1030:, PAH). Symptoms of PAH may include shortness of breath, fatigue, and swelling of the body (such as the ankles and legs). In reported cases, people developed PAH after starting dasatinib, including after more than one year of treatment. Information about the risk was added to the Warnings and Precautions section of the Sprycel drug label. In studies between 2009 and 2017 dasatinib-induced PAH was initiated between 0.3 and 74 months of daily drug usage at doses from 70 to 140 mg. Reported dasatinib-induced PAH had improvements after cessation of drug treatment.
612:
589:
40:
1039:
31:
7810:
2004:
1955:
1581:
1304:
1144:
The Union for
Affordable Cancer Treatment objected to the price of dasatinib, in a letter to the U.S. trade representative. The average wholesale price in the U.S. is $ 367 per day, twice the price in other high income countries. The price in India, where the average annual per capita income is $
1131:
Approval was based on data from 97 pediatric participants with chronic phase CML evaluated in two trials—a Phase I, open-label, non-randomized, dose-ranging trial and a Phase II, open-label, non-randomized trial. Fifty-one participants exclusively from the Phase II trial were newly diagnosed with
2206:
Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, et al. (December 2004). "Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor
1148:
Bristol-Myers Squibb justified the high prices of cancer drugs with the high R&D costs, but the Union of
Affordable Cancer Treatment said that most of the R&D costs came from the U.S. government, including National Institutes of Health funded research and clinical trials, and a 50% tax
1823:
1145:
1,570, and where most people pay out of pocket, is Rs6627 ($ 108) a day. Indian manufacturers offered to supply generic versions for $ 4 a day, but, under pressure from the U.S., the Indian
Department of Industrial Policy and Promotion refused to issue a compulsory license.
1470:
1132:
chronic phase CML and 46 participants (17 from the Phase I trial and 29 from the Phase II trial) were resistant or intolerant to previous treatment with imatinib. The majority of participants were treated with dasatinib tablets 60 mg/m
1853:
1104:
and Otsuka
Pharmaceutical Co., Ltd, and named for Bristol-Myers Squibb research fellow Jagabandhu Das, whose program leader says that the drug would not have come into existence had he not challenged some of the
1478:
1815:
1845:
1816:"FDA Approves U.S. Product Labeling Update for Sprycel (dasatinib) to Include Three-Year First-Line and Five-Year Second-Line Efficacy and Safety Data in Chronic Myeloid Leukemia in Chronic Phase"
1125:
In
October 2010, dasatinib was approved in the United States for the treatment of newly diagnosed adults with Philadelphia chromosome positive chronic myeloid leukemia in chronic phase (CP-CML).
1128:
In
November 2017, dasatinib was approved in the United States for the treatment of children with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in the chronic phase.
878:
newly diagnosed
Philadelphia chromosome-positive chronic myelogenous leukaemia in chronic phase (Ph+ CML CP) or Ph+ CML CP resistant or intolerant to prior therapy including imatinib.
248:
147:
5919:
1558:
729:
InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
1095:
5939:
2277:
1215:(a disease characterized by increased numbers of senescent cells) given dasatinib and quercetin showed improved physical function and evidence of reduced senescent cells.
5929:
3708:
4084:
1026:(FDA) announced that dasatinib may increase the risk of a rare but serious condition in which there is abnormally high blood pressure in the arteries of the lungs (
687:
7880:
5914:
1152:
The Union for
Affordable Cancer Treatment said that "the dasatinib dispute illustrates the shortcomings of US trade policy and its impact on cancer patients"
203:
4449:
1149:
credit. In
England and Wales, the National Institute for Health and Care Excellence recommended against dasatinib because of the high cost-benefit ratio.
1652:"The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants"
745:
7571:
7850:
7840:
7551:
5684:
3759:
2270:
1074:, and several other tyrosine kinases. Strong inhibition of the activated BCR-ABL kinase distinguishes dasatinib from other CML treatments, such as
113:
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4800:
3992:
3701:
7641:
7586:
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4725:
1981:
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7531:
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6307:
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6119:
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2711:
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62:
7272:
7267:
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4690:
4685:
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4419:
4347:
4326:
4311:
4264:
3917:
701:
1696:"Nephrotoxicity Associated with Novel Anticancer Agents (Aflibercept, Dasatinib, Nivolumab): Case Series and Nephrological Considerations"
6402:
6260:
6239:
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6094:
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5789:
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6069:
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6185:
6084:
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5883:
5835:
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5814:
5759:
5729:
5209:
5199:
5151:
5133:
5062:
4896:
4735:
4680:
2026:
Cohen D (November 2014). "US trade rep is pressing Indian government to forbid production of generic cancer drug, consortium says".
7035:
5924:
5614:
1846:"Bristol-Myers Squibb Announces Extension of U.S. Agreement for ABILIFY and Establishment of an Oncology Collaboration with Otsuka"
1506:
1232:
5219:
4936:
3269:
2912:
884:
newly diagnosed Ph+ CML in chronic phase (Ph+ CML-CP) or Ph+ CML-CP resistant or intolerant to prior therapy including imatinib.
6024:
4204:
3887:
7090:
6652:
6602:
6552:
6523:
6470:
4957:
4824:
1802:"Otsuka and Bristol-Myers Squibb Announce a Change in Contract Regarding Collaboration in Japan in the Oncology Therapy Area"
848:
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6281:
6277:
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3822:
3806:
2405:
4550:
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4336:
4253:
6265:
3383:
1902:
1208:
function and eliminated senescent cells. Aged mice given dasatinib with quercetin showed improved health and survival.
5954:
5073:
4633:
4244:
1386:
Keating GM (January 2017). "Dasatinib: A Review in
Chronic Myeloid Leukaemia and Ph+ Acute Lymphoblastic Leukaemia".
752:
721:
143:
130:
1932:
895:
chronic, accelerated or blast phase CML with resistance or intolerance to prior therapy including imatinib mesilate;
3902:
3846:
3837:
2803:
2329:
1240:
6476:
1012:
361:
233:
94:
892:
newly diagnosed Philadelphia-chromosome-positive (Ph+) chronic myelogenous leukaemia (CML) in the chronic phase;
7860:
6563:
6539:
5679:
5235:
5098:
1876:
898:
Ph+ acute lymphoblastic leukaemia (ALL) and lymphoid blast CML with resistance or intolerance to prior therapy.
437:
6529:
1212:
1122:
Dasatinib was approved for used in the United States in June 2006 and in the European Union in November 2006
847:
Dasatinib was approved for medical use in the United States and in the European Union in 2006. It is on the
6877:
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1987:
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1908:
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607:
488:
7085:
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6867:
5944:
3330:
2306:
568:
2255:
7800:
6782:
6558:
4384:
3455:
3304:
3053:
2555:
557:
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7830:
6645:
6466:
2780:
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2359:
1358:
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1055:
829:
108:
1880:
7227:
7145:
7040:
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4650:
4566:
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4352:
4269:
2790:
2316:
983:
were common toxic effects. Fifteen people (of 84, i.e. 18%) in the above-mentioned study developed
960:
860:
584:
6250:
3997:
3872:
2286:
2156:
1109:' underlying assumptions at a time when progress in the development of the molecule had stalled.
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868:
782:
184:
52:
1801:
7702:
6534:
6150:
6054:
5674:
5093:
4079:
3717:
3158:
2641:
2370:
1165:
1086:
of three to five hours, the strong binding to BCR-ABL1 results in a longer duration of action.
1027:
304:
537:
7855:
7845:
7370:
7327:
6608:
4805:
4089:
3728:
2716:
2656:
2626:
2529:
2365:
1756:
1650:
Tokarski JS, Newitt JA, Chang CY, Cheng JD, Wittekind M, Kiefer SE, et al. (June 2006).
821:
797:
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428:
1282:
995:
to treat the effusions. Other adverse events included mild to moderate diarrhea, peripheral
392:
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6679:
6638:
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5934:
4866:
4815:
2571:
2466:
2303:
1101:
1083:
1004:
497:
326:
1136:
once daily. Participants were treated until disease progression or unacceptable toxicity.
8:
7443:
7410:
5689:
5103:
3424:
2691:
2681:
2501:
2244:
1177:
936:
881:
newly diagnosed Ph+ acute lymphoblastic leukaemia (ALL) in combination with chemotherapy.
801:
786:
383:
191:
611:
588:
7875:
7070:
6897:
6787:
6684:
5367:
3720:
3079:
2616:
2178:
2151:
2124:
2097:
2051:
1778:
1751:
1724:
1695:
1627:
1602:
1528:
1501:
1411:
1205:
1011:
was also noted, but did not appear to cause any significant problems. Several cases of
158:
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7100:
5994:
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2224:
2183:
2129:
2055:
2043:
1783:
1729:
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1632:
1533:
1452:
1415:
1403:
1133:
1106:
1043:
841:
274:
261:
195:
86:
39:
3686:
417:
7662:
7626:
7621:
7192:
7065:
7060:
7027:
6857:
6714:
6689:
6412:
5544:
2596:
2438:
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2216:
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2165:
2119:
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2035:
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1719:
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1395:
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984:
980:
932:
833:
770:
624:
296:
216:
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1651:
1168:. In India, It is marketed under the brand name Nextki by Emcure Pharmaceuticals.
7814:
7636:
2069:
1336:
1071:
813:
314:
72:
1769:
987:, which was a suspected side effect of dasatinib. Some of these people required
7687:
7646:
7197:
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6155:
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5999:
5113:
5108:
3754:
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2903:
2686:
2651:
2471:
2451:
2008:
1959:
1585:
1308:
1193:
1015:(PAH) were found in people treated with dasatinib, possibly due to pulmonary
988:
817:
600:
2169:
1447:
1430:
1038:
7611:
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1537:
1456:
1407:
1363:
World Health Organization model list of essential medicines: 21st list 2019
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468:
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1618:
1591:
1519:
372:-(2-chloro-6-methylphenyl)-2--2-methyl-4-pyrimidinyl]amino]-5-thiazole
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2853:
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2828:
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2661:
2486:
2334:
1903:"Drug Approval Package: Sprycel (Dasatinib) NDA #021986 & 022072"
1197:
1079:
916:
908:
825:
403:
339:
66:
1204:. Administration of dasatinib along with quercetin to mice improved
7787:
7782:
7777:
7606:
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7350:
7282:
7247:
7182:
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7075:
6992:
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2425:
2421:
2346:
2150:
Paez-Ribes M, González-Gualda E, Doherty GJ, Muñoz-Espín D (2019).
