1185:
566:
1472:
439:
453:
701:
819:
550:
897:
965:
1085:
1253:
5684:
5672:
1423:, due to the associated muscle and joint pains. In the report title he uses the more formal term "bilious remitting fever". The term dengue fever came into general use only after 1828. Other historical terms include "breakheart fever" and "la dengue". Terms for severe disease include "infectious thrombocytopenic purpura" and "Philippine", "Thai", or "Singapore hemorrhagic fever".
49:
947:
Ideally, mosquito control would be a community activity, e.g. when all members of a community clear blocked gutters and street drains and keep their yards free of containers with standing water. If residences have direct water connections this eliminates the need for wells or street pumps and water-carrying containers.
1352:
has been attributed partly to disruption caused by the war, and partly to subsequent urbanisation in south-east Asia. As novel serotypes were introduced to regions already endemic with dengue, outbreaks of severe disease followed. The severe hemorrhagic form of the disease was first reported in the
412:
have been approved and are commercially available. Dengvaxia became available in 2016 but it is only recommended to prevent re-infection in individuals who have been previously infected. The second vaccine, Qdenga, became available in 2022 and is suitable for adults, adolescents and children from
1169:
Most people with dengue recover without any ongoing problems. The risk of death among those with severe dengue is 0.8–2.5%, and with adequate treatment this is less than 1%. However, those who develop significantly low blood pressure may have a fatality rate of up to 26%. The risk of death among
910:
The principal risk for infection with dengue is the bite of an infected mosquito. This is more probable in areas where the disease is endemic, especially where there is high population density, poor sanitation, and standing water where mosquitoes can breed. It can be mitigated by taking steps to
790:
The principal risk for infection with dengue is the bite of an infected mosquito. This is more probable in areas where the disease is endemic, especially where there is high population density, poor sanitation, and standing water where mosquitoes can breed. It can be mitigated by taking steps to
476:
The characteristic symptoms of mild dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, nausea, vomiting, swollen glands and a rash. If this progresses to severe dengue the symptoms are severe abdominal pain, persistent vomiting, rapid breathing,
1234:
in more than 100 countries with cases reported in every continent with the exception of
Antarctica. The Americas, Southeast Asia and the Western Pacific regions are the most seriously affected. It is difficult to estimate the full extent of the disease, as many cases are mild and not correctly
946:
insecticides, while sometimes done, is not thought to be effective. Reducing open collections of water through environmental modification is the preferred method of control, given the concerns of negative health effects from insecticides and greater logistical difficulties with control agents.
882:
decreases, and the blood pressure becomes so low that it cannot supply sufficient blood to vital organs. The spread of the virus to the bone marrow leads to reduced numbers of platelets, which are necessary for effective blood clotting; this increases the risk of bleeding, the other major
975:(formerly CYD-TDV) became available in 2015, and is approved for use in the US, EU and in some Asian and Latin American countries. It is an attenuated virus, is suitable for individuals aged 6–45 years and protects against all four serotypes of dengue. Due to safety concerns about
826:
The exact mechanism of ADE is not fully understood. It appears that ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they fail to neutralize it. Instead, the antibody-virus complex has an enhanced ability to bind to the
1294:
Dengue has increased in incidence in recent decades, with WHO recording a ten fold increase between 2010 and 2019 (from 500,000 to 5 million recorded cases). This increase is tied closely to the increasing range of Aedes mosquitoes, which is attributed to a combination of
1364:
In
Central and South America, the Aedes mosquito had been eradicated in the 1950s; however the eradication program was discontinued in the 1970s and the disease re-established itself in the region during the 1980s, becoming hyperendemic and causing significant epidemics.
766:
and is released into its saliva. Next time the mosquito feeds, the infectious saliva will be injected into the bloodstream of its victim, thus spreading the disease. The virus seems to have no detrimental effect on the mosquito, which remains infected for life.
811:, Infection with one serotype is thought to produce lifelong immunity to that type, but only short-term protection against the other three. Subsequent re-infection with a different serotype increases the risk of severe complications due to phenomenon known as
1092:
Warning symptoms of severe dengue include abdominal pain, persistent vomiting, odema, bleeding, lethargy, and liver enlargement. Once again, these symptoms can be confused with other diseases such as malaria, gastroenteritis, leptospirosis, and typhus.
918:
Protection of the home can be achieved with door and window screens, by using air conditioning, and by regularly emptying and cleaning all receptacles both indoors and outdoors which may accumulate water (such as buckets, planters, pools or trashcans).
1495:. Goals are to increase public awareness about dengue, mobilize resources for its prevention and control and, to demonstrate the Southeast Asian region's commitment in tackling the disease. Efforts are ongoing as of 2019 to make it a global event.
1235:
diagnosed. WHO currently estimates that 3.9 billion people are at risk of dengue infection. In 2013, it was estimated that 390 million dengue infections occur every year, with 500,000 of these developing severe symptoms and 25,000 deaths.
911:
avoid bites such as by wearing clothing that fully covers the skin, using mosquito netting while resting, and/or the application of insect repellent (DEET being the most effective); it is also advisable to treat clothing, nets and tents with 0.5%
381:
There is no specific treatment for dengue fever. In mild cases, treatment is focused on treating pain symptoms. Severe cases of dengue require hospitalisation; treatment of acute dengue is supportive and includes giving fluid either by mouth or
618:
985:(formerly TAK-003) completed clinical trials in 2022 and was approved for use in the European Union in December 2022; it has been approved by a number of other countries including Indonesia and Brazil, and has been recommended by the
3987:
989:
of the World Health
Organization. It is indicated for the prevention of dengue disease in individuals four years of age and older, and can be administered to people who have not been previously infected with dengue. It is a live
866:, which are responsible for many of the symptoms, such as the fever, the flu-like symptoms, and the severe pains. In severe infection, the virus production inside the body is greatly increased, and many more organs (such as the
1368:
Dengue has continued to increase in prevalence during the 21st century, as the mosquito vector continues to expand its range. This is attributed partly to continuing urbanisation, and partly to the impact of a warmer climate.
3793:
425:. During 2023, more than 5 million infections were reported, with more than 5,000 dengue-related deaths. As most cases are asymptomatic or mild, the actual numbers of dengue cases and deaths are under-reported.
761:
period). A female mosquito that takes a blood meal from the infected host then propagates the virus in the cells lining its gut. Over the next few days, the virus spreads to other tissues including the mosquito's
420:
in more than one hundred countries, dengue is spreading from tropical and subtropical regions to the
Iberian Peninsula and the southern states of the US, partly attributed to climate change. It is classified as a
5549:
5534:
5511:
1088:
Graph of when laboratory tests for dengue fever become positive. Day zero refers to the start of symptoms, 1st refers to in those with a primary infection, and 2nd refers to in those with a secondary infection.
806:
Chronic diseases – such as asthma, sickle cell anemia, and diabetes mellitus – increase the risk of developing a severe form of the disease. Other risk factors for severe disease include female sex, and high
357:
to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. The symptoms of dengue resemble many other diseases including
507:). Severe dengue can lead to shock, internal bleeding, organ failure and even death. Warning signs include severe stomach pain, vomiting, difficulty breathing, and blood in the nose, gums, vomit or stools.
979:(ADE), it should only be given to individuals who have previously been infected with dengue, in order to protect them from reinfection. It is given subcutaneously as three doses at six month intervals.
492:(40 °C/104 °F), and is associated with generalized pain and a headache; this usually lasts two to seven days. There may also be nausea, vomiting, a rash, and pains in the muscle and joints.
3375:
822:
In antibody-dependent enhancement (ADE), antibodies bind to both viral particles and Fc gamma receptors expressed on immune cells, increasing the likelihood that the viruses will infect those cells.
3929:
1277:. This species has adapted to the urban environment, is generally found close to human habitation, prefers humans as its host, and takes advantage of small bodies of standing water (such as
3957:
3783:
3665:
5479:
3698:
1348:
in many tropical urban centres throughout the 19th and early 20th centuries, even though significant outbreaks were infrequent. The marked spread of dengue during and after the
4215:
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP (April 2013).
3731:
3488:
3040:
1329:
and consequent expansion of international trading. There have been descriptions of epidemics of dengue-like illness in the 17th century, and it is likely that epidemics in
4020:
586:
following severe dengue include fatigue, somnolence, headache, concentration impairment and memory impairment. A pregnant woman who develops dengue is at higher risk of
1306:
The disease infects all races, sexes, and ages equally. In endemic areas, the infection is most commonly seen in children who then acquire a lifelong partial immunity.
2510:
6775:
3405:
3224:
2858:
2155:
839:
When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. The virus infects nearby skin cells called
2800:
3600:
1483:
International Anti-Dengue Day is observed every year on 15 June in a number of countries. The idea was first agreed upon in 2010 with the first event held in
1146:
For moderate illness, those who can drink, are passing urine, have no warning signs and are otherwise reasonably healthy can be monitored carefully at home.
469:(80%) or have only mild symptoms such as an uncomplicated fever. Others have more severe illness (5%), and in a small proportion it is life-threatening. The
4495:
3367:
5251:
1401:
referring to the dislike of movement by affected patients. Slaves in the West Indies having contracted dengue were said to have the posture and gait of a
1463:
due to potential infection with the virus. Someone who has a dengue infection is typically not allowed to donate blood for at least the next six months.
5369:
4750:
3854:
2371:
1737:
1588:
1170:
children less than five years old is four times greater than among those over the age of 10. Elderly people are also at higher risk of a poor outcome.
3921:
3823:
1073:
by more than one disease. For travellers, dengue fever diagnosis should be considered in anyone who develops a fever within two weeks of being in the
5716:
3101:
2000:
1858:
2923:
2841:
1776:
6531:
5331:
4344:
4087:
3002:
2692:
1017:
Severe dengue can develop suddenly, sometimes after a few days as the fever subsides. Leakage of plasma from the capillaries results in extreme
5484:
4521:
2620:
1963:
3575:
2268:
6785:
3761:
416:
The earliest descriptions of a dengue outbreak date from 1779; its viral cause and spread were understood by the early 20th century. Already
3194:
1930:
1518:
1104:; however this antigen is produced by all flaviviruses. Four or five days into the infection, it is possible to reliably detect anti-dengue
3657:
1718:
6160:
5007:
4930:
4380:
3079:
2778:
2304:
684:
and seven other protein molecules that are required for replication of the virus. There are four confirmed strains of the virus, called
4976:
3687:
1435:(the process by which the disease develops in humans), as well as the biology, ecology and behaviour of the mosquito vector. Improved
2033:
4054:
3522:
1268:
in areas where more than one serotype is circulating; this increases the risk of severe disease on a second or subsequent infection.
1096:
Blood tests can be used to confirm a diagnosis of dengue. During the first few days of infection, enzyme-linked immunosorbent assay (
477:
bleeding gums or nose, fatigue, restlessness, blood in vomit or stool, extreme thirst, pale and cold skin, and feelings of weakness.
4904:
4709:
4691:
4395:
3480:
3032:
2330:
3896:
3723:
1007:
1123:
Most cases of dengue fever have mild symptoms, and recovery takes place in a few days. No treatment is required for these cases.
5797:
5309:
874:) can be affected. Fluid from the bloodstream leaks through the wall of small blood vessels into body cavities due to increased
4012:
1670:
1153:
Severe dengue is a life-threatening emergency, requiring hospitalization and potentially intensive care. Warning signs include
495:
Most people recover within a week or so. In about 5% of cases, symptoms worsen and can become life-threatening. This is called
117:
4322:
3635:
6993:
5709:
5285:
5001:
4970:
4374:
3890:
3188:
3073:
2835:
2772:
2592:
2298:
1712:
1413:
1271:
Infections are most commonly acquired in urban environments where the virus is primarily transmitted by the mosquito species
6034:
5391:
2502:
1895:
533:
The recovery phase usually lasts two to three days. The improvement is often striking, and can be accompanied with severe
6149:
5564:
2862:
986:
757:
For 2 to 10 days after becoming newly infected, a person's bloodstream will contain a high level of virus particles (the
3397:
3216:
2792:
2147:
1264:
Generally, areas where dengue is endemic have only one serotype of the virus in circulation. The disease is said to be
1689:
1041:. Severe dengue is a medical emergency which can cause damage to organs, leading to multiple organ failure and death.
