337:
325:
2777:
2765:
424:
of
Quinvaxem, or cases for which the information available did not allow for a definite conclusion but there were no clinical signs that were consistent with the use of the vaccine. The WHO report emphasized that more than 400 million doses of Quinvaxem had been administered and that no fatal adverse event had ever been associated with Quinvaxem or similar vaccines.
435:
following immunization with pentavalent vaccines, the WHO asked a global panel of independent experts to review the safety of the vaccine. This review took place 12–13 June 2013 and concluded that no unusual reaction could be attributed to pentavalent vaccines. On 20 June 2013, the
Ministry of Health
423:
After a review of the cases conducted by national experts together with staff from WHO and UNICEF and an independent clinician, no link with vaccination could be identified. The fatalities reported in Viet Nam were attributed to coincidental health problems related in time but not related to the use
379:
introduced
Quinvaxem in January 2008. Within three months, four reports of deaths and 24 reports of suspected hypotonic-hyporesponsive episodes prompted regulatory attention and precautionary suspension of the initial vaccine lot. A subsequent death that occurred with the next lot in April 2009 led
407:
shortly after pentavalent vaccination prompted the authorities to suspend vaccination on 23 October 2009. Subsequently, four additional serious cases related to vaccine administered prior to suspension were identified and investigated. After a comprehensive review by independent national and
336:
439:
The reported events in these Asian nations caused public uncertainty regarding the use of pentavalent vaccines to spread to other developing nations. In response to this, and a corresponding spread of inaccurate information about vaccine safety, the
980:
837:
310:
High-income countries tend to use alternative formulations using acellular pertussis (Pa), which has a more favourable profile of side-effects, rather than whole-cell pertussis components. In Europe,
1603:
1151:
801:
324:
420:
of children who had recently received injections of the pentavalent vaccine
Quinvaxem. On 4 May 2013, the Ministry of Health of Viet Nam announced that use of Quinvaxem was suspended.
724:
274:
and other developing nations in separate documents about the use of pentavalent vaccines to protect against five of the leading causes of vaccine-preventable death in children.
1590:
356:
In 2013, it was found that
Pentavac PFS vaccines were being supplied with two different sets of packaging: One set with manufacturing and expiry dates was being provided to
1025:
240:
to young children who have been given a vaccination course with another pentavalent booster that requires a change in constitution and was also found to be adequately
1183:
845:
1251:
1461:
1316:
270:
In 2012, UNICEF and the World Health
Organization issued and recommended a joint statement to the Immunization Division, Ministry of Health and Family Welfare,
999:
100:
1611:
1055:
Obando-Pacheco P, Rivero-Calle I, GĂłmez-Rial J, RodrĂguez-Tenreiro Sánchez C, MartinĂłn-Torres F (August 2018). "New perspectives for hexavalent vaccines".
925:
1618:
2668:
812:
1816:
1283:
1705:
1856:
1851:
1577:
637:
735:
1401:
948:
2248:
388:
vaccination. Following an investigation by independent national and international experts, the vaccine was reintroduced in 2010.
2037:
1033:
1866:
1218:
2719:
2647:
300:
announced a US$ 110 million award from UNICEF to supply its pentavalent pediatric vaccine
Quinvaxem to the developing world.
2253:
1193:
1261:
2285:
2042:
1968:
1821:
1371:
1648:
1471:
1343:
2695:
2007:
1640:
1421:
452:
Common versions of pentavalent vaccines include
Quinvaxem, Pentavac PFS, Easyfive TT, ComBE Five, Shan5, and Pentabio.
1103:"Shaping markets to benefit global health - A 15-year history and lessons learned from the pentavalent vaccine market"
674:"Shaping markets to benefit global health - A 15-year history and lessons learned from the pentavalent vaccine market"
307:
announced that the cost of the pentavalent vaccine for emerging-market countries had dropped below US$ 3.00 per dose.
2107:
649:
639:
2736:
2674:
1649:
638:
World Health
Organization, World Health Organization Department of Immunization, Vaccines and Biologicals (2004).
2295:
2263:
2258:
2092:
281:-containing vaccines procured by UNICEF, which supplies vaccines to a large proportion of the world's children.
2353:
1963:
315:
2802:
2151:
1861:
586:'s list of pre-approved and prequalified vaccines in mid-2011. It was re-approved by WHO on 2 October 2013.
441:
263:
In
September 2006, the first pentavalent vaccine formulation received pre-qualification approval from the
2755:
2273:
1715:
1698:
2323:
1288:
1256:
1226:
1188:
933:
903:
841:
808:
762:"A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador"
583:
264:
253:
1293:
2278:
2243:
2238:
2233:
1492:"Safety monitoring of a new pentavalent vaccine in the expanded programme on immunisation in Ghana"
485:
2817:
2724:
2657:
2638:
2434:
2406:
2368:
2363:
2343:
1871:
1490:
Dodoo AN, Renner L, van Grootheest AC, Labadie J, Antwi-Agyei KO, Hayibor S, et al. (2007).