1192:
Dasatinib has been shown to induce apoptosis in senescent cells by
1075:
1047:
1000:
944:
940:
928:
812:, rash, and diarrhea. Severe adverse effects may include bleeding,
517:
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125:
5474:
5443:
5412:
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686:
7757:
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2519:
2007:
This article incorporates text from this source, which is in the
1958:
This article incorporates text from this source, which is in the
1584:
This article incorporates text from this source, which is in the
1559:"Sprycel (dasatinib) and risk of pulmonary arterial hypertension"
1307:
This article incorporates text from this source, which is in the
964:
837:
7732:
7667:
7312:
6481:
6145:
6034:
5959:
5664:
5659:
5083:
5078:
5032:
5028:
5024:
5020:
5016:
5012:
5008:
4660:
4199:
3877:
1693:
1201:
1096:
Discovery and development of Bcr-Abl tyrosine kinase inhibitors
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548:
345:
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112:
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6513:
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4513:
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972:
968:
809:
677:
528:
319:
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4590:
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4493:
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4297:
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3514:
3300:
2798:
2524:
2506:
2496:
2456:
2324:
956:
508:
1357:
1982:"FDA approves dasatinib for pediatric patients with CML"
1752:"Response and Resistance to BCR-ABL1-Targeted Therapies"
1649:
1375:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
1007:
which returned to normal without dose adjustments. Mild
1164:
dasatinib is available under the trade name Dasanix by
849:
World Health Organization's List of Essential Medicines
781:(ALL). Specifically it is used to treat cases that are
709:
Cc1cccc(c1NC(=O)c2cnc(s2)Nc3cc(nc(n3)C)N4CCN(CC4)CCO)Cl
6584:
Pituitary adenylate cyclase-activating peptide (PACAP)
1694:
Piscitani L, Sirolli V, Morroni M, Bonomini M (2020).
7798:
3716:
2205:
2152:"Targeting senescent cells in translational medicine"
1600:
1603:"Dasatinib-induced pulmonary arterial hypertension"
1502:"Dasatinib-induced pulmonary arterial hypertension"
1431:"Dasatinib: a new step in molecular target therapy"
1339:. The American Society of Health-System Pharmacists
874:In the EU dasatinib is indicated for children with
436:
6530:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5388:Glial cell line-derived neurotrophic factor (GDNF)
5041:Cleavage products/derivatives with unknown target:
1976:
1974:
1972:
1970:
1968:
7822:
6564:Macrophage-stimulating protein (MSP; HLP, HGFLP)
2098:"Senolytic drugs: from discovery to translation"
2095:
1428:
416:
4205:Heparin-binding EGF-like growth factor (HB-EGF)
3888:Heparin-binding EGF-like growth factor (HB-EGF)
2145:
2143:
2091:
2089:
2087:
1965:
1749:
1745:
1743:
1689:
1687:
391:
1553:
1551:
1549:
1547:
1499:
1277:
1275:
1273:
1271:
1269:
1267:
1265:
1263:
1261:
1259:
1003:. A small number of people developed abnormal
142:
7881:World Health Organization essential medicines
6646:
6616:Additional growth factor receptor modulators:
3702:
2271:
969:swelling in the legs and arms and in the face
4970:Insulin-like growth factor-2 (somatomedin A)
4852:Insulin-like growth factor-2 (somatomedin A)
4842:Insulin-like growth factor-1 (somatomedin C)
2140:
2084:
1869:"How Jagabandhu Das made dasatinib possible"
1740:
1684:
1643:
1100:Dasatinib was developed by collaboration of
129:
2021:
2019:
2017:
1701:International Journal of Molecular Sciences
1544:
1493:
1422:
1256:
288:In general: ℞ (Prescription only)
6653:
6639:
3709:
3695:
2278:
2264:
1331:
1329:
1327:
1325:
1323:
1321:
1319:
1317:
773:medication used to treat certain cases of
610:
587:
476:
2177:
2123:
1860:
1777:
1723:
1713:
1667:
1626:
1527:
1446:
1370:
496:
6574:Migration-stimulating factor (MSF; PRG4)
2014:
1607:British Journal of Clinical Pharmacology
1601:Özgür Yurttaş N, Eşkazan AE (May 2018).
1507:British Journal of Clinical Pharmacology
1211:A study of fourteen human patients with
1054:Dasatinib is an ATP-competitive protein
1037:
828:may result in harm to the baby. It is a
7851:Non-receptor tyrosine kinase inhibitors
7841:Drugs developed by Bristol Myers Squibb
3903:Transforming growth factor alpha (TGFα)
1385:
1314:
1050:(blue) in complex with dasatinib (red).
859:Dasatinib is used to treat people with
583:
456:
85:
7823:
6477:Connective tissue growth factor (CTGF)
1351:
1187:
1176:Dasatinib has been shown to eliminate
1112:
601:
280:
255:
103:
6634:
6540:Hepatoma-derived growth factor (HDGF)
3690:
2259:
2025:
1866:
1750:Braun TP, Eide CA, Druker BJ (2020).
1365:. Geneva: World Health Organization.
556:
536:
268:
137:
120:
71:
7499:(piperazine attached via side chain)
2251:. U.S. National Library of Medicine.
1429:Olivieri A, Manzione L (June 2007).
1200:inhibits the anti-apoptotic protein
1058:. The main targets of dasatinib are
215:
516:
407:
13:
2198:
902:
832:and works by blocking a number of
14:
7892:
2237:
2207:activity in preclinical assays".
1062:(the "Philadelphia chromosome"),
907:The most common side effects are
242:
169:
7808:
6559:Leukemia inhibitory factor (LIF)
2096:Kirkland JL, Tchkonia T (2020).
2002:
1953:
1579:
1302:
1241:Therapeutic Goods Administration
1082:. Although dasatinib only has a
644:
641:
635:
38:
29:
6660:
5727:Negative allosteric modulators:
2062:
1925:
1895:
1877:Chemical & Engineering News
1852:(Press release). Archived from
1838:
1822:(Press release). Archived from
1808:
1794:
1500:Yurttaş NO, Eşkazan AE (2018).
1117:
1033:
1013:pulmonary arterial hypertension
854:
734:Key:ZBNZXTGUTAYRHI-UHFFFAOYSA-N
6045:Gossypetin (3,5,7,8,3',4'-HHF)
5236:Platelet-derived growth factor
2209:Journal of Medicinal Chemistry
1463:
1379:
1225:
1155:
1022:On October 11, 2011, the U.S.
913:suppression of the bone marrow
656:
650:
629:
1:
6251:Placental growth factor (PGF)
1669:10.1158/0008-5472.CAN-05-4187
1218:
1213:idiopathic pulmonary fibrosis
785:-positive (Ph+). It is taken
7150:(benzhydrylalkylpiperazines)
6535:Glia maturation factor (GMF)
5044:Glypromate (GPE, (1-3)IGF-1)
2103:Journal of Internal Medicine
1988:Food and Drug Administration
1939:Food and Drug Administration
1909:Food and Drug Administration
1565:Food and Drug Administration
1139:
1024:Food and Drug Administration
865:acute lymphoblastic leukemia
779:acute lymphoblastic leukemia
775:chronic myelogenous leukemia
765:, sold under the brand name
7:
1867:Drahl C (16 January 2012).
1770:10.1016/j.ccell.2020.03.006
1171:
10:
7897:
6467:Colony-stimulating factors
6459:Additional growth factors:
2781:Tyrosine kinase inhibitors
1182:adipocyte progenitor cells
1093:
1089:
935:(fluid around the lungs),
619:Chemical and physical data
7655:
7493:
7452:
7409:
7326:
7144:
7026:
6713:
6668:
6451:
6238:
6133:
5902:
5815:SNA-120 (pegylated K252a)
5642:
5633:
5613:
5527:
5504:
5473:
5442:
5411:
5375:
5366:
5218:
5061:
4994:
4987:(against IGF-1 and IGF-2)
4956:
4949:(against IGF-1 and IGF-2)
4823:
4814:
4632:
4609:
4549:
4468:
4335:
4252:
4243:
4182:
4128:
4041:
3845:
3836:
3805:
3727:
3371:
3148:
2789:
2779:
2647:Mirvetuximab soravtansine
2539:
2420:
2380:
2315:
2302:
1400:10.1007/s40265-016-0677-x
1359:World Health Organization
1288:European Medicines Agency
1056:tyrosine kinase inhibitor
931:, hemorrhage (bleeding),
867:who are positive for the
830:tyrosine-kinase inhibitor
742:
717:
697:
675:
662:
623:
618:
599:
567:
547:
527:
507:
487:
467:
447:
427:
402:
382:
357:
352:
338:
325:
313:
303:
295:
232:
227:
202:
183:
157:
93:
79:
61:
51:
46:
37:
28:
7228:Diphenylmethylpiperazine
7146:Diphenylalkylpiperazines
7041:3-Methylbenzylpiperazine
4651:Hepatocyte growth factor
4210:Neuregulins (heregulins)
4141:Neuregulins (heregulins)
4085:Trastuzumab duocarmazine
3798:(against angiopoietin 2)
3792:(against angiopoietin 3)
2791:Receptor tyrosine kinase
2317:Receptor tyrosine kinase
939:(difficulty breathing),
861:chronic myeloid leukemia
3998:Depatuxizumab mafodotin
2381:Others for solid tumors
2287:Targeted cancer therapy
2249:Drug Information Portal
2170:10.15252/emmm.201810234
2157:EMBO Molecular Medicine
1471:"NHS - Healthcare News"
915:(decreasing numbers of
869:Philadelphia chromosome
783:Philadelphia chromosome
374:carboxamide monohydrate
7328:Pyrimidinylpiperazines
6621:(neurotrophin mixture)
6609:Wnt signaling proteins
6290:Allosteric modulators:
6010:Norwogonin (5,7,8-THF)
4230:5 (tomoregulin, TMEFF)
4080:Trastuzumab deruxtecan
3718:Growth factor receptor
2642:Loncastuximab tesirine
2371:Trastuzumab deruxtecan
1441:(Suppl 6): vi42–vi46.
1166:Beacon Pharmaceuticals
1051:
1028:pulmonary hypertension
7861:Otsuka Pharmaceutical
7371:Pyrimidinylpiperazine
6672:(no additional rings)
6549:T-cell growth factors
4806:Telisotuzumab vedotin
4090:Trastuzumab emtansine
2717:Sacituzumab govitecan
2657:Moxetumomab pasudotox
2627:Inotuzumab ozogamicin
2530:Gemtuzumab ozogamicin
2366:Trastuzumab emtansine
2307:monoclonal antibodies
2291:antineoplastic agents
1613:(5). Wiley: 835–845.
1448:10.1093/annonc/mdm223
1233:"Sprycel (Dasatinib)"
1194:inhibiting Src kinase
1041:
822:prolonged QT syndrome
798:low white blood cells
7703:Cyclohexylpiperazine
7656:Others/Uncategorized
7411:Pyridinylpiperazines
6680:Aminoethylpiperazine
5134:EVT-901 (SAR-127963)
4867:Mecasermin rinfabate
2572:Belantamab mafodotin
1933:"2010 Notifications"
1873:The Safety Zone blog
1850:Bristol-Myers Squibb
1826:on 20 September 2018
1820:Bristol-Myers Squibb
1715:10.3390/ijms21144878
1102:Bristol-Myers Squibb
1005:liver function tests
961:musculoskeletal pain
7454:Benzo(iso)thiazolyl
7444:Pyridinylpiperazine
3425:Denileukin diftitox
3087:(ALK, ROS1, NTRK),
2692:Polatuzumab vedotin
2682:Oportuzumab monatox
1883:on 10 December 2017
1856:on 31 January 2015.