6024:
5021:
Laughlin CA, Morens DM, Cassetti MC, Costero-Saint Denis A, San Martin JL, Whitehead SS, Fauci AS (1 October 2012).
994:
vaccine containing the four serotypes of dengue virus, administered subcutaneously as two doses three months apart.
571:
The rash that commonly forms during the recovery from dengue fever with its classic islands of white in a sea of red
6536:
6376:
5909:
5904:
5702:
3592:
622:
6983:
6311:
5255:
976:
812:
724:. They prefer to feed at dusk and dawn, but they may bite and thus spread infection at any time of day. Other
688:, referred to as DENV-1, DENV-2, DENV-3 and DENV-4. The distinctions between the serotypes are based on their
6568:
6208:
5807:
5361:
3846:
3784:"Message by the Director of the Department of Immunization, Vaccines and Biologicals at WHO - September 2023"
1733:
1479:, Singapore, notifying people that there are ten or more cases of dengue in the neighbourhood (November 2015)
1314:
The first historical record of a case of probable dengue fever is in a
Chinese medical encyclopedia from the
20:
1580:
1446:
In addition to the two vaccines which are already available, several vaccine candidates are in development.
6859:
6854:
6462:
3815:
1985:
4850:
Christie J. On
Epidemics of Dengue Fever: Their Diffusion and Etiology. Glasgow Med J. 1881;16(3):161-176.
3093:
1850:
1377:
The name came into
English in the early 19th century from West Indian Spanish, which borrowed it from the
473:(time between exposure and onset of symptoms) ranges from 3 to 14 days, but most often it is 4 to 7 days.
6489:
6484:
6472:
6014:
5897:
2885:
2822:
1768:
5339:
5022:
1459:
Outbreaks of dengue fever increase the need for blood products while decreasing the number of potential
1014:
is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage.
326:. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into
6988:
6578:
6496:
6477:
5843:
5662:
2183:
422:
4814:
1779–1780: 'Knokkel-koorts' in
Batavia (now Jakarta, Indonesia) and 'break bone fever' in Philadelphia
4076:
3006:
2643:
1184:
6701:
6164:
6056:
3788:
1315:
1003:
2532:
Kalimuddin S, Teh YE, Wee LE, Paintal S, Sasisekharan R, Low JG, Sheth SK, Ooi EE (18 August 2022).
1955:
961:
As of March 2024, there are two vaccines to protect against dengue infection; Dengvaxia and Qdenga.
510:
During this period, there is leakage of plasma from the blood vessels, together with a reduction in
6780:
6723:
6601:
6396:
5921:
5575:
3545:
2238:
3753:
831:
receptors of the target immune cells, enabling the virus to infect the cell and reproduce itself.
565:
6884:
6546:
6541:
6446:
6241:
6227:
6203:
6145:
5955:
5839:
4161:
3880:
3170:
1922:
935:
302:; if symptoms appear they typically begin 3 to 14 days after infection. These may include a high
134:
2534:"Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness"
6231:
6199:
6175:
6010:
5888:
5812:
5787:
5773:
5752:
4496:"Climate Change Will Expose Half of World's Population to Disease-Spreading Mosquitoes By 2050"
1702:
1523:
1345:
1179:
900:
A 1920s photograph of efforts to disperse standing water and thus decrease mosquito populations
875:
417:
408:. Infection can be prevented by mosquito elimination and the prevention of bites. Two types of
280:
206:
5626:
5524:
4991:
4922:
4362:
3063:
2762:
2286:
6978:
6664:
6573:
6551:
6215:
6124:
5892:
5694:
5520:
4826:
1147:
779:
5528:
4960:
6716:
6711:
6090:
4228:
3956:
Beltrán-Silva SL, Chacón-Hernández SS, Moreno-Palacios E, Pereyra-Molina JÁ (1 July 2018).
3310:"Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?"
3251:"Understanding antibody-dependent enhancement in dengue: Are afucosylated IgG1s a concern?"
2593:"Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis"
2025:
1471:
1397:
in
Spanish due to this word existing in Spanish with the meaning "fastidiousness" and this
1303:. In endemic areas, dengue infections peak when rainfall is optimal for mosquito breeding.
930:. This is done by eliminating open sources of water, or if this is not possible, by adding
233:
4861:
4648:
4046:
3955:
3514:
1393:: "a sort of cramp-like seizure (caused by) an evil spirit". The borrowed term changed to
8:
6637:
6506:
6301:
5553:
1049:
Mild cases of dengue fever can easily be confused with several common diseases including
736:
383:
343:
147:
6652:
5171:
5138:
4232:
3344:
3309:
3285:
3250:
2671:
1281:
and buckets) in which to breed. In rural settings the virus is transmitted to humans by
1161:. Treatment modes include intravenous fluids, and transfusion with platelets or plasma.
6849:
5976:
5223:
5198:
5114:
5079:
5055:
4896:
4891:
4800:
4774:"A re-examination of the history of etiologic confusion between dengue and chikungunya"
4773:
4683:
4678:
4477:
4257:
4216:
4142:
3456:
3431:
2979:
2946:
2915:
2738:
2713:
2684:
2568:
2533:
2475:
2421:
2216:
2129:
1824:
1799:
1650:
1509:
A study estimate that the global burden of dengue in 2013 amounted to US$ 8.9 billion.
1439:
would enable faster and more appropriate treatment. Attempts are ongoing to develop an
1326:
991:
677:
485:
The course of infection is divided into three phases: febrile, critical, and recovery.
354:
248:
124:
5434:
2902:
2608:
2117:
2104:
Paz-Bailey G, Adams LE, Deen J, Anderson KB, Katzelnick LC (February 2024). "Dengue".
2081:
2056:
1120:
As of July 2024, there is no specific antiviral treatment available for dengue fever.
452:
6998:
6929:
6706:
6049:
5863:
5586:
5446:
5438:
5301:
5281:
5228:
5214:
5176:
5158:
5119:
5101:
5060:
5042:
4997:
4966:
4805:
4742:
4629:
4624:
4599:
4569:
4481:
4469:
4428:
4370:
4338:
4303:
4262:
4244:
4134:
3979:
3886:
3567:
3461:
3349:
3331:
3290:
3272:
3184:
3146:
3069:
2984:
2966:
2919:
2907:
2831:
2768:
2743:
2676:
2612:
2573:
2555:
2467:
2413:
2396:
Chen LH, Wilson ME (October 2010). "Dengue and chikungunya infections in travelers".
2363:
2294:
2260:
2220:
2208:
2133:
2121:
2086:
1887:
1829:
1811:
1708:
1642:
1131:) may be used to relieve mild fever or pain. Other common pain relievers, including
1109:
1022:
742:
470:
252:
189:
112:
5558:
4900:
4687:
2479:
2450:
Ranjit S, Kissoon N (January 2011). "Dengue hemorrhagic fever and shock syndromes".
1667:
1069:
mosquitoes) and are often endemic in the same regions, so that it is possible to be
244:
6657:
6642:
6272:
6083:
6078:
5430:
5218:
5210:
5166:
5150:
5109:
5091:
5050:
5034:
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4876:
4795:
4785:
4732:
4724:
4673:
4663:
4619:
4611:
4559:
4459:
4418:
4410:
4293:
4252:
4236:
4146:
4126:
3969:
3627:
3557:
3451:
3443:
3339:
3321:
3280:
3262:
3176:
3136:
2974:
2958:
2897:
2764:
Healthgrid applications and core technologies : proceedings of HealthGrid 2010
2733:
2725:
2688:
2666:
2658:
2604:
2563:
2545:
2459:
2425:
2405:
2353:
2345:
2250:
2198:
2113:
2076:
2068:
1819:
1654:
1634:
1287:
1143:(Aleve) should be avoided as they can increase the risk of bleeding complications.
1101:
1026:
905:
852:
796:
730:
591:
556:
519:
335:
283:
143:
69:
5637:
6734:
6364:
6357:
6352:
6155:
6066:
5946:
5941:
5676:
5580:
5474:
4790:
3326:
3267:
2962:
2550:
2463:
2409:
1674:
1358:
1128:
1034:
939:
844:
818:
808:
669:
657:
515:
219:
129:
Fever, headache, muscle and joint pain, rash. Can be severe, mild or asymptomatic
5418:
5395:
5137:
Kariyawasam R, Lachman M, Mansuri S, Chakrabarti S, Boggild AK (20 April 2023).
4564:
4547:
4298:
4281:
754:, and can infect other mammals. An infection can be acquired via a single bite.
6561:
6249:
6220:
5688:
5648:
5096:
3974:
3562:
2255:
1881:
1440:
1398:
1300:
956:
858:
The white blood cells respond by producing several signaling proteins, such as
775:
771:
763:
747:
549:
409:
370:. Blood tests are available to confirm the diagnosis including detecting viral
6616:
5591:
5154:
3180:
2947:"Animals as potential reservoirs for dengue transmission: A systematic review"
2662:
6972:
6908:
6818:
6766:
6687:
6669:
6591:
6511:
6387:
6369:
6281:
6071:
5728:
5469:
5442:
5162:
5105:
5046:
4573:
4307:
4248:
3983:
3724:"Sanofi restricts dengue vaccine but downplays antibody enhancement | CIDRAP"
3335:
3276:
2970:
2559:
1815:
1416:
1273:
720:
595:
527:
404:
330:(previously known as dengue hemorrhagic fever or dengue shock syndrome) with
223:
5543:
5038:
712:
Dengue virus is most frequently transmitted by the bite of mosquitos in the
6922:
6748:
6522:
6337:
6256:
6190:
6179:
6136:
5971:
5964:
5914:
5879:
5822:
5764:
5450:
5232:
5180:
5123:
5064:
4881:
4809:
4746:
4668:
4473:
4432:
4266:
4138:
3571:
3465:
3353:
3294:
3150:
2988:
2911:
2747:
2680:
2616:
2577:
2471:
2417:
2367:
2264:
2212:
2125:
1891:
1833:
1646:
1432:
1420:
1349:
1338:
1296:
1265:
879:
840:
792:
689:
673:
653:
642:
612:
466:
339:
299:
287:
215:
173:
4728:
4633:
4414:
2349:
2090:
1625:
Kularatne SA (September 2015). "BMJ Best
Practice Review – Dengue fever".
1025:; Patients with severe plasma leakage may have fluid accumulation in the
791:
avoid bites such as by wearing clothing that fully covers the skin, using
6753:
6743:
6647:
6628:
6455:
6450:
6346:
6325:
6110:
6044:
6001:
5931:
5853:
5777:
5732:
5621:
5020:
4615:
4464:
4447:
3447:
2861:. Centers for Disease Control and Prevention. 2 June 2010. Archived from
2203:
1460:
1354:
1154:
1124:
1070:
1058:
1018:
931:
871:
863:
828:
587:
538:
523:
4737:
4423:
4240:
2729:
2644:"Dengue virus life cycle: viral and host factors modulating infectivity"
2358:
2072:
964:
700:
438:
6940:
6870:
6840:
6790:
6674:
6556:
6437:
6292:
6170:
6101:
5983:
5832:
5643:
4190:
1278:
1256:
1158:
1078:
1062:
1038:
943:
912:
855:, and reproduces inside the cells while they move throughout the body.
848:
782:(from mother to child) during pregnancy or at birth has been reported.
648:
625:
489:
375:
367:
319:
295:
195:
5078:
Obi JO, Gutiérrez-Barbosa H, Chua JV, Deredge DJ (30 September 2021).
4130:
1638:
1389:, meaning "cramp-like seizure" – the full term of the condition being
6949:
5741:
5632:
5597:
3478:
3141:
3124:
3030:
1436:
1378:
1357:
in 1953; by the 1970s, it had become recognised as a major cause of
1136:
1050:
859:
637:
363:
323:
5503:
5136:
1065:. Dengue, chikungunya and zika share the same mode of transmission (
5725:
3958:"Clinical and differential diagnosis: Dengue, chikungunya and Zika"
3882:
Dengue guidelines, for diagnosis, treatment, prevention and control
1476:
1318:
which referred to a "water poison" associated with flying insects.
1140:
843:, as well as specialized immune cell located in the skin, called a
511:
390:
350:
331:
311:
307:
182:
139:
4320:
3481:"Chapter 5 – dengue fever (DF) and dengue hemorrhagic fever (DHF)"
3033:"Chapter 5 – dengue fever (DF) and dengue hemorrhagic fever (DHF)"
1150:
with analgesics, fluid replacement, and bed rest are recommended.