838:"Public statement on Quintanrix: Withdrawal of the marketing authorisation in the European Union"
85:
75:
2705:
2634:
1633:
867:
233:
194:
190:
1054:
2700:
2529:
1985:
1931:
1841:
511:
364:. It was later clarified that the undated vaccines were supplied by UNICEF and complied with
149:
141:
2827:
2822:
2583:
2524:
2315:
1958:
1836:
1787:
1754:
1688:
343:
8:
2807:
2506:
2472:
2358:
2181:
2124:
2119:
2070:
1901:
1769:
1741:
1693:
524:
404:
361:
311:
271:
165:
131:
58:
46:
2176:
1921:
360:, whereas the other set without manufacturing and expiry dates was being distributed to
2539:
2373:
2114:
2080:
2065:
1941:
1926:
1911:
1831:
1749:
1521:
1441:
1348:
1127:
1102:
1101:
Malhame M, Baker E, Gandhi G, Jones A, Kalpaxis P, Iqbal R, et al. (August 2019).
1080:
958:
698:
673:
672:
Malhame M, Baker E, Gandhi G, Jones A, Kalpaxis P, Iqbal R, et al. (August 2019).
566:
198:
1535:"Pentavalent DTP vaccine: need to be incorporated in the vaccination program of India"
22:
2797:
2662:
2629:
2462:
2303:
2193:
2087:
1948:
1773:
1736:
1626:
1556:
1513:
1508:
1491:
1426:
1406:
1284:"Global Advisory Committee on Vaccine Safety, report of meeting held 12-13 June 2013"
1132:
1072:
783:
703:
645:
221:
2608:
1525:
898:
778:
761:
2812:
2588:
2573:
2429:
2290:
2203:
1546:
1503:
1122:
1114:
1084:
1064:
773:
693:
685:
357:
114:
2129:
1068:
760:
Suárez E, Asturias EJ, Hilbert AK, Herzog C, Aeberhard U, Spyr C (February 2010).
573:
on April 20, 2006), which provides four out of the five vaccine elements in bulk.
256:
granted marketing approval to the pentavalent vaccine Quintanrix, manufactured by
2769:
2593:
2391:
2198:
2156:
2047:
2027:
1997:
1980:
1906:
1896:
1826:
1765:
1761:
1710:
949:"With GAVI support, pentavalent vaccine is available in the 73 poorest countries"
257:
1118:
689:
612:
399:
introduced Easyfive-TT in September 2009. The identification of five cases with
2781:
2730:
2457:
2348:
2308:
2188:
2014:
1953:
1462:"Pentavalent vaccine, Easyfive, removed from WHO list of prequalified vaccines"
1184:"Update on quality and safety of Quinvaxem (DTwP-HepB-Hib) pentavalent vaccine"
1156:
498:
400:
241:
1379:
2791:
2613:
2598:
2568:
2563:
2418:
2171:
2166:
2075:
1720:
1321:
953:
432:
285:
92:
1975:
2690:
2333:
2228:
2161:
2102:
1782:
1673:
1653:
1560:
1517:
1136:
1076:
787:
707:
365:
237:
109:
1152:"Pentavalent vaccine maker claims Unicef exemption on manufacturing dates"
2477:
2467:
2328:
2134:
2022:
1990:
1916:
1778:
1669:
1661:
1446:
385:
278:
229:
225:
212:, which supplies vaccines to a large proportion of the world's children.
205:
185:
34:
2603:
2578:
2268:
2218:
1604:"Health Organization, Gates Foundation Promote Greater Use of Vaccines"
984:
173:
2652:
2223:
2096:
1665:
1551:
1534:
1000:"Price of life-saving vaccine expected to drop significantly in 2011"
537:
376:
181:
1578:"Drugs companies to lower price of vaccines in developing countries"
260:. Quintanrix was voluntarily withdrawn by the manufacturer in 2008.
2494:
2487:
2482:
2452:
2208:
2144:
2139:
1442:"Crucell Announces Product Approval in Korea for Quinvaxem Vaccine"
570:
1317:"Infant deaths cast shadow on scale-up of pentavalent vaccine use"
416:
Between December 2012 and March 2013 nine deaths were reported in
2213:
1657:
472:
417:
297:
177:
169:
63:
51:
39:
1591:"Pentavalent vaccine gets clean chit, set for national scale-up"
1489:
330:
The number of manufacturers making certified pentavalent vaccine
2516:
2501:
1792:
396:
209:
380:
the authorities to suspend pentavalent vaccine use and resume
2511:
2396:
2002:
1936:
562:
428:
408:
international experts, the vaccine was reintroduced in 2011.
