:
5186:
5174:
5173:
5172:
5162:
5157:
5155:Salicylic acid
5152:
5147:
5135:
5130:
5129:
5128:
5123:
5118:
5106:
5103:Antihistamines
5099:
5098:
5097:
5092:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5042:
5030:
5029:
5028:
5026:Spironolactone
5023:
5018:
5013:
5000:
4998:
4992:
4991:
4985:preparations (
4983:dermatological
4978:
4977:
4970:
4963:
4955:
4949:
4948:
4920:
4919:External links
4917:
4914:
4913:
4884:(3): 315–321.
4864:
4834:
4819:(in Swedish).
4803:
4773:
4743:
4713:
4682:
4651:
4584:
4540:
4513:
4486:(2): 151–166.
4469:
4442:(2): 141–150.
4425:
4394:
4338:
4309:
4279:
4250:(3): 269–274.
4234:
4205:(2): 279–282.
4185:
4134:
4104:
4073:
4047:
4040:
4022:
3981:
3952:(8): 859–877.
3929:
3902:(3): 389–394.
3885:
3866:(1–2): 85–91.
3850:
3801:
3763:
3728:
3709:(5): 413–421.
3693:
3658:
3623:
3588:
3565:(3): 167–172.
3559:Minerva Medica
3545:
3522:(4): 313–318.
3516:Minerva Medica
3499:
3480:(3): 249–251.
3464:
3430:
3371:
3341:
3305:
3261:
3237:
3218:(6): 433–442.
3202:
3181:(4): 395–405.
3161:
3117:
3087:
3057:
3008:
2965:
2918:
2854:
2824:
2803:(4): 535–549.
2783:
2750:
2701:
2673:
2660:MayoClinic.com
2647:
2628:(4): 336–340.
2612:
2590:
2569:
2530:
2490:
2439:
2385:
2360:
2330:
2323:
2304:
2297:
2273:
2238:
2231:
2211:
2184:
2165:
2135:
2089:
2064:
2023:
1995:
1966:
1940:
1904:
1903:
1901:
1898:
1872:
1871:Veterinary use
1869:
1808:turkey vulture
1806:, such as the
1784:kidney failure
1769:Main article:
1765:
1764:
1733:
1731:
1724:
1718:
1715:
1695:
1692:
1690:
1687:
1658:
1655:
1643:
1642:
1635:
1628:
1522:
1519:
1518:
1517:
1511:
1508:
1507:
1506:
1502:
1499:prostaglandins
1493:
1490:
1489:
1488:
1484:
1476:
1472:
1468:osteoarthritis
1458:
1455:
1454:
1453:
1435:
1432:
1388:
1385:
1349:
1346:
1345:
1344:
1329:
1326:
1323:
1316:
1313:
1306:
1299:
1296:
1293:
1282:
1269:
1259:
1254:
1232:
1227:
1224:
1223:
1222:
1215:
1208:
1206:
1204:administration
1199:
1192:
1190:
1188:administration
1179:
1172:
1170:
1160:
1153:
1151:
1147:enteric coated
1144:
1137:
1108:osteoarthritis
1065:
1062:
1044:prostaglandins
1012:abdominal pain
860:
859:
842:
841:
839:
838:
835:
833:
830:
822:
821:
820:
817:
816:
814:
813:
810:
802:
801:
800:
797:
796:
794:
793:
785:
783:
775:
774:
768:
762:
761:
758:
749:
743:
737:
732:
726:
725:
721:
720:
710:
702:
701:
699:
698:
685:
683:
670:
669:
667:
666:
650:
648:
642:
641:
639:
638:
630:
628:
622:
621:
619:
618:
610:
608:
602:
601:
599:
598:
590:
588:
582:
581:
579:
578:
570:
568:
562:
561:
559:
558:
550:
548:
542:
541:
539:
538:
530:
528:
522:
521:
519:
518:
510:
508:
502:
501:
499:
498:
490:
488:
477:
476:
474:
473:
465:
463:
457:
456:
454:
453:
450:
442:
441:
440:
437:
436:
432:
431:
421:
415:
414:
407:
398:
397:
394:
388:
387:
360:
354:
353:
350:
344:
343:
336:
335:
333:
332:
329:
314:
301:
290:
276:
274:
268:
267:
263:
262:
260:
259:
216:
214:
208:
207:
186:
184:administration
178:
177:
175:
174:
172:
162:
160:
152:
151:
149:
148:
130:
128:
122:
121:
114:
108:
107:
100:
90:
89:
83:
77:
76:
72:
71:
68:
60:
59:
26:
9:
6:
4:
3:
2:
11040:
11029:
11026:
11024:
11021:
11019:
11016:
11014:
11011:
11009:
11006:
11004:
11001:
10999:
10996:
10994:
10991:
10989:
10986:
10984:
10981:
10980:
10978:
10968:
10958:
10957:
10954:
10941:
10940:
10936:
10934:
10933:
10929:
10926:
10925:
10922:
10916:
10910:
10908:
10902:
10900:
10897:
10895:
10892:
10890:
10887:
10885:
10882:
10880:
10879:Linoleic acid
10877:
10874:
10873:
10871:
10867:
10857:
10854:
10852:
10849:
10847:
10844:
10842:
10839:
10837:
10834:
10832:
10829:
10827:
10824:
10822:
10819:
10817:
10814:
10812:
10809:
10807:
10804:
10802:
10799:
10797:
10794:
10792:
10789:
10787:
10784:
10782:
10779:
10778:
10776:
10771:
10765:
10761:
10757:
10752:
10742:
10738:
10734:
10729:
10723:
10719:
10715:
10710:
10704:
10697:
10693:
10689:
10685:
10682:
10680:
10677:
10676:
10674:
10669:
10659:
10653:
10650:
10648:
10645:
10643:
10640:
10638:
10635:
10633:
10630:
10628:
10625:
10623:
10620:
10618:
10615:
10613:
10610:
10608:
10605:
10603:
10600:
10598:
10595:
10593:
10590:
10588:
10585:
10583:
10580:
10578:
10575:
10573:
10570:
10568:
10561:
10559:
10556:
10554:
10551:
10549:
10546:
10544:
10541:
10539:
10536:
10534:
10531:
10529:
10526:
10524:
10521:
10519:
10516:
10514:
10511:
10509:
10506:
10504:
10501:
10499:
10496:
10492:
10489:
10487:
10484:
10482:
10479:
10477:
10474:
10472:
10469:
10467:
10464:
10462:
10459:
10457:
10454:
10452:
10449:
10447:
10444:
10442:
10439:
10437:
10434:
10432:
10429:
10427:
10424:
10420:
10417:
10415:
10412:
10410:
10407:
10405:
10402:
10400:
10397:
10395:
10392:
10390:
10387:
10383:
10380:
10378:
10375:
10371:
10368:
10366:
10363:
10361:
10358:
10354:
10351:
10349:
10348:Fluproquazone
10346:
10345:Quinazolines:
10342:
10339:
10337:
10334:
10332:
10329:
10325:
10322:
10320:
10317:
10315:
10312:
10310:
10307:
10305:
10302:
10300:
10297:
10295:
10292:
10290:
10287:
10283:
10280:
10278:
10275:
10273:
10270:
10268:
10265:
10263:
10260:
10256:
10253:
10251:
10248:
10246:
10243:
10241:
10238:
10236:
10233:
10231:
10228:
10226:
10223:
10221:
10218:
10216:
10213:
10209:
10206:
10204:
10201:
10199:
10196:
10194:
10191:
10189:
10186:
10184:
10181:
10179:
10176:
10174:
10171:
10169:
10166:
10164:
10161:
10159:
10156:
10154:
10151:
10149:
10146:
10144:
10141:
10139:
10136:
10134:
10131:
10129:
10126:
10124:
10123:Flunoxaprofen
10121:
10119:
10116:
10114:
10111:
10109:
10108:Dexketoprofen
10106:
10104:
10103:Dexindoprofen
10101:
10099:
10096:
10094:
10091:
10089:
10086:
10084:
10081:
10079:
10076:
10074:
10071:
10067:
10064:
10062:
10059:
10057:
10054:
10052:
10049:
10047:
10044:
10042:
10041:Proglumetacin
10039:
10037:
10034:
10032:
10029:
10027:
10024:
10022:
10019:
10017:
10014:
10012:
10009:
10007:
10004:
10002:
9999:
9997:
9994:
9992:
9989:
9987:
9984:
9982:
9979:
9977:
9974:
9972:
9971:Difenpiramide
9969:
9967:
9964:
9962:
9959:
9957:
9954:
9952:
9949:
9947:
9944:
9942:
9939:
9937:
9934:
9932:
9929:
9927:
9924:
9922:
9919:
9917:
9914:
9912:
9909:
9908:Acetic acids:
9905:
9902:
9900:
9897:
9895:
9892:
9890:
9887:
9885:
9882:
9880:
9877:
9875:
9872:
9870:
9867:
9865:
9862:
9860:
9857:
9855:
9852:
9850:
9847:
9845:
9842:
9840:
9837:
9835:
9832:
9830:
9827:
9825:
9822:
9820:
9817:
9814:
9813:
9811:
9809:
9797:
9794:
9790:
9784:
9780:
9770:
9767:
9765:
9762:
9760:
9757:
9755:
9752:
9750:
9747:
9745:
9742:
9740:
9737:
9735:
9732:
9730:
9727:
9725:
9722:
9720:
9717:
9715:
9712:
9710:
9707:
9705:
9702:
9700:
9697:
9695:
9692:
9690:
9687:
9685:
9682:
9680:
9677:
9675:
9672:
9670:
9667:
9665:
9662:
9660:
9657:
9655:
9652:
9650:
9647:
9645:
9642:
9640:
9639:Fenprostalene
9637:
9635:
9632:
9630:
9627:
9625:
9622:
9620:
9617:
9615:
9612:
9610:
9607:
9605:
9602:
9600:
9597:
9595:
9592:
9590:
9589:Delprostenate
9587:
9585:
9582:
9580:
9577:
9575:
9572:
9570:
9567:
9565:
9562:
9561:
9559:
9555:
9549:
9546:
9544:
9541:
9539:
9536:
9534:
9531:
9529:
9526:
9524:
9521:
9519:
9516:
9514:
9511:
9509:
9506:
9504:
9501:
9499:
9496:
9494:
9488:
9486:
9483:
9481:
9478:
9476:
9473:
9471:
9468:
9466:
9463:
9461:
9458:
9456:
9453:
9451:
9448:
9446:
9443:
9441:
9438:
9436:
9433:
9431:
9428:
9426:
9423:
9421:
9418:
9416:
9413:
9411:
9408:
9406:
9403:
9401:
9398:
9396:
9393:
9391:
9388:
9386:
9383:
9380:
9379:
9376:
9373:
9371:
9368:
9366:
9362:Thromboxane A
9360:
9358:
9355:
9353:
9347:
9344:
9343:
9341:
9336:
9326:
9320:
9317:
9314:
9313:
9310:
9307:
9305:
9302:
9300:
9297:
9295:
9292:
9290:
9287:
9285:
9284:(alprostadil)
9278:
9276:
9269:
9267:
9264:
9262:
9259:
9257:
9254:
9252:
9249:
9247:
9244:
9242:
9239:
9237:
9234:
9232:
9229:
9227:
9224:
9222:
9219:
9216:
9215:
9213:
9208:
9198:
9192:
9189:
9187:
9184:
9182:
9179:
9177:
9174:
9172:
9165:
9163:
9157:
9155:
9152:
9150:
9147:
9145:
9142:
9140:
9137:
9135:
9132:
9130:
9127:
9125:
9122:
9119:
9118:
9116:
9111:
9101:
9091:
9088:
9086:
9083:
9081:
9074:
9072:
9069:
9067:
9064:
9062:
9059:
9057:
9054:
9052:
9049:
9047:
9044:
9042:
9036:
9033:
9032:
9030:
9026:
9020:
9017:
9015:
9012:
9010:
9007:
9005:
9002:
8999:
8998:
8995:
8992:
8990:
8983:
8981:
8980:(alprostadil)
8974:
8972:
8969:
8967:
8964:
8961:
8960:
8958:
8953:
8944:
8938:
8935:
8932:
8931:
8928:
8925:
8923:
8920:
8918:
8915:
8913:
8906:
8904:
8903:(alprostadil)
8897:
8895:
8889:
8887:
8884:
8882:
8879:
8877:
8874:
8872:
8869:
8867:
8864:
8862:
8859:
8857:
8854:
8852:
8849:
8846:
8845:
8843:
8838:
8829:
8823:
8820:
8818:
8815:
8813:
8810:
8807:
8806:
8803:
8800:
8798:
8791:
8789:
8788:(alprostadil)
8782:
8780:
8777:
8775:
8772:
8769:
8768:
8766:
8761:
8752:
8746:
8743:
8741:
8738:
8736:
8733:
8731:
8728:
8726:
8723:
8720:
8719:
8716:
8713:
8711:
8704:
8702:
8701:(alprostadil)
8695:
8693:
8690:
8688:
8685:
8683:
8680:
8678:
8675:
8673:
8670:
8668:
8665:
8662:
8661:
8659:
8654:
8645:
8642:
8637:
8627:
8617:
8614:
8612:
8609:
8607:
8604:
8602:
8599:
8597:
8594:
8592:
8589:
8587:
8584:
8582:
8579:
8577:
8574:
8572:
8569:
8567:
8564:
8562:
8559:
8556:
8555:
8552:
8546:
8544:
8541:
8538:
8537:
8535:
8530:
8521:
8515:
8512:
8510:
8507:
8505:
8502:
8499:
8498:
8495:
8492:
8490:
8484:
8481:
8480:
8478:
8473:
8464:
8461:
8456:
8446:
8443:
8439:
8433:
8429:
8425:
8422:
8419:
8412:
8407:
8405:
8400:
8398:
8393:
8392:
8389:
8373:
8371:
8368:
8367:
8365:
8362:
8359:
8356:
8354:
8351:
8350:
8346:
8340:
8337:
8335:
8332:
8330:
8327:
8325:
8322:
8320:
8317:
8315:
8312:
8310:
8307:
8305:
8302:
8300:
8297:
8295:
8292:
8290:
8287:
8285:
8282:
8280:
8277:
8275:
8272:
8271:
8269:
8265:
8259:
8256:
8254:
8253:Methocarbamol
8251:
8249:
8248:Mephenoxalone
8246:
8244:
8241:
8239:
8238:Chlorzoxazone
8236:
8234:
8231:
8230:
8228:
8226:
8222:
8212:
8209:
8208:
8206:
8204:
8200:
8194:
8191:
8189:
8186:
8184:
8181:
8174:
8173:
8169:
8168:amitriptyline
8165:
8162:
8160:
8157:
8155:
8152:
8149:
8145:
8141:
8138:
8136:
8133:
8131:
8130:Carbamazepine
8128:
8127:
8125:
8123:
8119:
8113:
8110:
8108:
8105:
8103:
8100:
8098:
8095:
8093:
8090:
8088:
8085:
8083:
8080:
8079:
8077:
8075:
8071:
8068:
8066:
8060:
8054:
8051:
8049:
8046:
8044:
8041:
8039:
8036:
8034:
8031:
8030:
8028:
8026:
8022:
8012:
8009:
8007:
8004:
8002:
7999:
7997:
7994:
7992:
7989:
7987:
7984:
7983:
7981:
7977:
7970:
7963:
7960:
7958:
7955:
7953:
7950:
7948:
7945:
7943:
7940:
7938:
7935:
7934:
7932:
7930:
7926:
7919:
7912:
7909:
7907:
7904:
7902:
7899:
7897:
7894:
7892:
7889:
7887:
7884:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7847:
7844:
7842:
7839:
7837:
7834:
7832:
7829:
7826:
7822:
7819:
7818:
7816:
7814:
7810:
7804:
7801:
7799:
7796:
7794:
7791:
7789:
7786:
7785:
7783:
7781:
7777:
7771:
7768:
7766:
7763:
7761:
7758:
7756:
7753:
7751:
7748:
7745:
7738:
7735:
7734:
7732:
7730:
7726:
7720:
7717:
7715:
7712:
7710:
7707:
7705:
7702:
7699:
7692:
7689:
7687:
7684:
7682:
7679:
7677:
7674:
7672:
7669:
7668:
7666:
7662:
7656:
7653:
7651:
7648:
7646:
7643:
7641:
7638:
7636:
7633:
7632:
7630:
7626:
7620:
7617:
7615:
7612:
7610:
7607:
7605:
7602:
7600:
7597:
7595:
7592:
7589:
7588:Dexketoprofen
7582:
7579:
7576:
7568:
7561:
7558:
7556:
7553:
7551:
7548:
7546:
7543:
7542:
7540:
7536:
7533:
7531:
7527:
7521:
7518:
7516:
7513:
7511:
7508:
7504:
7501:
7499:
7496:
7494:
7491:
7489:
7486:
7484:
7481:
7479:
7476:
7474:
7471:
7469:
7466:
7465:
7464:
7461:
7459:
7456:
7454:
7451:
7449:
7446:
7445:
7443:
7440:
7436:
7426:
7423:
7420:
7416:
7409:
7406:
7404:
7401:
7399:
7396:
7394:
7391:
7389:
7386:
7384:
7381:
7379:
7376:
7374:
7371:
7369:
7366:
7364:
7363:Phenoperidine
7361:
7359:
7356:
7354:
7351:
7349:
7346:
7344:
7341:
7339:
7336:
7334:
7331:
7329:
7326:
7324:
7321:
7319:
7316:
7314:
7311:
7309:
7306:
7303:
7299:
7296:
7294:
7293:Ethoheptazine
7291:
7289:
7286:
7284:
7281:
7279:
7276:
7274:
7271:
7269:
7266:
7264:
7261:
7259:
7256:
7254:
7251:
7249:
7246:
7244:
7241:
7240:
7238:
7234:
7228:
7225:
7223:
7220:
7218:
7215:
7212:
7208:
7204:
7200:
7196:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7166:
7164:
7161:
7159:
7156:
7154:
7153:Hydromorphone
7151:
7149:
7146:
7143:
7139:
7135:
7128:
7125:
7123:
7122:Ethylmorphine
7120:
7118:
7115:
7113:
7110:
7107:
7100:
7097:
7095:
7092:
7090:
7087:
7085:
7082:
7079:
7072:
7071:Buprenorphine
7069:
7067:
7064:
7062:
7059:
7058:
7056:
7054:Semisynthetic
7052:
7046:
7043:
7041:
7038:
7036:
7033:
7030:
7026:
7023:
7019:
7016:
7014:
7011:
7010:
7009:
7006:
7005:
7003:
7001:
6997:
6993:
6990:
6988:
6984:
6979:
6975:
6971:
6964:
6959:
6957:
6952:
6950:
6945:
6944:
6941:
6929:
6926:
6924:
6921:
6919:
6916:
6915:
6913:
6909:
6903:
6900:
6899:
6897:
6894:
6890:
6880:
6877:
6875:
6872:
6870:
6867:
6865:
6864:Niflumic acid
6862:
6860:
6857:
6855:
6852:
6850:
6847:
6845:
6842:
6840:
6837:
6835:
6832:
6830:
6827:
6825:
6822:
6820:
6817:
6815:
6812:
6810:
6807:
6805:
6802:
6800:
6797:
6796:
6794:
6790:
6784:
6781:
6779:
6776:
6774:
6771:
6770:
6768:
6764:
6760:
6754:
6751:
6749:
6746:
6744:
6741:
6739:
6736:
6735:
6733:
6731:
6730:Pyrazolidines
6727:
6724:
6722:
6719:preparations,
6714:
6709:
6705:
6704:muscular pain
6701:
6698:products for
6697:
6690:
6685:
6683:
6678:
6676:
6671:
6670:
6667:
6655:
6651:
6647:
6645:
6637:
6635:
6627:
6626:
6623:
6618:
6614:
6610:
6606:
6600:
6594:
6591:
6589:
6586:
6584:
6581:
6579:
6576:
6574:
6571:
6569:
6566:
6564:
6561:
6560:
6558:
6552:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6500:Fluproquazone
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6478:
6477:
6475:
6471:
6465:
6462:
6460:
6457:
6455:
6452:
6450:
6447:
6445:
6442:
6440:
6437:
6435:
6432:
6430:
6427:
6425:
6422:
6420:
6417:
6414:
6410:
6409:
6405:
6403:
6400:
6399:
6397:
6393:
6389:
6383:
6380:
6378:
6377:Niflumic acid
6375:
6373:
6370:
6368:
6367:
6363:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6317:
6315:
6312:
6306:
6302:
6296:
6292:
6291:
6287:
6285:
6282:
6280:
6277:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6234:
6230:
6228:
6225:
6223:
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6202:
6198:
6196:
6193:
6191:
6190:Flunoxaprofen
6188:
6186:
6183:
6181:
6178:
6176:
6175:Dexketoprofen
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6156:
6153:
6152:
6150:
6147:
6144:derivatives (
6142:
6138:
6132:
6129:
6127:
6124:
6122:
6121:
6117:
6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6091:
6089:
6087:
6083:
6077:
6074:
6072:
6069:
6067:
6064:
6062:
6059:
6057:
6056:Proglumetacin
6054:
6052:
6051:Prodolic acid
6049:
6047:
6044:
6042:
6039:
6037:
6034:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6012:
6009:
6007:
6004:
6002:
5999:
5997:
5994:
5992:
5991:Difenpiramide
5989:
5987:
5986:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5952:
5950:
5947:
5945:
5942:
5941:
5939:
5934:
5930:
5924:
5921:
5919:
5916:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5853:
5849:
5848:
5846:
5844:
5840:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5818:
5814:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5743:
5741:
5739:
5738:pyrazolidines
5734:
5730:
5725:
5721:
5717:
5713:
5706:
5701:
5699:
5694:
5692:
5687:
5686:
5683:
5671:
5668:
5666:
5663:
5661:
5658:
5655:
5651:
5648:
5646:
5643:
5641:
5638:
5636:
5635:Oxymetazoline
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5575:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5510:
5506:
5503:
5501:
5498:
5496:
5493:
5492:
5490:
5486:
5480:
5477:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5454:
5453:
5452:
5451:Antiandrogens
5448:
5444:
5441:
5439:
5436:
5435:
5434:
5433:
5429:
5428:
5426:
5424:
5420:
5412:
5409:
5407:
5404:
5403:
5402:
5399:
5395:
5392:
5391:
5390:
5389:
5385:
5381:
5378:
5376:
5373:
5371:
5368:
5366:
5363:
5361:
5358:
5357:
5356:
5355:
5354:Antiandrogens
5351:
5347:
5344:
5342:
5339:
5337:
5334:
5332:
5329:
5328:
5327:
5326:
5322:
5321:
5319:
5317:
5313:
5306:
5302:
5301:
5297:
5296:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5269:
5267:
5265:
5261:
5255:
5252:
5250:
5249:Afamelanotide
5247:
5246:
5244:
5242:
5238:
5232:
5229:
5227:
5224:
5222:
5219:
5218:
5216:
5214:
5210:
5203:
5199:
5198:
5194:
5190:
5187:
5185:
5182:
5181:
5180:
5179:
5178:Lithium salts
5175:
5170:
5166:
5163:
5161:
5158:
5156:
5153:
5151:
5148:
5146:
5143:
5142:
5141:
5140:
5136:
5134:
5131:
5127:
5124:
5122:
5119:
5117:
5114:
5113:
5112:
5111:
5107:
5105:
5104:
5100:
5096:
5093:
5091:
5088:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5050:
5046:
5043:
5041:
5038:
5037:
5036:
5035:
5031:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5008:
5007:
5006:
5005:Antiandrogens
5002:
5001:
4999:
4997:
4993:
4988:
4984:
4976:
4971:
4969:
4964:
4962:
4957:
4956:
4953:
4947:
4943:
4938:
4934:
4933:
4928:
4923:
4922:
4909:
4905:
4901:
4897:
4892:
4887:
4883:
4879:
4875:
4868:
4852:
4848:
4844:
4838:
4822:
4818:
4814:
4807:
4791:
4787:
4783:
4777:
4761:
4757:
4753:
4747:
4731:
4727:
4723:
4717:
4701:
4697:
4693:
4686:
4670:
4666:
4665:New Scientist
4662:
4655:
4639:
4635:
4631:
4627:
4623:
4619:
4615:
4611:
4607:
4603:
4599:
4595:
4588:
4580:
4576:
4572:
4568:
4564:
4560:
4556:
4552:
4544:
4537:(5): 217–226.
4536:
4533:(in German).
4532:
4524:
4517:
4509:
4505:
4501:
4497:
4493:
4489:
4485:
4481:
4473:
4465:
4461:
4457:
4453:
4449:
4445:
4441:
4437:
4429:
4413:
4409:
4405:
4398:
4390:
4386:
4381:
4376:
4371:
4366:
4362:
4358:
4354:
4347:
4345:
4343:
4326:
4322:
4316:
4314:
4297:
4293:
4289:
4283:
4275:
4271:
4266:
4261:
4257:
4253:
4249:
4245:
4238:
4230:
4226:
4221:
4216:
4212:
4208:
4204:
4200:
4196:
4189:
4181:
4177:
4173:
4169:
4165:
4161:
4157:
4153:
4149:
4145:
4138:
4122:
4118:
4114:
4108:
4092:
4088:
4084:
4077:
4071:
4067:
4057:
4051:
4043:
4037:
4033:
4026:
4018:
4014:
4009:
4004:
4000:
3996:
3992:
3985:
3977:
3973:
3968:
3963:
3959:
3955:
3951:
3947:
3943:
3936:
3934:
3925:
3921:
3917:
3913:
3909:
3905:
3901:
3897:
3889:
3881:
3877:
3873:
3869:
3865:
3861:
3854:
3846:
3842:
3837:
3832:
3828:
3824:
3820:
3816:
3812:
3805:
3797:
3793:
3789:
3785:
3781:
3777:
3770:
3768:
3759:
3755:
3751:
3747:
3743:
3739:
3732:
3724:
3720:
3716:
3712:
3708:
3704:
3697:
3689:
3685:
3681:
3677:
3674:(4B): 34–38.
3673:
3669:
3662:
3654:
3650:
3646:
3642:
3639:(4B): 18–23.