1569:. 23 September 2011
1292:. 17 September 2018
1188:Dasatinib+Quercetin
1113:Society and culture
1042:Crystal structure (
802:low blood platelets
769:among others, is a
264:(Prescription only)
251:(Prescription only)
25:
6898:Naphthylpiperazine
6788:Diphenylpiperazine
6685:Diethylcarbamazine
6669:Simple piperazines
6300:Kinase inhibitors:
6163:Kinase inhibitors:
6062:Kinase inhibitors:
5737:Kinase inhibitors:
5552:Kinase inhibitors:
5512:Kinase inhibitors:
5493:Kinase inhibitors:
5462:Kinase inhibitors:
5431:Kinase inhibitors:
5400:Kinase inhibitors:
5260:Kinase inhibitors:
4874:Kinase inhibitors:
4668:Kinase inhibitors:
4457:Kinase inhibitors:
4450:Aprutumab ixadotin
4097:Kinase inhibitors:
3910:Kinase inhibitors:
3767:Kinase inhibitors:
3111:(ROS1, TRK, ALK),
2617:Enfortumab vedotin
2116:10.1111/joim.13141
1943:. 18 November 2010
1913:. 6 September 2006
1435:Annals of Oncology
1107:medicinal chemists
1052:
21:
7796:
7795:
7500:
7151:
7101:Methoxypiperamide
7028:Benzylpiperazines
6715:Phenylpiperazines
6673:
6628:
6627:
6234:
6233:
5995:N-Acetylserotonin
5894:ReN-1820 (TrkAd5)
5523:
5522:
5057:
5056:
5002:Binding proteins:
4661:Dihexa (PNB-0408)
4628:
4627:
4239:
4238:
4153:6 (neuroglycan C)
3873:EGF (urogastrone)
3851:
3684:
3683:
3367:
3366:
2775:
2774:
2757:Tisotumab vedotin
2221:10.1021/jm049486a
2040:10.1136/bmj.g6593
1992:. 9 November 2017
1619:10.1111/bcp.13508
1520:10.1111/bcp.13508
1134:body surface area
1048:Abl kinase domain
985:pleural effusions
842:Src kinase family
760:
759:
688:Interactive image
569:CompTox Dashboard
284:
272:
259:
246:
173:
140:
123:
106:
16:Chemical compound
7888:
7871:Primary alcohols
7831:Aminopyrimidines
7813:
7812:
7811:
7804:
7663:6-Nitroquipazine
7627:Thiethylperazine
7622:Prochlorperazine
7498:
7193:Chlorbenzoxamine
7149:
7066:Chlorbenzoxamine
6858:Levodropropizine
6671:
6655:
6648:
6641:
6632:
6631:
6440:Decoy receptors:
6413:Alacizumab pegol
5891:Decoy receptors:
5640:
5639:
5545:Stem cell factor
5486:Persephin (PSPN)
5424:Neurturin (NRTN)
5373:
5372:
5210:LEVI-04 (p75-Fc)
5207:Decoy receptors:
4821:
4820:
4250:
4249:
3849:
3843:
3842:
3711:
3704:
3697:
3688:
3687:
3398:peptide against
2971:(AXL, ALK, LTK))
2787:
2786:
2597:Dinutuximab beta
2313:
2312:
2280:
2273:
2266:
2257:
2256:
2252:
2232:
2192:
2191:
2181:
2147:
2138:
2137:
2127:
2093:
2082:
2081:
2079:
2077:
2066:
2060:
2059:
2023:
2012:
2006:
2005:
2001:
1999:
1997:
1978:
1963:
1957:
1956:
1952:
1950:
1948:
1929:
1923:
1922:
1920:
1918:
1899:
1893:
1892:
1890:
1888:
1879:. Archived from
1864:
1858:
1857:
1842:
1836:
1835:
1833:
1831:
1812:
1806:
1805:
1804:. 17 April 2023.
1798:
1792:
1791:
1781:
1747:
1738:
1737:
1727:
1717:
1691:
1682:
1681:
1671:
1647:
1641:
1640:
1630:
1598:
1589:
1583:
1582:
1578:
1576:
1574:
1555:
1542:
1541:
1531:
1497:
1491:
1490:
1488:
1486:
1477:. Archived from
1467:
1461:
1460:
1450:
1426:
1420:
1419:
1383:
1377:
1376:
1374:
1355:
1349:
1348:
1346:
1344:
1333:
1312:
1306:
1305:
1301:
1299:
1297:
1279:
1254:
1253:
1251:
1249:
1237:
1229:
1084:plasma half-life
1072:ephrin receptors
1017:endothelial cell
981:myelosuppression
951:(feeling sick),
933:pleural effusion
888:and adults with
863:and people with
834:tyrosine kinases
771:targeted therapy
756:
755:
748:
690:
670:
658:
652:
646:
643:
637:
631:
614:
603:
592:
591:
577:
575:
560:
540:
520:
500:
480:
460:
440:
420:
410:
409:
395:
330:
282:
279:
270:
267:
257:
254:
244:
241:
219:
171:
168:
150:
139:
136:
133:
122:
119:
116:
105:
102:
89:
75:
57:Sprycel, Dasanix
42:
33:
26:
24:
20:
7896:
7895:
7891:
7890:
7889:
7887:
7886:
7885:
7821:
7820:
7819:
7809:
7807:
7799:
7797:
7792:
7651:
7637:Trifluoperazine
7572:Octomethothepin
7497:
7489:
7448:
7405:
7322:
7148:
7140:
7022:
6709:
6670:
6664:
6659:
6629:
6624:
6569:Midkine (NEGF2)
6447:
6230:
6129:
5898:
5836:ABT-110 (PG110)
5629:
5609:
5519:
5500:
5469:
5438:
5407:
5362:
5214:
5152:ABT-110 (PG110)
5053:
4990:
4952:
4810:
4624:
4605:
4545:
4542:(against FGF23)
4464:
4331:
4235:
4178:
4124:
4037:
3848:
3832:
3801:
3723:
3715:
3685:
3680:
3534:Pi3K inhibitors
3432:mTOR inhibitors
3363:
3144:
3115:(VEGFR, FGFR),
2771:
2535:
2416:
2376:
2298:
2284:
2243:
2240:
2235:
2215:(27): 6658–61.
2201:
2199:Further reading
2196:
2195:
2148:
2141:
2094:
2085:
2075:
2073:
2068:
2067:
2063:
2024:
2015:
2003:
1995:
1993:
1980:
1979:
1966:
1954:
1946:
1944:
1931:
1930:
1926:
1916:
1914:
1901:
1900:
1896:
1886:
1884:
1865:
1861:
1844:
1843:
1839:
1829:
1827:
1814:
1813:
1809:
1800:
1799:
1795:
1748:
1741:
1692:
1685:
1656:Cancer Research
1648:
1644:
1599:
1592:
1580:
1572:
1570:
1557:
1556:
1545:
1498:
1494:
1484:
1482:
1469:
1468:
1464:
1427:
1423:
1384:
1380:
1356:
1352:
1342:
1340:
1335:
1334:
1315:
1303:
1295:
1293:
1281:
1280:
1257:
1247:
1245:
1235:
1231:
1230:
1226:
1221:
1190:
1178:senescent cells
1174:
1158:
1142:
1120:
1115:
1098:
1092:
1036:
905:
903:Adverse effects
857:
814:pulmonary edema
794:adverse effects
751:
749:
746:(what is this?)
743:
738:
735:
730:
725:
724:
713:
710:
705:
704:
693:
668:
655:
649:
640:
634:
595:
571:
563:
543:
523:
503:
483:
463:
443:
423:
406:
398:
378:
375:
373:
365:
364:
328:
305:Protein binding
297:Pharmacokinetic
291:
223:
186:
179:
160:
153:
17:
12:
11:
5:
7894:
7884:
7883:
7878:
7873:
7868:
7863:
7858:
7853:
7848:
7843:
7838:
7833:
7818:
7817:
7794:
7793:
7791:
7790:
7785:
7780:
7775:
7770:
7765:
7760:
7755:
7750:
7745:
7740:
7735:
7730:
7725:
7720:
7715:
7710:
7705:
7700:
7695:
7690:
7688:Cinepazic acid
7685:
7680:
7675:
7670:
7665:
7659:
7657:
7653:
7652:
7650:
7649:
7647:Zuclopenthixol
7644:
7639:
7634:
7629:
7624:
7619:
7614:
7609:
7604:
7599:
7594:
7589:
7584:
7579:
7574:
7569:
7564:
7559:
7554:
7552:Isofloxythepin
7549:
7544:
7539:
7534:
7529:
7524:
7519:
7514:
7509:
7503:
7501:
7491:
7490:
7488:
7487:
7482:
7477:
7472:
7467:
7461:
7459:
7450:
7449:
7447:
7446:
7441:
7436:
7431:
7426:
7421:
7415:
7413:
7407:
7406:
7404:
7403:
7398:
7393:
7388:
7383:
7378:
7373:
7368:
7363:
7358:
7353:
7348:
7343:
7338:
7332:
7330:
7324:
7323:
7321:
7320:
7315:
7310:
7305:
7300:
7295:
7290:
7285:
7280:
7275:
7270:
7265:
7260:
7255:
7250:
7245:
7240:
7235:
7230:
7225:
7220:
7215:
7210:
7205:
7200:
7198:Chlorcyclizine
7195:
7190:
7185:
7180:
7175:
7170:
7165:
7160:
7154:
7152:
7142:
7141:
7139:
7138:
7133:
7128:
7123:
7118:
7113:
7108:
7103:
7098:
7093:
7088:
7083:
7078:
7073:
7068:
7063:
7058:
7053:
7048:
7043:
7038:
7032:
7030:
7024:
7023:
7021:
7020:
7015:
7010:
7005:
7000:
6995:
6990:
6985:
6980:
6975:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6915:
6910:
6905:
6900:
6895:
6890:
6885:
6880:
6875:
6870:
6865:
6860:
6855:
6850:
6845:
6840:
6835:
6830:
6825:
6820:
6815:
6810:
6805:
6800:
6795:
6790:
6785:
6780:
6775:
6770:
6765:
6760:
6755:
6750:
6745:
6740:
6735:
6730:
6725:
6719:
6717:
6711:
6710:
6708:
6707:
6702:
6697:
6692:
6687:
6682:
6676:
6674:
6666:
6665:
6658:
6657:
6650:
6643:
6635:
6626:
6625:
6623:
6622:
6612:
6611:
6606:
6599:Thrombopoietin
6596:
6591:
6586:
6581:
6576:
6571:
6566:
6561:
6556:
6542:
6537:
6532:
6527:
6520:Erythropoietin
6517:
6479:
6474:
6464:
6462:Adrenomedullin
6455:
6453:
6449:
6448:
6446:
6445:
6436:
6435:
6430:
6425:
6420:
6415:
6406:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6360:
6355:
6350:
6345:
6340:
6335:
6330:
6325:
6320:
6315:
6310:
6305:
6296:
6295:
6286:
6285:
6263:
6258:
6253:
6244:
6242:
6236:
6235:
6232:
6231:
6229:
6228:
6223:
6218:
6213:
6208:
6203:
6198:
6193:
6188:
6183:
6178:
6173:
6168:
6159:
6158:
6153:
6148:
6139:
6137:
6131:
6130:
6128:
6127:
6122:
6117:
6112:
6107:
6102:
6097:
6092:
6087:
6082:
6077:
6072:
6067:
6058:
6057:
6048:
6047:
6042:
6037:
6028:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5977:
5972:
5967:
5962:
5957:
5952:
5947:
5942:
5937:
5932:
5927:
5925:4'-DMA-7,8-DHF
5922:
5917:
5908:
5906:
5900:
5899:
5897:
5896:
5887:
5886:
5874:
5873:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5819:
5818:
5812:
5807:
5802:
5797:
5792:
5787:
5782:
5777:
5772:
5767:
5762:
5757:
5752:
5747:
5742:
5733:
5732:
5723:
5722:
5717:
5712:
5707:
5698:
5697:
5692:
5687:
5685:Gambogic amide
5682:
5677:
5672:
5667:
5662:
5657:
5648:
5646:
5637:
5631:
5630:
5628:
5627:
5619:
5617:
5611:
5610:
5608:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5548:
5547:
5542:
5533:
5531:
5525:
5524:
5521:
5520:
5518:
5517:
5508:
5506:
5502:
5501:
5499:
5498:
5489:
5488:
5479:
5477:
5471:
5470:
5468:
5467:
5458:
5457:
5455:Artemin (ARTN)
5448:
5446:
5440:
5439:
5437:
5436:
5427:
5426:
5417:
5415:
5409:
5408:
5406:
5405:
5396:
5395:
5390:
5381:
5379:
5370:
5364:
5363:
5361:
5360:
5355:
5350:
5341:
5340:
5335:
5330:
5325:
5320:
5315:
5310:
5305:
5300:
5295:
5290:
5285:
5280:
5275:
5270:
5265:
5256:
5255:
5233:
5224:
5222:
5216:
5215:
5213:
5212:
5203:
5202:
5190:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5142:
5141:
5136:
5131:
5126:
5117:
5116:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5067:
5065:
5059:
5058:
5055:
5054:
5052:
5051:
5046:
5037:
5036:
4998:
4996:
4992:
4991:
4989:
4988:
4982:
4973:
4972:
4962:
4960:
4954:
4953:
4951:
4950:
4944:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4900:
4899:
4894:
4889:
4884:
4879:
4870:
4869:
4864:
4859:
4854:
4849:
4844:
4839:
4829:
4827:
4818:
4812:
4811:
4809:
4808:
4803:
4798:
4793:
4788:
4783:
4778:
4769:
4768:
4763:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4664:
4663:
4654:
4653:
4648:
4638:
4636:
4630:
4629:
4626:
4625:
4623:
4622:
4613:
4611:
4607:
4606:
4604:
4603:
4598:
4564:
4555:
4553:
4547:
4546:
4544:
4543:
4533:
4532:
4527:
4522:
4517:
4483:
4474:
4472:
4466:
4465:
4463:
4462:
4453:
4452:
4447:
4438:
4437:
4432:
4427:
4422:
4417:
4412:
4350:
4341:
4339:
4333:
4332:
4330:
4329:
4324:
4319:
4314:
4309:
4267:
4258:
4256:
4247:
4241:
4240:
4237:
4236:
4234:
4233:
4207:
4202:
4197:
4188:
4186:
4180:
4179:
4177:
4176:
4171:
4166:
4157:
4156:
4134:
4132:
4126:
4125:
4123:
4122:
4117:
4112:
4107:
4102:
4093:
4092:
4087:
4082:
4077:
4072:
4067:
4058:
4057:
4047:
4045:
4039:
4038:
4036:
4035:
4030:
4025:
4020:
4015:
4010:
4005:
4000:
3995:
3990:
3981:
3980:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3930:
3925:
3920:
3915:
3906:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3855:
3853:
3840:
3834:
3833:
3831:
3830:
3825:
3820:
3811:
3809:
3803:
3802:
3800:
3799:
3793:
3783:
3782:
3777:
3772:
3763:
3762:
3760:Angiopoietin 3
3757:
3755:Angiopoietin 2
3748:
3747:
3745:Angiopoietin 4
3742:
3740:Angiopoietin 1
3733:
3731:
3725:
3724:
3714:
3713:
3706:
3699:
3691:
3682:
3681:
3679:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3563:
3562:
3561:
3556:
3551:
3546:
3541:
3531:
3530:
3529:
3524:
3511:
3510:
3509:
3504:
3499:
3494:
3489:
3481:CDK inhibitors
3477:
3476:
3475:
3470:
3465:
3452:
3451:
3450:
3445:
3440:
3428:
3412:
3392:
3380:fusion protein
3375:
3373:
3369:
3368:
3365:
3364:
3362:
3361:
3360:
3359:
3354:
3349:
3344:
3339:
3326:
3325:
3324:
3323:
3318:
3313:
3296:
3295:
3294:
3293:
3288:
3283:
3278:
3265:
3264:
3263:
3262:
3257:
3252:
3247:
3242:
3237:
3232:
3219:
3218:
3212:
3200:
3199:
3198:
3197:
3192:
3187:
3182:
3177:
3172:
3167:
3154:
3152:
3146:
3145:
3143:
3142:
3121:
3120:
3119:(VEGFR, EGFR).
3075:
3074:
3073:
3072:
3067:
3062:
3049:
3048:
3047:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2973:
2972:
2956:
2950:
2945:
2940:
2935:
2930:
2925:
2920:
2900:
2899:
2898:
2897:
2892:
2887:
2877:HER1/EGFR and
2873:
2872:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2795:
2793:
2784:
2777:
2776:
2773:
2772:
2770:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2556:+hyaluronidase
2549:
2543:
2541:
2537:
2536:
2534:
2533:
2516:
2515:
2489:
2484:
2479:
2474:
2469:
2464:
2430:
2428:
2418:
2417:
2415:
2414:
2402:
2396:
2384:
2382:
2378:
2377:
2375:
2374:
2368:
2363:
2360:+hyaluronidase
2343:
2337:
2321:
2319:
2310:
2300:
2299:
2283:
2282:
2275:
2268:
2260:
2254:
2253:
2239:
2238:External links
2236:
2234:
2233:
2202:
2200:
2197:
2194:
2193:
2164:(12): e10234.
2139:
2110:(5): 518–536.
2083:
2061:
2013:
1964:
1924:
1894:
1859:
1837:
1807:
1793:
1764:(4): 530–542.
1739:
1683:
1662:(11): 5790–7.
1642:
1590:
1543:
1514:(5): 835–845.
1492:
1462:
1421:
1378:
1350:
1313:
1283:"Sprycel EPAR"
1255:
1223:
1222:
1220:
1217:
1206:cardiovascular
1189:
1186:
1173:
1170:
1157:
1154:
1141:
1138:
1119:
1116:
1114:
1111:
1091:
1088:
1035:
1032:
955:(belly ache),
953:abdominal pain
904:
901:
900:
899:
896:
893:
886:
885:
882:
879:
856:
853:
758:
757:
740:
739:
737:
736:
733:
731:
728:
720:
719:
718:
715:
714:
712:
711:
708:
700:
699:
698:
695:
694:
692:
691:
683:
681:
673:
672:
666:
660:
659:
653:
647:
638:
632:
627:
621:
620:
616:
615:
605:
597:
596:
594:
593:
580:
578:
565:
564:
562:
561:
553:
551:
545:
544:
542:
541:
533:
531:
525:
524:
522:
521:
513:
511:
505:
504:
502:
501:
493:
491:
485:
484:
482:
481:
473:
471:
465:
464:
462:
461:
453:
451:
445:
444:
442:
441:
433:
431:
425:
424:
422:
421:
413:
411:
400:
399:
397:
396:
388:
386:
380:
379:
377:
376:
368:
360:
359:
358:
355:
354:
350:
349:
342:
336:
335:
334:1.3 to 5 hours
332:
323:
322:
317:
311:
310:
307:
301:
300:
293:
292:
290:
289:
286:
277:
265:
252:
238:
236:
230:
229:
225:
224:
222:
221:
208:
206:
200:
199:
189:
187:administration
181:
180:
178:
177:
175:
165:
163:
155:
154:
152:
151:
134:
117:
99:
97:
91:
90:
83:
77:
76:
69:
59:
58:
55:
49:
48:
44:
43:
35:
34:
15:
9:
6:
4:
3:
2:
7893:
7882:
7879:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7847:
7844:
7842:
7839:
7837:
7834:
7832:
7829:
7828:
7826:
7816:
7806:
7805:
7802:
7789:
7786:
7784:
7781:
7779:
7776:
7774:
7771:
7769:
7766:
7764:
7761:
7759:
7756:
7754:
7751:
7749:
7746:
7744:
7741:
7739:
7736:
7734:
7731:
7729:
7726:
7724:
7721:
7719:
7716:
7714:
7711:
7709:
7706:
7704:
7701:
7699:
7696:
7694:
7691:
7689:
7686:
7684:
7681:
7679:
7676:
7674:
7671:
7669:
7666:
7664:
7661:
7660:
7658:
7654:
7648:
7645:
7643:
7640:
7638:
7635:
7633:
7630:
7628:
7625:
7623:
7620:
7618:
7615:
7613:
7610:
7608:
7605:
7603:
7600:
7598:
7597:Peradithiepin
7595:
7593:
7590:
7588:
7585:
7583:
7580:
7578:
7575:
7573:
7570:
7568:
7565:
7563:
7562:Meperathiepin
7560:
7558:
7555:
7553:
7550:
7548:
7545:
7543:
7540:
7538:
7537:Docloxythepin
7535:
7533:
7530:
7528:
7525:
7523:
7520:
7518:
7515:
7513:
7510:
7508:
7505:
7504:
7502:
7496:
7492:
7486:
7483:
7481:
7478:
7476:
7473:
7471:
7468:
7466:
7463:
7462:
7460:
7458:
7455:
7451:
7445:
7442:
7440:
7437:
7435:
7432:
7430:
7427:
7425:
7422:
7420:
7417:
7416:
7414:
7412:
7408:
7402:
7399:
7397:
7394:
7392:
7389:
7387:
7384:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7349:
7347:
7344:
7342:
7339:
7337:
7334:
7333:
7331:
7329:
7325:
7319:
7316:
7314:
7311:
7309:
7306:
7304:
7301:
7299:
7296:
7294:
7291:
7289:
7286:
7284:
7281:
7279:
7276:
7274:
7271:
7269:
7266:
7264:
7261:
7259:
7256:
7254:
7251:
7249:
7246:
7244:
7241:
7239:
7236:
7234:
7231:
7229:
7226:
7224:
7223:Diphenpipenol
7221:
7219:
7216:
7214:
7211:
7209:
7206:
7204:
7201:
7199:
7196:
7194:
7191:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7166:
7164:
7161:
7159:
7156:
7155:
7153:
7147:
7143:
7137:
7134:
7132:
7131:Trimetazidine
7129:
7127:
7124:
7122:
7119:
7117:
7114:
7112:
7109:
7107:
7104:
7102:
7099:
7097:
7094:
7092:
7089:
7087:
7084:
7082:
7079:
7077:
7074:
7072:
7069:
7067:
7064:
7062:
7059:
7057:
7054:
7052:
7049:
7047:
7044:
7042:
7039:
7037:
7034:
7033:
7031:
7029:
7025:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6994:
6991:
6989:
6986:
6984:
6981:
6979:
6976:
6974:
6973:Sonepiprazole
6971:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6836:
6834:
6831:
6829:
6826:
6824:
6821:
6819:
6816:
6814:
6811:
6809:
6806:
6804:
6801:
6799:
6796:
6794:
6791:
6789:
6786:
6784:
6781:
6779:
6776:
6774:
6771:
6769:
6766:
6764:
6763:Ciprofloxacin
6761:
6759:
6756:
6754:
6751:
6749:
6746:
6744:
6741:
6739:
6736:
6734:
6731:
6729:
6726:
6724:
6721:
6720:
6718:
6716:
6712:
6706:
6703:
6701:
6698:
6696:
6693:
6691:
6688:
6686:
6683:
6681:
6678:
6677:
6675:
6667:
6663:
6656:
6651:
6649:
6644:
6642:
6637:
6636:
6633:
6620:
6617:
6614:
6613:
6610:
6607:
6604:
6600:
6597:
6595:
6592:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6565:
6562:
6560:
6557:
6554:
6550:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6525:
6521:
6518:
6515:
6511:
6507:
6503:
6499:
6495:
6491:
6487:
6483:
6480:
6478:
6475:
6472:
6468:
6465:
6463:
6460:
6457:
6456:
6454:
6450:
6444:
6441:
6438:
6437:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6416:
6414:
6411:
6408:
6407:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6351:
6349:
6346:
6344:
6341:
6339:
6336:
6334:
6331:
6329:
6326:
6324:
6321:
6319:
6316:
6314:
6311:
6309:
6306:
6304:
6301:
6298:
6297:
6294:
6293:Cyclotraxin B
6291:
6288:
6287:
6283:
6279:
6275:
6271:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6246:
6245:
6243:
6241:
6237:
6227:
6224:
6222:
6219:
6217:
6214:
6212:
6209:
6207:
6206:Larotrectinib
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6174:
6172:
6169:
6167:
6164:
6161:
6160:
6157:
6154:
6152:
6149:
6147:
6144:
6141:
6140:
6138:
6136:
6132:
6126:
6123:
6121:
6118:
6116:
6113:
6111:
6108:
6106:
6105:Larotrectinib
6103:
6101:
6098:
6096:
6093:
6091:
6088:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6060:
6059:
6056:
6053:
6050:
6049:
6046:
6043:
6041:
6040:Cyclotraxin B
6038:
6036:
6033:
6030:
6029:
6026:
6023:
6021:
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5976:
5973:
5971:
5968:
5966:
5963:
5961:
5958:
5956:
5953:
5951:
5950:Amitriptyline
5948:
5946:
5943:
5941:
5938:
5936:
5933:
5931:
5928:
5926:
5923:
5921:
5918:
5916:
5913:
5910:
5909:
5907:
5905:
5901:
5895:
5892:
5889:
5888:
5885:
5882:
5879:
5876:
5875:
5872:
5869:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5830:
5827:
5826:Against TrkA:
5824:
5821:
5820:
5816:
5813:
5811:
5808:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5780:Larotrectinib
5778:
5776:
5773:
5771:
5768:
5766:
5763:
5761:
5758:
5756:
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5735:
5734:
5731:
5728:
5725:
5724:
5721:
5718:
5716:
5713:
5711:
5710:Dexamethasone
5708:
5706:
5703:
5700:
5699:
5696:
5693:
5691:
5688:
5686:
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5655:Amitriptyline
5653:
5650:
5649:
5647:
5645:
5641:
5638:
5636:
5632:
5625:
5621:
5620:
5618:
5616:
5612:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5550:
5549:
5546:
5543:
5541:
5538:
5535:
5534:
5532:
5530:
5526:
5516:
5513:
5510:
5509:
5507:
5503:
5497:
5494:
5491:
5490:
5487:
5484:
5481:
5480:
5478:
5476:
5472:
5466:
5463:
5460:
5459:
5456:
5453:
5450:
5449:
5447:
5445:
5441:
5435:
5432:
5429:
5428:
5425:
5422:
5419:
5418:
5416:
5414:
5410:
5404:
5401:
5398:
5397:
5394:
5391:
5389:
5386:
5383:
5382:
5380:
5378:
5374:
5371:
5369:
5365:
5359:
5356:
5354:
5351:
5349:
5346:
5343:
5342:
5339:
5336:
5334:
5331:
5329:
5326:
5324:
5321:
5319:
5316:
5314:
5311:
5309:
5306:
5304:
5301:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5279:
5276:
5274:
5271:
5269:
5266:
5264:
5261:
5258:
5257:
5253:
5249:
5245:
5241:
5237:
5234:
5232:
5229:
5226:
5225:
5223:
5221:
5217:
5211:
5208:
5205:
5204:
5201:
5198:
5195:
5192:
5191:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5147:
5144:
5143:
5140:
5137:
5135:
5132:
5130:
5129:Dexamethasone
5127:
5125:
5122:
5119:
5118:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5069:
5068:
5066:
5064:
5060:
5050:
5047:
5045:
5042:
5039:
5038:
5034:
5030:
5026:
5022:
5018:
5014:
5010:
5006:
5003:
5000:
4999:
4997:
4993:
4986:
4983:
4981:
4978:
4975:
4974:
4971:
4967:
4964:
4963:
4961:
4959:
4955:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4902:
4901:
4898:
4895:
4893:
4890:
4888:
4885:
4883:
4880:
4878:
4875:
4872:
4871:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4848:
4845:
4843:
4840:
4838:
4837:des(1-3)IGF-1
4834:
4831:
4830:
4828:
4826:
4822:
4819:
4817:
4813:
4807:
4804:
4802:
4801:Telisotuzumab
4799:
4797:
4794:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4771:
4770:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4717:
4714:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4666:
4665:
4662:
4659:
4658:Potentiators:
4656:
4655:
4652:
4649:
4647:
4643:
4640:
4639:
4637:
4635:
4631:
4621:
4618:
4615:
4614:
4612:
4608:
4602:
4599:
4596:
4592:
4588:
4584:
4580:
4576:
4572:
4568:
4565:
4563:
4560:
4557:
4556:
4554:
4552:
4548:
4541:
4538:
4535:
4534:
4531:
4528:
4526:
4523:
4521:
4520:Selpercatinib
4518:
4515:
4511:
4507:
4503:
4499:
4495:
4491:
4487:
4484:
4482:
4479:
4476:
4475:
4473:
4471:
4467:
4461:
4458:
4455:
4454:
4451:
4448:
4446:
4443:
4440:
4439:
4436:
4433:
4431:
4428:
4426:
4425:Selpercatinib
4423:
4421:
4418:
4416:
4413:
4410:
4406:
4402:
4398:
4394:
4390:
4386:
4382:
4378:
4374:
4370:
4366:
4362:
4358:
4354:
4351:
4349:
4346:
4343:
4342:
4340:
4338:
4334:
4328:
4325:
4323:
4320:
4318:
4317:Selpercatinib
4315:
4313:
4310:
4307:
4303:
4299:
4295:
4291:
4287:
4283:
4279:
4275:
4271:
4268:
4266:
4263:
4260:
4259:
4257:
4255:
4251:
4248:
4246:
4242:
4231:
4227:
4223:
4219:
4215:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4190:
4189:
4187:
4185:
4181:
4175:
4172:
4170:
4167:
4165:
4162:
4159:
4158:
4154:
4150:
4146:
4142:
4139:
4136:
4135:
4133:
4131:
4127:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4095:
4094:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4063:
4060:
4059:
4056:
4052:
4049:
4048:
4046:
4044:
4040:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3993:Depatuxizumab
3991:
3989:
3986:
3983:
3982:
3979:
3976:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3914:
3911:
3908:
3907:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3860:
3857:
3856:
3854:
3852:
3844:
3841:
3839:
3835:
3829:
3826:
3824:
3821:
3819:
3816:
3813:
3812:
3810:
3808:
3804:
3797:
3794:
3791:
3788:
3785:
3784:
3781:
3778:
3776:
3773:
3771:
3768:
3765:
3764:
3761:
3758:
3756:
3753:
3750:
3749:
3746:
3743:
3741:
3738:
3735:
3734:
3732:
3730:
3726:
3722:
3719:
3712:
3707:
3705:
3700:
3698:
3693:
3692:
3689:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3591:Larotrectinib
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3536:
3535:
3532:
3528:
3525:
3523:
3520:
3519:
3518:
3516:
3512:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3484:
3483:
3482:
3478:
3474:
3471:
3469:
3466:
3464:
3461:
3460:
3459:
3457:
3453:
3449:
3446:
3444:
3443:Ridaforolimus
3441:
3439:
3436:
3435:
3434:
3433:
3429:
3426:
3422:
3421:
3417:
3413:
3410:
3406:
3405:
3401:
3397:
3393:
3390:
3386:
3385:
3381:
3377:
3376:
3374:
3370:
3358:
3355:
3353:
3352:Pirtobrutinib
3350:
3348:
3347:Orelabrutinib
3345:
3343:
3340:
3338:
3337:Acalabrutinib
3335:
3334:
3333:
3332:
3328:
3327:
3322:
3319:
3317:
3314:
3312:
3309:
3308:
3307:
3306:
3302:
3298:
3297:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3273:
3272:
3271:
3267:
3266:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3227:
3226:
3225:
3221:
3220:
3216:
3213:
3211:
3207:
3206:
3202:
3201:
3196:
3193:
3191:
3188:
3186:
3183:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3162:
3161:
3160:
3156:
3155:
3153:
3151:
3147:
3140:
3136:
3132:
3129:
3127:
3123:
3122:
3118:
3114:
3113:Selpercatinib
3110:
3109:Repotrectinib
3106:
3102:
3098:
3097:Larotrectinib
3094:
3090:
3086:
3083:
3081:
3077:
3076:
3071:
3068:
3066:
3063:
3061:
3058:
3057:
3056:
3055:
3051:
3050:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2981:
2980:
2979:
2975:
2974:
2970:
2966:
2962:
2961:
2957:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2934:
2931:
2929:
2926:
2924:
2921:
2919:
2915:
2914:
2910:
2905:
2904:RTK class III
2902:
2901:
2896:
2893:
2891:
2888:
2886:
2883:
2882:
2881:
2880:
2875:
2874:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2806:
2805:
2800:
2797:
2796:
2794:
2792:
2788:
2785:
2782:
2778:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2687:Pembrolizumab
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2652:Mogamulizumab
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2557:
2553:
2550:
2548:
2545:
2544:
2542:
2538:
2531:
2527:
2526:
2521:
2518:
2517:
2513:
2509:
2508:
2503:
2499:
2498:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2472:Mosunetuzumab
2470:
2468:
2465:
2463:
2459:
2458:
2453:
2452:Mosunetuzumab
2449:
2445:
2441:
2440:
2435:
2432:
2431:
2429:
2427:
2423:
2419:
2412:
2408:
2407:
2403:
2400:
2397:
2395:
2391:
2390:
2386:
2385:
2383:
2379:
2372:
2369:
2367:
2364:
2361:
2357:
2353:
2349:
2348:
2344:
2341:
2338:
2336:
2332:
2331:
2326:
2323:
2322:
2320:
2318:
2314:
2311:
2308:
2305:
2301:
2296:
2292:
2288:
2281:
2276:
2274:
2269:
2267:
2262:
2261:
2258:
2250:
2246:
2242:
2241:
2230:
2226:
2222:
2218:
2214:
2210:
2204:
2203:
2189:
2185:
2180:
2175:
2171:
2167:
2163:
2159:
2158:
2153:
2146:
2144:
2135:
2131:
2126:
2121:
2117:
2113:
2109:
2105:
2104:
2099:
2092:
2090:
2088:
2071:
2065:
2057:
2053:
2049:
2045:
2041:
2037:
2033:
2029:
2022:
2020:
2018:
2010:
2009:public domain
1991:
1989:
1983:
1977:
1975:
1973:
1971:
1969:
1961:
1960:public domain
1942:
1940:
1934:
1928:
1912:
1910:
1904:
1898:
1882:
1878:
1874:
1870:
1863:
1855:
1851:
1847:
1841:
1825:
1821:
1817:
1811:
1803:
1797:
1789:
1785:
1780:
1775:
1771:
1767:
1763:
1759:
1758:
1753:
1746:
1744:
1735:
1731:
1726:
1721:
1716:
1711:
1708:(14): e4878.