6879:
6828:
6806:
5602:
1492:
1484:
1330:
1231:
1132:
1084:
1074:
1054:
1030:
1010:
divides dengue fever into two classes: uncomplicated and severe.
927:
896:
758:
751:
685:
583:
359:
315:
291:
211:
5569:
5417:
Shepard DS, Undurraga EA, Halasa YA, Stanaway JD (August 2016).
1800:"Dengue haemorrhagic fever or dengue shock syndrome in children"
1734:"World's first dengue fever vaccine launched in the Philippines"
1325:, spread out of Africa in the 15th to 19th centuries due to the
6917:
6696:
6425:
6414:
5538:
5515:
5488:
5077:
3914:
3398:"Host Response to the Dengue Virus | Learn Science at Scitable"
3217:"Host Response to the Dengue Virus | Learn Science at Scitable"
2712:
Guzman MG, Halstead SB, Artsob H, et al. (December 2010).
1488:
681:
665:
629:
5724:
5416:
5419:"The global economic burden of dengue: a systematic analysis"
5080:"Current Trends and Limitations in Dengue Antiviral Research"
1402:
1334:
1097:
867:
714:
555:
The rash of dengue fever in the acute stage of the infection
399:
395:
303:
178:
48:
5683:
2641:
2591:
Paixão ES, Teixeira MG, Costa MN, Rodrigues LC (July 2016).
2590:
2497:
2495:
2493:
2491:
2489:
5988:
4993:
Vaccines for biodefense and emerging and neglected diseases
4827:"As Temperatures Rise, Dengue Fever Spreads and Cases Rise"
4707:
4393:
2328:
2103:
1763:
1761:
1759:
1757:
1755:
1501:
A National Dengue Day is held in India annually on 16 May.
1498:
The Philippines has an awareness month in June since 1998.
800:
661:
534:
96:
87:
81:
78:
4965:. River Edge, N.J: Imperial College Press. pp. 1–10.
3622:
3620:
3618:
3593:"Controlling Dengue Outbreaks | Learn Science at Scitable"
3065:
National Institute of Allergy and Infectious Diseases, NIH
1487:, Indonesia, in 2011. Further events were held in 2012 in
5306:
The International Society for Neglected Tropical Diseases
2486:
1105:
617:
371:
199:
93:
84:
4708:
Simmons CP, Farrar JJ, Nguyen vV, Wills B (April 2012).
4394:
Simmons CP, Farrar JJ, Nguyen vV, Wills B (April 2012).
4214:
3308:
Teo A, Tan HD, Loy T, Chia PY, Chua CL (30 March 2023).
3249:
Teo A, Tan HD, Loy T, Chia PY, Chua CL (30 March 2023).
2642:
Rodenhuis-Zybert IA, Wilschut J, Smit JM (August 2010).
2329:
Simmons CP, Farrar JJ, Nguyen vV, Wills B (April 2012).
1752:
4522:"Dengue increase likely during rainy season: WHO warns"
3615:
2531:
1956:"Dengue: How to keep children safe | UNICEF South Asia"
5362:"Did you know: Dengue Awareness Month | Inquirer News"
5278:
ACTION AGAINST DENGUE Dengue Day Campaigns Across Asia
3587:
3585:
3429:
1950:
1948:
1880:
Schaefer TJ, Panda PK, Wolford RW (14 November 2022).
1704:
Nelson Textbook of Pediatrics: The field of pediatrics
1108:
antibodies, but this does not determine the serotype.
5660:
3951:
3949:
3947:
1986:"Dengue vaccine: WHO position paper – September 2018"
5493:
3061:
2945:
Gwee SX, St John AL, Gray GC, Pang J (1 June 2021).
2711:
1879:
75:
5336:
Official Gazette of the Republic of the Philippines
4069:
4040:
4038:
4007:
4005:
3816:"International Classification of Diseases (ICD-11)"
3728:
Center for Infectious Disease Research & Policy
3582:
3430:Martina BE, Koraka P, Osterhaus AD (October 2009).
3368:"Antibody-dependent Enhancement (ADE) and Vaccines"
2944:
2830:. World Health Organization. 2012. pp. 16–17.
1945:
1685:
1683:
1519:
Climate change and infectious diseases#Dengue fever
444:
Schematic depiction of the symptoms of dengue fever
72:
4117:Kularatne SA (15 September 2015). "Dengue fever".
3944:
3094:"Dengue Transmission | Learn Science at Scitable"
3068:(1 ed.). Totowa, N.J.: Humana. p. 268.
2824:Global Strategy For Dengue Prevention And Control
750:of the virus, but it also circulates in nonhuman
465:Typically, people infected with dengue virus are
353:; infection with one type usually gives lifelong
6970:
4989:
4962:Dengue (Tropical Medicine: Science and Practice)
4323:"What is characteristic of hyperendemic dengue?"
4035:
4002:
3168:
2767:( ed.). Amsterdam: IOS Press. p. 235.
1845:
1843:
1707:. Elsevier Health Sciences. 2016. p. 1631.
1680:
1188:Dengue fever deaths per million persons in 2012
5338:. Official Gazette. 2 June 2011. Archived from
5023:"Dengue Research Opportunities in the Americas"
4445:
4367:Desk Encyclopedia of Human and Medical Virology
3432:"Dengue virus pathogenesis: an integrated view"
3244:
3242:
2291:Desk Encyclopedia of Human and Medical Virology
2181:
1341:during the 18th century were caused by dengue.
1112:provide the most reliable method of diagnosis.
514:. This may result in fluid accumulation in the
4356:
4354:
4217:"The global distribution and burden of dengue"
3546:"Yellow fever and dengue: a threat to Europe?"
2239:"Yellow fever and dengue: a threat to Europe?"
1405:, and the disease was known as "dandy fever".
728:species that may transmit the disease include
389:Dengue is spread by several species of female
5710:
5246:
5244:
5242:
4162:"Dengue Areas of Risk Around the World | CDC"
3962:Revista Médica del Hospital General de México
3307:
3248:
3164:
3162:
3160:
2449:
2280:
2278:
2054:
1840:
1246:An online map showing reports of dengue fever
578:
4593:
4591:
4589:
4587:
4585:
4583:
4343:: CS1 maint: multiple names: authors list (
3878:
3425:
3423:
3239:
3129:Journal of Infection in Developing Countries
3116:
2883:
2097:
1886:. Bethesda, MD, USA: StatPearls Publishing.
1443:medicine targeting the NS3 or NS5 proteins.
1291:. Both these species have expanding ranges.
770:Dengue can also be transmitted via infected
6161:Severe fever with thrombocytopenia syndrome
4958:
4369:. Boston: Academic Press. pp. 372–82.
4351:
4044:
3874:
3872:
3688:"Dengvaxia : EPAR - Medicine overview"
3508:
3506:
3479:Center for Disease Control and Prevention.
3031:Center for Disease Control and Prevention.
3026:
3024:
3005:. World Health Organization. Archived from
2760:
2707:
2705:
2324:
2322:
2320:
2318:
2316:
2314:
2293:. Boston: Academic Press. pp. 372–82.
1419:, in a 1789 report of the 1780 epidemic in
5717:
5703:
5239:
5192:
5190:
5143:Therapeutic Advances in Infectious Disease
4701:
4191:"Dengue (Causes, Symptoms, and Treatment)"
4166:Centers for Disease Control and Prevention
4112:
4110:
4108:
4084:Centers for Disease Control and Prevention
3851:Centers for Disease Control and Prevention
3519:Centers for Disease Control and Prevention
3172:Emerging Epidemics: Management and Control
3157:
3122:
2445:
2443:
2441:
2439:
2437:
2435:
2395:
2275:
2177:
2175:
2173:
1978:
1927:Centers for Disease Control and Prevention
1855:Centers for Disease Control and Prevention
1797:
1575:
1573:
1571:
1569:
1567:
1565:
1563:
1561:
1559:
938:to these areas. Generalized spraying with
652:. Other members of the same genus include
632:(the cluster of dark dots near the center)
47:
5222:
5199:"Is dengue a threat to the blood supply?"
5170:
5113:
5095:
5054:
4996:. San Diego: Academic. pp. 287–323.
4983:
4920:
4890:
4880:
4859:
4799:
4789:
4736:
4677:
4667:
4646:
4623:
4580:
4563:
4463:
4422:
4387:
4365:. In Mahy BW, Van Regenmortel MH (eds.).
4297:
4256:
4116:
3973:
3885:. World Health Organization. p. 46.
3561:
3472:
3455:
3420:
3343:
3325:
3284:
3266:
3140:
2978:
2901:
2737:
2670:
2567:
2549:
2357:
2289:. In Mahy BW, Van Regenmortel MH (eds.).
2254:
2232:
2230:
2202:
2080:
1823:
1624:
1620:
1618:
1616:
1614:
1612:
1610:
1608:
1606:
1557:
1555:
1553:
1551:
1549:
1547:
1545:
1543:
1541:
1539:
1321:The principal mosquito vector of dengue,
834:
795:while resting, and/or the application of
668:(genetic material) contains about 11,000
5478:) is being considered for deletion. See
5196:
5084:Tropical Medicine and Infectious Disease
4954:
4952:
4950:
4948:
4545:
4439:
4321:Darvin Scott Smith, MD, MSc, DTM&H.
4279:
4013:"Dengue fever - Diagnosis and treatment"
3869:
3503:
3169:Bisen PS, Raghuvanshi R (22 July 2013).
3125:"Unusual mode of transmission of dengue"
3021:
2702:
2311:
1470:
1183:
1083:
1008:International Classification of Diseases
968:Illustration of a subcutaneous injection
963:
895:
817:
699:
616:
322:, and a characteristic skin itching and
5187:
4105:
3537:
3372:The Children's Hospital of Philadelphia
2815:
2793:"Aedes aegypti – Factsheet for experts"
2432:
2391:
2389:
2170:
2048:
1725:
1721:from the original on 10 September 2017.
680:molecules (C, prM and E) that form the
524:depletion of fluid from the circulation
6971:
4640:
4597:
4360:
3826:from the original on 20 September 2023
3543:
2635:
2398:Current Opinion in Infectious Diseases
2284:
2236:
2227:
2055:Henchal EA, Putnak JR (October 1990).
1731:
1603:
1536:
1449:
1157:, decreasing platelets and increasing
847:. The Langerhans cells migrate to the
528:decreased blood supply to vital organs
6532:Hemorrhagic fever with renal syndrome
5698:
4945:
4910:from the original on 3 December 2013.
4853:
4697:from the original on 3 December 2013.
4600:"Dengue and dengue hemorrhagic fever"
4189:Lowth M, et al. (22 June 2022).
4188:
4184:
4182:
3857:from the original on 29 February 2024
3638:from the original on 25 February 2024
3491:from the original on 29 December 2010
3408:from the original on 23 February 2024
3378:from the original on 29 February 2024
3227:from the original on 23 February 2024
3197:from the original on 23 February 2024
3104:from the original on 28 February 2024
3043:from the original on 29 December 2010
2884:Gould EA, Solomon T (February 2008).
2877:
2847:from the original on 30 October 2012.
2513:from the original on 26 February 2024
2036:from the original on 27 February 2024
1966:from the original on 13 February 2024
1933:from the original on 14 February 2024
1917:
1915:
1913:
1898:from the original on 14 December 2021
1861:from the original on 14 February 2024
1779:from the original on 13 February 2024
1285:and other related mosquitoes such as
428:
4771:
3847:"Dengue Clinical Presentation | CDC"
2714:"Dengue: a continuing global threat"
2698:from the original on 9 October 2022.
2651:Cellular and Molecular Life Sciences
2503:"Dengue fever - Symptoms and causes"
2386:
2158:from the original on 26 January 2024
2026:"Qdenga | European Medicines Agency"
1740:from the original on 18 October 2016
1257:https://www.healthmap.org/dengue/en/
6035:Venezuelan equine encephalomyelitis
5372:from the original on 7 January 2019
5312:from the original on 7 January 2019
5280:. World Health Organization. 2011.