3638:
3634:
3627:
3619:
3615:
3611:
3607:
3603:
3599:
3592:
3576:
3572:
3568:
3564:
3560:
3556:
3549:
3533:
3529:
3525:
3521:
3517:
3513:
3506:
3504:
3495:
3491:
3487:
3483:
3479:
3475:
3468:
3453:
3449:
3445:
3441:
3434:
3426:
3422:
3417:
3412:
3407:
3402:
3398:
3394:
3390:
3386:
3382:
3375:
3359:
3355:
3351:
3345:
3337:
3333:
3329:
3325:
3321:
3314:
3312:
3310:
3301:
3297:
3292:
3287:
3283:
3279:
3275:
3268:
3266:
3257:
3253:
3252:
3247:
3241:
3233:
3229:
3225:
3221:
3217:
3213:
3206:
3198:
3194:
3189:
3184:
3180:
3176:
3172:
3165:
3157:
3153:
3149:
3145:
3141:
3137:
3133:
3129:
3121:
3105:
3101:
3097:
3091:
3075:
3071:
3067:
3061:
3053:
3049:
3044:
3039:
3035:
3031:
3027:
3023:
3019:
3012:
3005:
3004:public domain
2986:
2982:
2978:
2972:
2970:
2962:
2961:public domain
2943:
2939:
2937:
2931:
2925:
2923:
2914:
2910:
2905:
2900:
2896:
2892:
2888:
2884:
2880:
2873:
2871:
2869:
2867:
2865:
2863:
2861:
2859:
2842:
2838:
2834:
2828:
2820:
2816:
2811:
2806:
2802:
2798:
2797:Pain Medicine
2794:
2787:
2771:
2767:
2765:
2760:
2754:
2746:
2742:
2737:
2732:
2728:
2724:
2720:
2716:
2712:
2705:
2694:
2690:
2683:
2677:
2669:
2665:
2661:
2657:
2651:
2643:
2639:
2635:
2631:
2627:
2623:
2616:
2608:
2604:
2600:
2594:
2586:
2582:
2576:
2574:
2566:
2554:
2550:
2546:
2539:
2537:
2535:
2516:
2509:
2508:
2499:
2497:
2495:
2486:
2482:
2478:
2474:
2470:
2466:
2462:
2458:
2450:
2448:
2446:
2444:
2435:
2431:
2426:
2421:
2417:
2413:
2409:
2405:
2401:
2394:
2392:
2390:
2374:
2370:
2364:
2348:
2344:
2340:
2334:
2326:
2320:
2316:
2315:
2308:
2300:
2294:
2290:
2284:
2282:
2280:
2278:
2269:
2265:
2261:
2257:
2253:
2249:
2242:
2234:
2228:
2224:
2223:
2215:
2199:
2195:
2188:
2172:
2168:
2162:
2158:
2154:
2150:
2146:
2139:
2124:
2123:
2118:
2112:
2110:
2108:
2106:
2104:
2102:
2100:
2098:
2096:
2094:
2078:
2074:
2068:
2061:
2060:public domain
2042:
2041:
2036:
2030:
2028:
2012:. 6 June 2024
2011:
2010:
2009:Health Canada
2005:
1999:
1984:
1980:
1976:
1970:
1954:
1950:
1944:
1928:
1924:
1920:
1914:
1912:
1910:
1905:
1897:
1895:
1891:
1887:
1886:visceral gout
1883:
1878:
1868:
1864:
1862:
1856:
1854:
1850:
1846:
1843:
1838:
1836:
1832:
1828:
1827:
1822:
1817:
1815:
1814:
1809:
1805:
1800:
1799:Steppe eagles
1796:
1794:
1789:
1785:
1781:
1776:
1772:
1761:
1758:December 2022
1751:
1745:
1741:
1737:
1734:This section
1732:
1728:
1723:
1722:
1714:
1711:
1709:
1703:
1699:
1686:
1684:
1680:
1676:
1672:
1668:
1664:
1654:
1652:
1648:
1640:
1636:
1633:
1629:
1626:
1622:
1621:
1620:
1618:
1613:
1611:
1607:
1603:
1599:
1594:
1592:
1588:
1584:
1580:
1575:
1573:
1569:
1564:
1561:
1559:
1554:
1552:
1548:
1544:
1540:
1536:
1532:
1528:
1514:
1513:
1510:Mental health
1503:
1500:
1496:
1495:
1485:
1481:
1477:
1473:
1469:
1465:
1461:
1460:
1451:
1447:
1443:
1438:
1437:
1431:
1429:
1424:
1422:
1417:
1412:
1410:
1406:
1401:
1398:
1393:
1384:
1381:
1377:
1372:
1369:
1365:
1361:
1355:
1342:
1338:
1334:
1330:
1327:
1324:
1321:
1317:
1314:
1311:
1307:
1304:
1300:
1297:
1294:
1291:
1287:
1283:
1281:
1277:
1273:
1270:
1268:
1264:
1260:
1258:
1255:
1253:
1249:
1245:
1241:
1237:
1233:
1230:
1229:
1219:
1212:
1207:
1203:
1196:
1191:
1187:
1183:
1176:
1171:
1167:
1163:
1157:
1152:
1148:
1141:
1136:
1135:
1134:
1132:
1127:
1125:
1119:
1117:
1113:
1109:
1104:
1102:
1098:
1094:
1093:kidney stones
1090:
1086:
1082:
1078:
1074:
1071:
1061:
1059:
1054:
1047:
1045:
1041:
1040:breastfeeding
1037:
1033:
1029:
1025:
1021:
1020:heart disease
1017:
1013:
1008:
1006:
1002:
998:
994:
993:intravenously
990:
986:
982:
978:
974:
970:
966:
962:
958:
952:
908:
866:
856:
849:
843:
834:
829:
828:
825:
818:
809:
808:
805:
798:
791:
787:
786:
784:
781:
776:
769:
767:
763:
733:
731:
727:
722:
718:
714:
711:
709:
707:ECHA InfoCard
703:
695:
691:
690:DTXSID6022923
687:
686:
684:
675:
671:
663:
662:RCSB PDB
657:
652:
651:
649:
647:
643:
636:
632:
631:
629:
627:
623:
616:
612:
611:
609:
607:
603:
596:
592:
591:
589:
587:
583:
576:
572:
571:
569:
567:
563:
556:
552:
551:
549:
547:
543:
536:
532:
531:
529:
527:
523:
516:
512:
511:
509:
507:
503:
496:
492:
491:
489:
482:
478:
471:
467:
466:
464:
462:
458:
449:
448:
445:
438:
433:
430:
426:
422:
420:
416:
412:
408:
406:
399:
395:
393:
389:
385:
381:
377:
373:
369:
365:
361:
359:
355:
352:More than 99%
351:
349:
345:
341:
337:
330:
327:
315:
312:
302:
300:
291:
288:
278:
277:
275:
273:
269:
264:
256:
251:
246:
241:
236:
231:
226:
221:
218:
217:
215:
213:
209:
206:
202:
198:
197:intramuscular
194:
190:
187:
185:
179:
173:
164:
163:
161:
159:
153:
146:
141:
132:
131:
129:
127:
123:
119:
115:
113:
109:
105:
101:
99:
95:
91:
88:
84:
82:
78:
75:Clinical data
73:
66:
61:
57:
52:
44:
40:
33:
19:
11013:Nephrotoxins
11008:Hepatotoxins
10993:Chloroarenes
10983:Acetic acids
10937:
10930:
10875:
10494:
10422:
10419:Propacetamol
10409:Parapropamol
10385:
10373:
10356:
10344:
10336:Floctafenine
10327:
10285:
10262:Azapropazone
10259:Pyrazolones:
10258:
10211:
10193:Tarenflurbil
10128:Flurbiprofen
10098:Dexibuprofen
10078:Benoxaprofen
10073:Alminoprofen
10069:
9996:Glucametacin
9965:
9907:
9884:Salicylamide
9874:Salacetamide
9815:
9764:Trimoprostil
9759:Tiprostanide
9744:Spiriprostil
9679:Naxaprostene
9629:Esuberaprost
9584:Cobiprostone
9382:Antagonists:
9381:
9345:
9316:Antagonists:
9315:
9309:Treprostinil
9217:
9149:Fluprostenol
9139:Cloprostenol
9120:
9034:
9001:Antagonists:
9000:
8966:Lubiprostone
8962:
8934:Antagonists:
8933:
8847:
8809:Antagonists:
8808:
8802:Treprostinil
8770:
8722:Antagonists:
8721:
8687:Lubiprostone
8663:
8558:Antagonists:
8557:
8539:
8501:Antagonists:
8500:
8494:Treprostinil
8482:
8258:Orphenadrine
8233:Carisoprodol
8225:Myorelaxants
8175:
8025:Cannabinoids
7991:Floctafenine
7896:Salicylamide
7680:
7575:+paracetamol
7567:Dexibuprofen
7555:Flurbiprofen
7545:Benoxaprofen
7520:Propacetamol
7510:Parapropamol
7478:+hydrocodone
7419:+paracetamol
7388:Remifentanil
7378:Proheptazine
7308:Ketobemidone
7248:Alphaprodine
7195:+paracetamol
7183:Nicomorphine
7178:Nicodicodine
7134:+paracetamol
7106:+paracetamol
7089:Desomorphine
7018:+paracetamol