2776:
641:
Immunization in Practice: A Practical Guide for Health Staff
346:
almost vanished. Graph by GAVI; non-UNICEF prices not shown.
1811:
759:
381:
304:
288:-supported countries to introduce the five-in-one vaccine.
236:
vaccine was found to have positive safety when given as a
1466:
1252:"Safety of Quinvaxem (DTwP-HepB-Hib) pentavalent vaccine"
561:
The vaccine was developed and manufactured by Crucell in
444:
released a statement in support of pentavalent vaccines.
725:"Diphtheria Tetanus and Pertussis Vaccine Supply Update"
277:
By 2013, pentavalent vaccines accounted for 100% of the
204:
By 2013, pentavalent vaccines accounted for 100% of the
1100:
671:
436:
announced that Viet Nam would resume use of Quinvaxem.
2753:
1219:"Frequently Asked Questions (FAQs) Quinvaxem vaccine"
431:, Sri Lanka, and Bhutan of a small number of serious
613:"5-in-1 Vaccine (also called Pentavalent Vaccine)"
2669:Cedillo v. Secretary of Health and Human Services
1532:
981:"Crucell Announces New Award of $ 110 Million..."
802:"Quintanrix : EPAR - Summary for the public"
2789:
303:In November 2010, the public-private consortium
1422:"Crucell's Quinvaxem gets WHO prequalification"
284:In 2014, South Sudan became the last of the 73
148:
140:
1634:
314:that also contain inactivated polio vaccine (
201:, where polio vaccine is given separately.
1641:
1627:
1344:"Pentavalent vaccine is safe, assures IAP"
1096:
1094:
1550:
1533:Verma R, Khanna P, Chawla S (July 2013).
1507:
1352:. Express News Service. 13 September 2013
1246:
1244:
1213:
1211:
1178:
1176:
1174:
1126:
777:
697:
644:. World Health Organization. p. 20.
172:conjugated into one. It protects against
719:
717:
342:All pentavalent vaccine prices fell and
1539:Human Vaccines & Immunotherapeutics
1091:
2790:
1276:
1241:
1208:
1171:
665:
631:
291:
1622:
1601:
1575:
1314:
1149:
893:
891:
889:
766:Revista Panamericana de Salud PĂşblica
714:
607:
605:
603:
80:Quintavax, Pentavac, Pentacel, others
1588:
113:
1454:
1336:
13:
2696:Eradication of infectious diseases
2453:Androvax (androstenedione albumin)
1482:
886:
600:
427:Following additional reports from
14:
2839:
2286:Respiratory syncytial virus (RSV)
1569:
208:-containing vaccines procured by
2775:
2763:
2675:Alternative vaccination schedule
1650:Artificial induction of immunity
1509:10.2165/00002018-200730040-00007
844:. 29 August 2008. Archived from
335:
323:
199:middle- and low-income countries
1434:
1414:
1394:
1364:
1308:
1143:
1048:
1018:
992:
973:
941:
918:
779:10.1590/S1020-49892010000200005
576:
555:
447:
2507:Ovandrotone albumin (Fecundin)
1402:"'Shan5' vaccine gets WHO nod"
1315:Datta PT (22 September 2013).
1292:. 19 July 2013. Archived from
860:
830:
794:
753:
734:. October 2016. Archived from
582:Easyfive was removed from the
220:During studies and tests, the
1:
2043:Group B streptococcal disease
1862:Vaccines for Children Program
1260:. 10 May 2013. Archived from
1192:. 5 July 2013. Archived from
1069:10.1016/j.vaccine.2017.06.063
593:
197:, which is generally used in
1150:Rajiv G (13 December 2013).
442:Indian Academy of Pediatrics
371:
7:
1119:10.1016/j.jvacx.2019.100033
899:"WHO Prequalified Vaccines"
690:10.1016/j.jvacx.2019.100033
10:
2844:
1589:Dhar A (11 October 2013).
464:Date pre-qualified by WHO
411:
247:
2714:
2683:
2622:
2554:
2445:
2417:
2384:
2058:
1889:
1882:
1801:
1729:
1681:
1289:World Health Organization
1257:World Health Organization
1227:World Health Organization
1189:World Health Organization
1030:World Health Organization
934:World Health Organization
904:World Health Organization
872:European Medicines Agency
842:European Medicines Agency
809:European Medicines Agency
617:Vaccine Knowledge Project
571:Novartis International AG
533:
520:
507:
494:
481:
468:
463:
460:
457:
391:
265:World Health Organization
254:European Medicines Agency
215:
130:
125:
99:
84:
74:
69:
57:
45:
33:
28:
2038:Clostridioides difficile
1602:Sinha V (10 June 2011).