5139:"A dengue vaccine whirlwind update"
4753:from the original on 28 August 2021
4717:The New England Journal of Medicine
4403:The New England Journal of Medicine
4159:
4047:"Dengue Treatment & Management"
3844:
3512:
2926:from the original on 28 August 2021
2859:"Travelers' Health Outbreak Notice"
2623:from the original on 28 August 2021
2374:from the original on 28 August 2021
2338:The New England Journal of Medicine
2006:from the original on 5 January 2019
1466:
1431:Research directions include dengue
13:
5197:Teo D, Ng LC, Lam S (April 2009).
4765:
4179:
4093:from the original on 10 March 2024
4057:from the original on 10 March 2024
4045:Scott Smith D (16 November 2022).
4023:from the original on 10 March 2024
3899:from the original on 16 March 2024
3796:from the original on 16 March 2024
3754:"Administering the Dengue Vaccine"
1910:
1591:from the original on 14 March 2024
1504:
922:The primary method of controlling
480:
14:
7010:
5482:to help reach a consensus. ›
5461:
5010:from the original on 12 May 2016.
4990:Barrett AD, Stanberry LR (2009).
4979:from the original on 21 May 2016.
4383:from the original on 9 June 2016.
3990:from the original on 4 March 2024
3932:from the original on 4 March 2024
3879:Organization WH (21 April 2009).
3764:from the original on 8 March 2024
3734:from the original on 9 March 2024
3704:from the original on 9 March 2024
3668:from the original on 8 March 2024
3603:from the original on 8 March 2024
3578:from the original on 7 July 2011.
3525:from the original on 8 March 2024
2803:from the original on 10 July 2017
2307:from the original on 9 June 2016.
2271:from the original on 7 July 2011.
1677:in the Merriam-Webster Dictionary
1454:
1035:insufficient protein in the blood
997:
891:
851:, where the infection spreads to
56:Typical rash seen in dengue fever
6025:Western equine encephalomyelitis
6015:Eastern equine encephalomyelitis
5682:
5670:
5332:"Dengue Awareness Month | GOVPH"
5302:"Calling for a World Dengue Day"
5215:10.1111/j.1365-3148.2009.00916.x
4933:from the original on 5 June 2011
4778:PLOS Neglected Tropical Diseases
3082:from the original on 1 May 2016.
2781:from the original on 1 May 2016.
2538:PLOS Neglected Tropical Diseases
2452:Pediatric Critical Care Medicine
1999:(93): 457–76. 7 September 2018.
1251:
1110:Nucleic acid amplification tests
564:
548:
451:
437:
349:Dengue virus has four confirmed
68:
6150:Crimean–Congo hemorrhagic fever
5410:
5384:
5354:
5324:
5294:
5270:
5130:
5071:
5014:
4914:
4844:
4819:
4539:
4514:
4488:
4314:
4273:
4208:
4153:
3926:MSD Manual Professional Edition
3838:
3808:
3776:
3746:
3716:
3680:
3650:
3390:
3360:
3301:
3209:
3086:
3055:
3003:"Vector-borne viral infections"
2995:
2938:
2851:
2785:
2754:
2597:The Lancet. Infectious Diseases
2584:
2525:
2140:
2018:
1873:
1851:"Dengue | CDC Yellow Book 2024"
1798:Alejandria MM (10 April 2015).
1173:
1139:(Advil, Motrin IB, others) and
785:
695:
458:Clinical course of dengue fever
6312:Kemerovo tickborne viral fever
5423:The Lancet Infectious Diseases
5027:Journal of Infectious Diseases
4546:Jing Q, Wang M (1 June 2019).
4446:Whitehorn J, Farrar J (2010).
3922:"Dengue - Infectious Diseases"
3123:Wiwanitkit V (November 2009).
2182:Whitehorn J, Farrar J (2010).
1791:
1695:
1661:
1344:It is assumed that dengue was
977:antibody-dependent enhancement
883:complication of dengue fever.
813:antibody-dependent enhancement
344:dangerously low blood pressure
236:, decreasing mosquito exposure
148:dangerously low blood pressure
1:
6569:Hantavirus pulmonary syndrome
5808:Jamestown Canyon encephalitis
5467:
5435:10.1016/s1473-3099(16)00146-8
5394:. 6 June 2018. Archived from
4604:Clinical Microbiology Reviews
3436:Clinical Microbiology Reviews
3062:St. Georgiev, Vassil (2009).
2903:10.1016/S0140-6736(08)60238-X
2609:10.1016/S1473-3099(16)00088-8
2148:"Neglected tropical diseases"
2118:10.1016/S0140-6736(23)02576-X
2061:Clinical Microbiology Reviews
1993:Weekly Epidemiological Record
1529:
1414:United States Founding Father
1412:was applied by physician and
886:
336:low levels of blood platelets
144:low levels of blood platelets
21:Dengue fever (disambiguation)
6994:Vaccine-preventable diseases
6463:Venezuelan hemorrhagic fever
4791:10.1371/journal.pntd.0004101
4280:Jing Q, Wang M (June 2019).
3327:10.1371/journal.ppat.1011223
3268:10.1371/journal.ppat.1011223
2963:10.1016/j.onehlt.2021.100216
2718:Nature Reviews. Microbiology
2551:10.1371/journal.pntd.0010724
2464:10.1097/PCC.0b013e3181e911a7
2410:10.1097/QCO.0b013e32833c1d16
1372:
1301:an increasingly warm climate
1230:As of March 2023, dengue is
1164:
1115:
1100:) can be used to detect the
1044:
7:
6485:Brazilian hemorrhagic fever
6473:Argentine hemorrhagic fever
4923:"Definition of Dandy fever"
4565:10.1016/j.glohj.2019.06.002
4299:10.1016/j.glohj.2019.06.002
4119:BMJ (Clinical Research Ed.)
3658:"Information on Dengvaxia®"
1512:
1426:
803:being the most effective).
606:
488:The febrile phase involves
10:
7015:
6497:Bolivian hemorrhagic fever
6377:Sandfly fever Naples virus
5252:"Marking ASEAN Dengue Day"
5097:10.3390/tropicalmed6040180
4921:Anonymous (15 June 1998).
3975:10.1016/j.hgmx.2016.09.011
3563:10.2807/ese.15.10.19509-en
2256:10.2807/ese.15.10.19509-en
1769:"Dengue- Global situation"
1581:"Dengue and severe dengue"
1491:, Myanmar, and in 2013 in
1309:
1177:
954:
950:
903:
636:Dengue virus (DENV) is an
610:
579:Complications and sequelae
423:neglected tropical disease
18:
6938:
6906:
6897:
6868:
6838:
6816:
6805:
6764:
6732:
6685:
6626:
6615:
6589:
6520:
6435:
6424:
6413:
6385:
6335:
6324:
6290:
6270:
6188:
6165:Huaiyangshan banyangvirus
6134:
6123:
6099:
5999:
5877:
5762:
5751:
5740:
5612:
5497:
5155:10.1177/20499361231167274
4526:World Health Organization
4160:CDC (21 September 2023).
3820:World Health Organization
3789:World Health Organization
3695:European Medicines Agency
3515:"Traveling? Avoid Dengue"
3181:10.1002/9781118393277.ch8
2886:"Pathogenic flaviviruses"
2663:10.1007/s00018-010-0357-z
2152:World Health Organization
2030:European Medicines Agency
1773:World Health Organization
1585:World Health Organization
1299:, population growth, and
1250:
1245:
1240:
1004:World Health Organization
936:biological control agents
746:. Humans are the primary
266:
262:5 million per year (2023)
258:
240:
229:
205:
188:
169:
161:
153:
133:
123:
111:
60:
55:
46:
38:
33:
6781:SARS-related coronavirus
6744:Henipavirus encephalitis
6602:Murid gammaherpesvirus 4
6447:Viral hemorrhagic fevers
6228:Viral hemorrhagic fevers
6200:Arbovirus encephalitides
6176:Arbovirus encephalitides
6146:Viral hemorrhagic fevers
6111:Banna virus encephalitis
6011:Arbovirus encephalitides
5956:Viral hemorrhagic fevers
5922:Saint Louis encephalitis
5889:Arbovirus encephalitides
5840:Viral hemorrhagic fevers
5774:Arbovirus encephalitides
5480:templates for discussion
4772:Kuno G (November 2015).
4452:British Medical Bulletin
4077:"Dengue Case Management"
3909:Textbox B and Textbox C.
3628:"Factsheet about dengue"
2191:British Medical Bulletin
1923:"Dengue Diagnosis | CDC"
601:
501:dengue hemorrhagic fever
298:areas. It is frequently
157:3–14 days after exposure
6885:Yaba monkey tumor virus
6242:Kyasanur Forest disease
6204:Tick-borne encephalitis
5905:Australian encephalitis
5798:California encephalitis
4598:Gubler DJ (July 1998).
3544:Reiter P (March 2010).
3513:CDC (20 October 2023).
3402:© 2014 Nature Education
3098:© 2014 Nature Education
2237:Reiter P (March 2010).
1732:East S (6 April 2016).
1071:infected simultaneously
1039:thickening of the blood
708:feeding on a human host
42:Dengue, breakbone fever
6232:Omsk hemorrhagic fever
5813:La Crosse encephalitis
4882:10.3201/eid1206.ET1206
4669:10.3201/eid1206.ET1206
2761:Solomonides T (2010).
1692:in Oxford Dictionaries
1524:Dengue fever outbreaks
1480:
1227:
1180:Dengue fever outbreaks
1089:
969:
926:is by eliminating its
901:
876:capillary permeability
835:Mechanism of infection
823:
709:
633:
207:Differential diagnosis
16:Mosquito-borne disease
6984:Insect-borne diseases
6665:Marburg virus disease
6216:Powassan encephalitis
5893:Japanese encephalitis
5392:"National Dengue Day"
5366:newsinfo.inquirer.net
5149:: 20499361231167274.
5039:10.1093/infdis/jis351
4729:10.1056/NEJMra1110265
4552:Global Health Journal
4548:"Dengue epidemiology"
4415:10.1056/NEJMra1110265
4286:Global Health Journal
4282:"Dengue epidemiology"
3845:CDC (13 April 2023).
3175:(1 ed.). Wiley.
2350:10.1056/NEJMra1110265
1804:BMJ Clinical Evidence
1474:
1316:Jin dynasty (266–420)
1187:
1087:
967:
899:
821:
780:Vertical transmission
737:A. polynesiensis
703:
628:showing dengue virus
620:
505:dengue shock syndrome
270:5,000 per year (2023)
6091:Semliki Forest virus
4959:Halstead SB (2008).
4862:"Etymologia: dengue"
4649:"Etymologia: dengue"
4616:10.1128/cmr.11.3.480
4500:Yale Environment 360
3448:10.1128/CMR.00035-09
2057:"The dengue viruses"
2032:. 16 December 2022.
1673:17 July 2022 at the
718:genus, particularly
234:Dengue fever vaccine
198:to the virus or its
19:For other uses, see
6638:Ebola virus disease
6302:Colorado tick fever
6057:O'nyong'nyong fever
4241:10.1038/nature12060
4233:2013Natur.496..504B
3730:. 1 December 2017.
3374:. 7 December 2020.
2730:10.1038/nrmicro2460
2724:(12 Suppl): S7–16.
2073:10.1128/CMR.3.4.376
1450:Society and culture
1361:in Southeast Asia.
743:A. scutellaris
413:four years of age.
6850:Simian foamy virus
5613:External resources
4869:Emerg. Infect. Dis
4860:Anonymous (2006).
4656:Emerg. Infect. Dis
4647:Anonymous (2006).
4465:10.1093/bmb/ldq019
4361:Gubler DJ (2010).
4019:. 5 October 2022.
3822:. 1 January 2022.
3632:www.ecdc.europa.eu
3009:on 3 February 2011
2797:www.ecdc.europa.eu
2285:Gubler DJ (2010).
2204:10.1093/bmb/ldq019
2112:(10427): 667–682.
1481:
1346:constantly present
1228:
1090:
1019:low blood pressure
970:
902:
824:
731:A. albopictus
710:
678:structural protein
654:yellow fever virus
634:
429:Signs and symptoms
253:blood transfusions
249:intravenous fluids
118:Infectious disease
6989:Tropical diseases
6966:
6965:
6962:
6961:
6958:
6957:
6893:
6892:
6801:
6800:
6611:
6610:
6409:
6408:
6405:
6404:
6320:
6319:
6119:
6118:
5864:Rift Valley fever
5658:
5657:
5398:on 7 January 2019
5342:on 7 January 2019
5287:978-92-9061-539-2
5003:978-0-12-369408-9
4972:978-1-84816-228-0
4376:978-0-12-375147-8
4227:(7446): 504–507.