6923:Idrocilamide
6869:Piketoprofen
6829:Flurbiprofen
6772:
6743:Mofebutazone
6721:non-steroids
6604:
6556:combinations
6406:
6372:Morniflumate
6364:
6335:Floctafenine
6320:Azapropazone
6304:
6288:
6264:Tarenflurbil
6249:Piketoprofen
6244:Pelubiprofen
6231:
6199:
6195:Flurbiprofen
6170:Dexibuprofen
6160:Benoxaprofen
6155:Alminoprofen
6118:
5984:
5983:
5913:Salicylamide
5850:
5815:
5791:Mofebutazone
5771:Famprofazone
5766:Difenamizole
5756:Azapropazone
5670:Tralokinumab
5654:progesterone
5650:Progestogens
5620:Metandienone
5605:Lebrikizumab
5559:
5550:Delgocitinib
5509:testosterone
5479:Eflornithine
5457:Bicalutamide
5449:
5430:
5411:Ritlecitinib
5400:
5386:
5360:Bicalutamide
5352:
5323:
5298:
5287:Pimecrolimus
5272:Alitretinoin
5254:Melanotan II
5221:Hydroquinone
5195:
5176:
5139:Keratolytics
5137:
5133:Isotretinoin
5121:Pimecrolimus
5108:
5101:
5070:Ketoconazole
5065:Clotrimazole
5032:
5011:Bicalutamide
5003:
4930:
4881:
4877:
4867:
4855:. Retrieved
4846:
4837:
4825:. Retrieved
4816:
4806:
4794:. Retrieved
4790:the original
4785:
4776:
4764:. Retrieved
4760:the original
4755:
4746:
4734:. Retrieved
4725:
4716:
4704:. Retrieved
4695:
4685:
4673:. Retrieved
4664:
4654:
4642:. Retrieved
4601:
4597:
4587:
4554:
4550:
4543:
4534:
4530:
4516:
4483:
4479:
4472:
4439:
4435:
4428:
4416:. Retrieved
4407:
4397:
4360:
4357:PLOS Biology
4356:
4329:. Retrieved
4300:. Retrieved
4291:
4282:
4247:
4243:
4237:
4202:
4198:
4188:
4147:
4143:
4137:
4125:. Retrieved
4116:
4107:
4095:. Retrieved
4086:
4076:
4050:
4031:
4025:
3998:
3994:
3984:
3949:
3945:
3899:
3895:
3888:
3863:
3859:
3853:
3818:
3814:
3804:
3779:
3775:
3741:
3737:
3731:
3706:
3702:
3696:
3671:
3667:
3661:
3636:
3632:
3626:
3601:
3597:
3591:
3579:. Retrieved
3562:
3558:
3548:
3536:. Retrieved
3519:
3515:
3477:
3473:
3467:
3455:. Retrieved
3443:
3440:"Diclofenac"
3433:
3388:
3384:
3374:
3362:. Retrieved
3353:
3344:
3319:
3281:
3277:
3256:the original
3249:
3240:
3215:
3211:
3205:
3178:
3174:
3164:
3131:
3127:
3120:
3108:. Retrieved
3099:
3090:
3078:. Retrieved
3069:
3060:
3025:
3021:
3011:
2989:. Retrieved
2980:
2946:. Retrieved
2933:
2886:
2882:
2845:. Retrieved
2836:
2827:
2800:
2796:
2786:
2774:. Retrieved
2770:the original
2762:
2753:
2718:
2714:
2704:
2693:the original
2688:
2676:
2659:
2650:
2625:
2621:
2615:
2603:cambiarx.com
2602:
2593:
2585:the original
2564:
2557:. Retrieved
2549:The Guardian
2548:
2522:, retrieved
2505:
2460:
2456:
2407:
2403:
2376:. Retrieved
2372:
2363:
2351:. Retrieved
2342:
2333:
2313:
2307:
2288:
2254:(2): 65–71.
2251:
2247:
2241:
2220:
2214:
2202:. Retrieved
2198:the original
2187:
2175:. Retrieved
2148:
2138:
2126:. Retrieved
2120:
2080:. Retrieved
2077:YouDrugstore
2076:
2067:
2045:. Retrieved
2038:
2014:. Retrieved
2007:
1998:
1986:. Retrieved
1978:
1969:
1957:. Retrieved
1952:
1943:
1931:. Retrieved
1922:
1919:"Diclofenac"
1874:
1865:
1857:
1839:
1824:
1818:
1811:
1797:
1777:
1774:
1755:
1735:
1712:
1704:
1700:
1697:
1683:generic drug
1670:
1666:
1662:
1660:
1644:
1632:ion channels
1615:Besides the
1614:
1610:heart attack
1595:
1583:leukotrienes
1579:lipoxygenase
1576:
1565:
1562:
1555:
1524:
1521:Pharmacology
1425:
1413:
1394:
1390:
1373:
1357:
1320:dengue fever
1236:bronchospasm
1128:
1120:
1105:
1081:dysmenorrhea
1067:
1064:Medical uses
1055:
1048:
1009:
956:
867:(pronounced
864:
863:
852:
846:
402:Elimination
272:Legal status
266:Legal status
126:License data
43:
10998:Dermatoxins
10876:Precursors:
10816:Nicogrelate
10796:Furegrelate
10737:Bimatoprost
10647:Trifenagrel
10637:Tiflamizole
10607:Rutecarpine
10592:Resveratrol
10533:Glimepiride
10498:Anitrazafen
10476:Robenacoxib
10456:Lumiracoxib
10389:Acetanilide
10331:Antrafenine
10289:Ampiroxicam
10183:Pranoprofen
10168:Naproxcinod
10061:Zidometacin
9986:Fenclofenac
9911:Aceclofenac
9849:Ethenzamide
9844:Dipyrocetyl
9739:Rosaprostol
9719:Posaraprost
9704:Penprostene
9694:Ornoprostil
9674:Mexiprostil
9669:Meteneprost
9624:Eptaloprost
9599:Dimoxaprost
9564:Arbaprostil
9518:Seratrodast
9410:BMS-180,291
9241:Carbacyclin
9191:Unoprostone
9171:(dinoprost)
9154:Latanoprost
9129:Bimatoprost
9124:Alfaprostol
9080:(dinoprost)
9019:ONO-AE3-208
8971:Misoprostol
8927:Sulprostone
8917:Remiprostol
8886:Misoprostol
8881:Latanoprost
8856:Carbacyclin
8817:PF-04418948
8779:Misoprostol
8715:Sulprostone
8692:Misoprostol
8682:Latanoprost
8616:Vidupiprant
8606:Timapiprant
8601:Setipiprant
8576:Fevipiprant
8543:Indometacin
8514:Vidupiprant
8509:Laropiprant
8360:from market
8304:Frunevetmab
8284:Bedinvetmab
8193:PF-05089771
8102:Mirogabalin
8063:Ion channel
8033:Cannabidiol
7986:Benzydamine
7929:Pyrazolones
7911:Wintergreen
7861:Ethenzamide
7856:Dipyrocetyl
7813:Salicylates
7755:Lumiracoxib
7691:Indometacin
7619:Zaltoprofen
7538:Propionates
7448:Acetanilide
7439:Paracetamol
7373:Piritramide
7358:Phenazocine
7353:Phenadoxone
7343:Pentazocine
7338:Oliceridine
7333:Norpipanone
7302:+fluanisone
7283:Dimenoxadol
7263:Carfentanil
7258:Bezitramide
7253:Anileridine
7222:Papaveretum
7217:Oxymorphone
7211:+naltrexone
7173:Nicocodeine
7158:Levorphanol
7127:Hydrocodone
7084:Butorphanol
7029:+naltrexone
6902:Zucapsaicin
6895:derivatives
6839:Indometacin
6814:Etofenamate
6804:Benzydamine
6766:derivatives
6763:Acetic acid
6505:Glucosamine
6485:Benzydamine
6454:Robenacoxib
6439:Lumiracoxib
6330:Etofenamate
6295:Naproxcinod
6284:Zaltoprofen
6094:Ampiroxicam
6016:Indometacin
5944:Aceclofenac
5935:derivatives
5933:acetic acid
5883:Ethenzamide
5878:Dipyrocetyl
5843:salicylates
5733:pyrazolones
5660:Ruxolitinib
5630:Oclacitinib
5625:Nemolizumab
5540:Crisaborole
5520:Brimonidine
5495:Abrocitinib
5443:Finasteride
5438:Dutasteride
5341:Finasteride
5336:Dutasteride
5331:Alfatradiol
5231:Monobenzone
5116:Cyclosporin
5034:Antifungals
4925:‹ The
4847:Yle Uutiset
4766:18 February
4736:18 February
4706:12 December
4408:Pune Mirror
2847:15 November
2664:Mayo Clinic
2204:18 February
2128:18 February
2082:18 February
2047:18 February
1959:18 February
1933:22 December
1842:Zoroastrian
1604:with their
1535:antipyretic
1487:diclofenac.