1707:
1703:
1702:
1697:
1690:
1688:
1679:
1675:
1670:
1665:
1661:
1657:
1653:
1646:
1638:
1634:
1629:
1624:
1620:
1616:
1612:
1608:
1604:
1597:
1595:
1587:
1586:public domain
1568:
1566:
1560:
1554:
1552:
1550:
1548:
1539:
1535:
1530:
1525:
1521:
1517:
1513:
1509:
1508:
1503:
1496:
1481:on 5 May 2013
1480:
1476:
1472:
1466:
1458:
1454:
1449:
1444:
1440:
1436:
1432:
1425:
1417:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1382:
1373:
1368:
1364:
1360:
1354:
1338:
1332:
1330:
1328:
1326:
1324:
1322:
1320:
1318:
1310:
1309:public domain
1291:
1289:
1284:
1278:
1276:
1274:
1272:
1270:
1268:
1266:
1264:
1262:
1260:
1244:
1242:
1234:
1228:
1224:
1216:
1214:
1209:
1207:
1203:
1199:
1195:
1185:
1183:
1179:
1169:
1167:
1163:
1153:
1150:
1146:
1137:
1135:
1129:
1126:
1123:
1110:
1108:
1103:
1097:
1087:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1057:
1049:
1045:
1040:
1031:
1029:
1025:
1020:
1018:
1014:
1010:
1006:
1002:
998:
994:
990:
989:thoracentesis
986:
982:
978:
974:
970:
966:
962:
958:
954:
950:
946:
942:
938:
934:
930:
926:
922:
918:
914:
910:
897:
894:
891:
890:
889:
883:
880:
877:
876:
875:
872:
870:
866:
862:
852:
850:
845:
843:
839:
835:
831:
827:
824:. Use during
823:
819:
818:heart failure
815:
811:
807:
803:
799:
795:
790:
788:
784:
780:
776:
772:
768:
764:
754:
747:
741:
732:
727:
726:
723:
716:
707:
706:
703:
696:
689:
685:
684:
682:
679:
674:
667:
665:
661:
628:
626:
622:
617:
613:
609:
606:
604:
602:ECHA InfoCard
598:
590:
586:
585:DTXSID4040979
582:
581:
579:
570:
566:
559:
555:
554:
552:
550:
546:
539:
535:
534:
532:
530:
526:
519:
515:
514:
512:
510:
506:
499:
495:
494:
492:
490:
486:
479:
475:
474:
472:
470:
466:
459:
455:
454:
452:
450:
446:
439:
435:
434:
432:
430:
426:
419:
415:
414:
412:
405:
401:
394:
390:
389:
387:
385:
381:
371:
367:
366:
363:
356:
351:
347:
344:Fecal (85%),
343:
341:
337:
333:
331:
324:
321:
318:
316:
312:
308:
306:
302:
298:
294:
287:
285: Rx-only
278:
276:
266:
263:
253:
250:
240:
239:
237:
235:
231:
226:
218:
213:
210:
209:
207:
205:
201:
197:
193:
190:
188:
182:
176:
167:
166:
164:
162:
156:
149:
145:
135:
132:
127:
118:
115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
68:
64:
60:
56:
54:
50:
47:Clinical data
45:
41:
36:
32:
27:
19:
7856:Orphan drugs
7846:Chloroarenes
7642:Trifluthepin
7612:Perphenazine
7592:Oxyprothepin
7587:Oxyclothepin
7547:Fluphenazine
7512:Clopenthixol
7381:Tandospirone
7340:
7008:Vortioxetine
6983:Tolpiprazole
6933:Posaconazole
6863:Lorpiprazole
6853:Ketoconazole
6848:Itraconazole
6803:Elopiprazole
6793:Dropropizine
6743:Aripiprazole
6619:Cerebrolysin
6615:
6589:Pleiotrophin
6545:Interleukins
6458:
6439:
6409:
6328:Fruquintinib
6318:Cabozantinib
6299:
6289:
6247:
6211:Lestaurtinib
6162:
6142:
6110:Lestaurtinib
6061:
6051:
6032:Antagonists:
6031:
5965:Deoxygedunin
5920:3,7,8,2'-THF
5911:
5890:
5881:Against NGF:
5880:
5877:
5833:Against NGF:
5832:
5825:
5822:
5785:Lestaurtinib
5736:
5726:
5720:Testosterone
5702:Antagonists:
5701:
5651:
5564:
5551:
5536:
5511:
5492:
5482:
5461:
5451:
5430:
5420:
5399:
5384:
5344:
5259:
5227:
5206:
5197:Against NGF:
5196:
5193:
5149:Against NGF:
5148:
5145:
5139:Testosterone
5121:Antagonists:
5120:
5070:
5040:
5001:
4976:
4965:
4942:Teprotumumab
4903:
4873:
4832:
4781:Ficlatuzumab
4776:Emibetuzumab
4772:
4726:JNJ-38877605
4696:Cabozantinib
4667:
4657:
4646:Fosgonimeton
4641:
4616:
4558:
4536:
4477:
4460:Infigratinib
4456:
4441:
4344:
4261:
4195:Betacellulin
4191:
4174:Seribantumab
4160:
4137:
4096:
4061:
4055:Unknown/none
4054:
4050:
3984:
3909:
3868:Betacellulin
3863:Amphiregulin
3858:
3850:(ErbB1/HER1)
3814:
3786:
3766:
3752:Antagonists:
3751:
3736:
3729:Angiopoietin
3631:Pexidartinib
3616:Odronextamab
3586:Gilteritinib
3566:Cabozantinib
3513:
3479:
3454:
3448:Temsirolimus
3430:
3414:
3396:proapoptotic
3394:
3378:
3357:Zanubrutinib
3329:
3299:
3268:
3245:Lestaurtinib
3224:Janus kinase
3222:
3214:
3203:
3174:
3157:
3150:Non-receptor
3131:Cabozantinib
3124:
3093:Infigratinib
3078:
3052:
2994:Fruquintinib
2976:
2969:Gilteritinib
2965:Lestaurtinib
2958:
2907:
2876:
2849:Mobocertinib
2814:Aumolertinib
2802:
2767:Tremelimumab
2752:Tislelizumab
2707:Retifanlimab
2582:Blinatumomab
2552:Atezolizumab
2523:
2505:
2495:
2477:Obinutuzumab
2455:
2437:
2404:
2387:
2345:
2328:
2248:
2212:
2208:
2161:
2155:
2107:
2101:
2074:. Retrieved
2064:
2031:
2027:
1994:. Retrieved
1985:
1945:. Retrieved
1936:
1927:
1915:. Retrieved
1906:
1897:
1885:. Retrieved
1881:the original
1872:
1862:
1854:the original
1849:
1840:
1828:. Retrieved
1824:the original
1819:
1810:
1796:
1761:
1755:
1705:
1699:
1659:
1655:
1645:
1610:
1606:
1571:. Retrieved
1562:
1511:
1505:
1495:
1485:27 September
1483:. Retrieved
1479:the original
1474:
1465:
1438:
1434:
1424:
1394:(1): 85–96.