4131:10.1136/bmj.h4661
3892:978-92-4-154787-1
3760:. 26 April 2023.
3634:. 7 August 2023.
3550:Euro Surveillance
3190:978-1-118-39323-9
3075:978-1-60327-297-1
2865:on 26 August 2010
2837:978-92-4-150403-4
2774:978-1-60750-582-2
2300:978-0-12-375147-8
2243:Euro Surveillance
1714:978-1-4557-7566-8
1639:10.1136/bmj.h4661
1587:. 17 March 2023.
1262:
1261:
1023:hypovolemic shock
853:white blood cells
499:(formerly called
471:incubation period
274:
273:
190:Diagnostic method
28:Medical condition
7006:
6904:
6903:
6814:
6813:
6624:
6623:
6433:
6432:
6422:
6421:
6397:Chandipura virus
6333:
6332:
6273:Orthomyxoviridae
6132:
6131:
6079:Ross River fever
5844:Bunyamwera fever
5760:
5759:
5749:
5748:
5719:
5712:
5705:
5696:
5695:
5687:
5686:
5675:
5674:
5673:
5666:
5495:
5494:
5455:
5454:
5414:
5408:
5407:
5405:
5403:
5388:
5382:
5381:
5379:
5377:
5358:
5352:
5351:
5349:
5347:
5328:
5322:
5321:
5319:
5317:
5298:
5292:
5291:
5274:
5268:
5267:
5265:
5263:
5254:. Archived from
5248:
5237:
5236:
5226:
5194:
5185:
5184:
5174:
5134:
5128:
5127:
5117:
5099:
5075:
5069:
5068:
5058:
5033:(7): 1121–1127.
5018:
5012:
5011:
4987:
4981:
4980:
4956:
4943:
4942:
4940:
4938:
4918:
4912:
4911:
4909:
4894:
4884:
4866:
4857:
4851:
4848:
4842:
4841:
4839:
4837:
4823:
4817:
4816:
4803:
4793:
4784:(11): e0004101.
4769:
4763:
4762:
4760:
4758:
4740:
4714:
4705:
4699:
4698:
4696:
4681:
4671:
4653:
4644:
4638:
4637:
4627:
4595:
4578:
4577:
4567:
4543:
4537:
4536:
4534:
4532:
4518:
4512:
4511:
4509:
4507:
4492:
4486:
4485:
4467:
4443:
4437:
4436:
4426:
4400:
4391:
4385:
4384:
4363:"Dengue viruses"
4358:
4349:
4348:
4342:
4334:
4332:
4330:
4318:
4312:
4311:
4301:
4277:
4271:
4270:
4260:
4212:
4206:
4205:
4203:
4201:
4186:
4177:
4176:
4174:
4172:
4157:
4151:
4150:
4114:
4103:
4102:
4100:
4098:
4092:
4081:
4073:
4067:
4066:
4064:
4062:
4042:
4033:
4032:
4030:
4028:
4009:
4000:
3999:
3997:
3995:
3977:
3953:
3942:
3941:
3939:
3937:
3918:
3912:
3911:
3906:
3904:
3876:
3867:
3866:
3864:
3862:
3842:
3836:
3835:
3833:
3831:
3812:
3806:
3805:
3803:
3801:
3780:
3774:
3773:
3771:
3769:
3750:
3744:
3743:
3741:
3739:
3720:
3714:
3713:
3711:
3709:
3703:
3692:
3684:
3678:
3677:
3675:
3673:
3654:
3648:
3647:
3645:
3643:
3624:
3613:
3612:
3610:
3608:
3589:
3580:
3579:
3565:
3541:
3535:
3534:
3532:
3530:
3510:
3501:
3500:
3498:
3496:
3485:2010 Yellow Book
3476:
3470:
3469:
3459:
3427:
3418:
3417:
3415:
3413:
3394:
3388:
3387:
3385:
3383:
3364:
3358:
3357:
3347:
3329:
3305:
3299:
3298:
3288:
3270:
3246:
3237:
3236:
3234:
3232:
3213:
3207:
3206:
3204:
3202:
3166:
3155:
3154:
3144:
3142:10.3855/jidc.145
3120:
3114:
3113:
3111:
3109:
3090:
3084:
3083:
3059:
3053:
3052:
3050:
3048:
3037:2010 Yellow Book
3028:
3019:
3018:
3016:
3014:
2999:
2993:
2992:
2982:
2942:
2936:
2935:
2933:
2931:
2905:
2881:
2875:
2874:
2872:
2870:
2855:
2849:
2848:
2846:
2829:
2819:
2813:
2812:
2810:
2808:
2789:
2783:
2782:
2758:
2752:
2751:
2741:
2709:
2700:
2699:
2697:
2674:
2648:
2639:
2633:
2632:
2630:
2628:
2588:
2582:
2581:
2571:
2553:
2529:
2523:
2522:
2520:
2518:
2499:
2484:
2483:
2447:
2430:
2429:
2393:
2384:
2383:
2381:
2379:
2361:
2335:
2326:
2309:
2308:
2287:"Dengue viruses"
2282:
2273:
2272:
2258:
2234:
2225:
2224:
2206:
2188:
2179:
2168:
2167:
2165:
2163:
2144:
2138:
2137:
2101:
2095:
2094:
2084:
2052:
2046:
2045:
2043:
2041:
2022:
2016:
2015:
2013:
2011:
2005:
1990:
1982:
1976:
1975:
1973:
1971:
1952:
1943:
1942:
1940:
1938:
1929:. 13 June 2019.
1919:
1908:
1907:
1905:
1903:
1877:
1871:
1870:
1868:
1866:
1847:
1838:
1837:
1827:
1795:
1789:
1788:
1786:
1784:
1765:
1750:
1749:
1747:
1745:
1729:
1723:
1722:
1699:
1693:
1687:
1678:
1665:
1659:
1658:
1622:
1601:
1600:
1598:
1596:
1577:
1467:Public awareness
1410:break-bone fever
1350:Second World War
1288:Aedes albopictus
1255:
1254:
1238:
1237:
1223:
1217:
1211:
1205:
1199:
1193:
906:Mosquito control
845:Langerhans cells
797:insect repellent
793:mosquito netting
670:nucleotide bases
592:low birth weight
568:
552:
520:abdominal cavity
455:
441:
103:
102:
99:
98:
95:
90:
89:
86:
83:
80:
77:
74:
51:
31:
30:
7014:
7013:
7009:
7008:
7007:
7005:
7004:
7003:
6969:
6968:
6967:
6954:
6934:
6899:
6889:
6864:
6834:
6808:
6797:
6760:
6735:Paramyxoviridae
6728:
6681:
6618:
6607:
6585:
6516:
6427:
6416:
6401:
6381:
6365:Pappataci fever
6358:Oropouche virus
6353:Oropouche fever
6327:
6316:
6286:
6266:
6184:
6156:Heartland virus
6126:
6115:
6095:
6067:Pogosta disease
5995:
5942:West Nile fever
5873:
5754:
5743:
5736:
5723:
5693:
5681:
5671:
5669:
5661:
5659:
5654:
5653:
5608:
5607:
5506:
5483:
5464:
5459:
5458:
5415:
5411:
5401:
5399:
5390:
5389:
5385:
5375:
5373:
5368:. 9 June 2015.
5360:
5359:
5355:
5345:
5343:
5330:
5329:
5325:
5315:
5313:
5300:
5299:
5295:
5288:
5276:
5275:
5271:
5261:
5259:
5258:on 17 June 2015
5250:
5249:
5240:
5195:
5188:
5135:
5131:
5076:
5072:
5019:
5015:
5004:
4988:
4984:
4973:
4957:
4946:
4936:
4934:
4927:MedicineNet.com
4919:
4915:
4907:
4864:
4858:
4854:
4849:
4845:
4835:
4833:
4825:
4824:
4820:
4770:
4766:
4756:
4754:
4723:(15): 1423–32.
4712:
4706:
4702:
4694:
4651:
4645:
4641:
4596:
4581:
4544:
4540:
4530:
4528:
4520:
4519:
4515:
4505:
4503:
4494:
4493:
4489:
4444:
4440:
4409:(15): 1423–32.
4398:
4392:
4388:
4377:
4359:
4352:
4336:
4335:
4328:
4326:
4319:
4315:
4278:
4274:
4213:
4209:
4199:
4197:
4187:
4180:
4170:
4168:
4158:
4154:
4115:
4106:
4096:
4094:
4090:
4079:
4075:
4074:
4070:
4060:
4058:
4043:
4036:
4026:
4024:
4011:
4010:
4003:
3993:
3991:
3954:
3945:
3935:
3933:
3920:
3919:
3915:
3902:
3900:
3893:
3877:
3870:
3860:
3858:
3843:
3839:
3829:
3827:
3814:
3813:
3809:
3799:
3797:
3782:
3781:
3777:
3767:
3765:
3752:
3751:
3747:
3737:
3735:
3722:
3721:
3717:
3707:
3705:
3701:
3690:
3686:
3685:
3681:
3671:
3669:
3656:
3655:
3651:
3641:
3639:
3626:
3625:
3616:
3606:
3604:
3591:
3590:
3583:
3542:
3538:
3528:
3526:
3511:
3504:
3494:
3492:
3477:
3473:
3428:
3421:
3411:
3409:
3396:
3395:
3391:
3381:
3379:
3366:
3365:
3361:
3320:(3): e1011223.
3306:
3302:
3261:(3): e1011223.
3247:
3240:
3230:
3228:
3215:
3214:
3210:
3200:
3198:
3191:
3167:
3158:
3121:
3117:
3107:
3105:
3092:
3091:
3087:
3076:
3060:
3056:
3046:
3044:
3029:
3022:
3012:
3010:
3001:
3000:
2996:
2943:
2939:
2929:
2927:
2896:(9611): 500–9.
2882:
2878:
2868:
2866:
2857:
2856:
2852:
2844:
2838:
2827:
2821:
2820:
2816:
2806:
2804:
2799:. 9 June 2017.
2791:
2790:
2786:
2775:
2759:
2755:
2710:
2703:
2695:
2657:(16): 2773–86.
2646:
2640:
2636:
2626:
2624:
2589:
2585:
2544:(8): e0010724.
2530:
2526:
2516:
2514:
2501:
2500:
2487:
2448:
2433:
2394:
2387:
2377:
2375:
2344:(15): 1423–32.
