306:
283:
29:
523:
20 with metronidazole. One-fourth of the patients treated with dehydroemetine reported adverse reactions, compared to 20% with other drugs, but no patient discontinued therapy due to the reaction. In all three cases, the drug therapy resulted in clearance of the infection, defined as negative results through an O&P exam, in all but 1-2 patients.
561:, a condition which can produce painful neurological symptoms. The study involved 40 patients, all of whom were over 60, and compared dehydroemetine treatment to another drug. The study reported patients treated with dehydroemetine experienced relief of neuralgia with no changes in cardiovascular functions.
522:
A double-blind study of oral dehydroemetine in the treatment of amoebiasis performed at St. Mary's
Hospital, Catholic Medical College, Seoul, Republic of Korea in 1973-1974 showed dehydroemetine treatment was effective. A total of 60 patients were treated, 20 with dehydroemetine, 20 with Tiberal, and
375:
461:
in its anti-amoebic properties and structure (they differ only in a double bond next to the ethyl substituent), but it produces fewer side effects. In the United States, it is manufactured by
737:
Chintana T, Sucharit P, Mahakittikun V, Siripanth C, Suphadtanaphongs W (December 1986). "In vitro studies on the sensitivity of local
Entamoeba histolytica to anti-amoebic drugs".
417:
InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,24-25,30H,6-12,17H2,1-5H3/t24-,25+/m1/s1
528:
A 1979 study of 27 patients treated with dehydroemetine and various other drugs suggested all drug combinations were successful at treating amoebic liver abscesses.
59:
710:
Peters M, Dietrich M, Bienzle U, Kern P, Mannweiler E (December 1979). "Amoebic liver abscess: a retrospective clinical evaluation of twenty-seven cases".
894:
433:
41:
389:
681:"Amoebic Comparative Double Blind Trials of Tiberal Compared with Metronidazole and Oral Dehydroemetine in Oligosymptomatie Amoebiasis"
680:
872:
611:
887:
842:
Al-Khateeb GH, Al-Jeboori TI, Al-Janabi KA (1977). "In vitro efficacy of some drugs on promastigotes of
Leishmania donovani".
1262:
440:
880:
595:
409:
1279:
1306:
92:
815:
Hernandez-Perez E (April 1980). "Dehydroemetine therapy for herpes zoster. A comparison with corticosteroids".
1316:
1311:
531:
A 1986 in vitro study compared the effects of dehydroemetine, metronidazole, ornidazole, and secnidazole on
301:
182:
1235:
262:
251:
537:. Metronidazole was found to be most effective, and the other three drugs were of similar effectiveness.
488:
764:
Panwar P, Burusco KK, Abubaker M, Matthews H, Gutnov A, FernĂĄndez-Ălvaro E, et al. (March 2020).
278:
902:
1267:
1062:
492:
533:
462:
231:
691:(1). The Korean Society of Infectious Diseases & Korean Society for Chemotherapy: 97â104
511:
Some examples of the use of dehydroemetine in the treatment of amoebic infections include:
496:
191:
171:
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126:
51:
8:
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937:
907:
516:
454:
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Magaña-GarcĂa M, Arista-Viveros A (December 1993). "Cutaneous amebiasis in children".
615:
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855:
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1108:
1103:
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915:
911:
766:"Lead Optimization of Dehydroemetine for Repositioned Use in Malaria"
736:
519:
in a 7-year-old girl with dehydroemetine and metronidazole in Mexico.
137:
45:
1206:
1113:
475:
211:
739:
The
Southeast Asian Journal of Tropical Medicine and Public Health
557:
A 1980 report described the use of dehydroemetine in treatment of
374:
1151:
1005:
551:
458:
28:
397:
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242:
841:
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614:. Centers for Disease Control and Prevention. Archived from
267:
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202:
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104:)-2-methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1
564:
Dehydroemetine has been investigated as a treatment for
487:
It was at one-time, but is no longer distributed by the
590:. Washington, DC: Taylor & Francis. p. 47.
588:
Handbook of drugs for tropical parasitic infections
1298:
579:
150:
814:
125:
550:study found dehydroemetine to be effective in
888:
757:
612:"Center for Disease Control NCID Formulary"
895:
881:
808:
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678:
629:
604:
304:
281:
170:
27:
791:
781:
703:
190:
835:
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1299:
473:Its exact mechanism is not known, but
295:
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770:Antimicrobial Agents and Chemotherapy
515:In 1993, the successful treatment of
506:
250:
230:
50:
672:
585:
541:
71:
210:
141:
13:
679:Chun CH, Park PW, Lee OJ, Pak SY.
650:10.1111/j.1525-1470.1993.tb00397.x
14:
1328:
335:
329:
712:Tropenmedizin und Parasitologie
422:Key:XXLZPUYGHQWHRN-RPBOFIJWSA-N
341:
323:
1:
573:
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453:is a synthetically produced
7:
479:it inhibits translocation.