548:
486:Serum Institute of India
351:
2296:Tick-borne encephalitis
1576:Quinn B (6 June 2011).
1322:The Hindu Business Line
2706:List of vaccine topics
1706:Mathematical modelling
191:Haemophilus influenzae
2701:Vaccinate Your Family
2152:Japanese encephalitis
926:"Pentavalent Vaccine"
512:Biological E. Limited
252:In October 2004, the
168:with five individual
162:DTwP-HepB-Hib vaccine
23:DTwP-HepB-Hib vaccine
2803:Combination vaccines
2584:John Franklin Enders
569:(later purchased by
362:government hospitals
344:price discrimination
1770:Virus-like particle
1694:Vaccine ingredients
1296:on 22 December 2013
1264:on 11 November 2013
1036:on 11 February 2015
874:. 25 September 2018
565:and co-produced by
525:Shantha Biotechnics
405:meningoencephalitis
318:) are in wide use.
312:hexavalent vaccines
292:Society and culture
272:Government of India
166:combination vaccine
59:Haemophilus vaccine
47:Hepatitis B vaccine
25:
16:Combination vaccine
2741:Never to phase III
2540:Hexavalent vaccine
2354:Epstein–Barr virus
2249:Oxford–AstraZeneca
1942:NmVac4-A/C/Y/W-135
1474:on 12 August 2013.
1349:The Indian Express
1006:. 26 November 2010
567:Chiron Corporation
477:26 September 2006
21:
2751:
2750:
2663:Vaccines and SIDS
2550:
2549:
2324:Hepatitis A and B
2300:Varicella zoster
1762:Subunit/component
1427:The Pharma Letter
1407:Business Standard
1196:on 30 August 2014
1063:(36): 5485–5494.
868:"Quintanrix EPAR"
546:
545:
542:19 December 2014
516:1 September 2011
358:private hospitals
159:
158:
2835:
2780:
2779:
2768:
2767:
2766:
2759:
2642:MMR autism fraud
2589:Maurice Hilleman
2574:Hilary Koprowski
1887:
1886:
1643:
1636:
1629:
1620:
1619:
1615:
1614:on 5 March 2016.
1610:. Archived from
1608:Voice of America
1598:
1585:
1564:
1554:
1552:10.4161/hv.24382
1529:
1511:
1476:
1475:
1470:. Archived from
1458:
1452:
1451:
1438:
1432:
1431:
1418:
1412:
1411:
1398:
1392:
1391:
1389:
1387:
1378:. Archived from
1368:
1362:
1361:
1359:
1357:
1340:
1334:
1333:
1331:
1329:
1312:
1306:
1305:
1303:
1301:
1280:
1274:
1273:
1271:
1269:
1248:
1239:
1238:
1236:
1234:
1223:
1215:
1206:
1205:
1203:
1201:
1180:
1169:
1168:
1166:
1164:
1147:
1141:
1140:
1130:
1098:
1089:
1088:
1052:
1046:
1045:
1043:
1041:
1032:. Archived from
1026:"Vaccine Market"
1022:
1016:
1015:
1013:
1011:
996:
990:
989:
988:(Press release).
977:
971:
970:
968:
966:
957:. Archived from
945:
939:
938:
930:
922:
916:
915:
913:
911:
895:
884:
883:
881:
879:
864:
858:
857:
855:
853:
834:
828:
827:
825:
823:
817:
811:. Archived from
806:
798:
792:
791:
781:
757:
751:
750:
748:
746:
740:
729:
721:
712:
711:
701:
669:
663:
662:
660:
658:
635:
629:
628:
626:
624:
609:
587:
580:
574:
559:
455:
454:
339:
327:
152:
144:
139:Quintavax:
117:
108:Quintavax:
26:
24:
20:
2843:
2842:
2838:
2837:
2836:
2834:
2833:
2832:
2788:
2787:
2786:
2774:
2764:
2762:
2754:
2752:
2747:
2746:
2731:Clinical trials
2710:
2679:
2618:
2594:Stanley Plotkin
2556:
2546:
2458:Cancer vaccines
2441:
2435:Schistosomiasis
2413:
2407:Trypanosomiasis
2380:
2344:Cytomegalovirus
2254:Pfizer–BioNTech
2054:
1878:
1827:Vaccine wastage
1797:
1725:
1677:
1647:
1572:
1567:
1485:
1483:Further reading
1480:
1479:
1460:
1459:
1455:
1440:
1439:
1435:
1420:
1419:
1415:
1400:
1399:
1395:
1385:
1383:
1382:on 6 April 2016
1370:
1369:
1365:
1355:
1353:
1342:
1341:
1337:
1327:
1325:
1313:
1309:
1299:
1297:
1282:
1281:
1277:
1267:
1265:
1250:
1249:
1242:
1232:
1230:
1221:
1217:
1216:
1209:
1199:
1197:
1182:
1181:
1172:
1162:
1160:
1148:
1144:
1099:
1092:
1053:
1049:
1039:
1037:
1024:
1023:
1019:
1009:
1007:
998:
997:
993:
979:
978:
974:
964:
962:
961:on 18 July 2014
947:
946:
942:
928:
924:
923:
919:
909:
907:
897:
896:
887:
877:
875:
866:
865:
861:
851:
849:
848:on 15 July 2018
836:
835:
831:
821:
819:
818:on 15 July 2018
815:
804:
800:
799:
795:
758:
754:
744:
742:
741:on 29 June 2018
738:
727:
723:
722:
715:
670:
666:
656:
654:
652:
636:
632:
622:
620:
619:. 22 March 2018
611:
610:
601:
596:
591:
590:
581:
577:
560:
556:
551:
503:2 October 2013
450:
414:
394:
374:
354:
347:
340:
331:
328:
294:
258:GlaxoSmithKline
250:
218:
155:
147:Pentavac:
121:
87:
17:
12:
11:
5:
2841:
2831:
2830:
2825:
2820:
2818:Whooping cough
2815:
2810:
2805:
2800:
2785:
2784:
2772:
2749:
2748:
2745:
2744:
2743:
2742:
2739:
2728:
2722:
2716:
2715:
2712:
2711:
2709:
2708:
2703:
2698:
2693:
2687:
2685:
2681:
2680:
2678:
2677:
2672:
2665:
2660:
2655:
2650:
2645:
2632:
2626:
2624:
2620:
2619:
2617:
2616:
2611:
2609:Katalin KarikĂł
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2571:
2566:
2560:
2558:
2552:
2551:
2548:
2547:
2545:
2544:
2543:
2542:
2537:
2532:
2527:
2519:
2514:
2509:
2504:
2499:
2498:
2497:
2492:
2491:
2490:
2485:
2475:
2470:
2465:
2455:
2449:
2447:
2443:
2442:
2440:
2439:
2438:
2437:
2432:
2423:
2421:
2415:
2414:
2412:
2411:
2410:
2409:
2401:
2400:
2399:
2388:
2386:
2382:
2381:
2379:
2378:
2377:
2376:
2371:
2366:
2364:Herpes simplex
2361:
2356:
2351:
2346:
2338:
2337:
2336:
2331:
2326:
2318:
2313:
2312:
2311:
2306:
2298:
2293:
2288:
2283:
2282:
2281:
2276:
2271:
2266:
2264:Sinopharm BIBP
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2214:Bharat Biotech
2211:
2201:
2196:
2191:
2186:
2185:
2184:
2179:
2169:
2164:
2159:
2154:
2149:
2148:
2147:
2142:
2132:
2127:
2122:
2117:
2112:
2111:
2110:
2105:
2100:
2085:
2084:
2083:
2073:
2068:
2062:
2060:
2056:
2055:
2053:
2052:
2051:
2050:
2045:
2040:
2032:
2031:
2030:
2025:
2017:
2012:
2011:
2010:
2005:
1995:
1994:
1993:
1983:
1978:
1973:
1972:
1971:
1966:
1956:
1951:
1946:
1945:
1944:
1939:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1893:
1891:
1884:
1880:
1879:
1877:
1876:
1875:
1874:
1869:
1864:
1859:
1854:
1846:
1845:
1844:
1842:Vaccine injury
1839:
1834:
1829:
1824:
1819:
1814:
1805:
1803:
1802:Administration
1799:
1798:
1796:
1795:
1790:
1785:
1776:
1759:
1758:
1757:
1752:
1744:
1739:
1733:
1731:
1727:
1726:
1724:
1723:
1718:
1713:
1708:
1703:
1702:
1701:
1691:
1685:
1683:
1679:
1678:
1646:
1645:
1638:
1631:
1623:
1617:
1616:
1599:
1586:
1571:
1570:External links
1568:
1566:
1565:
1530:
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1453:
1433:
1413:
1393:
1363:
1335:
1307:
1275:
1240:
1207:
1170:
1157:Times Of India
1142:
1090:
1047:
1017:
991:
972:
940:
917:
885:
859:
829:
793:
752:
713:
664:
650:
630:
598:
597:
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592:
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575:
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547:
544:
543:
540:
535:
531:
530:
529:29 April 2014
527:
522:
518:
517:
514:
509:
505:
504:
501:
499:Panacea Biotec
496:
492:
491:
488:
483:
479:
478:
475:
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466:
465:
462:
459:
449:
446:
433:adverse events
413:
410:
401:encephalopathy
393:
390:
373:
370:
353:
350:
349:
348:
341:
334:
332:
329:
322:
293:
290:
249:
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217:
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182:whooping cough