2333:
2327:
2312:
2301:
2283:
2276:
2235:
2228:
2186:
2180:
2171:
2161:
2159:
2146:
2145:
2141:
2102:
2098:
2053:
2049:
2039:
2037:
2024:
2023:
2019:
2009:
2007:
2003:
1988:
1984:
1983:
1979:
1969:
1967:
1954:
1953:
1946:
1936:
1934:
1921:
1920:
1911:
1901:
1899:
1878:
1874:
1864:
1862:
1849:
1848:
1841:
1796:
1792:
1782:
1780:
1767:
1766:
1753:
1743:
1741:
1730:
1726:
1715:
1701:
1700:
1696:
1688:
1681:
1675:Wayback Machine
1666:
1662:
1623:
1604:
1594:
1592:
1579:
1578:
1537:
1532:
1515:
1507:
1505:Economic burden
1469:
1457:
1452:
1429:
1375:
1359:child mortality
1312:
1252:
1226:
1225:
1221:
1219:
1215:
1213:
1209:
1207:
1203:
1201:
1197:
1195:
1191:
1182:
1176:
1167:
1148:Supportive care
1141:naproxen sodium
1118:
1047:
1000:
959:
953:
940:organophosphate
908:
894:
889:
878:. As a result,
837:
809:body mass index
788:
764:salivary glands
721:A. aegypti
698:
664:. Dengue virus
658:West Nile virus
615:
609:
604:
596:premature birth
581:
576:
575:
574:
573:
572:
569:
561:
560:
553:
539:slow heart rate
483:
481:Clinical course
463:
462:
461:
460:
459:
456:
447:
446:
445:
442:
431:
290:, prevalent in
245:Supportive care
220:viral hepatitis
107:
92:
71:
67:
29:
24:
17:
12:
11:
5:
7012:
7002:
7001:
6996:
6991:
6986:
6981:
6964:
6963:
6960:
6959:
6956:
6955:
6953:
6952:
6946:
6944:
6936:
6935:
6933:
6932:
6927:
6926:
6925:
6914:
6912:
6901:
6895:
6894:
6891:
6890:
6888:
6887:
6882:
6876:
6874:
6866:
6865:
6863:
6862:
6857:
6852:
6846:
6844:
6836:
6835:
6833:
6832:
6824:
6822:
6811:
6803:
6802:
6799:
6798:
6796:
6795:
6794:
6793:
6788:
6778:
6772:
6770:
6762:
6761:
6759:
6758:
6757:
6756:
6751:
6740:
6738:
6730:
6729:
6727:
6726:
6721:
6720:
6719:
6714:
6709:
6704:
6693:
6691:
6683:
6682:
6680:
6679:
6678:
6677:
6672:
6662:
6661:
6660:
6655:
6650:
6645:
6634:
6632:
6621:
6613:
6612:
6609:
6608:
6606:
6605:
6597:
6595:
6587:
6586:
6584:
6583:
6582:
6581:
6576:
6566:
6565:
6564:
6559:
6554:
6549:
6544:
6539:
6528:
6526:
6518:
6517:
6515:
6514:
6509:
6504:
6503:
6502:
6494:
6493:
6492:
6482:
6481:
6480:
6470:
6469:
6468:
6460:
6459:
6458:
6443:
6441:
6430:
6419:
6411:
6410:
6407:
6406:
6403:
6402:
6400:
6399:
6393:
6391:
6383:
6382:
6380:
6379:
6374:
6373:
6372:
6362:
6361:
6360:
6350:
6343:
6341:
6330:
6322:
6321:
6318:
6317:
6315:
6314:
6309:
6308:
6307:
6298:
6296:
6288:
6287:
6285:
6284:
6278:
6276:
6268:
6267:
6265:
6264:
6263:
6262:
6254:
6253:
6252:
6247:
6239:
6238:
6237:
6225:
6224:
6223:
6213:
6212:
6211:
6196:
6194:
6186:
6185:
6183:
6182:
6173:
6168:
6158:
6153:
6142:
6140:
6129:
6121:
6120:
6117:
6116:
6114:
6113:
6107:
6105:
6097:
6096:
6094:
6093:
6088:
6087:
6086:
6076:
6075:
6074:
6064:
6063:
6062:
6054:
6053:
6052:
6042:
6041:
6040:
6032:
6031:
6030:
6022:
6021:
6020:
6007:
6005:
5997:
5996:
5994:
5993:
5992:
5991:
5981:
5980:
5979:
5969:
5968:
5967:
5952:
5951:
5950:
5949:
5939:
5938:
5937:
5929:
5928:
5927:
5919:
5918:
5917:
5912:
5902:
5901:
5900:
5885:
5883:
5875:
5874:
5872:
5871:
5870:
5869:
5861:
5860:
5859:
5851:
5850:
5849:
5836:
5835:
5830:
5829:
5828:
5820:
5819:
5818:
5810:
5805:
5804:
5803:
5795:
5794:
5793:
5785:
5784:
5783:
5770:
5768:
5757:
5746:
5738:
5737:
5729:viral diseases
5722:
5721:
5714:
5707:
5699:
5692:
5691:
5679:
5656:
5655:
5652:
5651:
5640:
5629:
5617:
5616:
5614:
5610:
5609:
5606:
5605:
5594:
5583:
5572:
5561:
5546:
5531:
5507:
5502:
5501:
5499:
5498:Classification
5492:
5491:
5463:
5462:External links
5460:
5457:
5456:
5429:(8): 935–941.
5409:
5383:
5353:
5323:
5293:
5286:
5269:
5238:
5186:
5129:
5070:
5013:
5002:
4982:
4971:
4944:
4913:
4852:
4843:
4818:
4764:
4700:
4639:
4579:
4538:
4513:
4502:. 5 March 2019
4487:
4438:
4386:
4375:
4350:
4313:
4272:
4207:
4178:
4152:
4104:
4068:
4034:
4001:
3968:(3): 146–153.
3943:
3913:
3891:
3868:
3837:
3807:
3775:
3745:
3715:
3679:
3662:www.sanofi.com
3649:
3614:
3597:www.nature.com
3581:
3536:
3502:
3471:
3419:
3389:
3359:
3314:PLOS Pathogens
3300:
3255:PLOS Pathogens
3238:
3221:www.nature.com
3208:
3189:
3156:
3115:
3085:
3074:
3054:
3020:
2994:
2937:
2876:
2850:
2836:
2814:
2784:
2773:
2753:
2701:
2634:
2583:
2524:
2485:
2431:
2385:
2310:
2299:
2274:
2226:
2169:
2139:
2096:
2047:
2017:
1977:
1960:www.unicef.org
1944:
1909:
1872:
1857:. 1 May 2023.
1839:
1790:
1751:
1724:
1713:
1694:
1679:
1660:
1602:
1534:
1533:
1531:
1528:
1527:
1526:
1521:
1514:
1511:
1506:
1503:
1468:
1465:
1456:
1455:Blood donation
1453:
1451:
1448:
1428:
1425:
1399:folk etymology
1374:
1371:
1311:
1308:
1260:
1259:
1248:
1247:
1243:
1242:
1241:External image
1220:
1214:
1208:
1202:
1196:
1190:
1189:
1175:
1172:
1166:
1163:
1127:(Paracetamol,
1117:
1114:
1046:
1043:
999:
998:Severe disease
996:
987:SAGE committee
957:Dengue vaccine
955:Main article:
952:
949:
904:Main article:
893:
892:Vector control
890:
888:
885:
836:
833:
787:
784:
776:organ donation
772:blood products
697:
694:
682:virus particle
676:for the three
640:of the family
611:Main article:
608:
605:
603:
600:
580:
577:
570:
563:
562:
554:
547:
546:
545:
544:
543:
482:
479:
457:
450:
449:
448:
443:
436:
435:
434:
433:
432:
430:
427:
410:dengue vaccine
402:, principally
378:to the virus.
281:mosquito-borne
272:
271:
268:
264:
263:
260:
256:
255:
242:
238:
237:
231:
227:
226:
209:
203:
202:
192:
186:
185:
171:
167:
166:
163:
159:
158:
155:
151:
150:
137:
131:
130:
127:
121:
120:
115:
109:
108:
106:
105:
64:
62:
58:
57:
53:
52:
44:
43:
40:
36:
35:
27:
15:
9:
6:
4:
3:
2:
7011:
7000:
6997:
6995:
6992:
6990:
6987:
6985:
6982:
6980:
6977:
6976:
6974:
6951:
6948:
6947:
6945:
6943:
6942:
6937:
6931:
6928:
6924:
6921:
6920:
6919:
6916:
6915:
6913:
6911:
6910:
6909:Rhabdoviridae
6905:
6902:
6896:
6886:
6883:
6881:
6878:
6877:
6875:
6873:
6872:
6867:
6861:
6858:
6856:
6853:
6851:
6848:
6847:
6845:
6843:
6842:
6837:
6831:
6830:
6826:
6825:
6823:
6821:
6820:
6819:Herpesviridae
6815:
6812:
6810:
6804:
6792:
6789:
6787:
6784:
6783:
6782:
6779:
6777:
6774:
6773:
6771:
6769:
6768:
6767:Coronaviridae
6763:
6755:
6752:
6750:
6747:
6746:
6745:
6742:
6741:
6739:
6737:
6736:
6731:
6725:
6722:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6699:
6698:
6695:
6694:
6692:
6690:
6689:
6688:Rhabdoviridae
6684:
6676:
6673:
6671:
6668:
6667:
6666:
6663:
6659:
6656:
6654:
6651:
6649:
6646:
6644:
6641:
6640:
6639:
6636:
6635:
6633:
6631:
6630:
6625:
6622:
6620:
6614:
6604:
6603:
6599:
6598:
6596:
6594:
6593:
6592:Herpesviridae
6588:
6580:
6577:
6575:
6572:
6571:
6570:
6567:
6563:
6560:
6558:
6555:
6553:
6550:
6548:
6545:
6543:
6540:
6538:
6535:
6534:
6533:
6530:
6529:
6527:
6525:
6524:
6519:
6513:
6510:
6508:
6505:
6500:
6499:
6498:
6495:
6491:
6488:
6487:
6486:
6483:
6479:
6476:
6475:
6474:
6471:
6466:
6465:
6464:
6461:
6457:
6454:
6453:
6452:
6448:
6445:
6444:
6442:
6440:
6439:
6434:
6431:
6429:
6423:
6420:
6418:
6412:
6398:
6395:
6394:
6392:
6390:
6389:
6388:Rhabdoviridae
6384:
6378:
6375:
6371:
6370:Toscana virus
6368:
6367:
6366:
6363:
6359:
6356:
6355:
6354:
6351:
6348:
6345:
6344:
6342:
6340:
6339:
6334:
6331:
6329:
6323:
6313:
6310:
6305:
6304:
6303:
6300:
6299:
6297:
6295:
6294:
6289:
6283:
6282:Bourbon virus
6280:
6279:
6277:
6275:
6274:
6269:
6260:
6259:
6258:
6255:
6251:
6248:
6245:
6244:
6243:
6240:
6235:
6234:
6233:
6229:
6226:
6222:
6219:
6218:
6217:
6214:
6210:
6207:
6206:
6205:
6201:
6198:
6197:
6195:
6193:
6192:
6187:
6181:
6177:
6174:
6172:
6169:
6166:
6162:
6159:
6157:
6154:
6151:
6147:
6144:
6143:
6141:
6139:
6138:
6133:
6130:
6128:
6122:
6112:
6109:
6108:
6106:
6104:
6103:
6098:
6092:
6089:
6085:
6082:
6081:
6080:
6077:
6073:
6072:Sindbis virus
6070:
6069:
6068:
6065:
6060:
6059:
6058:
6055:
6051:
6048:
6047:
6046:
6043:
6038:
6037:
6036:
6033:
6028:
6027:
6026:
6023:
6018:
6017:
6016:
6012:
6009:
6008:
6006:
6004:
6003:
5998:
5990:
5987:
5986:
5985:
5982:
5978:
5975:
5974:
5973:
5970:
5966:
5963:
5962:
5961:
5957:
5954:
5953:
5948:
5945:
5944:
5943:
5940:
5935:
5934:
5933:
5930:
5925:
5924:
5923:
5920:
5916:
5913:
5911:
5908:
5907:
5906:
5903:
5899:
5896:
5895:
5894:
5890:
5887:
5886:
5884:
5882:
5881:
5876:
5867:
5866:
5865:
5862:
5857:
5856:
5855:
5852:
5847:
5846:
5845:
5841:
5838:
5837:
5834:
5831:
5826:
5825:
5824:
5821:
5816:
5815:
5814:
5811:
5809:
5806:
5801:
5800:
5799:
5796:
5791:
5790:
5789:
5786:
5781:
5780:
5779:
5775:
5772:
5771:
5769:
5767:
5766:
5761:
5758:
5756:
5750:
5747:
5745:
5739:
5734:
5730:
5727:
5720:
5715:
5713:
5708:
5706:
5701:
5700:
5697:
5690:
5685:
5680:
5678:
5668:
5667:
5664:
5650:
5646:
5645:
5641:
5639:
5635:
5634:
5630:
5628:
5624:
5623:
5619:
5618:
5615:
5611:
5604:
5600:
5599:
5595:
5593:
5589:
5588:
5584:
5582:
5578:
5577:
5573:
5571:
5567:
5566:
5562:
5560:
5556:
5555:
5551:
5547:
5545:
5541:
5540:
5536:
5532:
5530:
5526:
5522:
5518:
5517:
5513:
5509:
5508:
5505:
5500:
5496:
5490:
5486:
5481:
5477:
5476:
5471:
5466:
5465:
5452:
5448:
5444:
5440:
5436:
5432:
5428:
5424:
5420:
5413:
5397:
5393:
5387:
5371:
5367:
5363:
5357:
5341:
5337:
5333:
5327:
5311:
5307:
5303:
5297:
5289:
5283:
5279:
5273:
5257:
5253:
5247:
5245:
5243:
5234:
5230:
5225:
5220:
5216:
5212:
5208:
5204:
5200:
5193:
5191:
5182:
5178:
5173:
5168:
5164:
5160:
5156:
5152:
5148:
5144:
5140:
5133:
5125:
5121:
5116:
5111:
5107:
5103:
5098:
5093:
5089:
5085:
5081:
5074:
5066:
5062:
5057:
5052:
5048:
5044:
5040:
5036:
5032:
5028:
5024:
5017:
5009:
5005:
4999:
4995:
4994:
4986:
4978:
4974:
4968:
4964:
4963:
4955:
4953:
4951:
4949:
4932:
4928:
4924:
4917:
4906:
4902:
4898:
4893:
4888:
4883:
4878:
4874:
4870:
4863:
4856:
4847:
4832:
4828:
4822:
4815:
4811:
4807:
4802:
4797:
4792:
4787:
4783:
4779:
4775:
4768:
4752:
4748:
4744:
4739:
4734:
4730:
4726:
4722:
4718:
4711:
4704:
4693:
4689:
4685:
4680:
4675:
4670:
4665:
4661:
4657:
4650:
4643:
4635:
4631:
4626:
4621:
4617:
4613:
4610:(3): 480–96.