1442:misoprostol
1339:(SJS), and
1218:topical gel
1202:suppository
1166:misoprostol
1075:related to
1005:misoprostol
1001:combination
987:, injected
985:suppository
773: g·mol
713:100.035.755
615:CHEBI:47381
451:acetic acid
435:Identifiers
201:intravenous
112:MedlinePlus
81:Trade names
10977:Categories
10846:Samixogrel
10841:Rolafagrel
10826:Picotamide
10806:Midazogrel
10781:Camonagrel
10642:Timegadine
10587:Pamicogrel
10558:Licofelone
10538:Hyperforin
10503:Clobuzarit
10491:Valdecoxib
10486:Tilmacoxib
10471:Polmacoxib
10446:Etoricoxib
10414:Phenacetin
10382:Nimesulide
10360:Clonixeril
10353:Proquazone
10309:Lornoxicam
10208:Vedaprofen
10158:Miroprofen
10153:Loxoprofen
10148:Ketoprofen
10143:Indoprofen
10118:Fenoprofen
10031:Oxametacin
10026:Nabumetone
9966:Diclofenac
9961:Clometacin
9956:Cinmetacin
9951:Bumadizone
9931:Alclofenac
9916:Acemetacin
9854:Guacetisal
9839:Diflunisal
9789:inhibitors
9754:Tilsuprost
9734:Rivenprost
9729:Rioprostil
9724:Prostalene
9709:Pimilprost
9699:Oxoprostol
9689:Nocloprost
9664:Luprostiol
9654:Lanproston
9649:Froxiprost
9644:Flunoprost
9634:Etiproston
9619:Enisoprost
9614:Eganoprost
9574:Ciprostene
9543:Terutroban
9533:Sulotroban
9513:Samixogrel
9498:Ramatroban
9485:Picotamide
9470:Mipitroban
9465:Linotroban
9450:Imitrodast
9440:ICI-192605
9435:ICI-185282
9420:Domitroban
9400:Argatroban
9299:Taprostene
9221:ACT-333679
9186:Travoprost
9181:Tafluprost
9176:Sulotroban
9134:Carboprost
9090:Taprenepag
9071:Omidenepag
9066:Nocloprost
9056:Evatanepag
9051:Carboprost
9004:Grapiprant
8596:Ramatroban
8504:Asapiprant
8424:modulators
8418:Prostanoid
8334:Rimazolium
8329:Proglumide
8274:Analgecine
8211:Flupirtine
8154:Mexiletine
8135:Lacosamide
8112:Ziconotide
8107:Pregabalin
8097:Leconotide
8087:Gabapentin
8065:modulators
8048:Nabiximols
8011:Proquazone
8006:Nimesulide
8001:Nabumetone
7952:Nifenazone
7866:Guacetisal
7851:Diflunisal
7836:Benorylate
7770:Valdecoxib
7750:Etoricoxib
7681:Diclofenac
7671:Acemetacin
7640:Lornoxicam
7594:Loxoprofen
7581:Ketoprofen
7550:Fenoprofen
7515:Phenacetin
7493:+oxycodone
7483:+ibuprofen
7415:+celecoxib
7398:Tapentadol
7393:Sufentanil
7368:Piminodine
7318:Meptazinol
7313:Lofentanil
7288:Dipipanone
7243:Alfentanil
7203:+ibuprofen
7168:Nalbuphine
7138:+ibuprofen
6970:Analgesics
6928:Tolazoline
6879:Suxibuzone
6859:Nifenazone
6844:Ketoprofen
6773:Diclofenac
6535:Proquazone
6525:Nimesulide
6520:Nabumetone
6515:Hyperforin
6464:Valdecoxib
6429:Etoricoxib
6279:Vedaprofen
6227:Miroprofen
6222:Loxoprofen
6217:Ketoprofen
6212:Indoprofen
6185:Fenoprofen
6109:Lornoxicam
6046:Oxametacin
5985:Diclofenac
5979:Bumadizone
5954:Alclofenac
5949:Acemetacin
5888:Guacetisal
5873:Diflunisal
5863:Benorylate
5833:Suxibuzone
5801:Nifenazone
5786:Metamizole
5665:Tiratricol
5610:Lokivetmab
5600:Ivermectin
5560:Diclofenac
5406:Nepidermin
5292:Tacrolimus
5150:Resorcinol
5126:Tacrolimus
5090:Xenysalate
5075:Miconazole
5060:Climbazole
5040:Bifonazole
4942:Diclofenac
4363:(3): e66.
4265:2263/13907
4117:www.gov.uk
4056:DE 1793592
4001:: 101159.
3457:15 January
3364:21 January
3110:14 January
2991:15 October
2948:15 October
2507:diclofenac
2463:: 148851.
2177:10 January
1988:22 October
1900:References
1821:feral dogs
1665:ranilino)
1516:reactions.
1450:omeprazole
1446:ranitidine
1421:odds ratio
1380:drug label
1352:See also:
1263:ulceration
1116:contusions
1097:gallstones
1087:and other
865:Diclofenac
778:3D model (
766:Molar mass
646:PDB ligand
575:144O8QL0L1
546:ChemSpider
506:IUPHAR/BPS
470:15307-86-5
461:CAS Number
444:IUPAC name
366:, also by
358:Metabolism
145:Diclofenac
48:Diclofenac
10851:Terbogrel
10831:Pirmagrel
10791:Dazoxiben
10786:Dazmegrel
10679:Retinoids
10597:Romazarit
10543:Itazigrel
10528:FR-122047
10523:Flumizole
10481:Rofecoxib
10466:Parecoxib
10461:Mavacoxib
10451:Firocoxib
10441:Deracoxib
10436:Cimicoxib
10431:Celecoxib
10426:Apricoxib
10377:Flosulide
10341:Glafenine
10324:Tenoxicam
10319:Piroxicam
10314:Meloxicam
10198:Tepoxalin
10178:Pirprofen
10173:Oxaprozin
10138:Ibuproxam
10133:Ibuprofen
10093:Carprofen
10088:Butibufen
10066:Zomepirac
10036:Oxindanac
10021:Mofezolac
10016:Lonazolac
10011:Ketorolac
9991:Fentiazac
9946:Bufexamac
9941:Bromfenac
9921:Aclofenac
9904:Triflusal
9894:Salsalate
9819:Aloxiprin
9769:Viprostol
9714:Piriprost
9684:Nileprost
9659:Limaprost
9609:Ecraprost
9604:Doxaprost
9594:Deprostil
9579:Clinprost
9538:Terbogrel
9528:SQ-29,548
9523:SQ-28,668
9480:ONO-11120
9445:Ifetroban
9415:Daltroban
9405:Bay U3405
9375:Vapiprost
9346:Agonists:
9319:RO1138452
9294:Selexipag
9289:Ralinepag
9246:Cicaprost
9236:BMY-45778
9231:Beraprost
9218:Agonists:
9144:Enprostil
9121:Agonists:
9085:Simenepag
9061:Gemeprost
9035:Agonists:
9009:GW-627368
8963:Agonists:
8866:Enprostil
8861:Cicaprost
8851:Beraprost
8848:Agonists:
8774:Butaprost
8771:Agonists:
8672:Enprostil
8667:Beraprost
8664:Agonists:
8571:Bay U3405
8540:Agonists:
8483:Agonists:
8421:signaling
8370:Phase III
8358:Withdrawn
8339:Tanezumab
8299:Clonidine
8294:Capsaicin
8148:lidocaine
7996:Glafenine
7957:Phenazone
7901:Salsalate
7831:Aloxiprin
7780:Fenamates
7765:Rofecoxib
7760:Parecoxib
7744:+tramadol
7737:Celecoxib
7719:Zomepirac
7704:Ketorolac
7676:Bromfenac
7655:Tenoxicam
7650:Piroxicam
7645:Meloxicam
7604:Oxaprozin
7560:Ibuprofen
7503:+tramadol
7458:Butacetin
7323:Methadone
7236:Synthetic
7207:+naloxone
7188:Oxycodone
7117:Etorphine
7078:+naloxone
7045:Paregoric
6893:Capsaicin
6874:Piroxicam
6834:Ibuprofen
6824:Feprazone
6809:Bufexamac
6778:Fentiazac
6738:Clofezone
6605:underline
6530:Oxaceprol
6495:Diacerein
6459:Rofecoxib
6449:Parecoxib
6444:Mavacoxib
6434:Firocoxib
6424:Deracoxib
6419:Cimicoxib
6413:+tramadol
6408:Celecoxib
6402:Apricoxib
6355:Glafenine
6350:Flutiazin
6311:fenamates
6269:Tepoxalin
6254:Pirprofen
6239:Oxaprozin
6207:Ibuproxam
6201:Ibuprofen
6165:Carprofen
6131:Tenoxicam
6126:Pivoxicam
6120:Piroxicam
6114:Meloxicam
6076:Zomepirac
6041:Mofezolac
6036:Lonazolac
6031:Ketorolac
6011:Fentiazac
5974:Bufexamac
5969:Bromfenac
5903:Salsalate
5858:Aloxiprin
5811:Phenazone
5776:Feprazone
5761:Clofezone
5574:estradiol
5570:Estrogens
5565:Dupilumab
5505:Androgens
5467:Flutamide
5394:Minoxidil
5370:Flutamide
5282:Oxaceprol
5049:cetrimide
5021:Flutamide
4634:207267290
4302:25 August
4017:2352-9148
3354:Drugs.com
2837:Drugs.com
2581:"Rufenal"
2378:30 August
2353:30 August
2122:Drugs.com
1953:Drugs.com
1923:Drugs.com
1882:uric acid
1816:species.