157:
156:
154:
153:
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136:
134:
128:
127:
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120:
119:
105:
103:
97:
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90:
88:administration
82:
81:
78:
72:
71:
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61:
55:
54:
49:
43:
42:
37:
31:
30:
29:Combination of
15:
9:
6:
4:
3:
2:
2840:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
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2806:
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2801:
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2740:
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2649:
2646:
2643:
2641:
2636:
2633:
2631:
2628:
2627:
2625:
2621:
2615:
2614:Drew Weissman
2612:
2610:
2607:
2605:
2602:
2600:
2599:H. Fred Clark
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2569:Louis Pasteur
2567:
2565:
2564:Edward Jenner
2562:
2561:
2559:
2553:
2541:
2538:
2536:
2535:DTwP-HepB-Hib
2533:
2531:
2530:DTaP-IPV-HepB
2528:
2526:
2523:
2522:
2521:combination:
2520:
2518:
2515:
2513:
2510:
2508:
2505:
2503:
2500:
2496:
2493:
2489:
2486:
2484:
2481:
2480:
2479:
2476:
2474:
2471:
2469:
2466:
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2461:
2460:
2459:
2456:
2454:
2451:
2450:
2448:
2444:
2436:
2433:
2431:
2428:
2427:
2425:
2424:
2422:
2420:
2419:Helminthiasis
2416:
2408:
2405:
2404:
2402:
2398:
2395:
2394:
2393:
2390:
2389:
2387:
2383:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2341:
2339:
2335:
2332:
2330:
2327:
2325:
2322:
2321:
2320:combination:
2319:
2317:
2314:
2310:
2307:
2305:
2302:
2301:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2206:
2205:
2202:
2200:
2197:
2195:
2192:
2190:
2187:
2183:
2180:
2178:
2175:
2174:
2173:
2170:
2168:
2165:
2163:
2160:
2158:
2155:
2153:
2150:
2146:
2143:
2141:
2138:
2137:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2109:
2106:
2104:
2101:
2098:
2094:
2091:
2090:
2089:
2086:
2082:
2079:
2078:
2077:
2074:
2072:
2069:
2067:
2064:
2063:
2061:
2057:
2049:
2046:
2044:
2041:
2039:
2036:
2035:
2033:
2029:
2026:
2024:
2023:DPT/DTwP/DTaP
2021:
2020:
2019:combination:
2018:
2016:
2013:
2009:
2006:
2004:
2001:
2000:
1999:
1996:
1992:
1989:
1988:
1987:
1984:
1982:
1979:
1977:
1974:
1970:
1967:
1965:
1962:
1961:
1960:
1957:
1955:
1952:
1950:
1947:
1943:
1940:
1938:
1935:
1934:
1933:
1932:Meningococcus
1930:
1928:
1925:
1923:
1922:Leptospirosis
1920:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1900:
1898:
1895:
1894:
1892:
1888:
1885:
1881:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1857:Vaccine court
1855:
1853:
1850:
1849:
1847:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1812:GAVI Alliance
1810:
1809:
1807:
1806:
1804:
1800:
1794:
1791:
1789:
1786:
1784:
1780:
1777:
1775:
1771:
1767:
1763:
1760:
1756:
1753:
1751:
1748:
1747:
1745:
1743:
1740:
1738:
1735:
1734:
1732:
1728:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1700:
1697:
1696:
1695:
1692:
1690:
1687:
1686:
1684:
1680:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1644:
1639:
1637:
1632:
1630:
1625:
1624:
1621:
1613:
1609:
1605:
1600:
1596:
1592:
1587:
1583:
1579:
1574:
1573:
1562:
1558:
1553:
1548:
1545:(7): 1497–9.
1544:
1540:
1536:
1531:
1527:
1523:
1519:
1515:
1510:
1505:
1502:(4): 347–56.
1501:
1497:
1493:
1488:
1487:
1473:
1469:
1468:
1463:
1457:
1449:
1448:
1443:
1437:
1429:
1428:
1423:
1417:
1410:. 5 May 2014.