1391:
1387:
1381:
1372:10665/325771
1362:
1353:
1341:. Retrieved
1294:. Retrieved
1286:
1246:. Retrieved
1239:
1227:
1210:
1191:
1180:in cultured
1175:
1159:
1151:
1147:
1143:
1130:
1127:
1124:
1121:
1118:Legal status
1099:
1053:
1034:Pharmacology
1021:
1009:hypocalcemia
925:thrombocytes
921:erythrocytes
906:
887:
873:
858:
855:Medical uses
846:
791:
766:
762:
761:
750:
744:
369:
327:Elimination
234:Legal status
228:Legal status
95:License data
18:
7866:Piperazines
7738:Mirodenafil
7723:JNJ-7777120
7713:Hexocyclium
7678:Bucinnazine
7632:Thiothixene
7617:Pirenzepine
7602:Perathiepin
7542:Flupentixol
7532:Doclothepin
7527:Cyanothepin
7517:Clorotepine
7485:Ziprasidone
7475:Revospirone
7470:Perospirone
7457:piperazines
7434:Mirtazapine
7429:Delavirdine
7401:Zalospirone
7376:Revospirone
7288:Lidoflazine
7278:Hydroxyzine
7208:Clocinizine
7203:Cinnarizine
7136:Vesnarinone
7018:WAY-100,635
7013:WAY-100,135
6998:Vesnarinone
6918:Pardoprunox
6883:Mepiprazole
6838:Flibanserin
6823:Etoperidone
6813:Enpiprazole
6808:Eltoprazine
6798:EGIS-12,233
6773:Dapiprazole
6748:Batoprazine
6738:Antrafenine
6662:Piperazines
6579:Oncomodulin
6443:Aflibercept
6433:Ranibizumab
6428:Ramucirumab
6418:Bevacizumab
6410:Antibodies:
6368:Regorafenib
6308:Altiratinib
6221:ONO-5390556
6191:Entrectinib
6166:Altiratinib
6120:ONO-5390556
6090:Entrectinib
6065:Altiratinib
5851:Frunevetmab
5823:Antibodies:
5800:ONO-5390556
5765:Entrectinib
5740:Altiratinib
5695:Tavilermide
5590:Quizartinib
5529:SCF (c-Kit)
5353:Ramucirumab
5345:Antibodies:
5318:Quizartinib
5268:Avapritinib
5231:Becaplermin
5167:Frunevetmab
5146:Antibodies:
5049:Trofinetide
4980:Dusigitumab
4977:Antibodies:
4932:Robatumumab
4922:Figitumumab
4917:Dalotuzumab
4912:Cixutumumab
4904:Antibodies:
4796:Rilotumumab
4791:Onartuzumab
4786:Flanvotumab
4773:Antibodies:
4741:PF-04217903
4671:Altiratinib
4634:HGF (c-Met)
4537:Antibodies:
4442:Antibodies:
4164:Duligotumab
4161:Antibodies:
4075:Trastuzumab
4065:Ertumaxomab
4062:Antibodies:
4033:Zalutumumab
4028:Panitumumab
4023:Nimotuzumab
4018:Necitumumab
4008:Imgatuzumab
3985:Antibodies:
3968:Osimertinib
3933:Dacomitinib
3828:Dapiclermin
3787:Antibodies:
3770:Altiratinib
3661:Tebentafusp
3641:Regorafenib
3636:Quizartinib
3626:Pemigatinib
3606:Midostaurin
3581:Erdafitinib
3576:Entrectinib
3559:Parsaclisib
3507:Trilaciclib
3497:Palbociclib
3492:Dalpiciclib
3487:Abemaciclib
3389:Aflibercept
3316:Entrectinib
3286:Selumetinib
3281:Cobimetinib
3276:Binimetinib
3260:Ruxolitinib
3250:Momelotinib
3230:Baricitinib
3128:inhibitors:
3105:Pralsetinib
3101:Pemigatinib
3089:Futibatinib
3085:Entrectinib
3082:inhibitors:
3014:Regorafenib
2918:Avapritinib
2864:Rociletinib
2859:Osimertinib
2824:Dacomitinib
2762:Toripalimab
2747:Teclistamab
2737:Talquetamab
2732:Tafasitamab
2727:Sugemalimab
2722:Serplulimab
2712:Sabatolimab
2702:Ramucirumab
2697:Prolgolimab
2667:Necitumumab
2622:Epcoritamab
2602:Dostarlimab
2592:Daratumumab
2547:Amivantamab
2512:Alemtuzumab
2502:Brentuximab
2492:Tositumomab
2467:Ibritumomab
2448:Elranatamab
2411:Bevacizumab
2399:Edrecolomab
2394:Catumaxomab
2356:Trastuzumab
2340:Panitumumab
2245:"Dasatinib"
1757:Cancer Cell
1475:nelm.nhs.uk
1337:"Dasatinib"
1156:Brand names
993:pleurodesis
977:Neutropenia
671: g·mol
608:100.228.321
538:CHEBI:49375
393:302962-49-8
353:Identifiers
81:MedlinePlus
53:Trade names
7825:Categories
7773:Vardenafil
7763:Sildenafil
7753:Ranolazine
7693:Cinepazide
7577:Olanzapine
7567:Metitepine
7495:Tricyclics
7480:Tiospirone
7465:Lurasidone
7419:Atevirdine
7396:Umespirone
7391:Trimazosin
7356:Ipsapirone
7346:Eptapirone
7318:Vanoxerine
7293:Manidipine
7273:GBR-13,119
7268:GBR-13,098
7263:GBR-13,069
7258:GBR-12,935
7253:GBR-12,783
7233:Dotarizine
7188:Cetirizine
7173:BRL-15,572
7168:Amperozide
7111:Piberaline
7051:Bifeprunox
7046:Befuraline
7003:Vilazodone
6968:SB-399,885
6963:SB-357,134
6958:SB-271,046
6953:SB-258,585
6913:Oxypertine
6908:Niaprazine
6903:Nefazodone
6888:Naftopidil
6843:Fluprazine
6833:Fluanisone
6828:Flesinoxan
6758:BRL-15,572
6753:Bifeprunox
6733:Acaprazine
6700:Piperazine
6398:Vandetanib
6363:Rebastinib
6358:Pegaptanib
6348:Nintedanib
6338:Lenvatinib
6303:Agerafenib
6256:Ripretinib
6181:CH-7057288
6080:CH-7057288
5945:7,8,3'-THF
5940:7,8,2'-THF
5866:Ranevetmab
5856:Fulranumab
5810:Rebastinib
5755:CH-7057288
5670:Cenegermin
5555:Agerafenib
5515:Agerafenib
5496:Vandetanib
5465:Vandetanib
5434:Vandetanib
5403:Vandetanib
5348:Olaratumab
5323:Ripretinib
5303:Nintedanib
5288:Lenvatinib
5278:Crenolanib
5263:Agerafenib
5182:Ranevetmab
5172:Fulranumab
5089:Cenegermin
5063:LNGF (p75)
4985:Xentuzumab
4947:Xentuzumab
4892:NVP-AEW541
4887:NVP-ADW742
4882:Linsitinib
4877:BMS-754807
4862:Mecasermin
4761:Tivantinib
4751:PHA-665752
4746:PF-2341066
4716:Golvatinib
4706:Crizotinib
4701:Capmatinib
4691:BMS-777607
4686:Amuvatinib
4562:Ersofermin
4525:Sprifermin
4481:Ersofermin
4430:Sprifermin
4420:Repifermin
4415:Palifermin
4348:Ersofermin
4327:Velafermin
4312:Repifermin
4265:Ersofermin
4184:ErbB4/HER4
4169:Patritumab
4130:ErbB3/HER3
4110:Mubritinib
4070:Pertuzumab
4043:ErbB2/HER2
3973:Vandetanib
3928:Canertinib
3923:Brigatinib
3918:Agerafenib
3898:Nepidermin
3893:Murodermin
3883:Epiregulin
3838:EGF (ErbB)
3796:Nesvacumab
3790:Evinacumab
3780:Rebastinib
3721:modulators
3676:Venetoclax
3671:Vandetanib
3646:Ripretinib
3611:Nintedanib
3596:Lenvatinib
3571:Capmatinib
3554:Idelalisib
3544:Copanlisib
3517:inhibitors
3502:Ribociclib
3473:Vismodegib
3458:inhibitors
3438:Everolimus
3404:prohibitin
3321:Lorlatinib
3311:Crizotinib
3291:Trametinib
3255:Pacritinib
3240:Filgotinib
3235:Fedratinib
3139:Crizotinib
3135:Capmatinib
3117:Vandetanib
3065:Brigatinib
3044:Vandetanib
3004:Nintedanib
2999:Lenvatinib
2938:Ripretinib
2869:Vandetanib
2844:Lazertinib
2819:Brigatinib
2742:Tarlatamab
2677:Olaratumab
2637:Isatuximab
2632:Ipilimumab
2612:Elotuzumab
2607:Durvalumab
2587:Cemiplimab
2577:Bermekimab
2567:Axatilimab
2482:Ofatumumab
2462:Glofitamab
2444:Glofitamab
2352:Pertuzumab
1343:8 December
1219:References
1196:, whereas
1162:Bangladesh
1094:See also:
917:leukocytes
777:(CML) and
676:3D model (
664:Molar mass
558:ChEMBL1421
498:X78UG0A0RN
469:ChemSpider
429:IUPHAR/BPS
384:CAS Number
362:IUPAC name
315:Metabolism
7876:Thiazoles
7768:Tadalafil
7748:Quipazine
7728:Lodenafil
7718:Indinavir
7708:EGIS-7625
7683:Cinepazet
7673:Azimilide
7582:Opipramol
7522:Clozapine
7507:Amoxapine
7439:ORG-12962
7424:Azaperone
7386:Tirilazad
7366:Prazitone
7361:Piribedil
7341:Dasatinib
7336:Buspirone
7308:Oxatomide
7298:Meclozine
7213:Cyclizine
7178:Buclizine
7163:Almitrine
7126:Sunifiram
7116:Piribedil
7096:Meclozine
7056:Buclizine
6988:Trazodone
6893:Naluzotan
6818:Ensaculin
6695:Midafotel
6423:Icrucumab
6403:WHI-P 154
6393:Tivozanib
6388:Toceranib
6383:Sunitinib
6378:Sorafenib
6373:Semaxanib
6353:Pazopanib
6343:Motesanib
6333:Lapatinib
6323:Cediranib
6261:Telbermin
6248:Agonists:
6196:GZ-389988
6176:CE-245677
6143:Agonists:
6095:GZ-389988
6075:CE-245677
5975:Diosmetin
5912:Agonists:
5878:Aptamers:
5871:Tanezumab
5846:Fasinumab
5790:Milciclib
5770:GZ-389988
5750:CE-245677
5652:Agonists:
5605:Toceranib
5600:Sunitinib
5595:Sorafenib
5585:Pazopanib
5580:Nilotinib
5575:Masitinib
5565:Dasatinib
5537:Agonists:
5483:Agonists:
5452:Agonists:
5421:Agonists:
5393:Liatermin
5385:Agonists:
5368:RET (GFL)
5358:Tovetumab
5338:Toceranib
5333:Sorafenib
5328:Sunitinib
5313:Radotinib
5308:Pazopanib
5298:Motesanib
5293:Masitinib
5228:Agonists:
5194:Aptamers:
5187:Tanezumab
5162:Fasinumab
5071:Agonists:
4927:Ganitumab
4847:IGF-1 LR3
4766:Volitinib
4721:INCB28060
4711:Foretinib
4617:Agonists:
4601:Trafermin
4559:Agonists:
4540:Burosumab
4530:Trafermin
4478:Agonists:
4445:Aprutumab
4435:Trafermin
4397:10 (KGF2)
4345:Agonists:
4322:Trafermin
4302:10 (KGF2)
4262:Agonists:
4192:Agonists:
4138:Agonists:
4120:Tucatinib
4115:Neratinib
4105:Lapatinib
4013:Matuzumab
4003:Futuximab
3988:Cetuximab
3978:WHI-P 154
3963:Neratinib
3958:Lapatinib
3948:Grandinin
3943:Gefitinib
3938:Erlotinib
3815:Agonists:
3775:CE-245677
3737:Agonists:
3666:Tepotinib
3656:Sunitinib
3651:Sorafenib
3621:Pazopanib
3601:Masitinib
3549:Duvelisib
3539:Alpelisib
3527:Sotorasib
3522:Adagrasib
3468:Sonidegib
3463:Glasdegib
3409:Adipotide
3342:Ibrutinib
3215:Dasatinib
3210:Bosutinib
3195:Radotinib
3190:Ponatinib
3185:Nilotinib
3175:Dasatinib
3170:Bosutinib
3165:Asciminib
3133:(VEGFR),
3091:(FGFR2),
3070:Ceritinib
3060:Alectinib
3039:Toceranib
3034:Tivozanib
3029:Sunitinib
3024:Sorafenib
3019:Semaxanib
3009:Pazopanib
2989:Cediranib
2953:Toceranib
2948:Sunitinib
2943:Sorafenib
2933:Pazopanib
2928:Masitinib
2895:Tucatinib
2890:Neratinib
2885:Lapatinib
2854:Olmutinib
2834:Gefitinib
2829:Erlotinib
2804:HER1/EGFR
2672:Nivolumab
2662:Naxitamab
2487:Rituximab
2335:Cetuximab
2330:HER1/EGFR
2070:"Dasanix"
2056:206903723
2034:: g6593.