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489:Center for Disease Control
313:Chemical and physical data
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40:
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26:
52:International Drug Names
910: â agents against
685:Korean Medical Database
503:-resistant amoebiasis.
482:
1307:Isoquinoline alkaloids
1063:Diiodohydroxyquinoline
638:Pediatric Dermatology
534:Entamoeba histolytica
499:for the treatment of
1317:Norsalsolinol ethers
1312:Antiprotozoal agents
908:antiprotozoal agents
783:10.1128/AAC.01444-19
497:investigational drug
517:cutaneous amebiasis
455:antiprotozoal agent
108:-pyridoisoquinoline
23:
1284:Never to phase III
1025:Luminal amebicides
618:on 9 February 2006
507:Amoebic infections
19:
1294:
1293:
1230:
1229:
1140:
1139:
1090:Dichloroacetamide
1019:
1018:
938:Tissue amebicides
856:10.1159/000221994
542:In other diseases
493:compassionate use
448:
447:
376:Interactive image
263:CompTox Dashboard
16:Chemical compound
1324:
1034:Hydroxyquinoline
1030:
1029:
943:
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586:Abdi YA (1995).
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1274:Clinical trials
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1145:Other/ungrouped
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1177:phenanthroline
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1142:
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1124:Aminoglycoside
1120:
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1111:
1106:
1101:
1095:
1093:
1086:
1085:
1083:
1082:
1075:
1074:
1066:
1059:
1056:Broxyquinoline
1053:
1047:
1044:Chlorquinaldol
1039:
1037:
1027:
1021:
1020:
1017:
1016:
1014:
1013:
1010:Dehydroemetine
998:
996:
992:
991:
989:
988:
983:
978:
973:
968:
963:
958:
952:
950:
947:Nitroimidazole
940:
931:
925:
924:
904:Antiparasitics
900:
899:
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885:
877:
870:
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850:(4): 267â275.
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543:
540:
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451:Dehydroemetine
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21:Dehydroemetine
15:
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1249:Chlorhexidine
1247:
1245:
1242:
1241:
1239:
1237:
1233:
1222:
1218:
1217:sesquiterpene
1215:
1212:
1211:Tenonitrozole
1208:
1205:
1202:
1198:
1195:
1192:
1188:
1187:aminoacridine
1185:
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956:Metronidazole
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597:0-7484-0168-7
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559:herpes zoster
555:
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501:metronidazole
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296:ECHA InfoCard
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36:Clinical data
34:
30:
25:
1236:Acanthamoeba
1201:Trimetrexate
1171:Glycobiarsol
1051:Tilbroquinol
1009:
1002:isoquinoline
847:
844:Chemotherapy
843:
837:
820:
816:
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773:
769:
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738:
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693:. Retrieved
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620:. Retrieved
616:the original
606:
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510:
495:basis as an
486:
474:
472:
450:
449:
438:
432:
252:ChEMBL547470
105:
101:
1270:from market
1244:Propamidine
1197:quinazoline
1181:Phanquinone
1166:Difetarsone
1132:Paromomycin
1092:derivatives
1036:derivatives
981:Azanidazole
976:Secnidazole
949:derivatives
695:November 9,
570:infection.
457:similar to
359: g·mol
302:100.023.220
84:Identifiers
1301:Categories
1221:Fumagillin
1161:Carbarsone
1099:Diloxanide
1070:Clioquinol
971:Nimorazole
966:Ornidazole
961:Tinidazole
622:2007-09-09
574:References
567:Leishmania
364:3D model (
352:Molar mass
232:CHEBI:4363
192:7S79QT1T91
163:ChemSpider
118:CAS Number
93:IUPAC name
1280:Phase III
1268:Withdrawn
1191:Mepacrine
1156:Arsthinol
1109:Etofamide
1104:Clefamide
1080:Chiniofon
1078:related:
929:Entamoeba
916:amebicide
912:amoebozoa
469:Mechanism
127:4914-30-1
46:Drugs.com
1207:thiazole
1114:Teclozan
906: â
802:31964796
666:41438097
548:in-vitro
476:in vitro
441:(verify)
60:ATC code
1152:arsenic
1068:I, Cl (
1006:Emetine
829:6102504
793:7179302
751:2883732
658:8302738
552:malaria
546:A 2020
459:emetine
357:478.633
319:Formula
138:PubChem
76:)
70: (
68:P01AX09
1263:WHO-EM
862:
827:
800:
790:
749:
724:538815
722:
664:
656:
594:
390:SMILES
243:ChEMBL
212:D00828
995:Other
864:16732
817:Cutis
662:S2CID
491:on a
463:Roche
410:InChI
366:JSmol
223:ChEBI
172:19773
152:21022
1049:Br (
1042:Cl (
860:PMID
825:PMID
798:PMID
747:PMID
720:PMID
697:2015
654:PMID
592:ISBN
483:Uses
203:KEGG
183:UNII
100:(11b
42:AHFS
1061:I (
920:P01
852:doi
788:PMC
778:doi
646:doi
268:EPA
142:CID
73:WHO
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330:H
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