4609:
4605:
4601:
4594:
4592:
4590:
4588:
4586:
4584:
4575:
4571:
4566:
4561:
4557:
4553:
4549:
4542:
4527:
4523:
4517:
4501:
4497:
4491:
4483:
4479:
4475:
4471:
4466:
4461:
4457:
4453:
4449:
4442:
4434:
4430:
4425:
4420:
4416:
4412:
4408:
4404:
4397:
4390:
4382:
4378:
4372:
4368:
4364:
4357:
4355:
4346:
4340:
4324:
4317:
4309:
4305:
4300:
4295:
4291:
4287:
4283:
4276:
4268:
4264:
4259:
4254:
4250:
4246:
4242:
4238:
4234:
4230:
4226:
4222:
4218:
4211:
4196:
4192:
4185:
4183:
4167:
4163:
4156:
4148:
4144:
4140:
4136:
4132:
4128:
4124:
4120:
4113:
4111:
4109:
4089:
4085:
4078:
4072:
4056:
4052:
4048:
4041:
4039:
4022:
4018:
4014:
4008:
4006:
3989:
3985:
3981:
3976:
3971:
3967:
3963:
3959:
3952:
3950:
3948:
3931:
3927:
3923:
3917:
3910:
3898:
3894:
3888:
3884:
3883:
3875:
3873:
3856:
3852:
3848:
3841:
3825:
3821:
3817:
3811:
3795:
3791:
3790:
3785:
3779:
3763:
3759:
3755:
3749:
3733:
3729:
3725:
3719:
3700:
3696:
3689:
3683:
3667:
3663:
3659:
3653:
3637:
3633:
3629:
3623:
3621:
3619:
3602:
3598:
3594:
3588:
3586:
3577:
3573:
3569:
3564:
3559:
3556:(10): 19509.
3555:
3551:
3547:
3540:
3524:
3520:
3516:
3509:
3507:
3490:
3486:
3482:
3475:
3467:
3463:
3458:
3453:
3449:
3445:
3442:(4): 564–81.
3441:
3437:
3433:
3426:
3424:
3407:
3403:
3399:
3393:
3377:
3373:
3369:
3363:
3355:
3351:
3346:
3341:
3337:
3333:
3328:
3323:
3319:
3315:
3311:
3304:
3296:
3292:
3287:
3282:
3278:
3274:
3269:
3264:
3260:
3256:
3252:
3245:
3243:
3226:
3222:
3218:
3212:
3196:
3192:
3186:
3182:
3178:
3174:
3173:
3165:
3163:
3161:
3152:
3148:
3143:
3138:
3134:
3130:
3126:
3119:
3103:
3099:
3095:
3089:
3081:
3077:
3071:
3067:
3066:
3058:
3042:
3038:
3034:
3027:
3025:
3008:
3004:
2998:
2990:
2986:
2981:
2976:
2972:
2968:
2964:
2960:
2956:
2952:
2948:
2941:
2925:
2921:
2917:
2913:
2909:
2904:
2899:
2895:
2891:
2887:
2880:
2864:
2860:
2854:
2843:
2839:
2833:
2826:
2825:
2818:
2802:
2798:
2794:
2788:
2780:
2776:
2770:
2766:
2765:
2757:
2749:
2745:
2740:
2735:
2731:
2727:
2723:
2719:
2715:
2708:
2706:
2694:
2690:
2686:
2682:
2678:
2673:
2668:
2664:
2660:
2656:
2652:
2645:
2638:
2622:
2618:
2614:
2610:
2606:
2603:(7): 857–65.
2602:
2598:
2594:
2587:
2579:
2575:
2570:
2565:
2561:
2557:
2552:
2547:
2543:
2539:
2535:
2528:
2512:
2508:
2504:
2498:
2496:
2494:
2492:
2490:
2481:
2477:
2473:
2469:
2465:
2461:
2458:(1): 90–100.
2457:
2453:
2446:
2444:
2442:
2440:
2438:
2436:
2427:
2423:
2419:
2415:
2411:
2407:
2404:(5): 438–44.
2403:
2399:
2392:
2390:
2373:
2369:
2365:
2360:
2355:
2351:
2347:
2343:
2339:
2332:
2325:
2323:
2321:
2319:
2317:
2315:
2306:
2302:
2296:
2292:
2288:
2281:
2279:
2270:
2266:
2262:
2257:
2252:
2249:(10): 19509.
2248:
2244:
2240:
2233:
2231:
2222:
2218:
2214:
2210:
2205:
2200:
2196:
2192:
2185:
2178:
2176:
2174:
2157:
2153:
2149:
2143:
2135:
2131:
2127:
2123:
2119:
2115:
2111:
2107:
2100:
2092:
2088:
2083:
2078:
2074:
2070:
2067:(4): 376–96.
2066:
2062:
2058:
2051:
2035:
2031:
2027:
2021:
2002:
1998:
1994:
1987:
1981:
1965:
1961:
1957:
1951:
1949:
1932:
1928:
1924:
1918:
1916:
1914:
1897:
1893:
1889:
1885:
1884:
1876:
1860:
1856:
1852:
1846:
1844:
1835:
1831:
1826:
1821:
1817:
1813:
1809:
1805:
1801:
1794:
1778:
1774:
1770:
1764:
1762:
1760:
1758:
1756:
1739:
1735:
1728:
1720:
1716:
1710:
1706:
1705:
1698:
1691:
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1676:
1672:
1669:
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1656:
1652:
1648:
1644:
1640:
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1632:
1628:
1621:
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1615:
1613:
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1607:
1590:
1586:
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1574:
1572:
1570:
1568:
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1560:
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1525:
1522:
1520:
1517:
1516:
1510:
1502:
1499:
1496:
1494:
1490:
1486:
1478:
1473:
1464:
1462:
1447:
1444:
1442:
1438:
1434:
1424:
1422:
1418:
1417:Benjamin Rush
1415:
1411:
1406:
1404:
1400:
1396:
1392:
1391:ki-dinga pepo
1388:
1384:
1380:
1370:
1366:
1362:
1360:
1356:
1351:
1347:
1342:
1340:
1336:
1332:
1328:
1324:
1323:Aedes aegypti
1319:
1317:
1307:
1304:
1302:
1298:
1292:
1290:
1289:
1284:
1280:
1276:
1275:
1274:Aedes aegypti
1269:
1267:
1258:
1249:
1244:
1239:
1236:
1233:
1186:
1181:
1171:
1162:
1160:
1156:
1151:
1149:
1144:
1142:
1138:
1134:
1130:
1126:
1125:Acetaminophen
1121:
1113:
1111:
1107:
1103:
1099:
1094:
1086:
1082:
1080:
1076:
1072:
1068:
1064:
1060:
1056:
1052:
1042:
1040:
1036:
1032:
1028:
1024:
1020:
1015:
1013:
1012:Severe dengue
1009:
1005:
995:
993:
988:
984:
980:
978:
974:
966:
962:
958:
948:
945:
941:
937:
933:
929:
925:
920:
916:
914:
907:
898:
884:
881:
877:
873:
869:
865:
861:
856:
854:
850:
846:
842:
841:keratinocytes
832:
830:
820:
816:
814:
810:
804:
802:
798:
794:
783:
781:
777:
773:
768:
765:
760:
755:
753:
749:
745:
744:
739:
738:
733:
732:
727:
723:
722:
717:
716:
707:
706:Aedes aegypti
704:The mosquito
702:
693:
691:
687:
683:
679:
675:
671:
667:
663:
659:
655:
651:
650:
645:
644:
639:
631:
627:
624:
619:
614:
599:
597:
593:
589:
585:
584:Complications
567:
559:when pressed.
558:
551:
542:
540:
536:
531:
529:
525:
521:
517:
513:
508:
506:
502:
498:
497:severe dengue
493:
491:
486:
478:
474:
472:
468:
454:
440:
426:
424:
419:
414:
411:
407:
406:
405:Aedes aegypti
401:
398:
397:
392:
387:
385:
384:intravenously
379:
377:
373:
369:
365:
361:
356:
352:
347:
345:
342:leakage, and
341:
337:
333:
329:
328:severe dengue
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
282:
278:
269:
265:
261:
257:
254:
250:
246:
243:
239:
235:
232:
228:
225:
224:leptospirosis
221:
217:
213:
210:
208:
204:
201:
197:
193:
191:
187:
184:
181:
180:
175:
172:
168:
164:
160:
156:
152:
149:
145:
141:
138:
136:
135:Complications
132:
128:
126:
122:
119:
116:
114:
110:
101:
66:
65:
63:
61:Pronunciation
59:
54:
50:
45:
41:
37:
32:
26:
22:
6979:Dengue fever
6939:
6930:Mokola virus
6907:
6869:
6841:Retroviridae
6839:
6827:
6817:
6765:
6733:
6686:
6627:
6600:
6590:
6523:Bunyavirales
6521:
6438:Arenaviridae
6436:
6386:
6338:Bunyavirales
6336:
6291:
6271:
6257:Langat virus
6191:Flaviviridae
6189:
6180:Bhanja virus
6137:Bunyavirales
6135:
6100:
6000:
5972:Yellow fever
5960:Dengue fever
5959:
5880:Flaviviridae
5878:
5823:Tahyna virus
5788:Bwamba Fever
5765:Bunyavirales
5763:
5649:Dengue fever
5642:
5631:
5620:
5596:
5585:
5574:
5563:
5548:
5533:
5510:
5485:Dengue fever
5473:
5426:
5422:
5412:
5400:. Retrieved
5396:the original
5386:
5374:. Retrieved
5365:
5356:
5344:. Retrieved
5340:the original
5335:
5326:
5314:. Retrieved
5305:
5296:
5277:
5272:
5260:. Retrieved
5256:the original
5209:(2): 66–77.
5206:
5203:Transfus Med
5202:
5146:
5142:
5132:
5087:
5083:
5073:
5030:
5026:
5016:
4992:
4985:
4961:
4935:. Retrieved
4926:
4916:
4872:
4868:
4855:
4846:
4834:. Retrieved
4830:
4821:
4813:
4781:
4777:
4767:
4757:24 September
4755:. Retrieved
4738:11343/191104
4720:
4716:
4703:
4659:
4655:
4642:
4607:
4603:
4558:(2): 37–45.
4555:
4551:
4541:
4529:. Retrieved
4525:
4516:
4504:. Retrieved
4499:
4490:
4455:
4451:
4441:
4424:11343/191104
4406:
4402:
4389:
4366:
4327:. Retrieved
4316:
4292:(2): 37–45.
4289:
4285:
4275:
4224:
4220:
4210:
4198:. Retrieved
4195:patient.info
4194:
4169:. Retrieved
4165:
4155:
4122:
4118:
4095:. Retrieved
4083:
4071:
4059:. Retrieved
4050:
4025:. Retrieved
4016:
3992:. Retrieved
3965:
3961:
3934:. Retrieved
3925:
3916:
3908:
3901:. Retrieved
3881:
3859:. Retrieved
3850:
3840:
3828:. Retrieved
3819:
3810:
3798:. Retrieved
3787:
3778:
3766:. Retrieved
3757:
3748:
3736:. Retrieved
3727:
3718:
3706:. Retrieved
3694:
3682:
3670:. Retrieved
3661:
3652:
3640:. Retrieved
3631:
3605:. Retrieved
3596:
3553:
3549:
3539:
3527:. Retrieved
3518:
3493:. Retrieved
3484:
3474:
3439:
3435:
3410:. Retrieved
3401:
3392:
3380:. Retrieved
3371:
3362:
3317:
3313:
3303:
3258:
3254:
3229:. Retrieved
3220:
3211:
3199:. Retrieved
3171:
3135:(1): 51–54.