1793:Meloxicam
1788:livestock
1750:talk page
1587:autacoids
1539:analgesic
1527:mechanism
1464:Hepatitis
1428:celecoxib
1400:rofecoxib
1360:ibuprofen
1248:urticaria
1162:Arthrotec
1101:migraines
1077:arthritis
995:(IV), or
635:ChEMBL139
419:Excretion
404:half-life
384:sulfation
182:Routes of
156:Pregnancy
104:Monograph
98:Drugs.com
18:Dichronic
10988:Anilines
10967:Medicine
10927:See also
10836:Ridogrel
10811:Nafagrel
10801:Isbogrel
10684:Selenium
10652:Tropesin
10627:SC-58125
10612:Satigrel
10577:NCX-4040
10553:L-670596
10548:L-655240
10508:Curcumin
10370:Flunixin
10365:Clonixin
10304:Isoxicam
10299:Enolicam
10294:Droxicam
10272:Isopyrin
10267:Dipyrone
10188:Suprofen
10163:Naproxen
10113:Fenbufen
10056:Tolmetin
10046:Sulindac
9981:Felbinac
9976:Etodolac
9936:Bendazac
9749:Tiaprost
9569:Ataprost
9557:Unsorted
9503:Ridogrel
9475:ONO-3708
9460:L-670596
9455:L-655240
9430:GR-32191
9046:Aganepag
9028:Unsorted
9014:L-161982
8994:TCS-2510
8937:L-798106
8822:TG 4-155
8745:SC-51322
8740:SC-51089
8735:SC-19220
8730:ONO-8130
8566:AZD-1981
8561:ADC-3680
8432:Receptor
8309:Ketamine
8188:Funapide
8183:DSP-2230
8043:Nabilone
8038:Cannabis
7942:Ampyrone
7714:Tolmetin
7709:Sulindac
7686:Etodolac
7664:Acetates
7635:Isoxicam
7609:Suprofen
7599:Naproxen
7473:+codeine
7408:Tramadol
7403:Tilidine
7383:Propiram
7298:Fentanyl
7278:Dezocine
7227:Thebacon
7199:+aspirin
7142:+aspirin
7040:Laudanum
7025:Morphine
7013:+aspirin
6854:Naproxen
6819:Felbinac
6799:Bendazac
6783:Tolmetin
6634:category
6395:(coxibs)
6345:Flunixin
6325:Clonixin
6259:Suprofen
6233:Naproxen
6180:Fenbufen
6104:Isoxicam
6099:Droxicam
6071:Tolmetin
6066:Tiopinac
6061:Sulindac
6026:Isoxepac
6001:Felbinac
5996:Etodolac
5964:Bendazac
5796:Morazone
5781:Kebuzone
5751:Ampyrone
5535:Collagen
5525:Caffeine
5226:Mequinol
5145:Coal tar
4927:template
4908:12985124
4900:18568659
4857:15 March
4851:Archived
4827:15 March
4821:Archived
4730:Archived
4700:Archived
4675:23 April
4669:Archived
4638:Archived
4626:18476752
4579:21170569
4571:17216161
4508:15145225
4464:15145224
4412:Archived
4389:16435886
4325:Archived
4296:Archived
4292:BBC News
4274:18727958
4229:17148382
4180:16146840
4172:14745453
4127:31 March
4121:Archived
4097:23 April
4091:Archived
4066:Archived
3976:25963327
3880:11906715
3845:11588175
3796:22943167
3758:16806078
3618:20470236
3581:23 April
3575:Archived
3571:27014880
3538:23 April
3532:Archived
3528:25078485
3494:10773497
3452:32491802
3358:Archived
3336:75173071
3300:11992745
3232:11496855
3197:20530789
3148:16645966
3104:Archived
3074:Archived
3070:BBC News
3052:16740558
2985:Archived
2942:Archived
2913:23726390
2841:Archived
2819:20210866
2776:26 April
2745:28516471
2668:Archived
2642:17644321
2607:Archived
2559:16 April
2553:Archived
2524:16 April
2515:archived
2485:34271379
2434:25405963
2373:ClinCalc
2347:Archived
2343:ClinCalc
2268:74032271
2171:Archived
1927:Archived
1890:necrosis
1831:ungulate
1744:27649472
1675:Novartis
1505:enzymes.
1364:naproxen
1274:such as
1244:rhinitis
981:rectally
971:such as
957:Voltaren
855:(verify)
526:DrugBank
212:ATC code
158:category
140:DailyMed
10856:U63557A
10821:Ozagrel
10632:Tenidap
10572:NCX-466
10518:FK-3311
10513:DuP-697
10399:Bucetin
9926:Amfenac
9879:Salicin
9548:TRA-418
9395:AA-2414
9385:12-HETE
9370:U-46619
9304:TRA-418
9261:MRE-269
8812:AH-6809
8725:AH-6809
8611:TM30089
8591:QAV-680
8586:MK-7246
8581:MK-1029
8438:ligands
8314:Menthol
8289:Camphor
8166:(e.g.,
8159:Nefopam
8144:cocaine
8142:(e.g.,
7891:Salicin
7628:Oxicams
7453:Bucetin
7425:Viminol
7163:Metopon
7008:Codeine
6996:Opiates
6987:Opioids
6696:Topical
6644:commons
6545:Tenidap
6309:acids (
6146:profens
6086:oxicams
5959:Amfenac
5908:Salicin
5722:, also
5652:(e.g.,
5572:(e.g.,
5507:(e.g.,
5303:(e.g.,
5200:(e.g.,
4929:below (
4796:8 April
4644:15 July
4606:Bibcode
4488:Bibcode
4444:Bibcode
4380:1351921
4220:1618889
4152:Bibcode
3967:4445819
3924:9803699
3916:6628528
3836:6763876
3723:9626023
3688:3085490
3653:3085488
3425:8265610
3393:Bibcode
3156:2082359
3080:21 June
3043:1473048
2904:3778977
2736:6481688
2465:Bibcode
2425:4213586
1780:vulture
1657:History
1634:(ASICs)
1475:sodium.
1471:NSAIDs.
1419:death (
1405:aspirin
1301:Severe
1292:III/IV)
1284:Severe
1252:aspirin
1149:tablets
730:Formula
535:DB00586
481:PubChem
325:WARNING
297::
252: (
250:S01BC03
242: (
240:M02AA15
232: (
230:M01AB05
228:)
222: (
220:D11AX18
205:topical
171: C
142::
118:a689002
11003:Haleon
10953:Portal
10869:Others
10718:HQL-79
10622:SC-560
10617:SC-236
10582:NS-398
9783:Enzyme
9425:EP-045
9390:13-APA
9330:TP (TX
9266:NS-304
9226:AFP-07
8353:WHO-EM
8267:Others
7979:Others
7965:
7914:
7740:
7694:
7584:
7571:
7563:
7530:NSAIDs
7411:
7191:
7130:
7102:
7074:
6654:portal
5488:Others
5401:Others
5160:Sulfur
4981:Other
4946:Curlie
4932:Curlie
4906:
4898:
4632:
4624:
4577:
4569:
4506:
4462:
4418:28 May
4387:
4377:
4331:12 May
4272:
4227:
4217:
4178:
4170:
4144:Nature
4062:
4038:
4015:
3974:
3964:
3922:
3914:
3878:
3843:
3833:
3794:
3756:
3721:
3686:
3651:
3616:
3569:
3526:
3492:
3450:
3423:
3413:
3334:
3320:Nature
3298:
3230:
3195:
3154:
3146:
3050:
3040:
2911:
2901:
2883:Lancet
2817:
2743:
2733:
2640:
2483:
2432:
2422:
2321:
2295:
2266:
2229:
2163:
2016:8 June
1835:rabies
1742:
1663:dichlo
1492:Kidney
1416:coxibs
1051:
1030:, and
1024:stroke
977:orally
804:SMILES
771:296.15
626:ChEMBL
595:D07816
427:, 65%
409:1.2–2
382:) and
380:UGT2B7
372:CYP3A4
368:CYP2C8
364:CYP2C9
322:
309:
299:℞-only
285:
193:rectal
189:Orally
138:
87:others
9508:S-145
9357:I-BOP
9202:IP (I
9105:FP (F
8631:EP (E
8450:DP (D
7441:-type
7328:NFEPP
7035:Opium
7000:opium
6911:Other
6792:Other
6700:joint
6603:Key:
6554:NSAID
6473:other
5724:N02BA
4904:S2CID
4630:S2CID
4575:S2CID
4531:Texte
4527:(PDF)
4176:S2CID
3946:Drugs
3920:S2CID
3416:48050
3332:S2CID
3152:S2CID
2938:(FDA)
2934:U.S.
2766:(WHO)
2696:(PDF)
2685:(PDF)
2518:(PDF)
2511:(PDF)
2264:S2CID
1710:use.
