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Kearney, P. N.; Nowak, M. W.; Zhong, W.; Silverman, S. K.; Lester, H. A.; Dougherty, D. A. (Nov 1996). "Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists".
237:
Dougherty is the recipient of multiple teaching awards including the
Richard Badger Teaching Award (1992), the ASCIT Excellence in Teaching Award (1987 and 2000), and the Richard P. Feynman Prize for Excellence in Teaching (2010). In 2009, he was elected to the
709:
Beene, D. B.; Brandt, G. S.; Zhong, W.; Zacharias, N. M.; Lester, H. A.; Dougherty, D. A. (Aug 2002). "Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine".
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In 1979 Dougherty became a member of the
Caltech faculty, earning tenure in 1985. He is the scientific co-founder of Neurion Pharmaceuticals, Inc. In 2005 he published a textbook entitled
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to systems of biological importance. Dougherty utilizes a variety of approaches to further our understanding of the human brain, including the
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398:"Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type a receptor that contributes to the gating pathway"
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Dougherty, D. A.; Stauffer, D. A. (Dec 1990). "Acetylcholine binding by a synthetic receptor: implications for biological recognition".
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Beene, D. D.; Dougherty, D. A.; Lester, H. A. (Jun 2003). "Unnatural amino acid mutagenesis in mapping ion channel function".
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605:"A fluorophore attached to nicotinic acetylcholine receptor βM2 detects productive binding of agonist to the αδ site"
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Dahan, S.; Dibas, I.; Petersson, J.; Auyeung, C.; Chanda, B.; Bezanilla, F.; Dougherty, A.; Lester, A. (Jul 2004).
847:"Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position"
749:"From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor"
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562:"A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors"
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441:"In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression"
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He currently lives in South
Pasadena with his wife Dr. Ellen Dougherty, the superintendent of the
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265:"A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor"
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502:"Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel"
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Zhong, W.; Gallivan, J. P.; Zhang, Y.; Li, L.; Lester, H. A.; Dougherty, D. A. (Oct 1998).
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nonsense suppression methodology for incorporating unnatural amino acids into a variety of
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Lummis, C.; Beene, L.; Lee, W.; Lester, A.; Broadhurst, W.; Dougherty, A. (Nov 2005).
1094:"Richard P. Feynman Prize for Excellence in Teaching - Caltech Office of the Provost"
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Kearney, P. C.; Zhang, H.; Zhong, W.; Dougherty, D. A.; Lester, H. A. (Dec 1996).
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the
National Academy of Sciences of the United States of America
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Dougherty, A. (May 2008). "Cys-loop neuroreceptors: structure to the rescue?".
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Ma, J. C.; Dougherty, D. A. (Aug 1997). "The
Cationminus signpi Interaction".
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Fellow of the
American Association for the Advancement of Science (1994)
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202:. Subsequently, he earned his Ph.D. in 1978 under the supervision of
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Xiu, X.; Hanek, P.; Wang, J.; Lester, A.; Dougherty, A. (Dec 2005).
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ACS James Flack Norris Award in
Physical Organic Chemistry (2008)
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Richard P. Feynman Prize for
Excellence in Teaching (2010)
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Fellow of the American Academy of Arts and Sciences (1999)
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Richard P. Feynman Prize for Excellence in Teaching (2010)
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Members of the United States National Academy of Sciences
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Camille and Henry Dreyfus Teacher-Scholar (1984–1989)
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Rodriguez, A.; Lester, A.; Dougherty, A. (Jun 2006).
174:) is the George Grant Hoag Professor of Chemistry at
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American Association for the Advancement of Science
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198:Dougherty received his B.S. and M.S. in 1974 from
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263:Hanek, P.; Lester, A.; Dougherty, A. (Oct 2008).
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980:AstraZeneca Excellence in Chemistry Award (1991)
396:Wang, J.; Lester, A.; Dougherty, A. (Sep 2007).
986:Javits Neuroscience Investigator, NIH (2004)
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346:"Physical organic chemistry on the brain"
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272:Journal of the American Chemical Society
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1073:The California Institute of Technology
1144:"Lawndale Elementary School District"
1211:People from Harrisburg, Pennsylvania
1050:Lawndale Elementary School District
1033:National Academy of Sciences (2009)
983:Arthur C. Cope Scholar Award (1992)
566:The Journal of Biological Chemistry
402:The Journal of Biological Chemistry
210:and was a post-doctoral scholar in
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1119:"72 New Members Chosen By Academy"
176:California Institute of Technology
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228:Modern Physical Organic Chemistry
16:American physical organic chemist
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353:The Journal of Organic Chemistry
190:for structure-function studies.
666:Current Opinion in Neurobiology
1201:21st-century American chemists
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1:
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864:10.1016/S0896-6273(00)80252-4
678:10.1016/S0959-4388(03)00068-0
1181:Dennis A. Dougherty lab page
240:National Academy of Sciences
193:
7:
166:(born December 4, 1952, in
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344:Dougherty, A. (May 2008).
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180:physical organic chemistry
1069:"Caltech Today - Caltech"
1014:American Chemical Society
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1123:8.nationa.lacademies.org
1029:Society for Neuroscience
1003:Professional memberships
774:10.1073/pnas.95.21.12088
178:. His research applies
46:Harrisburg, Pennsylvania
940:10.1126/science.2274786
630:10.1073/pnas.0301885101
466:10.1073/pnas.0510817103
891:Molecular Pharmacology
579:10.1074/jbc.M508635200
415:10.1074/jbc.M702314200
1176:Dougherty Lab Website
257:Selected publications
252:cation–pi interaction
996:Arthur C. Cope Award
246:Cation-π Interaction
208:Princeton University
100:Arthur C. Cope Award
89:post-doctoral (1979)
79:Princeton University
1098:Provost.caltech.edu
1024:Biophysical Society
932:1990Sci...250.1558D
926:(4987): 1558–1560.
765:1998PNAS...9512088Z
759:(21): 12088–12093.
718:(32): 10262–10269.
621:2004PNAS..10110195D
615:(27): 10195–10200.
572:(50): 41655–41666.
529:10.1038/nature04130
521:2005Natur.438..248L
457:2006PNAS..103.8650R
408:(36): 26210–26216.
278:(40): 13216–13218.
200:Bucknell University
164:Dennis A. Dougherty
67:Bucknell University
23:Dennis A. Dougherty
152:Lisa McElwee-White
1186:Caltech Chemistry
822:10.1021/cr9603744
724:10.1021/bi020266d
515:(7065): 248–252.
451:(23): 8650–8655.
365:10.1021/jo8001722
359:(10): 3667–3673.
321:10.1021/cr078207z
284:10.1021/ja8015457
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148:Doctoral students
138:Academic advisors
108:Scientific career
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63:Alma mater
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1206:1952 births
204:Kurt Mislow
142:Kurt Mislow
53:Nationality
1195:Categories
1154:2010-06-19
1056:References
214:'s lab at
168:Harrisburg
35:1952-12-04
1128:10 August
1103:10 August
1078:10 August
948:0036-8075
903:0026-895X
873:0896-6273
830:0009-2665
783:0027-8424
732:0006-2960
686:0959-4388
639:0027-8424
588:0021-9258
537:0028-0836
475:0027-8424
424:0021-9258
373:0022-3263
329:0009-2665
292:0002-7863
218:in 1979.
194:Education
118:Chemistry
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838:11851453
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300:18781739
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881:8982168
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617:Bibcode
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184:in vivo
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82:Ph.D
29:Born
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