3132:
3128:
3118:
3106:. Retrieved
3097:
3088:
3064:
3057:
3045:. Retrieved
3036:
3011:. Retrieved
3007:the original
2997:
2954:
2950:
2940:
2928:. Retrieved
2893:
2889:
2879:
2867:. Retrieved
2863:the original
2853:
2823:
2817:
2805:. Retrieved
2796:
2787:
2763:
2756:
2721:
2717:
2654:
2650:
2637:
2625:. Retrieved
2600:
2596:
2586:
2541:
2537:
2527:
2515:. Retrieved
2506:
2455:
2451:
2401:
2397:
2378:24 September
2376:. Retrieved
2359:11343/191104
2341:
2337:
2290:
2246:
2242:
2194:
2190:
2160:. Retrieved
2151:
2142:
2109:
2105:
2099:
2064:
2060:
2050:
2038:. Retrieved
2029:
2020:
2008:. Retrieved
1996:
1992:
1980:
1968:. Retrieved
1959:
1935:. Retrieved
1926:
1900:. Retrieved
1883:Dengue Fever
1882:
1875:
1863:. Retrieved
1854:
1807:
1803:
1793:
1781:. Retrieved
1772:
1742:. Retrieved
1727:
1703:
1697:
1663:
1630:
1626:
1593:. Retrieved
1584:
1508:
1500:
1497:
1482:
1475:A poster in
1461:blood donors
1458:
1445:
1433:pathogenesis
1430:
1421:Philadelphia
1409:
1407:
1394:
1390:
1386:
1382:
1376:
1367:
1363:
1343:
1339:Philadelphia
1322:
1320:
1313:
1305:
1297:urbanization
1293:
1286:
1282:
1272:
1270:
1266:hyperendemic
1263:
1229:
1174:Epidemiology
1168:
1152:
1145:
1122:
1119:
1095:
1091:
1066:
1048:
1016:
1011:
1001:
982:
981:
972:
971:
960:
932:insecticides
923:
921:
917:
909:
880:blood volume
857:
838:
825:
805:
789:
786:Risk factors
774:and through
769:
756:
741:
735:
729:
725:
719:
713:
711:
705:
696:Transmission
690:antigenicity
647:
643:Flaviviridae
641:
635:
613:Dengue virus
582:
532:
509:
504:
500:
496:
494:
487:
484:
475:
467:asymptomatic
464:
415:
403:
394:
388:
380:
348:
340:blood plasma
327:
300:asymptomatic
288:dengue virus
277:Dengue fever
276:
275:
216:yellow fever
177:
174:Dengue virus
34:Dengue fever
25:
6629:Filoviridae
6451:Lassa fever
6347:Adria virus
6045:Chikungunya
6002:Togaviridae
5932:Usutu virus
5854:Ngari virus
5778:Batai virus
5622:MedlinePlus
5468:‹ The
4937:25 December
4017:Mayo Clinic
3861:29 February
3830:28 February
3758:www.cdc.gov
3495:23 December
3412:28 February
3382:29 February
3231:23 February
3201:23 February
3108:28 February
3047:23 December
2807:25 February
2517:25 February
2507:Mayo Clinic
2162:13 February
2040:14 February
1970:13 February
1937:14 February
1902:13 February
1865:14 February
1783:13 February
1595:10 February
1437:diagnostics
1355:Philippines
1327:slave trade
1224: 9–561
1155:dehydration
1102:NS1 antigen
1059:chikungunya
872:bone marrow
864:interferons
849:lymph nodes
594:birth, and
588:miscarriage
522:as well as
320:joint pains
296:subtropical
154:Usual onset
39:Other names
6973:Categories
6941:Poxviridae
6871:Poxviridae
6791:SARS-CoV-2
6293:Reoviridae
6171:Tete virus
6102:Reoviridae
5984:Zika fever
5833:Tete virus
5731:(A80–B34,
5644:Patient UK
5587:DiseasesDB
5090:(4): 180.
4875:(6): 893.
4662:(6): 893.
4458:: 161–73.
4325:. Medscape
3013:17 January
2957:: 100216.
2951:One Health
2627:5 December
2197:: 161–73.
1744:17 October
1530:References
1283:A. aegypti
1178:See also:
1159:hematocrit
1079:subtropics
992:attenuated
944:pyrethroid
924:A. aegypti
913:permethrin
887:Prevention
662:Zika virus
649:Flavivirus
626:micrograph
490:high fever
391:mosquitoes
376:antibodies
286:caused by
230:Prevention
196:antibodies
194:Detecting
6950:Monkeypox
5742:Arthropod
5633:eMedicine
5598:SNOMED CT
5443:1473-3099
5402:7 January
5376:7 January
5346:7 January
5316:7 January
5163:2049-9361
5106:2414-6366
5047:0022-1899
4831:Yale E360
4574:2414-6447
4482:215154729
4308:2414-6447
4249:0028-0836
4125:: h4661.
3984:0185-1063
3336:1553-7374
3277:1553-7366
2971:2352-7714
2920:205949828
2869:27 August
2560:1935-2735
2221:215154729
2134:267201333
1816:1752-8526
1633:: h4661.
1441:antiviral
1408:The term
1379:Kiswahili
1373:Etymology
1218: 4–8
1165:Prognosis
1137:ibuprofen
1116:Treatment
1051:Influenza
1045:Diagnosis
973:Dengvaxia
860:cytokines
686:serotypes
638:RNA virus
512:platelets
364:influenza
351:serotypes
324:skin rash
259:Frequency
241:Treatment
183:mosquitos
113:Specialty
6999:Zoonoses
6898:Multiple
6786:SARS-CoV
6776:MERS-CoV
5965:DENV-1-4
5753:Mosquito
5726:Zoonotic
5677:Medicine
5603:38362002
5470:template
5451:27091092
5370:Archived
5310:Archived
5233:19392949
5181:37114191
5172:10126642
5124:34698303
5065:22782946
5008:Archived
4977:Archived
4931:Archived
4905:Archived
4901:29398958
4836:20 March
4810:26562299
4751:Archived
4747:22494122
4710:"Dengue"
4692:Archived
4688:29398958
4531:17 March
4506:17 March
4474:20616106
4448:"Dengue"
4433:22494122
4396:"Dengue"
4381:Archived
4339:cite web
4267:23563266
4200:14 March
4171:17 March
4139:26374064
4097:10 March
4088:Archived
4061:10 March
4055:Archived
4051:Medscape
4027:10 March
4021:Archived
3988:Archived
3930:Archived
3897:Archived
3855:Archived
3824:Archived
3794:Archived
3762:Archived
3732:Archived
3699:Archived
3666:Archived
3636:Archived
3601:Archived
3576:Archived
3572:20403310
3523:Archived
3489:Archived
3466:19822889
3406:Archived
3376:Archived
3354:36996026
3345:10062565
3295:36996026
3286:10062565
3225:Archived
3195:Archived
3151:20130380
3102:Archived
3080:Archived
3041:Archived
2989:33598525
2924:Archived
2912:18262042
2842:Archived
2801:Archived
2779:Archived
2748:21079655
2693:Archived
2681:20372965
2672:11115823
2621:Archived
2617:26949028
2578:35981059
2511:Archived
2480:10135251
2472:20639791
2418:20581669
2372:Archived
2368:22494122
2331:"Dengue"
2305:Archived
2269:Archived
2265:20403310
2213:20616106
2184:"Dengue"
2156:Archived
2126:38280388
2034:Archived
2010:12 April
2001:Archived
1964:Archived
1931:Archived
1896:Archived
1892:28613483
1859:Archived
1834:25860404
1810:: 0917.
1777:Archived
1738:Archived
1719:Archived
1671:Archived
1647:26374064
1589:Archived
1513:See also
1477:Tampines
1427:Research
928:habitats
870:and the
752:primates
672:, which
646:; genus
607:Virology
557:blanches
355:immunity
332:bleeding
312:vomiting
308:headache
292:tropical
165:2–7 days
162:Duration
140:Bleeding
125:Symptoms
6900:vectors
6880:Tanapox
6829:B virus
6807:Primate
6326:Sandfly
6152:(CCHFV)
5733:042–079
5689:Viruses
5663:Portals
5638:med/528
5581:D003715
5472:below (
5262:16 June
5224:2713854
5115:8544673
5056:3499110
4892:3373045
4801:4643049
4679:3373045
4634:9665979
4329:23 June
4258:3651993
4229:Bibcode
4147:1680504
3994:7 March
3936:4 March
3903:7 March
3800:8 March
3768:8 March
3738:9 March
3708:9 March
3672:8 March
3642:8 March
3607:8 March
3529:8 March
3457:2772360
2980:7868715
2739:4333201
2689:4232236
2569:9426910
2426:2452280
2091:2224837
1825:4392842
1736:. CNN.
1655:1680504
1493:Vietnam
1485:Jakarta
1331:Jakarta
1310:History
1232:endemic
1212: 3
1206: 2
1200: 1
1194: 0
1133:aspirin
1129:Tylenol
1075:tropics
1055:measles
1031:abdomen
951:Vaccine
759:viremic
630:virions
535:itching
418:endemic
393:of the
360:malaria
284:disease
212:Malaria
6918:Rabies
6860:HTLV-2
6855:HTLV-1
6809:-borne
6697:Rabies
6619:-borne
6428:-borne
6426:Rodent
6417:-borne
6415:Mammal
6349:(ADRV)
6328:-borne
6127:-borne
5755:-borne
5744:-borne
5627:001374
5570:614371
5489:Curlie
5475:Curlie
5449:
5441:
5284:
5231:
5221:
5179:
5169:
5161:
5122:
5112:
5104:
5063:
5053:
5045:
5000:
4969:
4899:
4889:
4808:
4798:
4745:
4686:
4676:
4632:
4622:
4572:
4480:
4472:
4431:
4373:
4306:
4265:
4255:
4247:
4221:Nature
4145:
4137:
3982:
3889:
3570:
3464:
3454:
3352:
3342:
3334:
3293:
3283:
3275:
3187:
3149:
3072:
2987:
2977:
2969:
2930:6 June
2918:
2910:
2890:Lancet
2834:
2771:
2746:
2736:
2687:
2679:
2669:
2615:
2576:
2566:
2558:
2478:
2470:
2424:
2416:
2366:
2297:
2263:
2219:
2211:
2132:
2124:
2106:Lancet
2089:
2082:358169
2079:
1890:
1832:
1822:
1814:
1711:
1690:dengue
1668:dengue
1653:
1645:
1489:Yangon
1395:dengue
1337:, and
1222:
1216:
1210:
1204:
1198:
1192:
1061:, and
983:Qdenga
815:(ADE).
666:genome
660:, and
537:and a
366:, and
316:muscle
267:Deaths
170:Causes
104:
6658:ZEBOV
6562:THAIV
6050:CHIKV
4908:(PDF)
4897:S2CID
4865:(PDF)
4713:(PDF)
4695:(PDF)
4684:S2CID
4652:(PDF)
4625:88892
4478:S2CID
4399:(PDF)
4143:S2CID
4091:(PDF)
4080:(PDF)
3702:(PDF)
3691:(PDF)
2916:S2CID
2845:(PDF)
2828:(PDF)
2696:(PDF)
2685:S2CID
2647:(PDF)
2476:S2CID
2422:S2CID
2334:(PDF)
2217:S2CID
2187:(PDF)
2130:S2CID
2004:(PDF)
1989:(PDF)
1651:S2CID
1403:dandy
1387:denga
1383:dinga
1381:term
1335:Cairo
1279:tanks
1098:ELISA
1067:Aedes
1037:, or
1027:lungs
868:liver
726:Aedes
715:Aedes
602:Cause
516:chest
400:genus
396:Aedes
374:, or
304:fever
279:is a
179:Aedes
6923:RABV
6724:CHPV
6712:DUVV
6707:MOKV
6702:ABLV
6675:RAVV
6670:MARV
6653:TAFV
6648:SUDV
6643:BDBV
6574:ANDV
6557:AMRV
6552:SEOV
6547:PUUV
6542:HTNV
6537:DOBV
6512:CHPV
6507:LUJV
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