1409:
1408:
1403:
1397:
1381:
1377:
1376:Vaccine World
1373:
1367:
1351:
1350:
1345:
1339:
1324:
1323:
1318:
1311:
1295:
1291:
1290:
1285:
1279:
1263:
1259:
1258:
1253:
1247:
1245:
1229:
1228:
1220:
1214:
1212:
1195:
1191:
1190:
1185:
1179:
1177:
1175:
1159:
1158:
1153:
1146:
1138:
1134:
1129:
1124:
1120:
1116:
1112:
1108:
1104:
1097:
1095:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1058:
1051:
1035:
1031:
1027:
1021:
1005:
1001:
995:
987:
986:
982:
976:
960:
956:
955:
954:GAVI Alliance
950:
944:
936:
935:
927:
921:
906:
905:
900:
894:
892:
890:
873:
869:
863:
847:
843:
839:
833:
814:
810:
803:
797:
789:
785:
780:
775:
772:(2): 117–24.
771:
767:
763:
756:
737:
733:
726:
720:
718:
709:
705:
700:
695:
691:
687:
683:
679:
675:
668:
653:
651:9789241546515
647:
643:
642:
634:
618:
614:
608:
606:
604:
599:
585:
579:
572:
568:
564:
558:
554:
541:
539:
536:
532:
528:
526:
523:
519:
515:
513:
510:
506:
502:
500:
497:
493:
490:23 June 2010
489:
487:
484:
482:Pentavac PFS
480:
476:
474:
471:
467:
461:Manufacturer
456:
453:
445:
443:
437:
434:
430:
425:
421:
419:
409:
406:
402:
398:
389:
387:
383:
378:
369:
367:
363:
359:
345:
338:
333:
326:
321:
320:
319:
317:
313:
308:
306:
301:
299:
296:In May 2010,
289:
287:
282:
280:
275:
273:
268:
266:
261:
259:
255:
245:
243:
239:
235:
231:
227:
223:
213:
211:
207:
202:
200:
196:
193:
192:
187:
183:
179:
175:
171:
167:
163:
151:
146:
143:
138:
137:
135:
133:
129:
124:
116:
111:
107:
106:
104:
102:
98:
94:
93:Intramuscular
91:
89:
83:
79:
77:
73:
70:Clinical data
68:
65:
62:
60:
56:
53:
50:
48:
44:
41:
38:
36:
32:
27:
19:
2691:Epidemiology
2667:
2639:
2534:
2525:DTaP-IPV/Hib
2316:Yellow fever
2229:EpiVacCorona
1986:Tuberculosis
1959:Pneumococcal
1927:Lyme disease
1755:Heterologous
1654:Immunization
1612:the original
1607:
1594:
1582:The Guardian
1581:
1542:
1538:
1499:
1495:
1472:the original
1465:
1456:
1445:
1436:
1425:
1416:
1405:
1396:
1386:17 September
1384:. Retrieved
1380:the original
1375:
1366:
1354:. Retrieved
1347:
1338:
1326:. Retrieved
1320:
1310:
1298:. Retrieved
1294:the original
1287:
1278:
1266:. Retrieved
1262:the original
1255:
1231:. Retrieved
1225:
1198:. Retrieved
1194:the original
1187:
1161:. Retrieved
1155:
1145:
1110:
1106:
1060:
1056:
1050:
1038:. Retrieved
1034:the original
1029:
1020:
1008:. Retrieved
1003:
994:
983:
975:
963:. Retrieved
959:the original
952:
943:
932:
920:
908:. Retrieved
902:
876:. Retrieved
871:
862:
850:. Retrieved
846:the original
832:
820:. Retrieved
813:the original
796:
769:
765:
755:
743:. Retrieved
736:the original
731:
681:
677:
667:
655:. Retrieved
640:
633:
621:. Retrieved
616:
578:
557:
495:Easyfive TT
451:
448:Formulations
438:
426:
422:
415:
395:
375:
355:
309:
302:
298:Crucell N.V.
295:
283:
276:
269:
262:
251:
219:
203:
189:
164:is a 5-in-1
161:
160:
150:1688606-53-2
142:1196465-46-9
18:
2828:Hepatitis B
2823:Haemophilus
2727:from market
2623:Controversy
2557:researchers
2473:Hepatitis B
2359:Hepatitis C
2304:Chicken pox
2130:Hepatitis E
2125:Hepatitis B
2120:Hepatitis A
2071:Chikungunya
2048:Shigellosis
1902:Brucellosis
1788:Therapeutic
1742:Inactivated
1682:Development
1670:Inoculation
1662:Vaccination
1496:Drug Safety
1447:Marketwired
508:ComBE Five
386:hepatitis B
242:immunogenic
186:hepatitis B
126:Identifiers
76:Trade names
35:DTP vaccine
2808:Diphtheria
2792:Categories
2658:Thiomersal
2604:Paul Offit
2579:Jonas Salk
2555:Inventors/
2426:research:
2403:research:
2340:research:
2269:Skycovione
2259:Sanofi–GSK
2204:SARS-CoV-2
2115:Hantavirus
2081:rVSV-ZEBOV
2066:Adenovirus
2034:research:
1912:Diphtheria
1750:Attenuated
1372:"Products"
1113:: 100033.