1598:COX-1
1572:COX-2
1551:COX-2
1547:COX-1
1457:Liver
1387:Heart
1240:shock
1070:treat
1003:with
983:as a
824:InChI
780:JSmol
653:DIF (
606:ChEBI
429:urine
10769:TXAS
10727:PGFS
10708:PGES
9806:PTGS
6978:N02B
6974:N02A
6702:and
5720:M02A
5718:and
5716:M01A
5165:Urea
4896:PMID
4859:2023
4829:2023
4798:2021
4768:2024
4738:2024
4708:2018
4677:2023
4646:2019
4622:PMID
4567:PMID
4504:PMID
4460:PMID
4420:2014
4385:PMID
4333:2006
4304:2010
4270:PMID
4225:PMID
4168:PMID
4129:2015
4099:2023
4036:ISBN
4013:ISSN
3972:PMID
3912:PMID
3876:PMID
3841:PMID
3792:PMID
3754:PMID
3719:PMID
3684:PMID
3649:PMID
3614:PMID
3583:2023
3567:PMID
3540:2023
3524:PMID
3490:PMID
3459:2024
3448:PMID
3421:PMID
3366:2013
3296:PMID
3228:PMID
3193:PMID
3144:PMID
3112:2015
3082:2018
3048:PMID
2993:2020
2950:2020
2909:PMID
2849:2015
2815:PMID
2778:2020
2741:PMID
2719:2017
2638:PMID
2561:2022
2526:2022
2481:PMID
2430:PMID
2380:2024
2355:2024
2319:ISBN
2293:ISBN
2227:ISBN
2206:2024
2179:2023
2161:ISBN
2130:2024
2084:2024
2049:2024
2018:2024
1990:2023
1961:2024
1935:2018
1826:Gyps
1813:Gyps
1740:PMID
1667:phen
1549:and
1537:and
1362:and
1290:NYHA
1184:and
1095:and
1073:pain
973:gout
967:and
965:pain
656:PDBe
586:KEGG
566:UNII
555:2925
515:2714
495:3033
425:bile
423:35%
342:data
94:AHFS
10746:PGI
10663:PGD
9801:COX
6708:M02
4987:D11
4944:at
4886:doi
4614:doi
4559:doi
4555:387
4496:doi
4452:doi
4375:PMC
4365:doi
4260:hdl
4252:doi
4248:149
4215:PMC
4207:doi
4160:doi
4148:427
4003:doi
3962:PMC
3954:doi
3904:doi
3868:doi
3864:438
3831:PMC
3823:doi
3784:doi
3746:doi
3742:346
3711:doi
3707:104
3676:doi
3641:doi
3606:doi
3563:107
3520:105
3482:doi
3411:PMC
3401:doi
3324:doi
3286:doi
3220:doi
3216:345
3183:doi
3136:doi
3038:PMC
3030:doi
3026:332
3022:BMJ
2899:PMC
2891:doi
2887:382
2805:doi
2731:PMC
2723:doi
2630:doi
2473:doi
2461:796
2420:PMC
2412:doi
2408:369
2256:doi
2153:doi
1983:FDA
1851:in
1617:COX
1543:COX
1278:or
1265:or
911:or
679:EPA
485:CID
311:POM
255:WHO
248:),
245:WHO
238:),
235:WHO
225:WHO
10979::
10694:,
10690:,
10493:;
10421:;
10384:;
10372:;
10355:;
10343:;
10326:;
10284:;
10257:;
10210:;
10068:;
9906:;
9332:A2
9169:2α
9107:2α
9078:2α
8948:EP
8833:EP
8756:EP
8649:EP
8525:DP
8468:DP
8366::
8176:Na
8146:,
7417:,
7209:,
7205:,
7201:,
7197:,
7140:,
7136:,
6976:,
6615:;
6611:;
6293::
4902:.
4894:.
4882:37
4880:.
4876:.
4845:.
4815:.
4784:.
4754:.
4728:.
4724:.
4698:.
4694:.
4667:.
4663:.
4636:.
4628:.
4620:.
4612:.
4602:27
4600:.
4596:.
4573:.
4565:.
4553:.
4535:29
4529:.
4502:.
4494:.
4484:68
4482:.
4458:.
4450:.
4440:68
4438:.
4410:.
4406:.
4383:.
4373:.
4359:.
4355:.
4341:^
4312:^
4290:.
4268:.
4258:.
4246:.
4223:.
4213:.
4201:.
4197:.
4174:.
4166:.
4158:.
4146:.
4119:.
4115:.
4089:.
4085:.
4011:.
3999:36
3997:.
3993:.
3970:.
3960:.
3950:75
3948:.
3944:.
3932:^
3918:.
3910:.
3900:25
3898:.
3874:.
3862:.
3839:.
3829:.
3819:21
3817:.
3813:.
3790:.
3780:64
3778:.
3766:^
3752:.
3740:.
3717:.
3705:.
3682:.
3672:80
3670:.
3647:.
3637:80
3635:.
3612:.
3602:26
3600:.
3573:.
3561:.
3557:.
3530:.
3518:.
3514:.
3502:^
3488:.
3478:14
3476:.
3442:.
3419:.
3409:.
3399:.
3389:90
3387:.
3383:.
3356:.
3352:.
3330:.
3322:.
3308:^
3294:.
3282:23
3280:.
3276:.
3264:^
3248:.
3226:.
3214:.
3191:.
3177:.
3173:.
3150:.
3142:.
3132:54
3130:.
3098:.
3068:.
3046:.
3036:.
3024:.
3020:.
2979:.
2968:^
2932:.
2921:^
2907:.
2897:.
2885:.
2881:.
2857:^
2839:.
2835:.
2813:.
2801:11
2799:.
2795:.
2761:.
2739:.
2729:.
2717:.
2713:.
2687:.
2666:.
2662:.
2658:.
2636:.
2626:30
2624:.
2605:.
2601:.
2572:^
2563:.
2551:.
2547:.
2533:^
2493:^
2479:.
2471:.
2459:.
2442:^
2428:.
2418:.
2406:.
2402:.
2388:^
2371:.
2345:.
2341:.
2276:^
2262:.
2250:.
2169:.
2159:.
2119:.
2092:^
2075:.
2037:.
2026:^
2006:.
1981:.
1977:.
1951:.
1925:.
1921:.
1908:^
1863:.
1685:.
1671:ac
1669:yl
1653:.
1533:,
1444:,
1430:.
1335:,
1246:,
1242:,
1238:,
1186:IM
1182:IV
1126:.
1118:.
1091:,
1083:,
1079:,
1026:,
1022:,
1014:,
889:oʊ
877:aɪ
747:Cl
744:11
738:14
659:,
370:,
318:US
305:UK
294:CA
287:S4
281:AU
203:,
199:,
195:,
191:,
167:AU
135:US
10955::
10914:2
10906:2
10750:S
10748:2
10698:)
10686:(
10667:S
10665:2
10567:)
10565:2
9808:)
9804:(
9791:)
9787:(
9492:2
9364:2
9351:2
9334:)
9282:1
9273:2
9206:)
9204:2
9161:2
9109:)
9040:2
8987:2
8978:1
8950:4
8910:2
8901:1
8893:2
8835:3
8795:2
8786:1
8758:2
8708:2
8699:1
8651:1
8635:)
8633:2
8550:2
8527:2
8488:2
8470:1
8454:)
8452:2
8440:)
8436:(
8410:e
8403:t
8396:v
8178:v
8170:)
8150:)
7971:)
7967:(
7920:)
7916:(
7827:)
7823:(
7746:)
7742:(
7700:)
7696:(
7590:)
7586:(
7577:)
7573:(
7569:)
7565:(
7421:)
7413:(
7304:)
7300:(
7213:)
7193:(
7144:)
7132:(
7108:)
7104:(
7080:)
7076:(
7031:)
7027:(
6998:/
6980:)
6972:(
6962:e
6955:t
6948:v
6710:)
6706:(
6688:e
6681:t
6674:v
6619:.
6415:)
6411:(
6313:)
6305:n
6148:)
5735:/
5726:)
5704:e
5697:t
5690:v
5656:)
5576:)
5511:)
5307:)
5204:)
5171:)
5167:(
5051:)
5047:(
4989:)
4974:e
4967:t
4960:v
4910:.
4888::
4861:.
4831:.
4800:.
4770:.
4740:.
4710:.
4679:.
4648:.
4616::
4608::
4581:.
4561::
4510:.
4498::
4490::
4466:.
4454::
4446::
4422:.
4391:.
4367::
4361:4
4335:.
4306:.
4276:.
4262::
4254::
4231:.
4209::
4203:2
4182:.
4162::
4154::
4131:.
4101:.
4044:.
4019:.
4005::
3978:.
3956::
3926:.
3906::
3882:.
3870::
3847:.
3825::
3798:.
3786::
3760:.
3748::
3725:.
3713::
3690:.
3678::
3655:.
3643::
3620:.
3608::
3585:.
3542:.
3496:.
3484::
3461:.
3427:.
3403::
3395::
3368:.
3338:.
3326::
3302:.
3288::
3234:.
3222::
3199:.
3185::
3179:3
3158:.
3138::
3114:.
3084:.
3054:.
3032::
3006:.
2995:.
2963:.
2952:.
2915:.
2893::
2851:.
2821:.
2807::
2780:.
2747:.
2725::
2644:.
2632::
2487:.
2475::
2467::
2436:.
2414::
2382:.
2357:.
2327:.
2301:.
2270:.
2258::
2252:9
2235:.
2208:.
2181:.
2155::
2132:.
2086:.
2062:.
2051:.
2020:.
1992:.
1963:.
1937:.
1760:)
1756:(
1752:.
1746:.
1647:h
1440:(
1288:(
951:/
948:k
945:æ
942:n
939:ɛ
936:f
933:ˈ
930:ɒ
927:l
924:k
921:ɪ
918:d
915:/
907:/
904:k
901:æ
898:n
895:ə
892:f
886:l
883:k
880:ˈ
874:d
871:/
782:)
759:2
756:O
753:N
750:2
741:H
735:C
681:)
677:(
665:)
411:h
378:(
320::
307::
283::
258:)
169::
96:/
41:.
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