1887:29 August
1416:207489056
1198:quercetin
1140:Economics
1080:nilotinib
965:tiredness
957:skin rash
909:infection
826:pregnancy
763:Dasatinib
340:Excretion
329:half-life
185:Routes of
159:Pregnancy
148:Dasatinib
131:Dasatinib
73:Monograph
67:Drugs.com
23:Dasatinib
7836:Anilides
7815:Medicine
7788:Zipeprol
7783:WY-46824
7778:VUF-6002
7607:Perazine
7557:Loxapine
7351:Gepirone
7283:JJC8-088
7248:DPI-3290
7183:BW373U86
7081:Imatinib
7076:Fipexide
7036:2C-B-BZP
6993:Urapidil
6948:S-15,535
6943:S-14,671
6938:S-14,506
6768:CSP-2503
6605:instead)
6594:Renalase
6555:instead)
6526:instead)
6473:instead)
6313:Axitinib
6282:D (FIGF)
6226:PLX-7486
6216:ONO-4474
6171:AZD-6918
6125:PLX-7486
6115:ONO-4474
6070:AZD-6918
6052:Ligands:
5970:Deprenyl
5930:7,3'-DHF
5861:MEDI-578
5841:ASP-6294
5805:PLX-7486
5795:ONO-4474
5745:AZD-6918
5705:ALE-0540
5626:instead.
5570:Imatinib
5560:Axitinib
5540:Ancestim
5505:Unsorted
5283:Imatinib
5273:Axitinib
5177:MEDI-578
5157:ASP-6294
5124:ALE-0540
4966:Agonists
4907:AVE-1642
4833:Agonists
4756:SU-11274
4642:Agonists
4620:FGF15/19
4610:Unsorted
4575:2 (bFGF)
4494:2 (bFGF)
4361:2 (bFGF)
4278:2 (bFGF)
4100:Afatinib
4051:Agonists
3953:Icotinib
3913:Afatinib
3859:Agonists
3456:hedgehog
3418:against
3416:exotoxin
3382:against
3331:Bruton's
3180:Imatinib
3103:(FGFR),
3099:(NTRK),
2984:Axitinib
2923:Axitinib
2879:HER2/neu
2839:Icotinib
2809:Afatinib
2783:("-nib")
2562:Avelumab
2434:lymphoid
2426:lymphoma
2422:Leukemia
2347:HER2/neu
2309:("-mab")
2229:15615512
2188:31746100
2134:32686219
2048:25370846
1996:28 April
1947:28 April
1917:28 April
1830:23 April
1788:32289275
1734:32664269
1678:16740718
1637:29334406
1573:28 April
1538:29334406
1457:17591830
1408:28032244
1361:(2019).
1296:28 April
1172:Research
1076:imatinib
1044:PDB 2GQG
1019:damage.
1001:headache
945:vomiting
941:diarrhea
929:headache
840:and the
836:such as
810:swelling
796:include
787:by mouth
753:(verify)
449:DrugBank
204:ATC code
192:By mouth
161:category
126:DailyMed
7758:SA-4503
7243:DPI-287
7238:DPI-221
7218:DBL-583
7158:AD-1211
7121:RN-1747
7106:NSI-189
6728:3,4-CFP
6723:2C-B-PP
6482:Ephrins
6186:DS-6051
6085:DS-6051
5990:LM22A-4
5980:DMAQ-B1
5935:7,8-DHF
5915:3,7-DHF
5884:RBM-004
5829:GBR-900
5760:DS-6051
5730:VM-902A
5200:RBM-004
4897:OSl-906
4857:Insulin
4736:MK-2461
4681:AMG-458
3818:Axokine
3159:bcr-abl
2520:myeloid
2179:6895604
2125:7405395
2072:. Medex
1779:7722523
1725:7402330
1628:5903230
1529:5903230
1248:18 July
1090:History
1060:BCR/Abl
937:dyspnea
838:Bcr-Abl
792:Common
767:Sprycel
625:Formula
478:2323020
458:DB01254
418:3062316
404:PubChem
220:)
214: (
212:L01EA02
196:tablets
174: D
146::
128::
111::
87:a607063
7801:Portal
7733:MK-212
7668:AP-238
7313:SNC-80
6873:Mefway
6452:Others
6146:BNN-20
6035:ANA-12
5960:BNN-20
5680:DHEA-S
5665:BNN-27
5660:BNN-20
5099:DHEA-S
5084:BNN-27
5079:BNN-20
4995:Others
4200:Epigen
3878:Epigen
2406:VEGF-A
2227:
2186:
2176:
2132:
2122:
2076:19 May
2054:
2046:
1786:
1776:
1732:
1722:
1676:
1635:
1625:
1536:
1526:
1455:
1414:
1406:
1202:Bcl-xL
999:, and
949:nausea
923:, and
820:, and
806:anemia
702:SMILES
669:488.01
549:ChEMBL
518:D03658
346:kidney
275:℞-only
273:
260:
247:
141:
124:
114:by INN
107:
7743:PB-28
7698:CPD-1
7303:MT-45
7091:MDBZP
6978:TFMPP
6878:MeOPP
6705:PIPES
6690:HEPPS
6601:(see
6551:(see
6522:(see
6469:(see
6201:K252a
6100:K252a
5775:K252a
5715:FX007
5475:GFRα4
5444:GFRα3
5413:GFRα2
5377:GFRα1
5005:IGFBP
4958:IGF-2
4937:R1507
4825:IGF-1
4731:K252a
4551:FGFR4
4470:FGFR3
4337:FGFR2
4254:FGFR1
3400:ANXA2
3372:Other
3270:MAP2K
3141:(ALK)
3126:c-MET
2978:VEGFR
2913:PDGFR
2909:C-kit
2540:Other
2389:EpCAM
2052:S2CID
1990:(FDA)
1986:U.S.
1941:(FDA)
1937:U.S.
1911:(FDA)
1907:U.S.
1567:(FDA)
1563:U.S.
1412:S2CID
1388:Drugs
1290:(EMA)
1243:(TGA)
1236:(PDF)
1068:c-Kit
1046:) of
997:edema
973:fever
722:InChI
678:JSmol
529:ChEBI
320:Liver
7086:MBZP
7071:DBZP
6928:pFPP
6923:pCPP
6868:mCPP
6783:DMPP
6778:DCPP
6603:here
6553:here
6524:here
6471:here
6266:VEGF
6240:VEGF
6156:NT-3
6151:DHEA
6135:TrkC
6055:DHEA
6025:TDP6
6005:NT-4
6000:NT-3
5985:HIOC
5955:BDNF
5904:TrkB
5675:DHEA
5644:TrkA
5624:here
5622:See
5615:TGFβ
5220:PDGF
5114:NT-4
5109:NT-3
5094:DHEA
5074:BDNF
3823:CNTF
3807:CNTF
3515:KRAS
3420:IL-2
3402:and
3384:VEGF
3301:EML4
2960:FLT3
2911:and
2799:ErbB
2525:CD33
2507:CD52
2497:CD30
2457:CD20
2325:ErbB
2225:PMID
2184:PMID
2130:PMID
2078:2021
2044:PMID
1998:2020
1949:2020
1919:2020
1889:2016
1832:2015
1784:PMID
1730:PMID
1674:PMID
1633:PMID
1575:2020
1534:PMID
1487:2011
1453:PMID
1404:PMID
1345:2017
1298:2020
1250:2020
1078:and
979:and
509:KEGG
489:UNII
438:5678
348:(4%)
299:data
63:AHFS
7061:BZP
6020:R13
5690:NGF
5635:Trk
5104:NGF
4816:IGF
4676:AM7
4567:FGF
4486:FGF
4387:),
4385:KGF
4353:FGF
4270:FGF
4245:FGF
3847:EGF
3305:ALK
3205:Src
3080:RET
3054:ALK
2504:),
2494:),
2454:),
2439:CD3
2295:L01
2217:doi
2174:PMC
2166:doi
2120:PMC
2112:doi
2108:288
2036:doi
2032:349
2028:BMJ
1774:PMC
1766:doi
1720:PMC
1710:doi
1664:doi
1623:PMC
1615:doi
1524:PMC
1516:doi
1443:doi
1396:doi
1367:hdl
1160:In
1064:Src
991:or
927:),
574:EPA
408:CID
309:96%
262:POM
217:WHO
144:FDA
109:EMA
7827::
6514:B3
6512:,
6510:B2
6508:,
6506:B1
6504:,
6502:A5
6500:,
6498:A4
6496:,
6494:A3
6492:,
6490:A2
6488:,
6486:A1
6280:,
6276:,
6272:,
6015:R7
5831:;
5250:,
5246:,
5242:,
5031:,
5027:,
5023:,
5019:,
5015:,
5011:,
4968::
4835::
4644::
4595:19
4593:,
4589:,
4585:,
4581:,
4577:,
4573:,
4514:23
4512:,
4510:18
4508:,
4504:,
4500:,
4496:,
4492:,
4409:22
4407:,
4405:18
4403:,
4401:17
4399:,
4395:,
4391:,
4379:,
4375:,
4371:,
4367:,
4363:,
4359:,
4306:20
4304:,
4300:,
4296:,
4292:,
4288:,
4284:,
4280:,
4276:,
4228:,
4224:,
4220:,
4216:,
4151:,
4147:,
4053::
3861::
3137:,
3107:,
3095:,
2967:,
2906::
2801::
2522::
2450:,
2446:,
2436::
2354:,
2327::
2304:CI
2289:/
2247:.
2223:.
2213:47
2211:.
2182:.
2172:.
2162:11
2160:.
2154:.
2142:^
2128:.
2118:.
2106:.
2100:.
2086:^
2050:.
2042:.
2030:.
2016:^
1984:.
1967:^
1935:.
1905:.
1875:.
1871:.
1848:.
1818:.
1782:.
1772:.
1762:37
1760:.
1754:.
1742:^
1728:.
1718:.
1706:21
1704:.
1698:.
1686:^
1672:.
1660:66
1658:.
1654:.
1631:.
1621:.
1611:84
1609:.
1605:.
1593:^
1561:.
1546:^
1532:.
1522:.
1512:84
1510:.
1504:.
1473:.
1451:.
1439:18
1437:.
1433:.
1410:.
1402:.
1392:77
1390:.
1316:^
1285:.
1258:^
1238:.
1184:.
1070:,
1066:,
975:.
971:,
967:,
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911:,
871:.
851:.
844:.
816:,
808:,
804:,
800:,
789:.
642:Cl
639:26
633:22
281:EU
269:US
256:UK
249:S4
243:AU
170:AU
138:US
121:US
104:EU
7803::
6654:e
6647:t
6640:v
6547:/
6516:)
6484:(
6284:)
6278:C
6274:B
6270:A
6268:(
5817:)
5254:)
5252:D
5248:C
5244:B
5240:A
5238:(
5035:)
5033:7
5029:6
5025:5
5021:4
5017:3
5013:2
5009:1
5007:(
4597:)
4591:9
4587:8
4583:6
4579:4
4571:1
4569:(
4516:)
4506:9
4502:8
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4381:7
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4373:5
4369:4
4365:3
4357:1
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4308:)
4298:8
4294:6
4290:5
4286:4
4282:3
4274:1
4272:(
4232:)
4226:4
4222:3
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3407:(
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3217:)
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2963:(
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2528:(
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2500:(
2460:(
2442:(
2424:/
2413:)
2409:(
2401:)
2392:(
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2350:(
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2231:.
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2080:.
2058:.
2038::
2011:.
2000:.
1962:.
1951:.
1921:.
1891:.
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1790:.
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1736:.
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1680:.
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1347:.
1311:.
1300:.
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657:S
654:2
651:O
648:7
645:N
636:H
630:C
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572:(
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283::
271::
258::
245::
198:)
194:(
172::
65:/
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