985:PRNewswire
965:7 December
878:13 October
684:: 100033.
594:References
469:Quinvaxem
366:Indian Law
222:conjugated
174:diphtheria
132:CAS Number
2737:Phase III
2725:Withdrawn
2653:Pox party
2463:ALVAC-CEA
2385:Protozoan
2274:Sputnik V
2224:CoronaVac
2194:Rotavirus
2097:Pandemrix
1949:Pertussis
1890:Bacterial
1774:Synthetic
1737:Conjugate
1689:Adjuvants
1666:Infection
1595:The Hindu
538:Bio Farma
534:Pentabio
377:Sri Lanka
372:Sri Lanka
95:injection
86:Routes of
2798:Vaccines
2770:Medicine
2495:Prostvac
2488:Gardasil
2483:Cervarix
2430:Hookworm
2309:Shingles
2291:Smallpox
2209:Corbevax
2145:Gardasil
2140:Cervarix
1883:Vaccines
1837:Schedule
1808:Global:
1716:Timeline
1658:Vaccines
1561:23571225
1526:37633844
1518:17408311
1137:31384748
1077:28676382
788:20339615
708:31384748
458:Vaccine
418:Viet Nam
170:vaccines
101:ATC code
2813:Tetanus
2782:Viruses
2756:Portals
2684:Related
2630:General
2392:Malaria
2279:Valneva
2244:Novavax
2239:Moderna
2234:Janssen
2219:CanSino
2199:Rubella
2157:Measles
2028:Td/Tdap
1998:Typhoid
1981:Tetanus
1976:Q fever
1907:Cholera
1897:Anthrax
1766:Peptide
1730:Classes
1711:Storage
1268:30 June
1233:30 June
1128:6668221
1107:Vaccine
1085:4384043
1057:Vaccine
1040:28 June
910:29 June
852:15 July
822:15 July
745:28 June
699:6668221
678:Vaccine
657:15 July
473:Crucell
412:Vietnam
403:and/or
248:History
238:booster
224:liquid
178:tetanus
118:)
112: (
110:J07CA11
64:Vaccine
52:Vaccine
40:Vaccine
2720:WHO-EM
2640:Lancet
2517:TA-NIC
2502:NicVAX
2349:Dengue
2189:Rabies
2015:Typhus
1954:Plague
1832:Policy
1793:Toxoid
1721:Trials
1559:
1524:
1516:
1356:3 July
1328:3 July
1300:3 July
1200:3 July
1163:3 July
1135:
1125:
1083:
1075:
1010:3 July
786:
732:UNICEF
706:
696:
648:
623:3 July
521:Shan5
397:Bhutan
392:Bhutan
216:Safety
210:UNICEF
195:type B
2648:NCVIA
2512:TA-CD
2446:Other
2397:RTS,S
2177:Sabin
2172:Polio
2167:Mumps
2076:Ebola
2059:Viral
2008:ViCPS
2003:Ty21a
1937:MeNZB
1867:VAERS
1817:NITAG
1746:Live
1522:S2CID
1222:(PDF)
1081:S2CID
929:(PDF)
816:(PDF)
805:(PDF)
739:(PDF)
728:(PDF)
563:Korea
549:Notes
429:India
352:India
2374:Zika
2334:MMRV
2182:Salk
2162:Mpox
2108:LAIV
2103:H5N1
2093:H1N1
1969:PPSV
1852:ACIP
1848:US:
1822:SAGE
1783:mRNA
1699:list
1557:PMID
1514:PMID
1388:2014
1358:2018
1330:2018
1302:2018
1270:2018
1235:2018
1202:2018
1165:2018
1133:PMID
1073:PMID
1042:2018
1012:2018
1004:GAVI
967:2015
912:2018
880:2023
854:2018
824:2018
784:PMID
747:2018
704:PMID
659:2018
646:ISBN
625:2018
384:and
382:DTwP
305:GAVI
286:GAVI
230:HepB
226:DTPw
188:and
2635:MMR
2478:HPV
2468:BCG
2369:HIV
2329:MMR
2135:HPV
2088:Flu
1991:BCG
1964:PCV
1917:Hib
1872:VSD
1779:DNA
1674:J07
1547:doi
1504:doi
1467:WHO
1123:PMC
1115:doi
1065:doi
774:doi
694:PMC
686:doi
584:WHO
316:IPV
279:DTP
234:Hib
206:DTP
115:WHO
2794::
2733::
1781:/
1772:/
1768:/
1764:/
1668:,
1664:,
1660:,
1656::
1652:/
1606:.
1593:.
1580:.
1555:.
1541:.
1537:.
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